CN109331757B - Tubular microreactor, microfluidic mixing method and preparation method thereof - Google Patents
Tubular microreactor, microfluidic mixing method and preparation method thereof Download PDFInfo
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- CN109331757B CN109331757B CN201811363635.2A CN201811363635A CN109331757B CN 109331757 B CN109331757 B CN 109331757B CN 201811363635 A CN201811363635 A CN 201811363635A CN 109331757 B CN109331757 B CN 109331757B
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 112
- 239000012530 fluid Substances 0.000 claims abstract description 78
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004907 flux Effects 0.000 abstract description 9
- 230000002035 prolonged effect Effects 0.000 abstract description 6
- 238000004891 communication Methods 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 description 9
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- 238000010586 diagram Methods 0.000 description 7
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
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- 230000009471 action Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0013—Controlling the temperature of the process
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
Abstract
The invention relates to the field of microfluidics, in particular to a tubular microreactor, a microfluidic mixing method and a preparation method thereof, wherein the tubular microreactor comprises: the micro-reaction channel is fixed on the inner wall and/or the outer wall of the heat conducting pipe. According to the tubular microreactor, the plurality of microreaction channels are distributed on the wall of the heat conduction pipe, and the temperature adjustment of the heat conduction pipe is fully utilized, so that the same and uniform reaction temperature is obtained for each microreaction channel, and the overall reaction efficiency and the overall reaction flux are improved; and by stacking the two micro-channels, the occupation of the plane space is reduced, the three-dimensional space is reasonably utilized, and the micro-reaction channel is prolonged; and secondly, three-dimensional cross mixing of fluids is realized through communication among the laminated micro-channels, and a narrowed outlet is not required to be arranged at the end of each micro-reaction channel unit, so that the flow velocity of the fluids is ensured, and the fluid flux and the reaction efficiency are improved.
Description
Technical Field
The invention relates to the field of microfluidics, in particular to a tubular microreactor, a microfluidic mixing method and a preparation method thereof.
Background
In the prior art, as shown in fig. 1, a heat conducting medium 1-2 is arranged outside a micro-reactor conduit 1-1, a reaction fluid A and a reaction fluid B are simultaneously introduced into the micro-reactor conduit 1-1, diffusion mixing is completed in the process of travelling in the micro-reactor conduit, and the temperature is controlled by the heat conducting medium outside the micro-reactor conduit.
In fact, this mixed form, although having a high flux, does not give adequate mixing of the finally formed mixed liquid, and the mixing effect is poor; and the center of the micro-reactor conduit is far away from the outer tube wall, namely the temperature control medium, so that the temperature control in the reaction process is inaccurate, and side reactions are easy to occur.
Disclosure of Invention
The invention aims to provide a tubular microreactor, a microfluidic mixing method and a preparation method thereof.
In order to achieve the above technical problems, the present invention provides a tubular microreactor comprising: the micro-reaction channel is fixed on the inner wall and/or the outer wall of the heat conducting pipe.
Preferably, the micro-reaction channels are arranged in a straight line along the length direction of the heat conducting pipe or are spirally arranged on the inner wall and/or the outer wall of the heat conducting pipe along the length direction of the heat conducting pipe; the micro-reaction channel comprises a micro-reaction channel unit; the micro reaction channel unit includes: and the two micro-channels are arranged in a vertically stacked mode and are communicated with each other, so that fluids in the two micro-channels are mixed with each other.
Preferably, a set of convection holes is arranged between the two micro-channels, and the set of convection holes comprises two convection holes so as to enable the fluids in the two micro-channels to cross and mix reciprocally.
Preferably, the micro flow channel is L-shaped; and
in the two micro flow channels stacked up and down,
the inflection point of the micro flow channel at the upper part is communicated with the end part of the micro flow channel at the lower part through a pair of flow holes;
the inflection point of the micro flow channel at the lower part is communicated with the end part of the micro flow channel at the upper part through the other convection hole.
Preferably, the micro-flow channels are L-shaped, and a drainage end communicated with the other micro-flow channel is arranged at the circulation end of one micro-flow channel,
in the two micro flow channels stacked up and down,
the fluid of the micro-flow channel positioned at the lower part is suitable for flowing into the micro-flow channel positioned at the upper part through a pair of flow holes and a drainage end head; and
the fluid in the upper microchannel is adapted to flow through the drainage tip to the lower microchannel through the other convection orifice.
