CN109452708A - A kind of method of preparation and use of graphene lumbar medicinal waistband - Google Patents
A kind of method of preparation and use of graphene lumbar medicinal waistband Download PDFInfo
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- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41F—GARMENT FASTENINGS; SUSPENDERS
- A41F9/00—Belts, girdles, or waistbands for trousers or skirts
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
The invention proposes a kind of graphene lumbar medicinal waistband, including outer layer and internal layer splicing tape, the side bonds graphene Traditional Chinese medicine gel packet in waistband, the graphene Traditional Chinese medicine gel packet is prepared in accordance with the following steps: (1) pueraria lobata, rhizoma curcumae longae concisa, the root of Chinese clematis, Rhizoma Chuanxiong being taken to crush, ethyl alcohol impregnates, and is concentrated, clarification, decoloration, upper macroporous absorbent resin elutes, concentration, it is dry, obtain Chinese medical extract;(2) by Graphene powder ultrasonic disperse in Chinese medical extract aqueous solution, strong stirring is added dropwise gelatin solution, continues to be sufficiently stirred, stand after being thoroughly mixed, and obtains graphene-gelatin and carries liquid medicine gel;(3) product of step (2) is poured into mold, solidification sizing is fitted into the bonded ventilative woven fabric band of one side, seals, is made.Chinese medical extract in conjunction with grapheme material, is prepared into hydrogel dosage form by the present invention, can play the drug effect of composition to greatest extent, is absorbed convenient for patient, is reached good treatment lumbar pain effect.
Description
Technical field
The present invention relates to medicament girdle technical fields, and in particular to a kind of graphene lumbar medicinal waistband.
Background technique
Lumbar pain is since relatively common has waist hyperosteogeny, spur, the protrusion of the intervertebral disc, lumbar vertebrae hypertrophy, vertebra
The diseases such as narrow, waist fracture, tumor in vertebral canal, waist acute and chronic wound or strain, lumbar muscle strain, ankylosing spondylitis are managed to cause
Flank pain.There are many reason of causing lumbar vertebra pain, and there are about tens of kinds, relatively common has waist hyperosteogeny, spur, intervertebral
It is disc protrusion, lumbar vertebrae hypertrophy, spinal canal stenosis, waist fracture, tumor in vertebral canal, waist acute and chronic wound or strain, lumbar muscle strain, strong
Straightforward rachitis etc..In traditional concept, the chronic back pain after general inspection excludes disease factor is often taken as " psoas muscle labor
Damage ", in fact, what 4 one-tenth pain in the loins persons suffered from is Chronic compartment syndrome, but due to cannot get symptomatic treatment and for a long time by waist
Pain perplexs.Many patients have the pain in the loins of long period, what disease is someone's even pain do not know for 50 years also.Pain in the loins becomes younger
Gesture is it is also obvious that somebody 18 years old has just suffered from this disease.
The small of the back is that human body exerts oneself most positions, to provide support for human body and protect backbone, to long in office for a long time
The people for sitting and lacking exercise, or because of the people that need of work is stood long, maintain a position or posture too long for a long time, be easy for
It causes the pain of the small of the back and causes lumbosacral region Chronic compartment syndrome, also have plenty of and accumulate hair after repeated injury
Disease.Many chronic back pain patients are related with Chronic compartment syndrome, and reason may be that the raising of bone fixation internal pressure is led
Gap under lumbodorsal fascia is caused to disappear, the decline of muscle blood flow amount, loose adipose tissue denaturation.Due to this damage, patient is caused
Either walk, sit more it is still mostly sleeping, all can Low Back Pain, i.e., keep a kind of posture to be easy to produce Low Back Pain for a long time.This is chronic bone
The important clinical feature of fixation syndrome.
