CN109432163A - A kind of compound durian peel ointment and preparation method thereof - Google Patents
A kind of compound durian peel ointment and preparation method thereof Download PDFInfo
- Publication number
- CN109432163A CN109432163A CN201910010761.8A CN201910010761A CN109432163A CN 109432163 A CN109432163 A CN 109432163A CN 201910010761 A CN201910010761 A CN 201910010761A CN 109432163 A CN109432163 A CN 109432163A
- Authority
- CN
- China
- Prior art keywords
- parts
- mixture
- filtrate
- mixed
- durian peel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of compound durian peel ointment and preparation method thereof, compound durian peel ointment includes the raw material of following parts by weight: 100~200 parts of durian peel stoste, 55~95 parts of purslane Radix Glycyrrhizae mixture, 1800~2200 parts of albolene, 400~500 parts of atoleine, 30~50 parts of lanolin, 15~25 parts of Tween 80 and 16~28 parts of triethanolamine.Effect that compound durian peel ointment of the invention has clearing heat and moistening dryness antipruritic, can effectively treat atopic dermatitis, without side-effects, safety is good, and its preparation process is simple, at low cost.
Description
Technical field
The present invention relates to pharmaceutical technology fields more particularly to a kind of compound durian peel ointment and preparation method thereof.
Background technique
Atopic dermatitis (Atopic Dermatitis, AD) is a kind of chronic, recurrent and inflammatory dermatoses, mainly
It is related with the internal and external factors such as hereditary, immune, skin barrier function, infection, environment and Psychomotor test Battrey.Childhood that this disease is mainly in,
Usually recurrent exerbation, touching refractory, brings adverse effect to the body and mind of infant, and it is aobvious to find rationally effective therapeutic scheme as early as possible
It obtains extremely urgent.Western medical treatment mainly adjusts immune, skin-moisturizing, skin and antipruritic, long-term external application sugar cortical hormone by drug at present
The drugs such as element, anti-inflammatory agent and antipruritic have many adverse reactions, and there are rebound phenomenons after drug withdrawal, and this disease is often with trouble
Youngster's entire growth stage, the course of disease are up to ten or twenty year, greatly limit the long-time service of Western medicine.
The pathogenesis of atopic dermatitis is complex, is not fully apparent from also at present, in recent years every clinical studies show
Skin barrier function is the major reason that AD occurs extremely, therefore restores skin barrier function as intervention AD occurrence and development
Important measures, and water content of stratum corneum, pH value and transepidermal water loss amount (TEWL) they are the important of composition skin barrier function
Factor.Studies have shown that the situation of AD infant skin barrier function exception is more universal compared with healthy children, cutin is shown as
Damage layer, the decline of skin moisture-keeping ability, cutaneous lesion adjusts the ability decline of soda acid buffering, so that keratoderma water content
Decline, pH value and TEWL value increase.
Summary of the invention
The technical problems to be solved by the present invention are: a kind of compound durian peel ointment and preparation method thereof is provided, it can be effective
Treat atopic dermatitis.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention are as follows:
A kind of compound durian peel ointment, the raw material including following parts by weight: 100~200 parts of durian peel stoste, purslane are sweet
55~95 parts of careless mixture, 1800~2200 parts of albolene, 400~500 parts of atoleine, 30~50 parts of lanolin, tween
80 15~25 parts and 16~28 parts of triethanolamine.
Another technical solution that the present invention uses are as follows:
The preparation method of compound durian peel ointment, by durian peel stoste, purslane Radix Glycyrrhizae mixture, Tween 80 and three ethyl alcohol
Amine is mixed, and the first mixture is obtained;First mixture is heated to 28~32 DEG C, then to first mixture
Middle addition atoleine, obtains the second mixture, and second mixture is first heated to 75~85 DEG C, it is subsequently cooled to 38~
42℃;Albolene and lanolin are mixed, third mixture is obtained, the third mixture is first heated to 75~85
DEG C, it is subsequently cooled to 38~42 DEG C;38~42 DEG C of the second mixture is mixed with 38~42 DEG C of third mixture, is obtained
To the compound durian peel ointment.
