CN109432209A - A kind of Chinese medicine calculus eliminating powder and preparation method thereof - Google Patents
A kind of Chinese medicine calculus eliminating powder and preparation method thereof Download PDFInfo
- Publication number
- CN109432209A CN109432209A CN201910055392.4A CN201910055392A CN109432209A CN 109432209 A CN109432209 A CN 109432209A CN 201910055392 A CN201910055392 A CN 201910055392A CN 109432209 A CN109432209 A CN 109432209A
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- parts
- chinese medicine
- stone
- seed
- powder
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- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
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- Chemical & Material Sciences (AREA)
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- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
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- Insects & Arthropods (AREA)
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- Cell Biology (AREA)
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- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
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Abstract
The invention discloses a kind of Chinese medicine calculus eliminating powders and preparation method thereof, belong to the field of Chinese medicines;Chinese medicine calculus eliminating powder includes the raw material of following parts by weight: 15-25 parts of herba lysimachiae, 10-15 parts of tangerine seed, 10-15 parts of walnut kernel, 7-13 parts of rock sugar, 3-7 parts of snake Huang, 5-15 parts of talcum, 10-20 parts of endothelium corneum gigeriae galli, 5-15 parts of Lygodium japonicum, 10-15 parts of chingma abutilon seed, 5-15 parts of humulus grass, 10-20 parts of Jinsha ox, 3-7 parts of realgar stone, 1-3 parts of Walnut Leaves, 8-12 parts of radish, loose 1-3 parts of cowherb, 10-20 parts of pangolin;Raw material of the present invention is naturally pollution-free, has no toxic side effect, to kidney stone, urethral calculus and gall stone have preferable therapeutic effect, are conducive to soften and be discharged calculus, greatly reduce disease incidence, the pain of patient is alleviated, and preparation process is simple, it is easy to accomplish industrialized production.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine calculus eliminating powder and preparation method thereof.
Background technique
Calculus is in human body or the intracorporal catheter lumen of animal or luminal organ (such as kidney, ureter, gall-bladder or bladder)
Chamber in the solid mass that is formed.It is mainly seen in gall-bladder and bladder, renal plevis, also seen in pancreas conduit, salivary ducts etc.
In chamber.Calculus is made of inorganic salts or organic matter.Generally have a core in calculus, by fall off epithelial cell, bacterial aggregate, post
Infested ovum or polypide, excrement block or foreign matter composition, inorganic salts or organic matter deposit on core layer by layer again.Not due to afflicted organ
Together, ingredient, shape contained by the mechanism of calculus, quality, influence to body etc. are all different.Generally speaking, calculus can
It causes lumen to block, influences the discharge of afflicted organ's liquid, generate the symptoms such as pain, bleeding or secondary infection.
Calculus mainly passes through operation or drug is treated, and treatment when performing the operation mainly for morbidity, patient endures larger
Pain, it is palliative, although drug therapy can soften calculus, reduce calculus generation, existing drug therapy
Effect is poor, needs to take for long periods of time, and have side effect, be not conducive to good health, it would still be possible to can generate calculus.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese medicine calculus eliminating powders and preparation method thereof, to solve to mention in above-mentioned background technique
Out the problem of.
To achieve the above object, the invention provides the following technical scheme:
A kind of Chinese medicine calculus eliminating powder, the raw material including following parts by weight: 15-25 parts of herba lysimachiae, 10-15 parts of tangerine seed, walnut kernel 10-
15 parts, 7-13 parts of rock sugar, 3-7 parts of snake Huang, 5-15 parts of talcum, 10-20 parts of endothelium corneum gigeriae galli, 5-15 parts of Lygodium japonicum, chingma abutilon seed 10-15
Part, 10-20 parts of Jinsha ox, 3-7 parts of realgar stone, 1-3 parts of Walnut Leaves, 8-12 parts of radish, loose 1-3 parts of cowherb, wears mountain at 5-15 parts of humulus grass
10-20 parts of first.
