CN109364164A - A kind of aloe repairs peptide gel and preparation method thereof - Google Patents

A kind of aloe repairs peptide gel and preparation method thereof Download PDF

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Publication number
CN109364164A
CN109364164A CN201811519551.3A CN201811519551A CN109364164A CN 109364164 A CN109364164 A CN 109364164A CN 201811519551 A CN201811519551 A CN 201811519551A CN 109364164 A CN109364164 A CN 109364164A
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accounting
aloe
phenoxyethanol
preparation
extract solution
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陈华
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Shanghai Meiha Pharmaceutical Technology Co Ltd
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Shanghai Meiha Pharmaceutical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/742Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/886Aloeaceae (Aloe family), e.g. aloe vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Natural Medicines & Medicinal Plants (AREA)
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  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention discloses a kind of aloes to repair peptide gel and preparation method thereof, comprising: carbomer, deionized water, Phenoxyethanol, lavender flavor type, extract solution from aloe body, poly hexamethylene biguanide and fermentation of bacillus product.As a preferred technical solution of the present invention, this kind of the carbomer accounting 1%, the deionized water accounting 97.72%, the Phenoxyethanol accounting 0.2%, the lavender flavor type accounting 0.01%, the extract solution from aloe body accounting 0.07%, the poly hexamethylene biguanide accounting 0.5% and the fermentation of bacillus product accounting 0.5% aloe repair peptide gel and preparation method thereof.Raw material Phenoxyethanol has disinfection, anti-corrosion, has stronger killing effect to Pseudomonas aeruginosa;Lavender flavor type can go peculiar smell, extract solution from aloe body to have unique reparation, effects of antiinflammation and bacteriostasis, the symptoms such as can relieve pain, itch, is rubescent, can promote the healing of wound, and toxin-expelling and face nourishing repairs injured cell;Poly hexamethylene biguanide has the extremely strong ability for killing bacterium.

