CN109321418A - A kind of sealwort health wine and preparation method thereof - Google Patents
A kind of sealwort health wine and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of sealwort health wine and preparation method thereof, the sealwort health wine uses ginseng, rhizoma polygonati, fructus lycii, rock sugar, Mentholum and white wine as raw material and carries out appropriate weight proportion, and the health liquor with benefiting qi and nourishing blood, nourishing liver and kidney, invigorating the spleen moistening lung and other effects is finally prepared.Product of the present invention can play the role of improving immunity, improve blood circulation, reduce cholesterol and relieve fatigue.Sealwort health wine of the present invention provides a kind of new health care's prescription for meeting theory of traditional Chinese medical science, and significant ingredient is general flavone, and further provides reasonable preparation method, and stability is good, clear and transparent, no precipitating and suspended matter.Sealwort health wine mouthfeel of the present invention is good, and fragrance is coordinated, and has the double action drunk with nourishing and health preserving, is suitble to the various age groups that have certain requirements to alcohol content and healthcare function, drinks in extensive range.
Description
Technical field
The invention belongs to technical field of health care, and in particular to a kind of sealwort health wine and preparation method thereof.
Background technique
With the work of modern, the increase of studying and living pressure, daily life system is irregular in addition, dietary structure changes
Become the reduction with amount of exercise, so that people are in sub-health state.Hypoimmunity, qi and blood be unsmooth, high cholesterol, spirit are tired
The symptoms such as idle and body fatiguability generally occur in modern.If it is big to expend people using herbal treatment somagenic need
Measure time and efforts, so need it is a kind of it is daily drinking convenient for modern, mouthfeel is pleasant and can adjust the drink of function of human body.
White wine is as drink indispensable in people's daily life, and demand also with consumer to drinking is towards low
The direction of degree, health care and functionalization is developed.In order to cater to the demand of the majority of consumers, being added in white wine has health care's function
The active ingredient of Chinese herbs of effect assigns the new connotation of white wine health care, can satisfy consumer to the new demand drunk.
Summary of the invention
In order to solve the above problems existing in the present technology, the present invention provides a kind of pairs for having both and drinking with nourishing and health preserving
Recast is used, mouthfeel is pleasant and has the rhizoma polygonati improve immunity, improve blood circulation, reduce cholesterol and relieve fatigue and other effects
Health preserving wine and preparation method thereof.Sealwort health wine described in long-term drinking can effectively adjust human body mechanism, play good health
Health-care effect.
The technical scheme adopted by the invention is as follows:
A kind of sealwort health wine, raw material components include:
Rhizoma polygonati, 48-72 parts by weight；
Ginseng, 9-15 parts by weight；
Fructus lycii, 19-29 parts by weight；
Rock sugar, 250-350 parts by weight；
Mentholum, 0.02-0.06 parts by weight；
White wine, 4580-5420 parts by weight.
The raw material components of the further preferred sealwort health wine include:
Rhizoma polygonati, 60 parts by weight；
Ginseng, 12 parts by weight；
Fructus lycii, 24 parts by weight；
Rock sugar, 300 parts by weight；
Mentholum, 0.04 parts by weight；
White wine, 4650 parts by weight.
A method of the sealwort health wine is prepared, is included the following steps:
(1) by the closed extraction of white wine of above-mentioned parts by weight rhizoma polygonati, ginseng and fructus lycii, filtering obtains leaching liquor and filter residue；
(2) filter residue is squeezed, press juice merges with the leaching liquor, and filtering obtains former wine；
(3) pure water is added into rock sugar, boils as syrup, gained syrup is added in the former wine, is stirred evenly,
Obtain sugaring former wine；
(4) Mentholum is dissolved with white wine, is added in the sugaring former wine, stirs evenly, obtains Mentholum former wine；
(5) the Mentholum former wine Alcohol degree is adjusted with white wine and pure water, is adjusted rear wine；Then to the tune
Wine is stood, is filtered, encapsulating obtains the sealwort health wine after whole.
Further, in step (1), the white wine is the fen-flavor type white spirit that Alcohol degree is 43-48%vol；Raw material with
Quality of white spirit ratio is 1:(6-10)；Extraction time is 8-12 days.
Further, in step (2), filter operation is filtered using 100-150 mesh stainless steel filtering net.
Further, in step (3), the mass ratio of rock sugar and pure water is (2.5-3.3): 1；Tanning temperature is 80-110
℃。
Further, in step (3), mixing speed 25-60r/min, mixing time 10-20min.
Further, in step (4), the mass ratio of Mentholum and white wine is 1:(6-10)；Mixing speed is 25-60r/
Min, mixing time 20-30min.
Further, in step (5), Mentholum former wine Alcohol degree is adjusted to 32-38%vol, rhizoma polygonati dosage and tune
The mass ratio of wine is 1:(80-87 after whole)；Time of repose is 10-14h.