As a further solution of the present invention: the raw material including following parts by weight: 18-22 parts of herba lysimachiae, tangerine seed 11-13
Part, 11-13 parts of walnut kernel, 9-11 parts of rock sugar, 4-6 parts of snake Huang, 8-12 parts of talcum, 13-17 parts of endothelium corneum gigeriae galli, 7-13 parts of Lygodium japonicum,
10-14 parts of chingma abutilon seed, 8-12 parts of humulus grass, 13-17 parts of Jinsha ox, 4-6 parts of realgar stone, 1.5-2.5 parts of Walnut Leaves, radish 9-11
Part, loose 1.5-2.5 parts of cowherb, 14-16 parts of pangolin.
As a further solution of the present invention: the raw material including following parts by weight: 20 parts of herba lysimachiae, 12 parts of tangerine seed, core
12 parts of peach kernel, 10 parts of rock sugar, snake be 5 parts yellow, 10 parts of talcum, 15 parts of endothelium corneum gigeriae galli, 10 parts of Lygodium japonicum, 12 parts of chingma abutilon seed, 10 parts of humulus grass,
15 parts of Jinsha ox, 5 parts of realgar stone, 2 parts of Walnut Leaves, 10 parts of radish, loose 2 parts of cowherb, 15 parts of pangolin.
A kind of preparation method of Chinese medicine calculus eliminating powder, comprising the following steps:
(1) it is ground into after mixing walnut kernel, rock sugar, snake Huang, talcum, endothelium corneum gigeriae galli, Lygodium japonicum, Jinsha ox, realgar stone, pangolin
Fine powder is spare;
(2) ENDING CREDITS grass, tangerine seed, chingma abutilon seed, humulus grass, Walnut Leaves, radish, loose cowherb are extracted with steam distillation volatilize respectively
Oil, and by the volatile oil mixing for standby use after collection, by dregs of a decoction mixing for standby use;
(3) 4-6 times of water of its quality is added into the dregs of a decoction obtained by step (2), filtering retains filtrate after decoction;
(4) filtrate concentrated spray is dry, then fine powder and Mixed chaotic sequences are added, obtain Chinese medicine calculus eliminating powder after mixing evenly.
As a further solution of the present invention: fine powder partial size is 50-100 μm in the step (1).
As a further solution of the present invention: decocting time is 2-4h in the step (3).
As a further solution of the present invention: being filtered into 200 meshes in the step (3).
Herbal function used in the present invention is as follows:
Herba lysimachiae, be Ofthe Primulaceae Lysimachia christinae drying herb, alias christina loosestrife herb, to seat grass, roadside yellow, everywhere Huang,
Copper coin grass, a string of money;With removing dampness through diuresis and removing jaundice, inducing diuresis for treating strangurtia, the efficacy of removing toxicity for detumescence effect is usually used in jaundice with damp-heat pathogen, distension of gallbladder, hypochondriac pain, stone
Leaching, heat gonorrhea, difficulty and pain in micturition, carbuncle swells furunculosis, snakebite and bugbite.
Tangerine seed is the dry mature seed of rutaceae orange and its variety, alias orange benevolence, orange core, tangerine rice;
With qi-regulating, the effect of dissipating bind, analgesic, it to be used for hernia pain, testiclar gall, acute mastitis breast illness.
Walnut kernel is the seed of juglandaceae plant English walnut, has the effect of temperature compensation lung kidney, Dingchuan ease constipation, is used for kidney deficiency waist
Bitterly, foot is soft, the cold of insufficiency type is breathed with cough, dry feces.
Rock sugar decocts ice lump shaped crystalline made of refining for white sugar, has tonifying middle-Jiao and Qi, stomach function regulating moistening lung, and cough-relieving is coughed, resolving sputum saliva
The effect of.
Snake is yellow, i.e. the tuberculosis of oxide mineral limonite, has the effect of ﹑ hemostasis analgesic therapy is shied in the town An Shen.
