CN109418991A - Tea seed cake tea Pu is used for the application method of food and health care product - Google Patents
Tea seed cake tea Pu is used for the application method of food and health care product Download PDFInfo
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- CN109418991A CN109418991A CN201811024833.6A CN201811024833A CN109418991A CN 109418991 A CN109418991 A CN 109418991A CN 201811024833 A CN201811024833 A CN 201811024833A CN 109418991 A CN109418991 A CN 109418991A
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- tea
- seed cake
- tannin
- tea seed
- food
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- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 235000020339 pu-erh tea Nutrition 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012958 reprocessing Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100001265 toxicological assessment Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229930182493 triterpene saponin Natural products 0.000 description 1
- 150000008130 triterpenoid saponins Chemical class 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 235000020334 white tea Nutrition 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 229960003487 xylose Drugs 0.000 description 1
- 235000020338 yellow tea Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3472—Compounds of undetermined constitution obtained from animals or plants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention is to extract tea seed cake tea Pu without any chemical reagents, and after impurity elimination is dry, pure physical method carries out crushing or ultra-fine grinding;Then to the powder product after processing, the content of tea polyphenols, tea tannin or procyanidine therein and Tea Saponin isoreactivity composition is detected;Then powder product directly or is added after excipient appropriate processing after appropriate dosage forms, is made food grade additives, directly adds use by the dosage of 0.1-10%;Or it is orally taken in right amount daily by health care product;Preparation method of the present invention is simple, and production cost is low;Purposes is wide, easy to use, easily popularizes.
Description
Technical field: the invention belongs to Camellia Plants byproduct processed and applied field, it is related to directly using tea seed cake tea Pu
In the application method of food and health care product.
16 arrived term involved in the present invention, term name, spy are explained as follows and explain;When this patent meaning
Term has with industry slang to conflict, and approval is given in its complete general character of industry slang or common part, invention per capita;If industry slang
Definition and intension itself and unintelligible or when without standard common recognition, be subject to the following definition of inventor, and first choice makees generalization
Or expansionary explanation, unless otherwise particularly illustrating, the word explanation power for finally having discrimination to discuss returns inventor herein and Shen
It asks someone to own.
1. tea oil tree: also referred to as camellia tree refers in Theaceae (Theacea) Camellia (Camellia.Linnaeus) plant
Seed oil content is higher, fruit is used to extract oil, and has certain cultivation to manage the perennial arbor of area or the general designation of shrub species.
Including being distributed most wide C. olelfera (C.Oleifera Abel), camellia meiocarpa (C.meiocarpa), Yunnan camellia
(C.reticulata), Camellia chekiangoleosa (C.chekangoleosa), Camellia yuhsienensis (C.yuhsiensis) and Camellia Vietnamensis
(C.vietnamensis) etc. local oil tea also includes having both the ornamental and difunctional all kinds of camellia trees of oil-producing.
2. tea tree: also referred to as tea tree refers to Theaceae (Theaceae) Camellia Camellia Sinensis (Linnaeus)
O.Kuntze plant;Its leaf or bud can directly steep drink after suitably processing with boiled water;Including green tea (Longjing tea, green tea, Huang
Shan Maofeng, all even high-quality green tea etc.), black tea (β-glucosidase, souchong, broken black tea etc.), oolong tea (extra-strong tea, Wuyi
Rock tea, phoenix single tea etc.), white tea (silver tip pekoe tea, white peony tea, tribute mee tea etc.), (Meng Dinghuang young tea leaves, Huoshan are yellow for yellow tea
Young tea leaves, Junshan Silver Needle Tea tea etc.), dark green tea, all kinds of tea trees such as Pu'er tea.
3. tea seed: being the seed of tea fruit including camellia oilseeds (also referred to as tea seed) and tea seeds;Tea seed episperm in tea seed (
Claim tea seed inner casing) account for about the 1/3 of tea seed total weight, tea seed kernel (also referred to as tea benevolence) accounts for about the 2/3 of weight.In dark brown or black,
It is in triangular shape more, it is glossy;Tea seed outer layer is exosper or is shell, that is, tea (fruit) Pu;It should be noted that
It is known as tea seed episperm in some documents delivered, is substantially exactly tea Pu, to take more care, to prevent obscuring, mistake is caused to sentence
It is disconnected.
4. tea seeds: the fruit for all kinds of tea (leaf) tree drunk in i.e. daily is the byproduct of Tea Production.
5. tea Pu: or tea fruit Pu, some places are also referred to as tea bag;Refer to the exocarp of camellia oleifera fruit or tea seeds
(shell), pericarp are in oblate or olive shape more.Account for about the 2/3 of tea fruit total weight;It in this patent, not only include above-mentioned tea oil tree
The pericarp (big and thick exosper, alternatively referred to as tea fruit shell) of fruit and tea seeds;It also especially emphasizes simultaneously, the tea Pu in this patent
Further include the inner casing (thin small endotesta, alternatively referred to as tea seed episperm) of tea seed and tea seeds, tea seed inner casing weigh about for tea seed it is total
The 1/3 of weight.
6. tea seed cake: its essence be exactly during tea seed is processed as tea oil or after remaining all solids
Leftover bits and pieces belongs to byproduct;It is the tea seed cake of broad sense, including Oil-tea-cake, Extracted From Oil-tea-cake, the tea seeds dregs of rice and tea seeds in this patent
Cake;Some places are also referred to as tea bran, tea seed cake, cake of camellia oleifera seeds, camellia seed meal;Or tea seeds bran (the withered, dregs of rice, cake);Oil extracting process has wood
It squeezes and machine squeezes or chemical method extraction;Claim the dregs of rice after claiming cake, chemical solvent to leach after usual mechanical-physical squeezing.Tea in this patent
The dregs of rice, not by any technique for extracting Tea Saponin, i.e., so-called such as detoxification, detoxification or the reprocessing of other techniques of fermentation;This
Signified tea seed cake in patent including also including tea cake, after crushing because of tea cake, with regard to powdering tea seed cake, substantially can be considered composition
It is identical or equivalent.Tea seed cake is mainly lived in tea seed cake because of the difference of Producing Area Soil, weather, kind, processing method and detection method etc.
There is some difference for sexual element content, as in tea seed cake the content of Tea Saponin 10% or more, it is high up to 18% or so or
Higher, customary amount is 15% or so;For tannin (tea polyphenols) content 1.0% or more, some may be up to 2.0% or 3.0%;Tea
The dregs of rice are usually all in puce or filbert;There is pie, sheet, particle, fine-powdered, occasionally there are a variety of physical aspects such as sheet;Including
Tea seed cake containing Residual oil and without Extracted From Oil-tea-cake;Including band grass tea seed cake and without careless tea seed cake.
7. caffein powder: the powdery after the powdery after tea seed cake or its processing, with tea Pu or its processing is mixed in a certain ratio
At powder or powder through being reprocessed into, referred to as caffein powder, in favor of this term of accurate understanding.
8. tea oil: using tea seeds or oil tea (camellia) seed as raw material, the oil that is obtained by the methods of squeezing and/or extracting
Product.
9. tea polyphenols Tea Polyphenols: referring to all kinds of positions in tea (leaf) tree and tea oil tree, molecular structure
In have the plant component general names of several phenolic hydroxyl group;Including flavonoids, tannin (including condensed tannin, also referred to as procyanidine),
Anthocyanin and phenolic acid (containing depside) etc.;Its source includes the Theaceaes plant parts such as tealeaves, tea seed cake, tea Pu.
