CN109380226A - A kind of preparation method of colloidal suspending agent - Google Patents
A kind of preparation method of colloidal suspending agent Download PDFInfo
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- CN109380226A CN109380226A CN201811361681.9A CN201811361681A CN109380226A CN 109380226 A CN109380226 A CN 109380226A CN 201811361681 A CN201811361681 A CN 201811361681A CN 109380226 A CN109380226 A CN 109380226A
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- agent
- methaldehyde
- preparation
- suspending agent
- bayluscid
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to blood fluke epidemic integrated control technique fields, in particular disclose a kind of preparation method of colloidal suspending agent, including using bayluscid and the methaldehyde as active constituent, it is aided with auxiliary material pesticide-acceptable, auxiliary material includes wetting agent 1~5%, dispersing agent 1~20%, antifreezing agent 1~10%, preservative 0.1~1%, pH adjusting agent 0.1~1%, defoaming agent 0.1~1%, thickener 0.1~2%, deionized water complements to 100%, and above-mentioned each component can be prepared by aqueous suspension agent by being ground to 1~10um after mixing；Wherein the mass ratio of bayluscid and the methaldehyde is 1~50: 1~10.Fine size of the present invention, general 2~5um of partial size, suspensibility is high, and drug effect is higher than wettable powder；It can be mixed with water with arbitrary proportion, it is easy to use, there is apparent synthesis and economic benefit.
Description
Technical field
The present invention relates to blood fluke epidemic integrated control technique field more particularly to a kind of preparation sides of colloidal suspending agent
Method.
Background technique
Currently, niclosamidum is main snail killing agent, no special odor is non-stimulated to skin, low to people and animals' toxicity,
Crops are not damaged, application can be directly diluted with water.And the medicine kills that spiral shell effect is big, and holding effect is long.But existing niclosamidum
Various pulvis dissolubility and dispersibility it is undesirable, not only wetting time is long, but also after being diluted with water, the water surface is soon by bright
Yellow becomes rufous.There is flocculation phenomenon in drug particle aggregation simultaneously, not only pollution water surfaces but also effective component cannot be fine
It is evenly dispersed, charge effect causes partial size bigger, cannot play due drug effect, and only small part really reaches target, one
Denier flocculation causes drug effect performance slow and cannot be lasting, and in hard water, this phenomenon is more serious.The spiral shell effect that causes to go out is poor, no
Conducive to the propagation of control schistosomiasis.And small lumpy precipitate easily blocks drug-spraying instrument, causes sprinkling difficult.
The methaldehyde is a kind of white, needle-shaped crystals, has ignition temperature high, flame stabilization is non-volatile, not soluble in water etc.
Feature has the title of solid alcohol, can be used for manufacturing firecrackers, fireworks, colour candle, silver iodide can be replaced to make rain making agent, also
It can be used for killing the oncomelania etc. of the lungs such as snail, slug class software pest and blood sucker parasitism, outstanding advantages are to can inhibit oncomelania
It swashes, it is low to aquatic toxicity.But both there are problems that medication difficulty and drug resistance generate, and both for indissoluble
In the drug of water, wettable powder drug effect is not high, and dosage is big, and dust easily drifts about, and environment easy to pollute is inconvenient to use.
Summary of the invention
The purpose of the present invention is overcoming the drug resistance problems of existing bayluscid, one kind is provided and contains chlorine nitre willow
The colloidal suspending agent of amine ethanolamine salt and the methaldehyde.
To achieve the goals above, present invention employs following technical solutions:
A kind of preparation method of colloidal suspending agent, including using bayluscid and the methaldehyde as active constituent, be aided with
Auxiliary material pesticide-acceptable, auxiliary material include wetting agent 1~5%, dispersing agent 1~20%, antifreezing agent 1~10%, preservative 0.1
~1%, pH adjusting agent 0.1~1%, defoaming agent 0.1~1%, thickener 0.1~2%, deionized water complements to 100%, will be upper
Stating each component can be prepared by aqueous suspension agent by being ground to 1~10um after mixing；Wherein bayluscid and four
The mass ratio of metacetaldehyde is 1~50: 1~10.
