CN109351301A - A kind of production system and its production method of nano biomedical material - Google Patents
A kind of production system and its production method of nano biomedical material Download PDFInfo
- Publication number
- CN109351301A CN109351301A CN201811365454.3A CN201811365454A CN109351301A CN 109351301 A CN109351301 A CN 109351301A CN 201811365454 A CN201811365454 A CN 201811365454A CN 109351301 A CN109351301 A CN 109351301A
- Authority
- CN
- China
- Prior art keywords
- magnetic
- particle
- reaction solution
- reactor
- nano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/087—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electric or magnetic energy
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0013—Controlling the temperature of the process
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
- B01J2204/005—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices the outlet side being of particular interest
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J2219/0803—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electric or magnetic energy
- B01J2219/085—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electric or magnetic energy creating magnetic fields
- B01J2219/0854—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electric or magnetic energy creating magnetic fields employing electromagnets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J2219/0873—Materials to be treated
- B01J2219/0879—Solid
Abstract
The present invention provides the production system and its production method of a kind of nano biomedical material, which includes: reactor, the first membrane separator, the second membrane separator；The feed inlet of first membrane separator is communicated with the discharge port of reactor, and the discharge port of the first membrane separator is communicated with the feed inlet of reactor；The feed inlet of second membrane separator is communicated with the discharge port of reactor, and the discharge port of the second membrane separator is communicated with the feed inlet of reactor.The present invention only needs a reactor and two membrane separators, nano biomedical material can be prepared, entire production system is simple, reduce the equipment being related in nano biomedical material production process, and then reduce the contaminated possibility of medicine, to be conducive to improve the degree of purity of made nano biomedical material, and the reduction of number of devices, the production cost of nano biomedical material production is advantageously reduced.
Description
Technical field
The present invention relates to nano biomedical material technical field, in particular to a kind of production of nano biomedical material
System and its production method.
Background technique
In recent years, as the generation of nanotechnology, nano biomedical material are come into being, nano biomedical material draws
Rise unique biocompatibility, good degradation property, height targeting the advantages that ground as the important of bio-medical field
Study carefully object.But the industrialized production system in relation to nano biomedical material and its production method are deficient at present, cause nanometer raw
The production cost of object medical material is higher, and existing production system because production method it is more complicated, the equipment being related to is more so that
Made nano biomedical material is easily contaminated, and then keeps its degree of purity lower, to influence its medical effect.
Summary of the invention
In view of this, the present invention is directed to propose a kind of production system of nano biomedical material, to solve existing nanometer
The problem of bio-medical material degree of purity is low and high production cost.
In order to achieve the above objectives, the technical scheme of the present invention is realized as follows:
A kind of production system of nano biomedical material, comprising:
Reactor carries out raw material reaction and is separated in initial magnetic-particle reaction solution with generating initial magnetic-particle reaction solution
Magnetic-particle and magnetic-particle is washed, to after washing magnetic-particle carry out process of refinement and remove do not meet grain
The magnetic-particle that diameter requires carries out macromolecule organic coating, right to the magnetic-particle for meeting molecular weight requirement after process of refinement
The magnetic-particle reaction solution for meeting molecular weight requirement after macromolecule organic coating is concentrated；
First membrane separator (2), the magnetic-particle for not meeting molecular weight requirement after removing process of refinement；
Second membrane separator (3), the magnetic-particle for not meeting molecular weight requirement after removing macromolecule organic coating；
The feed inlet of first membrane separator is communicated with the discharge port of the reactor, and first membrane separator goes out
Material mouth is communicated with the feed inlet of the reactor；The discharge port phase of the feed inlet of second membrane separator and the reactor
Logical, the discharge port of second membrane separator is communicated with the feed inlet of the reactor.
Optionally, the reactor includes reactor shell；Agitating device, spray equipment are provided in the reactor shell；
The top of the reactor shell is stretched out in one end of the agitating device, and the other end of the agitating device is arranged in the reaction shell
In vivo；The spray equipment is located between the other end of the agitating device and the top of the reactor shell；
Temperature-adjusting device and magnetic generation device are provided with outside the reactor shell；The temperature-adjusting device is located at institute
It states between magnetic generation device and the reactor shell.
Optionally, the temperature-adjusting device is located on the outer wall of the reactor shell；The magnetism generation device fitting
The temperature-adjusting device.
Optionally, the feed inlet of the reactor is located at the top of the reactor shell；The discharge port position of the reactor
In the bottom end of the reactor shell.
Optionally, the bottom end of the reactor shell is additionally provided with drain.
Optionally, the spray equipment includes multiple spray heads；Multiple spray heads are symmetricly set in the reactor shell.