Description

A kind of aloe repairs peptide gel and preparation method thereof
Technical field
The present invention relates to pharmaceutical technology fields, repair peptide gel and preparation method thereof more particularly, to a kind of aloe.
Background technique
Skin be human body area it is maximum and most directly with the external world contact tissue, while be also be most susceptible to environmental stimuli And the organ damaged.The healing of normal wound is most important to maintenance body stable state, and exception heals as large area burn and scald is made At not more or late more, the shape of Promote Chronic Ischemic Wound Healing caused by other diseases and abnormal healing such as pathologic scar At etc. not only affect beauty, the obstacle of structure and function but will be caused, heavy psychological pressure is often caused to patient, sternly The physical and mental health of patient is affected again.Therefore, how it to be rapidly achieved optimal healing effect in skin wound treatment, is always people The hot spot studied.After the tissue of body incurs loss, except can not be outside the extraneous such as age objective factor intervened, from increase The nutrition supply of damaged part, using pharmaceutical intervention, it promotes survivaling cell proliferation, promotes the new life of capillary and nerve thin The regeneration etc. of born of the same parents, can accelerate the reparation of tissue.
Modern society people can select to repair peptide mostly to repair sensitive skin.Peptide is repaired in beauty treatment skin surgical postoperative skin Skin nursing in using primary product: repair peptide select product: skin beauty relax, the tender face essence application method of moisturizing: postoperative skin After cleaning, first using reparation peptide;Such as skin have it is red, itch, dry malaise symptoms add relaxed with the tender face essence of moisturizing and skin beauty again.It repairs Multiple peptide improve in the poor skin nursing of skin quality that is easily sensitive, thering is red capillary to show using primary product: repair peptide, moisturizing Tender face essence, skin beauty Shu Xuanyong product: tender face moisturizing mildy wash, tender face skin-moisturizing, skin water, aloe Shu Min powder for soft mask user Method: clean skin, conditioning use after facial mask;It first uses and repairs peptide, then relaxed with the tender face essence of moisturizing and skin beauty.Effect explanation: add Fast epidermal renewal repairs skin barrier defencive function, fundamentally improves the poor situation of skin quality.Prevent skin photoage, it is main Dynamic implicit damage after repairing solarization.Skin moisturizing degree is persistently kept, the elimination dry and astringent state of skin, improves skin water shortage and bring is wrinkled Line repairs dry skin water shortage and bring implicit damage.A neck delicacy epidermal tissue can be activated by repairing peptide, dispel black eye Circle, keeps skin of neck compact delicate at eye wrinkle-removing
However, cosmetics belong to fine chemical product, raw material is mostly artificial synthesized or modified chemical products, antigen Property and to the bad control of the suitable dosage of human body, after usage, skin will appear the skins such as itch, redness, drying to groups of people Inflammation.Currently, many kinds of of peptide gelling agent is repaired on the market, and the effect antibacterial for treatment is irregular, function list One, there are significant limitations for many reparation peptide gelling agent product bacteriostasis, therefore it provides one kind can sterilize, is antipruritic And anti-inflammatory, the aloe that can also repair wound repair peptide gel
Summary of the invention
The technical problem to be solved by the present invention is to overcome the existing defects, provides a kind of aloe and repairs peptide gel and its preparation Method, to solve the above problems.
To achieve the above object, the invention provides the following technical scheme: a kind of aloe repair peptide gel, including below at Point: carbomer, deionized water, Phenoxyethanol, lavender flavor type, extract solution from aloe body, poly hexamethylene biguanide and bacillus Tunning, the carbomer accounting 1%, the Phenoxyethanol accounting 0.2%, described smoke the deionized water accounting 97.72% Clothing hay-scented type accounting 0.01%, the extract solution from aloe body accounting 0.07%, the poly hexamethylene biguanide accounting 0.5% and described Fermentation of bacillus product accounting 0.5%.
As a preferred technical solution of the present invention, the extract solution from aloe body is obtained by the water of 1 gram of powder dilution 100ml It arrives.
The present invention also provides the preparation methods that a kind of aloe repairs peptide gel, include the following steps;
Step 1;Prepare material: proportionally preparing: 1%, two part of deionized water accounting 92.72% of the carbomer accounting With 5%, the Phenoxyethanol accounting 0.2%, the lavender flavor type accounting 0.01%, the extract solution from aloe body accounting 0.07%, The poly hexamethylene biguanide accounting 0.5% and the fermentation of bacillus product accounting 0.5%;
Step 2: the powder of 1 gram of addition dilutes and obtains the extract solution from aloe with the water of 100ml, first gets sample, then squeezes out It has some on paper handkerchief, tests repeatedly, some colors cannot be stayed on paper handkerchief, as standard;0.01% lavender flavor type is first Some samples are got, confirm specifically to match, as long as a little light faint scent is smelt, as standard
Step 3;In a reservoir by the deionized water 92.72%, the Phenoxyethanol, the lavender flavor type, the aloe Extracting liq is proportionally added into, and is stirring evenly and then adding into the carbomer, then is stirred uniformly, and mixing time is not below 1 A hour;
Step 4;5% ionized water for taking 50 degree, proportionally by poly hexamethylene biguanide and fermentation of bacillus product card wave It is added in ionized water and dissolves, stir evenly;