Talcum, talcum are silicates talcum race mineral talc, and primary aqueous closes magnesium silicate, cures mainly damp-heat gonorrhoea, urine
It is unfavorable, drench puckery pain, oedema, tinea pedis, hot summer weather polydipsia, diarrhea eczema, wet sore, prickly heat.
Endothelium corneum gigeriae galli is the drying inner wall of sandbag of Phasianidae animal family chicken, alias chicken yellow skin, chicken feed skin, chicken crop;With stomach invigorating
It helps digestion, the effect of arresting seminal emission, treating stranguria fossil, is used for dyspepsia, vomiting dysentery, infantile malnutrition, the enuresis, spermatorrhea, urolithiasis is puckery
Bitterly, distension of gallbladder, hypochondriac pain.
Lygodium japonicum is the drying and ripening spore of Lygodiaceae plant Lygodium japonicum, alias Jinsha rattan, left-hand rotation rattan, bamboo plantation Sui, tool
There is the effect of eliminating dampness and heat, treating stranguria analgesic, is used for heat gonorrhea, urolithiasis, blood strangury, cream leaching, Urethra astringent pain.
Chingma abutilon seed is the fruit of malvaceae plant open country certain herbaceous plants with big flowers and winter certain herbaceous plants with big flowers, alias certain herbaceous plants with big flowers, certain herbaceous plants with big flowers vegetable seeds;With promoting diuresis for stranguria, laxation
The effect of defaecation, lower cream, it is usually used in stranguria syndrome, oedema, constipation, galactostasis.
The effect of humulus grass is the herb of moraceae plants humulus grass, has heat-clearing, and diuresis, disappear silt, removing toxic substances, it is small for controlling stranguria syndrome
Just unfavorable, malaria, diarrhea, dysentery, pulmonary tuberculosis, lung abscess, pneumonia, impetigo, hemorrhoid, carbuncle poison, scrofula.
Jinsha ox has the effect of antipyretic, antispastic, dissipating bind, inducing diuresis for treating strangurtia, change serious case of furuncle, is used for infantile hyperpyrexia, kidney and urethra
Calculus, difficult urination, scrofula, furunculosis.
Realgar stone is sulfide-based mineral realgar race realgar, main to contain realgar, alias realgar, red orpiment;With solution
The effect of poisoning worm, removing dampness and eliminating phlegm, preventing malaria, it is usually used in carbuncle swells furunculosis, snakebite and bugbite, abdominal pain due to enterositosis, frightened epilepsy, malaria.
Walnut Leaves are the leaf of juglandaceae plant English walnut, have removing toxic substances, the effect of detumescence, are used for elephant hide kind, leukorrhea,
Scabies.
Radish, it is cool in nature, hide Xin Gan, it is nontoxic, enter lung, stomach meridian, can remove food retention, in resolving sputum heat, lower gas, width, removing toxic substances, control dyspepsia
Turgor, phlegm are coughed aphonia, tuberculosis hemoptysis, vomiting sour regurgitation etc., can enhance body immunity, and can inhibit the growth of cancer cell, to anti-
Cancer, anticancer are significant.
Loose cowherb, alias pine mushroom, pine mushroom, shredded chicken bacterium, Trichotoma matsutake such as have beneficial intestines stomach invigorating, analgesic qi-regulating, keep fit and healthy at the function
Effect, stomach invigorating, diseases prevention, anticancer, control diabetes in terms of have the effect of auxiliary therapeutic action, also prevented presenility.
Pangolin, is the scale and shell of Manidae animal pangolin, and alias armadillo scale, first piece have cream under promoting menstruation, detumescence row
Purulence, is used for the mass amenorrhea due to blood stasis dredging, alactation, carbuncle sore tumefacting virus, arthralgia, numbness contracture the effect of searching wind and removing obstruction in channels.
