CN109444441A - Automatic coagulation analyzer - Google Patents
Automatic coagulation analyzer Download PDFInfo
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- CN109444441A CN109444441A CN201811555204.6A CN201811555204A CN109444441A CN 109444441 A CN109444441 A CN 109444441A CN 201811555204 A CN201811555204 A CN 201811555204A CN 109444441 A CN109444441 A CN 109444441A
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- 230000015271 coagulation Effects 0.000 title claims abstract description 30
- 238000005345 coagulation Methods 0.000 title claims abstract description 30
- 238000001514 detection method Methods 0.000 claims abstract description 95
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 55
- 230000003287 optical effect Effects 0.000 claims abstract description 26
- 238000012360 testing method Methods 0.000 claims abstract description 24
- 238000005070 sampling Methods 0.000 claims abstract description 19
- 238000004140 cleaning Methods 0.000 claims description 37
- 239000007788 liquid Substances 0.000 claims description 37
- 230000007246 mechanism Effects 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 238000009434 installation Methods 0.000 claims description 18
- 239000012153 distilled water Substances 0.000 claims description 14
- 210000005239 tubule Anatomy 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 238000004821 distillation Methods 0.000 claims description 7
- 239000002699 waste material Substances 0.000 claims description 7
- 230000002572 peristaltic effect Effects 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000005057 refrigeration Methods 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 21
- 230000023555 blood coagulation Effects 0.000 abstract description 14
- 239000011521 glass Substances 0.000 description 17
- 238000010586 diagram Methods 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 230000005291 magnetic effect Effects 0.000 description 7
- 229910052782 aluminium Inorganic materials 0.000 description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 6
- 239000011324 bead Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 230000005298 paramagnetic effect Effects 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 230000007547 defect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229920006324 polyoxymethylene Polymers 0.000 description 3
- 230000000452 restraining effect Effects 0.000 description 3
- 206010053567 Coagulopathies Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000035602 clotting Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 206010019027 Haemothorax Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 230000003480 fibrinolytic effect Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of automatic coagulation analyzer, including it is open-topped be in box analyzer shell, be respectively arranged with sampling and delivery device, sample reagent disk device and detection module device in the analyzer shell；Sampling and delivery device includes crossbeam frame module, sample-adding cartridge module and sample needle；Sample reagent disk device and detection module device are arranged side by side in the front side of sampling and delivery device, and sample reagent disk device includes a rotatable sample reagent disk comprising three layers of upper, middle and lower, sample reagent disk is equipped with multiple reagent positions and sample bit；Detection module device includes detector cabinet and is set to the intracorporal detector of the detector bank.Automatic coagulation analyzer of the invention, the blood coagulation analyzer detect sample using optical method, while can improve the detection accuracy of Blood coagulation instrument, reduce testing cost.
Description
Technical field
The present invention relates to medical detection class equipment technical fields, and in particular to a kind of automatic coagulation analyzer.
Background technique
With the raising of medical technology, coagulation analysis has been analysis means conventional in hospital.Full automatic blood-coagulation analysis
The detection method of instrument is divided into two kinds: paramagnetic particle method and optical method.There is some defects, example mostly in blood coagulation analyzer currently on the market
As complicated for operation, high failure rate, accuracy is low, use cost is high, sense channel is less, detection speed it is unhappy, sample bit is less,
The defects of reagent position is less, is unable to remote service.
Paramagnetic particle method blood coagulation analyzer is using electric signal caused by the cutting in magnetic bead swing process to the magnetic line of force, to magnetic bead
Amplitude of fluctuation is monitored, and determines Coagulated hemothorax when magnetic bead amplitude of fluctuation decays to 50%.There are problems to be for this detection method:
Detection needs plus magnetic bead every time, complicated so as to cause detection detection method, testing cost is high, because magnetic bead quality it is difficult it is secure to
Test error is easily led to, and paramagnetic particle method is very high to detection wall of cup smoothness requirements.Therefore, the blood coagulation analyzer tool based on paramagnetic particle method
There is the defects of complicated for operation, high failure rate, accuracy are low, use cost is high.
Blood coagulation analyzer based on optical method is to measure coagulation function according to the variation of turbidity during the clotting of plasma,
It is easy to operate, detection is accurate, and because detection does not need to add magnetic bead, detects cost of labor and material cost is substantially better than paramagnetic particle method
Coagulo meter.Therefore optical method blood coagulation analyzer all has a clear superiority than paramagnetic particle method blood coagulation analyzer in all its bearings.
But since optical method has relatively high requirement to quality of hardware, how cause optical method technical threshold relatively high
Create a blood coagulation analyzer using optical detecting method, can improve Blood coagulation instrument detection accuracy, reduce testing cost and
The requirement that can lower to hardware becomes a problem in industry.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of automatic coagulation analyzer, which makes
Sample is detected with optical method, while the detection accuracy of Blood coagulation instrument can be improved, reduce testing cost.
