CN109371760A - 一种预防痔疮和肛裂的中药卫生纸 - Google Patents
一种预防痔疮和肛裂的中药卫生纸 Download PDFInfo
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Abstract
本发明属于生活用纸技术领域,具体涉及一种预防痔疮和肛裂的中药卫生纸及其制备方法。本发明以中医学治疗痔疮的理论为依据,并综合考虑中药材的构造特点,提供了完全使用中药自身的纤维作为纸浆原料的方法,选择具有清热解毒,凉血止血作用,且富含植物纤维的芦根,地榆,地锦草,铁苋菜,苦参,甘草六味中药制备卫生纸,为避免所含有效成分被破坏,首先将各药材经水提醇沉后,将药渣制成纸浆原料,再加入提取药液,制成中药卫生纸。实验研究表明,本发明中的中药卫生纸可以对痔疮和肛裂起到一定防治作用。此外,由于将中药自身的纤维用做纸浆原料,预计生产每吨卫生纸可节约木浆纤维0.2~0.5吨,从而可减少林木资源的消耗,有利于环境保护。
Description
技术领域
本发明属于生活用纸技术领域,具体涉及一种预防痔疮和肛裂的中药卫生纸及其制备方法。
背景技术
痔疮和肛裂为临床常见病、多发病,患者以中青年为主,由于发病部位隐秘,治疗多有不便。中医药治疗痔疮和肛裂有良好效果,但口服用药顺应性差,外用熏洗操作不便。卫生纸是日常生活中的必用品,将中药加入至卫生纸中,痔疮和肛裂患者使用卫生纸时药物可作用于患处,使用方便而且可起到一定预防作用,具有较好的可行性和市场前景。而目前相关文献报道中,加入中药的卫生纸在制备过程中仍需以木浆纤维作为纸浆原料(如申请号为201210493363.4的专利“防痔疮卫生纸制造方法”,申请号为201510683533.9的专利“一种防痔疮卫生纸的制备方法”,申请号为201711124532.6的专利“一种防肛裂防痔疮卫生纸”)。卫生纸大量使用木浆纤维会对森林资源造成威胁,不利于环境保护,因此在制备工艺上仍有待创新。
发明内容
鉴于现有技术存在的缺陷,本发明的目的是提供一种预防痔疮和肛裂的中药卫生纸及其制备方法。以中医学治疗痔疮的理论为依据,并综合考虑中药材的构造特点,选择具有清热解毒,凉血止血作用,且富含植物纤维的芦根,地榆,地锦草,铁苋菜,苦参,甘草六味中药制备卫生纸,不仅可以对痔疮和肛裂起到一定防治作用,还可将药材本身所含有的植物纤维用做纸浆原料,从而减少林木资源的消耗,有利于环境保护。
为实现本发明的目的,采用以下技术方案。
一种预防痔疮和肛裂的中药卫生纸,由以下重量份的成分组成:芦根1 ~ 100份,地榆1 ~ 50份,地锦草1 ~ 50份,铁苋菜1 ~ 50份,苦参1 ~ 50份,甘草1 ~ 30份。
进一步地所述预防痔疮和肛裂的中药卫生纸,由以下重量份的成分组成:芦根50份、地榆20份、地锦草20份、铁苋菜20份、苦参50份、甘草10份。
进一步地所述预防痔疮和肛裂的中药卫生纸,由以下重量份的成分组成:芦根100份、地榆50份、地锦草10份,铁苋菜10份,苦参10份、甘草10份。
一种预防痔疮和肛裂的中药卫生纸,其制备方法具体包括以下步骤。
1)药液提取工艺: 按照重量比例称取芦根、地榆、地锦草、铁苋菜、苦参和甘草,混匀,装入多功能提取罐,加入药材重量6 ~ 12倍量(V/W)的水,沸腾提取15 ~ 60分钟,分离提取液,60 ℃减压浓缩至药液相对密度达1.0 ~ 1.2,加入95 %乙醇搅匀,使含醇量达60 ~80 %,静置12 ~ 24小时,过滤,上清液60 ℃减压浓缩至无乙醇味,浓缩后的药液备用。
2) 纸浆制备工艺:药渣置蒸球中加入2 ~ 4倍量(V/W)0.1 mol/L的氢氧化钠溶液,80 ~ 100 ℃加热处理1 ~ 5小时,至粗浆硬度(K值)为8 ~ 15,滤过,滤渣水洗至pH 7.0~ 7.5,备用。
