CN109320991A - A kind of preparation method of medical infusion antibacterial hose - Google Patents
A kind of preparation method of medical infusion antibacterial hose Download PDFInfo
- Publication number
- CN109320991A CN109320991A CN201811186013.7A CN201811186013A CN109320991A CN 109320991 A CN109320991 A CN 109320991A CN 201811186013 A CN201811186013 A CN 201811186013A CN 109320991 A CN109320991 A CN 109320991A
- Authority
- CN
- China
- Prior art keywords
- hose
- parts
- medical infusion
- added
- antibacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000001802 infusion Methods 0.000 title claims abstract description 25
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 49
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims abstract description 22
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims abstract description 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 20
- 238000003756 stirring Methods 0.000 claims abstract description 20
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 238000005253 cladding Methods 0.000 claims abstract description 18
- -1 polypropylene Polymers 0.000 claims abstract description 12
- 229920001661 Chitosan Polymers 0.000 claims abstract description 11
- 239000004743 Polypropylene Substances 0.000 claims abstract description 11
- KZBSIGKPGIZQJQ-UHFFFAOYSA-N bis(2-butoxyethyl) decanedioate Chemical compound CCCCOCCOC(=O)CCCCCCCCC(=O)OCCOCCCC KZBSIGKPGIZQJQ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000012188 paraffin wax Substances 0.000 claims abstract description 11
- 229920001155 polypropylene Polymers 0.000 claims abstract description 11
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229910021529 ammonia Inorganic materials 0.000 claims abstract description 10
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 10
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 10
- 238000000748 compression moulding Methods 0.000 claims abstract description 10
- 238000002347 injection Methods 0.000 claims abstract description 10
- 239000007924 injection Substances 0.000 claims abstract description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 10
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims abstract description 10
- 229920000915 polyvinyl chloride Polymers 0.000 description 9
- 239000004800 polyvinyl chloride Substances 0.000 description 9
- 230000003115 biocidal effect Effects 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 5
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000004014 plasticizer Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- HGUFODBRKLSHSI-UHFFFAOYSA-N 2,3,7,8-tetrachloro-dibenzo-p-dioxin Chemical compound O1C2=CC(Cl)=C(Cl)C=C2OC2=C1C=C(Cl)C(Cl)=C2 HGUFODBRKLSHSI-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000004803 Di-2ethylhexylphthalate Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 206010043275 Teratogenicity Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000012760 heat stabilizer Substances 0.000 description 1
- 231100000003 human carcinogen Toxicity 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000211 teratogenicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B1/00—Layered products having a non-planar shape
- B32B1/08—Tubular products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/28—Layered products comprising a layer of synthetic resin comprising synthetic resins not wholly covered by any one of the sub-groups B32B27/30 - B32B27/42
- B32B27/285—Layered products comprising a layer of synthetic resin comprising synthetic resins not wholly covered by any one of the sub-groups B32B27/30 - B32B27/42 comprising polyethers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L101/00—Compositions of unspecified macromolecular compounds
- C08L101/12—Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/10—Homopolymers or copolymers of propene
- C08L23/12—Polypropene
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/714—Inert, i.e. inert to chemical degradation, corrosion
- B32B2307/7145—Rot proof, resistant to bacteria, mildew, mould, fungi
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2535/00—Medical equipment, e.g. bandage, prostheses, catheter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2597/00—Tubular articles, e.g. hoses, pipes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2286—Oxides; Hydroxides of metals of silver
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/014—Additives containing two or more different additives of the same subgroup in C08K
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/08—Stabilised against heat, light or radiation or oxydation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/18—Applications used for pipes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2207/00—Properties characterising the ingredient of the composition
- C08L2207/04—Thermoplastic elastomer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of preparation method of medical infusion antibacterial hose, and polyethylene glycol 200 and ethylene glycol monobutyl ether are mixed, stirs evenly, obtains mixed liquor A；It takes TPE to be added in mixed liquor A, is heated to 60-80 DEG C under conditions of protection of ammonia, 25-35min is stirred with 400-600r/min；Chitosan and nano phase ag_2 o is then added, continues to stir 30-50min with 1000-1500r/min, obtains hose inner layer material；Paraffin, tributyl citrate and dibutoxy ethyl sebacate are mixed, 100-150 DEG C is heated under the conditions of nitrogen protection, state is stirred until homogeneous with 500-600r/min, obtains mixed liquid B；It takes polypropylene to be added in mixed liquid B, adds antioxidant B900, at 50-70 DEG C of temperature, 40-70min is stirred to react with 600-800r/min, obtains hose cladding material；By in hose cladding material and hose inner layer material injection model, at 200-250 DEG C of temperature, is squeezed out, compression moulding, the medical infusion antibacterial hose can be obtained.