Traditional waistband only has the simple functions fastened with decoration.The magnetic waistband occurred in recent years to body-care with
Certain effect has been controlled in the treatment of waist disease, but single to the ill, and effectiveness is weak relative to the direct digital display of Traditional chinese medicine medicament paste.But Traditional chinese medicine medicament cream class
Easy to pollute when use, skin absorption efficiency is low, also shorter using the time.Therefore, the present invention by graphene-supported Chinese medicine effectively at
Point, it is prepared into gelling agent, as distributing for skin moisture penetrates into drug, absorptivity is high, is not easy to cause skin discomfort and graphite
Alkene Traditional Chinese medicine gel packet is detachable, and waistband can be recycled, save the cost.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of graphene lumbar medicinal waistband and its preparation, and mentions
Its application method is supplied, for this method by the composition of Chinese medicine treatment lumbar pain in conjunction with grapheme material, it is special to prepare
Graphene-based hydrogel dosage form, is applied on emplastrum, and physical structure and chemical effective component combine, and can play to greatest extent
Chinese medicine treats the drug effect of the composition of lumbar pain, absorbs convenient for patient, reaches good therapeutic effect.
The present invention provides a kind of graphene lumbar medicinal waistband, including outer layer and internal layer splicing tape, which is characterized in that
The preparation of the side bonds graphene Traditional Chinese medicine gel packet in waistband, the graphene Traditional Chinese medicine gel packet carries out in accordance with the following steps:
(1) extraction of medicinal material: taking pueraria lobata, rhizoma curcumae longae concisa, the root of Chinese clematis, Rhizoma Chuanxiong, crushes, the alcohol solution dipping of 40%-70%
3h impregnates 1-3 times, merges percolate, is concentrated under reduced pressure, and clarifies, and decoloration, upper AB-8 macroporous absorbent resin, 30%-70% ethyl alcohol is washed
De-, eluent is concentrated under reduced pressure, dry, obtains Chinese medical extract;
(2) preparation of graphene base load medicinal gel: Graphene powder is dispersed in 1L Chinese medical extract aqueous solution, ultrasonic 1h
Graphene dispersing solution is obtained, strong stirring is added dropwise 1L gelatin solution, continues that 1h is sufficiently stirred, stand after being mixed thoroughly
For 24 hours, discharge bubble obtains graphene-gelatin and carries liquid medicine gel;
(3) preparation of graphene Traditional Chinese medicine gel packet: the graphene of step (2)-gelatin is carried into liquid medicine gel and is stirred evenly,
Enter in mold, is put into 0-4 DEG C of solidification sizing 24-48h of refrigerator, is fitted into the bonded ventilative woven fabric band of one side, stone is made in sealing
Black alkene Traditional Chinese medicine gel packet.
Improved as of the invention further, graphene Traditional Chinese medicine gel packet content prepared by following raw material and
At: 15-30 parts of pueraria lobata, 10-15 parts of rhizoma curcumae longae concisa, 10-15 parts of the root of Chinese clematis, 10-15 parts of Rhizoma Chuanxiong, 5-10 parts of gelatin, graphene 0.01-
1 part.
Improved as of the invention further, graphene Traditional Chinese medicine gel packet content prepared by following raw material and
At: 30 parts of pueraria lobata, 15 parts of rhizoma curcumae longae concisa, 15 parts of the root of Chinese clematis, 12 parts of Rhizoma Chuanxiong, 10 parts of gelatin, 0.1 part of graphene.
As further improvement of the invention, AB-8 resin can be in NKA-9, X-5, D-101, S-8, D16, D4020
A kind of substitution.
It is improved as of the invention further, concentration of alcohol is 60% when immersion, and concentration of alcohol is 50% when elution.
Improved as of the invention further, Chinese medical extract aqueous solution according to Chinese medical extract and water weight ratio 1:50
It configures.
As further improvement of the invention, graphene Traditional Chinese medicine gel packet is detachable.
The present invention further protects a kind of application method of above-mentioned graphene lumbar medicinal waistband, and the method is according to following
Step carries out:
(1) the graphene Traditional Chinese medicine gel packet being prepared into is adhered in the middle part of waistband internal layer splicing tape;
(2) it will be directed at afflicted area in the middle part of waistband internal layer, around one circle of waist winding, both ends are adhesively fixed.