In order to solve the above-mentioned technical problems, the present invention provides a kind of automatic coagulation analyzer, including it is open-topped
In box analyzer shell, sampling and delivery device, sample reagent disk device and inspection are respectively arranged in the analyzer shell
Survey modular device；
The sampling and delivery device includes that crossbeam frame module, sample-adding cartridge module and sample needle, the crossbeam frame module are fixed
In in the analyzer shell comprising cross beam frame and the first pulley mechanism being fixed on cross beam frame, first skin
Belt wheel mechanism is for driving sample-adding cartridge module to move back and forth in the horizontal direction；The sample-adding cartridge module include box body, sample arm and
It is set to intracorporal second pulley mechanism of box, offers vertical strip-shaped hole on front side of the box body, the one of the sample arm
End is extend into sample-adding box by the strip-shaped hole, and sample needle is fixedly connected on the other end；Second pulley mechanism is used for
Sample arm is driven to pump along the strip-shaped hole；
The sample reagent disk device and detection module device are arranged side by side in the front side of sampling and delivery device, the sample
Reagent tray device includes a rotatable sample reagent disk comprising three layers of upper, middle and lower, the sample reagent disk is equipped with multiple
Reagent position and sample bit；
The detection module device includes detector cabinet and is set to the intracorporal detector of the detector bank；It is described
Detector is fixed in detector box baseplate comprising bracket, the detection plate being arranged on the bracket and is set to institute
State the motor of frame bottom；The detection plate front offers multiple V-shaped grooves, be located in the detection plate adjacent two V-shaped groove it
Between position be provided with detection hole；Light emitting channel and light-receiving channel are respectively equipped on the two sides of the V-shaped groove, and adjacent
Light emitting channel and light-receiving channel on two V-shaped grooves are connected to a detection hole respectively；It is logical that pre-temperature is provided in the detection plate
Road, the detection plate side offer the through-hole for installing heating device, and the detection back is offered for installing temperature
Spend the blind hole of sensor；The detection back is provided with limit baffle, and limit optical coupled switch is provided on the bracket；It is described
The bracket for placing test glass is provided with above detector cabinet, the two sides of the bracket are mounted on detector cabinet two sides
Guide rod on, and by be set in front of the detector cabinet lead screw motor drive move forward and backward,；The lower section of the bracket
It is provided with limit baffle, the side of the detector cabinet is provided with limit optical coupled switch；The inside of the detector cabinet is set
Plastic box body is equipped with for closing detector space.
In a kind of preferred embodiment of the invention, the front side of the sample-adding box is located at strip-shaped hole and locates each affixed one up and down
Mounting plate is connected with vertical guide rod between the mounting plate, is connected on the guide rod in the middle part of the sample arm；Sample arm
Upper also projection is formed with the guide sleeve being set on the guide rod.
In a kind of preferred embodiment of the invention, the cross beam frame includes a pair of of mounting bracket and is fixedly connected on
Crossbeam between the mounting bracket, first pulley mechanism are set on the crossbeam；The crossbeam is equipped with deceleration position
Limit switch and zero-bit limit switch, the box body, which is equipped with, can trigger deceleration position limit switch and zero-bit limit switch
Limit baffle.
In a kind of preferred embodiment of the invention, it is equipped with level sensor in the sample needle, on the sample-adding box
Equipped with level detection box, the level detection circuit being electrically connected with the level sensor is equipped in the level detection box.
In a kind of preferred embodiment of the invention, the sample reagent disk device further includes heating module, described to add
Thermal modules include the heater strip for being wrapped in particular agent position and sample bit outer wall, and being sticked on the outside of the reagent position and sample bit has temperature
Spend sensor.
In a kind of preferred embodiment of the invention, the sample reagent disk device further includes refrigeration module, the system
Cold module includes the cooling piece being sticked below sample reagent disk second layer disk, and being sticked below the cooling piece has radiator,
Rear side, left side and the lower right of the sample reagent disk are provided with radiator fan.
It further include the sample needle cleaning system in analyzer shell in a kind of preferred embodiment of the invention,
The sample needle cleaning system includes cleaning liquid pipe, distillation water pipe, first choice valve, supervisor, the peristaltic pump on supervisor, the
Two selector valves, the first branch pipe, the second branch pipe, rinse bath, sewer pipe and the diaphragm pump on sewer pipe；
The cleaning liquid pipe, distillation water pipe and sewer pipe are stretched out from the multiple through-holes being set on analyzer shell, respectively
For connecting external cleaning solution bucket, Distilled water bucket and waste liquid barrel；The cleaning liquid pipe and distillation water pipe pass through first choice valve
It is connected to one end of supervisor, first branch pipe and the second branch pipe are connected to by the second selector valve with the other end of the supervisor；
The upper end of the sample needle is connected to the first branch pipe, and the rinse bath is connected to the second branch pipe；
Wherein, cleaning solution or distilled water enter sample needle through first branch pipe, to carry out to the inner wall of sample needle clear
It washes；Cleaning solution or distilled water enter rinse bath through second branch pipe, so that the outer wall to sample needle cleans.
In a kind of preferred embodiment of the invention, the rinse bath include an inner cylinder, an outer barrel, a tubule and
One cleaning slot cover；The inner cylinder is placed on the step of outer barrel inner wall, is in convex shape, and center is equipped with blind hole；The tubule
It is connected to across the outer cylinder body sidewall and with the side of the inner cylinder, second branch pipe and the tubule stretch out outer barrel
Part is connected to, and the sewer pipe is connected to the bottom of the outer barrel；The cleaning slot cover is covered in the outer barrel top,
Center is equipped with through-hole.