The beneficial effects of the present invention are: durian peel stoste has Runzao Zhiyang and anti-inflammatory effect, and purslane Radix Glycyrrhizae is mixed
Closing object has effects that clearing heat and detoxicating and anti-inflammatory anti-itch;Albolene prevents moisture of skin as ointment bases, Castor Oil moisturizing
It loses;Atoleine is as ointment bases, Castor Oil moisturizing;Lanolin has the function of moistening and soften, and can promote drug quilt
Mucous membrane and skin absorb;Tween 80, triethanolamine can thicken moisturizing, improve the stability of ointment as emulsifier.Of the invention
Effect that compound durian peel ointment has clearing heat and moistening dryness antipruritic, can effectively treat atopic dermatitis, and without side-effects, safety is good,
And its preparation process is simple, it is at low cost.
Specific embodiment
To explain the technical content, the achieved purpose and the effect of the present invention in detail, it is explained below in conjunction with embodiment.
The most critical design of the present invention is: by durian peel stoste, purslane Radix Glycyrrhizae mixture and albolene, liquid stone
Wax, lanolin, Tween 80 and triethanolamine are compounded, and obtained ointment can effectively treat atopic dermatitis.
A kind of compound durian peel ointment, the raw material including following parts by weight: 100~200 parts of durian peel stoste, purslane are sweet
55~95 parts of careless mixture, 1800~2200 parts of albolene, 400~500 parts of atoleine, 30~50 parts of lanolin, tween
80 15~25 parts and 16~28 parts of triethanolamine.
As can be seen from the above description, the beneficial effects of the present invention are: durian peel stoste has Runzao Zhiyang and anti-inflammatory function
Effect, purslane Radix Glycyrrhizae mixture have effects that clearing heat and detoxicating and anti-inflammatory anti-itch;Albolene is protected as ointment bases, Castor Oil
It is wet, prevent moisture of skin from losing;Atoleine is as ointment bases, Castor Oil moisturizing;Lanolin has the work for moistening and softening
With can promote drug and absorbed by mucous membrane and skin;Tween 80, triethanolamine can thicken moisturizing, improve ointment as emulsifier
Stability.Effect that compound durian peel ointment of the invention has clearing heat and moistening dryness antipruritic, can effectively treat atopic dermatitis, no pair
Effect, safety is good,.
Further, the raw material including following parts by weight: 150 parts of durian peel stoste, 75 parts of purslane Radix Glycyrrhizae mixture, white
2000 parts of vaseline, 450 parts of atoleine, 40 parts of lanolin, 20 parts of Tween 80 and 22 parts of triethanolamine.
Another technical solution of the present invention are as follows:
The preparation method of compound durian peel ointment, by durian peel stoste, purslane Radix Glycyrrhizae mixture, Tween 80 and three ethyl alcohol
Amine is mixed, and the first mixture is obtained;First mixture is heated to 28~32 DEG C, then to first mixture
Middle addition atoleine, obtains the second mixture, and second mixture is first heated to 75~85 DEG C, it is subsequently cooled to 38~
42℃;Albolene and lanolin are mixed, third mixture is obtained, the third mixture is first heated to 75~85
DEG C, it is subsequently cooled to 38~42 DEG C;38~42 DEG C of the second mixture is mixed with 38~42 DEG C of third mixture, is obtained
To the compound durian peel ointment.
Seen from the above description, the preparation process of compound durian peel ointment is simple, at low cost.
