CN1094052C - Anticancer goose blood preparation - Google Patents
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- CN1094052C CN1094052C CN98121673A CN98121673A CN1094052C CN 1094052 C CN1094052 C CN 1094052C CN 98121673 A CN98121673 A CN 98121673A CN 98121673 A CN98121673 A CN 98121673A CN 1094052 C CN1094052 C CN 1094052C
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Abstract
The present invention relates to anticancer goose blood preparation-goose serum preparation and/or goose blood cell preparation, which uses fresh goose blood as raw materials so as to separate serum and blood cells. Oral liquid is prepared from the preparation comprising the serum, honey liquid and royal jelly; by scientific processing, goose blood sheets are prepared by drying, pulverizing, seiving the blood cells and mixing with Chinese yam, bletilla tuber, fructus aurantii, corydalis tuber and zedoary of chosen traditional Chinese medicine. The present invention has the advantages of unique prescriptions and conspicuous tumour repression, relieves toxic side effects of chemotherapy and radiotherapy for hosts, improves the immunity capability of organism erythrocyte and lymphocyte, prolongs life time, performs good adjuvant therapy functions of diseases, such as malignant tumors, the canker of a digestive system, atrophic gastritis, and performs a certain function of cancer prevention. The present invention has the maximum characteristic that the anticancer goose blood preparation-goose serum preparation and/or goose blood cell preparation is demonstrated by system experimental research and clinical application.
Description
The present invention relates to a kind of anticancer preparation, specifically be respectively the goose serum preparation that primary raw material is made, Sanguis Anseris domestica cell preparation with the isolating serum of fresh goose blood, hemocyte.
As everyone knows, malignant tumor is the common disease of serious threat human life health, a universally acknowledged difficult problem, and in improving, the late tumor symptom, prolong life cycle and be current in, one of doctor trained in Western medicine tumor therapeutics important topic, at present both at home and abroad from animal, seek new anticancer method in the plant, composition more and more is subjected to people's attention, and one of them important source master is anticancer animals and plants among the people.Beg till the present the main Therapeutic Method of malignant tumor and be perform the operation, put, chemotherapy.Find in the clinical practice during " three is big " treatment or after the treatment a kind of auxiliary treatment preparation that can anticancerly can set upright again press for, yet this to have a two-way function preparation less, though have, therapeutic effect is not very good yet.
The present invention is probing boldly, and conscientiously screening produces on Lun Zheng the basis repeatedly.
The object of the present invention is to provide a kind of comprehensive utilization Sanguis Anseris domestica, have malignant neoplasm, the anticancer digestive ulcer of setting upright, chronic diseases such as atrophic gastritis have the Sanguis Anseris domestica preparation of auxiliary treatment.
Solution of the present invention is used modern laboratory facilities and clinical observation based on the argumentation of the medical at all times monograph of motherland's medical science to Sanguis Anseris domestica, through master of medical science's problem, economizes the special research of nature fund problem and finishes.
Find in the experiment that mainly there is the serum part in the anticancer goose blood active ingredient, cultivate through cancer cell in vitro, zoopery, a small amount of clinical observation, SR (mouse breast cancer), S180 (sarcoma 180), Ehrlichascites cell (ehrlich carcinoma) all there are the obvious tumor effect that presses down, compare (P＜0.05) with matched group.To advanced liver cancer, patients clinicals such as colon cancer are used, and anticancer to set upright effect obvious, and the digestive ulcer atrophic gastritis is had obvious adjuvant treatment effect.The present invention's anticancer goose blood preparation is: with the isolating goose serum preparation of Sanguis Anseris domestica, and/or isolating Sanguis Anseris domestica cell preparation.It can be said dosage form on any materia medica.Wherein goose serum can be helped with honey liquor, Lac regis apis is done seasoning, antibacterial, strengthen nutrition, lubricious easy clothes, and its active anticancer component played the nourishing effect, isolating Sanguis Anseris domestica cell and the experiment of solid composition show that the made rat stomach intestinal mucosal injury of acetic acid is had obvious repair, and the metabolite that in intestinal, decomposes promotion gastrointestinal peristalsis, get rid of intravital harmful substance, be commonly called as abluent in the body.Be equipped with selected Rhizoma Dioscoreae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Aurantii, Rhizoma Curcumae, Rhizoma Corydalis and make tablet, have the merit of potentiation such as nourishing the stomach to promote the production of body fluid, promoting the circulation of QI to relieve pain, antiulcer, antitumor.