Preferably, the micro-reaction channel unit adopts a multi-layer arrangement and comprises a middle layer, an upper layer and a lower layer, wherein
Grooves distributed along the micro-channel track are respectively arranged on the contact surfaces of the upper layer, the lower layer and the middle layer;
a group of convection holes are formed in the middle layer; and
the upper layer and the lower layer form two micro-channels after the grooves of the upper layer and the lower layer are attached to the middle layer, and the two micro-channels are suitable for enabling two fluids to pass through a group of convection holes to realize cross mixing through the two micro-channels.
The tubular micro-reactor has the beneficial effects that the micro-reaction channels are distributed on the inner wall and/or the outer wall of the heat conduction pipe, and the temperature regulation of the heat conduction pipe is fully utilized, so that the micro-reaction channels obtain the same and uniform reaction temperature, and the overall reaction efficiency and the overall reaction flux are improved; and by stacking the two micro-channels, the occupation of the plane space is reduced, the three-dimensional space is reasonably utilized, and the micro-reaction channel is prolonged; and secondly, three-dimensional cross mixing of fluids is realized through communication among the laminated micro-channels, and a narrowed outlet is not required to be arranged at the end of each micro-reaction channel unit, so that the flow velocity of the fluids is ensured, and the fluid flux and the reaction efficiency are improved.
The invention also provides a microfluidic mixing method, namely
A plurality of micro-reaction channels are arranged on the inner wall and/or the outer wall of the heat conducting pipe in a surrounding way,
the fluid travels along the heat conducting pipe in the micro-reaction channel, and the temperature of the fluid is regulated through the heat conducting pipe.
Preferably, the microfluidic mixing method is adapted to achieve cross-mixing of fluids of each microreaction channel during travel using a tubular microreactor as described above.
The micro-fluid mixing method has the beneficial effects that firstly, through the arrangement of the heat conducting pipes, the temperature control of the liquid in the micro-channels is realized, so that the mixing effect is promoted, and a plurality of micro-reaction channels are distributed on the inner wall and/or the outer wall of the heat conducting pipes, and the temperature adjustment of the heat conducting pipes is fully utilized, so that the micro-reaction channels obtain the same and uniform reaction temperature, and the overall reaction efficiency and the reaction flux are improved; secondly, by stacking two micro-channels, the occupation of plane space is reduced, the three-dimensional space is reasonably utilized, and the micro-reaction channel is prolonged; and moreover, the three-dimensional cross mixing of the fluids is realized through the communication between the laminated micro-channels, and a narrowed outlet is not required to be arranged at the end of each micro-reaction channel unit, so that the high flow rate of the fluids is ensured, the mixing efficiency is ensured, and the yield is improved.
The invention also provides a preparation method of the tubular microreactor, wherein at least one microreaction channel is attached to the inner wall and/or the outer wall of the heat conducting tube.
Preferably, the micro-reaction channels are arranged in a straight line along the length direction of the heat conducting pipe or are spirally arranged on the inner wall and/or the outer wall of the heat conducting pipe along the length direction of the heat conducting pipe.
The preparation method of the tubular microreactor has the beneficial effects of rapidness and good preparation effect.
Drawings
The invention will be further described with reference to the drawings and examples.
Fig. 1 is a prior art related to the background art.
Fig. 2 is a schematic structural view of a micro-reaction channel vertically arranged on the outer wall of a heat conducting pipe.
FIG. 3 is a schematic structural view of the micro-reaction channels spirally distributed on the outer wall of the heat conducting pipe.
FIG. 4 is a schematic structural view of a micro reaction channel according to the present invention.
FIG. 5 is a schematic structural view of a micro reaction channel unit in the first embodiment of the present invention.
Fig. 6 is a cross-sectional view of fig. 5 at A-A.
Fig. 7 is a cross-sectional view of fig. 5 at C-C.
Fig. 8 is a schematic diagram of fluid flow in two microchannels according to a first embodiment of the invention.
FIG. 9 is a schematic diagram showing the structure of a second embodiment of a micro reaction channel according to the present invention.
FIG. 10 is a schematic structural view of a micro reaction channel unit in a second embodiment of the present invention.
Fig. 11 is a cross-sectional view of fig. 10 at A-A.
Fig. 12 is a cross-sectional view of fig. 10 at C-C.
FIG. 13 is a schematic flow diagram of a second embodiment of the present invention.
Fig. 14 is a graph showing the results of an example of fluid mixing according to the second embodiment of the present invention.
