CN109380729A - A kind of matrimony vine capsule of benefiting qi and nourishing blood and preparation method thereof - Google Patents
A kind of matrimony vine capsule of benefiting qi and nourishing blood and preparation method thereof Download PDFInfo
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- CN109380729A CN109380729A CN201811518269.3A CN201811518269A CN109380729A CN 109380729 A CN109380729 A CN 109380729A CN 201811518269 A CN201811518269 A CN 201811518269A CN 109380729 A CN109380729 A CN 109380729A
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- nourishing
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- fructus lycii
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- 239000002775 capsule Substances 0.000 title claims abstract description 91
- 239000008280 blood Substances 0.000 title claims abstract description 73
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- 235000015459 Lycium barbarum Nutrition 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title claims abstract description 42
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- 239000000203 mixture Substances 0.000 claims abstract description 62
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 56
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 56
- 239000000661 sodium alginate Substances 0.000 claims abstract description 56
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- 239000009636 Huang Qi Substances 0.000 claims abstract description 18
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- 239000011159 matrix material Substances 0.000 claims abstract description 16
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 11
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- 239000007864 aqueous solution Substances 0.000 claims description 14
- 235000013399 edible fruits Nutrition 0.000 claims description 14
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- 241001061264 Astragalus Species 0.000 claims description 7
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- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
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- A61K36/481—Astragalus (milkvetch)
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- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K9/4816—Wall or shell material
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The present invention relates to matrimony vine capsules of a kind of benefiting qi and nourishing blood and preparation method thereof, the matrimony vine capsule of benefiting qi and nourishing blood of the invention, including capsule shells and capsule base, capsule base includes the chitosan for coating the sodium alginate micro ball of qi-tonifying blood-nourishing composition and being coated on outside the sodium alginate micro ball；Qi-tonifying blood-nourishing composition includes fructus lycii fine powder, panaxan, giant salamander oil, Radix Astragali extractum, jujube and lecithin.The preparation method comprises the following steps: first obtaining the sodium alginate micro ball of cladding qi-tonifying blood-nourishing composition；Chitosan is added to the water and is stirred evenly, it is spare to be configured to gel dispersion liquid；It will be sprayed at the microsphere surface of cladding qi-tonifying blood-nourishing composition after the atomization of chitosan gel rubber dispersion liquid, obtains the matrimony vine capsule matrix of benefiting qi and nourishing blood.Matrimony vine capsule of the invention is in addition to containing plurality of active ingredients, and rationally, product is full of nutrition for component proportion, good in taste, has effects that benefiting qi and nourishing blood, antitoxic heart-soothing and sedative.
Description
Technical field
The invention belongs to health product technology fields, are related to a kind of matrimony vine capsule and preparation method thereof of benefiting qi and nourishing blood.
Background technique
Chinese medicine has saying for " blood being the material foundation of QI, qi being the governor of blood ".Commander and promotion of the blood without gas, can not just reach body needs
The place wanted；Based on gas is without blood, gas has reformed into the pathogenic fire in body.The deficiency of vital energy, people will fatigue and weak, shortness of breath lazyness speech,
Loss of appetite is had a dizzy spell, pale complexion；The deficiency of blood, people will palpitations and insomnias, body syntexis, dry skin, sallow complexion.
The women that many is liked to be beautiful often complains that pachylosis, relaxation aging, and long spot, hair loss, they have sighed against mirror
Later, money a large amount of is just fed into beauty parlor, what is as a result brought is only of short duration beauty, does not cross a week, skin
Skin is shown what one really is again.In fact, these symptoms are all caused by qi and blood is unbalance.
Chinese medicine thinks: kidney is congenital body, Shen controls bone, raw marrow, store essential substances.Human five internal organs' six internal organs are both needed to the nourishing of kidney essense.From
From the perspective of Chinese medicine, once there is deficiency of vital energy and blood, kidney deficiency in people, will lead to the reduction of human body allomeric function and occur a series of
Inferior health syndrome.Therefore, in addition to daily life and work it should be noted that appropriate level of work and rest utilizes actively except participation physical training
Some health care products are improved according to the physical condition of itself, and to immunity of organisms is improved, quality of making the life better improves work energy
Power and working efficiency, anti-aging have a very important role.