In a kind of preferred embodiment of the invention, batcher, the batcher packet are additionally provided on first branch pipe
The installation riser being fixed in analyzer shell is included, the side of the installation riser is fixed with precise quantitative device；The installation is vertical
A stepper motor is further fixed on plate, the stepper motor drives the piston rod of the precise quantitative device by gear and rack teeth mechanism
It pumps.
In a kind of preferred embodiment of the invention, vertical elongated hole, the step are offered in the installation riser
The other side of installation riser is set into motor and gear and rack teeth mechanism；Piston rod is fixed on the piston rod of the precise quantitative device
Bracket, the piston rod bracket pass through the elongated hole and are connected on the rack gear.
Beneficial effects of the present invention:
1, automatic coagulation analyzer of the invention is a kind of blood coagulation analyzer based on optical method, and it is solidifying to be able to detect blood
Gu system, anticoagulation system, fibrinolytic system, method is optics freezing method, immunization, Chromogenic assay respectively, is able to detect blood
More than 30 kinds of diseases of class, use scope are extensive.
2, automatic coagulation analyzer of the invention is easy to operate, high degree of automation, has multiple sense channels, and be
Independent sense channel is able to detect same or different project.
3, automatic coagulation analyzer of the invention can be conveniently realized in thrombotest and be taken to sample or reagent
Sample and sample-adding movement, have good walk precision and the speed of service, advantageously reduce detection error, improve detection accuracy.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of one embodiment of automatic coagulation analyzer of the invention；
Fig. 2 is the structural schematic diagram of sampling and delivery device in Fig. 1；
Fig. 3 is the top view of sampling and delivery device in Fig. 1；
Fig. 4 is the structural schematic diagram of sample reagent disk device in Fig. 1；
Fig. 5 is the structural schematic diagram of detection module device in Fig. 1；
Fig. 6 is the structural schematic diagram of the detector in Fig. 5；
Fig. 7 is the structural schematic diagram of sample needle cleaning system in automatic coagulation analyzer；
Fig. 8 is the structural schematic diagram of rinse bath in Fig. 7；
Fig. 9 is the structural schematic diagram of batcher in automatic coagulation analyzer；
Figure 10 is the side view of batcher in Fig. 9；
Figure label explanation:
100, analyzer shell；
200, sampling and delivery device；211, mounting bracket；212, crossbeam；213, linear guide；214, cross beam frame motor；
215, belt；216, belt pulley；217, deceleration position limit switch；218, zero-bit limit switch；219, sample arm limit switch；
220, box body；221, strip-shaped hole；222, baffle is limited；223, sample arm；224, guide sleeve；225, mounting plate；226, guide rod；
230, sample needle；240, level detection box；241, liquid level signal indicator light；
300, sample reagent disk device；310, sample reagent disk；311, first layer disk；312, second layer disk；313,
Third layer disk；321, sample bit；322, reagent position；323, reagent position can be heated；331, cooling piece；332, radiator；341,
Shaft；342, bearing；343 synchronizing belt gears；344, limit switch bracket；345, support construction；
400, detection module device；410, detector；411, detection plate；412, detection hole；413, V shape slot；414, light is sent out
Penetrate channel；415, light-receiving channel；416, pre-temperature hole；, 417, heating device mounting hole；418, temperature sensor fixing hole；
419, detector limits baffle；420, detector bracket；421, detector limit switch bracket；422, detector lead screw motor；
430, plastic box body；440, detector cabinet；441, bracket；442, test glass hole；443, guide rod；444, bracket lead screw motor；
445, bracket limits baffle；446, bracket limit switch bracket；
511, cleaning solution bucket；512, Distilled water bucket；513, waste liquid barrel；521, liquid pipe is cleaned；522, water pipe is distilled；523, main
Pipe；524, the first branch pipe；525, the second branch pipe；526, sewer pipe；531, first choice valve；532, the second selector valve；541, compacted
Dynamic pump；542, diaphragm pump；550, rinse bath；551, inner cylinder；552, outer barrel；553, tubule；554, blind hole；555, it drains
Mouthful；
610, installation riser；611, elongated hole；620, precise quantitative device；621, needle hub；622, piston rod；623, living
Stopper rod bracket；630, stepper motor；631, electric machine support；632, gear；633, rack gear；634, sliding rail；635, postive stop baffle；
636, optical coupled switch.
Specific embodiment
The present invention will be further explained below with reference to the attached drawings and specific examples, so that those skilled in the art can be with
It more fully understands the present invention and can be practiced, but illustrated embodiment is not as a limitation of the invention.
Shown in referring to Fig.1, an embodiment of automatic coagulation analyzer of the invention, including open-topped in box
Analyzer shell 100, the rear side of the analyzer shell 100 have acclivitous arcwall face, and being provided on arcwall face can turn over
Cover the transparent window opened.
Specifically, analyzer shell 100 is assembled by plastic components, including front panel, upper cover plate, left and right sides
Plate, support plate, lamina tecti and back shroud are mounted on sheet metal base plate and riser using fastener.Equipment rear has rectangle to open
Mouthful, interface board and metal plate cover board are installed.The rear lower right corner has 6 round holes, the pipeline and liquid level of sample needle cleaning system
Detection line is therefrom pierced by, and is divided into three groups of corresponding cleaning solution, distilled water and waste liquids；Device bottom is sheet metal base plate, and there are four lower sections
Feet, equipment are placed on level table when placing.
