CN109304854A - Upright polypropylene transfusion flexible bag production technology - Google Patents

Upright polypropylene transfusion flexible bag production technology Download PDF

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Publication number
CN109304854A
CN109304854A CN201811474274.9A CN201811474274A CN109304854A CN 109304854 A CN109304854 A CN 109304854A CN 201811474274 A CN201811474274 A CN 201811474274A CN 109304854 A CN109304854 A CN 109304854A
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China
Prior art keywords
bag
transfusion flexible
flexible bag
pressure
polypropylene transfusion
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CN201811474274.9A
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CN109304854B (en
Inventor
阮传明
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Guangxi Yu Yuan Pharmaceutcal Corp Ltd
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Guangxi Yu Yuan Pharmaceutcal Corp Ltd
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/02Combined blow-moulding and manufacture of the preform or the parison
    • B29C49/06Injection blow-moulding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/42Component parts, details or accessories; Auxiliary operations
    • B29C49/78Measuring, controlling or regulating
    • B29C49/783Measuring, controlling or regulating blowing pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/02Combined blow-moulding and manufacture of the preform or the parison
    • B29C2049/023Combined blow-moulding and manufacture of the preform or the parison using inherent heat of the preform, i.e. 1 step blow moulding

Abstract

The invention belongs to medical infusion bags technical fields, more particularly to upright polypropylene transfusion flexible bag production technology, including following preparation step: 1) installing a bag mold tool on injection molding machine, put into injecting machine material tube, start barrel heating, heating, pp material molten condition have the plastic injection progressive die of molten condition, divide three sections of progress pressure maintainings, become the bag base of solid after cooling, demoulding obtains a bag base;2) after putting bag base into vacuum chamber, then by bag base investment blow moulding machine, heating is passed through compressed air and is blow molded, in blow mold, the longitudinal stretching of drawn bar and laterally blow molding, then through cooling, obtain upright polypropylene transfusion flexible bag.Upright polypropylene transfusion flexible bag production technology through the invention can be improved upright polypropylene transfusion flexible bag yield, reduce rejection rate, improve the light transmittance of upright polypropylene transfusion flexible bag, convenient directly to observe quality of liquid medicine.

Description

Upright polypropylene transfusion flexible bag production technology
Technical field
The invention belongs to medical infusion bags technical fields, and in particular to upright polypropylene transfusion flexible bag production technology.
Background technique
Infusion products develop comparatively fast over the past decade in China, are one of current pharmaceuticals industry primary formulations.A batch treatment With infusion new varieties such as quinolones, children amino acid, Ribavirin, azithromycin, Nimodipine, Isosorbide-5-Nitrae And the kinds such as Chinese traditional medicine transfusion kind Puerarin, Radix Salviae Miltiorrhizae are succeeded in developing in succession and obtain production approval number, wherein most is real Industrialization is showed and has launched;Novel infusion packaging continues to bring out, and plastics package infusion yield accounts for for about 1.5 hundred million bottles (bag) at present The 5% of infusion total growth;The structure of size is continued to optimize, and annual output is more than that 30,000,000 bottles of enterprise has 18 at present, surpasses 100,000,000 bottles Enterprise have 2, preceding 50 production concentration degrees reach 46%;Working condition is greatly improved, 393, whole nation infusion production enterprise There are 246 to obtain GMP certification by transformation in industry, product quality significantly improves.
The structure updating of infusion products is mainly manifested in two aspects: first is that: the upgrading of packaging material: packaging material is to soft modeling Change upgrading: in recent years in big Infused dosages, glass bottle is infused accounting in falling tendency year by year, plastic bottle and soft bag infusion totally rise compared with Fastly;The following infusion products will continue the upgrading from glass bottle to plastic bottle, plastic bottle to soft bag, second is that: the upgrading of product category: product Type upgrades to diversification.China's infusion solution kind and clinical demand and western developed country ratio, there is also biggish gaps. Although China has developed a batch infusion new varieties in recent years, breed structure is also optimized, and therapeutic type infusion is predominantly anti- Raw element, auxotype infusion are mainly glucose, amino acid etc., and kind series needs further to enrich.