10. tannin Tannin: also referred to as tannin, other field are also referred to as tannin extract;It is one kind of plant polyphenol, traditional definition
Refer to " the soluble phenolic compounds of energy precipitating proteins (further including alkaloid, gelatin);Usually molecular weight 500~
Phenolic compound between 3000 or even 5000.
11. procyanidine Proanthocyanidins (PC): belonging to for condensed tannin (CT), also someone is known as former pattern
Element is the polyphenol compound being formed by connecting by monomeric flavan -3- alcohols material with different polymerization degree, by different numbers in structure
Amount catechin or epicatechin are combined into;Usual procyanidine is catechin or epicatechin or catechin and epicatechin
The dimer of formation or three, the tetramer;Two~pentamer is known as oligomer (abbreviation OPC) at present, six aggressiveness or more are claimed
For point of high polymer (PPC).Current study show that procyanidine has extensive biochemical and pharmacological activity, such as anti-oxidant, removing
The functions such as free radical, liver detoxification, antibacterial and anticancer have become medicine, the important source material of health care product and food, makeup at present
The important additives of product.
12. Tea Saponin Tea saponin: also referred to as tsubakisaponin or Sasanguasaponin are Theaceae Camellia Plants (including oil
Tea and tea tree etc.) in all kinds of saponin unified address, based on the similar Triterpenoids sapogenins saponins of structure it is same
It is mixture;Monomer structure is made of sapogenin, sugar chain, uronic acid or organic acid, the general character with saponin.Tea Saponin has
Toil pungent, it will be apparent that stimulation schneiderian membrane and has many characteristics, such as hemolytic, by some nutrition experts be considered anti-nutrition because
Son.
13. flavone compound Flavonoids: narrow sense refers to that parent nucleus is a kind of compound of 2- phenyl chromone, referred to as
Flavone compound.Usually yellow, 4 have ketone carbonyl group, and most common is exactly 2 one phenyl chromones (2- phenyl benzo
γ pyranone) class, i.e. flavonols;Broad sense refers to one kind made of all two phenyl ring (A ring, B ring) are interconnected by three carbochains
Composition is known as flavone compound.Mostly with the basic framework of 6C-3C-6C, and often there are hydroxyl, methoxyl group, methyl, iso-amylene
The substituent groups such as base.Flavone compound includes above two definition in this patent.
14. the detection method of component content and relevant item in tea seed cake tea Pu, if without specified otherwise, first choice by with laxative remedy into
Row detection.
1) tea polyphenols detect: can refer to GB/T 8313-2008 standard or other food grade products national standard methods carry out
Detection.
2) Tea Saponin is detected using the gravimetric method that water-saturated n-butanol extracts, or is examined by HG/T 4492-2013
It surveys.
3) tea seed cake is detected the volume of produced foam by GB/T 7462.
4) tannin is measured by the national standard of GB/T15686-2008 or LY/T1083--2008 standard test.
15.Hormesis: Chinese is translated into hormesis or low dosage promotes effect;It is for describing virulence factor
Technical term.This dose-effect relationship model, neither most threshold models is applied in traditional poisonous substance risk assessment
(threshold model), nor linear non-threshold model (linear non-threshold model), but two-phase agent
Graded effect model, intoxicating factor (such as noxious material) has organism when alternatively referred to as U-shaped or J-type curve model, i.e. high dose
Evil, and it is beneficial to organism when low dosage.
16. the dosage effect mode of tea seed cake tea Pu complies fully with the two-phase Dosg-response Model of Hormesis
Background technique (one): the background of related introduction about tea seed cake
China is oil tea big country, and annual tea oil yield is about 500,000 tons according to statistics, while oil tea by-product that is adjoint and generating
It samples tea about 1,500,000 tons of the dregs of rice;For oil tea how long in southern hilly area, deep processing ratio is all little, at present major part tea seed cake still by
As agricultural fertilizer, fish pond pool-cleaning agent come using;Also some is used as raw material, therefrom extracts the Tea Saponin of high concentration,
The industries such as knit, dig up mine for washing, pesticide, building materials.China is also to produce tealeaves big country simultaneously, can produce tea seeds about every year according to statistics
It is 800,000 tons, about 100,000 tons of tea leaf oil;Ten thousand tons of the nearly 60-70 of tea seeds grouts generated together simultaneously.Tea seed oil is also made simultaneously
For for the approval of the new resource food acquisition Ministry of Public Health in 2009, tea seed oil byproduct, i.e. the tea seeds dregs of rice are also more and more.
In recent years, people are more for the exploitation concern of camellia oil and tea seed oil, while to the exploitation of two class tea seed cakes benefit
With also paying attention to gradually.From the point of view of two class tea seed cake compositions, contain about 12-18% crude protein, the total reducing sugar more than 30%, minerals member
The multiple components such as element, it should feedstuff, but the tea soap due to usually containing higher concentration (10-18%) in tea seed cake can be become
Element, a certain amount of tannin, the alkaloid and flavones of 1.0-3% and 30% or so cellulose, have strong impulse and
Pungent bitter taste, palatability is very poor, cannot directly eat;The Tea Saponin in tea seed cake and tannin etc. are considered by some experts simultaneously
Anti-nutritional factors to influence the scientific knowledge to tea seed cake, and then influences the reasonable employment of tea seed cake.
Technical specialist is just keen in industry at present, and using different process and method, all kinds of active matters are extracted from tea seed cake
Matter, such as Tea Saponin, tea polyphenols or tannin, flavone compound, tea seed polysaccharide, tea seed albumen etc. have simultaneously delivered a large amount of technology text
Chapter has applied for many patents of invention.It is " a kind of high-purity as filed in Hefei Xinda film Science and Technology Ltd. on 08 20th, 2017
Spend the extracting method of Tea Saponin " patent;Xinyang Normal College's Hua Rui institute height is equal to " one filed on 01 18th, 2016 into brave
The fast preparation method of flavonoid glycoside in kind Extracted From Oil-tea-cake ".
Below first in tea seed cake several main active ingredients and the prior art briefly introduce:
The first main active ingredient Tea Saponin.The content range of Tea Saponin has plenty of 10-18% in document report tea seed cake,
Some is 12%-18%;The reason of this species diversity: on the one hand related with the places of origin of raw materials and processing technology;Another aspect and tea soap
The detection method of element is related;In gravimetric method detection, the detected value of ethanol extraction method is than the detected value of n-butanol extraction method
It is high;This is because can also contain other compositions such as flavonoids, tannin in ethanol extract;And mainly it is exactly in n-butanol extract
Tea Saponin.Tea Saponin content is high in tea seed cake, there is very strong toil pungent, easily schneiderian membrane is stimulated to cause sneeze;Palatability is poor, moisture absorption
Property is stronger.
Zhang Xinghai 2003 " Tea Saponin property and application study recent developments " and river and source 2007 " property of Tea Saponin,
Preparation and application " article in all introduce, Tea Saponin is a kind of natural nonionic surfactant, have well stable cream
Change effect, foaming capacity, also there are the drug effects such as the unexistent sterilization of other surfaces activating agent, anti-inflammatory, analgesia, impervious.Zhang Xinghai
Article be also mentioned that Tea Saponin can stimulate the secretion of animal hormone in vivo, such as adrenal gland and matter hormone (corticosterone), due to skin
Matter sterone is very strong to carbohydrate metabolism, can promote gluconeogenesis and gluconeogenesis, inhibits the utilization of blood glucose, therefore can make blood glucose
It is temporarily increased.Tea Saponin can also reduce the cholesterol levels in liver and serum, thus have effect for reducing blood fat.