Compared with the existing technology, the production system of nano biomedical material of the present invention has the advantage that
The production system of nano biomedical material of the invention carries out raw material by setting reactor in the reactor
Reaction, magnetic-particle separation, magnetic-particle washing, process of refinement, macromolecule organic coating and concentration etc., and reacting
Cheng Zhong removes the particle for not meeting molecular weight requirement by the first membrane separator, the second membrane separator that communicate with reactor, into
And satisfactory nano biomedical material is obtained, and entire production process, it is only necessary to a reactor and two membrane separators, it is raw
Production system is simple, reduces the equipment being related in nano biomedical material production process, and then it is contaminated to reduce medicine
Possibility advantageously reduces to be conducive to improve the degree of purity of made nano biomedical material, and the reduction of number of devices
The production cost of nano biomedical material production.
Another object of the present invention is to propose a kind of production method of nano biomedical material, to solve existing nanometer
The problem of bio-medical material degree of purity is low and high production cost.
In order to achieve the above objectives, the technical scheme of the present invention is realized as follows: a kind of life of nano biomedical material
Production method, comprising:
S1, the raw material for being used to prepare nano biomedical material is mixed, under normal pressure and constant temperature, is stirred, reaction,
Obtain initial magnetic-particle reaction solution；
Magnetic-particle in S2, the separation initial magnetic-particle reaction solution, and will reaction extraction raffinate discharge；
S3, the magnetic-particle of separation is washed, obtains target magnetic-particle；
S4, process of refinement is carried out to the target magnetic-particle, obtains initial magnetic nanoparticle reaction solution；
Particle size requirements are not met in S5, the removal initial magnetic nanoparticle reaction solution and do not meet molecular weight requirement
Initial magnetic nanoparticle obtains target magnetic nanoparticle reaction solution；
S6, macromolecule organic coating is carried out to the target magnetic nanoparticle reaction solution, obtains just eozoon cladding magnetic
Property nano particle reaction solution；
The first eozoon of molecular weight requirement is not met in S7, the removing just eozoon coated magnetic nano particle reaction solution
Coated magnetic nano particle obtains target organism coated magnetic nano particle reaction solution；
S8, the target organism coated magnetic nano particle reaction solution is concentrated, obtains nano biomedical material.
Optionally, process of refinement is carried out to the target magnetic-particle in the step S4, obtains initial magnetic Nano
Particle reaction liquid, comprising:
Process of refinement agent is added into the target magnetic-particle, under the constant temperature of normal pressure and room temperature~80 DEG C,
30~360min is stirred with the mixing speed of 500~2000rpm.
Optionally, macromolecule organic coating is carried out to the target magnetic nanoparticle reaction solution in the step S6, obtained
To first eozoon coated magnetic nano particle reaction solution, comprising:
High molecular material is added into the target magnetic nanoparticle reaction solution, in the constant temperature of normal pressure and room temperature~80 DEG C
Under the conditions of, 30~360min is stirred with the mixing speed of 200~1000rpm, it is anti-to obtain just eozoon coated magnetic nano particle
Answer liquid.
Optionally, it is removed in the step S5 and does not meet Particle size requirements and not in the initial magnetic nanoparticle reaction solution
The initial magnetic nanoparticle for meeting molecular weight requirement obtains target magnetic nanoparticle reaction solution, comprising:
The initial magnetic nanoparticle reaction solution is settled, removal does not meet the initial magnetic Nano of Particle size requirements
Grain, then the initial magnetic nanoparticle reaction solution for meeting Particle size requirements is subjected to biofiltration, removal does not meet molecular weight requirement
Initial magnetic nanoparticle, obtain target magnetic nanoparticle reaction solution.
Compared with the existing technology, the production method of nano biomedical material of the present invention has the advantage that
The production method of nano biomedical material of the invention is inhaled by the generation of magnetic-particle, the magnetic of magnetic-particle
Attached, process of refinement, macromolecule organic coating, concentration and three times removal of impurities etc. techniques so that made nano biomedical material have
There is higher degree of purity, and then is conducive to enhance its using effect, and reaction condition of the present invention is mild, is applicable not only to nanometer
The production of bio-medical material is also applied for the production of other medicine with similar or identical performance, applied widely.Separately
Outside, production method of the present invention is simple, advantageously reduces the production cost of nano biomedical material, and then is conducive to its industrialization
Production.
Detailed description of the invention
The attached drawing for constituting a part of the invention is used to provide further understanding of the present invention, schematic reality of the invention
It applies example and its explanation is used to explain the present invention, do not constitute improper limitations of the present invention.In the accompanying drawings:
Fig. 1 is the schematic diagram of the production system of nano biomedical material described in the embodiment of the present invention；
Fig. 2 is the front view of reactor in Fig. 1；
Fig. 3 is the top view of reactor in Fig. 1；
Fig. 4 is the production method flow chart of nano biomedical material described in the embodiment of the present invention.
