CN109418276A - A kind of sterilization single dose - Google Patents
A kind of sterilization single dose Download PDFInfo
- Publication number
- CN109418276A CN109418276A CN201710788563.5A CN201710788563A CN109418276A CN 109418276 A CN109418276 A CN 109418276A CN 201710788563 A CN201710788563 A CN 201710788563A CN 109418276 A CN109418276 A CN 109418276A
- Authority
- CN
- China
- Prior art keywords
- single dose
- hymexazol
- sterilization
- finished product
- follows
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 19
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 19
- KGVPNLBXJKTABS-UHFFFAOYSA-N hymexazol Chemical compound CC1=CC(O)=NO1 KGVPNLBXJKTABS-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000005794 Hymexazol Substances 0.000 claims abstract description 29
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 28
- 239000003814 drug Substances 0.000 claims abstract description 24
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000002360 preparation method Methods 0.000 claims abstract description 20
- 238000009472 formulation Methods 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 18
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 14
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 14
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 13
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 8
- 229920002472 Starch Polymers 0.000 claims abstract description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 7
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims abstract description 7
- 239000000741 silica gel Substances 0.000 claims abstract description 7
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 7
- 239000008107 starch Substances 0.000 claims abstract description 7
- 235000019698 starch Nutrition 0.000 claims abstract description 7
- 101000989653 Homo sapiens Membrane frizzled-related protein Proteins 0.000 claims abstract description 6
- 102100029357 Membrane frizzled-related protein Human genes 0.000 claims abstract description 6
- 239000002253 acid Substances 0.000 claims abstract description 6
- 239000006229 carbon black Substances 0.000 claims abstract description 6
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 6
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 5
- 239000001110 calcium chloride Substances 0.000 claims abstract description 5
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims description 13
- 238000003672 processing method Methods 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 7
- 239000012752 auxiliary agent Substances 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 6
- 238000011049 filling Methods 0.000 claims description 5
- 239000002689 soil Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 238000001125 extrusion Methods 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 239000003610 charcoal Substances 0.000 claims 1
- 238000005660 chlorination reaction Methods 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 16
- 235000009566 rice Nutrition 0.000 abstract description 16
- 241000918585 Pythium aphanidermatum Species 0.000 abstract description 5
- 244000241257 Cucumis melo Species 0.000 abstract description 3
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 abstract description 3
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 abstract description 3
- 239000000440 bentonite Substances 0.000 abstract description 3
- 229910000278 bentonite Inorganic materials 0.000 abstract description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 abstract description 3
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- 235000013311 vegetables Nutrition 0.000 abstract description 3
- 244000131316 Panax pseudoginseng Species 0.000 abstract description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 abstract description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 abstract description 2
- 235000008434 ginseng Nutrition 0.000 abstract description 2
- 240000007594 Oryza sativa Species 0.000 abstract 1
- 241000209094 Oryza Species 0.000 description 16
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000000575 pesticide Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000002245 particle Substances 0.000 description 7
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 6
- 230000000857 drug effect Effects 0.000 description 5
- 239000000417 fungicide Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000000428 dust Substances 0.000 description 4
- 230000000855 fungicidal effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000004563 wettable powder Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000005807 Metalaxyl Substances 0.000 description 2
- 239000005843 Thiram Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- ZQEIXNIJLIKNTD-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate Chemical compound COCC(=O)N(C(C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000008177 pharmaceutical agent Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- KUAZQDVKQLNFPE-UHFFFAOYSA-N thiram Chemical compound CN(C)C(=S)SSC(=S)N(C)C KUAZQDVKQLNFPE-UHFFFAOYSA-N 0.000 description 2
- 229960002447 thiram Drugs 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 231100000674 Phytotoxicity Toxicity 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- -1 have aqua Substances 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- ANGDWNBGPBMQHW-UHFFFAOYSA-N methyl cyanoacetate Chemical compound COC(=O)CC#N ANGDWNBGPBMQHW-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000011882 ultra-fine particle Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a kind of sterilization single doses, and wherein hymexazol raw medicine 30%-90%, white carbon black 4%-5%, neopelex 2%-5%, NNO2%-4%, sodium bicarbonate 2%-5%, starch 0%-10%, bentonite supply surplus；Preparation formulation is water dispersible granules；Or hymexazol raw medicine 10%-40%, calcium chloride 3%-5%, sodium lignin sulfonate 3%-5%, sodium carboxymethylcellulose 2%-5%, polymethylacrylic acid receive 2%, allyl alcohol polyethenoxy ether 0.5%, magnesium stearate 0.5%, sodium bicarbonate 19%-25%, citric acid 26%-35%, superfine silica gel powder and supply surplus；Preparation formulation is effervescent.It is mainly used for preventing and treating rice seedling damping-off, the seedling blights such as various vegetables, melon and fruit, ginseng, root rot, samping off can also be prevented and treated.