Summary of the invention
It is an object of the invention to provide a kind of matrimony vine capsules of benefiting qi and nourishing blood.Matrimony vine capsule of the invention is in addition to containing there are many have
Ingredient is imitated, rationally, product is full of nutrition for component proportion, and it is good in taste, have effects that benefiting qi and nourishing blood, antitoxic heart-soothing and sedative.And this hair
Although containing traditional Chinese medicine ingredients in bright, Chinese medicine taste can be effectively covered, it is good in taste.
To solve the above problems, the present invention adopts the following technical scheme:
A kind of matrimony vine capsule of benefiting qi and nourishing blood, including capsule shells and capsule base, the capsule base include cladding benefiting qi and nourishing blood
The sodium alginate micro ball of composition and the chitosan being coated on outside the sodium alginate micro ball；The qi-tonifying blood-nourishing composition packet
Include 40-60 parts of fructus lycii fine powder, 10-20 parts of panaxan, 3-5 parts of giant salamander oil, 20-30 parts of Radix Astragali extractum, jujube fine powder 10-25
Part and lecithin 10-15 parts.Capsule shells of the invention select conventional capsule shell commonly used in the prior art.
As the further improvement of above-described embodiment, the fructus lycii fine powder is Ningxia lycium ruthenicum fine powder.
As the further improvement of above-described embodiment, the qi-tonifying blood-nourishing composition includes 30-50 parts of fructus lycii fine powder, ginseng
15-20 parts of polysaccharide, 8-10 parts of giant salamander oil, 20-30 parts of Radix Astragali extractum, 20-25 parts of jujube fine powder and 10-15 parts of lecithin.Its
In, giant salamander oil is directly bought from existing.
As the further improvement of above-described embodiment, the molecular weight of the chitosan is 5-10 ten thousand.
The present invention also provides a kind of preparation methods of the matrimony vine capsule of benefiting qi and nourishing blood, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 4wt%, in proportion by qi-tonifying blood-nourishing composition
It is added in sodium alginate aqueous solution, stirring is uniformly mixed it, then turns sodium alginate-qi-tonifying blood-nourishing composition mixed liquor
Entering into constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 8%, stirring solidification 15-20 minutes,
Filtering, is placed in 25-35 DEG C of vacuum drying, obtains the sodium alginate micro ball of cladding qi-tonifying blood-nourishing composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) sodium alginate micro ball of step (1) cladding qi-tonifying blood-nourishing composition is added in fluidized bed spray granulation machine, adjusts stream
Change gas velocity is 2.5m/s, fluidized-bed layer temperature is 55 DEG C, atomization air pressure 0.3MPa, by the chitosan gel rubber of step (2)
The microsphere surface that cladding qi-tonifying blood-nourishing composition is uniformly sprayed at after dispersion liquid atomization obtains after fluidized drying is handled 25-35 minutes
To the matrimony vine capsule matrix (forming graininess matrimony vine capsule matrix) of benefiting qi and nourishing blood, the matrimony vine capsule matrix of benefiting qi and nourishing blood is added
The matrimony vine capsule of benefiting qi and nourishing blood is made in capsule shells.
As the further improvement of above-described embodiment, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is cut
Fructus lycii pulp is obtained to 2~3mm powder；B enzymatic hydrolysis: in the fructus lycii pulp obtained by step a, according to the quality of fructus lycii pulp and hydrolase
Than hydrolase is added for 100: 0.2~8, enzyme digestion reaction is carried out under constant temperature stirring condition, the time is 40-90 minutes, obtains fructus lycii
Digest pulp；The hydrolase is cellulase or the complex enzyme being made of pectase and cellulase；C freeze-drying: it will walk
It is to obtain fructus lycii dry crushing within 5% that fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by rapid b, which is freeze-dried under vacuum conditions to water content,
End；D is pulverized: the Chinese wolfberry fruit dry powder after step c freeze-drying process is pulverized the particle diameter to 90% less than 6
μm, obtain fructus lycii fine powder.