Description
Technical field
The present invention relates to the preparation technical fields of hose, and in particular to a kind of preparation method of medical infusion antibacterial hose.
Background technique
What the material of traditional medical Transfusion device hose generallyd use is PVC(polyvinyl chloride) material, it is still, both domestic and external
Service condition and research data show: there is damage to human health and environment in Corvic and its additive DE HP.
1987, vinyl chloride was determined as human carcinogen by International Cancer Research Institute.Either when Corvic synthesizes, also
When being processing, vinyl chloride is always more or less generated.Research is found: Long Term Contact vinyl chloride monomer can cause neurasthenia, chlorine
The symptoms such as acne and Raynand's disease are referred to as vinyl chloride disease.
But polyvinyl chloride resin itself is a kind of noncrystalline rigid material.Therefore, the excellent processability of flexible PVC material and soft
Toughness is needed by adding a large amount of small molecule auxiliary agent (plasticizer, heat stabilizer, antioxidant, filler, lubricant, colorant
And modifier) realize.Wherein, phthalic acid two (2- ethylhexyl) esters (DEHP) plasticizer is that dosage is maximum
It is a kind of.Due to the compatibility of plasticizer and resin deficiency, it can be precipitated from polyvinyl chloride resin in use, animal is caused
Teratogenicity mutagenesis.In addition, the recuperability of PVC is poor, hydrogen chloride and other pernicious gases can be released in burning
Such as dioxin, environmental pollution is caused.Therefore, PVC causes people and more and more pays close attention in the application of medical treatment and field of food
And discussion.Wherein, use is additive-free, non-PVC (Non-PVC) base new material replaces PVC to have become trend.
Summary of the invention
The purpose of the present invention is the deficiencies for hose material performance in the prior art, and it is soft to provide a kind of medical infusion antibacterial
The preparation method of pipe promotes it more preferably to apply to improve antibacterial, the appropriateness performances such as soft or hard, stability of hose.
In order to achieve the above objectives, the technical solution adopted by the present invention is that:
A kind of preparation method of medical infusion antibacterial hose, includes the following steps:
S1: polyethylene glycol 200 and ethylene glycol monobutyl ether are mixed according to volume ratio 1-3:1, stirs evenly, obtains mixed liquor A；
S2: it takes 30-60 parts of TPE to be added in mixed liquor A described in 25-35 parts of step S1, is heated to 60- under conditions of protection of ammonia
80 DEG C, 25-35min is stirred with 400-600r/min；2-4 parts of chitosans and 1-3 parts of nano phase ag_2 os are added, then with 1000-
1500r/min continues to stir 30-50min, obtains hose inner layer material；
S3: paraffin, tributyl citrate and dibutoxy ethyl sebacate are mixed according to volume ratio 3:2:1-3, protected in nitrogen
It is heated to 100-150 DEG C under the conditions of shield, state is stirred until homogeneous with 500-600r/min, obtains mixed liquid B；
S4: taking 30-40 parts of polypropylene to be added in mixed liquid B described in 15-20 parts of step S3, add 1-3 parts of antioxidant B900,
At 50-70 DEG C of temperature, 40-70min is stirred to react with 600-800r/min, obtains hose cladding material；
S5: by hose cladding material and hose inner layer material according in 1-2:1 injection model, at 200-250 DEG C of temperature, through squeezing
Out, the medical infusion antibacterial hose can be obtained in compression moulding.