Further, it in step (5), is filtered using plate filter, filter sizes 0.1-1um.
It underdraws below to effect caused by raw material in the present invention.
Ginseng, sweet in flavor, slight bitter, slightly warm in nature；Returns spleen, lung channel.Effect: reinforce vital energy, reinforce the spleen to benefit the lung, promoting the production of body fluid to quench thirst,
Tranquilize the mind and promote the intelligence.Be intended to take off for the deficiency of vital energy, feeble and impalpable pulse, anorexia and loose stool, shortness of breath and fatigue, injury thirst, the deficiency of Yin are quenched one's thirst, the mind is improper,
Insomnia and dreamful sleep, blood deficiency chlorosis, impotence due to deficiency of the kidney.
Rhizoma polygonati, it is sweet in flavor, it is mild-natured；Returns spleen, lung, kidney channel.Effect: boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing；For taste
The deficiency of vital energy, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis,
Heat Diabetes.
Fructus lycii, it is sweet in flavor, it is mild-natured；Return liver and kidney channel.Effect: nourishing liver and kidney, benefiting shrewd head.For: consumption consumptive loss, waist
Knee joint soreness, dizziness and tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision.
The invention has the benefit that
The present invention relates to a kind of sealwort health wine and preparation method thereof, the sealwort health wine uses ginseng, rhizoma polygonati, Chinese holly
Qi, rock sugar, Mentholum and white wine are raw material and carry out appropriate weight proportion, are finally prepared to have and improve immunity, improve
Blood circulation reduces cholesterol and alleviates the health liquor of fatigue effect.Product of the present invention, which provides, a kind of new meets middle medical knowledge
Health care's prescription of opinion, significant ingredient are general flavone.The effect of flavones is various: being a kind of very strong antioxygen
Agent can effectively remove intracorporal oxygen radical, can prevent degeneration, the aging of cell, can also prevent the generation of cancer；It can change
Kind blood circulation, reduces cholesterol；It can inhibit the exudation of inflammatory biological enzyme, promote wound healing and analgesic.It is of the present invention
Sealwort health wine general flavone content >=13.57mg/100mL.Invention further provides reasonable preparation method, stability
It is good, clear and transparent, no precipitating and suspended matter.Sealwort health wine mouthfeel of the present invention is good, and fragrance is coordinated, and has and drinks and nourish
The double action of health is suitble to the various age groups that have certain requirements to alcohol content and healthcare function, drinks in extensive range.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Embodiment 1
The present embodiment provides a kind of sealwort health wine, raw material components include:
Rhizoma polygonati, 48g；
Ginseng, 9g；
Fructus lycii, 19g；
Rock sugar, 250g；
Mentholum, 0.02g；
White wine, 4580g.
Further, the present embodiment provides the preparation method of the sealwort health wine, include the following steps:
(1) the closed extraction of fen-flavor type white spirit for being 43%vol with Alcohol degree by above-mentioned parts by weight rhizoma polygonati, ginseng and fructus lycii
8 days, raw material and quality of white spirit ratio were 1:6, and filtering obtains leaching liquor and filter residue；
(2) filter residue being squeezed, press juice merges with the leaching liquor, it is filtered using 100 mesh stainless steel filtering nets,
Obtain former wine；
(3) pure water of 2/5 mass is added into rock sugar, tanning is syrup at 80 DEG C, gained syrup is added to described
It is stirred in former wine, mixing speed 25r/min, mixing time 10min obtains sugaring former wine；
(4) white wine of 6 times of quality of Mentholum is dissolved, is added in the sugaring former wine and stirs, mixing speed is
25r/min, mixing time 20min obtain Mentholum former wine；
(5) the Mentholum former wine Alcohol degree is adjusted to 32%vol with white wine and pure water, be adjusted rear wine, Huang
The mass ratio of wine is 1:80 after smart dosage and adjustment, then stands 10h, is filtered using plate filter, filter sizes are
0.1um, encapsulating obtain the sealwort health wine.
Embodiment 2
The present embodiment provides a kind of sealwort health wine, raw material components include:
Rhizoma polygonati, 72g；
Ginseng, 15g；
Fructus lycii, 29g；
Rock sugar, 350g；
Mentholum, 0.06g；
White wine, 5420g.
Further, the present embodiment provides the preparation method of the sealwort health wine, include the following steps:
(1) the closed extraction of fen-flavor type white spirit for being 48%vol with Alcohol degree by above-mentioned parts by weight rhizoma polygonati, ginseng and fructus lycii
12 days, raw material and quality of white spirit ratio were 1:10, and filtering obtains leaching liquor and filter residue；
(2) filter residue being squeezed, press juice merges with the leaching liquor, it is filtered using 150 mesh stainless steel filtering nets,
Obtain former wine；
(3) pure water of 3/10 mass is added into rock sugar, tanning is syrup at 110 DEG C, and gained syrup is added to institute
It states in former wine and is stirred, mixing speed 60r/min, mixing time 20min obtain sugaring former wine；
(4) white wine of 10 times of quality of Mentholum is dissolved, is added in the sugaring former wine and stirs, mixing speed is
60r/min, mixing time 30min obtain Mentholum former wine；
(5) the Mentholum former wine Alcohol degree is adjusted to 32-38%vol with white wine and pure water, be adjusted rear wine,
The mass ratio of wine is 1:87 after rhizoma polygonati dosage and adjustment, then stands 14h, is filtered using plate filter, filter sizes
For 1um, encapsulating obtains the sealwort health wine.