Currently, in China's infusion, existing packaging material mainly has glass bottle, plastic bottle, non-PVC-soft-bag and upright flexible bag 4 in the market Kind form.Wherein non-PVC-soft-bag accounting is larger, growth rate is also very fast;And soft bag infusion haves the defects that material and cost is high, As transitional product, sales volume is reduced year by year.And the upright polypropylene transfusion flexible bag newly gone out has safe, practical, warp Ji, the characteristic of environmental protection.The maximum differential of upright polypropylene transfusion flexible bag product and other packaged form infusion products is to be not required to Use exhaust needle open air access, it is entirely avoided secondary pollution caused by contacting in infusion process with air ensure that The safety of clinical treatment and the health of patient.Meanwhile the product overcomes the high disadvantage of non-PVC soft bag transfusion product cost, The country has stronger competitiveness.But the quality and yield of upright polypropylene transfusion flexible bag also need further to mention at present It is high.Therefore, it in order to improve the quality and yield of upright polypropylene transfusion flexible bag, raises labour productivity simultaneously, optimization is upright Formula polypropylene transfusion soft bag production technology is necessary.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of upright polypropylene transfusion flexible bag production technologies, improve straight The quality and yield of vertical polypropylene transfusion soft bag.
To achieve the above object, the present invention adopts the following technical scheme:
Upright polypropylene transfusion flexible bag production technology, including following preparation step:
1) a bag mold tool is installed on injection molding machine, and pharmaceutical grade pp material is put into injecting machine material tube, starting material Cylinder heating, is heated to 180 DEG C -240 DEG C, pp material by it is solid state transformed be molten condition, by the plastic injection of molten condition Progressive die tool, point three sections of progress pressure maintainings: first segment pressure is 50-65kPa, and the dwell time is 0.5~1 second, and second segment pressure is 30- 45kPa, dwell time are 0.5~1 second, and third section pressure is 55-60kPa, and the dwell time is 1~2 second, become solid after cooling Bag base, demoulding, obtain a bag base;
2) after bag base being put to the vacuum chamber 10-20s that vacuum degree is 60-80kPa into, then by bag base investment blow moulding machine, add Heat is passed through compressed air and is blow molded to 120 DEG C~125 DEG C, and in blow mold, the longitudinal stretching and transverse direction of drawn bar are blown Modeling, then through cooling, obtain upright polypropylene transfusion flexible bag.
Preferably, in step 1) of the present invention, point three sections of progresss pressure maintainings: first segment pressure is 60kPa, and the dwell time is 0.5 second, second segment pressure was 40kPa, and the dwell time is 1 second, and third section pressure is 58kPa, and the dwell time is 1.5 seconds.
Preferably, in step 1) of the present invention, 35~40 DEG C of cooling water temperature.
Preferably, in step 2) of the present invention, bag base is put into vacuum chamber 15s that vacuum degree is 70kPa.In blow molding Before, bag base is put into vacuum chamber, the heating temperature in blow moulding machine can be reduced, shortens heating time, while also reducing and adding Heat energy, in addition, passing through the step, additionally it is possible to reduce the rejection rate of upright polypropylene transfusion flexible bag, improve yield rate, fill Divide and utilize raw material, avoids the waste of raw material.
Preferably, in step 2) of the present invention, 123 DEG C are heated to.After vacuum chamber is handled, in blow moulding machine Heating temperature is excessively high or too low, and the yield of product can all be made to reduce, and rejection rate increases, while reducing the matter of transfusion flexible bag Amount, so that light transmittance reduces.
Preferably, in step 2) of the present invention, using temperature at 25-30 DEG C, pressure is that the circulation of 0.4-0.6MPa is cold But water is cooled down.