Description of symbols:
1- reactor, the first membrane separator of 2-, the second membrane separator of 3-；
11- agitating device, 12- spray equipment, 13- temperature-adjusting device, 14- magnetism generation device, 15- drain, 16-
Reactor shell；
111- agitating shaft, 112- agitating paddle, 121- spray head.
Specific embodiment
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
The present invention will be described in detail below with reference to the accompanying drawings and embodiments.
Embodiment 1
In conjunction with shown in Fig. 1-3, a kind of production system of nano biomedical material, comprising:
Reactor 1 carries out raw material reaction to generate initial magnetic-particle reaction solution and separates initial magnetic-particle reaction solution
In magnetic-particle and magnetic-particle is washed, to after washing magnetic-particle carry out process of refinement and remove do not meet
The magnetic-particle of Particle size requirements, to meet after process of refinement molecular weight requirement magnetic-particle carry out macromolecule organic coating,
The magnetic-particle reaction solution for meeting molecular weight requirement after macromolecule organic coating is concentrated；
First membrane separator 2, not meeting after removing process of refinement and do not meet of molecular weight requirement at Particle size requirements
Grain；
Second membrane separator 3, the particle for not meeting molecular weight requirement after removing macromolecule organic coating；
The feed inlet of first membrane separator 2 is communicated with the discharge port of reactor 1, the discharge port of the first membrane separator 2 and anti-
The feed inlet of device 1 is answered to communicate；The feed inlet of second membrane separator 3 is communicated with the discharge port of reactor 1, the second membrane separator 3
Discharge port is communicated with the feed inlet of reactor 1.Wherein, the feed inlet of reactor 1 also can be used as the first membrane separator 2 and the second film
In separator 3 in the return port of material Returning reactor 1 and reactor 1 material distillation and concentration steam (vapor) outlet.
The production system of the nano biomedical material of the present embodiment is carried out in reactor 1 by setting reactor 1
Raw material reaction, magnetic-particle separation, magnetic-particle washing, process of refinement, macromolecule organic coating and concentration etc., and anti-
During answering, is removed by the first membrane separator 2, the second membrane separator 3 that are communicated with reactor 1 and do not meet molecular weight requirement
Particle, and then obtain satisfactory nano biomedical material, such as nano magnetic resonance imaging contrast medium, entire production process,
A reactor 1 and two membrane separators are only needed, production system is simple, reduces and relates in nano biomedical material production process
And the equipment arrived, and then the contaminated possibility of medicine is reduced, to be conducive to improve the pure of made nano biomedical material
Cleanliness, and the reduction of number of devices advantageously reduce the production cost of nano biomedical material production.
In the present embodiment, reactor 1 includes reactor shell 16, and it can also be other shapes that reactor shell 16, which can be cylindrical shape,
Shape, in order to save lateral occupied space, generally vertical setting；Agitating device 11, spray equipment 12 are provided in reactor shell 16；
The top of reactor shell 16 is stretched out in one end of agitating device 11, and the other end of agitating device 11 is arranged in reactor shell 16；Spray
Shower device 12 is located between the other end of agitating device 11 and the top of reactor shell 16, in order to on 16 inner wall of reactor shell
The magnetic-particle of absorption is rinsed, wherein agitating device 11 specifically may include agitating shaft 111 and stirring slurry 112, agitating shaft
The top of reactor shell 16 is stretched out in 111 one end, is rotated by the motor outside reactor shell 16, agitating paddle 112 and stirring
The other end of axis 111 connects, and in order to react the reaction solution of 16 bottom end of reactor shell sufficiently, and agitating paddle 112 leans on proximal response
The bottom end of shell；
Temperature-adjusting device 13 and magnetic generation device 14 are provided with outside reactor shell 16；Temperature-adjusting device 13 is located at magnetic
Between property generation device 14 and reactor shell 16, wherein temperature-adjusting device can lead to Cooling and Heat Source, and magnetic devices can be permanent magnetism or electricity
Magnetic coil.After each raw material enters reactor 1, the agitating device 11 in reactor shell 16 can be stirred it, make it sufficiently
Hybrid reaction generates the reaction solution with magnetic-particle, and the magnetic generation device 14 outside reactor shell 16 is to the magnetic in reaction solution
Property particle carry out magnetic absorption be attached to it on inner wall of reactor shell 16, the spray equipment 12 in reactor shell 16 is sprayable
Water or water phase related solvents carry out once washing removal of impurities to the magnetic-particle on 16 inner wall of reactor shell, remove in magnetic-particle
Solution, and in order to improve the efficiency of washing impurity-removing, the settable multiple spray heads 121 of spray equipment 12, and multiple spray heads 121 are symmetrical
It is arranged in reactor shell 16, and spray head 121, towards the inner wall of reactor shell 16, angle can be adjusted as needed, instead
It answers the temperature-adjusting device 13 outside shell 16 that the temperature in reactor 1 is adjusted, and then adjusts in reactor shell 16 and respectively react rank
The reaction rate of section, in the present embodiment, each production equipment characteristics of compact layout advantageously reduces the space hold of entire production system
Rate.