" the biological activity of Tea Saponin and its in animal productiong of Zhan Yong patent ZL96193005.5 and Hao Yuanhua 2015
Application study progress " all refer to that Tea Saponin has enhancing immunocompetence, and have effects that oxidation resistant.
Second of composition tea polyphenols, refers mainly to tannin.In tea seed cake content be 1.5% or so, range can energy content be 1-
3%;Tea seed cake tannin by some experts is considered anti-nutritional factors because of its astringent taste;But the polyphenol hydroxyl chemical structure and uniqueness of tannin
Chemical property so that tannin is showed stronger oxidation resistance.Additionally while tannin can be with carbohydrate, amino acid, albumen in feed
Matter and iron ion etc. mutually adsorb, but this absorption is reversible, and is easily desorbed in acidic environment.Tannin has been approved for
Food additives;Vegatable tannin is typically considered safe.Tannin also belongs to the scope of tea polyphenols, and tea polyphenols have been put into
In national standard GB2760-2007 " food additives use sanitary standard ", major function is antioxidant.Open source literature introduces oil tea
Tannin also has antibacterial and antiviral, the multiple efficacies such as resisting cardiovascular disease.Using with natural antibacterial in field of food
The effect of anti-corrosion, can be used in liquid beverage as stabilizer, be alternatively arranged as the raw material of health food.
The third active ingredient flavonoids.Flavones content has been reported that about 0.2% in tea seed cake, and also some is reported as
1.3%, there may be substantial connection with detection method, have bitter taste;There is open source literature to show the flavone compound in tea seed cake simultaneously
Mainly Kaempferol, naringenin and its derivative etc..The text that such as Chen Hongxia is delivered in 2011 " chemistry of forest product and industry "
In chapter " separation of flavonoid glycoside compound and Structural Identification in cake of camellia oleifera seeds ", it is indicated that flavonoid glycoside is mainly kaempferia galamga in cake of camellia oleifera seeds
Phenol 3-O- [2-O- β-D- galactolipin -6-O- α-L- rhamnose]-β-D-Glucose glycosides and be Kaempferol 3-O- [2-O- β-D- wood
Sugar -6-O- α-L- rhamnose]-β-D-Glucose glycosides.
Hou Liuxin etc. published an article in " Food Science " a kind of " the separation mirror of novel tea seed flavones monomer in 2013
Fixed and its antioxidant activity " in, be separated to new flavone compound, i.e. naringenin -7-O- (β-D- xylopyranosyl (1 →
6)) (β-D-Glucose base (1 → 3)-α-L- rhamnopyranosyl (1 → 2))-β-D-Glucose glycosides.Rivers source etc. was in " tealeaves in 2005
Science " on publish an article " in teaseed cake dregs flavonoid glycoside HPLC analysis, preparation with MS identify " in, it is indicated that the Huang in teaseed cake dregs
Ketoside mainly has kaempferol-3-O-rutinoside and Kaempferol -3-O- (6-O- β-D- glucopyranosyl;)-β-D- galactolipin
Two kinds of glycosides.
In a kind of " the preparation side of flavonoid glycoside in middle compression leg quick separating cake of camellia oleifera seeds Wang Chengzhang granted patent 101899070B
Method " and Gao Jinyong number of patent application 201610027047.6 " fast preparation method of flavonoid glycoside in a kind of Extracted From Oil-tea-cake " document
In, it introduces in tea seed cake also containing flavonoids natural activity composition, there is anti-inflammatory, anti-oxidant, female hormone sample effect and anti-
Bacterium and antiviral and other effects, and vasodilation can be made, protect heart and brain;Improve memory, anti-depression anxiety and neuroprotection etc. are a variety of
Physiological activity, flavonoids is existing to be much developed to novel plant medicine, such as Total Ginkgo Flavone-Glycoides, and has the work of solution toxin for liver
With.
4th kind of active ingredient: ceramide.In addition Japan Patent JP2004189683 and Guilin Sun Buxiang is awarded
It is described in power patent 102058727B " tea seed extract containing ceramide and preparation method thereof " in tea seed cake also containing one kind
Natural ceramide, and refer to that ceramide is a kind of bimolecular lipid layer component, belong to the lipid structure unit of sphingomyelins
One of, there is important biological action, such as courier's effect and active cell apoptosis, is adjusting Apoptosis, cell differentiation, transhipment
And proliferation etc. has certain function.Somebody thinks such as controlling cancer, neurasthenia, diabetes, obesity and inflammation
It can also play a role Deng during.
The alkaloids such as the 5th kind of active ingredient caffeine.The caffeine for containing about 1% in tea seed cake belongs to the alkalization of xanthine biology
Close object;Containing alkaloid about 1.5-3%, (nitrogenous alkaline organic compound, majority have complicated cyclic structure, nitrogen packet in tea seed cake
Be contained in ring) its biological activity may be natural with other organic compounds containing nitrogen (such as vitamin B1), have it is a variety of
Physiological function.Alkaloid has bitter taste, and such as caffeine, it is also a kind of central nervous excitation agent simultaneously, and appropriate intake is that pole has
Benefit.
In addition there are also tea seed albumen about 12-20%, tea polysaccharide about 30% and beneficial trace mineral elements in tea seed cake
Deng.
The generally existing direct or indirect prejudice to tea seed cake in industry: may be since tea seed cake is considered as low-grade agriculture
Byproduct, so far, tea seed cake itself also never defend planning commission by country and are approved as new resource food, and food additives are protected
The food of health food raw material or food and medicine consangunity, the country also do not have the habit of edible tea seed cake Anywhere, that is, generally believe tea seed cake
Inedibility;It needs to extract wherein corresponding effective active components, be possible to human consumption or make medical usage.In addition tea
The dregs of rice are the agricultural and sideline products of edible oil factory, also the Ministry of Agriculture and are not being defended on the product blacklist that planning commission is forbidden to use;Tea seed cake its eating
Condition closes jural situation and belongs to grey edge zone, changes an angle, in terms of the strategic perspective of development, should belong to anxious to be developed
The high-quality resource product utilized.
In addition because tea seed cake has strong impulse and pungent bitter taste, palatability is very poor, influences animal feed intake, even
Animal food refusal commonly thinks that tea seed cake is toxic in animal feed circle, cannot be directly used to feed, tea seed cake is only in detoxification or detoxification
Afterwards, it can just use in feed.Just because of above-mentioned reason and some prejudice, tea seed cake never obtains in food and health care product
Using also not seeing has document report directly to use tea seed cake as food additives or health care product, or in practical life
Directly tea seed cake will be used as food additives or health care product in work.
