CN109452987B

CN109452987B - Be used for mouse trachea cannula experimental apparatus

Info

Publication number: CN109452987B
Application number: CN201910005441.3A
Authority: CN
Inventors: 黄晓忠; 牛超; 陈潇依; 孙佳; 黄慧雅; 郭世坤
Original assignee: Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University
Current assignee: Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University
Priority date: 2019-01-03
Filing date: 2019-01-03
Publication date: 2020-09-01
Anticipated expiration: 2039-01-03
Also published as: CN109452987A

Abstract

The invention discloses an experimental device for tracheal intubation of a mouse, which comprises a base plate, a mounting plate and a bearing plate, wherein one end of the mounting plate is connected to the base plate, the other end of the mounting plate extends back to the base plate, the bearing plate is rotatably arranged on the mounting plate, the bearing plate is inclined relative to a horizontal plane, a suspension rope is arranged on the bearing plate, when the mouse lies on the bearing plate in a supine position, the suspension rope suspends the upper teeth of the mouse so as to fix the mouse, an illuminating mechanism for illuminating the inside of the oral cavity of the mouse is arranged on the mounting plate and comprises a slide rail and a lamp cylinder, the slide rail is arranged in parallel with the bearing plate, a slide groove is arranged on one side of the slide rail facing the bearing plate, a slide block is arranged on one end of the lamp cylinder, the slide block is connected with the slide groove in a sliding manner, a lamp holder for clinging to the skin, and the mounting plate is also provided with a rotating mechanism for simultaneously adjusting the inclination of the sliding rail and the inclination of the bearing plate.

Description

Be used for mouse trachea cannula experimental apparatus

Technical Field

The invention relates to the field of medical biological experimental equipment, in particular to an experimental device for mouse trachea cannula.

Background

The mice are experimental animals which are used more at present, and various methods such as tracheotomy, blind insertion, endoscope-assisted intubation and the like are used for performing the tracheal intubation experiment by using the mice at present, wherein the frequency of using the intubation under direct vision is high, and the method has the advantages of high success rate, no wound and the like. The operator uses a high-power incandescent bulb or a cold light source to cling to the skin of the neck of the mouse, and the trachea can be exposed by means of the light penetrating through the neck and the tongue root of the mouse by traction, so that the success rate of the direct-view intubation method is improved.

However, the intubate often needs the cooperation of two people to accomplish the experiment under the direct-view, place on experimental apparatus after the mouse anesthesia, the outside tractive of mouse tongue is held between the fingers to first person's one hand, in order to expose the oral cavity, mouse neck skin is hugged closely with high-power incandescent bulb or cold light source to another hand, and reciprocate at mouse neck skin, adjust the light that sees through the neck, until seeing clearly the inside tracheal position in oral cavity, at this moment, the second person inserts the trachea with the intubate through the oral cavity, this kind of intubate method is time-consuming, and manpower resources have greatly been wasted.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide the experimental device for the mouse trachea cannula, which can finish the experiment only by pinching the tongue of the mouse by one hand and pulling the tongue outwards, and then finishing the light source adjustment and the cannula insertion by the other hand in sequence.

In order to achieve the purpose, the invention provides the following technical scheme: a trachea cannula experiment device for mice comprises a base plate, a mounting plate and a bearing plate, wherein one end of the mounting plate is connected to the base plate, the other end of the mounting plate extends back to the base plate, the bearing plate is rotatably arranged on the mounting plate, the bearing plate inclines relative to a horizontal plane, a suspension rope is arranged on the bearing plate, when a mouse lies on the bearing plate in a supine position, the suspension rope suspends the upper teeth of the mouse to fix the mouse, an illuminating mechanism used for illuminating the inside of the oral cavity of the mouse is arranged on the mounting plate and comprises a sliding rail and a lamp cylinder, the sliding rail is arranged in parallel with the bearing plate, a sliding groove is arranged on one surface of the sliding rail facing the bearing plate, a sliding block is arranged at one end of the lamp cylinder and is connected with the sliding groove in a sliding manner, a lamp holder used for tightly attaching to the skin at the neck of the mouse is arranged at, the moving mechanism drives the sliding block to move along the sliding groove, and the mounting plate is further provided with a rotating mechanism for adjusting the inclination of the sliding rail and the inclination of the bearing plate simultaneously.