As the further improvement of above-described embodiment, the preparation method of the jujube fine powder is identical as fructus lycii fine powder.
As the further improvement of above-described embodiment, the preparation method of the Radix Astragali extractum is that ethyl alcohol is added in Milkvetch Root
In, it impregnates, decocts, be concentrated to get medicinal extract, it is dry.
As the further improvement of above-described embodiment, the time of the immersion is 0.5h~2h；The temperature of the decoction
Degree is 80 DEG C~100 DEG C；The relative density of the medicinal extract is 1.1~1.4 at 60 DEG C.
Beneficial effect
The matrimony vine capsule of benefiting qi and nourishing blood of the invention uses sodium alginate as shell, is tentatively wrapped to qi-tonifying blood-nourishing composition
It covers, utilizes aldehyde groups later, crosslink and react with chitosan, introduced on sodium alginate cladding qi-tonifying blood-nourishing composition surface
Temperature sensitive polymer is realized and is coated to the double-layer sustained release of qi-tonifying blood-nourishing composition, is reached sustained release and is protected qi-tonifying blood-nourishing composition
Effect reduces nutrition loss and waste.
The matrimony vine capsule of benefiting qi and nourishing blood of the invention has good antibacterial activity using chitosan shell, anti-being added without
The pollution of matrimony vine capsule is avoided in the case where the additives such as rotten agent.
The matrimony vine capsule of benefiting qi and nourishing blood of the invention coats qi-tonifying blood-nourishing composition, benefiting qi and nourishing blood using sodium alginate first
Contain traditional Chinese medicine ingredients in composition, Chinese medicine taste will affect mouthfeel, can be with by the double shielding of sodium alginate and chitosan
Improve matrimony vine capsule takes mouthfeel
In matrimony vine capsule of the invention, lecithin is a kind of natural antidote, can decompose intracorporal toxin, blood red by increasing
Element, giant salamander can with clever intelligence development, anti-aging, improve hematopoiesis and immune function, to preventing diseases of cardiovascular and cerebrovascular systems, pernicious poor
Blood and malignant tumour have good effect, Radix Astragali: Buqi Yangxue, Gu table arrest sweating；Ginseng: blood-enrich, skin maintenance and cosmetic benefits；Fructus lycii:
It is nourishing liver and kidney, benefiting shrewd head；Jujube: tonifying middle-Jiao and Qi, nourishing blood and tranquilization.Product of the present invention is full of nutrition, good in taste, has tonifying Qi
The effect of blood-nourishing, antitoxic heart-soothing and sedative.
Specific embodiment
The invention will be further elucidated with reference to specific embodiments.It should be understood that these embodiments are merely to illustrate this hair
It is bright rather than limit the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, art technology
Personnel can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Fixed range.
Embodiment 1
A kind of matrimony vine capsule of benefiting qi and nourishing blood, including capsule shells and capsule base, capsule base include cladding benefiting qi and nourishing blood combination
The sodium alginate micro ball of object and the chitosan being coated on outside sodium alginate micro ball；Qi-tonifying blood-nourishing composition includes fructus lycii fine powder 40
Part, 10 parts of panaxan, 3 parts of giant salamander oil, 30 parts of Radix Astragali extractum, 15 parts of jujube and 15 parts of lecithin.Wherein, fructus lycii fine powder is peaceful
Summer lycium ruthenicum fine powder, the molecular weight of chitosan are 100,000, giant salamander oil the preparation method comprises the following steps: the giant salamander of fresh slaughter, takes tail portion rouge
Fat tissue 1kg, is cut into small pieces, and sets in stainless steel jacketed pan, is passed through heat steam, 100 DEG C is heated about 2 hours, obtained oil
Liquid is filtered, removes slag, is centrifuged, and takes supernatant oil liquid, obtains pure giant salamander oil.