In the figure:
a microreactor conduit 1-1, an external heat conducting medium 1-2;
a heat conduction pipe C1;
a micro reaction channel 1;
a micro reaction channel unit 10;
a microchannel 100, an upper microchannel 100a, a lower microchannel 100b, an inflection point 101, and an end 102;
convection hole 200, drainage tip 300;
a first inlet 501, a second inlet 502;
a liquid inlet 6; and a liquid outlet 7.
Detailed Description
The invention will now be described in further detail with reference to the accompanying drawings. The drawings are simplified schematic representations which merely illustrate the basic structure of the invention and therefore show only the structures which are relevant to the invention.
Example 1
This embodiment provides a tubular microreactor comprising: the micro-reaction channel comprises a heat conduction pipe C1 and at least one micro-reaction channel 1 fixed on the inner wall and/or the outer wall of the heat conduction pipe.
Two distribution forms of the micro-reaction channels 1 are provided, and fig. 2 is a schematic structural diagram of the micro-reaction channels 1 vertically arranged on the outer wall of the heat conducting pipe C1; fig. 3 is a schematic structural view of the micro-reaction channels 1 spirally distributed on the outer wall of the heat conducting tube C1 (wherein fig. 3 is a schematic view, and thus the micro-reaction channels 1 are shown in a schematic position form).
As shown in fig. 2, the micro-reaction channels 1 are arranged linearly along the length direction of the heat conduction pipe C1, wherein the micro-reaction channels 1 referred to herein are arranged linearly along the length direction of the heat conduction pipe C1, meaning that the length direction of the micro-reaction channels 1 is arranged linearly parallel to the length direction of the heat conduction pipe C1 or a plurality of micro-reaction channels 1 are parallel.
One of the arrangements provided in fig. 3 is a spiral arrangement, meaning that it extends helically around the heat pipe C1. The advantage of the spiral arrangement is that the mixing length of the micro-reaction channels is prolonged, thus enhancing the mixing effect.
When the number of the micro-reaction channels 1 is a plurality of, the whole reaction flux of the tubular micro-reactor can be improved, the micro-reaction channels 1 are distributed on the outer wall of the heat conducting pipe C1, the temperature adjustment of the heat conducting pipe C1 is fully utilized, the micro-reaction channels 1 obtain the same and uniform reaction temperature, and the whole reaction efficiency is improved.
The micro reaction channel 1 which is positioned on the inner wall of the heat conducting pipe is wholly immersed in the heat conducting pipe C1 and is distributed in the same or similar mode with the outer pipe.
The heat conducting pipe C1 can be filled with liquid such as heat conducting oil or water for adjusting the reaction temperature, and can be heated or cooled.
As a preferred embodiment of the micro-reaction channel.
FIG. 4 is a schematic structural view of a micro reaction channel according to the present invention.
FIG. 5 is a schematic structural view of a micro reaction channel unit in the first embodiment of the present invention.
The micro reaction channel 1 includes a micro reaction channel unit 10; the micro reaction channel unit 10 includes: two microchannels 100 are arranged one above the other, and the two microchannels 100 communicate with each other, so that the fluids in the two microchannels 100 are mixed with each other.
The tubular microreactor of the invention realizes full mixing of the liquid in the microreaction channel 1 under the promotion of the temperature of the heat conduction pipe C1, has good mixing effect and large mixed reaction flux, combines the advantages of the traditional tubular reactor and the microreactor, and overcomes the defects of the traditional tubular reactor and the microreactor.
By stacking the two micro-channels 100, the occupation of the plane space is reduced, the three-dimensional space is reasonably utilized, and the micro-reaction channel 1 is prolonged; secondly, the three-dimensional cross mixing of the fluids is realized through the communication between the laminated micro flow channels 100, and a narrowed outlet is not required to be arranged at the end of each micro reaction channel unit 10, so that the flow velocity of the fluids is ensured, and the reaction efficiency is improved.
And wherein the micro flow channel 100 has two embodiments as follows:
as an alternative embodiment of the micro reaction channel unit 10, referring to fig. 4 and 5, a set of convection holes 200 is provided between two micro flow channels 100, and the set of convection holes 200 includes two convection holes 200 to cross-mix fluids in the two micro flow channels 100 back and forth. The micro flow channel 100 may be L-shaped (bounded by the dashed line portion of fig. 5); and two micro flow channels 100 stacked up and down, wherein an inflection point 101 of the micro flow channel 100 positioned at the upper part is communicated with an end 102 of the micro flow channel 100 positioned at the lower part through a pair of flow holes 200; the inflection point 101 of the lower micro flow channel 100 is communicated with the end 102 of the upper micro flow channel 100 through the other convection hole 200, so that the fluid in the two micro flow channels 100 is mixed in a reciprocating and cross mode.