Compared with prior art, it the beneficial effects of the present invention are: raw material is naturally pollution-free, has no toxic side effect, to kidney stone,
Urethral calculus and gall stone have preferable therapeutic effect, are conducive to soften and be discharged calculus, greatly reduce disease incidence, alleviate
The pain of patient, and preparation process is simple, it is easy to accomplish industrialized production.
Specific embodiment
The technical solution of the patent is explained in further detail With reference to embodiment.
Embodiment 1
A kind of Chinese medicine calculus eliminating powder, the raw material including following parts by weight: 15 parts of herba lysimachiae, 10 parts of tangerine seed, 10 parts of walnut kernel, rock sugar
7 parts, snake yellow 3 parts, 5 parts of talcum, 10 parts of endothelium corneum gigeriae galli, 5 parts of Lygodium japonicum, 10 parts of chingma abutilon seed, 5 parts of humulus grass, 10 parts of Jinsha ox, realgar stone
3 parts, 1 part of Walnut Leaves, 8 parts of radish, loose 1 part of cowherb, 10 parts of pangolin.
A kind of preparation method of Chinese medicine calculus eliminating powder, comprising the following steps:
(1) it is ground into after mixing walnut kernel, rock sugar, snake Huang, talcum, endothelium corneum gigeriae galli, Lygodium japonicum, Jinsha ox, realgar stone, pangolin
Partial size is that 50 μm of fine powder is spare;
(2) ENDING CREDITS grass, tangerine seed, chingma abutilon seed, humulus grass, Walnut Leaves, radish, loose cowherb are extracted with steam distillation volatilize respectively
Oil, and by the volatile oil mixing for standby use after collection, by dregs of a decoction mixing for standby use;
(3) water of 4 times of its quality is added into the dregs of a decoction obtained by step (2), crosses 200 meshes reservation filtrate after decocting 2h;
(4) filtrate concentrated spray is dry, then fine powder and Mixed chaotic sequences are added, obtain Chinese medicine calculus eliminating powder after mixing evenly.
Embodiment 2
A kind of Chinese medicine calculus eliminating powder, the raw material including following parts by weight: 18 parts of herba lysimachiae, 11 parts of tangerine seed, 11 parts of walnut kernel, rock sugar
9 parts, snake yellow 4 parts, 8 parts of talcum, 13 parts of endothelium corneum gigeriae galli, 7 parts of Lygodium japonicum, 10 parts of chingma abutilon seed, 8 parts of humulus grass, 13 parts of Jinsha ox, realgar stone
4 parts, 1.5 parts of Walnut Leaves, 9 parts of radish, loose 1.5 parts of cowherb, 14 parts of pangolin.
A kind of preparation method of Chinese medicine calculus eliminating powder, comprising the following steps:
(1) it is ground into after mixing walnut kernel, rock sugar, snake Huang, talcum, endothelium corneum gigeriae galli, Lygodium japonicum, Jinsha ox, realgar stone, pangolin
Partial size is that 62 μm of fine powder is spare;
(2) ENDING CREDITS grass, tangerine seed, chingma abutilon seed, humulus grass, Walnut Leaves, radish, loose cowherb are extracted with steam distillation volatilize respectively
Oil, and by the volatile oil mixing for standby use after collection, by dregs of a decoction mixing for standby use;
(3) water of 4.5 times of its quality is added into the dregs of a decoction obtained by step (2), crosses 200 meshes reservation filtrate after decocting 2.5h;
(4) filtrate concentrated spray is dry, then fine powder and Mixed chaotic sequences are added, obtain Chinese medicine calculus eliminating powder after mixing evenly.
Embodiment 3
A kind of Chinese medicine calculus eliminating powder, the raw material including following parts by weight: 20 parts of herba lysimachiae, 12 parts of tangerine seed, 12 parts of walnut kernel, rock sugar
10 parts, 5 parts of snake Huang, 10 parts of talcum, 15 parts of endothelium corneum gigeriae galli, 10 parts of Lygodium japonicum, 12 parts of chingma abutilon seed, 10 parts of humulus grass, 15 parts of Jinsha ox, hero
5 parts of Huangshi, 2 parts of Walnut Leaves, 10 parts of radish, loose 2 parts of cowherb, 15 parts of pangolin.
