CN109363732A - A kind of hand hay cutter head device for acute cerebral hypoxia pharmacological evaluation - Google Patents
A kind of hand hay cutter head device for acute cerebral hypoxia pharmacological evaluation Download PDFInfo
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- CN109363732A CN109363732A CN201811164895.7A CN201811164895A CN109363732A CN 109363732 A CN109363732 A CN 109363732A CN 201811164895 A CN201811164895 A CN 201811164895A CN 109363732 A CN109363732 A CN 109363732A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B16/00—Devices specially adapted for vivisection or autopsy
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Abstract
The present invention provides it is a kind of for acute cerebral hypoxia experiment hand hay cutter head device comprising component have: (1) cuboid of one groove of band one；(2) one section of hollow pipe；(3) one, chopper.The assembly and connection mode of the component are as follows: hollow pipe is horizontally placed on cuboid groove one end, and fits closely with groove, hollow pipe broken ends of fractured bone edge and groove broken ends of fractured bone coincident, and fits closely with chopper fixed edge notch.The component specification are as follows: 4~1000 centimetres of the length of cuboid, it is 10~15 centimetres wide, it is 8~15 centimetres high；The length of cuboid upper groove is 10~15 centimetres, and width is 3~4 centimetres, and depth is 2~4 centimetres；3 ~ 10 centimetres of hollow pipe diameter, 5~10 centimetres of length；Chopper band pedestal, fixed edge, movable edge band blade, upper lower edge blade are unfolded into pass, and pass diameter is 4 ~ 10 centimetres, and fixed edge height is 6 ~ 12 centimetres.The present invention can solve animal hand hay cutter head anxiety struggle or laboratory technician's problem of biting, and the blood oxygen loss before reducing experimental animal hand hay cutter head to greatest extent, experimental error caused by avoiding experimental animal from struggling in various degree makes experimental implementation specification, and it is reliable that experimental data is credible.Operation of the present invention is convenient, and making material is low in cost, is suitble to promote and apply.
Description
Technical field
The invention belongs to pharmacological evaluation instrument fields, and in particular to a kind of hand hay cutter head dress for acute cerebral hypoxia pharmacological evaluation
It sets.
Background technique
The experiment of body anoxia endurance is common method of evaluating drug effect, according to different anoxic production principles, is contained
Oxygen deficit tolerance experiment, the experiment of sodium nitrite poisoning anoxic, acute cerebral hypoxia experiment.It is resistance to body anoxic in drug or health care product
In the experiment of stress evaluation of effect, usually requires that while carrying out these three experiments with its action principle of pre-test and the experiment knot that corroborates each other
The reliability of fruit.
Acute cerebral hypoxia experiment is after cutting up with a hay cutter head according to experimental animal, and brain blood supply terminates suddenly, in a short time original blood
Interior oxygen and nutriment can still maintain the vital movement principle of brain, show regular mouth breathing after experimental animal hand hay cutter head,
Using the time of wheezing as index, observable goes out protective effect of the drug to Acute cerebral ischemia anoxic.It is all to make the reduction of brain oxygen demand
Or the drug that the oxygen content of blood increases, it can extend animal and wheeze the time.
Acute cerebral hypoxia experimental method are as follows: after experimental animal is administered, places in quiet environment and stand 30 minutes, take
Object cuts up with a hay cutter head, and the immediate record experimental animal mouth breathing time, finally statistical analysis experiment groups of animals breathing time, evaluation should
Drug acts on acute cerebral hypoxia tolerance.
Applicant is not retrieved by literature search about experiment hand hay cutter head device report, according to 22 years pharmacology of inventor
Experiment working experience and colleague's academic exchange learn that hand hay cutter head method used at present mainly has: laboratory technician's hand grabs experimental mouse, cuts
Knife broken end；Laboratory technician's hand grabs experimental mouse, and chopper cuts up with a hay cutter head.
We have found in practice operation, no matter with that method, all refer in one's hands grab experimental animal.Experimental animal by
When grabbing stimulation to the hands of different dynamics, the risk of different anxieties, fear and struggle and the laboratory technician that bites, internal blood can be generated
Oxygen is lost in various degree with amount of exercise increase, and the increased blood oxygen concentration of drug or the effect of reduced Tissue oxygen consumption are disturbed,
It is big to eventually lead to experimental data variance, scientific objectively statistical analysis can not be carried out.
Therefore, a kind of experiment instrument completion hand hay cutter head operation for not causing nervous animal, fear and struggle is badly in need of in this experiment, with
Reduce multifactor interference bring experimental error.