Preferably, for the colloidal suspending agent using bayluscid and the methaldehyde as active constituent, being aided on pesticide can
Emulsion, water dispersible granules is made in the auxiliary material of receiving.
Preferably, the content of the bayluscid is 1~50%, and the methaldehyde content is 1~5%.
Preferably, the wetting agent is selected from lauryl sodium sulfate, pull open powder, alkyl phenol polyoxyethylene ether, poly alkyl alcohol
One or more of ethylene oxide ether, aliphatic acid polyethenoxy ether, alkyl glycosides.
Preferably, the dispersing agent is selected from sodium methylene bis-naphthalene sulfonate, lignosulfonates, polycarboxylate sodium, alkyl phenol
One or more of polyoxyethylene ether phosphate, speed pool 270.
Preferably, the antifreezing agent is selected from one or more of ethylene glycol, glycerine, urea, sodium chloride；The anti-corrosion
One or more of sodium benzoate, Kathon CG, formaldehyde are selected in agent；The pH adjusting agent be selected from benzoic acid, glacial acetic acid, citric acid,
One or more of hydrochloric acid；The defoaming agent is selected from one or more of organic silicone, polyethers, butanol；The thickener
Selected from one or more of xanthan gum, gelatin, Arabic gum, bentonite, aluminium-magnesium silicate.
A kind of preparation method of colloidal suspending agent proposed by the present invention, this colloidal suspending agent have obvious synergistic function, and can have
Effect overcomes the drug resistance problems of oncomelania.Bayluscid and the methaldehyde aqueous suspension agent prevention spectrum produced by the present invention into
One step expands, and molluscicidal effect is good, does not use organic solvent, volatility is small, toxicity is low, safe for human and animal and environment；It is nonflammable easy
It is quick-fried, storing safety.Fine size, general 2~5um of partial size, suspensibility is high, and drug effect is higher than wettable powder；It can be with water arbitrarily to compare
Example mixing, it is easy to use, there is apparent synthesis and economic benefit.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.
Embodiment 1:
+ 1% methaldehyde suspending agent of 30% bayluscid by percentage to the quality, bayluscid
30%, the methaldehyde 1%, alkyl phenol polyoxyethylene ether 2%, polycarboxylate sodium 2%, sodium methylene bis-naphthalene sulfonate salt 3%, second two
Alcohol 5%, benzoic acid 1%, organic silicone defoaming agent 0.5%, Kathon CG 0.2%, xanthan gum 0.2% are ground to 2 through multistage sand mill
+ 1% methaldehyde SC of 30% bayluscid is made in~3um.
Embodiment 2:
+ 1% methaldehyde suspending agent of 45% bayluscid by percentage to the quality, bayluscid
45%, the methaldehyde 1%, fatty alcohol polyoxyethylene ether 3%, polycarboxylate sodium 2%, SOPA (speed pool) 2703%, ethylene glycol
5%, benzoic acid 1%, organic silicone defoaming agent 0.5%, Kathon CG 0.2%, xanthan gum 0.1%, it is qualified to grind through multistage sand mill,
+ 1% methaldehyde SC of 45% bayluscid is made.
Embodiment 3:
+ 1% methaldehyde suspending agent of 25% bayluscid by percentage to the quality, bayluscid
25%, the methaldehyde 1%, lauryl sodium sulfate 2%, sodium methylene bis-naphthalene sulfonate salt 5%, calcium lignosulfonate 5%, second two
Alcohol 5%, benzoic acid 0.3%, organic silicone defoaming agent 0.5%, Kathon CG 0.2%, xanthan gum 0.3%, deionized water complements to
100%.Each component is uniformly mixed with this ratio high-shear emulsifying dispersion machine, is ground to 2~3um through multistage sand mill, is made
+ 1% methaldehyde SC of 25% bayluscid.