Embodiment 3
The present embodiment provides a kind of sealwort health wine, raw material components include:
Rhizoma polygonati, 60g；
Ginseng, 12g；
Fructus lycii, 24g；
Rock sugar, 300g；
Mentholum, 0.04g；
White wine, 4650g.
Further, the present embodiment provides the preparation method of the sealwort health wine, include the following steps:
(1) the closed extraction of fen-flavor type white spirit for being 45%vol with Alcohol degree by above-mentioned parts by weight rhizoma polygonati, ginseng and fructus lycii
10 days, raw material and quality of white spirit ratio were 1:8, and filtering obtains leaching liquor and filter residue；
(2) filter residue being squeezed, press juice merges with the leaching liquor, it is filtered using 120 mesh stainless steel filtering nets,
Obtain former wine；
(3) pure water of 1/3 mass is added into rock sugar, tanning is syrup at 90 DEG C, gained syrup is added to described
It is stirred in former wine, mixing speed 40r/min, mixing time 15min obtains sugaring former wine；
(4) white wine of 8 times of quality of Mentholum is dissolved, is added in the sugaring former wine and stirs, mixing speed is
40r/min, mixing time 25min obtain Mentholum former wine；
(5) the Mentholum former wine Alcohol degree is adjusted to 36%vol with white wine and pure water, be adjusted rear wine, Huang
The mass ratio of wine is 1:84 after smart dosage and adjustment, then stands 12h, is filtered using plate filter, filter sizes are
0.6um, encapsulating obtain the sealwort health wine.
Experimental example
One, index parameter
The determination of 1 organoleptic indicator of table
| Project | Index | Formulate foundation | Employing mode | The method of inspection |
| Color | Clear, rufous | Product actual measurement | Range estimation | Range estimation |
| Flavour, smell | Gas faint scent, it is slightly sweet | Product actual measurement | Nose is heard, mouth is tasted | Nose is heard, mouth is tasted |
| Character | Wine | Product actual measurement | Range estimation | Range estimation |
| Impurity | Allow to have a small amount of precipitating | Product actual measurement | Range estimation | Range estimation |
Organoleptic analysis is carried out to sealwort health wine of the present invention using method in table 1, it is good to can be obtained product of the present invention mouthfeel, fragrant
Gas is coordinated, and the various age groups that have certain requirements to alcohol content and healthcare function are suitble to.
The determination of 2 physical and chemical index of table
Available by data in 2, sealwort health wine alcoholic strength of the present invention is 35.0 ± 3%vol, and total sugar content is
66.6g/L, sugar-free extract 1.7g/L, total acid content 0.04866g/L, total ester content 1.46g/L, lead content be≤
0.5。
The determination of the significant component target of table 3
Available, sealwort health wine general flavone content >=13.57mg/100mL of the present invention, total soap by data in 3
Glycosides content >=13.06mg/100mL.
4 net content deviation of table
| Project | Index | Formulate foundation | Employing mode | The method of inspection |
| Allowed minus deviation, % | 3 | JJF1070 | It is strict in national standard | JJF1070 |
By available in table 4, it is tight that the minus deviation that sealwort health wine net content of the present invention allows, which is 3%,
In national standard, it can guarantee the quality of product of the present invention.
1, the specific measuring method of physical and chemical index parameter:
1.1 alcoholic strengths (alcohol meter method)
1.1.1 principle
With the involatile substance in way of distillation removal sample, alcohol by volume score indicating value is measured with alcohol meter method, is subject to
Temperature correction, the volume fraction of ethyl alcohol, i.e. alcoholic strength at ask 20 DEG C.
1.1.2 instrument
1.1.2.1 alcohol meter: scale division value is 0.1 °.
1.1.2.2 full glass distiller: 1000mL.
1.1.3 the preparation of sample
500mL sample (20 DEG C of liquid temperature) is accurately measured in 1000mL cucurbit with a clean, dry 500mL volumetric flask
In, with 50mL moisture, flush volume bottle, washing lotion are fully incorporated in cucurbit three times, then plus several beades, connect condenser, with
The former volumetric flask of sampling makees receiver (additional ice bath).Open condensed water, slow heating distillation.Distillate is collected close to quarter
Degree, removes volumetric flask, Gai Sai.30min is kept the temperature in 20.0 DEG C of ± 0.1 DEG C of water-baths, water supplement to scale mixes, spare.