The preparation method of the matrimony vine capsule of above-mentioned benefiting qi and nourishing blood, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 4wt%, in proportion by qi-tonifying blood-nourishing composition
It is added in sodium alginate aqueous solution, stirring is uniformly mixed it, then turns sodium alginate-qi-tonifying blood-nourishing composition mixed liquor
Enter into constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 8%, stirring solidification 15 minutes, mistake
Filter, is placed in 35 DEG C of vacuum drying, obtains the sodium alginate micro ball of cladding qi-tonifying blood-nourishing composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) sodium alginate micro ball of step (1) cladding qi-tonifying blood-nourishing composition is added in fluidized bed spray granulation machine, adjusts stream
Change gas velocity is 2.5m/s, fluidized-bed layer temperature is 55 DEG C, atomization air pressure 0.3MPa, by the chitosan gel rubber of step (2)
The microsphere surface that cladding qi-tonifying blood-nourishing composition is uniformly sprayed at after dispersion liquid atomization obtains after fluidized drying is handled 25 minutes
The fructus lycii that benefiting qi and nourishing blood is made is added in capsule shells in the matrimony vine capsule matrix of benefiting qi and nourishing blood by the matrimony vine capsule matrix of benefiting qi and nourishing blood
Capsule.
Wherein, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 3mm powder and obtains fructus lycii pulp；B enzyme
Solution: being 100: 0.2 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase, in perseverance in the fructus lycii pulp obtained by step a
Enzyme digestion reaction is carried out under warm stirring condition, the time is 40 minutes, obtains fructus lycii enzymatic hydrolysis pulp；Hydrolase is for cellulase or by pectin
The complex enzyme of enzyme and cellulase composition；C freeze-drying: by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b in vacuum condition
Lower freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5%；D is pulverized: will be after step c freeze-drying process
Chinese wolfberry fruit dry powder is pulverized to 90% particle diameter less than 6 μm, obtains fructus lycii fine powder.
The preparation method of jujube fine powder is identical as fructus lycii fine powder.
The preparation method of Radix Astragali extractum is that Milkvetch Root is added in ethyl alcohol, impregnates, decocts, be concentrated to get medicinal extract, drying is
It can；The time wherein impregnated is 2h；Decoction temperature be 80 DEG C；The relative density of medicinal extract at 60 DEG C is 1.1.
Embodiment 2
A kind of matrimony vine capsule of benefiting qi and nourishing blood, including capsule shells and capsule base, capsule base include cladding benefiting qi and nourishing blood combination
The sodium alginate micro ball of object and the chitosan being coated on outside sodium alginate micro ball；Qi-tonifying blood-nourishing composition includes fructus lycii fine powder 60
Part, 20 parts of panaxan, 5 parts of giant salamander oil, 20 parts of Radix Astragali extractum, 25 parts of jujube and 10 parts of lecithin.
Wherein, fructus lycii fine powder is Ningxia lycium ruthenicum fine powder, and the molecular weight of chitosan is 50,000, and the preparation method of giant salamander oil is same
Embodiment 1.
The preparation method of the matrimony vine capsule of above-mentioned benefiting qi and nourishing blood, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 4wt%, in proportion by qi-tonifying blood-nourishing composition
It is added in sodium alginate aqueous solution, stirring is uniformly mixed it, then turns sodium alginate-qi-tonifying blood-nourishing composition mixed liquor
Enter into constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 8%, stirring solidification 20 minutes, mistake
Filter, is placed in 25 DEG C of vacuum drying, obtains the sodium alginate micro ball of cladding qi-tonifying blood-nourishing composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) sodium alginate micro ball of step (1) cladding qi-tonifying blood-nourishing composition is added in fluidized bed spray granulation machine, adjusts stream
Change gas velocity is 2.5m/s, fluidized-bed layer temperature is 55 DEG C, atomization air pressure 0.3MPa, by the chitosan gel rubber of step (2)
The microsphere surface that cladding qi-tonifying blood-nourishing composition is uniformly sprayed at after dispersion liquid atomization obtains after fluidized drying is handled 35 minutes
The fructus lycii that benefiting qi and nourishing blood is made is added in capsule shells in the matrimony vine capsule matrix of benefiting qi and nourishing blood by the matrimony vine capsule matrix of benefiting qi and nourishing blood
Capsule.