Background technique (two): the background of related introduction about tea Pu
China is oil tea big country, and the yield of annual oil tea Pu is up to more than 400 ten thousand tons according to statistics;In addition, China is also to produce
Tealeaves big country, tea seed oil are also used as new resource food acquisition Ministry of Public Health approval in 2009, the byproduct of tea seed oil, tea seeds
Shell, i.e. tealeaves Pu also can be more and more.A large amount of tea Pu (being originated from tea oil tree and tea tree) uses usually as fuel, only
It is a small amount of to be used to produce the industrial chemicals such as furfural, xylitol, active carbon and for culturing edible fungus.It is numerous research shows that tea Pu Zhongzhu
To contain cellulose, hemicellulose, lignin, pectin, can also claim containing abundant tea polysaccharide and dietary fiber;Simultaneously containing richer
Rich tannin (also someone is known as tannin, based on condensed tannin, belongs to the main ingredient of tea polyphenols) and a small amount of Tea Saponin and
Flavonoids isoreactivity composition.
Active ingredient tea polyphenols (tea tannin, procyanidine), Tea Saponin, tea flavones of tea Pu etc. and existing skill is described below
Art.
One: tea polyphenols (Tea Polyphenols), definition is the general name of polyphenols in plant of theaceae, according to poplar
Introduction in virtuous strong " tea polyphenols chemistry ", tea polyphenols mainly include flavanol compound (also referred to as condensed tannin or tea tannin), pattern
The four class compositions such as glycoside (some is also referred to as anthocyanidin or anthocyanidin), flavonoids (containing flavonols) and phenolic acid (containing depside) class;
It is mainly mostly important with flavanol compound (i.e. catechin), and be in the great majority, account for about the 60%--80% of tea polyphenols total amount;Catechu
Element is the general name of polyhydroxy flavan-3-alcohol.
Tea polyphenols are in anti-oxidant, anti-inflammatory, anti-radiation, anti-aging, prevention cardiovascular and cerebrovascular disease, anti-curing cancers, liver protecting
And preventing decayed tooth etc. is all powerful;And it can be used as antioxidant, protect fragrant and color preserving agent.
Liu Dongying large and small mouse acute toxicity test in " toxicological assessments of tea polyphenols " text in 2009 shows
Tea polyphenols Acute oral tox-hty test LD50 > 10g/kg (BW), the true nontoxic grade in border.
Two: tannin
1. definition and source: being one kind of plant polyphenol, traditional definition refers to that " energy precipitating proteins (further include biology
Alkali, gelatin) soluble phenolic compounds;It is a kind of polyphenol compound for having specific structure and specific function, is that plant exists
The one kind time formed in existence adaptation process in order to resist the stress of the microorganisms such as virus, mushroom or animal attack or environment
Raw metabolite, it is plant interior accumulation " secondary compound " that these compounds, which are not involved in the main metabolic function of plant, but
They play the defense function of plant;It can be used as a kind of effective protective agent, prevent the injury of virus, microorganism or animal, because
And also referred to as protective plant protecting agent.
2. structure and classification: whether can be hydrolyzed by tannin, tannin is divided into Hydrolysable Tannins (Hydrolysable
Tannins, HT) and condensed tannin (Condensed Tannins, CT).Hydrolysable Tannins be by gallic acid and its derivative with
The compound that glucose or polyphenol are formed by ester bond;It is met acid, alkali or enzyme and is easy hydrolysis generation small-molecule substance, product
For gallic acid or ellagic acid and glucose.Condensed tannin is the tannin of not facile hydrolysis, be formed by the condensation of flavanols it is poly-
Object is closed, 2 of flavanols are by carbon-carbon bond in conjunction with catechol or benzenetriol in molecule;Without containing saccharide residue.
3 main features: the polyphenol hydroxyl chemical structure and unique chemical property of tannin have tannin very strong anti-oxidant
Function;Another feature is that association reaction occurs by hydrophobic bond and numerous hydrogen bonds and protein, causes to precipitate.
4 function and usages:
1) tannin can effectively inhibit common some pathogens, such as salmonella, Escherichia coli, and pathogen is inhibited to exist
The field planting of enteron aisle.Tannin is not only in that it has apparent antibacterial effect, and is that bacterium is not likely to produce tolerance to it.
2) tannin has convergence, can effectively prevention and control (prevention and treatment) animal and people diarrhea/have loose bowels;Tannin passes through suppression
The convergent double action of enteric pathogenic bacteria and physics processed effectively controls rapidly diarrhea, quick and significant effect.
3) tannin promotes the protein precipitation easily in conjunction with the intestinal wall protein inside helminth, influences helminth enteron aisle
Permeability and absorption, digestion, utilization to nutriments such as protein, amino acid;With certain killing or drive away parasitic
The effect of worm is natural antiparasitic.
4) tannic acid can be precipitated with generations such as metal, alkaloid and glucosides (see glycosides), have detoxication to these substances.
5) tannin or natural, antistaling agent, stabilizer, also can be used as the functional raw material of health food
6) tannin orally takes orally, can be used for preventing and treating diarrhea, enterorrhagia etc.;With hemostasis, callus.Tannin have it is antiviral,
Antiallergy, anticancer become, prevent and treat the pharmaceutical values such as cardiovascular and cerebrovascular disease;Chinese medicine containing tannin is to blood lipid, hemorheological property, blood platelet
Function etc. has improvement, there is saying for " activating microcirculation and removing stasis medicinal ";Tannin is in medicine once for treating sphagitis, tonsillitis, hemorrhoid simultaneously
Sore and skin blister disease etc..
The effect of tannin is various in a word: pre- anti-diarrhea, promotes intestinal health;Improve nutrient absorption;Improve body
Antioxidant status and strengthen immunity.
5 tannin side effects: tannin is usually negatively charged bioactive molecule, and easily and in saliva single positive charge protein occurs
Chemical reaction (hand-gloves mode) simultaneously precipitates, and oral cavity surface layer can be made to generate coarse convergence sense, feel dry and astringent, i.e. astringent taste, this is
A kind of defence mechanism that the plant property resisted animal or insect swallow.
1) when additive amount is high in food for tannin, because of its strong astringency, it will affect palatability.
2) tannin is seriously affected by generating deposit in conjunction with protein, carbohydrate, enzyme, metal ion to nutrition
It the digestion of substance and is absorbed and utilized, nutritive value can be reduced;Therefore anti-nutritional factors is considered by some experts.
6. the newest understanding about tannin
Although tannin can mutually be adsorbed with carbohydrate, amino acid, protein and iron ion etc., this absorption is reversible,
It is easily desorbed in the specific environment of enteron aisle.It is new research shows that: tannin is because having very strong polarity, easily and in conjunction with protein
The characteristic of compound not soluble in water is formed, and this compound is not soluble in water at pH value 3.5~7.5, can be stabilized;But
It is this compound, can be then decomposed rapidly below or above this range;I.e. when one protein complex of tannin flows through abomasum
(pH2.5) and when small intestine (pH8.0~9.0), protein is immediately disconnected with tannin, through pepsin and trypsin degradation, shape
At the small-molecule substance of easy absorption, and separates and release protein.
Tannin has been approved for food additives;Vegatable tannin is typically considered safe;U.S. FDA returns tannin
For GRAS product;Tannin also belongs to the scope of tea polyphenols, and tea polyphenols have been put into national standard GB2760-2007 " food additives
Use sanitary standard " in, major function is antioxidant.