1.1.4 analytical procedure
Sample (1.1.3) is poured into clean, dry 500mL graduated cylinder, is stood several minutes, after wherein bubble collapse,
Be put into clean, dry alcohol meter, then gently click, must not the same wall of exposure, while being inserted into thermometer, balance 5min, water
Flat observation, reads the scale indicating value with meniscus the tangent, while recording temperature.According to the alcohol meter indicating value and temperature measured,
Alcoholic strength when being converted into 20 DEG C.
Acquired results are indicated to a decimal.
1.1.5 precision
The absolute difference of the measurement result independent twice obtained under the conditions of repeatability must not exceed arithmetic mean of instantaneous value
1%.
1.2 total reducing sugars (direct titrimetric method)
1.2.1 principle
Using Fehling's solution and reduced sugar azeotropic, the reaction of copper oxidule precipitation is generated, using methylene blue as indicator solution, with
Sample after hydrolysis titrates the Fehling's solution boiled, and when reaching terminal, slight excess of reduced sugar is by the methylene blue of blue
Be reduced to it is colourless, to show terminal.According to the content for the total reducing sugar that sample consumption is asked.
1.2.2 reagent and material
1.2.2.1 hydrochloric acid solution (1+1)
1.2.2.2 sodium hydroxide solution (200g/L)
1.2.2.3 it glucose standards solution (2.5g/L): weighs in 105 DEG C~110 DEG C drying in oven 3h and in drying
Cooling DEXTROSE ANHYDROUS 2.5g (being accurate to 0.0001g), is dissolved with water and is settled to 1000mL in device.
1.2.2.4 methylene blue indicator solution (10g/L): 1.0g methylene blue is weighed, is dissolved with water and is settled to 100mL.
1.2.2.5 Fehling's solution (I, II)
A) it prepares
It is prepared by GB/T 603.
B) it demarcates
Preliminary experiment: Fehling's solution I, II each 5.00mL are drawn in 250mL triangular flask, adds 50mL water, shakes up, in electric furnace
On be heated to boiling, titrated under fluidized state with glucose standards solution (1.2.2.3), when the blue of solution takes on a red color disappearance
When, add 2 drop methylene blue indicator solutions, continues to drop to blue disappearance, record the volume of consumption of glucose standard solution.
Formal test: Fehling's solution I, II each 5.00mL are drawn in 250mL triangular flask, adds 50mL water and compares preliminary experiment
The glucose standards solution (1.2.2.3) of few 1mL, is heated to boiling, and keep 2min, adds 2 drop methylene blue indicator solutions, boiling
In dropping to terminal with glucose standards solution in 1min under state, the total volume (V) of consumption of glucose standard solution is recorded.
C) it calculates
The grams that Fehling's solution I, II each 5.00mL are equivalent to glucose is calculated by following formula:
In formula:
F --- Fehling's solution I, II each 5.00mL are equivalent to the grams of glucose, and unit is gram (g)；
M --- the quality of DEXTROSE ANHYDROUS is weighed, unit is gram (g)；
V --- the total volume of consumption of glucose standard solution, unit are milliliter (mL).
1.2.3 the preparation of sample
Accurately draw a certain amount of sample (V1) (20 DEG C of liquid temperature) in 100mL volumetric flask, being allowed to contained total sugar amount is
0.2g~0.4g adds 5mL hydrochloric acid solution (1.2.2.1), adds water to 20mL, shake up.In hydrolyzing 15min in (68 ± 1) DEG C water-bath,
It takes out, it is cooling.It is neutralized to neutrality with sodium hydroxide solution (1.2.2.2), temperature adjustment adds water to be settled to scale (V to 20 DEG C2), it is standby
With.
1.2.4 analytical procedure
Glucose standards solution is replaced with sample (1.2.3), by 1.2.2.5b) equally operation, the body of record consumption sample
Product (V3), as a result calculated by the formula in formula 1.2.5.
1.2.5 result calculates
In formula:
The content of X --- total reducing sugar, unit are gram per liter (g/L)；
F --- Fehling's solution I, II each 5.00mL are equivalent to the grams of glucose, and unit is gram (g)；
The volume of V1 --- pipette samples, unit are milliliter (mL)；
V2 --- after sample dilution or the volume of hydrolysis constant volume, unit are milliliter (mL)；
V3 --- the volume of consumption sample, unit are milliliter (mL).
1.2.6 precision
The absolute difference of the measurement result independent twice obtained under the conditions of repeatability must not exceed arithmetic mean of instantaneous value
2%.
1.3 sugar-free extract
1.3.1 principle
Sample is measured with density bottle method or steams the density of the sample after alcohol, then finds out total extractives with its density
Content.Subtract the content of total reducing sugar therefrom again to get the content of sugar-free extract.
1.3.2 instrument
1.3.2.1 porcelain evaporating dishes: 200mL.