The upper left corner of front panel is panel leds, the instruction for instrument each limit switch and level detection state；It is right
Upper angle is three switch buttons and sample loading gun interface, and switch button respectively corresponds refrigeration, danger button, power supply.
Form facilitates operator to observe using dark-coloured transparent material, and has certain shaded effect；The left and right sides is vertical,
Top surface is horizontal, and front is inclined-plane, is integrated with top surface, is in certain radian；Front and back and side bottom edge are reinforced with frame；Form
It is connected using two hinge arrangements with instrument metal plate riser, hinge has damping, will not fall automatically when form is dug upwards
Under.
Sampling and delivery device 200, sample reagent disk device 300 and detection are respectively arranged in the analyzer shell 100
Modular device 400, wherein sample reagent disk device 300 and detection module device 400 are arranged side by side in sampling and delivery device 200
Front side.
Referring to figs. 2 and 3, sampling and delivery device 200 includes crossbeam frame module, sample-adding cartridge module and sample needle 230.Its
In, crossbeam frame module includes cross beam frame and the first pulley mechanism being fixed on cross beam frame, specifically, cross beam frame is in door
Type comprising the mounting bracket 211 and be fixedly connected between mounting bracket 211 that a pair is fixed in analyzer shell 100
Crossbeam 212, the first pulley mechanism are set on crossbeam 212, and a linear guide is also fixedly connected between mounting bracket 211
213.Preferably, mounting bracket 211 and crossbeam 212 are prepared by alumiaum article, can be played the role of absorbing vibration, be mentioned
Height walks precision.
Being loaded cartridge module includes box body 220, sample arm 223 and the second pulley mechanism being set in box body 220, box body
220 bottom is slidably connected in linear guide 213 by the bearing block in linear guide 213.The front side of box body 220 opens up
There is vertical strip-shaped hole 221, one end of sample arm 223 is extend into sample-adding box by the strip-shaped hole 221, fixed on the other end
Connect sample needle 230；Second pulley mechanism is for driving sample arm 223 to pump along strip-shaped hole 221.
In order to improve the precision of the up and down motion of sample needle 230, in the present embodiment, the front side of box body 220 is located at strip-shaped hole 221
Locate each affixed mounting plate 225 up and down, is connected with vertical guide rod 226 between mounting plate 225, the middle part of sample arm 223, which is worn, to be connect
In on guide rod 226, also projection is formed with the guide sleeve 224 being set on guide rod 226 on sample arm 223.
In the present embodiment, the first pulley mechanism is similar with the structure of the second pulley mechanism, is driven by belt pressing plate
Box body 220 and sample arm 223 move.Wherein, the first pulley mechanism is horizontally installed comprising cross beam frame motor 214, a pair
Belt pulley 216 and belt 215；Second pulley mechanism is vertically installed comprising sample-adding motor, a pair of of belt pulley 216 and skin
Band 215.
In order to improve the precision that walks, in the present embodiment, it is equipped with deceleration position limit switch 217 on crossbeam 212 and zero-bit limits
Bit switch 218, box body 220 are equipped with the limiting block that can trigger deceleration position limit switch 217 and zero-bit limit switch 218
Piece 222.When carrying out the absorption and filling of different location, the first pulley mechanism traction sample-adding cartridge module is along linear guide 213
Transverse movement, travel to and fro between each sample position, reagent position, check bit, between cleaning position.If the device starts after completing the movement of certain step
Zero-bit is returned, when passing through deceleration limit, limit baffle 222 triggers deceleration position slot optical coupling limit switch, and signal feedback is upper
Machine program, order motor reduce speed now；When reaching zero-bit limit, limit baffle 222 triggers zero-bit limit switch 218, signal
Feed back host computer procedure, order motor stop motion.
In addition, also being provided with limit baffle 222 on sample arm 223 in the present embodiment, corresponding position, which is equipped with, on box body 220 adds
Sample arm limit switch 219, to realize the stopping on vertical direction.
Sample needle 230 has needle-shaped pipeline structure, and top interface connects blood coagulation analyzer pipeline, and upper part has liquid level
Detector.It is loaded box and is equipped with level detection box 240, level detection circuit is equipped in level detection box 240, level sensor is logical
It crosses signal wire and connects the level detection circuit.Level detection circuit in the present embodiment is utilized using the principle of detection capacitor
When syringe needle touches the liquid in container, the circuit formed with liquid and container carries out liquid level judgement.When syringe needle touches liquid, obtain
To level detection plate feedback signal, liquid level has been touched in program judgement, and is issued instruction and carried out next step movement.Preferably, liquid level
It detects box 240 and is equipped with liquid level signal indicator light 241, the working condition of level detection function is judged convenient for user.
Referring to fig. 4, sample reagent disk device 300 is rotatably wrapped including one in the sample reagent disk 310 of disc structure
Include first layer disk 311, second layer disk 312 and third layer disk 313.It is provided with along the circumferential direction on sample reagent disk 310
Two kinds of hole locations of size, small hole location be sample bit 321, for placing the plasma sample of patient；Big hole location is reagent position 322, is used
In storage reagent container.