Description
Technical field
The invention belongs to soil fungicides fields, relate generally to a kind of sterilization single dose, for preventing and treating rice seedling damping-off,
Also there is certain control efficiency to the seedling blights such as vegetables, melon and fruit, ginseng, root rot, samping off.
Background technique
Rice is China the first generalized grain crop, but generally existing seedling quality is poor in each rice region production in the whole nation at present
Problem, be mainly shown as disease seedling, weak seedling.The maximum that especially dry rice seedling damping-off becomes dry-raising and sparse-planting technology in recent years hinders
Hinder, normal condition disease incidence 15% or so, because of the cause of weather, management etc., crushing also shoe of falling ill is shown in not fresh.The disease
Evil is to cause the disease resistance of rice shoot to reduce, thus by sickle-like bacteria, miliary damping-off due to being influenced by the factor of a variety of adverse environments
Bacterium etc. take advantage of a weak point in opponent's defence invade sprout term disease extremely.
The main reason for rice seedling blight threatens biggish Major Diseases during being seedling, fall ill is that temperature is too low, warm
Excessive, the soil meta-alkali of difference, illumination deficiency rice shoot are thin and delicate, kind is measured the factors such as excessive and led to caused by the infecting of pathomycete in soil.
It is withered per rice shoot after thering is different degrees of generation, field symptom to be mainly shown as emergence every year, it is easy to pull off, basal part of stem rots,
There is rotten pears taste, heavier full wafer of falling ill is dead, and how long diseased plant base portion has redness of the skin or complexion mustiness object.Slightly keep seedling growth weak,
Root of hair is slow, and severe generation rice shoot is withered and yellow lethal, causes rice shoot insufficient, misses the farming season, influence rice yield.
Agriculturally, the major pharmaceutical agent currently used for preventing and treating rice seedling blight have hymexazol, metalaxyl, thiram single dose and
Compound preparation, with the use of many years, the resistance of preparation occur it is obvious year by year, the formulations of pesticide mainly have aqua, wettable powder,
Missible oil causes serious pollution and harm to environment and personnel because dosage form is containing benzene and dust.Because preparation formulation cannot change
Bad to preparation assimilation effect into crop, drug effect is low and not lasting.Therefore extremely urgent, this hair is improved to existing fungicide
It is bright researched and developed it is a kind of it is resistance, without benzene, without dust, no pollution to the environment, to the fungicide of personnel safety.
Summary of the invention
The present invention provides a kind of sterilization single doses, it is characterised in that: feed components weight percent are as follows: hymexazol raw medicine
30%-90%, white carbon black 4%-5%, neopelex 2%-5%, NNO2%-4%, sodium bicarbonate 2%-5%,
Starch 0%-10%, bentonite supply surplus；Preparation formulation is water dispersible granules.
A kind of sterilization single dose, it is characterised in that: feed components weight percent are as follows: hymexazol raw medicine 10%-40%, chlorine
Change calcium 3%-5%, sodium lignin sulfonate 3%-5%, sodium carboxymethylcellulose 2%-5%, polymethylacrylic acid receive 2%, allyl
Alcohol polyoxyethylene ether 0.5%, magnesium stearate 0.5%, sodium bicarbonate 19%-25%, citric acid 26%-35%, superfine silica gel powder are mended
Sufficient surplus；Preparation formulation is effervescent.
It can be used for preventing and treating rice seedling damping-off, also have good control efficiency to various vegetables, melon and fruit wilt disease.
The weight percent content water dispersible granules more preferable 80% of hymexazol in the single dose, effervescent is more excellent
Select 20%.
The invention technical problem to be solved is as follows:
1, the major pharmaceutical agent at this stage for preventing and treating rice seedling blight has hymexazol, metalaxyl, thiram single dose and compounding
Preparation, after many years use, the resistance of preparation occurs obvious year by year；Peasant's drug cost is high.