As a further development of the invention, the turning mechanism comprises a first turning shaft, a second turning shaft, a turning rod, a first bevel gear, a second bevel gear, and two third bevel gears, the first rotating shaft and the second rotating shaft vertically penetrate through the mounting plate, one end of the first rotating shaft is fixedly connected with the bearing plate, the other end of the rotating rod is connected with a first bevel gear, one end of the second rotating shaft is fixedly connected with a sliding rail, the other end of the rotating rod is connected with a second bevel gear, the rotating rod is rotatably arranged on the bottom plate, is parallel to the mounting plate, the two third bevel gears are fixedly sleeved on the rotating rod and are respectively used for being meshed with the first bevel gear and the second bevel gear to rotate, when the rotating rod rotates, the two third bevel gears rotate, the first bevel gear and the second bevel gear rotate simultaneously in the same direction, the bearing plate and the sliding rail rotate simultaneously at the same angle, and the position of the lamp cap relative to the mouse is kept unchanged.

As a further improvement of the invention, the moving mechanism comprises a slide bar, a first sleeve ring, a second sleeve ring and a connecting piece, one end of the slide bar is connected to one surface of the slide bar, which is opposite to the slide groove, while the other end extends opposite to the slide groove, the first sleeve ring is slidably sleeved on the slide bar, the second sleeve ring is slidably sleeved on the lamp tube, one end of the connecting piece is connected to the first sleeve ring, while the other end is connected to the second sleeve ring, when the connecting piece moves away from the slide rail, the first sleeve ring moves away from the slide rail along the slide bar, the second sleeve ring moves away from the bearing plate, and the lamp tube moves towards the bottom plate along.

As a further improvement of the invention, the first lantern ring is further provided with a fixing mechanism for locking the first lantern ring, the fixing mechanism comprises an inserting plate, an inserting rod and a spring, one end of the spring is connected to the inserting plate, the other end of the spring is connected to one surface of the first lantern ring facing the inserting plate, the first lantern ring is provided with a first through hole, the sliding rod is provided with a plurality of second through holes, and the inserting rod is arranged on one surface of the inserting plate facing the first lantern ring and penetrates into the first through hole and one of the second through holes.

As a further improvement of the invention, one end of the lamp tube, which is far away from the lamp holder, is provided with a groove, one surface of the sliding block, which is back to the sliding groove, is provided with a convex block, the inner wall of the groove is provided with a first thread, and the convex block is provided with a second thread which is in threaded connection with the first thread.

As a further improvement of the invention, the suspension rope is a rubber band.

The invention has the beneficial effects that: when a mouse trachea cannula experiment needs to be carried out, an anesthetized mouse is placed on a bearing plate, the upper teeth of the mouse are hung on a suspension line, so that the mouse can be fixed on the inclined bearing plate in a supine manner, a follow-up operator can conveniently pull the tongue root of the mouse to expose the trachea inside the oral cavity of the mouse, at the moment, the operator can further fix the four limbs of the mouse by using an adhesive tape according to actual conditions, a lamp cap of a lamp tube in an illuminating mechanism is tightly attached to the body surface of the mouse, the left hand of the operator holds the tongue of the mouse to be pulled outwards to expose the oral cavity of the mouse, the right hand starts a moving mechanism to enable a sliding block to slide in a sliding groove, the lamp cap moves to the skin of the neck of the mouse, the inside of the oral cavity is illuminated by means of light penetrating through the neck, and when the brightness in the oral cavity reaches the degree of clearly seeing the trachea position in the oral cavity, the invention can clearly see the position of the trachea in the oral cavity of the mouse by arranging the lighting mechanism, can liberate one hand for next operation after the brightness adjustment of the oral cavity of the mouse is finished by the moving mechanism, does not need to hold the lamp tube all the time by arranging the rotating mechanism, simultaneously adjusts the inclination of the sliding rail and the inclination of the bearing plate, does not change the brightness of the oral cavity of the mouse all the time in the rotating process, and can still clearly see the trachea in the oral cavity of the mouse after rotating, meanwhile, the optimal visual angle for facilitating the insertion of the trachea into the mouse trachea is obtained after rotation, and then the last intubation is carried out, so that the success rate of the experiment is improved, and the experiment is conveniently carried out by an operator independently.