Moreover, in the present embodiment, the feed inlet of reactor 1 is located at the top of reactor shell 16；The discharge port of reactor 1
Positioned at the bottom end of reactor shell 16.Feed inlet is arranged on the top of reactor shell 16 in the present embodiment, and at the bottom of reactor shell 16
End setting discharge port, because of the gravity of itself, can be carried out when each raw material successively puts into reactor 1 from 1 feed inlet of reactor
It is preliminary from mixing, when after reaction, each raw material can also rely on the gravity of itself, from the discharge port of reactor 1 from being discharged, be not required to
Separately setting power device discharges it reactor 1, avoids the increase of energy consumption in production process, and is conducive to simplify production system, drop
Low production cost.
In addition, in the present embodiment, because the reactor shell 16 of reactor 1 is generally using the material with certain heating conduction
It is made, therefore, in order to improve the adjusting high efficiency of each stage of reaction reaction rate, temperature-adjusting device 13 is arranged in reaction shell
On the outer wall of body 16, and in order to effectively be adsorbed on magnetic-particle on the inner wall of reactor shell 16, magnetic generation device 14 is pasted
Temperature-adjusting device 13 is closed, avoids it between temperature-adjusting device 13 because of the presence in gap, and influences magnetic generation device
14 magnetic absorption effect.And because during the reaction, useless reaction solution need to exclude reactor 1, in order to avoid reactor 1
Discharge outlet impurity is mixed into, and then influences the degree of purity of made nano biomedical material, another in the bottom end of reactor shell 16
Peripheral hardware sets drain 15, useless reaction solution is discharged.
Embodiment 2
Using the technique of the production system production nano biomedical material of above-mentioned nano biomedical material, comprising:
S1, the raw material for being used to prepare nano biomedical material is put into reactor 1, reaction from the feed inlet of reactor 1
Device 1 stirs 30~360min under the constant temperature of normal pressure and room temperature~80 DEG C, with the mixing speed of 500~2000rpm, it obtains
To initial magnetic-particle reaction solution；
S2, the inner wall that the magnetic-particle in magnetic-particle reaction solution initial in reactor 1 is adsorbed on to reactor 1, and will
It reacts extraction raffinate and reactor 1 is discharged by the discharge port of reactor 1, wherein the magnetic field of reactor 1 is strong in magnetic-particle adsorption process
Degree is 2000 Gausses~10000 Gausses, by the setting of the magnetic field strength of reactor 1 in the range can while cost is reduced,
Guarantee that magnetic-particle can be effectively adsorbed on the inner wall of reactor 1；
S3, the magnetic-particle for the inner wall for being adsorbed on reactor 1 is washed, obtains target magnetic-particle, pass through washing
It can remove the impurity such as reaction solution of magnetic-particle adsorption, wherein cleaning solution is water or water phase related solvents, washes clean
Test stone is that the discharge liquor of washing is neutrality, i.e., the pH value of discharge liquor is 7；
S4, process of refinement is carried out to the target magnetic-particle in reactor 1, obtains initial magnetic nanoparticle reaction
Liquid can reduce target magnetic-particle grain diameter by process of refinement；
S5, the initial magnetic nanoparticle reaction solution in reactor 1 is settled, removal does not meet the initial magnetic of Particle size requirements
Property nano particle, then the initial magnetic nanoparticle reaction solutions of Particle size requirements will be met from the discharge port of reactor 1 via first
The feed inlet of membrane separator 2 is sent into the first membrane separator 2, and removal does not meet the initial magnetic nanoparticle of molecular weight requirement, obtains
To target magnetic nanoparticle reaction solution, wherein the initial magnetic nanoparticle for not meeting Particle size requirements is partial size > 12nm
Grain, the initial magnetic nanoparticle for not meeting molecular weight requirement is particle of the molecular weight less than 3500, and obtained target magnetism is received
The grain diameter of target magnetic nanoparticle is 1nm~12nm in rice grain reaction solution；
S6, by target magnetic nanoparticle reaction solution in the first membrane separator 2 from the discharge port of the first membrane separator 2 via
The feed inlet of reactor 1 is sent into reactor 1, and carries out macromolecule organic coating, obtains just eozoon coated magnetic nano particle
Reaction solution can increase hydrophily, the stability of made nano biomedical material by macromolecule organic coating, reduce its poison
Property and the non-specific adsorption in people's vivo applications；
S7, by the first eozoon coated magnetic nano particle reaction solution in reactor 1 from the discharge port of reactor 1 via
The feed inlet of two membrane separators 3 is sent into the second membrane separator 3, and the first eozoon coated magnetic that removing does not meet molecular weight requirement is received
Rice grain obtains target organism coated magnetic nano particle reaction solution, wherein does not meet the first eozoon cladding of molecular weight requirement
Magnetic nanoparticle is the particle that molecular weight is greater than 10000；
S8, by the target organism coated magnetic nano particle reaction solution in the second membrane separator 3 from the second membrane separator 3
Discharge port is sent into reactor 1 via the feed inlet of reactor 1, and is concentrated, and obtains nano biomedical material, wherein dense
Using carrying out by the way of distillation, the temperature of distillation is 60~70 DEG C for contracting, and the pressure of distillation is normal pressure, and the nano biological after concentration
The concentration of medical material is 1~10mg/mL, and in the concentration range, made nano biomedical material is not easy to be repelled by human body,
To be conducive to improve its medical effect.