Wherein, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 2mm powder and obtains fructus lycii pulp；B enzyme
Solution: being 100: 8 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase, in constant temperature in the fructus lycii pulp obtained by step a
Enzyme digestion reaction is carried out under stirring condition, the time is 90 minutes, obtains fructus lycii enzymatic hydrolysis pulp；Hydrolase is for cellulase or by pectase
With the complex enzyme of cellulase composition；C freeze-drying: under vacuum conditions by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b
Freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5%；D is pulverized: by the Chinese holly after step c freeze-drying process
Qi dry crushing end is pulverized to 90% particle diameter less than 6 μm, obtains fructus lycii fine powder.
The preparation method of jujube fine powder is identical as fructus lycii fine powder.
The preparation method of Radix Astragali extractum is that Milkvetch Root is added in ethyl alcohol, impregnates, decocts, be concentrated to get medicinal extract, drying is
It can；The time of immersion is 0.5h；100 DEG C of temperature of decoction；The relative density of medicinal extract at 60 DEG C is 1.4.
Embodiment 3
A kind of matrimony vine capsule of benefiting qi and nourishing blood, including capsule shells and capsule base, capsule base include cladding benefiting qi and nourishing blood combination
The sodium alginate micro ball of object and the chitosan being coated on outside sodium alginate micro ball；Qi-tonifying blood-nourishing composition includes fructus lycii fine powder 30
Part, 20 parts of panaxan, 4 parts of giant salamander oil, 30 parts of Radix Astragali extractum, 10 parts of jujube fine powder and 12 parts of lecithin.
Wherein, fructus lycii fine powder is Ningxia lycium ruthenicum fine powder, and the molecular weight of chitosan is 70,000, and the preparation method of giant salamander oil is same
Embodiment 1.
The preparation method of the matrimony vine capsule of above-mentioned benefiting qi and nourishing blood, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 4wt%, in proportion by qi-tonifying blood-nourishing composition
It is added in sodium alginate aqueous solution, stirring is uniformly mixed it, then turns sodium alginate-qi-tonifying blood-nourishing composition mixed liquor
Enter into constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 8%, stirring solidification 18 minutes, mistake
Filter, is placed in 30 DEG C of vacuum drying, obtains the sodium alginate micro ball of cladding qi-tonifying blood-nourishing composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) sodium alginate micro ball of step (1) cladding qi-tonifying blood-nourishing composition is added in fluidized bed spray granulation machine, adjusts stream
Change gas velocity is 2.5m/s, fluidized-bed layer temperature is 55 DEG C, atomization air pressure 0.3MPa, by the chitosan gel rubber of step (2)
The microsphere surface that cladding qi-tonifying blood-nourishing composition is uniformly sprayed at after dispersion liquid atomization obtains after fluidized drying is handled 30 minutes
The fructus lycii that benefiting qi and nourishing blood is made is added in capsule shells in the matrimony vine capsule matrix of benefiting qi and nourishing blood by the matrimony vine capsule matrix of benefiting qi and nourishing blood
Capsule.
Wherein, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 2.3mm powder and obtains fructus lycii pulp；b
Enzymatic hydrolysis: being 100: 6 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase, in perseverance in the fructus lycii pulp obtained by step a
Enzyme digestion reaction is carried out under warm stirring condition, the time is 70 minutes, obtains fructus lycii enzymatic hydrolysis pulp；Hydrolase is for cellulase or by pectin
The complex enzyme of enzyme and cellulase composition；C freeze-drying: by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b in vacuum condition
Lower freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5%；D is pulverized: will be after step c freeze-drying process
Chinese wolfberry fruit dry powder is pulverized to 90% particle diameter less than 6 μm, obtains fructus lycii fine powder.
The preparation method of jujube fine powder is identical as fructus lycii fine powder.
The preparation method of Radix Astragali extractum is that Milkvetch Root is added in ethyl alcohol, impregnates, decocts, be concentrated to get medicinal extract, drying is
It can；The time of immersion is 1h；Decoction temperature be 90 DEG C；The relative density of medicinal extract at 60 DEG C is 1.3.