Preferably, the volume ratio 2.5:1 of polyethylene glycol 200 described in step S1 and ethylene glycol monobutyl ether.
Preferably, 45 parts of TPE are taken to be added in mixed liquor A described in 30 parts of step S1 described in step S2, in protection of ammonia
Under the conditions of be heated to 75 DEG C, with 500r/min stir 30min.
Preferably, 3 parts of chitosans and 2 parts of nano phase ag_2 os are added described in step S2, continue to stir with 1200r/min
45min。
Preferably, the volume ratio 3:2 of paraffin described in step S3, tributyl citrate and dibutoxy ethyl sebacate:
2；It is heated to 130 DEG C under the conditions of nitrogen protection, state is stirred until homogeneous with 550r/min.
Preferably, it takes 35 parts of polypropylene to be added in mixed liquid B described in 17 parts of step S3 in step S4, adds 2 parts of antioxygens
Agent B900 is stirred to react 50min at 65 DEG C of temperature with 700r/min.
Preferably, hose cladding material described in step S5 and hose inner layer material are according in 1.3:1 injection model, in temperature
At 230 DEG C of degree, squeezed out, compression moulding.
The utility model has the advantages that
A kind of preparation method of medical infusion antibacterial hose of the present invention, is prepared into TPE combination chitosan, nano phase ag_2 o
To hose inner layer material, it is prepared with polypropylene and paraffin/tributyl citrate/dibutoxy ethyl sebacate mixed liquor soft
Outer tube layer material, after be injected into model, extrusion, compression moulding according to the proportion after obtain medical infusion antibacterial hose；The present invention
Hose can make internal layer have certain intensity so that guarantee in infusion process will not be because the folding of hose influences infusion process, outer layer
It with certain flexibility, is broken off to avoid hose, liquid leaks out；Antibiotic property, ageing-resistant, stability are effectively increased simultaneously
Deng.
Specific embodiment
Further illustrate that the present invention, following embodiments are merely to illustrate the present invention below in conjunction with following embodiments, and
The unrestricted present invention.
Embodiment 1
S1: polyethylene glycol 200 and ethylene glycol monobutyl ether are mixed according to volume ratio 1-3:1, stirs evenly, obtains mixed liquor A；
S2: it takes 30-60 parts of TPE to be added in mixed liquor A described in 25-35 parts of step S1, is heated to 60- under conditions of protection of ammonia
80 DEG C, 25-35min is stirred with 400-600r/min；2-4 parts of chitosans and 1-3 parts of nano phase ag_2 os are added, then with 1000-
1500r/min continues to stir 30-50min, obtains hose inner layer material；
S3: paraffin, tributyl citrate and dibutoxy ethyl sebacate are mixed according to volume ratio 3:2:1-3, protected in nitrogen
It is heated to 100-150 DEG C under the conditions of shield, state is stirred until homogeneous with 500-600r/min, obtains mixed liquid B；
S4: taking 30-40 parts of polypropylene to be added in mixed liquid B described in 15-20 parts of step S3, add 1-3 parts of antioxidant B900,
At 50-70 DEG C of temperature, 40-70min is stirred to react with 600-800r/min, obtains hose cladding material；
S5: by hose cladding material and hose inner layer material according in 1-2:1 injection model, at 200-250 DEG C of temperature, through squeezing
Out, the medical infusion antibacterial hose can be obtained in compression moulding.
The antibiotic rate (Escherichia coli) of the hose material reaches 96.5%, and elongation is kept after product ultraviolet light 2500h
98% or more rate.