Each raw material completes magnetic-particle in reactor 1 in the production technology of the nano biomedical material of the present embodiment
Generation, magnetic absorption, once washing removal of impurities, process of refinement, macromolecule organic coating, concentration, and in 2 He of the first membrane separator
Second of the removal of impurities and third time that magnetic-particle is respectively completed in second membrane separator 3 clean, so that made nano biological is medical
Material degree of purity with higher, and then be conducive to enhance its using effect, and the present embodiment reaction condition is mild, not only fits
For the production of nano biomedical material, it is also applied for the production of other medicine with similar or identical performance, is applicable in model
It encloses wide.In addition, the present embodiment simple production process, advantageously reduces the production cost of nano biomedical material, and then advantageous
In its industrialized production.
In the present embodiment, process of refinement is carried out to the target magnetic-particle in reactor 1 in step S4, obtained initial
Magnetic nanoparticle reaction solution is realized especially by such as under type:
Process of refinement agent is put into reactor 1 from the feed inlet of reactor 1, reactor 1 is in normal pressure and room temperature~80 DEG C
Constant temperature under, 30~360min is stirred with the mixing speed of 500~2000rpm.
By target magnetic nanoparticle reaction solution in the first membrane separator 2 from the discharging of the first membrane separator 2 in step S6
Mouth is sent into reactor 1 via the feed inlet of reactor 1, and carries out macromolecule organic coating, obtains just eozoon coated magnetic and receives
Rice grain reaction solution, it is realized especially by such as under type:
By target magnetic nanoparticle reaction solution in the first membrane separator 2 from the discharge port of the first membrane separator 2 via anti-
It answers the feed inlet of device 1 to be sent into reactor 1, and high molecular material is put into reactor 1 from the feed inlet of reactor 1, reactor 1 exists
Under normal pressure and the constant temperature of room temperature~80 DEG C, 30~360min is stirred with the mixing speed of 200~1000rpm, is obtained initial
Biological coated magnetic nano particle reaction solution, wherein high molecular material is hydrophilic macromolecule auxiliary material, stabilizer.
In the present embodiment, process of refinement is carried out to target magnetic-particle in reactor 1, after reducing its size, used
The mode of natural subsidence makes bulky grain therein (partial size > 12nm target magnetic-particle) be gathered in the bottom of reactor 1, to reach
To the purpose of removal bulky grain, method is simple, is not required to separately set bulky grain eliminating equipment, can further decrease production cost.And
In the present embodiment, the reasonable setting of the mixing speed and mixing time of reactor 1 can guarantee anti-while reducing production cost
It should be able to sufficiently carry out, and then be conducive to improve the purity and yield of made nano biomedical material, in addition, in the present embodiment
In, reactor 1, the first membrane separator 2 and the second membrane separator 3 carry out the operation of each technique, energy consumption at a temperature of mild
It is low, and then be conducive to further decrease its production cost.