3) 纸浆中加入中药的工艺:取浓缩后的药液,加水稀释至药渣重量的8 ~ 15倍(V/W),静置12 ~ 24小时,过滤,上清液加至碎浆机中,再投入药渣,碎解10 ~ 60分钟,得到打浆度为30 ~ 40 ºSR的浆料。抽取浆料,经除砂器滤除杂质后,加入磨浆机磨浆,研磨后的浆料导入抄纸机,经喷嘴喷射至网笼成型,烘缸干燥至卫生纸含水量为4.0 ~ 10.0 %,烘缸蒸汽压力1.0 ~ 2.0 MPa,蒸汽温度140 ~ 210 ℃,干燥后的卫生纸使用卷纸机卷纸,切刀切制,即得。
与现有技术比,本发明的有益效果如下。
(1)本发明中的中药卫生纸,在用药选择时充分考虑了中医学治疗痔疮的理论依据,如金元四大家中的朱震亨认为:“痔疮专以凉血为主”(出自《丹溪心法》),刘完素认为:“当泻三焦,火热退,使金得气而反制木,木受制则五虫不生,痔有愈矣”(《出自河间医学·痔论》)。因此选择具有寒凉药性,有清热凉血功效的中药作为卫生纸的原料,其中芦根可清热泻火,苦参能清热燥湿,地榆凉血止血、解毒敛疮,地锦草和铁苋菜清热解毒、凉血止血,甘草清热解毒、调和诸药,六药配伍,共同发挥清热解毒、凉血止血的作用,可对湿热下注、风伤肠络所致痔疮和肛裂起到一定防治作用,且使用方便。
(2)本发明中的中药卫生纸使用的中药材均富含植物纤维,将提取后的中药药渣制成纸浆原料,无需再使用木浆纤维,与现有报道的同类产品相比,预计生产每吨卫生纸可节约木浆纤维0.2 ~ 0.5吨,从而减少林木资源的消耗,有利于环境保护。
(3)本发明中的中药卫生纸在制备过程中,先使用水提醇沉法对中药材进行提取纯化,再将提取后的药渣使用碱水蒸煮脱木素制得纸浆原料,最后再将提取药液与纸浆原料混合打浆,可避免药材中有效成分在碱水蒸煮过程中被破坏,保留其功效作用。
具体实施方式
下面结合具体实施例对本发明进行进一步描述说明,但本发明的保护范围并不仅限于此。
实施例1。
(1)卫生纸制备:按照重量比例称取芦根50份、苦参50份、地榆20份、地锦草20份,铁苋菜20份,甘草10份,混匀,装入多功能提取罐,加入药材重量10倍量(V/W)的水,沸腾提取30分钟,分离提取液,60 ℃减压浓缩至药液相对密度达1.1,加入95 %乙醇搅匀,使含醇量达70 %,静置12小时,过滤,上清液60 ℃减压浓缩至无乙醇味,浓缩后的药液备用。
药渣置蒸球中加入2.5倍量(V/W)0.1 mol/L的氢氧化钠溶液,85 ℃加热处理3小时,至粗浆硬度(K值)为9 ~ 11。滤过,滤渣水洗至pH 7.0 ~ 7.5,备用。
取浓缩后的药液,加水稀释至药渣重量的10倍(V/W),静置12小时,过滤,上清液加至碎浆机中,再投入药渣,碎解25分钟,得到打浆度为30 ~ 40 ºSR的浆料。抽取浆料,经除砂器滤除杂质后,加入磨浆机磨浆,研磨后的浆料导入抄纸机,经喷嘴喷射至网笼成型,烘缸干燥至卫生纸含水量为7.5 %,烘缸蒸汽压力1.0 MPa,蒸汽温度160 ℃。干燥后的卫生纸使用卷纸机卷纸,切刀切制,即得。
(2)组方依据:处方中芦根可清热泻火,苦参能清热燥湿,二者共为君药;地榆凉血止血、解毒敛疮,地锦草、铁苋菜清热解毒、凉血止血,三者共为臣药;甘草清热解毒、调和诸药,为佐使药。六药配伍,共同发挥清热燥湿、凉血止血的功效,适于治疗湿热下注所致痔疮。
(3)使用效果:张某,男,42岁。患痔疮5年,便时常出现滴血或手纸上带血,进食辛辣刺激性食物后加重。使用本实施例制备的卫生纸4周后,便血停止,使用3个月后,未发现便血现象。
实施例2。
(1)卫生纸制备:按照重量比例称取芦根100份、地榆50份、地锦草10份,铁苋菜10份,苦参10份、甘草10份,混匀,装入多功能提取罐,加入药材重量10倍量(V/W)的水,沸腾提取30分钟,分离提取液,60 ℃减压浓缩至药液相对密度达1.1,加入95 %乙醇搅匀,使含醇量达70 %,静置12小时,过滤,上清液60 ℃减压浓缩至无乙醇味,浓缩后的药液备用。
药渣置蒸球中加入3倍量(V/W)0.1 mol/L的氢氧化钠溶液,90 ℃加热处理3小时,至粗浆硬度(K值)为9 ~ 11。滤过,滤渣水洗至pH 7.0 ~ 7.5,备用。