Compared with prior art, the beneficial effects of the present invention are:
It is handled in production technology of the invention by the segmentation pressure maintaining of high-low-high and by vacuum chamber, reduces blow moulding machine Interior heating temperature, while can be improved upright polypropylene transfusion flexible bag yield, rejection rate is reduced, upright polypropylene is improved The light transmittance of transfusion flexible bag, it is convenient directly to observe quality of liquid medicine.
Specific embodiment
The invention will be further described with reference to embodiments, but the invention is not limited to these embodiments.
Embodiment 1
Upright polypropylene transfusion flexible bag production technology, including following preparation step:
1) a bag mold tool is installed on injection molding machine, and pharmaceutical grade pp material is put into injecting machine material tube, starting material Cylinder heating, is heated to 210 DEG C, pp material by it is solid state transformed be molten condition, the plastic injection progressive die of molten condition is had, Point three sections of progresss pressure maintainings: first segment pressure is 60kPa, and the dwell time is 0.5 second, and second segment pressure is 40kPa, and the dwell time is 1 second, third section pressure was 58kPa, and the dwell time is 1.5 seconds, was the bag for becoming solid in cooling water after cooling at 35 DEG C of temperature Base, demoulding, obtains a bag base;
2) after bag base being put to the vacuum chamber 15s that vacuum degree is 70kPa into, then by bag base investment blow moulding machine, 123 are heated to DEG C, it is passed through compressed air and is blow molded, in blow mold, the longitudinal stretching of drawn bar and laterally blow molding are existed using temperature 25 DEG C, pressure is that the recirculated cooling water of 0.5MPa is cooled down, and obtains upright polypropylene transfusion flexible bag.
Embodiment 2
Upright polypropylene transfusion flexible bag production technology, including following preparation step:
1) a bag mold tool is installed on injection molding machine, and pharmaceutical grade pp material is put into injecting machine material tube, starting material Cylinder heating, is heated to 180 DEG C, pp material by it is solid state transformed be molten condition, the plastic injection progressive die of molten condition is had, Point three sections of progresss pressure maintainings: first segment pressure is 50kPa, and the dwell time is 0.5 second, and second segment pressure is 30kPa, and the dwell time is 1 second, third section pressure was 55kPa, and the dwell time is 2 seconds, was the bag base for becoming solid in cooling water after cooling at 40 DEG C of temperature, Demoulding, obtains a bag base;
2) after bag base being put to the vacuum chamber 20s that vacuum degree is 60kPa into, then by bag base investment blow moulding machine, 120 are heated to DEG C, it is passed through compressed air and is blow molded, in blow mold, the longitudinal stretching of drawn bar and laterally blow molding are existed using temperature 28 DEG C, pressure is that the recirculated cooling water of 0.6MPa is cooled down, and obtains upright polypropylene transfusion flexible bag.
Embodiment 3
Upright polypropylene transfusion flexible bag production technology, including following preparation step:
1) a bag mold tool is installed on injection molding machine, and pharmaceutical grade pp material is put into injecting machine material tube, starting material Cylinder heating, is heated to 240 DEG C, pp material by it is solid state transformed be molten condition, the plastic injection progressive die of molten condition is had, Point three sections of progresss pressure maintainings: first segment pressure is 65kPa, and the dwell time is 1 second, and second segment pressure is 45kPa, and the dwell time is 0.5 second, third section pressure was 60kPa, and the dwell time is 1 second, was the bag for becoming solid in cooling water after cooling at 35 DEG C of temperature Base, demoulding, obtains a bag base;
2) after bag base being put to the vacuum chamber 10s that vacuum degree is 80kPa into, then by bag base investment blow moulding machine, 125 are heated to DEG C, it is passed through compressed air and is blow molded, in blow mold, the longitudinal stretching of drawn bar and laterally blow molding are existed using temperature 30 DEG C, pressure is that the recirculated cooling water of 0.4MPa is cooled down, and obtains upright polypropylene transfusion flexible bag.