Embodiment 3
As shown in connection with fig. 4, a kind of production method of nano biomedical material, comprising:
S1, the raw material for being used to prepare nano biomedical material is mixed, under normal pressure and constant temperature, is stirred, reaction,
Obtain initial magnetic-particle reaction solution, wherein the mixing speed of stirring be 500~2000rpm, mixing time be 30~
360min；The temperature of constant temperature is room temperature~80 DEG C；
Magnetic-particle in S2, the initial magnetic-particle reaction solution of separation, and reaction extraction raffinate is discharged, wherein magnetic-particle
Separation is carried out by the way of magnetic absorption, and the magnetic field strength during magnetic absorption is 2000 Gausses~10000 Gausses, by magnetic
Field intensity setting can guarantee that magnetic-particle can be effectively anti-from initial magnetic-particle while cost is reduced in the range
It answers in liquid and isolates；
S3, isolated magnetic-particle is washed, obtains target magnetic-particle, can remove magnetic-particle table by washing
The impurity such as the reaction solution of face absorption, wherein cleaning solution is water or water phase related solvents, and the test stone of washes clean is washing
Discharge liquor is neutrality, i.e., the pH value of discharge liquor is 7；
S4, process of refinement is carried out to target magnetic-particle, obtains initial magnetic nanoparticle reaction solution, passes through fining
Processing, can reduce the grain diameter of target magnetic-particle；
Particle size requirements are not met in S5, the initial magnetic nanoparticle reaction solution of removal and do not meet the initial of molecular weight requirement
Magnetic nanoparticle obtains target magnetic nanoparticle reaction solution, wherein does not meet the initial magnetic nanoparticle of Particle size requirements
For partial size > 12nm particle, the initial magnetic nanoparticle for not meeting molecular weight requirement is particle of the molecular weight less than 3500, is obtained
To target magnetic nanoparticle reaction solution in target magnetic nanoparticle grain diameter be 1nm~12nm；
S6, macromolecule organic coating is carried out to target magnetic nanoparticle reaction solution, obtains just eozoon coated magnetic and receives
Rice grain reaction solution can increase hydrophily, the stability of made nano biomedical material by macromolecule organic coating, drop
Its low toxicity and the non-specific adsorption in people's vivo applications；
S7, the first eozoon cladding that molecular weight requirement is not met in just eozoon coated magnetic nano particle reaction solution is removed
Magnetic nanoparticle obtains target organism coated magnetic nano particle reaction solution, wherein do not meet the initial life of molecular weight requirement
Object coated magnetic nano particle is the particle that molecular weight is greater than 10000；
S8, target organism coated magnetic nano particle reaction solution is concentrated, obtains nano biomedical material,
In, using carrying out by the way of distillation, the temperature of distillation is 60~70 DEG C for concentration, and the pressure of distillation is normal pressure, and receiving after concentration
The concentration of rice bio-medical material is 1~10mg/mL, and in the concentration range, made nano biomedical material is not easy by people
Body repels, to be conducive to improve its medical effect.
The production method of the nano biomedical material of the present embodiment passes through the generation of magnetic-particle, the magnetism of magnetic-particle
Absorption, process of refinement, macromolecule organic coating, concentration and clean three times so that made nano biomedical material have compared with
High degree of purity, and then be conducive to enhance the resolution of its imaging, and the present embodiment reaction condition is mild, is applicable not only to receive
The production of rice bio-medical material is also applied for the production of other medicine with similar or identical performance, applied widely.Separately
Outside, the present embodiment production method is simple, advantageously reduces the production cost of nano biomedical material, and then is conducive to its industry
Metaplasia produces.
In the present embodiment, process of refinement is carried out to target magnetic-particle in step S4, obtains initial magnetic Nano
Grain reaction solution, is realized especially by such as under type:
Process of refinement agent is added into target magnetic-particle, under the constant temperature of normal pressure and room temperature~80 DEG C, with 500
The mixing speed of~2000rpm stirs 30~360min.
Macromolecule organic coating is carried out to target magnetic nanoparticle reaction solution in step S6, obtains just eozoon cladding magnetic
Property nano particle reaction solution, especially by such as under type realize:
High molecular material is added into target magnetic nanoparticle reaction solution, in the constant temperature of normal pressure and room temperature~80 DEG C
Under, 30~360min is stirred with the mixing speed of 200~1000rpm, obtains just eozoon coated magnetic nano particle reaction solution,
Wherein, high molecular material is hydrophilic macromolecule auxiliary material, stabilizer.
It is removed in step S5 and does not meet Particle size requirements in initial magnetic nanoparticle reaction solution and do not meet molecular weight requirement
Initial magnetic nanoparticle, obtain target magnetic nanoparticle reaction solution, especially by such as under type realize:
Initial magnetic nanoparticle reaction solution is settled, removal does not meet the initial magnetic nanoparticle of Particle size requirements, then
The initial magnetic nanoparticle reaction solution for meeting Particle size requirements is subjected to biofiltration, removal does not meet the initial of molecular weight requirement
Magnetic nanoparticle obtains target magnetic nanoparticle reaction solution.