Research shows that: the main reduction position of catechin is the ortho position phenolic hydroxyl group of its ring in tea polyphenols, and pyrogallol
The oxygen absorbed of type catechin is greater than catechol type, whereupon it may be inferred that the antioxidation of catechin has with its molecular weight
It closes;The bigger tea tannin of molecular weight, the polyphenol free radical generated is more stable, is not easy to cause new lipid oxidation chain reaction
Occur.Research shows that tea tannin anti peroxidation of lipid ability and its molecular weight and being positively correlated property of galla turcica phthalidyl number.In addition,
The dissolubility of tea tannin can also have a huge impact its antioxidant activity.The application of oil solvent type and aqueous solution type tea tannin
Studies have shown that the former has stronger lipid peroxidation inhibition activity compared with the latter.
Research shows that both including Hydrolysable Tannins in tea Pu, also contain condensed tannin, based on condensed tannin, belongs to natural
Mixed type tannin;In " extraction and its analysis Preliminary Report on Experiment of oil-tea camellia husks tannin ingredient " that especially Xu Man was delivered in 2009
Prove that the tannin content contained in oil tea shell reaches 11.06% through detection;Li Xiansheng et al. reports tannin (tan in oil-tea camellia husks
Matter) content be 9.23%.
Three: procyanidine
Definition: flavanols and its condensate with C6-C3-C6 structure are classified as condensed tannin, come from this patent
The tannin of plant of theaceae is also referred to as tea tannin.Be by different number catechin or epicatechin and gallate in conjunction with and
At;It is segmented into 1. epicatechin (Epicatechin EC) again by molecular structure, 2. epigallocatechin
(Epigallocatechin EGC), 3. L-Epicatechin gallate (Epicatechin gallate ECG), 4. table is not eaten
Sub- catechin and gallate (Epigallocatechin gallate, EGCG) etc. is several.By catechin in procyanidine
The number of monomer, i.e., can be divided into oligomer and high polymer by the size of the degree of polymerization again;Usually it is known as oligomer for two to pentamer,
Six aggressiveness or more are known as high polymer;High oligomer is that in contrast, the classification of different researchers slightly has difference.
Fu Ying published an article in 2009 the biological activity and its healthcare function of procyanidine " study " introduce former cyanine
Element has the characteristics that efficient, low toxicity, high bioavailability;It is to remove the very strong antioxidant of free radical, it is anti-oxidant, it removes certainly
By 50 times that the ability of base is VE, 20 times of Vc.Its half lethal dose is LD50==3g/kg (BW), and safety is very high.
The development test in 2009 such as Xie Wenli shows: the median lethal dose (LD50) of procyanidine is administered up in mouse
2.75g/Kg shows that procyanidine safety is very high
Discovery contains procyanidine in tea shell;It is the flavanols and its condensate with C6-C3-C6 structure, can removes
Superfluous free radical, improves the immunity of the human body in human body, can be used as anti-cancer, it is anti-be mutated, prevention and cure of cardiovascular disease drug mainly has
Imitate ingredient and as safe and non-toxic novel antioxidant.
The definition of four Tea Saponins is shown in that preceding terms 12, Tea Saponin cause tea Pu to have certain bitter pungent, and stimulation schneiderian membrane draws
Play sneeze;Palatability is poor.But Zhang Xinghai 2003 in " Tea Saponin property and application study recent developments " and river and source 2007 in " tea soap
Element property, preparation and application " article in all introduce, Tea Saponin is a kind of natural nonionic surfactant, critical
Micellar concentration (CMC) is 0.5% or so, has effects that well stable emulsification, foaming capacity, also has other surfaces activating agent
The drug effects such as unexistent impervious, anti-inflammatory, sterilization.The article of Zhang Xinghai is also mentioned that Tea Saponin can stimulate point of animal hormone in vivo
It secretes, as adrenal gland and matter hormone (corticosterone) can promote gluconeogenesis and Portugal since corticosterone is very strong to carbohydrate metabolism
Grape sugar is newborn, inhibits the utilization of blood glucose, therefore blood glucose can be made to be temporarily increased.Tea Saponin can also reduce the cholesterol in liver and serum
Level, thus have effect for reducing blood fat.Tea Saponin is the mixture of Triterpenoids sapogenins saponins similar in a class formation,
It is a kind of good surfactant, there is a preferable washing effect, while also there is haemolysis, anti-inflammatory, eliminating the phlegm, antimycotic, anti-prominent
The effect of change can be used as fungicide, insecticide, diuretics etc..
Five tea flavones flavonoids have anti-oxidant, removing free radical, antibacterial, anti-inflammatory, vasodilation protection heart and brain;Improve
Memory, a variety of physiological activity such as anti-depression anxiety and neuroprotection, flavonoids is existing to be much developed to novel plant medicine, such as silver
Apricot general flavone etc., and have good effects.
The prior art about tea Pu
One: the prior art of polyphenol, procyanidine (tannin, tannin) or antioxidant is extracted from tea Pu
1. introducing oil tea Pu in the patent 101961427B " while the method for extracting oil-tea camellia husk polysaccharide and polyphenol " of Xu Huaneng
Polysaccharide is the anti-oxidant and anti-tumor activity polysaccharide of a kind of great researching value and potentiality to be exploited.Oil tea Pu polyphenol characteristic component is
Gallic acid, ellagic acid and its derivative have preferable antioxidant activity, anticancer activity and safety.
2. Gan reflects etc. 2015 forever and delivers in " food industry science and technology ", " tea seed shell extract is anti-oxidant and anticancer activity
Research " show that polyphenol and flavones in tea seed shell have apparent anti-oxidation function and anticancer activity.
" extract from fruit shell of camellia oleifera abel anti-oxidant and Anticancer Activities " shows oil tea 3. article that Chen Ya fine jade etc. is delivered for 2010
Also contain ellagic acid (EA) and 3- methyl-ellagic acid -4 '-O- glucoside (MEAG) in Pu.
4.CN102641387A disclose " a method of from oil-tea camellia husks with supercritical process extract polyphenol ";
5.CN103393845A disclose " a method of using macroreticular resin separation oil-tea camellia husks in polyphenol ";
Red Army etc. delivers the article of " ultrasonic extracting process of polysaccharide and procyanidine in tea seed shell " for 2010 more than 6.;
7. woods deeply raw (1997) research shows that the acetone-water extract of oil tea shell has very strong inoxidizability, resist
Oxidizing component is mainly gallic acid and catechin.
8. a kind of " the side for extracting Natural Antioxidants from oil tea shell patent document CN 102210786A of Zhang Liangliang
Method " in show that there is very strong antioxidation biology there are procyanidine and former two kinds of configurations of delphinidin in oil tea shell proanthocyanidin
Active function.
9. 104083534 A of patent document CN " preparation method of tea seed shell procyanidine " of Sambucus chinensis.
10. illustrating oil in " extraction and its analysis Preliminary Report on Experiment of oil-tea camellia husks tannin ingredient " that Xu Man was delivered in 2009
Proanthocyanidin condensed tannin containing local galloyl in tea shell.
11. patent document CN107669817A " a kind of preparation method of the anti-enteritis micro-capsule of oil-tea camellia husks, product of dry little Ying
And its application " in illustrate oil-tea camellia husks in contain tannin, tannin is complicated polyphenol compound, have anti-inflammatory, antidiarrheal,
Hemostasis, anti-mutation, antitumor and other effects;Structure is complicated for oil tea tannin, is not likely to produce drug resistance, can be used as antibiotic substitution medicine
Object.