The volume of goose serum oral liquid primary raw material consists of:
And satisfying the each component sum is 100%
The optimal volume of goose serum oral liquid primary raw material consists of:
Goose serum 65%
Lac regis apis 5%
The weight of Sanguis Anseris domestica cell sheet primary raw material consists of:
10～20 parts of 20～35 portions of Rhizoma Dioscoreaes of Sanguis Anseris domestica cell xeraphium
5～15 parts of 10～15 parts of Fructus Aurantiis of the Pseudobulbus Bletillae (Rhizoma Bletillae)
10～20 parts of 10～20 parts of Rhizoma Corydalis of Rhizoma Curcumae
The optimum weight of Sanguis Anseris domestica sheet primary raw material consists of:
15 parts of 25 portions of Rhizoma Dioscoreaes of Sanguis Anseris domestica cell xeraphium
10 parts of 15 parts of Fructus Aurantiis of the Pseudobulbus Bletillae (Rhizoma Bletillae)
10 parts of 10 parts of Rhizoma Corydalis of Rhizoma Curcumae
The cowherb hemocyte refers to that goose is red, white, platelet cell and solid composition
The production method of anticancer goose blood preparation is: 1, blood sampling: can divide artificial live body wing vein thing bacterium blood collection method and machine to put to death blood collection method, experimental data shows; Body weight is young goose more than 3Kg, can adopt 2-3 time in every month, and can strengthen anticarcinogenic effect by scientific feeding; Serum behind the hemocyte natural coagulation in bulk, places sterile chamber respectively after filtration;
2, get Mel, add its etc. 2 times of sterile distilled waters of appearance put 85～95 ℃ of calorstat half an hour, filter while hot and be chilled to below 10 ℃; Royal jelly extracting is put colloid mill and is ground in addition, filters, and gets ethylparaben again, with the ethyl ester dissolving, adds water to 100ml.Stir well, concentration is 0.1%;
3, goose serum, honey liquor, Lac regis apis, ethylparaben are sneaked into stirred vessel, stir well fill, every 5～10ml both can get oral liquid, adopted the ultraviolet irradiation sterilization, cryopreservation.
4, get the Sanguis Anseris domestica cell clot,, be ground into 120 fineness-15 ℃ of following lyophilizations, get the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Dioscoreae, Fructus Aurantii, Rhizoma Corydalis, Rhizoma Curcumae again and insert in the multi-function extractor, decoct the 1st time 2 hours 2 times, the 2nd time 1 hour, remove medicinal residues, get decocting liquid, being concentrated into relative density is 1.30 (20 ℃), adding ethanol to the alcohol amount of containing and be 70% leaves standstill, get supernatant and reclaim ethanol, being concentrated into relative density is the thick paste of 1.33 (20 ℃), preserves with aseptic device;
5, with Sanguis Anseris domestica cell xeraphium, medicine thick paste, 10% starch slurry are made granule after being mixed and sparing, and insert drying baker 2 hours, and control moisture with 14 mesh sieve granulate, adds an amount of magnesium stearate about 3.5%, be pressed into special-shaped sheet, and the bag film-coat can become the Sanguis Anseris domestica sheet.
Prescription design features of the present invention is: anticancer, goose serum is set upright, Mel, Lac regis apis; Remove harmful substance in the body, Sanguis Anseris domestica cell (title of organism abluent); Circulation of qi promoting, pain relieving, hemostasis, anticancer, antiulcer are with cleaning Chinese medicine; Have following advantage:
1, overcome sent out that tradition drink raw that the whole blood method exists easy pollution, cannot say for sure to deposit, the fraud of instructions about how to take medicine difficulty, the no course of treatment, dosage and traditional method easily to the patient mislead, the shortcoming of the difficult branch of primary and secondary.
2, the present invention tries hard to protect in the raw material active anticancer component not to be damaged in preparation process, and is fewer but better, easily clothes, easily absorb.
3, to select the homologous natural animal-plant medicine of medicated diet for use be raw material in the present invention, promptly anticancerly sets upright again, nontoxic to human body, meets national pharmaceutical control law, the food hygiene law regulation.
4, with interleukin II, the contrast of lentinan product, experimental data proof anticarcinogenic effect all excellent it (P＜0.05).
5, the present invention is to digestive ulcer, and chronic diseases such as atrophic gastritis have remarkable therapeutical effect.