Further, durian peel is mixed with water, decocts 1~3h, then isolated first filtrate and the first filter residue;It will
First filter residue is mixed with water, continues 1~3h of decoction, then isolated second filtrate;By first filtrate and second
Filtrate is mixed, and the first mixed filtrate is obtained, and first mixed filtrate is concentrated, and obtains the durian peel stoste,
The density of the durian peel stoste is 1.25~1.3g/cm3。
Further, purslane, Radix Glycyrrhizae and water are mixed, decocts 1~3h, then isolated third filtrate and third filter
Slag;The third filter residue is mixed with water, continues 1~3h of decoction, then isolated 4th filtrate;By the third filtrate and
4th filtrate is mixed, and the second mixed filtrate is obtained, and second mixed filtrate is concentrated, it is sweet to obtain the purslane
Careless mixture, the density of the purslane Radix Glycyrrhizae mixture are 1.25~1.3g/cm3。
Embodiment one
The embodiment of the present invention one is a kind of preparation method of compound durian peel ointment, is included the following steps:
1, the preparation of durian peel stoste
Durian peel is mixed with water, decocts 1~3h, then isolated first filtrate and the first filter residue;By described first
Filter residue is mixed with water, continues 1~3h of decoction, then isolated second filtrate;First filtrate and the second filtrate are carried out
Mixing, obtains the first mixed filtrate, first mixed filtrate is concentrated, and obtains durian peel stoste, and the durian peel is former
The density of liquid is 1.25~1.3g/cm3.The dosage of durian peel and water, which can according to need, to be selected, under normal circumstances, water
Dosage is 5~6 times of durian peel.
2, the preparation of purslane Radix Glycyrrhizae mixture
Purslane, Radix Glycyrrhizae and water are mixed, decoct 1~3h, then isolated third filtrate and third filter residue;It will be described
Third filter residue is mixed with water, continues 1~3h of decoction, then isolated 4th filtrate;By the third filtrate and the 4th filtrate
It is mixed, obtains the second mixed filtrate, second mixed filtrate is concentrated, obtain purslane Radix Glycyrrhizae mixture, institute
The density for stating purslane Radix Glycyrrhizae mixture is 1.25~1.3g/cm3.The specific dosage of purslane, Radix Glycyrrhizae and water can be according to need
It is selected, in the present embodiment, the dosage of purslane is twice of Radix Glycyrrhizae, and the dosage of water is purslane and Radix Glycyrrhizae total weight
5~6 times.
3, the preparation of compound durian peel ointment
By purslane Radix Glycyrrhizae mixture, 15~25 weights of the durian peel stoste of 100~200 parts by weight, 55~95 parts by weight
The triethanolamine of the Tween 80 and 16~28 parts by weight of measuring part is mixed, and the first mixture is obtained;By first mixture
28~32 DEG C are heated to, the atoleine of 400~500 parts by weight is then added into first mixture, it is mixed to obtain second
Object is closed, second mixture is first heated to 75~85 DEG C, is subsequently cooled to 38~42 DEG C;By 1800~2200 parts by weight
Albolene and the lanolin of 30~50 parts by weight are mixed, and third mixture is obtained, and the third mixture is first heated
To 75~85 DEG C, it is subsequently cooled to 38~42 DEG C;By 38~42 DEG C of the second mixture and 38~42 DEG C of third mixture into
Row mixing obtains compound durian peel ointment, and after cooling, compound durian peel ointment is the paste of sepia.
Embodiment two
The embodiment of the present invention two is a kind of preparation method of compound durian peel ointment, is existed with the difference of embodiment one
In:
1, the preparation of durian peel stoste
Durian peel is mixed with water, decocts 2h, then isolated first filtrate and the first filter residue;By first filter residue
It is mixed with water, continues to decoct 2h, then isolated second filtrate;First filtrate and the second filtrate are mixed, obtained
To the first mixed filtrate, first mixed filtrate is concentrated, durian peel stoste is obtained.
2, the preparation of purslane Radix Glycyrrhizae mixture
Purslane, Radix Glycyrrhizae and water are mixed, decoct 2h, then isolated third filtrate and third filter residue;By described
Three filter residues are mixed with water, continue to decoct 2h, then isolated 4th filtrate;The third filtrate and the 4th filtrate are mixed
It closes, obtains the second mixed filtrate, second mixed filtrate is concentrated, obtain purslane Radix Glycyrrhizae mixture.