As can be seen from fig. 4 and 5, the two micro flow channels 100 stacked up and down are U-shaped from the top view, and the two L-shaped micro flow channels are arranged approximately symmetrically.
Fig. 6 is a cross-sectional view of fig. 5 at A-A. The cross-sectional view is such that fluid flows from the lower fluidic channel 100b to the upper fluidic channel 100a.
Fig. 7 is a cross-sectional view of fig. 5 at C-C. The cross-sectional view is such that fluid flows from the upper fluidic channel 100 to the lower fluidic channel 100.
As shown in fig. 6 and 7, it can be clearly seen that the two fluids repeatedly cross each other in the upper and lower micro flow channels 100 through the convection holes, respectively.
In fig. 5, the specific locations of inflection point 101 and end 102 are shown for clarity, and thus the convection holes are not shown.
Fig. 8 is a schematic diagram of fluid flow directions in two micro flow channels according to the first embodiment of the present invention, wherein the flow directions of the fluids in the upper micro flow channel 100a are mainly reflected, and the flow directions of the two fluids are respectively indicated by two arrows, that is, after the two fluids are respectively injected into the micro flow channel 100, the two fluids corresponding to the upper micro flow channel 100a and the lower micro flow channel 100b can be respectively flowed into the lower micro flow channel 100 and the upper micro flow channel 100a at the inflection point 101 and the end 102 to achieve cross mixing, the fluid of the upper micro flow channel 100a is flowed into the lower micro flow channel 100b at the inflection point 101 in a direction perpendicular to the paper surface to achieve mixing, and the fluid of the lower micro flow channel 100b is flowed into the upper micro flow channel 100a in a direction perpendicular to the paper surface to achieve mixing, and the two fluids can be clearly seen to be mixed in the upper micro flow channel 100a by two arrows in fig. 5; after mixing the fluid is discharged again to the next micro-reaction channel unit 10 arranged in series, and the above-described process is repeated.
As an alternative embodiment of the micro reaction channel unit 10.
FIG. 9 is a schematic diagram showing the structure of a second embodiment of a micro reaction channel according to the present invention.
FIG. 10 is a schematic structural view of a micro reaction channel unit in a second embodiment of the present invention.
As shown in fig. 9 and 10, the micro flow channels 100 are L-shaped, and a drainage tip 300 communicating with one another micro flow channel 100 is provided at the circulation end of one micro flow channel 100.
Fig. 11 is a cross-sectional view of fig. 10 at A-A. The cross-sectional view is such that fluid flows from the lower fluidic channel 100b to the upper fluidic channel 100a.
Fig. 12 is a cross-sectional view of fig. 10 at C-C. The cross-sectional view is such that fluid flows from the upper fluidic channel 100a to the lower fluidic channel 100b.
As shown in fig. 11 and 12, of the two microchannels 100 stacked up and down, the fluid in the lower microchannel 100b is adapted to flow into the upper microchannel 100a through the pair of flow holes 200 via the drainage tip 300 (the drainage tip 300 of the upper microchannel 100 a); and the fluid in the upper microchannel 100a is adapted to flow through the drainage tip 300 (the drainage tip 300 of the lower microchannel 100 b) to the lower microchannel 100b through the other convection hole 200.
The drainage tip 300 is provided to increase the mixing between the fluid in the lower micro flow channel 100 and the fluid entering the upper micro flow channel 100, thereby greatly improving the mixing efficiency.
Referring to fig. 9, after two fluids are injected into the micro flow channel 100 from the first inlet 501 and the second inlet 502, respectively, the two fluids are mixed at the two drainage tips 300, respectively, and then the fully mixed fluids are discharged from the liquid outlet 7.
FIG. 13 is a simplified fluid flow diagram of a second embodiment of the present invention, which primarily reflects the flow distribution of fluid in the upper microchannel 100 a; wherein, the fluid flows upward, i.e. is vertical to the paper surface, at the upper drainage end 300, i.e. at the convection hole 200 corresponding to the left side in the figure, while the fluid flows downward, i.e. is vertical to the paper surface, at the lower drainage end 300, i.e. at the convection hole 200 corresponding to the right side in the figure; the flow directions of the two fluids are indicated by the two arrows, respectively, and it is clear that the two fluids are mixed in the upper micro flow channel 100a by the two arrows.