取浓缩后的药液,加水稀释至药渣重量的10倍(V/W),静置12小时,过滤,上清液加至碎浆机中,再投入药渣,碎解25分钟,得到打浆度为30 ~ 40 ºSR的浆料。抽取浆料,经除砂器滤除杂质后,加入磨浆机磨浆,研磨后的浆料导入抄纸机,经喷嘴喷射至网笼成型,烘缸干燥至卫生纸含水量为6.5 %,烘缸蒸汽压力2.0 MPa,蒸汽温度205 ℃。干燥后的卫生纸使用卷纸机卷纸,切刀切制,即得。
(2)组方依据:处方中芦根可清热泻火,地榆能凉血止血、解毒敛疮,二者共为君药;地锦草、铁苋菜清热解毒、凉血止血,苦参清热燥湿,三者共为臣药;甘草清热解毒,调和诸药,为佐使药。六药配伍,共同发挥清热解毒、凉血止血的功效,适于治疗风伤肠络所致肛裂、痔疮。
(3)使用效果:周某,女,42岁。患肛裂3年,便秘时常出现便血,血色鲜红。使用本实施例制备的卫生纸2周后,症状减轻,使用3个月后,未发现便血现象。张某,女,45岁。患肛裂及痔疮4年,便秘时常出现便血,血色鲜红。使用本实施例制备的卫生纸2周后,症状减轻,使用6个月后,偶现便血现象。
实施例3 本发明中药卫生纸促进肛周创面愈合作用的药理实验。
参照《中药痔疮动物模型制备规范(草案)》(中华中医药学会中药实验药理专业委员会制订,中药药理与临床,2017,33(5):211-212)要求,取SPF级KM小鼠15只,随机分为三组:对照组,中药卫生纸A组,中药卫生纸B组,每组5只,用手术刀在小鼠右侧臀尾肛门部沿菱形模板(S = 1 cm×0.5 cm)制备一个急性、开放、渗血、沾染创面,经24小时后确认造模成功,中药卫生纸A组小鼠使用实施例1中制备的卫生纸擦拭创伤面,中药卫生纸B组小鼠使用实施例2中制备的卫生纸擦拭创伤面,对照组使用不含中药的普通卫生纸擦拭创面,每次使用4 cm2面积卫生纸,每天擦拭三次,观察创面愈合情况,记录愈合时间,单因素方差分析计算统计学差异,结果见表1。
结果显示,中药卫生纸A组和B组小鼠肛周创面愈合时间较对照组明显缩短,表明本发明所制备的中药卫生纸具有较好的促进肛周创面愈合的作用,在防治痔疮、肛裂方面具有良好应用前景。
Claims (4)
1.一种预防痔疮和肛裂的中药卫生纸,其特征在于,由以下重量份的成分组成:芦根1~ 100份,地榆1 ~ 50份,地锦草1 ~ 50份,铁苋菜1 ~ 50份,苦参1 ~ 50份、甘草1 ~ 30份。
2.根据权利要求1所述的预防痔疮和肛裂的中药卫生纸,其特征在于,由以下重量份的成分组成:芦根50份、地榆20份、地锦草20份、铁苋菜20份、苦参50份、甘草10份。
3.根据权利要求1所述的预防痔疮和肛裂的中药卫生纸,其特征在于,由以下重量份的成分组成:芦根100份、地榆50份、地锦草10份,铁苋菜10份、苦参10份、甘草10份。
4.一种预防痔疮和肛裂的中药卫生纸的制备方法,其特征在于,具体包括以下步骤:
1)药液提取工艺: 按照重量比例称取芦根、地榆、地锦草、铁苋菜、苦参和甘草,混匀,装入多功能提取罐,加入药材重量6 ~ 12倍量(V/W)的水,沸腾提取15 ~ 60分钟,分离提取液,60 ℃减压浓缩至药液相对密度达1.0 ~ 1.2,加入95 %乙醇搅匀,使含醇量达60 ~ 80%,静置12 ~ 24小时,过滤,上清液60 ℃减压浓缩至无乙醇味,浓缩后的药液备用;
2)纸浆制备工艺:药渣置蒸球中加入2 ~ 4倍量(V/W)0.1 mol/L的氢氧化钠溶液,80 ~100 ℃加热处理1 ~ 5小时,至粗浆硬度(K值)为8 ~ 15,滤过,滤渣水洗至pH 7.0 ~ 7.5,备用;
3)浆中加入中药的工艺:取浓缩后的药液,加水稀释至药渣重量的8 ~ 15倍(V/W),静置12 ~ 24小时,过滤,上清液加至碎浆机中,再投入药渣,碎解10 ~ 60分钟,得到打浆度为30 ~ 40 ºSR的浆料,抽取浆料,经除砂器滤除杂质后,加入磨浆机磨浆,研磨后的浆料导入抄纸机,经喷嘴喷射至网笼成型,烘缸干燥至卫生纸含水量为4.0 ~ 10.0 %,烘缸蒸汽压力1.0 ~ 2.0 MPa,蒸汽温度140 ~ 210 ℃,干燥后的卫生纸使用卷纸机卷纸,切刀切制,即得。
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