Embodiment 4:
It spends coefficient together and 100ml medical fluid is poured into beaker and be settled to 200ml respectively, every beaker is put into be followed closely containing 30
3 bags of the spiral shell bag of spiral shell, medical fluid depth are higher by spiral shell 2~3cm of bag, while setting clear water (dechlorination water) control.After spiral shell bag immerses medical fluid
For 24 hours, respectively take out 1 bag after 48h and 72h, after clear water cleans drying, 72h convalescence raise after with hammering method identification Death of Oncomelania Snails
And survival number.It is calculated with Finny (1952) probit analysis and finds out various single doses and the different LD50 values assembled, then basis
Sun method (1960) calculates co-toxicity coefficient (CTC), and the co-toxicity effect of compounding agent, CTC value 80-120 or so are judged with CTC value
For summation action, hence it is evident that be antagonism when less than 80, hence it is evident that be synergistic effect when being greater than 120.
Embodiment 5:
+ 1% methaldehyde suspending agent of 15% bayluscid by percentage to the quality, bayluscid
15%, the methaldehyde 1%, aliphatic acid polyethenoxy ether 2%, sodium methylene bis-naphthalene sulfonate salt 5%, calcium lignosulfonate 5%, second
Glycol 5%, benzoic acid 0.3%, organic silicone defoaming agent 0.5%, Kathon CG 0.2%, xanthan gum 0.3%, deionized water complements to
100%.Each component is uniformly mixed with this ratio high-shear emulsifying dispersion machine, is ground to 2~3um through multistage sand mill, is made
+ 1% methaldehyde SC of 15% bayluscid.
From the data of table 1 can be seen that bayluscid and the methaldehyde compounding after, have more apparent synergy
Effect.
The effect of 1 bayluscid of table-methaldehyde 72h co-toxicity
| Group number | Pesticide species | Virulence regression equation | Co-toxicity coefficient |
| 1 | Bayluscid | Y=7.7977+3.4980X | / |
| 2 | The methaldehyde | Y=5.3103+1.6816X | / |
| 3 | Bayluscid: the methaldehyde (10: 1) | Y=8.8075+4.3354X | 129 |
| 4 | Bayluscid: the methaldehyde (25: 1) | Y=7.9559+2.7934X | 187 |
| 5 | Bayluscid: the methaldehyde (50: 1) | Y=7.8788+3.1312X | 134 |
| 6 | Bayluscid: the methaldehyde (1: 1) | Y=6.2037+1.5598X | 151 |
Embodiment 6:
The bayluscid and four poly- second that use for laboratory embodiment 2 obtains when laboratory leaching kills 25 DEG C of oncomelania effect
The compounding suspending agent of aldehyde is configured to effective component concentration 0.5,0.25,0.125,0.0625 and spiral shell is killed in the immersion of 0.0313 mg/litre
It 24 hours, 48 hours and 72 hours, is carried out with 50% Niclosamide ethanolamine salt wettable powder agent and 1% methaldehyde suspending agent
Comparative test.The bayluscid methaldehyde compound 0.125 mg/litre of suspending agent effective component concentration impregnate oncomelania at
It was 0.0625 mg/litre up to 100%, LC50 (24 hours) that spiral shell is killed at spiral shell 24 hours, and 50% bayluscid can
LC50 (24 hours) of wet powder are 0.1250 mg/litre, LC50 (24 hours) of 1% methaldehyde suspending agent for greater than
0.5 mg/litre, bayluscid compounding suspending agent have preferable molluscicidal effect (table 2).