2, general fungicide dosage form is aqua, wettable powder, missible oil dosage form, and above-mentioned dosage form is containing benzene and dust,
Serious pollution and harm are caused to environment and personnel.
3, existing preparation formulation cannot improve, and crop is bad to preparation assimilation effect, and drug effect is low and not lasting.
The technical solution adopted by the invention is as follows:
Feed components weight percent are as follows: hymexazol raw medicine 30%-90%, white carbon black 4%-5%, detergent alkylate sulphur
Sour sodium 2%-5%, NNO2%-4%, sodium bicarbonate 2%-5%, starch 0%-10%, bentonite supply surplus；Preparation formulation is
Water dispersible granules.
The more preferable scheme of the sterilization single dose are as follows: feed components weight percent are as follows: hymexazol raw medicine 80%, white carbon black
5%, neopelex 4%, NNO2%, sodium bicarbonate 2%, starch 7%；Preparation formulation is water dispersible granules.
Sterilize single dose processing method the following steps are included:
1. hymexazol raw medicine is accurately weighed in proportion with auxiliary agent, it is uniformly mixed；
2. the raw material is crushed, puddle again；
3. after the completion of puddling, extrusion granulation being carried out after air-flow crushing, is made into finished product；
4. starting bottle placer, filling weight and speed are adjusted, qualified finished product is packed；
5. testing, being put in storage to the finished product after the completion of packaging；
The step 1. described in raw material weigh after incorporation time be 1h.
The step 2. in raw material smashing fineness control more than 325 mesh, puddle the time be 30min
Feed components weight percent are as follows: hymexazol raw medicine 10%-40%, calcium chloride 3%-5%, sodium lignin sulfonate
3%-5%, sodium carboxymethylcellulose 2%-5%, polymethylacrylic acid receive 2%, allyl alcohol polyethenoxy ether 0.5%, stearic acid
Magnesium 0.5%, sodium bicarbonate 19%-25%, citric acid 26%-35%, superfine silica gel powder supply surplus；Preparation formulation is effervescence granular
Agent.
The more preferable scheme of the sterilization single dose are as follows: feed components weight percent are as follows: hymexazol raw medicine 20%, calcium chloride
5%, sodium lignin sulfonate 5%, sodium carboxymethylcellulose 5%, polymethylacrylic acid receive 2%, allyl alcohol polyethenoxy ether
0.5%, magnesium stearate 0.5%, sodium bicarbonate 22%, citric acid 30%, superfine silica gel powder supply surplus；Preparation formulation is effervesce
Granule.
Sterilize single dose processing method the following steps are included:
1. hymexazol raw medicine is accurately weighed in proportion with auxiliary agent, it is uniformly mixed；
2. the raw material is crushed, puddle again；
3. after the completion of puddling, being granulated, drying, it is made into finished product；
4. starting bottle placer, filling weight and speed are adjusted, qualified finished product is packed；
5. testing, being put in storage to the finished product after the completion of packaging；
The step 1. described in raw material weigh after incorporation time be 1h.
The step 2. in raw material smashing fineness control more than 325 mesh, puddle the time be 30min
Compared with prior art, the invention has the following advantages:
In terms of drug effect, 80% hymexazol water dispersible granules 2013,2 years 2014 through agriculture chemical examination institution, Jilin Province, black
The field examination at station, Plant Protection Inst., Jiangsu Academy of Agriculture, Liaoning Province agriculture chemical examination station is examined and determine in the pesticide management of Longjiang province
Test and show: with 1-1.4 grams/m (commodity amount), seedbed sprinkling, average preventive effect is 85% or more.Rice plant there are no
Phytotoxicity effect, has no adverse effects to growth and development, the yield etc. of rice.
In terms of dosage form, the used water-dispersible granules of the present invention and effervescent, water-dispersible granules are by 80%
After hymexazol water dispersible granules stir into the water, equably it can dissolve and be dispersed in water, therefore, it has wettable powder
The characteristics of agent and emulsion.With the Analysis of Physical of dosage form, water-dispersible granules are most superiority in the current formulations of pesticide
With a kind of novel form of competitiveness.Effervescent is a kind of pesticides new formulation, and there is unique superiority to meet the formulations of pesticide
Development trend.The raw medicine of pesticide is become ultrafine particle by the dissolution of organic solvent, utilizes special producing technique adjustment agriculture
Particle is made on the basis of not changing raw medicine characteristic in the pH value of medicine, and rapid bubbling is decomposed after powder touches water, release
Bulk gas out, raw medicine are disintegrated rapidly in this orientation reaction by the motive force of gas, and effective component rapid dispersion, distribution is more
Uniformly, drug is more quick-acting, and drug effect can give full play to.