3, the preparation of compound durian peel ointment
By the durian peel stoste of 150 parts by weight, the purslane Radix Glycyrrhizae mixture of 75 parts by weight, 20 parts by weight Tween 80 and
The triethanolamine of 22 parts by weight is mixed, and the first mixture is obtained;First mixture is heated to 30 DEG C, then to institute
The atoleine that 450 parts by weight are added in the first mixture is stated, the second mixture is obtained, second mixture is first heated to
80 DEG C, it is subsequently cooled to 40 DEG C;The lanolin of the albolene of 2000 parts by weight and 40 parts by weight is mixed, third is obtained
The third mixture is first heated to 80 DEG C, is subsequently cooled to 40 DEG C by mixture;By 40 DEG C of the second mixture and 40 DEG C
Third mixture is mixed, and the compound durian peel ointment is obtained.
Embodiment three
The embodiment of the present invention three is a kind of preparation method of compound durian peel ointment, is existed with the difference of embodiment one
In:
1, the preparation of durian peel stoste
Durian peel is mixed with water, decocts 3h, then isolated first filtrate and the first filter residue;By first filter residue
It is mixed with water, continues to decoct 1h, then isolated second filtrate;First filtrate and the second filtrate are mixed, obtained
To the first mixed filtrate, first mixed filtrate is concentrated, durian peel stoste is obtained.
2, the preparation of purslane Radix Glycyrrhizae mixture
Purslane, Radix Glycyrrhizae and water are mixed, decoct 3h, then isolated third filtrate and third filter residue;By described
Three filter residues are mixed with water, continue to decoct 1h, then isolated 4th filtrate;The third filtrate and the 4th filtrate are mixed
It closes, obtains the second mixed filtrate, second mixed filtrate is concentrated, obtain purslane Radix Glycyrrhizae mixture.
3, the preparation of compound durian peel ointment
By the durian peel stoste of 100 parts by weight, the purslane Radix Glycyrrhizae mixture of 95 parts by weight, 25 parts by weight Tween 80 and
The triethanolamine of 16 parts by weight is mixed, and the first mixture is obtained;First mixture is heated to 28 DEG C, then to institute
The atoleine that 500 parts by weight are added in the first mixture is stated, the second mixture is obtained, second mixture is first heated to
85 DEG C, it is subsequently cooled to 42 DEG C;The lanolin of the albolene of 2200 parts by weight and 30 parts by weight is mixed, third is obtained
The third mixture is first heated to 85 DEG C, is subsequently cooled to 42 DEG C by mixture;By 42 DEG C of the second mixture and 42 DEG C
Third mixture is mixed, and the compound durian peel ointment is obtained.
Example IV
The embodiment of the present invention four is a kind of preparation method of compound durian peel ointment, is existed with the difference of embodiment one
In:
1, the preparation of durian peel stoste
Durian peel is mixed with water, decocts 1h, then isolated first filtrate and the first filter residue;By first filter residue
It is mixed with water, continues to decoct 3h, then isolated second filtrate;First filtrate and the second filtrate are mixed, obtained
To the first mixed filtrate, first mixed filtrate is concentrated, durian peel stoste is obtained.
2, the preparation of purslane Radix Glycyrrhizae mixture
Purslane, Radix Glycyrrhizae and water are mixed, decoct 1h, then isolated third filtrate and third filter residue;By described
Three filter residues are mixed with water, continue to decoct 3h, then isolated 4th filtrate;The third filtrate and the 4th filtrate are mixed
It closes, obtains the second mixed filtrate, second mixed filtrate is concentrated, obtain purslane Radix Glycyrrhizae mixture.