6, experimental data shows that the present invention has certain protective effect on cancer risk to experimental mouse.
The production technology figure of Fig. 1 anticancer goose blood preparation
Fig. 2 tests 1 coordinate figure
Fig. 3 tests 2 coordinate figure
Fig. 4 tests 3 coordinate figure
Fig. 5 tests 4 coordinate figure
Fig. 6 tests 5 coordinate figure
Fig. 7 tests 6 coordinate figure
Fig. 8 tests 7 coordinate figure
Fig. 9 tests 8 coordinate figure
Embodiment
Press following proportioning raw material:
Oral liquid (being as the criterion) by 100: goose serum 650ml, Mel 100 grams, Lac regis apis 50 grams, sterile distilled water 280ml, to hydroxyl Ethyl formate 0.5 gram.
Tablet (being as the criterion by 1000): Sanguis Anseris domestica cell xeraphium 500 restrains, Rhizoma Dioscoreae 300 restrains, the Pseudobulbus Bletillae (Rhizoma Bletillae) 300 restrains, Fructus Aurantii 200 restrains, Rhizoma Corydalis 200 restrains, Rhizoma Curcumae 200 restrains, starch 60 restrains, magnesium stearate is an amount of.
Production method is as follows:
Separate goose serum earlier, hemocyte is concentrated sterile chamber respectively, and wherein serum is through filtering.Get Mel, add sterile distilled water and put 85～95 ℃ of calorstat half an hour, filter while hot, filtrate is chilled to below 10 ℃; Royal jelly extracting is put colloid mill and is ground in addition, filters; Get ethylparaben again; Use 75% dissolve with ethanol.Add sterile distilled water to 100ml, stir well, concentration is 0.1%; Goose serum, honey liquor, Lac regis apis, ethylparaben are sneaked into stirred vessel, stir well fill, every 10ml both can get oral liquid, adopted ultraviolet irradiation sterilization, cryopreservation.The hemocyte grumeleuse-15 ℃ of following lyophilizations, is ground into 120 order fineness in addition; Getting Rhizoma Dioscoreae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Aurantii, Rhizoma Corydalis, Rhizoma Curcumae again inserts in the multi-function extractor, decoct 2 times, the 1st time 2 hours, the 2nd time 1 hour, remove medicinal residues, getting decocting liquid, being concentrated into relative density is 1.30 (20 ℃), adding ethanol is 70% to leave standstill to containing alcohol, get supernatant and reclaim ethanol, being concentrated into relative density is the thick paste of 1.33 (20 ℃), preserves with sterile chamber.With Sanguis Anseris domestica cell xeraphium, medicine thick paste, 10% starch slurry are made granule after being mixed and sparing, and insert 70 ℃ of dryings of drying baker 24 hours, control moisture with 14 mesh sieve granulate, adds an amount of magnesium stearate about 3.5%, be pressed into special-shaped sheet, the bag film-coat, again the packing the Sanguis Anseris domestica sheet.
The inventor suppresses serial experiment by goose serum to mice ehrlich carcinoma propagation, has verified the goose serum anticancer effect, experimental technique, and process, result are as follows:
9 of materials and methods blood supply geese, available from Hubei province, body weight 2.5～5Kg, 5 male 4 is female; Medicine: normal saline is a Wuhan Bin Hu pharmaceutical factory product, lot number 970107; Interleukin II; Fourth Ring, Beijing bioengineering product factory produces, lot number: 970311; Calf serum: Sino-German three sharp biological factory productions, lot number 97041; The tumor strain: the mice ehrlich carcinoma is available from the institute of oncology, Hubei Province; Animal: kunming mice is available from Hubei Province's medical science animal center; Method: at goose wing vein place routine disinfection, take a blood sample with the asepsis injector row vein, its amount is decided according to treatment group Mus number, and general each about 5～10ML slowly injects sterile test tube with Sanguis Anseris domestica along wall at the other aseptic area of alcohol burner flame, tight with capping plug, inserted 37 ℃ of constant temperature water bath casees 1/2-1 hour, it is solidified, take out centrifugal (1500 rev/mins 5-10 minute), sucking-off goose serum in gnotobasis is injected by the capable mouse peritoneal of experiment required dosage again.The animal modeling: extract ehrlich ascites cell, adding normal saline is 1 * 10 in microscopically adjustment cancerous cell concentration
7/ mm
3, each group of 0.2ml inoculation mice is in second day begin treatment, controlled observation; The approach of giving: lumbar injection.