Sample bit 321 passes through second layer disk 312, is set between first layer disk 311 and third layer disk 313.Sample
The outer wall at one's own department or unit 321 is divided into two sections, and aluminium is respectively adopted in two sections and polyformaldehyde is made.It is wound with and adds on aluminum outer wall
Heated filament has swathed insulating layer to heat to sample on the outside of heater strip；The surface of aluminum outer wall is also sticked temperature sensing
Device.
Reagent position 322 is arranged between first layer disk 311 and second layer disk 312, is made of polyformaldehyde material.Examination
Tool is that can heat reagent position 323 there are two specific position in agent position 322, for storing the reagent container for needing to heat.Wherein,
It is three sections of upper, middle and lower that reagent position 323, which can be heated, to divide, and two sections are made of polyformaldehyde material, and middle section is aluminum.In aluminum outer wall
On be wound with heater strip to heat to reagent, insulating layer has been swathed on the outside of heater strip；The surface of aluminum outer wall is also sticked
Temperature sensor.
In addition, in the present embodiment, sample reagent disk device 300 further includes refrigerating plant, and refrigerating plant includes being attached at the
Cooling piece 331 below two layers of disk 312, the radiator 332 being sticked under cooling piece 331 and positioned at sample reagent disk 310
Three radiator fans in left side, rear and lower right.Wherein, positioned at left side and rear radiator fan wind direction towards radiator
332 to radiate to cooling fin；Round hole in the sheet metal base plate that the radiator fan of lower right is set to analyzer shell 100
On position, wind direction is downwards to be discharged analyzer shell 100 for air, to form convection current in inner space.
In addition, sample reagent disk 310 is arranged in the shaft 341 of reagent disk center in the present embodiment, shaft 341 is passed through
Two bearings 342 of close-fitting therewith, and it is installed on the support construction 345 for fixed sample reagent tray device 300, it supports
Structure 345 is fixed in the sheet metal base plate of analyzer shell 100.Motor and synchronizing belt gear 343 are additionally provided in shaft 341,
Motor drives synchronizing belt gear 343 by belt, and then sample reagent disk 310 is driven to rotate.It is also set up on synchronizing belt gear 343
There is discoidal code-disc, code-disc outer is provided with opening, can trigger the limit switch being arranged on limit switch bracket 344.
Referring to Fig. 5, detection module device 400 includes detector 410, and the detector 410 is formed with detector bracket 420
Movement mechanism, plastic box body 430 is provided with around the detector 410, and the detector 410 is installed in its external detection
On the bottom plate of device cabinet 440.
Specifically, detector cabinet 440 includes a bracket 441 that 440 top of detector cabinet is arranged in, support referring to Fig. 5
The test glass hole 442 of multiple lines and multiple rows is set on frame 441, for placing coagulation analysis detection test glass used.Pacify the two sides of bracket 441
On the guide rod 443 of 440 two sides of detector cabinet, bracket 441 is by being set to the bracket silk of the front side of detector cabinet 440
Bar motor 444 drives to carry out front-rear reciprocation movement.It is provided with bracket limit baffle 445 below bracket 441, is set to triggering
Limit switch on 440 side holder limit switch bracket 446 of detector cabinet.Modeling is additionally provided with inside detector cabinet 440
Body 430, for closing the space of installation detector 410, to reduce during clotting assay in detection module device 400
The heat in portion distributes and cross-ventilation, also acts as the effect for blocking foreign matter and dust.
Specifically, detector 410 includes a detection plate 411 referring to Fig. 6, multiple V are offered on the front of detection plate 411
Shape slot 413, the position in detection plate 411 between two V-shaped grooves 413 offer detection hole 412.On the two sides of V-shaped groove 413
It is respectively equipped with light emitting channel 414 and light-receiving channel 415, and light emitting channel 414 on adjacent two V-shaped groove 413 and light connect
Channel 415 is received to be connected to a detection hole 412 respectively.
In the present embodiment, it is additionally provided with the multiple pre-temperature holes 416 of a row in detection plate 411, is used for test glass pre-temperature, detection plate
411 sides offer heating device mounting hole 417 to install heating device, and detection plate offers temperature sensor on 411 back side
Mounting hole 418 is with mounting temperature sensor, for carrying out temperature control, to meet hemostasis examination temperature control requirement.Preferably,
The detection hole 412 and pre-temperature hole 416 are the blind round hole of bottom groove hemispherical, are conducive to the transmitting of optical signal and connect
It receives.
In the present embodiment, the detection plate 411 is mounted on detector bracket 420, and the bottom of detector bracket 420 is set
It is equipped with detector lead screw motor 422, to drive detection plate 411 to move up and down.411 front of detection plate is provided with detection
Device limits baffle 419, and for the limit optical coupled switch on detection trigger device limit switch bracket 421, the detector limit is opened
Bracket 421 is closed to be installed on detector bracket 420.