3, the preparation of compound durian peel ointment
By the durian peel stoste of 200 parts by weight, the purslane Radix Glycyrrhizae mixture of 75 parts by weight, 15 parts by weight Tween 80 and
The triethanolamine of 28 parts by weight is mixed, and the first mixture is obtained;First mixture is heated to 32 DEG C, then to institute
The atoleine that 400 parts by weight are added in the first mixture is stated, the second mixture is obtained, second mixture is first heated to
75 DEG C, it is subsequently cooled to 38 DEG C;The lanolin of the albolene of 1800 parts by weight and 50 parts by weight is mixed, third is obtained
The third mixture is first heated to 75 DEG C, is subsequently cooled to 38 DEG C by mixture;By 38 DEG C of the second mixture and 38 DEG C
Third mixture is mixed, and the compound durian peel ointment is obtained.
Measure of merit
Measure of merit is carried out to the compound durian peel ointment (by taking embodiment two as an example) that the present invention is prepared, it is specific to test
Process is as follows:
1, the selection of experimental subjects
120 patients are selected, are institute of traditional Chinese medicine, Shenzhen Dermatology Outpatient Department patient, are divided into two groups according to single blind, randomized.
Treatment group's (compound durian peel ointment group) patient's minimal ages 12 years old, max age 49 years old, average age 20.53 ± 7.80;Most
The short course of disease 2 years, the longest course of disease 28 years, average course of disease 10.83 ± 5.53 years;Wherein male 37, women 23.Control group (chaff
Sour Mometasone group) minimal ages 13 years old, max age 48 years old, average age 22.83 ± 7.61;The most short course of disease 1 year, the longest course of disease
27 years, average course of disease 12.17 ± 6.74 years;Wherein male 31, women 29.It is general to compare two groups of genders, age, courses of disease etc.
Data, no significant difference (P > 0.05), is comparable.
2, diagnostic criteria
Western medicine diagnostic criteria formulated the Williams diagnosis mark delivered with reference to Britain's atopic dermatitis cooperative groups 1994
It is quasi-.
3, it is included in standard
(1) meet Western medicine diagnostic criteria and exclusion criteria;(2) age limit was at -49 years old 12 years old;(3) at least one moon not
Through any treatment.
4, exclusion criteria
(1) gestation or breast feeding women;(2) other skin diseases of atopic dermatitis or pigment are heavy except treatment region has
, the skin lesions such as scar;(3) skin lesion is with infection when treatment starts;(4) to ingredient any in the ointment person that has allergic phenomena;
(5) merge other internal diseases person;(6) person that is reluctant partner treatment.
5, experimental method
120 patients are randomly divided into two groups, every group of 60 people wipe compound durian peel ointment outside treatment group, 2 times a day, early
Evening each 1 time.0.1% Momestasone furoate cream is wiped outside control group, 2 times a day, each 1 time sooner or later.Two groups equal continuous use 28 days.
Observation experiment person was in the 0th, 2,4 week skin lesion severity (erythema, oedema/infiltration/papule, the scales of skin that peel off, moss sample respectively
Become by without, it is light, in, be again respectively 0,1,2,3 point of scoring), itch degree (by without, it is light, in, again score).The skin being grievously injured journey
Degree uses visual analogue scale point system using atopic dermatitis Scoring Index SCORAD scoring general in the world, itch
(VAS)。
Keratoderma water content, skin ph, transepidermal water loss amount are measured respectively within the 0th, 2,4 week in experiment
(TEWL) skin barrier function is evaluated.Measuring instrument: the measurement of water content of stratum corneum and skin ph uses skin oil and fat water
Alkalinity acidity tester (Courage Khazaka, Germany) is divided to measure, transepidermal water loss amount uses moisture of skin
Tester TM300 (Courage Khazaka, Germany) is lost to measure.
6, safety observations
Adverse reaction: patient is observed in therapeutic process using skin after drug and skin lesion flush, itch exacerbation etc. whether occurs
Symptom, and patient medication is advised to report researcher at any time if any discomfort in the process.