The present invention further protects a kind of above-mentioned graphene lumbar medicinal waistband for treating the application of lumbar pain.
The invention has the following beneficial effects:
1, the spies such as graphene-gelatin hydrogel prepared by the present invention has water absorbing force strong, and drugloading rate is high, and chemical property is stablized
Point, being applied in retreat stickers has the characteristics that rapid-action, the medicinal time is lasting;
2, graphene Traditional Chinese medicine gel packet of the present invention is detachable, save the cost;
3, crude drug source of the present invention is wide, low in cost, and production method is simple, industrialization easy to accomplish.
Detailed description of the invention
Fig. 1 is graphene lumbar medicinal belt knot composition;
In figure, 1. outer layers;2. internal layer splicing tape;3. graphene Traditional Chinese medicine gel packet.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, the embodiment described is the embodiment of part of representative of the invention, rather than whole embodiments, this field are general
Other all embodiments obtained belong to protection of the invention to logical technical staff without making creative work
Range.
The preparation of 1 graphene Traditional Chinese medicine gel packet of embodiment
Raw material composition: 15 parts of pueraria lobata, 10 parts of rhizoma curcumae longae concisa, 10 parts of the root of Chinese clematis, 10 parts of Rhizoma Chuanxiong, 5 parts of gelatin, graphene 0.01
Part.
It carries out in accordance with the following steps:
(1) extraction of medicinal material: taking pueraria lobata, rhizoma curcumae longae concisa, the root of Chinese clematis, Rhizoma Chuanxiong, crushes, 70% alcohol solution dipping 3h, leaching
Bubble 3 times merges percolate, is concentrated under reduced pressure, and clarifies, decoloration, upper AB-8 macroporous absorbent resin, 70% ethanol elution, and eluent subtracts
Pressure concentration, it is dry, obtain Chinese medical extract, yield 56%;
(2) preparation of graphene base load medicinal gel: Graphene powder is dispersed in 1L Chinese medical extract aqueous solution, Chinese medicine mentions
Taking the weight ratio of object and water is 1:100, and ultrasonic 1h obtains graphene dispersing solution, and strong stirring is added dropwise 1L gelatin solution, continues to fill
Divide stirring 1h, stood after being mixed thoroughly for 24 hours, discharge bubble obtains graphene-gelatin and carries liquid medicine gel;
(3) preparation of graphene Traditional Chinese medicine gel packet: the graphene of step (2)-gelatin is carried into liquid medicine gel and is stirred evenly,
Enter in mold, is put into 4 DEG C of solidification sizing 48h of refrigerator, is fitted into the bonded ventilative woven fabric band of one side, graphene is made in sealing
Traditional Chinese medicine gel packet.
The preparation of 2 graphene Traditional Chinese medicine gel packet of embodiment
Raw material composition: 20 parts of pueraria lobata, 12 parts of rhizoma curcumae longae concisa, 12 parts of the root of Chinese clematis, 10 parts of Rhizoma Chuanxiong, 7 parts of gelatin, 1 part of graphene.
It carries out in accordance with the following steps:
(1) extraction of medicinal material: taking pueraria lobata, rhizoma curcumae longae concisa, the root of Chinese clematis, Rhizoma Chuanxiong, crushes, 40% alcohol solution dipping 3h, leaching
Bubble 3 times merges percolate, is concentrated under reduced pressure, and clarifies, decoloration, upper D-101 macroporous absorbent resin, 30% ethanol elution, and eluent subtracts
Pressure concentration, it is dry, obtain Chinese medical extract, yield 76%;
(2) preparation of graphene base load medicinal gel: Graphene powder is dispersed in 1L Chinese medical extract aqueous solution, Chinese medicine mentions
Taking the weight ratio of object and water is 1:30, and ultrasonic 1h obtains graphene dispersing solution, and strong stirring is added dropwise 1L gelatin solution, continues to fill
Divide stirring 1h, stood after being mixed thoroughly for 24 hours, discharge bubble obtains graphene-gelatin and carries liquid medicine gel;
(3) preparation of graphene Traditional Chinese medicine gel packet: the graphene of step (2)-gelatin is carried into liquid medicine gel and is stirred evenly,
Enter in mold, is put into 4 DEG C of solidification sizing 36h of refrigerator, is fitted into the bonded ventilative woven fabric band of one side, graphene is made in sealing
Traditional Chinese medicine gel packet.