1.3.2.2 water bath with thermostatic control: precision ± 0.1 DEG C.
1.3.2.3 thermometer density bottle: 25mL or 50mL is paid.
1.3.3 the preparation of sample
100mL sample (20 DEG C of liquid temperature) is measured with 100mL volumetric flask, is poured into 200mL porcelain evaporating dishes, in being evaporated in water-bath
One third to about original volume is removed, and after cooling, raffinate carefully moved into former volumetric flask, is repeatedly swung with water and wash evaporation
Ware, washing lotion are incorporated in volumetric flask, are settled to scale in 20 DEG C.
1.3.4 analytical procedure
1.3.4.1 the measurement of water quality is distilled
A) density bottle is cleaned and is dried, band thermometer and side opening cover weigh.It repeats dry and weighs, until constant weight (m).
B) thermometer is removed, the distilled water for being cooled to 15 DEG C or so will be boiled fills the density bottle of constant weight, plug thermometer,
There must not be bubble in bottle.Density bottle is immersed in 20.0 DEG C ± 0.1 DEG C of water bath with thermostatic control, to contents temperature up to 20 DEG C, and is protected
Hold 10min it is constant after, with filter paper suck side pipe spilling liquid, flush the liquid level in side pipe with side pipe nozzle, cover immediately
Side opening cover takes out density bottle, dries the water in bottle wall with filter paper, weighs (m immediately1)。
1.3.4.2 the measurement of sample mass
Water in density bottle is poured out, with sample (1.3.3) repeated flushing density bottle 3 times~5 times, then fills, presses
1.3.4.1b) same operation, weighs (m2).Density p when calculating 20 DEG C of dealcoholysis sample20, with ρ20× 1.00180 it is worth go out
The content (g/L) of total extractives.
1.3.5 result calculates
Density of the sample at 20 DEG C is calculated by formula (1), and aerostatic buoyancy corrected value is calculated by formula (2).
In formula:
ρ20--- density of the sample at 20 DEG C, unit are gram per liter (g/L)；
The quality of m --- density bottle, unit are gram (g)；
m1--- the quality of density bottle and water at 20 DEG C, unit are gram (g)；
m2--- the quality of density bottle and sample at 20 DEG C, unit are gram (g)；
ρ0--- the density (998.20g/L) of distilled water at 20 DEG C；
A --- aerostatic buoyancy corrected value；
ρμ--- density value (≈ 1.2g/L) of the dry air in 20 DEG C, 1013.25hPa；
997.0 --- the difference of distilled water and dry air density value at 20 DEG C, unit are gram per liter (g/L)；
1.00180 --- the correction factor of density bottle volume at 20 DEG C.
Acquired results are indicated to a decimal.
1.3.6 precision
The absolute difference of the measurement result independent twice obtained under the conditions of repeatability must not exceed arithmetic mean of instantaneous value
2%.
1.4 total acids (indicator method)
1.4.1 principle
It is titrated with phenolphthalein indicator with alkali standard solution using acid base titration principle, total acid is calculated according to the dosage of alkali
Content.
1.4.2 reagent and material
1.4.2.1 standard solution of sodium hydroxide [c (NaOH)=0.05mol/L]: being prepared and demarcated by GB/T 601, and quasi-
Really dilution.
1.4.2.2 it instructions phenolphthalein solution (10g/L): is prepared by GB/T 603.
1.4.3 analytical procedure
Pipette samples 2mL~5mL (20 DEG C of liquid temperature), is placed in 250m/L triangular flask, and 50m/L water is added, while 2 drops are added
Instructions phenolphthalein solution after shaking up, immediately to terminal with Standard Volumetric Solutions for Sodium Hydroxide titration, and keeps non-discolouring in 30s, writes down
Consume the volume (V of Standard Volumetric Solutions for Sodium Hydroxide1).Blank test is done simultaneously.
1.4.4 result calculates
The content of total acid is calculated by formula following formula in sample.
In formula:
X --- the content (with Acetometer) of total acid in sample, unit are gram per liter (g/L)；
The concentration of c --- Standard Volumetric Solutions for Sodium Hydroxide, unit are mole every liter (mol/L)；
V0--- blank test consumes the volume of Standard Volumetric Solutions for Sodium Hydroxide, and unit is milliliter (mL)
V1--- sample drop timing consumes the volume of Standard Volumetric Solutions for Sodium Hydroxide, and unit is milliliter (mL)
V2--- the volume of pipette samples, unit are milliliter (mL)
60 --- the numerical value of the molal weight of acetic acid, unit are gram every mole (g/mol)
1.4.6 precision
The absolute difference of the measurement result independent twice obtained under the conditions of repeatability must not exceed arithmetic mean of instantaneous value
3%.
1.5 total esters (indicator method)
1.5.1 principle
With the free acid in alkali neutralization sample, then a certain amount of alkali is accurately added, being heated to reflux is saponified esters.By disappearing
The meter of consumption alkali calculates the content of total ester.