Embodiment 4
1) a bag mold tool is installed on injection molding machine, and pharmaceutical grade pp material is put into injecting machine material tube, starting material Cylinder heating, is heated to 210 DEG C, pp material by it is solid state transformed be molten condition, the plastic injection progressive die of molten condition is had, Point three sections of progresss pressure maintainings: first segment pressure is 65kPa, and the dwell time is 1 second, and second segment pressure is 45kPa, and the dwell time is 0.5 second, third section pressure was 60kPa, and the dwell time is 1 second, was the bag for becoming solid in cooling water after cooling at 35 DEG C of temperature Base, demoulding, obtains a bag base;
2) after bag base being put to the vacuum chamber 15s that vacuum degree is 70kPa into, then by bag base investment blow moulding machine, 123 are heated to DEG C, it is passed through compressed air and is blow molded, in blow mold, the longitudinal stretching of drawn bar and laterally blow molding are existed using temperature 25 DEG C, pressure is that the recirculated cooling water of 0.5MPa is cooled down, and obtains upright polypropylene transfusion flexible bag.
Embodiment 5
Upright polypropylene transfusion flexible bag production technology, including following preparation step:
1) a bag mold tool is installed on injection molding machine, and pharmaceutical grade pp material is put into injecting machine material tube, starting material Cylinder heating, is heated to 210 DEG C, pp material by it is solid state transformed be molten condition, the plastic injection progressive die of molten condition is had, Point three sections of progresss pressure maintainings: first segment pressure is 50kPa, and the dwell time is 0.5 second, and second segment pressure is 30kPa, and the dwell time is 1 second, third section pressure was 55kPa, and the dwell time is 2 seconds, was the bag base for becoming solid in cooling water after cooling at 35 DEG C of temperature, Demoulding, obtains a bag base;
2) after bag base being put to the vacuum chamber 15s that vacuum degree is 70kPa into, then by bag base investment blow moulding machine, 123 are heated to DEG C, it is passed through compressed air and is blow molded, in blow mold, the longitudinal stretching of drawn bar and laterally blow molding are existed using temperature 25 DEG C, pressure is that the recirculated cooling water of 0.5MPa is cooled down, and obtains upright polypropylene transfusion flexible bag.
Embodiment 6
Unlike the first embodiment: bag base puts the vacuum chamber 10s that vacuum degree is 80kPa into, remaining step is the same as embodiment 1.
Embodiment 7
Unlike the first embodiment: bag base puts the vacuum chamber 20s that vacuum degree is 60kPa into, remaining step is the same as embodiment 1.
Embodiment 8
Unlike the first embodiment: in the step 2), being heated to 120 DEG C, remaining step is the same as embodiment 1.
Embodiment 9
Unlike the first embodiment: in the step 2), being heated to 125 DEG C, remaining step is the same as embodiment 1.
Comparative example 1
1) a bag mold tool is installed on injection molding machine, and pharmaceutical grade pp material is put into injecting machine material tube, starting material Cylinder heating, is heated to 210 DEG C, pp material by it is solid state transformed be molten condition, the plastic injection progressive die of molten condition is had, It is the bag base for becoming solid in cooling water after cooling at 35 DEG C of temperature in 60kPa pressure maintaining 3s, demoulding obtains a bag base;
Remaining step is the same as embodiment 1.
Comparative example 2
1) a bag mold tool is installed on injection molding machine, and pharmaceutical grade pp material is put into injecting machine material tube, starting material Cylinder heating, is heated to 210 DEG C, pp material by it is solid state transformed be molten condition, the plastic injection progressive die of molten condition is had, Point three sections of progresss pressure maintainings: first segment pressure is 60kPa, and the dwell time is 0.5 second, and second segment pressure is 58kPa, and the dwell time is 1.5 seconds, third section pressure was 40kPa, and the dwell time is 1 second, was the bag for becoming solid in cooling water after cooling at 35 DEG C of temperature Base, demoulding, obtains a bag base;
Remaining step is the same as embodiment 1.