The preparation of 3 graphene Traditional Chinese medicine gel packet of embodiment
Raw material composition: 30 parts of pueraria lobata, 15 parts of rhizoma curcumae longae concisa, 15 parts of the root of Chinese clematis, 12 parts of Rhizoma Chuanxiong, 10 parts of gelatin, graphene 0.1
Part.
It carries out in accordance with the following steps:
(1) extraction of medicinal material: taking pueraria lobata, rhizoma curcumae longae concisa, the root of Chinese clematis, Rhizoma Chuanxiong, crushes, 60% alcohol solution dipping 3h, leaching
Bubble 3 times merges percolate, is concentrated under reduced pressure, and clarifies, decoloration, upper D-101 macroporous absorbent resin, 50% ethanol elution, and eluent subtracts
Pressure concentration, it is dry, obtain Chinese medical extract, yield 92%;
(2) preparation of graphene base load medicinal gel: Graphene powder is dispersed in 1L Chinese medical extract aqueous solution, Chinese medicine mentions
Taking the weight ratio of object and water is 1:50, and ultrasonic 1h obtains graphene dispersing solution, and strong stirring is added dropwise 1L gelatin solution, continues to fill
Divide stirring 1h, stood after being mixed thoroughly for 24 hours, discharge bubble obtains graphene-gelatin and carries liquid medicine gel;
(3) preparation of graphene Traditional Chinese medicine gel packet: the graphene of step (2)-gelatin is carried into liquid medicine gel and is stirred evenly,
Enter in mold, is put into 4 DEG C of solidification sizings of refrigerator for 24 hours, is fitted into the bonded ventilative woven fabric band of one side, graphene is made in sealing
Traditional Chinese medicine gel packet.
The preparation of 4 graphene lumbar medicinal waistband of embodiment
A kind of graphene lumbar medicinal waistband, specific structure part attached drawing, including outer layer 1 and internal layer splicing tape 2, will be of the invention
Graphene Traditional Chinese medicine gel packet 3 prepared by embodiment 3 be bonded on the inside of waistband to get.
The extract of 1 Chinese medicine composition conventional method of reference examples preparation
Raw material composition: 30 parts of pueraria lobata, 15 parts of rhizoma curcumae longae concisa, 15 parts of the root of Chinese clematis, 12 parts of Rhizoma Chuanxiong.
It follows the steps below:
(1) it takes pueraria lobata, rhizoma curcumae longae concisa, the root of Chinese clematis, Rhizoma Chuanxiong to mix after crushing by weight, 10 times of volume of water is added, impregnate
30min decocts 3h, is filtered under diminished pressure, filtrate is spare;
(2) 5 times of volume of water are added in the dregs of a decoction obtained by step (1), decoct 2h, is filtered under diminished pressure, filtrate is spare;
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 meshes, concentration filtrate to relative density 0.9-
1.3, to get Chinese medicine composition water extract, add auxiliary material, are prepared into transdermal patch.
2 Chinese medicine composition ordinary gel agent of reference examples
Raw material composition: 30 parts of pueraria lobata, 15 parts of rhizoma curcumae longae concisa, 15 parts of the root of Chinese clematis, 12 parts of Rhizoma Chuanxiong, 10 parts of gelatin.