A kind of preparation method of Chinese medicine calculus eliminating powder, comprising the following steps:
(1) it is ground into after mixing walnut kernel, rock sugar, snake Huang, talcum, endothelium corneum gigeriae galli, Lygodium japonicum, Jinsha ox, realgar stone, pangolin
Partial size is that 75 μm of fine powder is spare;
(2) ENDING CREDITS grass, tangerine seed, chingma abutilon seed, humulus grass, Walnut Leaves, radish, loose cowherb are extracted with steam distillation volatilize respectively
Oil, and by the volatile oil mixing for standby use after collection, by dregs of a decoction mixing for standby use;
(3) 5 times of water of its quality are added into the dregs of a decoction obtained by step (2), cross 200 meshes reservation filtrate after decocting 3h;
(4) filtrate concentrated spray is dry, then fine powder and Mixed chaotic sequences are added, obtain Chinese medicine calculus eliminating powder after mixing evenly.
Embodiment 4
A kind of Chinese medicine calculus eliminating powder, the raw material including following parts by weight: 22 parts of herba lysimachiae, 13 parts of tangerine seed, 13 parts of walnut kernel, rock sugar
11 parts, 6 parts of snake Huang, 12 parts of talcum, 17 parts of endothelium corneum gigeriae galli, 13 parts of Lygodium japonicum, 14 parts of chingma abutilon seed, 12 parts of humulus grass, 17 parts of Jinsha ox, hero
6 parts of Huangshi, 2.5 parts of Walnut Leaves, 11 parts of radish, loose 2.5 parts of cowherb, 16 parts of pangolin.
A kind of preparation method of Chinese medicine calculus eliminating powder, comprising the following steps:
(1) it is ground into after mixing walnut kernel, rock sugar, snake Huang, talcum, endothelium corneum gigeriae galli, Lygodium japonicum, Jinsha ox, realgar stone, pangolin
Partial size is that 86 μm of fine powder is spare;
(2) ENDING CREDITS grass, tangerine seed, chingma abutilon seed, humulus grass, Walnut Leaves, radish, loose cowherb are extracted with steam distillation volatilize respectively
Oil, and by the volatile oil mixing for standby use after collection, by dregs of a decoction mixing for standby use;
(3) water of 5.5 times of its quality is added into the dregs of a decoction obtained by step (2), crosses 200 meshes reservation filtrate after decocting 3.5h;
(4) filtrate concentrated spray is dry, then fine powder and Mixed chaotic sequences are added, obtain Chinese medicine calculus eliminating powder after mixing evenly.
Embodiment 5
A kind of Chinese medicine calculus eliminating powder, the raw material including following parts by weight: 25 parts of herba lysimachiae, 15 parts of tangerine seed, 15 parts of walnut kernel, rock sugar
13 parts, 7 parts of snake Huang, 15 parts of talcum, 20 parts of endothelium corneum gigeriae galli, 15 parts of Lygodium japonicum, 15 parts of chingma abutilon seed, 15 parts of humulus grass, 20 parts of Jinsha ox, hero
7 parts of Huangshi, 3 parts of Walnut Leaves, 12 parts of radish, loose 3 parts of cowherb, 20 parts of pangolin.