Two: the prior art of triterpenoid saponin or Tea Saponin is extracted from tea Pu
1. Wu Lei patent document CN107236018A title " from oil tea Pu extract oleanane-type triterpene saponin and its
Preparation method " in illustrate tea Pu and contain oleanane-type triterpene saponin, its chemical name is 27- hydroxyl -28-O- β-D-Glucoses
Base-oleanene -3-O- [a-L- rhamnopyranosyl (1 " → 2 ')]-β-D-Glucose glycosides, and there is unique disaccharide chain triterpene soap
Glycosides structure has significant antitumor action, can be widely used in the products such as antitumor medicine, food and health care product;This says
Active regenerator and huge potential quality of the bright tea Pu with cancer-resisting.
2. " one kind extracts Tea Saponin co-production polysaccharide to the patent document CN106810590A title of button a kind of jade star from oil tea Pu
Method " in illustrate Tea Saponin also known as tea saponin, belong to Triterpene saponins, there is emulsification, wetting, decontamination, foaming, foam stabilizing energy
Power, and do not influenced by water hardness, also there are the physiological actions such as impervious, anti-inflammatory, analgesia, anticancer.Oil tea polysaccharide has anti-simultaneously
The bioactivity such as tumour, anti-radiation, anti-oxidant, anti-aging.
Three: the prior art and application of Flavonoid substances are extracted from tea Pu
" one kind synchronous extraction from tea fruit shell prepares flavone aglycone and furfural to the patent of invention CN103923048B of Zhu Bairong
Method " illustrate in tea fruit shell containing the effective components such as chromocor compound, pentosan;Chromocor compound has antioxygen simultaneously
The multiple pharmacological effects such as change, anticancer, resisting cardiovascular disease.
" tea seed shell general flavone causes the guarantor of liver cell oxidative stress to aflatoxin B1 to the article that Wang Xiu is delivered for 2016
Shield effect and mechanism " show the damaging action that tea seed shell general flavone can be reduced aflatoxin B1 to liver cell.
Four: the prior art of polysaccharose substance is extracted from tea Pu
The patent CN101560266A of Shen Jianfu discloses " a kind of oil-tea camellia husk polysaccharide and application thereof ", shows oil-tea camellia husk polysaccharide
It is the anti-oxidant and anti-tumor activity polysaccharide of a kind of great researching value and potentiality to be exploited.
A kind of invention CN103030710B " method of oil-tea camellia husks resource utilization " of Chen Congjin, the invention is first by oil tea
Shell directly proposes method with alcohol extracting+water and extracts active constituent polyphenol and polysaccharide, or oil-tea camellia husks are used again through Microwave Pretreatment
Alcohol extracting+water proposes method and extracts active constituent polyphenol and polysaccharide, and residue is then added auxiliary agent again, hot in micro-wave oven or high temperature furnace
Solution prepares active carbon or pyrolysis prepares biological oil product or hydro-thermal process preparation bio oil and charcoal product.
Five: the prior art of other active ingredients is extracted from tea Pu
The patent 102139019B " purposes that extract from fruit shell of camellia oleifera abel prepares drug " of Shen Jianfu shows that extract from fruit shell of camellia oleifera abel has
Play the role of significantly inhibiting 5α-reductase activity, anti-prostatic hyperplasia, anti-prostate cancer, inhibit acne.Oil tea Pu mentions simultaneously
It takes object that there is physiology and the pharmacological activity such as significant free radical resisting, anti-oxidant, anti-radiation, protection cardiovascular and cerebrovascular, there is safety, nothing
The advantages that poison, performance are stable, long-term consumption is without side-effects.Can extract from fruit shell of camellia oleifera abel be compounded individually or with other auxiliary materials guarantor is made
Health food, drug or daily chemical product, the prevention and treatment for related disease.
Publishing an article within Xie Yong etc. 2013 " extraction of insoluble diedairy fiber and its specificity analysis in oil tea Pu " introduction can
Insoluble diedairy fiber (insoluble dietary fiber, IDF) in oil tea Pu is extracted, is applied in food industry, especially
It is in bakery.Dietary fiber can supplement the dietary fiber that human body is lacked as a kind of nutrient, addition in food;
When applied to health food development, the effects of IDF can play weight-reducing, coordinating intestines and stomach, relax bowel and defecation.
The patent document CN101695336A " tea seed episperm bioactive extracts application and preparation method " of Hu Guotian.
Existing tea Pu technological deficiency: all kinds of technical specialists of this field or adjacent areas are studying from tea Pu Zhongti at present
All kinds of active materials, such as tea polyphenols, tannin (tannin or tannin extract), flavones, Tea Saponin or tea polysaccharide are taken, and has been delivered a large amount of
Technical article has applied for many patents;But the above extraction process can only all obtain fractions of active ingredient;Part will be caused to provide
The waste or loss in source;No matter any solvent extraction is used simultaneously, usually all taken a long time, and needs to consume a large amount of organic molten
Agent, recycling design is sometimes more difficult, and postprocessing working procedures are many and diverse, and finished product needs to be dried in vacuo sometimes, so the cost of production is very high;
Some so-called patented technologies often have relatively strong denseer academic nature and advanced theoretical property, but usually and without real
Economic and practical and practical operability.As soon as some patents of invention are after authorization, do not continue to pay dues and automatic abandon patent within 2 years,
Far from the conversion and industrialization of patented technology achievement and authorize other people implement.Come from the essence of these patents of dying young
See, essentially from it, be compared analysis according to economics means, on stricti jurise for, just have real
It is poor quality patent with property and practical feasibility, some even may be considered rubbish patent, be intended merely to the undeserved reputation of patent
The patent application carried out with other improper lure by promise of gain, is not for practicability and achievements conversion.
There are technical problems for tea Pu: tea Pu is the front end waste of oil tea or Tea Industry, in oil tea or tea growing areas, tea
Pu comes mainly as fuel using as tea Pu is used to smoke wax meat by some tea growers when firewood is burnt;Many tea Pus or by discarded road
Side and the hilltop have a large amount of thamnolia vermicularia Pus to be dropped in a word, only a small amount of for producing the industrial chemicals such as furfural, xylitol, active carbon
And culturing edible fungus;It is extremely low currently with rate, 1% may be less than;It is very cheap in the price for originating in thamnolia vermicularia Pu, it is usually per ton
Only several hundred members;In the state not utilized or utility value is extremely cheap, the huge waste of resource is caused, or even causes environment
Pollution.Therefore the tea Pu containing abundant active ingredient does not obtain scientific and reasonable development and application, really inherent
Value is not widely recognized and confirms, unique biological activity value and potential huge medical value do not have more
It is fully embodied and is realized, belong to anxious rarity leaved for development.
The generally existing direct or indirect prejudice to tea Pu in industry: may be since tea Pu is considered low-grade agricultural and sideline
Product, so far, also never defend planning commission by country is approved as new resource food, food additives, health care to tea Pu itself
The food of raw-food material or food and medicine consangunity, the country do not have the habit of edible tea Pu Anywhere yet, that is, generally believe tea Pu not
Preferably eat;It needs to extract wherein corresponding effective active components, be possible to human consumption or make medical usage.In addition tea Pu
It is agricultural and sideline product, also the Ministry of Agriculture and is not defending on the product blacklist that planning commission is forbidden to use;Tea Pu its in food relevant law
Situation belong to grey edge zone, change angle in terms of the strategic perspective of development, should belong to the anxious high-quality money to be developed utilized
Product-derived.