Embodiment 2
S1: polyethylene glycol 200 and ethylene glycol monobutyl ether are mixed according to volume ratio 1-3:1, stirs evenly, obtains mixed liquor A；
S2: it takes 30-60 parts of TPE to be added in mixed liquor A described in 25-35 parts of step S1, is heated to 60- under conditions of protection of ammonia
80 DEG C, 25-35min is stirred with 400-600r/min；2-4 parts of chitosans and 1-3 parts of nano phase ag_2 os are added, then with 1000-
1500r/min continues to stir 30-50min, obtains hose inner layer material；
S3: paraffin, tributyl citrate and dibutoxy ethyl sebacate are mixed according to volume ratio 3:2:1-3, protected in nitrogen
It is heated to 100-150 DEG C under the conditions of shield, state is stirred until homogeneous with 500-600r/min, obtains mixed liquid B；
S4: taking 30-40 parts of polypropylene to be added in mixed liquid B described in 15-20 parts of step S3, add 1-3 parts of antioxidant B900,
At 50-70 DEG C of temperature, 40-70min is stirred to react with 600-800r/min, obtains hose cladding material；
S5: by hose cladding material and hose inner layer material according in 1-2:1 injection model, at 200-250 DEG C of temperature, through squeezing
Out, the medical infusion antibacterial hose can be obtained in compression moulding.
The antibiotic rate (Escherichia coli) of the hose material reaches 97%, percent retention of elongation after product ultraviolet light 2500h
98% or more.
Embodiment 3
S1: polyethylene glycol 200 and ethylene glycol monobutyl ether are mixed according to volume ratio 1-3:1, stirs evenly, obtains mixed liquor A；
S2: it takes 30-60 parts of TPE to be added in mixed liquor A described in 25-35 parts of step S1, is heated to 60- under conditions of protection of ammonia
80 DEG C, 25-35min is stirred with 400-600r/min；2-4 parts of chitosans and 1-3 parts of nano phase ag_2 os are added, then with 1000-
1500r/min continues to stir 30-50min, obtains hose inner layer material；
S3: paraffin, tributyl citrate and dibutoxy ethyl sebacate are mixed according to volume ratio 3:2:1-3, protected in nitrogen
It is heated to 100-150 DEG C under the conditions of shield, state is stirred until homogeneous with 500-600r/min, obtains mixed liquid B；
S4: taking 30-40 parts of polypropylene to be added in mixed liquid B described in 15-20 parts of step S3, add 1-3 parts of antioxidant B900,
At 50-70 DEG C of temperature, 40-70min is stirred to react with 600-800r/min, obtains hose cladding material；
S5: by hose cladding material and hose inner layer material according in 1-2:1 injection model, at 200-250 DEG C of temperature, through squeezing
Out, the medical infusion antibacterial hose can be obtained in compression moulding.
The antibiotic rate (Escherichia coli) of the hose material reaches 97.6%, and elongation is kept after product ultraviolet light 2500h
98% or more rate.
Embodiment 4
S1: polyethylene glycol 200 and ethylene glycol monobutyl ether are mixed according to volume ratio 1-3:1, stirs evenly, obtains mixed liquor A；
S2: it takes 30-60 parts of TPE to be added in mixed liquor A described in 25-35 parts of step S1, is heated to 60- under conditions of protection of ammonia
80 DEG C, 25-35min is stirred with 400-600r/min；2-4 parts of chitosans and 1-3 parts of nano phase ag_2 os are added, then with 1000-
1500r/min continues to stir 30-50min, obtains hose inner layer material；
S3: paraffin, tributyl citrate and dibutoxy ethyl sebacate are mixed according to volume ratio 3:2:1-3, protected in nitrogen
It is heated to 100-150 DEG C under the conditions of shield, state is stirred until homogeneous with 500-600r/min, obtains mixed liquid B；
S4: taking 30-40 parts of polypropylene to be added in mixed liquid B described in 15-20 parts of step S3, add 1-3 parts of antioxidant B900,
At 50-70 DEG C of temperature, 40-70min is stirred to react with 600-800r/min, obtains hose cladding material；
S5: by hose cladding material and hose inner layer material according in 1-2:1 injection model, at 200-250 DEG C of temperature, through squeezing
Out, the medical infusion antibacterial hose can be obtained in compression moulding.
The antibiotic rate (Escherichia coli) of the hose material reaches 98.3%, and elongation is kept after product ultraviolet light 2500h
98% or more rate.