1.5.2 instrument
1.5.2.1 full glass distiller: 500mL；
1.5.2.2 full glass refluxing unit: Backflow bottle 1000mL, 250mL；
1.5.2.3 base buret: 25mL；
1.5.2.4 acid buret: 25mL；
1.5.3 reagent and solution
1.5.3.1 it Standard Volumetric Solutions for Sodium Hydroxide [c (NaOH)=0.1mol/L]: prepares and demarcates by GB/T 601.
1.5.3.2 it standard solution of sodium hydroxide [c (NaOH)=3.5mol/L]: is prepared by GB/T 601.
1.5.3.3 sulfuric acid standard titration solution [c (1/2H2SO4)=0.1mol/L]: it prepares and demarcates by GB/T 601.
1.5.3.4 ethyl alcohol (no ester) solution [40% (volume fraction)]: 95% ethyl alcohol 600mL is measured in 1000mL Backflow bottle
In (1.5.2.2), adding sodium hydroxide standard solution (1.5.3.2) 5mL is heated to reflux saponification 1h.Then move into weight in distiller
It steams, then is made into 40% (volume fraction) ethanol solution.
1.5.3.5 it phenolphthalein indicator (10g/L): is prepared by GB/T 603.
1.5.4 analytical procedure
Pipette samples 50.0mL adds 2 drop phenolphthalein indicators (1.5.3.5), in 250mL Backflow bottle with sodium hydroxide standard
Titration solution (1.5.3.1) is titrated to pink, ml of record consumption Standard Volumetric Solutions for Sodium Hydroxide.It is accurate again to be added
Standard Volumetric Solutions for Sodium Hydroxide (1.5.3.1) 25.00mL, shakes up, is put into zeolite, load onto condenser pipe, in flowing back on boiling water bath
30min is removed, cooling.Then, it is titrated with sulfuric acid standard titration solution (1.5.3.3), completely disappears blush just
For its terminal, the volume of record consumption sulfuric acid standard titration solution.Ethyl alcohol (no ester) solution (1.5.3.4) 50mL is drawn simultaneously,
Blank test, the volume of record consumption sulfuric acid standard titration solution are done in same operation according to the above method.
1.5.5 result calculates
Total ester content is calculated according to following formula in sample.
In formula:
X --- the mass concentration (in terms of ethyl acetate) of total ester in sample, unit are gram per liter (g/L)；
C --- the actual concentrations of sulfuric acid standard titration solution, unit are mole every liter (mol/L)；
V0--- blank test sample consumes the volume of sulfuric acid standard titration solution, and unit is milliliter (mL)；
V1--- the volume of sample consumption sulfuric acid standard titration solution, unit are milliliter (mL)；
88 --- the numerical value of the molal weight of ethyl acetate, unit are gram every mole (g/mol)；
50.0 --- the volume of pipette samples, unit are milliliter (mL).
1.5.6 precision
The absolute difference of the measurement result independent twice obtained under the conditions of repeatability must not exceed arithmetic mean of instantaneous value
2%.
2. the significant specific measuring method of component target parameter
2.1 general flavone detection methods: (sodium nitrite-aluminum nitrate development process)
2.1.1 principle
It can be with Al when having free 3-OH, 5-OH or adjacent two phenolic hydroxyl group in flavone compound molecule3+、Zr4+、Pb2+Etc. shapes
It develops the color at complex, this property can be used for the qualitative and quantitative analysis of flavone compound.
2.1.2 instrument and reagent
Instrument: Ultra-3660 ultraviolet-uisible spectrophotometer；Cuvette (1cm).
Reagent: rutin standard items (lot number: 100080-200306: Nat'l Pharmaceutical & Biological Products Control Institute)；Sodium nitrite,
Aluminum nitrate, sodium hydroxide, methanol etc. are that analysis is pure.
2.1.3 preparation of reagents
5%NaNO2Preparation
Precision weighs NaNO22.5g, distilled water dissolve and are settled to 50mL, face with now matching.
10%Al (NO3)3Preparation
Precision weighs Al (NO3)35g, distilled water dissolve and are settled to 50mL, face with now matching.
The preparation of 4%NaOH
Precision weighs NaOH 4g, and distilled water dissolves and is settled to 100mL.
75% methanol is prepared
By distilled water and methanol in the ratio of 1:3 mix to get.
2.1.4 method and result
2.1.4.1 the preparation of reference substance solution
Precision weighs the dry 36h control substance of Rutin 10.95mg in phosphorus pentoxide vacuum drying apparatus, sets 50mL volumetric flask
In, 75% methanol dissolution after be settled to scale to get.