Processing method: if adverse reaction occurs in subject, its time of immediate record, position, sings and symptoms are answered, and assess
Whether need to be handled, is not suitable for continuing medication in case of exceptional circumstances, should stop to test.
7, statistical method
Using SPSS18.0 statistical software, after homogeneity test of variance, enumeration data uses Chi-square Test, and measurement data is adopted
It is examined with t.Level of significance α=0.05, it is statistically significant with P < 0.05.
8, result
SCORAD scoring is more as shown in table 1.
1 SCORAD of table scoring comparison result
Time | Treatment group | Control group | t | P |
0th week | 51.07±8.87 | 52.03±7.16 | 0.651 | 0.270 |
2nd week | 43.96±5.42 | 46.68±6.17 | 2.2555 | 0.118 |
4th week | 39.58±4.80 | 43.39±3.70 | 4.868 | 0.043 |
As known from Table 1, treatment starts preceding two groups of SCORAD scoring no significant difference (P > 0.05), is comparable.Treatment
The 2nd week afterwards, two groups of still no significant differences, but treatment group's downward trend is better than control group;The 4th week after treatment, compare two groups
SCORAD scoring has notable difference (P < 0.05), shows compound durian peel ointment late result better than control group.
VAS scoring comparison result is as shown in table 2.
2 VAS of table scoring comparison result
As known from Table 2, treatment starts preceding two groups of VAS scoring no significant difference (P > 0.05), is comparable.After treatment
2 weeks, two groups of still no significant differences, but treatment group's downward trend is better than control group;The 4th week after treatment, compare two groups of VAS scoring tools
There is notable difference (P < 0.05), shows that compound durian peel ointment, which is used for a long time, can be effectively improved pruritis, improve minimal invasive treatment
Quality.
The comparison result of water content of stratum corneum is as shown in table 3 at skin lesion.
The comparison result of 3 water content of stratum corneum of table
Treatment time | Treatment group | Control group | t | P |
0th week | 27.11±5.02 | 26.02±6.24 | 1.048 | 0.351 |
2nd week | 33.25±2.96 | 29.27±4.44 | 5.774 | 0.017 |
4th week | 42.11±3.61 | 35.99±2.46 | 10.848 | 0.038 |
As known from Table 3, treatment starts preceding two groups of water content of stratum corneum no significant differences (P > 0.05), is comparable.It controls
The 2nd week after treatment, two groups of water content of stratum corneum have notable difference (P < 0.05);The 4th week after treatment, treatment group's water content of stratum corneum
It is substantially better than control group, the two difference is obvious, shows that externally used compound durian peel ointment can significantly improve water content of stratum corneum, this is right
Have in recovery skin barrier function extremely important.
The comparison result of pH value is as shown in table 4 at skin lesion.
The comparison of pH value at 4 skin lesion of table
Treatment time | Treatment group | Control group | t | P |
0th week | 6.22±0.19 | 6.13±0.16 | 2.710 | 0.547 |
2nd week | 6.14±0.2 | 6.08±0.17 | 1.531 | 0.212 |
4th week | 5.69±0.19 | 5.85±0.20 | 6.215 | 0.042 |
From table 4, it can be seen that treatment starts pH value no significant difference (P > 0.05) at preceding two groups of lesions of patients, have comparable
Property.After treating 2 weeks, treatment group and control group pH value no significant difference;After treating 4 weeks, two groups of pH value have notable difference, compound
Durian peel ointment group pH value is decreased obviously, and shows that this group of patient can reduce pH at skin lesion by externally used compound durian peel ointment
Value, makes skin be gradually restored to normal weak acidic condition (pH=5.5).
Transepidermal water loss amount (TEWL) is as shown in table 5.
5 transepidermal water loss amount (TEWL) of table
Treatment time | Treatment group | Control group | T | P |
0th week | 19.61±3.15 | 18.83±3.32 | 3.324 | 0.103 |
2nd week | 16.41±2.81 | 16.47±2.59 | 0.305 | 0.039 |
4th week | 12.60±1.54 | 14.40±2.06 | 11.226 | 0.001 |
As can be seen from Table 5, treatment starts TEWL value no significant difference (P > 0.05) at preceding two groups of lesions of patients, and having can
Compare property.It is variant (P > 0.05) to compare the two TEWL value after treating 2 weeks, treatment group's transepidermal water loss amount, which is less than, to be compareed
Group.It treats 4 Zhou Hou treatment group TEWL values decline degree and is substantially better than control group, show to get over using the compound durian peel ointment course for the treatment of
Long, transepidermal water loss amount is fewer, to be effectively improved the symptoms such as dry chap.
Do not occur any adverse reaction during treatment group's patient medication, control group there are 6 patients slight pharmacological dependence occur
There is rebound phenomenon after being discontinued in phenomenon, 4 patients.
In conclusion compound durian peel ointment provided by the invention and preparation method thereof, can be effectively improved AD patient and face
Bed symptom, improves keratoderma water content, reduces percutaneous loss of moist amount, restores weak acidic condition at skin lesion, greatly improves skin
The moisture-retaining capacity of skin is gradually recovered the normal barrier function of skin.The medicine late result is obvious, and has no adverse reaction, and can grow
Phase uses, and is worth clinical application and popularization.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalents made by bright description are applied directly or indirectly in relevant technical field, are similarly included in this hair
In bright scope of patent protection.
Claims (5)
1. a kind of compound durian peel ointment, which is characterized in that the raw material including following parts by weight: durian peel stoste 100~200
Part, 55~95 parts of purslane Radix Glycyrrhizae mixture, 1800~2200 parts of albolene, 400~500 parts of atoleine, lanolin 30
~50 parts, 15~25 parts of Tween 80 and 16~28 parts of triethanolamine.
2. compound durian peel ointment according to claim 1, which is characterized in that the raw material including following parts by weight: durian
150 parts of skin stoste, 75 parts of purslane Radix Glycyrrhizae mixture, 2000 parts of albolene, 450 parts of atoleine, 40 parts of lanolin, tween
80 20 parts and 22 parts of triethanolamine.
3. the preparation method of compound durian peel ointment of any of claims 1 or 2, which is characterized in that by durian peel stoste, dent
Amaranth Radix Glycyrrhizae mixture, Tween 80 and triethanolamine are mixed, and the first mixture is obtained;First mixture is heated to 28
~32 DEG C, atoleine then is added into first mixture, obtains the second mixture, second mixture is first added
Heat is subsequently cooled to 38~42 DEG C to 75~85 DEG C;Albolene and lanolin are mixed, third mixture is obtained, it will
The third mixture is first heated to 75~85 DEG C, is subsequently cooled to 38~42 DEG C;By 38~42 DEG C of the second mixture and 38
~42 DEG C of third mixture is mixed, and the compound durian peel ointment is obtained.