80% hymexazol water dispersible granules also show following several spies other than having the characteristics that general granula
Point:
(1) there is no dust from flying, reduce the pollution to environment, to operator's safety, and toxic articles kind can be made low
Poison.
(2) compared with wettable powder and suspending agent, active constituent content is high, and product is relatively denser, small in size, is convenient for
Packaging, storage and transport.
(3) storage stability and physical and chemical stability are preferable, and especially to pesticide unstable in water, this agent is made
Type is got well than suspending agent.
(4) disintegration rate of particle is fast, and particle one touches water and can be wet immediately, and collapses rapidly during sinking under the water
Solution.
(5) after particle is disintegrated in water, it is dispersed into minimum particle quickly and is sieved wet after disintegration agitation through 325 mesh,
Residue is not more than 0.3% on sieve.
(6) suspension stability is preferable, is not finished on the day of prepared medical fluid, and second day agitated to suspend again,
Do not influence drug effect.
(7) particle of dispersion in a liquid, which only need to slightly stir tiny particle, to be well dispersed in liquid, directly
Uniformity is able to maintain to liquid medicine jet is complete.
Detailed description of the invention
Fig. 1 is process flow chart of the invention.
Specific embodiment
Technical solution of the present invention is described in detail below in conjunction with attached drawing:
1. main component brief introduction
Hymexazol
ISO adopted name: hymexazol；
Product name: hydroxyisoxazole stands withered spirit, the mould spirit of suppression；
Pesticide classification: fungicide；
Chemical classification: heterocyclic compound；
Chemical name: -5 methylisoxazole of 3- hydroxyl；
Structural formula
Molecular formula: C4H5NO2；
Relative molecular mass: 99.09 (by international relative atomic masses in 1991)；
Bioactivity: sterilization；
Fusing point: 86-87 DEG C
Vapour pressure: < 133mPa (25 DEG C)
Solubility: water 80g/L (25 DEG C), acetone, methanol are easy dissolution in ethyl alcohol grade other organic solvents；
Stability: stable under alkaline conditions, it is quite stable in acidic environment, to light, thermostabilization.
2, process flow of the invention:
It is puddled 1. hymexazol raw medicine is accurately weighed in proportion with each auxiliary agent, puddles time control in 30min.
2. the raw material is crushed, smashing fineness is controlled more than 325 mesh, puddles 1h again.
3. after the completion of puddling, being granulated, drying, it is then made into finished product.
4. starting bottle placer, filling weight and speed are adjusted, qualified finished product is packed.
5. testing, being put in storage to the finished product after the completion of packaging.
3, product form (each component contained in product, including effective component, related impurities, synergist, bleeding agent, peace
Auxiliary agents title and the contents such as full agent, filler)
80% hymexazol water dispersible granules product form
| Components Name | Content | Main function in the product |
| Hymexazol | 80.0% | Effective component |
| White carbon black | 5% | It is moisture-proof |
| Neopelex | 4% | Wetting agent |
| NNO | 2% | Diffusant |
| Sodium bicarbonate | 2% | Disintegrating agent |
| Starch | 7% | Binder |
20% hymexazol effervescent product form
| Components Name | Content | Main function in the product |
| Hymexazol | 20.0% | Effective component |
| Calcium chloride | 5% | Desiccant |
| Sodium lignin sulfonate | 5% | Dispersing agent |
| Sodium carboxymethylcellulose | 5% | Binder |
| Polymethylacrylic acid is received | 2% | Binder |
| Allyl alcohol polyethenoxy ether | 0.5% | Nonionic surfactant |
| Magnesium stearate | 0.5% | Lubricant |
| Sodium bicarbonate | 22% | Disintegrating agent |
| Citric acid | 30% | Disintegrating agent |
| Superfine silica gel powder | Supply surplus | Filler |
Claims (10)
1. a kind of sterilization single dose, it is characterised in that: feed components weight percent are as follows: hymexazol raw medicine 30%-90%, hard charcoal
It is black 4%-5%, neopelex 2%-5%, NNO2%-4%, sodium bicarbonate 2%-5%, starch 0%-10%, swollen
Profit soil supplies surplus；Preparation formulation is water dispersible granules.