Drawings

FIG. 1 is a partial cross-sectional elevation view of the present invention;

FIG. 2 is a perspective view of the illumination mechanism and the movement mechanism;

FIG. 3 is a left side view of the present invention;

FIG. 4 is a right side view of the present invention;

FIG. 5 is another angular view of the rotating mechanism of the present invention;

fig. 6 is an enlarged view at a in fig. 1.

Reference numerals: 1. a base plate; 2. mounting a plate; 3. a bearing plate; 4. a suspension cord; 5. an illumination mechanism; 51. a slide rail; 52. a lamp barrel; 510. a chute; 53. a slider; 54. a lamp cap; 6. a moving mechanism; 61. a slide bar; 62. a first collar; 63. a second collar; 64. a connecting member; 7. a rotating mechanism; 71. a first rotating shaft; 72. a second rotating shaft; 73. rotating the rod; 74. a first bevel gear; 75. a second bevel gear; 76. a third bevel gear; 8. a fixing mechanism; 81. inserting plates; 82. inserting a rod; 83. a spring; 84. a first through hole; 85. a second through hole; 91. a groove; 92. and (4) a bump.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings and examples. In which like parts are designated by like reference numerals.

Referring to fig. 1 to 6, the experimental device for tracheal intubation of a mouse of the present embodiment includes a bottom plate 1, a mounting plate 2, and a bearing plate 3, wherein one end of the mounting plate 2 is connected to the bottom plate 1, the other end extends back to the bottom plate 1, the bearing plate 3 is rotatably disposed on the mounting plate 2, the bearing plate 3 is inclined relative to a horizontal plane, a suspension rope 4 is disposed on the bearing plate 3, when the mouse lies on the back on the bearing plate 3, the suspension rope 4 suspends the upper teeth of the mouse to fix the mouse, an illumination mechanism 5 for illuminating the inside of the oral cavity of the mouse is disposed on the mounting plate 2, the illumination mechanism 5 includes a slide rail 51 and a lamp cylinder 52, the slide rail 51 is disposed parallel to the bearing plate 3, a sliding groove 510 is disposed on a surface of the slide rail 51 facing the bearing plate 3, a sliding block 53 is disposed on one end of the lamp cylinder 52, and, the lamp holder 54 used for tightly adhering to the neck skin of a mouse is arranged at one end, close to the bearing plate 3, of the lamp cylinder 52, the sliding rail 51 is provided with a moving mechanism 6 used for moving the lamp cylinder 52, the moving mechanism 6 drives the sliding block 53 to move along the sliding groove 510, and the mounting plate 2 is further provided with a rotating mechanism 7 used for simultaneously adjusting the inclination of the sliding rail 51 and the inclination of the bearing plate 3.