Embodiment 4
A kind of matrimony vine capsule of benefiting qi and nourishing blood, including capsule shells and capsule base, capsule base include cladding benefiting qi and nourishing blood combination
The sodium alginate micro ball of object and the chitosan being coated on outside sodium alginate micro ball；Qi-tonifying blood-nourishing composition includes fructus lycii fine powder 50
Part, 15 parts of panaxan, 5 parts of giant salamander oil, 20 parts of Radix Astragali extractum, 20 parts of jujube fine powder and 10 parts of lecithin.Wherein, fructus lycii fine powder
For Ningxia lycium ruthenicum fine powder, the molecular weight of chitosan is 80,000, and the preparation method is the same as that of Example 1 for giant salamander oil.
The preparation method of the matrimony vine capsule of above-mentioned benefiting qi and nourishing blood, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 4wt%, in proportion by qi-tonifying blood-nourishing composition
It is added in sodium alginate aqueous solution, stirring is uniformly mixed it, then turns sodium alginate-qi-tonifying blood-nourishing composition mixed liquor
Enter into constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 8%, stirring solidification 16 minutes, mistake
Filter, is placed in 28 DEG C of vacuum drying, obtains the sodium alginate micro ball of cladding qi-tonifying blood-nourishing composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) sodium alginate micro ball of step (1) cladding qi-tonifying blood-nourishing composition is added in fluidized bed spray granulation machine, adjusts stream
Change gas velocity is 2.5m/s, fluidized-bed layer temperature is 55 DEG C, atomization air pressure 0.3MPa, by the chitosan gel rubber of step (2)
The microsphere surface that cladding qi-tonifying blood-nourishing composition is uniformly sprayed at after dispersion liquid atomization obtains after fluidized drying is handled 26 minutes
The fructus lycii that benefiting qi and nourishing blood is made is added in capsule shells in the matrimony vine capsule matrix of benefiting qi and nourishing blood by the matrimony vine capsule matrix of benefiting qi and nourishing blood
Capsule.
Wherein, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 2.53mm powder and obtains fructus lycii pulp；
B enzymatic hydrolysis: being 100: 5 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase in the fructus lycii pulp obtained by step a,
Enzyme digestion reaction is carried out under constant temperature stirring condition, the time is 60 minutes, obtains fructus lycii enzymatic hydrolysis pulp；Hydrolase is for cellulase or by fruit
The complex enzyme of glue enzyme and cellulase composition；C freeze-drying: by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b in vacuum item
Freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5% under part；D is pulverized: will be after step c freeze-drying process
Chinese wolfberry fruit dry powder pulverize to 90% particle diameter less than 6 μm, obtain fructus lycii fine powder.
The preparation method of jujube fine powder is identical as fructus lycii fine powder.
The preparation method of Radix Astragali extractum is that Milkvetch Root is added in ethyl alcohol, impregnates, decocts, be concentrated to get medicinal extract, drying is
It can；The time of immersion is 1.5h；Decoction temperature be 85 DEG C；The relative density of medicinal extract at 60 DEG C is 1.3.
Embodiment 5
A kind of matrimony vine capsule of benefiting qi and nourishing blood, including capsule shells and capsule base, capsule base include cladding benefiting qi and nourishing blood combination
The sodium alginate micro ball of object and the chitosan being coated on outside sodium alginate micro ball；3. qi-tonifying blood-nourishing composition includes fructus lycii fine powder
50 parts, 20 parts of panaxan, 4 parts of giant salamander oil, 25 parts of Radix Astragali extractum, 10 parts of jujube fine powder and 14 parts of lecithin.Wherein, fructus lycii is thin
Powder is Ningxia lycium ruthenicum fine powder, and the molecular weight of chitosan is 80,000, and the preparation method is the same as that of Example 1 for giant salamander oil.