2.1.4.2 the determination of Detection wavelength
Precision draws reference substance solution 6.0mL, until 5%NaNO is added in 25mL volumetric flask2Solution 1mL is stood after shaking up
6min；Add 10%Al (NO3)3Solution 1mL stands 6min after shaking up；Add 4%NaOH solution 10mL, adds water to be settled to scale, shake
15min is stood after even.UV, visible light spectrophotometer full wavelength scanner the results show that reference substance solution at 505nm wavelength
It shows compared with strong absworption peak, therefore selected 505nm is as Detection wavelength.
2.1.4.3 the foundation of standard curve
Accurate control substance of Rutin solution 0.0,1.0,2.0,3.0,4.0,5.0, the 6.0mL of drawing is in 25mL volumetric flask respectively
In, addition distilled water to 6mL, using first part as blank control, is surveyed by step operation under " 2.1.4.2 " item at 505nm
The absorbance value of fixed each reference substance solution, absorbance value is respectively 0.0968,0.1966,0.2915,0.4003,0.4953,
0.6142.With absorbance value (A) for ordinate, rutin reference solution concentration (C) is abscissa, draws standard curve, obtains line
Property regression equation are as follows: A=11.715C-0.0101 (R2=0.999), the results showed that rutin is in 8.76mgL-1~
52.56mg·L-1It is in good linear relationship in concentration range.
2.1.4.4 sample treatment and assay
Sample is shaken up into accurate absorption 20mL, is placed in evaporating dish, 90 DEG C of water bath methods, the dissolution of 75% methanol, filtering is simultaneously
It is settled to 50mL, then accurate absorption 12mL measures its absorbance value by step operation under " 2.1.4.2 " item at 505nm, puts down
Three groups of row measurement, calculate in sample general flavone average content be 13.57mg/100mL.
2.2 total saposins detection methods (vanillic aldehyde-perchloric acid colorimetric method)
2.2.1 principle
After sample is dissolved with methanol aqueous solution, it is hydrolyzed into aglycon in acid condition, reacts aobvious with vanillic aldehyde, perchloric acid
Color.
2.2.2 instrument and reagent
Instrument: Ultra-3660 ultraviolet-uisible spectrophotometer；Cuvette (1cm).
Reagent: ginsenoside Re's standard items (Nat'l Pharmaceutical & Biological Products Control Institute)；Vanillic aldehyde, glacial acetic acid, perchloric acid, first
Alcohol is that analysis is pure.
2.2.3 preparation of reagents
The preparation of 5% vanillic aldehyde-glacial acetic acid solution
Precision weighs 500mg vanillic aldehyde and is dissolved in 10mL glacial acetic acid, Fresh.
2.2.4 method and result
2.2.4.1 the preparation of reference substance solution
Precision weighs ginsenoside Re reference substance 8.44mg, sets in 25mL volumetric flask, is settled to scale after adding methanol to dissolve,
To obtain the final product.
2.2.4.2 the determination of Detection wavelength
Appropriate reference substance solution is drawn in 10mL tool plug test tube, methanol is flung in water-bath, adds 5% vanillic aldehyde-glacial acetic acid
Solution 0.2mL, perchloric acid 0.8mL, shakes up, and sets in 60 DEG C of water-baths and heats 15min, sets cooling in ice-water bath, addition ice vinegar immediately
Sour 5.0mL, shakes up, using corresponding reagent as blank, UV, visible light spectrophotometer full wavelength scanner the results show that reference substance
Solution is shown at 545nm wavelength compared with strong absworption peak, therefore selected 545nm is as Detection wavelength.
2.2.4.3 the foundation of standard curve
It is accurate respectively to draw ginsenoside Re's reference substance solution 0.0,0.1,0.2,0.3,0.4,0.5,0.6mL, it is placed in
In 10mL tool plug test tube, by step operation under " 2.2.4.2 " item, using first part as blank control, it is each right to measure at 545nm
According to the absorbance value of product solution, absorbance value is respectively 0.1572,0.3311,0.4793,0.6461,0.7911,0.9557.With
Absorbance value (A) is ordinate, and ginsenoside Re's reference substance solution concentration (C) is abscissa, draws standard curve, obtains and linearly return
Return equation are as follows: A=28.126C+0.0062 (R2=0.9995), the results showed that rutin is in 5.627mgL-1~33.762mg
It is in good linear relationship in L-1 concentration range.
2.2.4.4 sample treatment and assay
Sample is shaken up into accurate absorption 1mL and measures its absorbance at 545nm by step operation under " 2.2.4.2 " item
Value is measured in parallel three groups, calculate in sample total saposins average content be 13.06mg/100mL.
Two, the health-care effect test of sealwort health wine described in embodiment 3
By 326 with hypoimmunity, the symptoms such as qi and blood is unsmooth, high cholesterol, tired mind and body fatiguability
People, of all ages, gender is randomly divided into two groups, and every group of 163 people, respectively experimental group and control group allow subject to drink respectively
Drink is tested with corresponding, the health situation of change of study subject is observed after three months.