Through the technical scheme: when a mouse trachea cannula experiment needs to be carried out, an anesthetized mouse is placed on the bearing plate 3, the upper teeth of the mouse are hung on the suspension line, so that the mouse can be fixed on the inclined bearing plate 3 in a supine manner, a follow-up operator can conveniently pull the tongue root of the mouse to expose the trachea inside the oral cavity of the mouse, at the moment, the operator can further fix the limbs of the mouse by using an adhesive tape according to actual conditions, the lamp head 54 of the lamp tube 52 in the illuminating mechanism 5 is tightly attached to the body surface of the mouse, the left hand of the operator holds the tongue of the mouse to pull outwards so as to expose the oral cavity of the mouse, the right hand starts the moving mechanism 6 to enable the sliding block 53 to slide in the sliding groove 510, the lamp head 54 moves to the skin at the neck of the mouse, the inside of the oral cavity is illuminated by means of light penetrating through the neck, and the operation on the moving mechanism 6 is released by the right hand until the brightness in the oral cavity reaches, the rotating mechanism 7 is started to drive the bearing plate 3 and the slide rail 51 to rotate at the same angle at the same time, until an operator obtains an optimal visual angle convenient for inserting the trachea into the trachea of the mouse, the operation of the rotating mechanism 7 is cancelled, at the moment, the position of the lamp head 54 relative to the mouse is unchanged, the lamp head 54 is still tightly attached to the same position of the neck skin of the mouse, the position of the trachea in the oral cavity of the mouse can still be seen clearly, and then the final intubation is carried out, the position of the trachea in the oral cavity of the mouse can be seen clearly by arranging the illuminating mechanism 5, after the brightness adjustment in the oral cavity of the mouse is finished by the moving mechanism 6, one hand can be liberated to carry out the next operation without holding the lamp tube 52 all the time, the brightness in the oral cavity of the mouse is not changed all the time by arranging the rotating mechanism 7 and simultaneously adjusting the inclination of the slide rail 51 and the inclination of the bearing, make and still can see the inside trachea of mouse oral cavity clearly after rotating, simultaneously, obtain the best visual angle that makes things convenient for the trachea to insert mouse trachea after rotating, carry out last intubate again, improved the success rate of experiment, also make things convenient for the operator to carry out the experiment alone.

As a modified specific embodiment, the rotating mechanism 7 includes a first rotating shaft 71, a second rotating shaft 72, a rotating rod 73, a first bevel gear 74, a second bevel gear 75, and two third bevel gears 76, the first rotating shaft 71 and the second rotating shaft 72 both vertically penetrate through the mounting plate 2, one end of the first rotating shaft 71 is fixedly connected to the bearing plate 3, the other end is connected to the first bevel gear 74, one end of the second rotating shaft 72 is fixedly connected to the sliding rail 51, the other end is connected to the second bevel gear 75, the rotating rod 73 is rotatably disposed on the base plate 1 and parallel to the mounting plate 2, the two third bevel gears 76 are fixedly sleeved on the rotating rod 73, the two third bevel gears 76 are respectively used for meshing rotation with the first bevel gear 74 and the second bevel gear 75, when the rotating rod 73 rotates, the two third bevel gears 76 rotate, the first bevel gear 74 and the second bevel gear 75 rotate at the same time and have the same rotating direction, the bearing plate 3 and the slide rail 51 rotate at the same time by the same angle, and the position of the lamp head 54 relative to the mouse is kept unchanged.

Through the technical scheme: when the rotating mechanism 7 is started, the rotating rod 73 is rotated, and the two third bevel gears 76 on the rotating rod 73 are respectively meshed with the first bevel gear 74 and the second bevel gear 75 to rotate, so that the first bevel gear 74 and the second bevel gear rotate simultaneously, and the rotating directions are the same, so that the bearing plate 3 and the sliding rail 51 are driven to rotate at the same angle.

As a modified specific embodiment, the moving mechanism 6 includes a sliding rod 61, a first collar 62, a second collar 63 and a connecting member 64, one end of the sliding rod 61 is connected to a surface of the sliding rail 51 facing away from the sliding groove 510, the other end extends away from the sliding groove 510, the first collar 62 is slidably sleeved on the sliding rod 61, the second collar 63 is slidably sleeved on the lamp tube 52, one end of the connecting member 64 is connected to the first collar 62, the other end is connected to the second collar 63, when the connecting member 64 is far away from the sliding rail 51 and moves, the first collar 62 is far away from the sliding rail 51 along the sliding rod 61 and moves, the second collar 63 is far away from the bearing plate 3 and moves, and the lamp tube 52 moves toward the bottom plate 1 along the sliding groove 510.