The preparation method of the matrimony vine capsule of above-mentioned benefiting qi and nourishing blood, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 4wt%, in proportion by qi-tonifying blood-nourishing composition
It is added in sodium alginate aqueous solution, stirring is uniformly mixed it, then turns sodium alginate-qi-tonifying blood-nourishing composition mixed liquor
Enter into constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 8%, stirring solidification 16 minutes, mistake
Filter, is placed in 28 DEG C of vacuum drying, obtains the sodium alginate micro ball of cladding qi-tonifying blood-nourishing composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) sodium alginate micro ball of step (1) cladding qi-tonifying blood-nourishing composition is added in fluidized bed spray granulation machine, adjusts stream
Change gas velocity is 2.5m/s, fluidized-bed layer temperature is 55 DEG C, atomization air pressure 0.3MPa, by the chitosan gel rubber of step (2)
The microsphere surface that cladding qi-tonifying blood-nourishing composition is uniformly sprayed at after dispersion liquid atomization obtains after fluidized drying is handled 26 minutes
The fructus lycii that benefiting qi and nourishing blood is made is added in capsule shells in the matrimony vine capsule matrix of benefiting qi and nourishing blood by the matrimony vine capsule matrix of benefiting qi and nourishing blood
Capsule.
Wherein, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 2.53mm powder and obtains fructus lycii pulp；
B enzymatic hydrolysis: being 100: 5 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase in the fructus lycii pulp obtained by step a,
Enzyme digestion reaction is carried out under constant temperature stirring condition, the time is 60 minutes, obtains fructus lycii enzymatic hydrolysis pulp；Hydrolase is for cellulase or by fruit
The complex enzyme of glue enzyme and cellulase composition；C freeze-drying: by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b in vacuum item
Freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5% under part；D is pulverized: will be after step c freeze-drying process
Chinese wolfberry fruit dry powder pulverize to 90% particle diameter less than 6 μm, obtain fructus lycii fine powder.
The preparation method of jujube fine powder is identical as fructus lycii fine powder.
The preparation method of Radix Astragali extractum is that Milkvetch Root is added in ethyl alcohol, impregnates, decocts, be concentrated to get medicinal extract, drying is
It can；The time of immersion is 1.5h；Decoction temperature be 85 DEG C；The relative density of medicinal extract at 60 DEG C is 1.3.
Two, performance detection
Clinical application cases:
Case 1: Mr. Li, female, 40 years old.
It has a delicate constitution, complexion is dim, has anemia symptom, takes 2 product of the embodiment of the present invention, after a week, complexion has
Improved, using after three weeks, full of physical strength, Anemia disappears；
Case 2: the Qin, female, 55 years old.
In poor health due to working hard for a long time, insufficiency of vital energy and blood, blood pressure is relatively low, it sometimes appear that the symptom of dizziness or shock.Clothes
After 4 product of the present embodiment, physical condition improves, and energetic, blood pressure is normal.
Claims (9)
1. a kind of matrimony vine capsule of benefiting qi and nourishing blood, characterized in that including capsule shells and capsule base, the capsule base includes packet
Cover the sodium alginate micro ball of qi-tonifying blood-nourishing composition and the chitosan being coated on outside the sodium alginate micro ball；The tonifying Qi is supported
Blood composition includes 40-60 parts of fructus lycii fine powder, 10-20 parts of panaxan, 3-5 parts of giant salamander oil, 20-30 parts of Radix Astragali extractum, jujube
10-25 parts and lecithin 10-15 parts of fine powder.
2. a kind of matrimony vine capsule of benefiting qi and nourishing blood according to claim 1, which is characterized in that the fructus lycii fine powder is Ningxia
Lycium ruthenicum fine powder.
3. a kind of matrimony vine capsule of benefiting qi and nourishing blood according to claim 1, which is characterized in that the qi-tonifying blood-nourishing composition
Including 50 parts of fructus lycii fine powder, 20 parts of panaxan, 4 parts of giant salamander oil, 25 parts of Radix Astragali extractum, 10 parts of jujube fine powder and lecithin 12
Part.
4. a kind of matrimony vine capsule of benefiting qi and nourishing blood according to claim 1, which is characterized in that the molecular weight of the chitosan
For 5-10 ten thousand.