As an optional structure of the micro-reaction channel unit, the micro-reaction channel unit adopts a multi-layer arrangement and comprises an intermediate layer, an upper layer and a lower layer; wherein the upper layer corresponds to the upper micro flow channel 100 and the lower layer corresponds to the lower micro flow channel 100; grooves distributed along the locus of the micro-channel 100 are respectively formed on the contact surfaces of the upper layer, the lower layer and the middle layer; the middle layer is provided with a group of convection holes 200; and the upper layer and the lower layer form two micro-channels 100 after the grooves of the upper layer and the lower layer are attached to the middle layer, and the two micro-channels are suitable for realizing cross mixing of two fluids through the two micro-channels in a reciprocating manner through a group of convection holes 200.
Fig. 14 is a graph showing the results of an example of fluid mixing according to the second embodiment of the present invention.
The fluid mixing simulation results were performed at an input fluid flow rate of 0.6 m/s.
The micro flow channels 100 of the upper layer and the micro flow channels 100 of the lower layer are respectively injected with different fluids, fluid A and fluid B are respectively defined, and obvious fluid cross mixing phenomenon can be seen in the first micro reaction channel unit 10, wherein white line parts (shown by AB in the figure) of the two fluids indicate that the two fluids perform mixing reaction; in the micro-reaction channel unit located at the rear stage, the significantly white line portion increases, and at the end, the two fluids are significantly well mixed.
From the above results, it can be seen that the present micro-reaction channel 1 can achieve rapid and uniform mixing at a high flow rate, and has a higher mixing efficiency than the conventional micro-reaction channel.
Example 2
Referring to fig. 4 to 13, on the basis of embodiment 1, embodiment 2 provides a microfluidic mixing method in which a plurality of micro-reaction channels are disposed around the inner wall and/or the outer wall of a heat transfer tube, and the fluids of the micro-reaction channels 1 are cross-mixed with each other under the promotion of the heat transfer tube C1 during the traveling process.
In this embodiment, the micro-reaction channels are arranged on the outer wall of the heat conducting pipe.
The microfluidic mixing method is suitable for achieving cross-mixing of fluids of each micro-reaction channel 1 during travel using the tubular microreactor described above.
The specific structure and working principle of the micro flow channel 100 in this embodiment are described in detail in embodiment 1 above, and will not be described here again.
According to the microfluidic mixing method, firstly, the temperature adjustment of the liquid in the micro-channel 100 is realized through the arrangement of the heat conduction pipe C1, so that the mixing effect is promoted;
secondly, by stacking the two micro-channels 100, the occupation of the plane space is reduced, the three-dimensional space is reasonably utilized, and the micro-reaction channel is prolonged;
further, the three-dimensional cross mixing of the fluids is achieved by the communication between the stacked micro flow channels 100, and there is no need to provide a narrowed outlet at the end of each micro reaction channel unit 1, thereby ensuring a high flow rate of the fluids, and improving the yield while ensuring the mixing efficiency.
Example 3
On the basis of the embodiment 1, the embodiment 3 also provides a preparation method of the tubular microreactor, and at least one microreaction channel is attached to the inner wall and/or the outer wall of the heat conducting tube.
In this embodiment, the micro-reaction channels are arranged on the outer wall of the heat conducting pipe.
Each micro-reaction channel 1 is suitable for being respectively arranged in a straight line along the length direction of the heat conducting pipe C1 or spirally wound on the outer wall of the heat conducting pipe C1 along the length direction of the heat conducting pipe C1.
The preparation method of the micro-reaction chip is quick in preparation and good in preparation effect.
In summary, the tubular microreactor controls the reaction temperature of the liquid in the microreaction channel 1 under the action of the heat conduction tube C1 to accelerate the mixing speed, and arranges a plurality of microreaction channels 1 on the outer wall of the heat conduction tube, so that the temperature adjustment of the heat conduction tube C1 is fully utilized, the microreaction channels 1 obtain the same and uniform reaction temperature, and the overall reaction efficiency and reaction flux are improved; and utilize the double-deck microchannel 100 that sets up to realize the upper and lower cross mixing of fluid with convection hole 200, adopted three-dimensional mode to increase the length of micro-reaction channel, can realize longer microchannel 100 reaction channel overall arrangement on same micro-reaction chip, improved micro-reaction effect to need not all to be equipped with the export of narrowing in every micro-reaction channel unit 10 end department, and then guaranteed the high velocity of flow of fluid, and when guaranteeing mixing efficiency, improved output.
With the above-described preferred embodiments according to the present invention as an illustration, the above-described descriptions can be used by persons skilled in the relevant art to make various changes and modifications without departing from the scope of the technical idea of the present invention. The technical scope of the present invention is not limited to the description, but must be determined according to the scope of claims.
Claims (5)
1. A tubular microreactor comprising:
the micro-reaction channel is fixed on the inner wall and/or the outer wall of the heat conducting pipe;
the micro-reaction channels are arranged in a straight line along the length direction of the heat conducting pipe or are spirally arranged on the wall of the heat conducting pipe along the length direction of the heat conducting pipe; and
the micro-reaction channel comprises a plurality of micro-reaction channel units;
the micro reaction channel unit includes: the two micro-channels are arranged in a vertically stacked mode and are communicated with each other, so that fluids in the two micro-channels are mixed with each other;
two groups of convection holes are arranged between the two micro-channels, and each group of convection holes comprises two convection holes so as to enable fluids in the two micro-channels to be mixed in a reciprocating and cross mode;
the micro-flow channel is L-shaped; and
in the two micro flow channels stacked up and down,
the inflection point of the micro flow channel at the upper part is communicated with the end part of the micro flow channel at the lower part through a pair of flow holes;
the inflection point of the micro flow channel at the lower part is communicated with the end part of the micro flow channel at the upper part through the other convection hole;
a drainage end communicated with the other micro-channel is arranged at the circulation end of one micro-channel,
in the two micro flow channels stacked up and down,
the fluid of the micro-flow channel positioned at the lower part is suitable for flowing into the micro-flow channel positioned at the upper part through a pair of flow holes and a drainage end head; and
the fluid in the upper microchannel is adapted to flow through the drainage tip to the lower microchannel through the other convection orifice.
2. A tubular microreactor as claimed in claim 1, wherein,
the micro-reaction channel unit adopts a multi-layer arrangement and comprises a middle layer, an upper layer and a lower layer, wherein
Grooves distributed along the micro-channel track are respectively arranged on the contact surfaces of the upper layer, the lower layer and the middle layer;
the middle layer is provided with a convection hole; and
the upper layer and the lower layer form two micro-channels after the grooves of the upper layer and the lower layer are attached to the middle layer, and the two micro-channels are suitable for enabling two fluids to pass through the opposite flow holes to cross and mix.
3. A microfluidic mixing method using the tubular microreactor according to claim 1, characterized in that,
a plurality of micro-reaction channels are distributed on the inner wall and/or the outer wall of the heat conducting pipe,
the fluid moves along the heat conducting pipe in the micro-reaction channel, and the temperature of the fluid is regulated through the heat conducting pipe;
the fluids of each micro-reaction channel are cross-mixed with each other during travel.
4. A process for preparing a tubular microreactor as claimed in claim 1, wherein,
at least one micro-reaction channel is attached to the inner wall and/or the outer wall of the heat conducting pipe.
5. The method according to claim 4, wherein,
the micro-reaction channels are arranged in a straight line along the length direction of the heat conducting pipe or are spirally arranged on the inner wall and/or the outer wall of the heat conducting pipe along the length direction of the heat conducting pipe.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010094660A (en) * | 2008-09-18 | 2010-04-30 | Toray Eng Co Ltd | Micro-reactor |
| JP4904374B2 (en) * | 2009-03-30 | 2012-03-28 | 東レエンジニアリング株式会社 | Microreactor |
| CN105126687A (en) * | 2015-09-16 | 2015-12-09 | 杭州电子科技大学 | Separable passive micromixer |
| CN209205267U (en) * | 2018-11-16 | 2019-08-06 | 常州那央生物科技有限公司 | Tubular microreactors |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010094660A (en) * | 2008-09-18 | 2010-04-30 | Toray Eng Co Ltd | Micro-reactor |
| JP4904374B2 (en) * | 2009-03-30 | 2012-03-28 | 東レエンジニアリング株式会社 | Microreactor |
| CN105126687A (en) * | 2015-09-16 | 2015-12-09 | 杭州电子科技大学 | Separable passive micromixer |
| CN209205267U (en) * | 2018-11-16 | 2019-08-06 | 常州那央生物科技有限公司 | Tubular microreactors |
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