In the present embodiment, process of refinement is carried out to target magnetic-particle, after reducing its size, using natural subsidence
Mode assembles bulky grain therein (partial size > 12nm target magnetic-particle), to achieve the purpose that remove bulky grain, method letter
It is single, it is not required to separately set bulky grain eliminating equipment, production cost can be further decreased.And in the present embodiment, it is stirred in each reaction process
The reasonable setting for mixing speed and mixing time can guarantee that reaction can be carried out sufficiently, Jin Eryou while reducing production cost
Conducive to the purity and yield for improving made nanometer biomaterial for medical purpose, in addition, in the present embodiment, each reaction is without higher anti-
Answer temperature that can carry out, reaction condition is mild, and low energy consumption, and then is conducive to further decrease its production cost.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of production system of nano biomedical material characterized by comprising
Reactor (1) carries out raw material reaction and is separated in initial magnetic-particle reaction solution with generating initial magnetic-particle reaction solution
Magnetic-particle and magnetic-particle is washed, to after washing magnetic-particle carry out process of refinement and remove do not meet grain
The magnetic-particle that diameter requires carries out macromolecule organic coating, right to the magnetic-particle for meeting molecular weight requirement after process of refinement
The magnetic-particle reaction solution for meeting molecular weight requirement after macromolecule organic coating is concentrated；
First membrane separator (2), the magnetic-particle for not meeting molecular weight requirement after removing process of refinement；
Second membrane separator (3), the magnetic-particle for not meeting molecular weight requirement after removing macromolecule organic coating；
The feed inlet of first membrane separator (2) is communicated with the discharge port of the reactor (1), first membrane separator
(2) discharge port is communicated with the feed inlet of the reactor (1)；The feed inlet of second membrane separator (3) is reacted with described
The discharge port of device (1) communicates, and the discharge port of second membrane separator (3) is communicated with the feed inlet of the reactor (1).
2. the production system of nano biomedical material according to claim 1, which is characterized in that
The reactor (1) includes reactor shell (16)；Agitating device (11), spray dress are provided in the reactor shell (16)
Set (12)；The top of the reactor shell (16) is stretched out in one end of the agitating device (11), the agitating device (11) it is another
One end setting is in the reactor shell (16)；The spray equipment (12) is located at the other end and the institute of the agitating device (11)
Between the top for stating reactor shell (16)；
Temperature-adjusting device (13) and magnetic generation device (14) are provided with outside the reactor shell (16)；The temperature adjusts dress
(13) are set to be located between the magnetic generation device (14) and the reactor shell (16).
3. the production system of nano biomedical material according to claim 2, which is characterized in that the temperature adjusts dress
(13) are set to be located on the outer wall of the reactor shell (16)；The magnetism generation device (14) is bonded the temperature-adjusting device
(13)。
4. the production system of nano biomedical material according to claim 2, which is characterized in that the reactor (1)
Feed inlet be located at the top of the reactor shell (16)；The discharge port of the reactor (1) is located at the reactor shell (16)
Bottom end.
5. the production system of nano biomedical material according to claim 2, which is characterized in that the reactor shell
(16) bottom end is additionally provided with drain (15).
6. the production system of nano biomedical material according to claim 2, which is characterized in that the spray equipment
It (12) include multiple spray heads (121)；Multiple spray heads (121) are symmetricly set in the reactor shell (16).
7. a kind of production method of nano biomedical material characterized by comprising
S1, the raw material for being used to prepare nano biomedical material is mixed, under normal pressure and constant temperature, is stirred, reaction obtains
Initial magnetic-particle reaction solution；
Magnetic-particle in S2, the separation initial magnetic-particle reaction solution, and will reaction extraction raffinate discharge；
S3, the magnetic-particle of separation is washed, obtains target magnetic-particle；
S4, process of refinement is carried out to the target magnetic-particle, obtains initial magnetic nanoparticle reaction solution；
Particle size requirements are not met in S5, the removal initial magnetic nanoparticle reaction solution and do not meet the initial of molecular weight requirement
Magnetic nanoparticle obtains target magnetic nanoparticle reaction solution；
S6, macromolecule organic coating is carried out to the target magnetic nanoparticle reaction solution, obtains just eozoon coated magnetic and receives
Rice grain reaction solution；
The first eozoon cladding of molecular weight requirement is not met in S7, the removing just eozoon coated magnetic nano particle reaction solution
Magnetic nanoparticle obtains target organism coated magnetic nano particle reaction solution；
S8, the target organism coated magnetic nano particle reaction solution is concentrated, obtains nano biomedical material.
8. the production method of nano biomedical material according to claim 7, which is characterized in that right in the step S4
The target magnetic-particle carries out process of refinement, obtains initial magnetic nanoparticle reaction solution, comprising:
Process of refinement agent is added into the target magnetic-particle, under the constant temperature of normal pressure and room temperature~80 DEG C, with 500
The mixing speed of~2000rpm stirs 30~360min.
9. the production method of nano biomedical material according to claim 7, which is characterized in that right in the step S6
The target magnetic nanoparticle reaction solution carries out macromolecule organic coating, obtains just eozoon coated magnetic nano particle reaction
Liquid, comprising:
High molecular material is added into the target magnetic nanoparticle reaction solution, in the constant temperature of normal pressure and room temperature~80 DEG C
Under, 30~360min is stirred with the mixing speed of 200~1000rpm, obtains just eozoon coated magnetic nano particle reaction solution.