Observation index:
1, the body weight method is surveyed the degeneration of ascites cells propagation
1) establish the blank group and verify this method feasibility, accuracy, method is feasible as a result for it, can reflect cell proliferation trend substantially;
2) claim basic body weight earlier, weigh every day after 3-4 days;
3) by body weight mean curve plotting figure.
2, the funnel method is surveyed ascites volume
1) every dead all dissection in the experiment is inserted funnel and is made ascites flow into the scale test tube, calculates the accumulative total ascites volume,
2) if claiming to lack, ascites inhales with syringe;
3) place's meter is extremely counted ascites volume synchronously, X ± SD, T check
3, detect life cycle, observe and reverse phenomenon
4, life quality is observed, hair color, mobility, feces, drug reaction etc.
5, put to death thymus synchronously, spleen, liver claim weight in wet base, ascites cells concentration
For objectively respond goose serum can be anticancer with and tire, the mechanism of action reduces experimental error, special repeated experiments continuously 8 times, the result is as follows:
Observe mice Ehrlich ascites cell growth curve figure as seen with the body weight method, 8 crowdes of repeated experiments results are basic identical, goose serum (GBS) sets of curves is Comparatively speaking more smooth, generally in 5～8 days (minority was at 14 days) variant (P＜0.05), difference gradually strengthens later on, laboratory observation to 3～5 day just cancerous cell are bred the peak in vivo, and body weight is carrying out property increase (cancerous cell is index propagation) afterwards.What is interesting is and once use 2 groups of goose serums (GBS I II) though contrast individual variation, between group not obvious (P＞0.05), and trend is consistent gradually, shows repeatable strong.Goose serum (GBS) is compared obvious difference (P＜0.05) with blank group (control), normal saline (NS), shows with this method treatment and not treat its result completely different; Carried out three batches of contrasts with the interleukin II group, 2 batches of differential delay (P＜0.05) after 12 days have wherein been arranged, show the goose serum antitumaous effect than lastingly, and side effect has been little; Compare with calf serum (NBS), early stage cancer suppressing action more obvious (P＜0.05) shows that the goose serum antitumaous effect is non-to be " foreign preteins "; Have anticancer and dual-use function that set upright with lentinan Discrepancy Description goose serum; Repeated experiments can be known the anticancer goose blood composition by inference mainly in serum, and this is the foundation stone that continues research.
In 8 batches of repeated experiments, have 4 batches totally 5 mices phenomenon appears reversing through the GBS treatment, this phenomenon individual diversity XOR of being by no means accidental is not by no means inoculated and is caused by analysis; 1, matched group does not have this now; 2, repeatedly repeat, although be minority; 3, document is pointed out, inoculation EAC suspension is 10
6/ ml, success rate 100%; 4, this reverses phenomenon can give counterevidence (promptly do not have the ascites growth and continue just to grow ascites afterwards more than 20 days, life cycle is more than 35 days).Cancer occur to reverse be current dream hide in the hope of thing.
The 8 batches of experiments have 6 batches of laboratory observation life cycles, are wherein arranged all more than 20 days 5 batches of life cycles, and what have reaches average 29 days, surpasses 11-17 days of document record, and a collection of matched group that is lower than is only arranged.