Because of the irritant and pungent bitter taste of tea Pu, palatability is poor, influences animal feed intake, probably due to above-mentioned reason
And some prejudice, tea Pu are never applied in food and health care product, also not seeing has document report directly will
Tea Pu uses as food additives or health care product, does not more see in real life, will be directly by tea Pu as food additive
Agent or health care product is added to use.
Summary of the invention: tea seed cake tea Pu is directly used in the application method of food and health care product.
In chemical field, the prior art is all that tea seed cake and/or tea Pu are obtained tea seed cake using all kinds of extraction/abstraction techniques
And/or certain in tea Pu or certain active ingredients, then the technical solution developed and utilized.Especially in food, health care product, doctor
Medicine field, up to the present, it has not been found that having patent or document report: tea seed cake and/or tea Pu being directly used for food and health care
Product, and obtain the application method or purposes scheme of beneficial effect.Technical solution of the present invention is using with the above-mentioned prior art
Method, entirely different technical thought;Any extraction or extraction process are not had to, without any chemical extraction reagent, nothing
Any byproduct, residue or three industrial wastes product, the thinking of use are 100% complete utilization strategies, are harmless pure green physics
Disintegrating process;In short, being exactly that tea seed cake tea Pu is directly used in food and health care product with suitable dose, in other words
Be by tea seed cake and/or tea Pu, directly used as food additives or food auxiliary material, or directly as health product raw material or
Person is that health care product uses, and key problem in technology is the reasonable control of dosage.
Technical solution of the present invention or application method can be point three steps specifically for this;
The first step is: by after tea seed cake or tea Pu impurity elimination, it is dry, then carry out crushing or super-micro wall-broken crush;It can also incite somebody to action
Tea seed cake and tea Pu are mixed by a certain percentage before the two processing or both after processing, corresponding powder are made.
It is preferred that being crushed to 80-120 mesh;
Health care grade product is preferably crushed to 300 mesh, reaches ultramicro grinding.
Second step is: the powder obtained to the first step, and sampling carries out the detection of all kinds of component contents, and detection project is mainly wrapped
Include: Tea Saponin, tea polyphenols or tea tannin or procyanidine can also include tea flavones, polysaccharide, protein, dietary fiber sometimes
Deng.
Third step is: by the powder of step 1, being divided into food additive grade and health care grade by purposes, then carries out corresponding
Weighing and bagging or add customary adjuvant after carry out weighing and bagging, stick corresponding effective ingredient label and application method.
Application method (one): as health care product, by tea seed cake and/or tea Pu with fine powder form or with suitably common capsule form
It is orally ingested, tea tannin or the control of tea polyphenols intake is being no more than 100mg/kg (weight)/day;The intake control of Tea Saponin
System is being no more than 20mg/kg (weight)/day;
It is preferred that the amount of tea tannin or tea polyphenols is 10-20mg/kg (weight)/day;The amount of Tea Saponin is 1-4mg/kg (body
Weight)/day;
It is preferred that tea Pu dosage is 5-12 grams/day;
It is preferred that tea seed cake dosage is 0.8-3.2 grams/day;
It is preferred that caffein powder dosage is 1-10 grams/day.
Application method (two): as natural food-preservative and antioxidant in use, by tea seed cake and/or tea Pu with fine powder
Form is added in oxidizable or spoiled food raw material in the ratio of 0.1-10%, can effectively extend shelf life of products and holding
Freshness;It is preferred that adding tea seed cake or tea Pu or caffein powder in oxidizable or putrefactive raw-food material by 0.5--5%.
One of invention main points: it is all precious, effective ingredient in such as aforementioned two classes raw material that inventor, which thinks tea seed cake and tea Pu from head to foot,
Content is high.If tea polyphenols or tannin or procyanidine this depth content are just higher in tea Pu, as Xu Man delivered in 2009 " oil
The extraction of tea fruit shell tannin ingredient and its analysis Preliminary Report on Experiment " in through detection prove that the tannin content contained in oil tea shell is up to
11.06%;Li Xiansheng et al. reports that tannin (tannin) content is 9.23% in oil-tea camellia husks.It is at all unnecessary time-consuming and laborious with having
Solvent extracts;And the active ingredient having is difficult to extract completely by a kind of or two kinds of solvents;Direct powder
Broken or ultramicro grinding use, and be lost without any active constituent, all active constituents, including unique disaccharide chain
Triterpenoid saponin and a small amount of flavonoids, even minimal amount of ceramide, the rare biological activity such as squalene, all
Fully all risk insurance stays, no chemical lesion true with all risk insurance.
The two of invention main points, because effective active components are higher in tea seed cake and tea Pu, as Tea Saponin is about 15% in tea seed cake
Left and right;Tannin content average out to 8-11% in tea Pu;And tea seed cake and tea Pu all have irritation and pungent bitter taste, palatability
Difference;Dosage more greatly, then referred to as toxic or harmful or toxic side effect.And according to chief active contained in tea seed cake and tea Pu at
Part and its mechanism of action analyze and determine;For tea seed cake tea Pu to the dosage efficacy profile of human body, security compliance Hormesis is theoretical
Two-phase Dosg-response Model, the i.e. dosage range of the low dosage beneficial functional of tea seed cake tea Pu are minimum action agent theoretically
It measures (LOEL) to arrive without visible destructive dose (NOAEL), and the value of NOAEL is 10-20 times of LOEL value;And optimum efficiency dosage
It is 1/5th of NOAEL value.
Invention third key point: the concentration difference of effective ingredient in tea seed cake tea Pu raw material is fully considered;Optimizing raw material proportion or
It adjusts, quality fluctuation caused by avoiding because of materials variance can make the content of Tea Saponin in semi-finished product, tea polyphenols or tea tannin steady
It is fixed, there is specific analysis guarantee value, is conducive to the standardization and commercialization of product, in order to spot check of quality and supervision.
Invention fourth key point: as health care product, by tea seed cake and/or tea Pu with fine powder form or with suitably common capsule form
It is orally ingested, i.e., preferred tea Pu dosage is 5-12 grams/day;Tea seed cake is 0.5-4 grams/day.It is this have method be it is beneficial, being capable of antioxygen
Change, is antibacterial, antiviral, improving immunity;Whitening is promoted longevity.There is protective effect to enteron aisle simultaneously, prevents enteron aisle diarrhea.
The five of invention main points: as natural food-preservative and antioxidant in use, by tea seed cake and/or tea Pu with fine powder
Form is added in oxidizable putrefactive raw-food material in the ratio of 0.1-10%, can effectively extend the shelf-life of product
And freshness.
Supplementary explanation: the plan after patent application, inventor intend to be first to file patent protection, it is rear report product certification or
Submitting a report asking for be included in allows using catalogue.Patent of invention is to push and promote the progress of entire science and technology, there is certain perspective and neck
Elder generation's property, the product invented, it is possible to temporarily also acquire state approval or be included in permission catalogue;This is to be understood that completely
's.
It applies for a patent after obtaining first trial qualification or license, it, can be actively quasi- under the premise of having certain rights protection
Product certification is declared by standby items data and report, Xiang Youguan administrative service division.