It follows the steps below:
(1) extraction of medicinal material: taking pueraria lobata, rhizoma curcumae longae concisa, the root of Chinese clematis, Rhizoma Chuanxiong to crush, and 60% alcohol solution dipping 3h impregnates
1-3 times, merge percolate, be concentrated under reduced pressure, clarification is decolourized, upper D-101 macroporous absorbent resin, 50% ethanol elution, and eluent subtracts
Pressure concentration, it is dry, obtain Chinese medical extract, yield 92%;
(2) Chinese medical extract of step (1) preparation and water are dissolved in water by weight 1:50, gelatin is added dropwise in strong stirring
Solution continues that 1h is sufficiently stirred, and stands after being mixed thoroughly for 24 hours, and discharge bubble obtains Chinese medicine composition hydrogel, adds auxiliary
Material, is prepared into transdermal patch.
1 human trial of test example
1, group is tested.It is divided into 4 groups, traditional Chinese medicine composition water prepared by reference examples 1 proposes patch group (1 group of control), reference examples 2 are made
It is prepared by standby Chinese medicine composition ordinary gel patch group (2 groups of control), QIZHENG XIAOTONG TIE group (3 groups of control) and the embodiment of the present invention 4
Graphene lumbar medicinal waistband (experimental group).
2, experimental method.
(1) case selection.80, the month the court 1-12 lumbar vertebrae patients during peri in 2017 is chosen as research object, according to
Random digits table is classified as 4 groups, every group 20.Wherein compare 1 group male 12, female 8, the age 32-59 years old, average age
48.21 years old.Compare 2 groups of male 10, female 10, the age 35-62 years old, average age 51.22 years old.Compare 3 groups male 8, female 12,
Age 32-58 years old, average age 48.27 years old.Experimental group male 11, female 9, the age 34-60 years old, average age 49.87 years old.
Inclusion criteria: lumbar vertebrae patients during peri is 1. selected;2. the patient that excludes insanity, can not cooperate;3. arranging
Except the patient for merging serious organic disease.
(2) treatment method.It compares 1 group and patch is mentioned using traditional Chinese medicine composition water prepared by reference examples 1, compare 2 groups using control
Chinese medicine composition ordinary gel patch prepared by example 2,3 groups of control use QIZHENG XIAOTONG TIE.Patch is affixed on flank pain position.Experiment
The graphene lumbar medicinal waistband that group is prepared using the embodiment of the present invention 4 will be directed at afflicted area in the middle part of waistband internal layer, surround waist
One circle of portion's winding, both ends are adhesively fixed.
(3) observation index and evaluation criterion.Observe the pretherapy and post-treatment VAS scoring of four groups of patients, life quality scores and ridge
Column function score.
Evaluated using pain degree of the VAS to patient, main standard is as follows: patient does not feel that pain is denoted as 0 point;
The patient feels are denoted as 1-3 points to mild pain;The patient feels are denoted as 4-6 points to moderate pain;The patient feels are remembered to severe pain
It is 7-10 points.
Spinal function scoring content specifically includes that clinical symptoms, work and viability, lower limb function and clinical body
Sign, score is higher, shows that patient spine function is better.
Experimental result is shown in Table 1.
1 four groups of life quality scores of table, VAS scoring event and spinal function scoring are compared
It can be seen from the above result that trouble can not be effectively relieved in traditional QIZHENG XIAOTONG TIE for lumbar pain patient
The pain of person generates strong influence to the quality of life of patient.The graphene lumbar medicinal prepared using the embodiment of the present invention 4
Waistband is absorbed by the way that grapheme material in conjunction with drug extract, to be prepared into drugloading rate greatly and is played convenient for drug effect with patient
Hydrogel, can not only effectively mitigate the clinical symptoms of patient, simultaneously, additionally it is possible to which the unhealthy emotion of further reduction of patient is anti-
It answers, reduces the stimulation of patient's physiological pain bring, clinical nursing effect is best, is significantly better than the Chinese traditional medicine composition of the preparation of reference examples 1
Object water proposes Chinese medicine composition ordinary gel patch prepared by patch and reference examples 2.