Step 5: it is stirred evenly in the step of step four dissolved is finally added to front three;
Step 6;The product formed after being uniformly mixed is sealed encapsulation.
A kind of optimal technical scheme that the preparation method of peptide gel is repaired as a kind of aloe of the present invention, mixed liquor is carried out It examines, qualification is examined to be sealed packaging.
A kind of optimal technical scheme that the preparation method of peptide gel is repaired as a kind of aloe of the present invention, in preparation process In, the pH value of solution controls the intercaste in 6.5-7.
Compared with prior art, the beneficial effects of the present invention are: this kind of aloe repairs peptide gel and preparation method thereof, raw material Phenoxyethanol has disinfection, anti-corrosion, has stronger killing effect to Pseudomonas aeruginosa;Lavender flavor type can remove peculiar smell, and aloe mentions Take liquid have it is unique repair, anti-inflammatory is antibacterial and bactericidal effect, can promote that healing heart tonifying promoting blood circulation is immune and regeneration, removing toxic substances are made With anti-aging effects can promote the healing of wound, and toxin-expelling and face nourishing repairs injured cell;Poly hexamethylene biguanide has extremely strong The ability of bacterium is killed, and efficiently and is played the role of long-term antibacterial;It has no toxic side effect;Preparation process is simple, in use, will coagulate Glue is applied to skin affected part, and softly skin is promoted to absorb.
Specific embodiment
Technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is only It is a part of the embodiment of the present invention, instead of all the embodiments, based on the embodiments of the present invention, ordinary skill people Member's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
The present invention provides a kind of technical solution: a kind of aloe reparation peptide gel, including following component: carbomer, deionization Water, Phenoxyethanol, lavender flavor type, extract solution from aloe body, poly hexamethylene biguanide and fermentation of bacillus product.
The carbomer accounting 1%, the Phenoxyethanol accounting 0.2%, described smokes clothing at the deionized water accounting 97.72% Hay-scented type accounting 0.01%, the extract solution from aloe body accounting 0.07%, the poly hexamethylene biguanide accounting 0.5% and the bud Spore bacillus fermentation product accounting 0.5%.
The extract solution from aloe body is obtained by the water of 1 gram of powder dilution 100ml.
Include the following steps;
Step 1;Prepare material: proportionally preparing: 1%, two part of deionized water accounting 92.72% of the carbomer accounting With 5%, the Phenoxyethanol accounting 0.2%, the lavender flavor type accounting 0.01%, the extract solution from aloe body accounting 0.07%, The poly hexamethylene biguanide accounting 0.5% and the fermentation of bacillus product accounting 0.5%;
Step 2: the powder of 1 gram of addition dilutes and obtains the extract solution from aloe with the water of 100ml, first gets sample, then squeezes out It has some on paper handkerchief, tests repeatedly, some colors cannot be stayed on paper handkerchief, as standard;0.01% lavender flavor type is first Some samples are got, confirm specifically to match, as long as a little light faint scent is smelt, as standard
Step 3;In a reservoir by the deionized water 92.72%, the Phenoxyethanol, the lavender flavor type, the aloe Extracting liq is proportionally added into, and is stirring evenly and then adding into the carbomer, then is stirred uniformly, and mixing time is not below 1 A hour;
Step 4;5% ionized water for taking 50 degree, proportionally by poly hexamethylene biguanide and fermentation of bacillus product card wave It is added in ionized water and dissolves, stir evenly;
Step 5: it is stirred evenly in the step of step four dissolved is finally added to front three;
Step 6;The product formed after being uniformly mixed is sealed encapsulation.
Mixed liquor is tested, qualification is examined to be sealed packaging.
During the preparation process, the pH value of solution controls between 6.5-7.
Concrete principle: by the disinfection of raw material Phenoxyethanol, anti-corrosion, there is stronger killing effect to Pseudomonas aeruginosa;Smoke clothing Hay-scented type can remove peculiar smell, and extract solution from aloe body has unique reparation, effects of antiinflammation and bacteriostasis, can relieve pain, itches, send out The symptoms such as red, can promote the healing of wound, and toxin-expelling and face nourishing repairs injured cell;Poly hexamethylene biguanide has extremely strong killing The ability of bacterium, and efficiently and play the role of long-term antibacterial;It is pressed again with carbomer, deionized water and fermentation of bacillus product Gel is applied to affected part after being mixed according to ratio.
This kind of aloe repairs peptide gel and preparation method thereof, and raw material Phenoxyethanol has disinfection, anti-corrosion, has to Pseudomonas aeruginosa Stronger killing effect;Lavender flavor type can remove peculiar smell;Extract solution from aloe body has unique reparation, anti-inflammatory antibacterial and sterilization Effect can promote healing heart tonifying promoting blood circulation and be immunized and regenerate, detoxication, anti-aging effects, can promote the healing of wound, toxin expelling is supported Face repairs injured cell;Poly hexamethylene biguanide has the extremely strong ability for killing bacterium, and efficiently and has long-term antibacterial Effect;It has no toxic side effect;Preparation process is simple, in use, gel is applied to skin affected part, and softly skin is promoted to absorb.
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention, Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features, All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention Within protection scope.

Claims (5)

1. a kind of aloe repairs peptide gel, which is characterized in that including following component: carbomer, Phenoxyethanol, smokes deionized water Clothing hay-scented type, extract solution from aloe body, poly hexamethylene biguanide and fermentation of bacillus product, it is the carbomer accounting 1%, described Deionized water accounting 97.72%, the Phenoxyethanol accounting 0.2%, the lavender flavor type accounting 0.01%, the aloe are extracted Liquid accounting 0.07%, the poly hexamethylene biguanide accounting 0.5% and the fermentation of bacillus product accounting 0.5%.
2. a kind of aloe according to claim 1 repairs peptide gel, which is characterized in that the extract solution from aloe body is by 1 gram Powder dilution 100ml water obtain.
3. the preparation method that a kind of aloe repairs peptide gel, which is characterized in that include the following steps;
Step 1;Prepare material: proportionally preparing: 1%, two part of deionized water accounting 92.72% of the carbomer accounting With 5%, the Phenoxyethanol accounting 0.2%, the lavender flavor type accounting 0.01%, the extract solution from aloe body accounting 0.07%, The poly hexamethylene biguanide accounting 0.5% and the fermentation of bacillus product accounting 0.5%;
Step 2: the powder of 1 gram of addition dilutes and obtains the extract solution from aloe with the water of 100ml, first gets sample, then squeezes out It has some on paper handkerchief, tests repeatedly, some colors cannot be stayed on paper handkerchief, as standard;0.01% lavender flavor type is first Some samples are got, confirm specifically to match, as long as a little light faint scent is smelt, as standard
Step 3;In a reservoir by the deionized water 92.72%, the Phenoxyethanol, the lavender flavor type, the aloe Extracting liq is proportionally added into, and is stirring evenly and then adding into the carbomer, then is stirred uniformly, and mixing time is not below 1 A hour;
Step 4;5% ionized water for taking 50 degree, proportionally by poly hexamethylene biguanide and fermentation of bacillus product card wave It is added in ionized water and dissolves, stir evenly;
Step 5: it is stirred evenly in the step of step four dissolved is finally added to front three;
Step 6;The product formed after being uniformly mixed is sealed encapsulation.
4. the preparation method that a kind of aloe according to claim 3 repairs peptide gel, which is characterized in that carry out mixed liquor It examines, qualification is examined to be sealed packaging.
5. the preparation method that a kind of aloe according to claim 3 repairs peptide gel, which is characterized in that in preparation process In, the pH value of solution controls between 6.5-7.
CN201811519551.3A 2018-12-12 2018-12-12 A kind of aloe repairs peptide gel and preparation method thereof Pending CN109364164A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110179839A (en) * 2019-07-03 2019-08-30 上海美哈医药科技有限公司 A kind of anti-myomata gelling agent and preparation method thereof
CN110179840A (en) * 2019-07-03 2019-08-30 上海美哈医药科技有限公司 A kind of cordyceps sinensis vagina anti-immunity bacteriostatic agent and preparation method thereof

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CN105687012A (en) * 2014-11-28 2016-06-22 青岛首冠企业管理咨询有限公司 Aloe moisture-retention facial-cleaning gel
CN107616956A (en) * 2017-11-16 2018-01-23 云南天美天康生物科技有限公司 A kind of aloe skin care compositions and preparation method thereof
CN107683869A (en) * 2017-09-12 2018-02-13 吴晓军 A kind of biological bacteriostatic gel
CN108498345A (en) * 2018-04-23 2018-09-07 珠海国佳新材股份有限公司 A kind of gel adhesive and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN103785055A (en) * 2012-10-26 2014-05-14 范敏华 Scar healing and moisturizing gel, and preparation method thereof
CN105687012A (en) * 2014-11-28 2016-06-22 青岛首冠企业管理咨询有限公司 Aloe moisture-retention facial-cleaning gel
CN107683869A (en) * 2017-09-12 2018-02-13 吴晓军 A kind of biological bacteriostatic gel
CN107616956A (en) * 2017-11-16 2018-01-23 云南天美天康生物科技有限公司 A kind of aloe skin care compositions and preparation method thereof
CN108498345A (en) * 2018-04-23 2018-09-07 珠海国佳新材股份有限公司 A kind of gel adhesive and preparation method thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110179839A (en) * 2019-07-03 2019-08-30 上海美哈医药科技有限公司 A kind of anti-myomata gelling agent and preparation method thereof
CN110179840A (en) * 2019-07-03 2019-08-30 上海美哈医药科技有限公司 A kind of cordyceps sinensis vagina anti-immunity bacteriostatic agent and preparation method thereof

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Application publication date: 20190222