Invention brief summary: inventor understands life by reading a large amount of academic documents and Patent data, inventor's science dialectically
Dose-effect relationship between active substances scientifically recognizes tea seed cake tea Pu, the naturally occurring effective work of institute in both raw materials
Sexual element, such as tea tannin (i.e. procyanidine), tea polyphenols and Tea Saponin, to the dosage efficacy profile of human body, security compliance
The two-phase Dosg-response Model of Hormesis theory;In grasping product between active ingredient concentration, dosage and effect three
Logical relation, to scientifically and rationally set product dosage.Unexpected and reasonable, solve tea seed cake tea Pu Gaoxiao
The problem utilized, and achieve the purpose that it is convenient for production, using safe, effect reliable, convenience and high-efficiency;And good economy can be obtained
Benefit and social benefit.
Technical effect (one): using this method, and production is simple, easy to use, pollution-free zero-emission, raw material all of,
Production cost is low, raw material sources are extensive;Tea seed cake tea Pu obtains efficiently utilizing comprehensively, there is obvious ecological benefits and economic benefit.
Technical effect (two): the invention production product can the much more expensive extract food additives of part fictitious hosts,
Or substantially reduce the use of synthesis class antioxidant.
Technical effect (three): tea seed cake tea Pu powder has natural anti-oxidation, food quality is improved, the effect of extending the shelf life;
There is convergence to enteron aisle simultaneously, promote intestinal health;There is antibacterial growth promotion simultaneously, immunocompetence and resistance can be enhanced;
Internal oxidation resistance is improved, physical strength is improved.
Technical effect (four): using this environmental protective hygienic product of tea seed cake tea Pu, has anti-aging, disease-resistant, enhancing anti-cancer
The effect of ability, promotion health.Also there are some skin-protecting functions such as including beauty face-whitening-nourishing.
Specific embodiment:
It is divided into production example (1--2) and Application Example (3-4).
More fully understand technical thought and technical solution of the invention for convenience, now by specific embodiment do introduction and
Analysis.
Embodiment one (tea seed cake food-grade):
Changshan County, Zhejiang Province tea seed cake powder is purchased, mechanicalness crushing is had been subjected to, granularity is 100 mesh or so.
Inspection is sampled, the content of Tea Saponin and tannin in testing product, result is Tea Saponin 15.3%, tannin 1.6%
Product packing, sticks food-grade label, and be labeled as natural, is added in an amount of the 0.2- of raw-food material
5%.
Embodiment two (tea Pu health care grade):
It purchases Zhejiang Province Kaihua County oil tea pericarp (tea Pu)
Jiangsu granary enterprise is asked to pulverize purchased tea Pu, granularity is up to 300 mesh or so.
Inspection is sampled, the content of tea tannin and Tea Saponin in testing product, result is tea tannin 8.6%, Tea Saponin
3.8%.
Product packing, sticks health care grade label, and being labeled as dosage is daily 2-12 grams.
Embodiment three takes six bowls, is respectively put into 200 milliliters of water, and two bowls are one group, is divided into three groups.
First group, every bowl is put into product made from embodiment 1 and takes 3 grams (T1 groups);Second group, every bowl is put into the system of embodiment 2
The product obtained takes 1 gram (T2 group);Third group does not let alone what product (T3 group).The albumen of one cooked egg is divided into six parts,
One piece is taken to immerse in each bowl respectively;It takes out and is placed at room temperature for three days in summer in July.
As a result, it has been found that: the albumen in four bowls of two test groups is that color is deepened, and any worm does not occur
Maggot;And T3 control group has obviously tiny worm maggot nearly ten, color is very deep, and very smelly;Illustrate that two products all have
Good antioxidation.
Example IV (tea Pu health care grade):
Pan, male, 65 years old, constitution was weaker;It is secondary by taking daily by product made from embodiment 2, one gram of use every time
Method is swallowed after being stirred with warm water;Side is continuous using after 20 days, and feeling energy and physical strength are improved.
Embodiments described above is exemplary embodiments of the invention, can not cover whole possibility embodiments.
Based on the embodiments of the present invention and directly apparent enlightenment, those skilled in the art are not making creative work premise
Under, every other embodiment obtained, such as the purposes of tea Pu or tea seed cake mutually exchanged or tea seed cake and tea Pu are mixed into tea
Fine powder, or add general food grade or health care grade excipient to be diluted or change dosage form in pulvis above-mentioned, while to final
Effective additive amount of product is exactly equivalent or equivalent simple alternative by the technical solution that corresponding dilution ratio is adjusted
Formula shall fall within the protection scope of the present invention.
The scope of the present invention not only includes the behavior for producing and selling the tea seed cake tea Pu of food-grade and/or health care grade,
It simultaneously also include that tea seed cake tea Pu is directly or indirectly used for food, when raw material or the usage behavior of finished product in health care product;Do not having
Under inventor's authorization conditions, by technical thought and technical solution of the invention, mainly 2 points, i.e., directly use and appropriate dosage
It uses;Tea seed cake tea Pu is directly or indirectly used for food and any of health care product uses unit, is regarded as invading this patent power.
Claims (10)
1. tea seed cake tea Pu is directly used in application method in food, feature in: first by tea seed cake and/or tea Pu, after impurity elimination is dry, object
Reason is ground into 80-120 mesh;Then active ingredient therein is detected, the active ingredient includes Tea Saponin, tea polyphenols, tea tannin
Or procyanidine;Directly or add auxiliary material that product is made up to product or caffein powder.
2. according to claim 1, feature in: the dosage of tea seed cake, tea Pu or caffein powder is food by weight percentage
The 0.1-10% of raw material.
3. according to claim 2, feature in: the preferable amount of tea seed cake, tea Pu or caffein powder is by weight percentage
The 05-5% of raw-food material.
4. tea seed cake tea Pu is directly used in application method in health care product, feature in: first by tea seed cake and/or tea Pu, after impurity elimination is dry,
Physical crushing is 300 mesh at 120 mesh or ultra-fine grinding;Then active ingredient therein is detected;Directly or add auxiliary material that product is made
Up to product or caffein powder;The active ingredient includes tea soap rope, tea polyphenols, tea tannin or procyanidine.
5. according to claim 4, feature is taken in the dosage of tea seed cake, tea Pu or caffein powder with tea tannin or tea polyphenols
Amount calculates, and is being no more than 100mg/kg (weight)/day;It is calculated with the intake of Tea Saponin, is no more than 20mg/kg (weight)/day.
6. according to claim 5, feature is in the preferable amount of tea seed cake, tea Pu or caffein powder, with tea tannin or tea polyphenols
Intake is calculated as 10-20mg/kg (weight)/day;1-4mg/kg (weight)/day is calculated as with the intake of Tea Saponin.
7. according to claim 4, preferably tea Pu dosage is 5-12 grams/day.
8. according to claim 4, preferably tea seed cake dosage is 0.8-3.2 grams/day;
9. according to claim 5, preferably caffein powder dosage is 1-10 grams/day.
10. according to claim 1,2,3,4,5,6 and 9, the caffein powder is that tea seed cake and tea Pu mix the resulting pulvis of addition and produce
Product.
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Cited By (1)
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CN114213474A (en) * | 2021-12-15 | 2022-03-22 | 山东农业工程学院 | Acorn tannin extraction method |
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CN114213474A (en) * | 2021-12-15 | 2022-03-22 | 山东农业工程学院 | Acorn tannin extraction method |
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