Through the technical scheme: when the brightness in the oral cavity of the mouse needs to be adjusted, the position of the connecting piece 64 is moved, when the connecting piece 64 is moved away from the sliding rail 51 manually, the first sleeve is moved away from the sliding rail 51 along the sliding rod 61, the second sleeve 63 is moved away from the bearing plate 3, the lamp tube 52 is moved towards the bottom plate 1 along the sliding groove 510, the lamp head 54 is moved downwards along the skin of the neck of the mouse, the brightness in the oral cavity of the mouse is reduced, when the connecting piece 64 is moved close to the sliding rail 51, the first sleeve is moved towards the sliding rail 51 along the sliding rod 61, the second sleeve 63 is moved towards the bearing plate 3, the lamp tube 52 is moved towards the bottom plate 1 along the sliding groove 510, the lamp head 54 is moved upwards along the skin of the neck of the mouse, and the brightness in the oral cavity of.

As a modified specific embodiment, the first collar 62 is further provided with a fixing mechanism 8 for locking the first collar 62, the fixing mechanism 8 includes an insertion plate 81, an insertion rod 82 and a spring 83, one end of the spring 83 is connected to the insertion plate 81, the other end of the spring is connected to a surface of the first collar 62 facing the insertion plate 81, the first collar 62 is provided with a first through hole 84, the slide rod is provided with a plurality of second through holes 85, and the insertion rod 82 is arranged on a surface of the insertion plate 81 facing the first collar 62 and penetrates into the first through hole 84 and one of the second through holes 85.

Through the technical scheme: in the initial state, the insertion rod 82 is placed in the first through hole 84 on the first sleeve and one second through hole 85 on the sliding rod 61, when the position of the lamp cylinder 52 in the sliding groove 510 needs to be changed, the insertion plate 81 is manually moved, the spring 83 is stretched, the insertion rod 82 is moved out of the first through hole 84 and the second through hole 85, the connecting piece 64 is moved, when the lamp cylinder 52 is moved to a proper position, the insertion plate 81 is released from being held, and the insertion rod 82 is positioned in the first through hole 84 and the next second through hole 85 through the contraction of the spring 83.

In a modified specific embodiment, a groove 91 is provided at an end of the lamp barrel 52 away from the lamp head 54, a protrusion 92 is provided on a surface of the slider 53 facing away from the sliding groove 510, a first thread is provided on an inner wall of the groove 91, and a second thread for threaded connection with the first thread is provided on the protrusion 92.

Through the technical scheme: through the first screw thread on recess 91 and the second screw thread on the lug 92 for lamp section of thick bamboo 52 threaded connection is on slider 53, and lamp section of thick bamboo 52 can be dismantled, conveniently changes, and in addition, the distance between lamp section of thick bamboo 52 and bearing plate 3 is adjustable, is adapted to the mouse of different sizes.

As a modified specific embodiment, the suspension rope 4 is a rubber band.

Through the technical scheme: the rubber band is a common elastic material, and compared with the rigid suspension rope 4, the rubber band is more suitable for mice with different body types, and after the step of inserting the intubation tube into the trachea of the mouse is completed, the mouse is conveniently taken down through elasticity.

The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.