Embodiment 5
S1: polyethylene glycol 200 and ethylene glycol monobutyl ether are mixed according to volume ratio 1-3:1, stirs evenly, obtains mixed liquor A；
S2: it takes 30-60 parts of TPE to be added in mixed liquor A described in 25-35 parts of step S1, is heated to 60- under conditions of protection of ammonia
80 DEG C, 25-35min is stirred with 400-600r/min；2-4 parts of chitosans and 1-3 parts of nano phase ag_2 os are added, then with 1000-
1500r/min continues to stir 30-50min, obtains hose inner layer material；
S3: paraffin, tributyl citrate and dibutoxy ethyl sebacate are mixed according to volume ratio 3:2:1-3, protected in nitrogen
It is heated to 100-150 DEG C under the conditions of shield, state is stirred until homogeneous with 500-600r/min, obtains mixed liquid B；
S4: taking 30-40 parts of polypropylene to be added in mixed liquid B described in 15-20 parts of step S3, add 1-3 parts of antioxidant B900,
At 50-70 DEG C of temperature, 40-70min is stirred to react with 600-800r/min, obtains hose cladding material；
S5: by hose cladding material and hose inner layer material according in 1-2:1 injection model, at 200-250 DEG C of temperature, through squeezing
Out, the medical infusion antibacterial hose can be obtained in compression moulding.
The antibiotic rate (Escherichia coli) of the hose material reaches 98.9%, and elongation is kept after product ultraviolet light 2500h
98% or more rate.
The foregoing is merely better embodiment of the invention, protection scope of the present invention is not with above embodiment
Limit, as long as those of ordinary skill in the art's equivalent modification or variation made by disclosure according to the present invention, should all be included in power
In the protection scope recorded in sharp claim.
Claims (7)
1. a kind of preparation method of medical infusion antibacterial hose, which comprises the steps of:
S1: polyethylene glycol 200 and ethylene glycol monobutyl ether are mixed according to volume ratio 1-3:1, stirs evenly, obtains mixed liquor A；
S2: it takes 30-60 parts of TPE to be added in mixed liquor A described in 25-35 parts of step S1, is heated to 60- under conditions of protection of ammonia
80 DEG C, 25-35min is stirred with 400-600r/min；2-4 parts of chitosans and 1-3 parts of nano phase ag_2 os are added, then with 1000-
1500r/min continues to stir 30-50min, obtains hose inner layer material；
S3: paraffin, tributyl citrate and dibutoxy ethyl sebacate are mixed according to volume ratio 3:2:1-3, protected in nitrogen
It is heated to 100-150 DEG C under the conditions of shield, state is stirred until homogeneous with 500-600r/min, obtains mixed liquid B；
S4: taking 30-40 parts of polypropylene to be added in mixed liquid B described in 15-20 parts of step S3, add 1-3 parts of antioxidant B900,
At 50-70 DEG C of temperature, 40-70min is stirred to react with 600-800r/min, obtains hose cladding material；
S5: by hose cladding material and hose inner layer material according in 1-2:1 injection model, at 200-250 DEG C of temperature, through squeezing
Out, the medical infusion antibacterial hose can be obtained in compression moulding.
2. a kind of preparation method of medical infusion antibacterial hose according to claim 1, which is characterized in that institute in step S1
State the volume ratio 2.5:1 of polyethylene glycol 200 and ethylene glycol monobutyl ether.
3. a kind of preparation method of medical infusion antibacterial hose according to claim 1, which is characterized in that institute in step S2
It states and 45 parts of TPE is taken to be added in mixed liquor A described in 30 parts of step S1, be heated to 75 DEG C, under conditions of protection of ammonia with 500r/
Min stirs 30min.
4. a kind of preparation method of medical infusion antibacterial hose according to claim 1, which is characterized in that institute in step S2
It states and 3 parts of chitosans and 2 parts of nano phase ag_2 os is added, continue to stir 45min with 1200r/min.
5. a kind of preparation method of medical infusion antibacterial hose according to claim 1, which is characterized in that institute in step S3
State the volume ratio 3:2:2 of paraffin, tributyl citrate and dibutoxy ethyl sebacate；It is heated under the conditions of nitrogen protection
130 DEG C, state is stirred until homogeneous with 550r/min.
6. a kind of preparation method of medical infusion antibacterial hose according to claim 1, which is characterized in that taken in step S4
35 parts of polypropylene are added in mixed liquid B described in 17 parts of step S3, add 2 parts of antioxidant B900, at 65 DEG C of temperature, with
700r/min is stirred to react 50min.