5. a kind of preparation method of the matrimony vine capsule of benefiting qi and nourishing blood according to claim 1 to 4, which is characterized in that packet
Include following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 4wt%, in proportion by qi-tonifying blood-nourishing composition
It is added in sodium alginate aqueous solution, stirring is uniformly mixed it, then turns sodium alginate-qi-tonifying blood-nourishing composition mixed liquor
Entering into constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 8%, stirring solidification 15-20 minutes,
Filtering, is placed in 25-35 DEG C of vacuum drying, obtains the sodium alginate micro ball of cladding qi-tonifying blood-nourishing composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) sodium alginate micro ball of step (1) cladding qi-tonifying blood-nourishing composition is added in fluidized bed spray granulation machine, adjusts stream
Change gas velocity is 2.5m/s, fluidized-bed layer temperature is 55 DEG C, atomization air pressure 0.3MPa, by the chitosan gel rubber of step (2)
The microsphere surface that cladding qi-tonifying blood-nourishing composition is uniformly sprayed at after dispersion liquid atomization obtains after fluidized drying is handled 25-35 minutes
To the matrimony vine capsule matrix of benefiting qi and nourishing blood, the matrimony vine capsule matrix of benefiting qi and nourishing blood is added in capsule shells to the Chinese holly that benefiting qi and nourishing blood is made
Qi capsule.
6. a kind of preparation method of the matrimony vine capsule of benefiting qi and nourishing blood according to claim 5, which is characterized in that fructus lycii fine powder
The preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 2~3mm powder and obtains fructus lycii pulp；B enzymatic hydrolysis: the fructus lycii obtained by step a
In pulp, according to the mass ratio of fructus lycii pulp and hydrolase be 100: 0.2~8 be added hydrolases, under constant temperature stirring condition into
Row enzyme digestion reaction, time are 40-90 minutes, obtain fructus lycii enzymatic hydrolysis pulp；The hydrolase is for cellulase or by pectase and fibre
Tie up the complex enzyme of plain enzyme composition；C freeze-drying: the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b is freezed under vacuum conditions
Drying to water content is to obtain Chinese wolfberry fruit dry powder within 5%；D is pulverized: by the Chinese wolfberry fruit dry after step c freeze-drying process
Powder is pulverized to 90% particle diameter less than 6 μm, obtains fructus lycii fine powder.
7. a kind of preparation method of the matrimony vine capsule of benefiting qi and nourishing blood according to claim 5, which is characterized in that the jujube
The preparation method of fine powder is identical as fructus lycii fine powder.
8. a kind of preparation method of the matrimony vine capsule of benefiting qi and nourishing blood according to claim 5, which is characterized in that the Radix Astragali
The preparation method of medicinal extract is that Milkvetch Root is added in ethyl alcohol, impregnates, decocts, be concentrated to get medicinal extract, dry.
9. a kind of preparation method of the matrimony vine capsule of benefiting qi and nourishing blood according to claim 7, which is characterized in that the leaching
The time of bubble is 0.5h~2h；The temperature of the decoction is 80 DEG C~100 DEG C；The relative density of the medicinal extract is at 60 DEG C
1.1~1.4.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111528472A (en) * | 2020-06-15 | 2020-08-14 | 宁夏新东方技工学校有限公司 | Edible roe-shaped Chinese wolfberry capsule and preparation method thereof |
| CN114568557A (en) * | 2022-02-14 | 2022-06-03 | 武汉市紫物源科技有限责任公司 | Ginseng polysaccharide sweet golden flower black tea and preparation method thereof |
-
2018
- 2018-12-12 CN CN201811518269.3A patent/CN109380729A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111528472A (en) * | 2020-06-15 | 2020-08-14 | 宁夏新东方技工学校有限公司 | Edible roe-shaped Chinese wolfberry capsule and preparation method thereof |
| CN114568557A (en) * | 2022-02-14 | 2022-06-03 | 武汉市紫物源科技有限责任公司 | Ginseng polysaccharide sweet golden flower black tea and preparation method thereof |
| CN114568557B (en) * | 2022-02-14 | 2024-01-26 | 武汉市紫物源科技有限责任公司 | Ginseng polysaccharide sweet golden flower black tea and preparation method thereof |
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Application publication date: 20190226 |
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