Tested in the 12nd day for the 8th batch and put to death EAC growth curve, ascites volume synchronously; cancerous cell concentration, thymus, spleen weight and blank group all have significant difference (P＜0.05 or P＜0.01); show that GBS truly has remarkable antitumaous effect, the host immune internal organs are had protection and facilitation.Other has 2 about 0.2～0.4ml of mouse ascites amount, microscopy cancerous cell concentration 15～17/mm
3, this is to explain preferably to reversing phenomenon, show medication after the cancerous cell number subtract until disappearance gradually.In table 1 body GBS to the antitumor action group number of animals basis body weight dosage+life cycle course of treatment of mice Ehrlich ascites cell (day) reverse totally ascites
(only) (X+SD) (my god) (only) amount (ml)
(g) 720 730 X+SD (X+SD) GBS, 8 28.25 ± 2.12 0.2ml/ only * 12 2/8 0/8 15.25 ± 3.536 0/8 9.929 ± 2.231NS, 8 29 ± 3.21 0.2ml/ only * 12 0/8 0/8 12.375 ± 1.419 0/8 9.614 ± 3.801 notes: the 4th day, the 6th day GBS and NS relatively in P＜0.05 table 2 body GBS to the antitumor action group number of animals basis body weight dosage of the mouse Ehrlich ascites cell+life cycle course for the treatment of (day) reverse adds up ascites volume
(only) (X+SD) (my god) (only) amount (ml)
(g) 720 730 X+SD, (X+SD) GBS I 10 23.1 ± 3.213 0.2ml/ only * 18 7,/10 1,/10 20 ± 6.733 0,/10 2.98 ± 2.469GBSII, 10 22.05 ± 2.29 0.2ml/ only * 18 9,/10 3,/10 29 ± 11.711 2,/10 3.825 ± 3.569NS, 10 22.75 ± 0.974 0.2ml/ only * 18 8,/10 3,/10 25.8 ± 9.418 0,/10 8.75 ± 5.367 annotates: GBSI compared P＜0.05 with NS in the 6th day
The 14th day GBSI, II and NS relatively in P＜0.05 table 3 body GBS to the anti-swollen effect group number of animals basis body weight dosage+life cycle course of treatment of mice Ehrlich ascytes cell (day) reverse
(g) 720 730 X+SDGBS, 10 33.65 ± 4.565 0.2ml/ only * 8 1,/10 0,/10 15 ± 3.974 0/NSNS, 10 29.95 ± 5.139 0.2ml/ only * 8 4,/10 1,/10 27 ± 4.244 0/10 annotate: because basic body weight exists difference, compare the 6th, 8 day GBS by increasing body weight and compare with NS
In P＜0.05 table 4 body GBS to the antitumor action group number of animals basis body weight dosage+life cycle course of treatment of mice Ehrlich ascites cell (day) reverse totally ascites
(only) (X ± SD) (my god) (only) amount (ml)
(g) 720 730 X+SD (X+SD) GBS, 10 16.8 ± 1.229 0.2ml/ only * 14 5,/10 3,/10 27 ± 5.418 1,/10 8.49 ± 7.87IL-II 10 18.1 ± 1.578,0.5 ten thousand/only * 14 2,/10 1,/10 17 ± 4.268 0,/10 11.92 ± 9.772NS, 10 18.1 ± 2.058 0.2ml/ only * 14 2,/10 1,/10 20 ± 2.264 0,/10 14.35 ± 6.788 notes: the 9th day GBS and the relatively more equal P of IL-II, NS＜0.05
The 13rd day GBS and IL-II, NS relatively all in P＜0.05 table 5 body GBS to the antitumor action group number of animals basis body weight dosage+life cycle course of treatment of mice Ehrlich ascites cell (day) reverse
(only) (X ± SD) (my god) (only)
720 730GBS, 10 15.7 ± 1.033 0.2ml/ only * 10 5,/10 2/10 1/10IL-II 10 16.4 ± 0.568 0.5 ten thousand/only * 10 2,/10 1/10 0/10NBS, 10 16.5 ± 1.130 0.2ml/ only * 10 1,/10 0,/10 0/10
Annotate: the 6th day GBS, IL-II and S relatively in P＜0.05 table 6 body GBS to the antitumor action group number of animals basis body weight dosage+life cycle course of treatment of mice Ehrlich ascites cell (day) reverse adds up ascites volume
(only) (X+SD) (my god) (only) amount (ml)
(g) 720 730 X+SD (X+SD) GBS, 8 22.063 ± 2.352 0.2ml/ only * 18 3/8 1/8 21 ± 6.94 0/8 9.625 ± 6.121IL-II 8 22.188 ± 1.624 0.5 ten thousand/only * 18 1/8 0/8 20 ± 5.36 0/8 17 ± 7.186
Annotate: the 14th day GBS and IL-II relatively in P＜0.05 table 7 body GBS to the basic body weight dosage of the antitumor action group number of animals of the mice Ehrlich ascites cell+life cycle course of treatment (my god) reverse
(only) (g) (my god) (only)
720 730 X ± SDGBS 4 20.25 ± 1.535 0.4ml/ * 19 3/4 1/4 23 ± 5.354 0/4Lentanin, 4 23 ± 3.559 0.002mg/ only * 19 2/4 0/4 18 ± 3.559 0/4
Annotate: compare GBS and Lentanind the 8th day comparison P＜the 0.05th, 12 day by the body weight that is increased
Relatively GBS is heavy to antitumor action group number of animals basis body weight dosage+heavy liver of the heavy spleen of the ascites volume cancerous cell breast spleen course of treatment of mice Ehrlich ascites cell in P＜0.01 table 8 body
(only) (g) (my god) (ml) (10
7/ ml) (mg) (mg) (g) GBS 6 18.357 ± 0.3ml/ only * 11 0.642 ± 97.667 ± 51.367 ± 213.483 ± 1.367 ±
2.304 0.549 85.645 26.147 118.397 0.398Cohtrol 6 17.714 ± blank 9.35 ± 410.53 ± 18.517 ± 59.78 ± 1.15 ±
2.079 annotate 2.519 214.017 6.966 16.65 0.138T values, 8.019 3.322 2.968 3.149 1.262P＜0.01＜0.01＜0.02＜0.02＜0.05: 2 groups of Mus number averages are 7 and found that when putting to death in the 12nd day each group all has a body weight to remain on 15g, stays
Observe and reverse, Coutrol organizes that in death in 14 days, dissect ascites 2ml, and GBS organizes that appearance
Reverse.GBS and Contol be at the 7th day, relatively cut apart P＜0.05, P＜0.01 in 11 days
Claims (9)
1, anticancer goose blood preparation is characterized in that comprising with Sanguis Anseris domestica and makes the preparation that the isolating serum of raw material is made, and/or the preparation made of isolating hemocyte.