In the present embodiment, when coagulation analysis, which is tested, to be started, detection plate 411 is in bottom restraining position, host computer according to
The setting of operator judges to have in which test glass hole 442 available empty test glass, and bracket lead screw motor 442 instructs according to host computer
Specific pulse number is rotated, bracket 441 is driven to travel forward, until certain a line of bracket 441 lays the test glass hole of available test glass
442 are moved to the detection hole 412 of face below, and bracket lead screw motor 444 stops operating；It is then detected that device lead screw motor 422
Specific pulse number is rotated, drives detection plate 411 to move up to designated position, makes test glass bottom completely into detection hole 412；This
Light emission channel 414 and light-receiving channel 415 are directed at the side wall of the test glass, and the light that optical signal launch pipe is launched is by examination
The refraction or scattering of liquid, are received by optical signal reception pipe in cup sidewall and test glass；When sampling and delivery device 200 is completed finally to walk
After filling movement before rapid, according to the setting pre-heating time of operator and the test item carried out, to the liquid in test glass
Start pre-temperature；After the completion of pre-temperature, PC control detection circuit starts to track the signal that optical signal reception pipe receives；
After the completion of tracking, sampling and delivery device 200 completes final step filling movement, and detection circuit starts to continue to read the letter received
Number change and be transmitted to host computer, until reaction terminates in test glass；After reaction, detection plate 411 moves downwardly to zero-bit, i.e.,
Restraining position, detector limit baffle 419 and trigger optical coupled switch, and detector lead screw motor 422 stops operating；Then, bracket 441
Movement is returned to zero-bit, i.e. restraining position, and bracket limits baffle 445 and triggers optical coupled switch, and bracket lead screw motor 444 stops turning
It is dynamic；At this point, the coagulation analysis experiment that the test glass in the row detection hole 412 is carried out is completed.If still there is unfinished experiment, and on
When position machine judges still to have available test glass in next line detection hole 412, it will start to carry out the coagulation analysis experiment in next line test glass.
Referring to Fig. 7, sample needle cleaning system is additionally provided in analyzer shell 100 comprising cleaning liquid pipe 521, distilled water
Pipe 522, first choice valve 531, supervisor 523, the peristaltic pump 541 on supervisor 523, the second selector valve 532, the first branch pipe
524, the second branch pipe 525, rinse bath 550, sewer pipe 526 and the diaphragm pump 542 on sewer pipe 526.
Specifically, cleaning liquid pipe 521, distillation water pipe 522 and sewer pipe 526 stretch out the circle on analyzer shell respectively
Hole, for connecting external cleaning solution bucket 511, Distilled water bucket 512 and waste liquid barrel 513.
Cleaning liquid pipe 521 and the other end for distilling water pipe 522 are connected on supervisor 523 by first choice valve 531, are led to
Switching first choice valve 531 is crossed, that is, cleaning solution or distilled water may be selected to be cleaned.
The other end of supervisor 523 is connect with the first branch pipe 524 and the second branch pipe 525 respectively by the second selector valve 532,
Wherein, the end of the first branch pipe 524 is connect with sample needle 230, and the second branch pipe 525 is connect with rinse bath 550, sewer pipe 526
It is connected on rinse bath 550.Therefore, by switching the second selector valve 532, cleaning solution or distilled water enter through the first branch pipe 524
Sample needle 230 cleans the inner wall of sample needle 230；Or enter rinse bath 550 through the second branch pipe 525, to sample needle 230
Outer wall cleaned.
Referring to Fig. 8, in the present embodiment, rinse bath 550 includes an inner cylinder 551, an outer barrel 552, a tubule 553 and one
Clean slot cover (not shown).Inner cylinder 551 is placed on the step of 552 inner wall of outer barrel, is in convex shape, and center is equipped with blind hole
554.Tubule 553 passes through 552 side wall of outer barrel and is connected to the side of inner cylinder 551, and the second branch pipe 525 is stretched out with tubule 553
The part of outer barrel 552 is connected to, and sewer pipe 526 is connected to the discharge outlet 555 of the bottom of outer barrel 552.Cleaning slot cover is covered in
552 top of outer barrel, center are equipped with through-hole.
The cleaning process of sample needle cleaning system are as follows: first by the switch selection of first choice valve 531 for cleaning
Liquid, sample needle 230 rise；Then when the second selector valve 532 is opened, cleaning solution (or distilled water) is from the first branch pipe 524
Outflow is flowed into rinse bath 550 through sample needle 230, is cleaned to 230 inner wall of sample needle.Then, sample needle 230 declines,
Second selector valve 532 is closed, and peristaltic pump 541 is opened, and cleaning solution (or distilled water) is flowed out from the second branch pipe 525, by rinse bath
550 bottoms are gushed upwards, and sample needle 230 is inserted into rinse bath 550, are cleaned to 230 outer wall of sample needle；Inside and outside wall cleans same
When, diaphragm pump 542 works always, and waste liquid is retracted to waste liquid barrel 513 from rinse bath 550.
Referring to Fig. 9 and 10, be additionally provided with batcher 600 on the first branch pipe 524, can sampling amount to sample needle 230 into
Row is quantitative, to improve the accuracy of detection.The batcher 600 includes the installation riser 610 being fixed in analyzer shell 100,
The side of installation riser 610 is fixed with precise quantitative device 620, and a stepper motor 630, the stepper motor are fixed on the other side
630 drive the piston rod 622 of the precise quantitative device 620 to pump by gear and rack teeth mechanism.