Those skilled in the art is not under conditions of departing from the spirit and scope of the present invention that claims determine, also
Various modifications can be carried out to the above content.Therefore the scope of the present invention is not limited in above explanation, but by
The range of claims determines.
Claims (9)
1. a kind of graphene lumbar medicinal waistband, including outer layer and internal layer splicing tape, which is characterized in that the side bonds stone in waistband
The preparation of black alkene Traditional Chinese medicine gel packet, the graphene Traditional Chinese medicine gel packet carries out in accordance with the following steps:
(1) extraction of medicinal material: taking pueraria lobata, rhizoma curcumae longae concisa, the root of Chinese clematis, Rhizoma Chuanxiong, crushes, the alcohol solution dipping 3h of 40%-70%, leaching
Bubble 1-3 times merges percolate, is concentrated under reduced pressure, and clarifies, and decoloration, upper AB-8 macroporous absorbent resin, 30%-70% ethanol elution is washed
De- liquid is concentrated under reduced pressure, dry, obtains Chinese medical extract;
(2) preparation of graphene base load medicinal gel: Graphene powder is dispersed in 1L Chinese medical extract aqueous solution, ultrasonic 1h is obtained
Graphene dispersing solution, strong stirring are added dropwise 1L gelatin solution, continue that 1h is sufficiently stirred, and stand after being mixed thoroughly for 24 hours, row
Bubble obtains graphene-gelatin and carries liquid medicine gel out;
(3) preparation of graphene Traditional Chinese medicine gel packet: the graphene of step (2)-gelatin is carried into liquid medicine gel and is stirred evenly, mould is poured into
In tool, it is put into 0-4 DEG C of solidification sizing 24-48h of refrigerator, is fitted into the bonded ventilative woven fabric band of one side, graphene is made in sealing
Traditional Chinese medicine gel packet.
2. a kind of graphene lumbar medicinal waistband according to claim 1, which is characterized in that the graphene Traditional Chinese medicine gel packet
Content is prepared by following raw material: 15-30 parts of pueraria lobata, 10-15 parts of rhizoma curcumae longae concisa, 10-15 parts of the root of Chinese clematis, Rhizoma Chuanxiong
10-15 parts, 5-10 parts of gelatin, 0.01-1 parts of graphene.
3. a kind of graphene lumbar medicinal waistband according to claim 2, which is characterized in that the graphene Traditional Chinese medicine gel packet
Content is prepared by following raw material: 30 parts of pueraria lobata, 15 parts of rhizoma curcumae longae concisa, 15 parts of the root of Chinese clematis, 12 parts of Rhizoma Chuanxiong, gelatin 10
Part, 0.1 part of graphene.
4. a kind of graphene lumbar medicinal waistband according to claim 1, which is characterized in that the AB-8 resin can use NKA-
9, one of X-5, D-101, S-8, D16, D4020 are substituted.
5. a kind of graphene lumbar medicinal waistband according to claim 1, which is characterized in that concentration of alcohol is when the immersion
60%, concentration of alcohol is 50% when elution.
6. a kind of graphene lumbar medicinal waistband according to claim 1, which is characterized in that the Chinese medical extract aqueous solution
It is configured according to the weight ratio 1:50 of Chinese medical extract and water.
7. a kind of graphene lumbar medicinal waistband according to claim 1, which is characterized in that the graphene Traditional Chinese medicine gel packet
Detachably.
8. a kind of application method of graphene lumbar medicinal waistband described in a kind of -7 any claims according to claim 1,
It is characterized in that, the method follows the steps below:
(1) the graphene Traditional Chinese medicine gel packet being prepared into is adhered in the middle part of waistband internal layer splicing tape;
(2) it will be directed at afflicted area in the middle part of waistband internal layer, around one circle of waist winding, both ends are adhesively fixed.
9. a kind of graphene lumbar medicinal waistband described in a kind of -7 any claims according to claim 1 is for treating lumbar vertebrae pain
The application of pain.
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