4. the preparation method of compound durian peel ointment according to claim 3, which is characterized in that mix durian peel and water
It closes, decocts 1~3h, then isolated first filtrate and the first filter residue;First filter residue is mixed with water, continues decoction 1
~3h, then isolated second filtrate;First filtrate and the second filtrate are mixed, the first mixed filtrate is obtained,
First mixed filtrate is concentrated, obtains the durian peel stoste, the density of the durian peel stoste is 1.25~
1.3g/cm3。
5. the preparation method of compound durian peel ointment according to claim 3, which is characterized in that by purslane, Radix Glycyrrhizae and
Water mixing, decocts 1~3h, then isolated third filtrate and third filter residue;The third filter residue is mixed with water, continues to decoct
1~3h is boiled, then isolated 4th filtrate;The third filtrate and the 4th filtrate are mixed, the second mixing filter is obtained
Second mixed filtrate is concentrated liquid, obtains the purslane Radix Glycyrrhizae mixture, the purslane Radix Glycyrrhizae mixture
Density is 1.25~1.3g/cm3。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910010761.8A CN109432163A (en) | 2019-01-07 | 2019-01-07 | A kind of compound durian peel ointment and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910010761.8A CN109432163A (en) | 2019-01-07 | 2019-01-07 | A kind of compound durian peel ointment and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109432163A true CN109432163A (en) | 2019-03-08 |
Family
ID=65542300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910010761.8A Withdrawn CN109432163A (en) | 2019-01-07 | 2019-01-07 | A kind of compound durian peel ointment and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109432163A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08151325A (en) * | 1994-11-28 | 1996-06-11 | Sunstar Inc | Antimicrobial preparation |
-
2019
- 2019-01-07 CN CN201910010761.8A patent/CN109432163A/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08151325A (en) * | 1994-11-28 | 1996-06-11 | Sunstar Inc | Antimicrobial preparation |
Non-Patent Citations (2)
Title |
---|
杨玉峰: "复方榴莲皮软膏对特应性皮炎患者皮肤屏障功能修复的临床研究", 《河北中医药学报》 * |
黄晶: "复方榴莲皮软膏对120例特应性皮炎皮肤屏障功能修复的临床研究", 《黑龙江中医药》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103463539B (en) | A kind of medicine for the treatment of eczema and its production and use | |
CN106031756A (en) | Compound amur cork-tree temperature-sensitive gel for treating sore and ulcer and traumatic infection and preparing method thereof | |
US20200101128A1 (en) | Composition, preparation method thereof, and application thereof in the prevention and treatment of mammary gland disease | |
CN104784223A (en) | Composition with itching removing function and preparation method thereof | |
JP2015504915A (en) | Composition and use thereof in the treatment of anal fissure | |
CN105943666B (en) | Composition for nursing sensitive skin of infant and preparation method thereof | |
CN107184703A (en) | A kind of three sub- anti-itching lotions and its preparation technology and application | |
CN103040928A (en) | Medicine for treating chronic eczema, dermatitis and keratoderma, as well as preparation method and application thereof | |
CN109432163A (en) | A kind of compound durian peel ointment and preparation method thereof | |
CN100394919C (en) | Medicinal composition for treating vagina disease | |
CN1814201A (en) | Chinese-medicine cataplasma for treating cervical vertebra disease and preparing method | |
CN101559046A (en) | Therapeutic action of micromolecule sugar alcohol composite on nasal disease | |
CN101439092B (en) | Preparation method of navel paste for treating diarrhea, enuresis, night sweat and spontaneous perspiration | |
CN101019981B (en) | Chinese medicine preparation and its preparing process | |
CN102423342A (en) | Medicinal composition for preventing and treating skin eczema and skin pruritus, formulation and application | |
CN105395436A (en) | Acne cream and preparation method thereof | |
CN104840404A (en) | Cosmetic with deodorization function and preparation method thereof | |
JP7362140B2 (en) | Chinese herbal medicine topical patch for treating gouty joint pain and its preparation method | |
CN102028873B (en) | Tannin berberine gel for treating cervical erosion and preparation process thereof | |
CN116327669B (en) | Acne-removing composition with skin barrier repairing function and preparation method thereof | |
CN115969922B (en) | External traditional Chinese medicine composition for atopic dermatitis and eczema, dehumidification paste based on external traditional Chinese medicine composition and preparation method of dehumidification paste | |
CN114377079B (en) | Traditional Chinese medicine skin-moistening composition and preparation method and application thereof | |
CN102488867A (en) | Novel application of pharmaceutical composition | |
CN117018158B (en) | Graphene acupoint plaster for warming uterus and relieving pain as well as preparation method and application thereof | |
WO2022194168A1 (en) | Use of traditional chinese medicine composition in preparation of drug for preventing or treating chronic skin ulcer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190308 |
|
WW01 | Invention patent application withdrawn after publication |