Specifically, stepper motor 630 is fixed in installation riser 610 by electric machine support 631, it is fixed on the main shaft of motor
There is gear 632；Installation riser 610 is equipped with rack gear fixed plate, is fixed with sliding rail 634 in rack gear fixed plate, on the sliding rail 634
Rack gear 633 is slidably connected, and rack gear 633 is meshed with gear 632.The needle hub 621 of precise quantitative device 620 passes through pipeline
It is connected to sample needle 230, piston rod bracket 623 is fixed on the piston rod 622 of precise quantitative device 620, is opened in installation riser 610
Equipped with vertical elongated hole 611, the piston rod bracket 623 passes through elongated hole 611 and is fixedly connected on rack gear 633.
It in the present invention, is turned an angle by stepper motor 630, drives 632 turns of gear be fixed on electric machine main shaft
It is dynamic, gear 632 again band carry-over bar 633 vertically upward/move downward corresponding distance, to realize that piston rod 622 is forward/backward
Certain distance.Since the accuracy of rack-and-pinion is high, small step distance may be implemented, therefore the essence of sampling can be improved
Degree.In the present embodiment, the capacity of precise quantitative device 620 is 500 μ L, is divided into 5uL between minimum sample.
In the present embodiment, it is additionally provided with optical coupled switch 636 in installation riser 610, rack gear 633 is equipped with and can trigger optocoupler and open
Close 636 postive stop baffle 635.Optical coupled switch 636 is used to limit the extreme position of 620 piston rod 622 of precise quantitative device zero, when
After triggering optical coupled switch 636, stepper motor 630 receives signal and stops operating.
Batcher 600 realizes the course of work accurately sampled are as follows: when imbibition, stepper motor 630 is according to specified umber of pulse
Respective angles are rotated, the gear 632 on electric machine main shaft is with the corresponding distance of 633 vertical downward movement of carry-over bar；Piston rod 622 to
Lower movement, by the needle hub 621 of precise quantitative device 620, the liquid of respective volume is pressed into precise quantitative device by atmospheric pressure
620 inner cavities；Interface is connected with pipeline, while the sample of same volume or reagent are inhaled into pipeline；Liquid and original are sucked in pipeline
The air sucked in advance between liquid there are one section in this pipeline, it can be ensured that sucking liquid is not contaminated；When spitting liquid, stepper motor
630, with identical umber of pulse counter motion, drive piston rod 622 to move upwards same distance, and sucking liquid is spued；Zero
When, if piston rod 622 moves to zero position, postive stop baffle 635 triggers optical coupled switch 636, sends zero signal, stepper motor
630 receive signal stop motion.
Embodiment described above is only to absolutely prove preferred embodiment that is of the invention and being lifted, protection model of the invention
It encloses without being limited thereto.Those skilled in the art's made equivalent substitute or transformation on the basis of the present invention, in the present invention
Protection scope within.Protection scope of the present invention is subject to claims.
Claims (10)
1. a kind of automatic coagulation analyzer, which is characterized in that including it is open-topped be in box analyzer shell, described point
Sampling and delivery device, sample reagent disk device and detection module device are respectively arranged in analyzer shell；
The sampling and delivery device includes that crossbeam frame module, sample-adding cartridge module and sample needle, the crossbeam frame module are fixed on institute
It states in analyzer shell comprising cross beam frame and the first pulley mechanism being fixed on the cross beam frame, first skin
Belt wheel mechanism is for driving sample-adding cartridge module to move back and forth in the horizontal direction；The sample-adding cartridge module include box body, sample arm and
It is set to intracorporal second pulley mechanism of box, offers vertical strip-shaped hole on front side of the box body, the one of the sample arm
End is extend into sample-adding box by the strip-shaped hole, and the sample needle is fixedly connected on the other end；Second pulley mechanism
For driving sample arm to pump along the strip-shaped hole；
The sample reagent disk device and detection module device are arranged side by side in the front side of sampling and delivery device, the sample reagent
Disk device includes a rotatable sample reagent disk comprising three layers of upper, middle and lower, the sample reagent disk is equipped with multiple reagents
Position and sample bit；
The detection module device includes detector cabinet and is set to the intracorporal detector of the detector bank；The detection
Device is fixed in detector box baseplate comprising bracket, the detection plate being arranged on the bracket and is set to the branch
The motor of frame bottom；The detection plate front offers multiple V-shaped grooves, in the detection plate between adjacent two V-shaped groove
Position is provided with detection hole；Light emitting channel and light-receiving channel, and adjacent two V are respectively equipped on the two sides of the V-shaped groove
Light emitting channel and light-receiving channel on shape slot are connected to a detection hole respectively；Pre-temperature channel is provided in the detection plate,
The detection plate side offers the through-hole for installing heating device, and the detection back is offered to be passed for installing temperature
The blind hole of sensor；The detection back is provided with limit baffle, and limit optical coupled switch is provided on the bracket；The detection
The bracket for placing test cup is provided with above device cabinet, the two sides of the bracket are mounted on detector cabinet two sides
On guide rod, and moved forward and backward by being set to the lead screw motor drive in front of the detector cabinet；It is set below the bracket
It is equipped with limit baffle, the side of the detector cabinet is provided with limit optical coupled switch；The inside of the detector cabinet is arranged
There is plastic box body for closing detector space.