Summary of the invention
The characteristic got into the cave is liked for existing hand hay cutter head instrument disadvantage and experimental mouse, the present invention provides a kind of for acute cerebral hypoxia
The hand hay cutter head device of experiment, to solve animal hand hay cutter head anxiety struggle and laboratory technician's risk problem of biting.The device includes with lower part
Part:
(1) cuboid of one groove of band 1: cuboid is 4~1000 centimetres long, 10~15 centimetres wide, 8~15 centimetres high；It is long
The length of cube upper groove is 10~15 centimetres, and width is 3~4 centimetres, and depth is 2~4 centimetres；
(2) 1 section of hollow pipe: 3 ~ 10 centimetres of pipe diameter, 5~10 centimetres of length；
(3) 1, chopper: chopper band pedestal, fixed edge, movable edge have blade, and fixed edge height is 6 ~ 12 centimetres, upper lower edge knife
Sword is unfolded into pass, and pass diameter is 4 ~ 10 centimetres；
The component (1), (2), (3) assembling on-link mode (OLM) are as follows: hollow pipe is horizontally placed on cuboid groove one end, and tight with groove
Closely connected conjunction, hollow pipe broken ends of fractured bone edge and groove broken ends of fractured bone coincident, and fitted closely with chopper fixed edge notch.
Preferably, in component (1), a length of 15 centimetres of the cuboid with groove, width be 9 centimetres, a height of 10 centimetres,
The width of groove is 4 centimetres, and depth is 2 centimetres, and length is 15 centimetres.
Preferably, in component (2), the hollow pipe pipe diameter is 4 centimetres, and length is 8 centimetres, hollow pipe total length
It is 7 centimetres short compared with cuboid groove length.
Preferably, in component (3), the chopper band pedestal, fixed edge, movable edge band blade, fixed edge height is 8 lis
Rice, upper lower edge blade opening can form pass, and the diameter in hole is 4 centimetres.
Preferably, in component (1), the shape of the groove is arc.
Preferably, in component (2), the shape of the hollow pipe is circle.
Preferably, in component (1) (2), the material of the cuboid and hollow pipe is wooden.
Preferably, in component (1) (2), coarse processing is done on the surface of the groove and hollow pipe.
Preferably, this instrument is mainly used for mouse.But those skilled in the art it is to be understood that the present invention for mouse but and unlimited
In mouse.
Beneficial effects of the present invention:
(1) present invention can make experimental animal moment by hand hay cutter head, solves that experimental animal hand hay cutter head is nervous, struggles and asks in its natural state
Topic effectively controls blood oxygen caused by animal struggles and is lost, reduces experimental error；
(2) present invention can solve laboratory technician and grab to be snapped by experimental mouse and catches cold nearly；
(3) operation of the present invention is simple, convenient；
(4) present invention production is simple and at low cost, is suitble to promote and apply.
Detailed description of the invention
Fig. 1 is component chopper of the present invention: 1. chopper activity edge；2. chopper blade；3. chopper fixed edge；4. chopper tool apron；
Fig. 2 is component of the present invention: the cuboid of 1 groove of band 1；
Fig. 3 is component of the present invention: 1 section of hollow pipe；
Fig. 4 is component assembly and connection figure of the present invention.
Specific embodiment
The present invention is specifically described below by embodiment, it is necessary to which indicated herein is that following embodiment is only used
It is further detailed in the present invention, should not be understood as limiting the scope of the invention, person skilled in art
The some nonessential modifications and adaptations made according to foregoing invention content, still fall within protection scope of the present invention.
Embodiment 1
Cutting up with a hay cutter head object is the Kunming kind healthy mice normally raised, and utilizes head experimental animal 0 struggle of present invention hand hay cutter, mouth breathing
Time is longer, and experimental data variance is small (21.58 ± 1.71 seconds)；Existing chopper cuts up with a hay cutter head method experimental mouse 10 struggles, anxiety and fears
Fear, disturbing factor is more, obtains experimental data variance greatly (19.32 ± 5.73 seconds), poor reliability.