10. the production method of nano biomedical material according to claim 7, which is characterized in that in the step S5
It removes not meeting Particle size requirements in the initial magnetic nanoparticle reaction solution and do not meet the initial magnetism of molecular weight requirement and receive
Rice grain obtains target magnetic nanoparticle reaction solution, comprising:
The initial magnetic nanoparticle reaction solution is settled, removal does not meet the initial magnetic nanoparticle of Particle size requirements, then
The initial magnetic nanoparticle reaction solution for meeting Particle size requirements is subjected to biofiltration, removal does not meet the initial of molecular weight requirement
Magnetic nanoparticle obtains target magnetic nanoparticle reaction solution.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811348879 | 2018-11-13 | ||
| CN2018113488793 | 2018-11-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109351301A true CN109351301A (en) | 2019-02-19 |
| CN109351301B CN109351301B (en) | 2020-12-11 |
Family
ID=65345492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811365454.3A Active CN109351301B (en) | 2018-11-13 | 2018-11-16 | Production system and production method of nano biomedical material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109351301B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113856600A (en) * | 2021-11-01 | 2021-12-31 | 铜仁学院 | System for nanometer biological product production |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03146119A (en) * | 1989-11-02 | 1991-06-21 | Tdk Corp | Liquid membrane and substance separation using the membrane |
| CN1355319A (en) * | 2001-12-07 | 2002-06-26 | 清华大学 | Process for separating nucleic acid from biological particles by solid-phase carrier |
| CN1954908A (en) * | 2005-10-25 | 2007-05-02 | 中国科学院过程工程研究所 | Optical catalyst capable of magnetic separated and its preparation method |
| CN102806017A (en) * | 2012-08-27 | 2012-12-05 | 天津工业大学 | High-gradient magnetic separator and method for controlling inorganic pollution on surface of high-pressure membrane |
-
2018
- 2018-11-16 CN CN201811365454.3A patent/CN109351301B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03146119A (en) * | 1989-11-02 | 1991-06-21 | Tdk Corp | Liquid membrane and substance separation using the membrane |
| CN1355319A (en) * | 2001-12-07 | 2002-06-26 | 清华大学 | Process for separating nucleic acid from biological particles by solid-phase carrier |
| CN1954908A (en) * | 2005-10-25 | 2007-05-02 | 中国科学院过程工程研究所 | Optical catalyst capable of magnetic separated and its preparation method |
| CN102806017A (en) * | 2012-08-27 | 2012-12-05 | 天津工业大学 | High-gradient magnetic separator and method for controlling inorganic pollution on surface of high-pressure membrane |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113856600A (en) * | 2021-11-01 | 2021-12-31 | 铜仁学院 | System for nanometer biological product production |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109351301B (en) | 2020-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109351301A (en) | A kind of production system and its production method of nano biomedical material | |
| CN108421047A (en) | A kind of composite Nano medicament carrier system for having tumour and causing targeting ability | |
| CN107552810A (en) | A kind of preparation method of Nano Silver isometric particle | |
| CN107847825A (en) | Multifunctional particle piece-rate system | |
| CN113388515A (en) | System for exosome production and preparation and exosome preparation method thereof | |
| CN208454748U (en) | Sewage treatment equipment in a kind of processing of rice paper | |
| CN108456262A (en) | A kind of preparation process of high purity heparin sodium | |
| CN106984286A (en) | A kind of preparation method of polyethyleneimine-modified crosslinked chitosan microsphere | |
| CN106390841A (en) | Nutrient solution raw material anti-pollution mixing equipment used for biological medicine | |
| CN209575965U (en) | A kind of filter device that enzyme preparation production blocking-proof result is good | |
| CN205586650U (en) | A separation and purification filter equipment for bio -pharmaceuticals | |
| CN108946800A (en) | A kind of titanium dioxide and its preparation method and application of crystal face exposure | |
| CN108277150A (en) | A kind of Zymolysis Equipment prepared by kudzu root tea | |
| CN109382051A (en) | A kind of production system and its production technology of nano biomedical material | |
| CN207685042U (en) | A kind of novel efficient sewage treatment device | |
| CN209260097U (en) | Blender and bioreactor | |
| CN213347508U (en) | Ultrasonic ozone atomization gynecological therapeutic apparatus capable of adjusting flow and recycling and decomposing ozone | |
| CN219816059U (en) | Excrement fungus mixing device without rotating parts | |
| JP5563322B2 (en) | Process device with microbubble generator | |
| CN110229716A (en) | A kind of linseed oil decoloration process | |
| CN108558143A (en) | Sewage treatment equipment in a kind of processing of rice paper | |
| CN208747740U (en) | A kind of integration MBR membrane bioreactor | |
| CN209162096U (en) | Cell culture system | |
| RU186728U1 (en) | LABORATORY DEVICE FOR WASHING POWDER CHEMICAL REACTIONS FROM EXTERNAL IMPURITIES | |
| CN214218419U (en) | Multistage filtering device for preventing and treating underground water pollution |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |