CN109331347A - A kind of optical fiber punctures needle tubing and its application - Google Patents
A kind of optical fiber punctures needle tubing and its application Download PDFInfo
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- CN109331347A CN109331347A CN201811371989.1A CN201811371989A CN109331347A CN 109331347 A CN109331347 A CN 109331347A CN 201811371989 A CN201811371989 A CN 201811371989A CN 109331347 A CN109331347 A CN 109331347A
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- optical fiber
- needle tubing
- metal
- coating
- conehead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N2005/0602—Apparatus for use inside the body for treatment of blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N2005/0612—Apparatus for use inside the body using probes penetrating tissue; interstitial probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
Abstract
The present invention relates to a kind of optical fiber to puncture needle tubing and its application comprising optical fiber, optical fiber include main part and head, and head includes straight type head and draws conehead, and drawing the front end of conehead is using the taper end for drawing cone technique to be formed；The periphery of main part is enclosed with main body tube, and straight type head is wrapped with metal-coating, the periphery of conehead is drawn to be enclosed with overcoat polymer；In overcoat polymer, the place corresponding to taper end is the pyramidal structure that diameter is sequentially reduced；Overcoat polymer is externally provided with down dentalation or kerf structure.The puncture needle tubing passes through the mutual synergistic effect of all parts, can be realized the purpose transmitted in long blood vessel faster；And can be realized higher light extraction efficiency and therapeutic effect, there is important application value and meaning in photodynamic tumor-treatment.And the puncture needle tubing can also be applied in other fields, such as eliminate blood vessel occlusion or carry out vascular puncture.
Description
Technical field
The present invention relates to a kind of the field of medical instrument technology, and in particular to a kind of optical fiber punctures needle tubing and its application.
Background technique
Photodynamic therapy (Photodynamic Therapy, PDT) is to carry out medical diagnosis on disease using photodynamic effect and control
A kind of new technology treated.Its exposure basis is photodynamic effect.This is a kind of light of adjoint biological effect for having oxygen molecule to participate in
Sensitized reaction.Its process is that the laser irradiation of specific wavelength excites the photosensitizer of tissue resorption, and excitation state is photosensitive
Agent generates highly active singlet oxygen, oxygen occurs for singlet oxygen and adjacent large biological molecule again energy transmission to the oxygen of surrounding
Change reaction, generates cytotoxic effect, and then lead to cell damage or even death.Compared to traditional remedies, photodynamic therapy has
Wound is small, targeting is good, without drug resistance and the advantages of toxic side effect.But since the main wavelength of photodynamic therapy concentrates on more than 600
The red spectral band of nanometer, this wave band is big in the loss of people's body absorption, can only generally transmit several millimeters to tens of milliseconds magnitude, for
Some deep tumors can not play the role of effective optical dynamic therapy.By optical fiber, endoscope and other interventional techniques, can incite somebody to action
Laser aiming is treated to internal deep, the wound and pain caused by operation such as avoids out chest, opens abdomen.It uses and contains at present
The puncture needle of optical fiber can introduce light into vivo, but due to needing to export light from optical fiber, needle point needs to have sufficiently large
Small hole increases the diameter of syringe needle so that light appears.To overcome penetration Resistance, optical fiber is wrapped up by hard metal material,
Needle tubing is thicker, needs to make its puncture using very big pressure in puncture process, be easy to cause biggish wound, destroy normal blood
Tubing causes bleeding.Therefore, in response to this series of problems, the application has studied a kind of optical fiber puncture needle tubing.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of optical fiber to puncture needle tubing and its application, solve in the prior art
Existing deficiency.
The purpose of the present invention is be achieved through the following technical solutions:
A kind of optical fiber puncture needle tubing comprising optical fiber, the optical fiber include main part and head, and the head includes straight type
Head and drawing conehead, the front end for drawing conehead or free end are using the taper tail for drawing the diameter of cone technique formation to be tapered
End；The periphery of the main part is enclosed with main body tube, and the straight type head is wrapped with metal-coating, the periphery packet for drawing conehead
It is wrapped with overcoat polymer, one end of the metal-coating is fixedly connected with main body tube, and the other end is fixedly connected with overcoat polymer；
In the overcoat polymer, the place corresponding to taper end is the pyramidal structure that diameter is sequentially reduced；The overcoat polymer
Dentalation or kerf structure are externally provided with down so that resistance is big when resistance small retrogressing when it advances, to effectively reduce puncture
The thrust needed.
Further, the metal-coating tight is in the periphery of the straight type head of optical fiber so that optical fiber is connected with metal-coating
It is integrated；The metal-coating is to carry out laser cutting on metal tube to form the helical structure of helical form joint-cutting to make it have one
Determine intensity while increasing certain flexibility.
Further, the main body tube is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is to be cut using laser
Cut the helical structure to form helical form joint-cutting.
Further, the main part packet for preventing the light in optical fiber from projecting from side is coated with outside the main part of the optical fiber
Layer；It is 1.45-1.55 that optical fiber, which draws the refractive index of conehead and overcoat polymer,.
Further, the cone angle beta for drawing conehead 2 is 7-25 °.
Further, the dentalation that falls outside the overcoat polymer is the circle big by the small rear end diameter of multiple point diameters
Platform shape structure is constituted, so that optical fiber punctures needle tubing and more easily walks forward and be not easy to retreat.
Further, the kerf structure that falls outside the overcoat polymer is to be cut by laser to form wedge in the outer surface of metal tube
The joint-cutting of shape, the inclined direction of joint-cutting is to tilt backwards, and the width of joint-cutting is by lateral surface one end to close to medial surface
One end successively reduces.
Further, it is fallen in dentalation at this, the nose thickness of truncated cone-shaped structure is 50-70 μm, truncated cone-shaped structure
Rear end with a thickness of 90-110 μm, and the thickness difference of front-end and back-end be 30-50 μm.
Further, the optical fiber puncture needle stays in external one end and is connected with the power device for being able to carry out front and back vibration
So that it can give one forward pressure of optical fiber puncture needle while vibration.
Further, the power device is acoustic vibration motor, and the front and back Oscillation Amplitude of the power device is 10um-
500um, vibration frequency 10Hz-1000Hz.
Further, without the refractive index of package covering or covering outside the straight type head of optical fiber at the joint-cutting of the metal-coating
Type head more straight than optical fiber is smaller so as to carry out out light at the joint-cutting that a part of light passes through spiral sleeve.
Further, the length on the head is 7-10mm, wherein the length of the overcoat polymer is 2.5-4mm；Institute
The length for stating metal-coating is 4.5-6mm.
Further, in metal-coating, the width of joint-cutting is 0.1-0.2mm, constitutes the gold of metal-coating helical structure
The width for belonging to piece is 0.2-1mm.
Further, in the main body tube, with a thickness of 0.05-0.1mm, the width for constituting the joint-cutting of helical structure is
0.02-0.2mm, the width for constituting the flight of helical structure is 0.5-3mm.
Further, in the drawing conehead, the most advanced diameter of taper end is 10-50 μm.
Further, the length of the main body tube is 1-2m；The main body tube is biomedical metallic material, including but not
It is limited to one of stainless steel, synthetic fibers, carbon fiber, titanium alloy, Jin Heyin.
A kind of optical fiber punctures the application of needle tubing, the optical fiber puncture needle tubing in long blood vessel the puncture of walking, vascular wall etc.,
Application in irradiation of the blood vessel of light power oncology and human body depths, tissue or organ etc..
The present invention provides a kind of optical fiber to puncture needle tubing and its application, main to have the beneficial effect that the puncture needle tubing is logical
The mutual synergistic effect for crossing all parts, can be realized the purpose transmitted in long blood vessel faster, as can smoothly wearing
It is about to nearly 2 meters of length of vessel；And can be realized higher light extraction efficiency and therapeutic effect, have in photodynamic tumor-treatment
Important application value and meaning.And the puncture needle tubing can also be applied in other fields, such as eliminate blood vessel occlusion or into
Row vascular puncture etc..
The present invention is cleverly by forming the increasingly thinner drawing conehead of diameter using drawing cone technique for optical fiber head, so that light
Effective exposure rate greatly promote, be conducive to illumination and effective cooperation of photosensitizer, the waste of light or photosensitizer reduced, to increase
Add therapeutic effect, reduces cost.Importantly, passing through the specification of control drawing conehead, refractive index, drawing conehead or taper end
The refractive index of angle and overcoat polymer, realize draw on conehead mainly go out light can emphasis to expose to its front certain
In the range of angle, then illumination efficiency and therapeutic effect can be dramatically increased, so that light, photosensitizer waste rate are less, efficient
It is higher.
Straight type head carries out auxiliary irradiation to extension position, and the outer helical metal housing wrapped up is not only to puncture injector head
The flexibility and intensity in portion play a significant role, it is often more important that, length, spiral joint-cutting, flight or sheet metal width
It, i.e., can also while drawing conehead to go out light Deng all to having extremely important adjuvant treatment effect in terms of photodynamic tumor-treatment
It carries out going out light on a small quantity simultaneously from metal-coating joint-cutting, then assists the effective treatment for drawing conehead to realize to positions such as entire tumours.
It draws conehead thinner, increases its flexibility, brittleness reduces, it is not easy to situations such as this is disconnected occur.On overcoat polymer
Fall dentalation or resistance is big when resistance small retrogressing when kerf structure to advance, needed to effectively reduce to puncture
Thrust makes to puncture needle tubing in the blood vessel forward more smooth, reduces operating difficulty and operating time.Importantly, polymerization
Beyond the region of objective existence set can also protect optical fiber, make that conehead is drawn not allow frangibility, even if phenomena such as drawing conehead to fracture, also has outside polymer
The protection of set will not be lost in body to damage blood vessel etc..
Then the present invention cooperates vibrating motor by designing pawl shape structure or kerf structure outside overcoat polymer,
Effective transmission that is convenient, being not easy retrogressing of advancing is realized, is conducive to smoothly walk in the blood vessel.
The setting of vibrating motor can make to puncture the regular generation miniature deformation of needle tubing, and the screw pitch of spiral part is shunk,
Help to move ahead in the blood vessel, and overcoat polymer can prevent its retrogressing, therefore considerably increase laser propagation effect.
Generally speaking, clinical good application effect, it is practical, there is biggish application value.
Detailed description of the invention
Fig. 1 is the overall structure diagram that optical fiber described in the embodiment of the present invention punctures needle tubing；
Fig. 2 is the perspective structure schematic diagram that optical fiber described in the embodiment of the present invention punctures needle tubing；
Fig. 3 is the schematic diagram of the section structure of head end described in the embodiment of the present invention；
Fig. 4 is the perspective structure schematic diagram of head end described in the embodiment of the present invention；
Fig. 5 is the thickness structure schematic diagram of overcoat polymer described in the embodiment of the present invention；
Fig. 6 is the structural schematic diagram of metal-coating described in the embodiment of the present invention；
Fig. 7 is that the structure of the optical fiber puncture needle tubing traveling process described in the embodiment of the present invention under vibrating motor driving is shown
It is intended to；
Fig. 8 is another in the optical fiber puncture needle tubing traveling process under vibrating motor driving described in the embodiment of the present invention
A structural schematic diagram；
Fig. 9 is the section structural schematic diagram (seeing from inside to outside) of main body tube described in the embodiment of the present invention；
Figure 10 is the cross-sectional structure signal for the main body tube being wrapped in outside fiber body portion described in the embodiment of the present invention
Figure；
Figure 11 is the range schematic diagram that the light emission on drawing conehead or overcoat polymer described in the embodiment of the present invention 3 goes out；
Figure 12 is the emergent light spot schematic diagram that conehead is drawn described in the embodiment of the present invention；
Figure 13 is the structural schematic diagram of the outer surface of metal-coating described in the embodiment of the present invention 4；
Figure 14 is the structural schematic diagram of the outer surface of metal-coating described in the embodiment of the present invention 4.
In figure, straight type head -- 1, draw conehead -- 2, overcoat polymer -- 3, metal-coating -- 4, main part -- 8, main body tube --
9, taper end -- 21, pyramidal structure -- 31, dentalation -- 32, joint-cutting -- 33, it is responsible for housing -- 106, hydrophilic painting
Layer -- 107.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
It is a part of the embodiment of the present invention, instead of all the embodiments.The detailed description of the embodiment of the present invention presented below is simultaneously
It is not intended to be limiting the range of claimed invention, but is merely representative of selected embodiment of the invention.Based in the present invention
Embodiment, this field commonsense method personnel every other embodiment obtained without creative efforts,
It shall fall within the protection scope of the present invention.
Embodiment 1
A kind of optical fiber puncture needle tubing, shown in 1-4 comprising optical fiber, the optical fiber include main part 8 and head, the head
Portion includes straight type head 1 and draws conehead 2, the front end for drawing conehead 2 or free end be using draw the diameter of cone technique formation by
One end of the thin taper end 21 of gradual change, straight type head 1 is fixedly connected or is integrally formed with 8 integrally connected of main part, the other end with
The larger diameter end of conehead is drawn to be fixedly connected or be integrally formed.
The periphery of the main part 8 is enclosed with main body tube 9, and the straight type head 1 is wrapped with metal-coating 4, the metal
4 tight of housing is in the periphery of straight type head 1 so that the straight type head 1 and metal-coating 4 of optical fiber are connected as one；The drawing conehead
2 periphery is enclosed with overcoat polymer 3；One end of the metal-coating 4 is fixedly connected with overcoat polymer 3 or integrally connected,
One end of metal-coating is fixedly connected with main body tube or integrally connected；As shown in Figs. 1-2；The head of optical fiber and the metal outside head
Housing 4 and overcoat polymer 3 can be collectively referred to as head end.
The overcoat polymer 3 be it is transparent, in the overcoat polymer 3, taper end 21 corresponding to optical fiber it is outer
Side is equipped with the pyramidal structure 31 that diameter is sequentially reduced, then it is consistent with 21 structure of taper end of conehead 2 is drawn, as in Figure 2-4.
The material of the overcoat polymer 3 can be polyamide or polypropylene.Overcoat polymer 3 be externally provided with down dentalation or
Kerf structure, as shown in Figs 1-4, such structure have very little resistance when advancing, and when retreating, resistance is larger, so as to
It to apply in a manner of weak impact, is punctured in a manner of progressive, effectively reduces the pressure for puncturing and needing.
As further preferred embodiment, the dentalation 32 that falls outside the overcoat polymer 3 is by multiple front ends
The big truncated cone-shaped structure of the small rear end diameter of diameter is constituted, i.e., multiple truncated cone-shaped structures are end to end to be looped around the periphery for drawing conehead,
So that optical fiber punctures needle tubing and more easily walks forward and be not easy to retreat.
Specifically, as shown in figure 5, being fallen in dentalation 32 at this, the nose thickness c of truncated cone-shaped structure is 50-70 μm, circle
The thickness d of the rear end of platform shape structure is 90-110 μm, and the thickness difference of front-end and back-end is 30-50 μm.The control pair of the thickness
In effectively smoothly transmission is advanced important, thickness difference is too big then or to be will increase metal-coating outer diameter or needs to reduce
The internal diameter of metal-coating is then affected to integrated piercing needle tubing, and thickness difference is big, the diameter in truncated cone-shaped structure back side face
Increase larger, will increase whole advance resistance instead, and for minute blood vessel, also will increase the damage to blood vessel
Degree.If if thickness difference is too small, not having helps to advance, prevents that falls back most to use；Therefore, above-mentioned dentalation 32
Thickness and truncated cone-shaped structure rear and front end needle tubing is punctured for optical fiber the entirety such as thickness difference move ahead it is extremely important.
As further preferred embodiment, as in Figure 2-4, the metal-coating 4 is spiral helicine metal-coating,
The metal-coating 4 is to carry out laser cutting on metal tube to form the helical structure of helical form joint-cutting to make it have some strength
Increase certain flexibility simultaneously.
It is highly preferred that in metal-coating 4, as shown in fig. 6, the width a of joint-cutting is 0.1-0.5mm, as 0.1mm,
0.2mm, 0.3mm, 0.4mm, 0.5mm etc., the width b for constituting the sheet metal of 4 helical structure of metal-coating is 0.2-1mm, such as
0.2mm, 0.4mm, 0.6mm, 0.8mm, 1mm etc.；The width a of joint-cutting and the data of width b of sheet metal and matching for the two
Can conjunction relationship directly affects pass through blood vessel and the smoothness across blood vessel, but also affects and pierce into from a blood vessel
Enter the piercing intensity of another blood vessel.Width a and width b it is too wide it is too narrow can all affect its flexibility and intensity, intensity is too
It is strong then can not be and very big to the injury tolerance of blood vessel by the knee of blood vessel；It is flexible too strong, then it is longer can not to pass through length
Blood vessel, the length within 1 meter is easier to, but 1 meter or more of blood vessel is difficult across and user's bad control in vitro
And direction, when penetrating into another blood vessel from a blood vessel, due to the too low also bad puncture of intensity, intensity it is too strong and
Flexible too intensity cannot achieve up in the blood vessel or organ of depth into the human body, in liver neoplasm.Only suitable width a matches
Good effect can be realized by closing the suitable width side b.
As further preferred embodiment, the optical fiber, which punctures needle tubing and stays in external one end and be connected with, to be able to carry out
The power device of front and back vibration is so that it can puncture one forward pressure of needle tubing to optical fiber while vibration.
The power device is preferably acoustic vibration motor, i.e. vibrating motor, and the front and back Oscillation Amplitude of the power device is
10um-500um, vibration frequency 10Hz-1000Hz.
Such as: when puncturing, needle tubing will be punctured and connect acoustic vibration motor, vibration frequency 100Hz, Oscillation Amplitude is
50um.As Figure 7-8, when acoustic vibration motor vibrates forward, needle tubing overall structure deformation occurs conduction vibration is punctured, such as
Shown in Fig. 7, when vibrating forward, miniature deformation occurs for puncture needle, screw pitch in bending and metal-coating 4 including puncturing needle tubing
It shrinks, which promotes needle point to travel forward, resistance is overcome to puncture forward.When vibrating backward, as shown in figure 8, due to
Overcoat polymer 3 has dentalation, and frictional force is much larger than and travels forward, therefore when acoustic vibration motor vibrates backward, needle
Point tends to motionless and puncture needle tubing is pulled integrally to travel forward.Under the action of repeatedly vibrating while applying extra pressure, wear
Pricker pipe continues to puncture forward.Apply pressure needed for such puncture mode and be less than traditional puncture needle, therefore allows optical fiber puncture needle
It is thinner more soft, while can complete to puncture effect.
As further preferred embodiment, the length on the head is 7-10mm, wherein the overcoat polymer 3
Length L be 2.5-4mm, such as 3mm；The length l of the metal-coating 4 or straight type head 1 is 4.5-6mm, such as 5mm, such as Fig. 3 institute
Show.Overcoat polymer 3 draws the length of conehead 2 is too long to be easy to cause to damage to blood vessel, and is unfavorable at blood vessel slight curves
Walking, it is too short to cannot achieve puncture effect, and row can not be carried out in smooth, quick blood vessel under the cooperation of vibrating motor
It walks.Metal-coating 4 is too long or too short be also unfavorable for walking or cannot achieve in blood vessel good auxiliary conehead 2 is drawn to pierce through blood vessel
The operation such as wall, it is often more important that, certain light can be projected in the spiral joint-cutting of metal-coating 4, then adjuvant treatment can be achieved, therefore cut
Width, the length of metal-coating 4 etc. of seam and sheet metal play a significant role therapeutic effect.Therefore, it is only properly growing
In the case where degree, blood vessel can be passed through well, and completes the operations such as good transmission, piercing, had for puncture needle tubing and increased
Effect effect.
As further preferred embodiment, the length of the main body tube 9 is 1-2m, such as 1.8m, fiber body portion 8 with
The length of main body tube 9 is consistent, and main body tube tight is outer in the main part 8 of optical fiber so that the two is integrally formed, and facilitates transmission.
The diameter of the main part 8 of optical fiber and straight type head 1 can be 400 μm, can be silica fibre, in the drawings conehead, bore
The most advanced diameter of shape tail end is 10-50 μm, such as 20 μm, 30 μm, 40 μm, which will increase the flexibility of optical fiber instead,
Reduce its brittleness；The outer diameter of the metal-coating 4 and main body tube 9 can be 600 μm, and internal diameter can be 400 μm.
In the present embodiment, it in use, the head one end for puncturing needle tubing is pierced into blood vessel first, then passes in the blood vessel
Defeated, the external one end for puncturing needle tubing can connect vibrating motor, and puncture needle tubing is assisted to reach predetermined position by blood vessel, such as intracorporal
Tumour (such as liver neoplasm) is medium, and laser is then punctured needle tubing with optical fiber and is connect, and opening laser makes light pass to optical fiber
In main body tube, then drawing conehead is reached, finally by tumour of the overcoat polymer directive added with photosensitizer.
Embodiment 2
On the basis of embodiment 1, the main body tube 9 is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is
The helical structure of helical form joint-cutting is formed using laser cutting.
As shown in figure 9, based on the Fig. 9 pipe 9 section schematic diagram, and be the view seen from inside to outside from main body tube 9；It is described
In main body tube 9, the width a of joint-cutting is 0.02-0.2mm, such as 0.05,0.08mm, 0.1mm, 0.15mm, is constituted in main body tube 9
The width d of the flight of helical structure is 0.5-3mm, such as 1mm, with a thickness of 0.05-0.1mm, such as 0.08mm.The length of main body tube 9
Nearly 2 meters of degree, penetrating human body usually just has 1-1.8m, and human vas thickness is different, there are also certain curvature, so long
Distance, such special vascular environment, it is very high to its intensity and flexibility requirements, therefore the width of the width a of joint-cutting, flight
Can the data and matching relationship of d and its thickness directly affect pass through blood vessel and the smoothness across blood vessel, even
Have an effect on the intensity that head is pierced into tumor vessel wall.Too wide too narrow its flexibility and strong of all affecting of width a and width d
Degree, only suitable width a cooperate the suitable width side d that can realize good effect.
The main body tube 9 is biomedical metallic material, and including but not limited to stainless steel, synthetic fibers, carbon fiber, titanium close
One of gold, Jin Heyin, preferably stainless steel, see on the whole, which wrapped up simultaneously by a stainless steel wire in fact
It is helically wound around the wrapping wire layer of 8 periphery of main part of optical fiber, can also be two or more wrapping wire windings certainly.
As shown in figs. 9-10, the main body tube 9 is externally provided with supervisor's housing 106 to increase the leakproofness and reduction of main body tube 9
Resistance；The material for being responsible for housing 106 can be polyamide or polypropylene etc., and other many polymer are ok.Outside the supervisor
The outside of set 106 is coated with hydrophilic coating 107 to increase blood compatibility.The hydrophilic coating 107 is using chemically stable
Material is made, including but not limited to polytetrafluoroethylene (PTFE), silicon rubber, polyethylene, polyvinyl chloride, fluorocarbon polymer and polyurethane.It applies
Hydrophilic coating is covered, resistance in the blood vessel is reduced, the long blood vessel of interior environment complexity can be passed through.
Hydrophobic coating substitution can be used in hydrophilic coating 107 in the present embodiment.
Embodiment 3
On the basis of embodiment 2, optical fiber draws the refractive index of conehead 2 for 1.45-1.55, and preferably 1.5, overcoat polymer
3 refractive index be 1.45-1.55, such as 1.45,1.5,1.55, then draw conehead 2 in taper end 21 cone angle beta be 7-25 °,
As shown in figure 5, the cone angle of the pyramidal structure in overcoat polymer 3 is also substantially consistent with taper end 21, then can guarantee substantially
The light that goes out for drawing conehead is to emit light within the scope of 60-120 °, and angle is as shown in the α in Figure 11.Specifically, pass through optical analog
It is found that cone angle beta is 22 °, then the angle of divergence alpha of light is within 120 °, if cone angle beta is 7.6 °, the angle of divergence alpha of light is within 60 °.
Therefore, when drawing the cone angle beta of conehead 2 to be 7-25 °, draw light on conehead can effective directive destination locations, such as containing photosensitive
In the tumour of agent, then luminous energy can be efficiently used, light emission rate is greatly increased.
The refractive index of entire optical fiber can be 1.5, it is preferable, however, that being coated with covering, the refractive index of covering outside fiber body portion 8
It lower than optical fibre refractivity, such as can be 1.2,1.3, so that the light in the main part 8 of optical fiber will not be projected from main part, constrain
Light issue light can only from drawing conehead, and by 3 direct irradiation of overcoat polymer to the tumour containing photosensitizer.
It is preferred that not having outside the straight type head 1 of the optical fiber at spiral helicine metal-coating 4, i.e. optical fiber at the joint-cutting of metal-coating 4
The refractive index type head 1 more straight than optical fiber for wrapping up covering or covering is smaller, then at the joint-cutting that the light of a part can be passed through spiral sleeve
Light is carried out out, realizes the irradiation to other auxiliary positions, then effectively to be irradiated by drawing conehead to attack keypoint part directly, directly
Type head 1 carries out auxiliary irradiation to extension position, realizes effective irradiation to whole position to be illuminated, as irradiation contains photosensitizer
Tumor tissues, can effectively increase photosensitizer drug effect performance, finally increase therapeutic effect.
In the present embodiment, if a length of 650nm of input optical fibre light wave, when input power is 1W, conehead is drawn to go out from optical fiber
Penetrating optical power is 0.94W, and emergent power is very high, and the angle of divergence is about 60 degree, can effectively be irradiated for keypoint part
Or treatment；Light spot shape is as shown in figure 12.
Embodiment 4
On the basis of any one in embodiment 1-3, overcoat polymer 3 or its outer surface are equipped with multiple joint-cuttings
33 structure falls joint-cutting 33 in the outer surface of metal tube laser cutting wedge shape as illustrated in figs. 13-14, i.e. joint-cutting 33
Inclined direction is to tilt backwards, and as shown in figure 13, the width of joint-cutting 33 is by lateral surface one end to close to medial surface one end,
Thickness successively reduces.
Preferably, the overcoat polymer 3 in the present embodiment can be for by tail end to front end, i.e., its diameter successively subtracts from back to front
Small structure facilitates advance, as illustrated in figs. 13-14.
Resistance is big when resistance small retrogressing when kerf structure to advance, so that the thrust for puncturing and needing is effectively reduced,
Make to puncture needle tubing in the blood vessel forward more smooth, reduces operating difficulty and operating time.
Embodiment 5
A kind of optical fiber punctures the application of needle tubing, which punctures needle tubing and can smoothly walk in long blood vessel, and can be to blood
Tube wall or obturator are effectively punctured, moreover it is possible to the irradiation of light are carried out to blood vessel, tissue or organ of human body depths etc., therefore this is worn
Pricker pipe can effectively be applied in light power oncology, additionally it is possible to be applied and in dredging vascellum internal resistance plug thing in group
There are extravasated blood or clot etc. to be dredged or treated in knitting.
It, will if interventional therapy is liver neoplasm if the optical fiber, which punctures needle tubing, to be used in photodynamic tumor-treatment
Optical fiber punctures needle tubing and enters liver artery by femoral artery puncture, finally enters blood vessel in liver neoplasm, laser is opened, light
On the drawing conehead for reaching optical fiber most end by optical fiber, then projected by overcoat polymer, and light is radiated at and has injected light
The tumour knurl of sensitizing drug (such as PHOTOFRINR), make the intracorporal photosensitive drug of tumor occur photochemical reaction generate singlet oxygen after
And cause necrosis and the apoptosis of tumour knurl, to achieve the purpose that treat tumour.
Light extraction efficiency of the invention is high, and light-out effect is good, and therapeutic efficiency is high.
Embodiment 6
In order to further study the practical function that the optical fiber in the present invention punctures needle tubing, the applicant is from the blood vessel passed through
Multiple latitudes such as type and length, crossing time, the dynamics at tip, radiation response, therapeutic efficiency and piercing precision carry out
Research.
Method: enter for liver neoplasm sampling biopsy: by Seldinger arteriopuncture technology, in irradiation image
Under guidance, optical fiber is punctured into needle tubing and is pierced into femoral artery, under the booster action of vibrating motor, it is dynamic to enter liver via femoral artery
Arteries and veins, then enter liver vessel from liver artery, eventually enter into inside tumor blood vessel；The tumor tissues that joined photosensitizer are carried out
Irradiation, treatment.
The length of vessel passed through: 1.6 meters.
It is tested the puncture needle tubing in embodiment 2 and 3 as experimental group 1 and 2.
Comparative example 1: non-polymer housing, it is other consistent with embodiment 3.
Comparative example 2: without draw conehead structure, the head diameter of optical fiber and it is other place, it is other with embodiment 2 one
It causes.
Comparative example 3: without spiral helicine metal-coating 4, i.e. drawing conehead is directly ined succession main part 8, it is other with embodiment 2 one
It causes.
Comparative example 4: the main body tube in embodiment 2 is become into spring.
Comparative example 5: the metal-coating 4 in embodiment 2 is become into spring.
For being summarized as follows shown in table for the above test group.
In upper table, 1) it reaches before the tumor vascular time refers to tumor vessel, required for walking in the blood vessel
Time.2) light extraction efficiency of optical fiber refers to the head of the light actually exposed on tumour photosensitizer and optical fiber by normal illumination extremely
The percentage of light on photosensitizer.3) the effective quantity of illumination on the photosensitizer for exposing to tumour that the illumination efficiency of optical fiber refers to,
It is proportional with absorption efficiency of the photosensitizer to light；4) it when tip dynamics refers to being pierced into tumor vessel inner wall when being pierced into, punctures
Power possessed by needle section.
The result of above-mentioned experimental group and contrast groups is described as follows shown:
Experimental group 1: intravascular walking is easy, and light emission rate, the illumination efficiency of optical fiber, puncture effect and therapeutic effect etc. are equal
It is relatively good.
Experimental group 2: intravascular walking is easy, and light emission rate, the illumination efficiency of optical fiber, puncture effect and therapeutic effect etc. are equal
It is relatively good.
Comparative example 1: due to non-polymer housing, also without dentalation, therefore the time walked in the blood vessel can increase
Add, and due to drawing conehead exposed, with certain brittleness, therefore needs carefully, also to will affect thetravel times in the blood vessel when walking.
Due to drawing conehead exposed, in transmission process, intravascular environment, which has it, to be had a certain impact, and in the process of walking,
On the also refractive index for influencing light and light emission rate easy to attach substance, therefore cause it in the light extraction efficiency of the optical fiber of destination locations
It is lower.Since its light extraction efficiency is lower, therefore the illumination efficiency of its optical fiber is leveraged, that is, exposes to effective light on photosensitizer
It reduces.Its tip dynamics when piercing through is substantially reduced.
Comparative example 2: since without conehead is drawn, therefore the intensity of the pyramidal structure 31 of overcoat polymer is inadequate, influences in the blood vessel
Walking, and its tip dynamics is very weak, is difficult to realize the purpose for piercing through vascular wall etc..In addition, then going out it due to without conehead is drawn
The specific aim of light is not strong, so that some light can not be effectively irradiated on photosensitizer, and few there may be light requirement
More light is irradiated in place instead, and needs the local exposure instead of emphasis illumination less, therefore its irradiation blindness is larger, optical fiber
Illumination efficiency it is low, leverage its therapeutic efficiency.
Comparative example 3: the metal-coating 4 without helical structure, light is only from drawing conehead to project, then the universal face of its irradiation is small,
It is only capable of exposing to certain key regions, for other auxiliary places almost without illumination, then leverages its whole irradiation effect
Rate, to leverage its therapeutic efficiency.And certain influence is also had on tip dynamics and travel time etc..
Comparative example 4: the bad control of spring and direction, therefore leverage the total time walked.Since dynamics is bad
Control, therefore the puncture effect dynamics of certain point is substantially reduced.
Comparative example 5: if selection intensity and the consistent spring of the intensity of metal-coating, flexibility, elasticity etc. and this hair
Bright metal-coating is had any different, and the bad control in its direction, and the dynamics for causing its whole tip to show is less than experimental group.
Embodiment 7
Tumor rat model is established, the rat for taking tumor size almost the same only adds photosensitive as experimental subjects, control group
Agent is treated, and experimental group adds photosensitizer and carries out illumination using method of the present invention.
Experimental group is that optical fiber described in embodiment 3 puncture needle tubing is irradiated laser.
Contrast groups 1-3 is the contrast groups 1-3 in embodiment 6, and laser irradiating method is consistent with experimental group.
Method: after treatment 10 days, dissecting rat, and do coronal incision by the surface seeding point of puncture of rat, by vertical and
Horizontal direction measures tumor size, gross tumor volume=Π/6 a2b (a is the minor axis of tumour, and b is the major diameter of tumour).Tumour growth
Inhibiting rate=[(control group tumor average volume-experimental group tumor average volume/control group tumor average volume) × 100%
To indicate.Then the inhibiting rate of resulting tumour growth is as shown in the table.
| Experimental group | Contrast groups 1 | Contrast groups 2 | Contrast groups 3 | |
| The inhibiting rate of tumour growth | 83.52% | 62.76% | 60.51% | 49.97% |
Therefore, in photodynamic tumor-treatment, the efficiency of light extraction efficiency and illumination has final therapeutic effect straight
Connect influence.The therapeutic effect of experimental group of the invention is apparently higher than the effect in contrast groups.
The above description is only a preferred embodiment of the present invention, is not intended to restrict the invention, for those skilled in the art
For, the invention can have various changes and changes.All any modifications made within the spirit and principles of the present invention are equal
Replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of optical fiber punctures needle tubing comprising optical fiber, it is characterised in that: the optical fiber includes main part and head, the head
Portion includes straight type head and draws conehead, and the drawing conehead is the taper end being tapered using the diameter for drawing cone technique to be formed；Institute
The periphery for stating main part is enclosed with main body tube, and the straight type head is wrapped with metal-coating, and the periphery for drawing conehead is enclosed with
One end of overcoat polymer, the metal-coating is fixedly connected with main body tube, and the other end is fixedly connected with overcoat polymer；
In the overcoat polymer, the place corresponding to taper end is that diameter is sequentially reduced and is wrapped in taper tail just
Hold the pyramidal structure of periphery；The overcoat polymer is externally provided with down dentalation or kerf structure so that resistance is small when it advances
Resistance is big when retrogressing, to effectively reduce the thrust for puncturing and needing.
2. optical fiber according to claim 1 punctures needle tubing, it is characterised in that: the metal-coating tight is straight in optical fiber
The periphery of type head is so that optical fiber and metal-coating are connected as one；The metal-coating is that laser cutting formation is carried out on metal tube
The helical structure of helical form joint-cutting is to make it have some strength while increase certain flexibility；
The main body tube is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is to form helical form using laser cutting to cut
The helical structure of seam.
3. optical fiber according to claim 2 punctures needle tubing, it is characterised in that: being coated with outside the main part of the optical fiber prevents
The main body wrap that light in optical fiber is projected from side；It is 1.45-1.55 that optical fiber, which draws the refractive index of conehead and overcoat polymer,
To facilitate light emission to go out；
The cone angle beta for drawing conehead is 7-25 °.
4. optical fiber according to claim 1 punctures needle tubing, it is characterised in that: the dentalation outside the overcoat polymer
To be made of the big truncated cone-shaped structure of the small rear end diameter of multiple point diameters so that optical fiber puncture needle tubing more easily forward walking and
It is not easy to retreat；
The kerf structure that falls outside the overcoat polymer is to be cut by laser to form the wedge-shaped joint-cutting that falls in the outer surface of metal tube,
The inclined direction of joint-cutting is to tilt backwards, and the width of joint-cutting is successively to be reduced by lateral surface one end to close to medial surface one end.
5. optical fiber according to claim 4 punctures needle tubing, it is characterised in that: it falls in dentalation at this, truncated cone-shaped structure
Nose thickness be 50-70 μm, the rear end of truncated cone-shaped structure with a thickness of 90-110 μm, and the thickness difference of front-end and back-end is
30-50μm。
6. optical fiber described in any one of -5 punctures needle tubing according to claim 1, it is characterised in that: the optical fiber puncture needle stays
One end in vitro is connected with the power device for being able to carry out front and back vibration so that it can be punctured while vibration to optical fiber
One forward pressure of needle.
7. optical fiber according to claim 6 punctures needle tubing, it is characterised in that: the power device is acoustic vibration motor,
The front and back Oscillation Amplitude of the power device is 10um-500um, vibration frequency 10Hz-1000Hz；
It is smaller without the refractive index type head more straight than optical fiber of package covering or covering outside the straight type head of optical fiber at the joint-cutting of metal-coating
So as to carry out out light at the joint-cutting that the light of a part passes through spiral sleeve；
In the drawing conehead, the most advanced diameter of taper end is 10-50 μm.
8. optical fiber according to claim 6 punctures needle tubing, it is characterised in that: the length on the head is 7-10mm, wherein
The length of the overcoat polymer is 2.5-4mm；The length of the metal-coating is 4.5-6mm；
In metal-coating, the width of joint-cutting is 0.1-0.2mm, and the width for constituting the sheet metal of metal-coating helical structure is
0.2-1mm；
In the main body tube, with a thickness of 0.05-0.1mm, the width for constituting the joint-cutting of helical structure is 0.02-0.2mm, is constituted
The width of the flight of helical structure is 0.5-3mm.
9. optical fiber according to claim 6 punctures needle tubing, it is characterised in that: the length of the main body tube is 1-2m；
The main body tube is biomedical metallic material, including but not limited to stainless steel, synthetic fibers, carbon fiber, titanium alloy, gold
One of with silver；
The main body tube is externally provided with supervisor's housing to increase the leakproofness of main body tube and reduce resistance；The outside of supervisor's housing
Coated with hydrophilic coating or water delivery coating.
10. the application that a kind of optical fiber punctures needle tubing, it is characterised in that: the optical fiber puncture needle tubing walk in long blood vessel, blood vessel
Application in the puncture of wall etc., irradiation of the blood vessel of light power oncology and human body depths, tissue or organ etc..
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| CN2018108431634 | 2018-07-27 | ||
| CN201810843163 | 2018-07-27 |
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