Hand hay cutter head experiment is carried out by the following method:
(1) 18 ~ 19gSPF grades of the weight healthy Kunming mouses normally raised 20 are taken, be randomly divided into existing chopper hand hay cutter head group and
The present invention cuts up with a hay cutter 2 groups of head group, every group 10；
(2) it is normally raised in normal feeding environment 2 days；
(3) head is cut up with a hay cutter:
Existing chopper cuts up with a hay cutter head group operating method: experimental mouse being gripped, head is exposed, chopper mouth, chopper moment are sent into head
Under hand hay cutter, the record broken end mouth breathing time；
The present invention cuts up with a hay cutter head group operating method: gently pinching mousetail and lifts mouse and be placed in groove, mouse pierces along groove
Hollow pipe, head is automatically into chopper hole, under chopper moment cuts up with a hay cutter, the record broken end mouth breathing time.
In step (3) present invention hand hay cutter head method, it is described hand hay cutter head instrument include component be cuboid with groove, hollow pipe,
Chopper；
Present invention hand hay cutter head method in step (3), the connection type of the hand hay cutter head device element are as follows: hollow pipe is horizontally placed on cuboid groove
One end, and fitted closely with groove, hollow pipe broken ends of fractured bone edge and groove broken ends of fractured bone coincident, and close with chopper fixed edge notch
Fitting；
Present invention hand hay cutter head method in step (3), the length of the cuboid are 15 centimetres, and width is 9 centimetres, with a thickness of 10 centimetres,
Material is wooden；
Present invention hand hay cutter head method in step (3), the length of the groove are 15 centimetres, and width is 4 centimetres, and depth is 2 centimetres；
Present invention hand hay cutter head method in step (3), the length of the hollow pipe are 8 centimetres, and diameter is 4 centimetres, and material is hardboard；
Present invention hand hay cutter head method in step (3), the opening diameter of the chopper are 4 centimetres, and open height is 8 centimetres, and material is iron.
Embodiment 2
Cutting up with a hay cutter head object is the Kunming mouse normally raised, and is not struggled with the experimental mouse of present invention hand hay cutter head, administration group (23.78 ±
2.01 seconds) compared with the blank control group (20.95 ± 1.58 seconds) of present invention hand hay cutter head, experimental data variance is small, can be effective
Count the remarkable effect that drug increases Hypoxia toleration；It is struggled, is obtained real in various degree with existing chopper hand hay cutter head method experimental mouse
It is big (administration group 21.43 ± 6.01 seconds, blank control group 18.58 ± 5.12 seconds) to test data variance, it is poor conspicuousness cannot to be counted
It is different.
Hand hay cutter head experiment is carried out by the following method:
(1) 18 ~ 19gSPF grades of the weight healthy Kunming mouses normally raised 40 are taken, existing chopper hand hay cutter head blank is randomly divided into
Control group, existing chopper hand hay cutter head blank control group and the present invention cut up with a hay cutter head blank control group, 4 groups of head administration group, every group of present invention hand hay cutter
10；
(2) water supply 2 days are administered in normal feeding environment, 1 time a day；
(3) head is cut up with a hay cutter: existing chopper hand hay cutter head operating method and present invention hand hay cutter head operating method, it is same as Example 1
Hand hay cutter head hand hay cutter head device described in the existing chopper hand hay cutter head method of the present embodiment and present invention hand hay cutter head method is same as Example 1
Embodiment 3
Cutting up with a hay cutter head object is normal SPF grade healthy SD rats of raising, and it is big that existing chopper hand hay cutter head method hand grabs rat difficulty, experimental mouse struggle
More acutely；The present invention cuts up with a hay cutter head method rat without struggle, and moment cuts up with a hay cutter head in its natural state.
The present embodiment apparatus of the present invention are 20 centimetres in addition to rectangular body length, and recess width is 7 centimetres, and depth is 4 centimetres,
Length is 20 centimetres；Hollow pipe diameter is 7 centimetres, and length is 10 centimetres；Chopper aperture is 7 centimetres outer, remaining with implement 1 phase
Together.
Claims (13)
1. a kind of hand hay cutter head device for acute cerebral hypoxia experiment, which is characterized in that the hand hay cutter head device includes such as lower component:
(1) cuboid of one groove of band 1；
(2) one section of hollow pipe；
(3) one, chopper.
The assembly and connection of the component, it is characterised in that: hollow pipe is horizontally placed on cuboid groove one end, and closely pastes with groove
It closes, hollow pipe broken ends of fractured bone edge and groove broken ends of fractured bone coincident, and is fitted closely with chopper fixed edge notch.
2. hand hay cutter head device according to claim 1, which is characterized in that in component (1), the cuboid specification are as follows: long 4
It is~1000 centimetres, 10~15 centimetres wide, it is 8~15 centimetres high；The length of cuboid upper groove is 10~15 centimetres, and width is 3~4
Centimetre, depth is 2~4 centimetres.