7. a kind of preparation method of medical infusion antibacterial hose according to claim 1, which is characterized in that institute in step S5
Hose cladding material and hose inner layer material are stated according in 1.3:1 injection model, at 230 DEG C of temperature, squeezed out, be pressed into
Type.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811186013.7A CN109320991A (en) | 2018-10-11 | 2018-10-11 | A kind of preparation method of medical infusion antibacterial hose |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811186013.7A CN109320991A (en) | 2018-10-11 | 2018-10-11 | A kind of preparation method of medical infusion antibacterial hose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109320991A true CN109320991A (en) | 2019-02-12 |
Family
ID=65261488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811186013.7A Withdrawn CN109320991A (en) | 2018-10-11 | 2018-10-11 | A kind of preparation method of medical infusion antibacterial hose |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109320991A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109896135A (en) * | 2019-03-07 | 2019-06-18 | 扬州鸿和达塑胶日化有限公司 | A kind of washing product hose and its technological process of production |
| CN116003913A (en) * | 2023-01-31 | 2023-04-25 | 上海琦识医疗科技有限公司 | Precise medical catheter and preparation method thereof |
-
2018
- 2018-10-11 CN CN201811186013.7A patent/CN109320991A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109896135A (en) * | 2019-03-07 | 2019-06-18 | 扬州鸿和达塑胶日化有限公司 | A kind of washing product hose and its technological process of production |
| CN116003913A (en) * | 2023-01-31 | 2023-04-25 | 上海琦识医疗科技有限公司 | Precise medical catheter and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109320991A (en) | A kind of preparation method of medical infusion antibacterial hose | |
| CN107200799A (en) | Metallic ion coordination natural polymer/polyacrylic acid selfreparing gel process for preparing | |
| CN102304257B (en) | Medical PVC material adopted for steam sterilization, and preparation method thereof | |
| CN110079891A (en) | A kind of biodegradable PVA melt spinning resin and its application | |
| CN103483491A (en) | Carbomer and preparation method thereof | |
| CN104356536A (en) | Medical antibacterial hose and preparation method thereof | |
| CN104387693A (en) | Medical plastic composite material and preparation method thereof | |
| CN105566799B (en) | A kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines | |
| CN106977832A (en) | Woven hose environment-friendly type high transparency PVC composition | |
| CN101412793A (en) | Method for modifying acroleic acid super absorbent polymers by using silk | |
| CN106147280A (en) | A kind of fire-resistant PVC of high-strength high temperature-resistant | |
| CN102352078A (en) | Medical polyvinyl chloride (PVC) shading color paste | |
| CN103601850A (en) | Preparation method of super absorbent resin | |
| CN108383945A (en) | A kind of agricultural water-loss reducer and preparation method thereof | |
| CN106496369B (en) | A kind of crosslinking agent and its preparation method and application | |
| CN104629216A (en) | Environmentally friendly matte elastic composite material as well as preparation method and application thereof | |
| CN104072677A (en) | Preparing method of polymer hydrogel with semi-interpenetrating network structure | |
| CN108102406A (en) | It is a kind of can the absorption of anti-bubble TPE infusion tube materials and preparation method thereof | |
| CN105838008A (en) | Nano titanium dioxide modified polyvinyl alcohol membrane | |
| CN105860216A (en) | Inner film of edible salt packaging bag | |
| CN201399898Y (en) | Non-PVC precise filter transfusion-system mandrel-free high-frequency welding device | |
| CN116178861B (en) | High-transparency medical material and preparation method thereof | |
| CN107573534A (en) | A kind of preparation method of the porous-starch with emulsibility | |
| CN108384179A (en) | A kind of composite plastic urn formula septic tank and its preparation process | |
| CN112708279B (en) | Silica gel sealing process of waterproof chain |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190212 |
|
| WW01 | Invention patent application withdrawn after publication |