A kind of preparation method of Chinese medicine calculus eliminating powder, comprising the following steps:
(1) it is ground into after mixing walnut kernel, rock sugar, snake Huang, talcum, endothelium corneum gigeriae galli, Lygodium japonicum, Jinsha ox, realgar stone, pangolin
Partial size is that 100 μm of fine powder is spare;
(2) ENDING CREDITS grass, tangerine seed, chingma abutilon seed, humulus grass, Walnut Leaves, radish, loose cowherb are extracted with steam distillation volatilize respectively
Oil, and by the volatile oil mixing for standby use after collection, by dregs of a decoction mixing for standby use;
(3) 6 times of water of its quality are added into the dregs of a decoction obtained by step (2), cross 200 meshes reservation filtrate after decocting 4h;
(4) filtrate concentrated spray is dry, then fine powder and Mixed chaotic sequences are added, obtain Chinese medicine calculus eliminating powder after mixing evenly.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (7)
1. a kind of Chinese medicine calculus eliminating powder, which is characterized in that the raw material including following parts by weight: 15-25 parts of herba lysimachiae, tangerine seed 10-
15 parts, 10-15 parts of walnut kernel, 7-13 parts of rock sugar, 3-7 parts of snake Huang, 5-15 parts of talcum, 10-20 parts of endothelium corneum gigeriae galli, Lygodium japonicum 5-15
Part, 10-15 parts of chingma abutilon seed, 5-15 parts of humulus grass, 10-20 parts of Jinsha ox, 3-7 parts of realgar stone, 1-3 parts of Walnut Leaves, 8-12 parts of radish,
Loose cowherb 1-3 parts, 10-20 parts of pangolin.
2. Chinese medicine calculus eliminating powder according to claim 1, which is characterized in that the raw material including following parts by weight: herba lysimachiae
18-22 parts, 11-13 parts of tangerine seed, 11-13 parts of walnut kernel, 9-11 parts of rock sugar, 4-6 parts of snake Huang, 8-12 parts of talcum, endothelium corneum gigeriae galli 13-17
Part, 7-13 parts of Lygodium japonicum, 10-14 parts of chingma abutilon seed, 8-12 parts of humulus grass, 13-17 parts of Jinsha ox, 4-6 parts of realgar stone, Walnut Leaves 1.5-
2.5 parts, 9-11 parts of radish, loose 1.5-2.5 parts of cowherb, 14-16 parts of pangolin.
3. Chinese medicine calculus eliminating powder according to claim 1, which is characterized in that the raw material including following parts by weight: herba lysimachiae
20 parts, 12 parts of tangerine seed, 12 parts of walnut kernel, 10 parts of rock sugar, snake yellow 5 parts, 10 parts of talcum, 15 parts of endothelium corneum gigeriae galli, 10 parts of Lygodium japonicum, winter certain herbaceous plants with big flowers
12 parts of son, 10 parts of humulus grass, 15 parts of Jinsha ox, 5 parts of realgar stone, 2 parts of Walnut Leaves, 10 parts of radish, loose 2 parts of cowherb, 15 parts of pangolin.
4. a kind of preparation method of Chinese medicine calculus eliminating powder a method according to any one of claims 1-3, which is characterized in that including following step
It is rapid:
It is ground into after walnut kernel, rock sugar, snake Huang, talcum, endothelium corneum gigeriae galli, Lygodium japonicum, Jinsha ox, realgar stone, pangolin are mixed thin
Powder is spare;
ENDING CREDITS grass, tangerine seed, chingma abutilon seed, humulus grass, Walnut Leaves, radish, loose cowherb are extracted into volatile oil respectively with steam distillation,
And by the volatile oil mixing for standby use after collection, by dregs of a decoction mixing for standby use;
4-6 times of water of its quality is added into the dregs of a decoction obtained by step (2), filtering retains filtrate after decoction;
Filtrate concentrated spray is dry, then fine powder and Mixed chaotic sequences are added, obtain Chinese medicine calculus eliminating powder after mixing evenly.
5. the preparation method of Chinese medicine calculus eliminating powder as claimed in claim 4, which is characterized in that fine powder partial size in the step (1)
It is 50-100 μm.
6. the preparation method of Chinese medicine calculus eliminating powder as claimed in claim 4, which is characterized in that decocting time in the step (3)
For 2-4h.
7. the preparation method of Chinese medicine calculus eliminating powder as claimed in claim 4, which is characterized in that be filtered into the step (3)
200 meshes.
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