3. hand hay cutter head device according to claim 1, which is characterized in that in component (2), the hollow pipe specification are as follows:
3 ~ 10 centimetres of diameter, 5~10 centimetres of length.
4. hand hay cutter head device according to claim 1, which is characterized in that in component (3), the specification of chopper are as follows: band pedestal, Gu
Determine edge, movable edge band blade, upper lower edge blade is unfolded into pass, and pass diameter is 4 ~ 10 centimetres, and fixed edge height is 6 ~
12 centimetres.
5. cutting up with a hay cutter head device according to claim 1, which is characterized in that the component of the hand hay cutter head device are as follows: one groove of band
Cuboid 1: cuboid is 4~1000 centimetres long, 10~15 centimetres wide, 8~15 centimetres high；The length of cuboid upper groove is 10
~15 centimetres, width is 3~4 centimetres, and depth is 2~4 centimetres；1 section of hollow pipe: 3 ~ 10 centimetres of diameter, 5~10 lis of length
Rice；1, chopper: chopper band pedestal, fixed edge, movable edge have blade, and upper lower edge blade is unfolded into pass, and pass diameter is
4 ~ 10 centimetres of height is formed, fixed edge height is 6 ~ 12 centimetres.
6. cutting up with a hay cutter head device according to claim 1, which is characterized in that in component (1), groove surface does coarse processing.
7. cutting up with a hay cutter head device according to claim 1, which is characterized in that in component (2), pipeline inner face does coarse processing.
8. cutting up with a hay cutter head device according to claim 1, which is characterized in that the material of component (1) includes wooden, metal, plastics.
9. cutting up with a hay cutter head device according to claim 1, which is characterized in that the material of component (2) includes wooden, metal, plastics, firmly
Cardboard.
10. cutting up with a hay cutter head device according to claim 1, which is characterized in that the material of component (3) is metal.
11. cutting up with a hay cutter head device according to claim 1, which is characterized in that the shape of component (1) described groove includes arc, straight
Angle flat shape.
12. cutting up with a hay cutter head device according to claim 1, which is characterized in that the shape of component (2) includes round, rectangular, polygon
Shape.
13. cutting up with a hay cutter head device according to claim 1, which is characterized in that the experimental animal include long-tail, happiness get into the cave it is dynamic
Object.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811164895.7A CN109363732A (en) | 2018-10-07 | 2018-10-07 | A kind of hand hay cutter head device for acute cerebral hypoxia pharmacological evaluation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811164895.7A CN109363732A (en) | 2018-10-07 | 2018-10-07 | A kind of hand hay cutter head device for acute cerebral hypoxia pharmacological evaluation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109363732A true CN109363732A (en) | 2019-02-22 |
Family
ID=65403652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811164895.7A Pending CN109363732A (en) | 2018-10-07 | 2018-10-07 | A kind of hand hay cutter head device for acute cerebral hypoxia pharmacological evaluation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109363732A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB967868A (en) * | 1961-12-20 | 1964-08-26 | Commissariat Energie Atomique | Apparatus for collecting the blood of animals |
| CN2500109Y (en) * | 2001-10-19 | 2002-07-17 | 西安交通大学 | Rat head cutter |
| CN201445566U (en) * | 2009-07-15 | 2010-05-05 | 姜姚军 | Rat decapitator |
| CN105796154A (en) * | 2016-05-18 | 2016-07-27 | 邹燕燕 | Orthopaedic cutting device |
| CN205572529U (en) * | 2016-03-22 | 2016-09-14 | 明良有限公司 | Multi -functional fruit vegetables segmentation machining workbench |
-
2018
- 2018-10-07 CN CN201811164895.7A patent/CN109363732A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB967868A (en) * | 1961-12-20 | 1964-08-26 | Commissariat Energie Atomique | Apparatus for collecting the blood of animals |
| CN2500109Y (en) * | 2001-10-19 | 2002-07-17 | 西安交通大学 | Rat head cutter |
| CN201445566U (en) * | 2009-07-15 | 2010-05-05 | 姜姚军 | Rat decapitator |
| CN205572529U (en) * | 2016-03-22 | 2016-09-14 | 明良有限公司 | Multi -functional fruit vegetables segmentation machining workbench |
| CN105796154A (en) * | 2016-05-18 | 2016-07-27 | 邹燕燕 | Orthopaedic cutting device |
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Application publication date: 20190222 |