Claims

1. The utility model provides a be used for mouse trachea cannula experimental apparatus which characterized in that: comprises a bottom plate (1), a mounting plate (2) and a bearing plate (3), one end of the mounting plate (2) is connected on the bottom plate (1), the other end of the mounting plate extends towards the bottom plate (1), the bearing plate (3) is rotatably arranged on the mounting plate (2), the bearing plate (3) is inclined relative to the horizontal plane, a suspension rope (4) is arranged on the bearing plate (3), when a mouse lies on the back on the bearing plate (3), the suspension rope (4) suspends the mouse and fixes the mouse, an illuminating mechanism (5) used for illuminating the inside of the oral cavity of the mouse is arranged on the mounting plate (2), the illuminating mechanism (5) comprises a sliding rail (51) and a lamp tube (52), the sliding rail (51) and the bearing plate (3) are arranged in parallel, a sliding groove (510) is arranged on one surface of the sliding rail (51) facing the bearing plate (3), a sliding block (53) is arranged on one end of the lamp tube (52, the sliding block (53) is connected with the sliding groove (510) in a sliding mode, a lamp holder (54) used for being tightly attached to the neck skin of a mouse is arranged at one end, close to the bearing plate (3), of the lamp barrel (52), a moving mechanism (6) used for moving the lamp barrel (52) is arranged on the sliding rail (51), the moving mechanism (6) drives the sliding block (53) to move along the sliding groove (510), and a rotating mechanism (7) used for adjusting the inclination of the sliding rail (51) and the inclination of the bearing plate (3) simultaneously is further arranged on the mounting plate (2);

slewing mechanism (7) include first pivot (71), second pivot (72), dwang (73), first bevel gear (74), second bevel gear (75) and two third bevel gears (76), mounting panel (2) is all passed perpendicularly in first pivot (71) and second pivot (72), first pivot (71) one end fixed connection bearing plate (3), first bevel gear (74) is connected to one end in addition, second pivot (72) one end fixed connection slide rail (51), and second bevel gear (75) is connected to other one end, dwang (73) rotate and set up on bottom plate (1), and is parallel with mounting panel (2), two third bevel gear (76) fixed cover is established on dwang (73), two third bevel gear (76) are used for respectively with first bevel gear (74), second bevel gear (75) meshing rotation, when the rotating rod (73) rotates, the two third bevel gears (76) rotate, the first bevel gear (74) and the second bevel gear (75) rotate simultaneously in the same direction, the bearing plate (3) and the sliding rail (51) rotate simultaneously at the same angle, and the position of the lamp head (54) relative to the mouse is kept unchanged.

2. The experimental device for mouse trachea intubation according to claim 1, wherein: moving mechanism (6) include slide bar (61), the first lantern ring (62), the second lantern ring (63) and connecting piece (64), slide bar (61) one end is connected on the one side of slide rail (51) spout (510) dorsad, and the other end extends spout (510) dorsad, the slip cover of first lantern ring (62) is established on slide bar (61), the slip cover of second lantern ring (63) is established on lamp section of thick bamboo (52), connecting piece (64) one end is connected on the first lantern ring (62), and the other end is connected on the second lantern ring (63), when slide rail (51) removal is kept away from in connecting piece (64), slide rail (51) removal is kept away from along slide bar (61) to the first lantern ring (62), bearing plate (3) removal is kept away from to the second lantern ring (63), and lamp section of thick bamboo (52) are removed to bottom plate (1) along spout (510).

3. The experimental device for mouse trachea intubation according to claim 2, wherein: still be provided with fixed establishment (8) that are used for locking first lantern ring (62) on first lantern ring (62), fixed establishment (8) are including picture peg (81), inserted bar (82) and spring (83), spring (83) one end is connected on picture peg (81), and the other end is connected in first lantern ring (62) towards the one side of picture peg (81), there are first through-hole (84) on first lantern ring (62), be provided with a plurality of second through-hole (85) on slide bar (61), inserted bar (82) set up in picture peg (81) towards the one side of first lantern ring (62) to penetrate in first through-hole (84) and one of them second through-hole (85).

4. The experimental device for mouse trachea intubation according to claim 1, wherein: a groove (91) is formed in one end, far away from the lamp holder (54), of the lamp barrel (52), a protruding block (92) is arranged on one face, back to the sliding groove (510), of the sliding block (53), first threads are arranged on the inner wall of the groove (91), and second threads used for being in threaded connection with the first threads are arranged on the protruding block (92).

5. The experimental device for mouse trachea intubation according to claim 1, wherein: the suspension rope (4) is a rubber band.