2. sterilization single dose as described in claim 1, it is characterised in that: the more preferable scheme of the sterilization single dose are as follows: feed components
Weight percent are as follows: hymexazol raw medicine 80%, white carbon black 5%, neopelex 4%, NNO2%, sodium bicarbonate 2%,
Starch 7%；Preparation formulation is water dispersible granules.
3. as described in claim 1 sterilization single dose, it is characterised in that: sterilization single dose processing method the following steps are included:
1. hymexazol raw medicine is accurately weighed in proportion with auxiliary agent, it is uniformly mixed；
2. the raw material is crushed, puddle again；
3. after the completion of puddling, extrusion granulation being carried out after air-flow crushing, is made into finished product；
4. starting bottle placer, filling weight and speed are adjusted, qualified finished product is packed；
5. testing, being put in storage to the finished product after the completion of packaging.
4. as claim 3 sterilize single dose processing method, it is characterised in that: the step 1. described in raw material weigh after mixing
Time is 1h.
5. as claim 3 sterilize single dose processing method, it is characterised in that: the step 2. in raw material smashing fineness control exist
More than 325 mesh, puddling the time is 30min.
6. a kind of sterilization single dose, it is characterised in that: feed components weight percent are as follows: hymexazol raw medicine 10%-40%, chlorination
Calcium 3%-5%, sodium lignin sulfonate 3%-5%, sodium carboxymethylcellulose 2%-5%, polymethylacrylic acid receive 2%, allyl alcohol
Polyoxyethylene ether 0.5%, magnesium stearate 0.5%, sodium bicarbonate 19%-25%, citric acid 26%-35%, superfine silica gel powder are supplied
Surplus；Preparation formulation is effervescent.
7. sterilization single dose as claimed in claim 6, it is characterised in that: the more preferable scheme of the sterilization single dose are as follows: feed components
Weight percent are as follows: hymexazol raw medicine 20%, calcium chloride 5%, sodium lignin sulfonate 5%, sodium carboxymethylcellulose 5%, poly- first
Base acrylic acid receives 2%, allyl alcohol polyethenoxy ether 0.5%, magnesium stearate 0.5%, sodium bicarbonate 22%, citric acid 30%, micro-
Powder silica gel supplies surplus；Preparation formulation is effervescent.
8. as claimed in claim 6 sterilization single dose, it is characterised in that: sterilization single dose processing method the following steps are included:
1. hymexazol raw medicine is accurately weighed in proportion with auxiliary agent, it is uniformly mixed；
2. the raw material is crushed, puddle again；
3. after the completion of puddling, being granulated, drying, it is made into finished product；
4. starting bottle placer, filling weight and speed are adjusted, qualified finished product is packed；
5. testing, being put in storage to the finished product after the completion of packaging.
9. as claim 8 sterilize single dose processing method, it is characterised in that: the step 1. described in raw material weigh after mixing
Time is 1h.
10. as claim 8 sterilize single dose processing method, it is characterised in that: the step 2. in raw material smashing fineness control
More than 325 mesh, puddling the time is 30min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710788563.5A CN109418276A (en) | 2017-08-23 | 2017-08-23 | A kind of sterilization single dose |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710788563.5A CN109418276A (en) | 2017-08-23 | 2017-08-23 | A kind of sterilization single dose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109418276A true CN109418276A (en) | 2019-03-05 |
Family
ID=65513884
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|---|---|---|---|
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| Country | Link |
|---|---|
| CN (1) | CN109418276A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112961527A (en) * | 2019-12-13 | 2021-06-15 | 徐州诺特化工有限公司 | Processing technology of metaldehyde and melamine modified urea-formaldehyde glue compounded ship body protective agent |
-
2017
- 2017-08-23 CN CN201710788563.5A patent/CN109418276A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112961527A (en) * | 2019-12-13 | 2021-06-15 | 徐州诺特化工有限公司 | Processing technology of metaldehyde and melamine modified urea-formaldehyde glue compounded ship body protective agent |
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Application publication date: 20190305 |