2. automatic coagulation analyzer as described in claim 1, which is characterized in that the front side of the sample-adding box is located at strip-shaped hole
Locate each affixed mounting plate up and down, is connected with vertical guide rod between the mounting plate, institute is connected in the middle part of the sample arm
It states on guide rod；Also projection is formed with the guide sleeve being set on the guide rod on sample arm.
3. automatic coagulation analyzer as described in claim 1, which is characterized in that the cross beam frame includes a pair of of mounting bracket
And it is fixedly connected on the crossbeam between the mounting bracket, first pulley mechanism is set on the crossbeam；The cross
Deceleration position limit switch and zero-bit limit switch are additionally provided on beam, the box body is opened equipped with that can trigger the deceleration position limit
Close the limit baffle with zero-bit limit switch.
4. automatic coagulation analyzer as described in claim 1, which is characterized in that be equipped with level detection in the sample needle
Device, the sample-adding box are equipped with level detection box, are equipped with the liquid being electrically connected with the level sensor in the level detection box
Position detection circuit.
5. automatic coagulation analyzer as described in claim 1, which is characterized in that the sample reagent disk device further includes adding
Thermal modules, the heating module include the heater strip for being wrapped in particular agent position and sample bit outer wall, the reagent position and sample
Position outside is sticked and has temperature sensor.
6. automatic coagulation analyzer as claimed in claim 5, which is characterized in that the sample reagent disk device further includes system
Cold module, the refrigeration module include the cooling piece being sticked below sample reagent disk second layer disk, below the cooling piece
Being sticked has radiator, and rear side, left side and the lower right of the sample reagent disk are provided with radiator fan.
7. automatic coagulation analyzer as described in claim 1, which is characterized in that further include adding in analyzer shell
Sample needle cleaning system, the sample needle cleaning system include cleaning liquid pipe, distillation water pipe, first choice valve, supervisor, are set to supervisor
On peristaltic pump, the second selector valve, the first branch pipe, the second branch pipe, rinse bath, sewer pipe and the diaphragm on sewer pipe
Pump；
The cleaning liquid pipe, distillation water pipe and sewer pipe are stretched out from three through-holes being set on analyzer shell, are respectively used to
Cleaning solution bucket, Distilled water bucket and waste liquid barrel outside connection；The cleaning liquid pipe and distillation water pipe pass through first choice valve and master
One end of pipe is connected to, and first branch pipe and the second branch pipe are connected to by the second selector valve with the other end of the supervisor；It is described
The upper end of sample needle is connected to the first branch pipe, and the rinse bath is connected to the second branch pipe；
Wherein, cleaning solution or distilled water enter sample needle through first branch pipe, so that the inner wall to sample needle cleans；Clearly
Washing lotion or distilled water enter rinse bath through second branch pipe, so that the outer wall to sample needle cleans.
8. automatic coagulation analyzer as claimed in claim 7, which is characterized in that the rinse bath includes an inner cylinder, one
Outer barrel, a tubule and a cleaning slot cover；The inner cylinder is placed on the step of outer barrel inner wall, is in convex shape, center is set
There is blind hole；The tubule is passed through and the outer cylinder body sidewall and is connected to the side of the inner cylinder, second branch pipe with it is described
Tubule stretches out the part connection of outer barrel, and the sewer pipe is connected to the bottom of the outer barrel；, the cleaning slot cover is covered in
The outer barrel top, center are equipped with through-hole.
9. automatic coagulation analyzer as claimed in claim 7, which is characterized in that be additionally provided on first branch pipe quantitative
Device, the batcher include the installation riser being fixed in analyzer shell, and the side of the installation riser is fixed with accurate fixed
Measuring device；A stepper motor is further fixed in the installation riser, the stepper motor drives the essence by gear and rack teeth mechanism
The piston rod of close batcher pumps.
10. automatic coagulation analyzer as claimed in claim 9, which is characterized in that it is vertical to offer in the installation riser
Elongated hole, the stepper motor and gear and rack teeth mechanism are set to the other side of installation riser；The piston of the precise quantitative device
Piston rod bracket is fixed on bar, the piston rod bracket passes through the elongated hole and is connected on the rack gear.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811555204.6A CN109444441A (en) | 2018-12-19 | 2018-12-19 | Automatic coagulation analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811555204.6A CN109444441A (en) | 2018-12-19 | 2018-12-19 | Automatic coagulation analyzer |
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| Publication Number | Publication Date |
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| CN109444441A true CN109444441A (en) | 2019-03-08 |
Family
ID=65560302
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811555204.6A Pending CN109444441A (en) | 2018-12-19 | 2018-12-19 | Automatic coagulation analyzer |
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Cited By (3)
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| CN112354575A (en) * | 2020-11-18 | 2021-02-12 | 珠海市康利莱医疗器械有限公司 | Production device and process suitable for heparin anticoagulant tube |
| CN112578523A (en) * | 2020-12-30 | 2021-03-30 | 中国科学院长春光学精密机械与物理研究所 | Optical filter switching device |
| CN116400086A (en) * | 2023-06-08 | 2023-07-07 | 北京众驰伟业科技发展有限公司 | Blood coagulation testing device |
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