Oncomelania effect is killed in the leaching of 2 laboratory of table
Embodiment 7:
Scene leaching kills oncomelania effect selection Nanjing Qixia District and carries out live spraying molluscicide, by baseline visit, chooses oncomelania
The snail habitat of 10/frame of density > (0.1m2), is divided into 5 cells, and each cell about 100m2 is removed and is higher than in cell
The weeds of 5cm simultaneously remove trial zone.Wherein 3 cells are experimental group, and 3 product of Example presses 4.0,2.0 and 1.0g/m respectively2
Drug is sprayed, 1 cell is 50% Niclosamide ethanolamine salt wettable powder agent 2.0g/m of drug control group2, 1 cell is sky
White control group.1,3 and 7d of Shi Yuehou investigates oncomelania with the checkerboard type methods of sampling, extracts respectively in each trial zone and check plot
10 frames are captured whole oncomelanias in frame, are wrapped as unit of frame with paper bag, and record number, capture spiral shell number etc. return indoor clear water punching
It washes, after 48h restores raising, identifies Death of Oncomelania Snails number and survival number with hammering method.Compounding suspending agent, which has, as the result is shown preferably kills
Spiral shell effect (table 3).
Spiral shell test result is killed in 3 scene sprinkling of table
The above result shows that calculating by the effective dose of bayluscid compounding suspending agent, suspending agent is being used
2.0g/m2When (effective dose 1.0g/m2), it can reach 50% bayluscid 2.0g (i.e. effective dose 1.0g/m2)
Molluscicidal effect, i.e. dosage halve, and can achieve equivalent effect.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. a kind of preparation method of colloidal suspending agent, which is characterized in that including being activity with bayluscid and the methaldehyde
Ingredient, is aided with auxiliary material pesticide-acceptable, and auxiliary material includes wetting agent 1~5%, dispersing agent 1~20%, antifreezing agent 1~10%,
Preservative 0.1~1%, pH adjusting agent 0.1~1%, defoaming agent 0.1~1%, thickener 0.1~2%, deionized water complements to
100%, above-mentioned each component be can be prepared by into aqueous suspension agent by being ground to 1~10um after mixing；Wherein niclosamidum second
The mass ratio of alcohol amine salt and the methaldehyde is 1~50: 1~10.
2. a kind of preparation method of colloidal suspending agent according to claim 1, which is characterized in that the colloidal suspending agent is with niclosamidum
Ethanolamine salt and the methaldehyde are active constituent, are aided with auxiliary material pesticide-acceptable and emulsion, water dispersible granules is made.
3. a kind of preparation method of colloidal suspending agent according to claim 1, which is characterized in that the bayluscid
Content be 1~50%, the methaldehyde content be 1~5%.
4. a kind of preparation method of colloidal suspending agent according to claim 1, which is characterized in that the wetting agent is selected from dodecane
Base sodium sulphate, pull open powder, alkyl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, aliphatic acid polyethenoxy ether, in alkyl glycosides
One or more.
5. a kind of preparation method of colloidal suspending agent according to claim 1, which is characterized in that the dispersing agent is selected from methylene
One of double sodium naphthalene sulfonates, lignosulfonates, polycarboxylate sodium, alkyl phenol polyoxyethylene ether phosphate, speed pool 270 are several
Kind.
6. a kind of preparation method of colloidal suspending agent according to claim 1, which is characterized in that the antifreezing agent is selected from second two
One or more of alcohol, glycerine, urea, sodium chloride；The preservative selects one of sodium benzoate, Kathon CG, formaldehyde
Or it is several；The pH adjusting agent is selected from one or more of benzoic acid, glacial acetic acid, citric acid, hydrochloric acid；The defoaming agent is selected from
One or more of organic silicone, polyethers, butanol；The thickener is selected from xanthan gum, gelatin, Arabic gum, bentonite, silicon
One or more of sour magnalium.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811361681.9A CN109380226A (en) | 2018-11-15 | 2018-11-15 | A kind of preparation method of colloidal suspending agent |
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| CN201811361681.9A CN109380226A (en) | 2018-11-15 | 2018-11-15 | A kind of preparation method of colloidal suspending agent |
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| CN109380226A true CN109380226A (en) | 2019-02-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11324708B1 (en) * | 2020-04-01 | 2022-05-10 | UNION therapeutics A/S | Niclosamide formulations for treating disease |
-
2018
- 2018-11-15 CN CN201811361681.9A patent/CN109380226A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11324708B1 (en) * | 2020-04-01 | 2022-05-10 | UNION therapeutics A/S | Niclosamide formulations for treating disease |
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