2, anticancer goose blood preparation according to claim 1 is characterized in that the goose serum preparation is an oral liquid.
3, as anticancer goose blood preparation as described in the claim 2, the volume that it is characterized in that the goose serum oral liquid is formed and is included as:
Goose serum 50～100%
Honey liquor 10～50%
Lac regis apis 2～15%
And satisfying the each component sum is 100%
4,, it is characterized in that the main optimal volume of goose serum oral liquid is formed as anticancer goose blood preparation as described in the claim 3:
Goose serum 65%
Honey liquor 30%
Lac regis apis 5%
5, as anticancer goose blood preparation as described in the claim 1～4, it is characterized in that goose serum wherein is a fresh serum.
6, anticancer goose blood preparation according to claim 1 is characterized in that the weight of the primary raw material of Sanguis Anseris domestica cell preparation consists of:
10～20 parts of 20～35 portions of Rhizoma Dioscoreaes of Sanguis Anseris domestica cell xeraphium
5～15 parts of 10～15 parts of Fructus Aurantiis of the Pseudobulbus Bletillae (Rhizoma Bletillae)
10～20 parts of 10～20 parts of Rhizoma Corydalis of Rhizoma Curcumae
7, as anticancer goose blood preparation as described in the claim 6, it is characterized in that the optimum weight of primary raw material consists of:
15 parts of 15 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 25 portions of Rhizoma Dioscoreaes of Sanguis Anseris domestica cell xeraphium
10 parts of 10 parts of Rhizoma Corydalis of 10 parts of Rhizoma Curcumae of Fructus Aurantii
8,, it is characterized in that the Sanguis Anseris domestica cell is meant that goose is red, white, platelet cell and solid composition as anticancer goose blood preparation as described in the claim 1,6,7.
9, anticancer goose blood preparation according to claim 1 is characterized in that described preparation is a said dosage form on any materia medica.
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| CN98121673A CN1094052C (en) | 1998-11-23 | 1998-11-23 | Anticancer goose blood preparation |
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|---|---|---|---|
| CN98121673A CN1094052C (en) | 1998-11-23 | 1998-11-23 | Anticancer goose blood preparation |
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| WO2006080019A1 (en) * | 2005-01-31 | 2006-08-03 | Tzuf Globus Ltd. | Bee-food, honey made by bees fed with it, and uses of such honey |
| CN107184772A (en) * | 2017-05-23 | 2017-09-22 | 寿县向天歌白鹅开发有限公司 | A kind of goose blood glue capsule and preparation method thereof |
| CN107348211B (en) * | 2017-06-19 | 2020-11-27 | 黑龙江中医药大学 | Traditional Chinese medicine feed additive for improving quality of goose blood product and application thereof |
| CN107243015A (en) * | 2017-06-22 | 2017-10-13 | 北京中博康医药技术有限公司 | A kind of immunological regulation capsule and preparation method thereof |
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Non-Patent Citations (1)
| Title |
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| 辽宁中医杂志1983,(8) 1983.8.31 陈林才等，中药减少化疗副作用的体会 * |
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Granted publication date: 20021113 |