Experimental group: allowing study subject to drink sealwort health wine of the present invention at daily noon, one glass every time, observes tested
The situation of change of subject's body health；
Control group: the white wine for allowing study subject to drink non-present invention with degree at daily noon, is observed tested by one glass every time
The situation of change of subject's body health；
After the various periods of time for approval, to improve substantially without improvement, slightly, improve, be obviously improved as 4 grades of evaluation criterions pair
The improvement situation of the corresponding symptom of study subject is evaluated, and the health variation of each group study subject is counted.As a result such as
Shown in table 5:
5 test result of table
| Group | Substantially without improvement | Slightly improve | Improve | It is obviously improved | It is efficient |
| Experimental group | 3 | 3 | 65 | 92 | 98.1% |
| Control group | 149 | 14 | 0 | 0 | 0.91% |
It can be seen from the above result that experimental group study subject health result of variations is most obvious, illustrate that experimental group is tested right
As drinking sealwort health wine of the present invention, immunity of organisms is significantly improved, and qi and blood is unsmooth, high cholesterol, tired mind
Obviously occur improving with symptoms such as body fatiguabilities, also sufficiently demonstrates the health-care efficacy of health liquor of the present invention.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of sealwort health wine, which is characterized in that raw material components include:
Rhizoma polygonati, 48-72 parts by weight；
Ginseng, 9-15 parts by weight；
Fructus lycii, 19-29 parts by weight；
Rock sugar, 250-350 parts by weight；
Mentholum, 0.02-0.06 parts by weight；
White wine, 4580-5420 parts by weight.
2. sealwort health wine according to claim 1, which is characterized in that raw material components include:
Rhizoma polygonati, 60 parts by weight；
Ginseng, 12 parts by weight；
Fructus lycii, 24 parts by weight；
Rock sugar, 300 parts by weight；
Mentholum, 0.04 parts by weight；
White wine, 4650 parts by weight.
3. the preparation method of any one of the claim 1-2 sealwort health wine, which comprises the following steps:
(1) by the closed extraction of white wine of above-mentioned parts by weight rhizoma polygonati, ginseng and fructus lycii, filtering obtains leaching liquor and filter residue；
(2) filter residue is squeezed, press juice merges with the leaching liquor, and filtering obtains former wine；
(3) pure water is added into rock sugar, boils as syrup, gained syrup is added in the former wine, is stirred evenly, is obtained
Sugaring former wine；
(4) Mentholum is dissolved with white wine, is added in the sugaring former wine, stirs evenly, obtains Mentholum former wine；
(5) the Mentholum former wine Alcohol degree is adjusted with white wine and pure water, is adjusted rear wine；Then to the adjustment after
Wine is stood, is filtered, encapsulating obtains the sealwort health wine.
4. the preparation method of sealwort health wine according to claim 3, which is characterized in that in step (1), the white wine is wine
Precision number is the fen-flavor type white spirit of 43-48%vol；Raw material and quality of white spirit ratio are 1:(6-10)；Extraction time is 8-12 days.
5. the preparation method of sealwort health wine according to claim 3, which is characterized in that in step (2), filter operation is used
The filtering of 100-150 mesh stainless steel filtering net.
6. the preparation method of sealwort health wine according to claim 3, which is characterized in that in step (3), rock sugar and pure water
Mass ratio be (2.5-3.3): 1；Boiling temperature is 80-110 DEG C.
7. the preparation method of sealwort health wine according to claim 3, which is characterized in that in step (3), mixing speed is
25-60r/min, mixing time 10-20min.
8. the preparation method of sealwort health wine according to claim 3, which is characterized in that in step (4), Mentholum and white wine
Mass ratio be 1:(6-10)；Mixing speed is 25-60r/min, mixing time 20-30min.
9. the preparation method of sealwort health wine according to claim 3, which is characterized in that in step (5), by Mentholum former wine
Alcohol degree is adjusted to 32-38%vol, and the mass ratio of wine is 1:(80-87 after rhizoma polygonati dosage and adjustment)；Time of repose is 10-
14h。
10. the preparation method of sealwort health wine according to claim 3, which is characterized in that in step (5), utilize sheet frame mistake
Filter is filtered, filter sizes 0.1-1um.
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| CN111346176A (en) * | 2020-04-23 | 2020-06-30 | 唐荣成 | Miao medicine composition for treating fracture and preparation method thereof |
| CN111407852A (en) * | 2020-04-23 | 2020-07-14 | 唐荣成 | Miao medicine composition for treating cervical spondylosis and preparation method thereof |
| CN111450193A (en) * | 2020-04-23 | 2020-07-28 | 唐荣成 | Miao medicine composition for treating gout and preparation method thereof |
| CN112704711A (en) * | 2021-02-19 | 2021-04-27 | 北京鹤年堂中医医院管理(集团)有限公司 | Mulberry leaf and rhizoma polygonati kidney tonifying paste and preparation method thereof |
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