Comparative example 3
1) a bag mold tool is installed on injection molding machine, and pharmaceutical grade pp material is put into injecting machine material tube, starting material Cylinder heating, is heated to 210 DEG C, pp material by it is solid state transformed be molten condition, the plastic injection progressive die of molten condition is had, Point three sections of progresss pressure maintainings: first segment pressure is 40kPa, and the dwell time is 1 second, and second segment pressure is 58kPa, and the dwell time is 1.5 seconds, third section pressure was 60kPa, and the dwell time is 0.5 second, was to become solid in cooling water after cooling at 35 DEG C of temperature Bag base, demoulding obtain a bag base;
Remaining step is the same as embodiment 1.
Comparative example 4
1) a bag mold tool is installed on injection molding machine, and pharmaceutical grade pp material is put into injecting machine material tube, starting material Cylinder heating, is heated to 210 DEG C, pp material by it is solid state transformed be molten condition, the plastic injection progressive die of molten condition is had, Point three sections of progresss pressure maintainings: first segment pressure is 60kPa, and the dwell time is 0.5 second, and second segment pressure is 40kPa, and the dwell time is 1 second, be the bag base for becoming solid in cooling water after cooling at 35 DEG C of temperature, and demoulding obtains a bag base;
Remaining step is the same as embodiment 1.
Comparative example 5
Unlike the first embodiment: bag base puts the vacuum chamber 5s that vacuum degree is 90kPa into, remaining step is the same as embodiment 1.
Comparative example 6
Unlike the first embodiment: bag base puts the vacuum chamber 30s that vacuum degree is 50kPa into, remaining step is the same as embodiment 1.
Comparative example 7
Unlike the first embodiment: in the step 2), being heated to 118 DEG C, remaining step is the same as embodiment 1.
Comparative example 8
Unlike the first embodiment: in the step 2), being heated to 130 DEG C, remaining step is the same as embodiment 1.
Test example 1: the different production technology of the present invention is to upright polypropylene transfusion flexible bag yield, rejection rate and light transmittance Influence
It is tested in Qiezhou pharmaceutical factory, meets YBB00142002-2015 " drug packing material and drug phase in product Compatibility test guideline " under conditions of, the yield and rejection rate of one week (production time is identical) of each test example are counted, is remembered Yield and rejection rate are recorded, the rejection rate is the rejection rate that corresponding yield generates.
The smooth position of infusion bag is taken, the slice of 5 ㎝ of 0.9 ㎝ × 4 is cut into, is put into absorption along incident light vertical direction respectively Chi Zhong, topped up with water, and using water as blank, according to spectrophotometry (Pharmacopoeia of People's Republic of China two annex IV of version in 2010 A), light transmittance is measured at 450nm, respectively takes 10 bags, results are averaged.
Influence of the different pressure holding steps of table 1 to upright polypropylene transfusion flexible bag yield, rejection rate and light transmittance
Different process Yield/(ten thousand bags/week) Rejection rate/% Average transmittance/%
Embodiment 1 3.35 0 95.1
Embodiment 4 3.23 0 93.2
Embodiment 5 3.14 0 94.9
Comparative example 1 2.21 0.12 73.6
Comparative example 2 2.60 0.18 79.5
Comparative example 3 2.41 0.23 76.1
Comparative example 4 2.46 0.15 75.8
The different influences being vacuum-treated to upright polypropylene transfusion flexible bag yield, rejection rate and light transmittance of table 2
Different process Yield/(ten thousand bags/week) Rejection rate/% Average transmittance/%
Embodiment 1 3.35 0 95.1
Embodiment 6 3.15 0 94.3
Embodiment 7 3.23 0 94.8
Comparative example 5 2.31 0.09 75.7
Comparative example 6 2.40 0.16 78.2
Shadow of the different heating temperature to upright polypropylene transfusion flexible bag yield, rejection rate and light transmittance in 3 blow moulding machine of table It rings
Different process Yield/(ten thousand bags/week) Rejection rate/% Average transmittance/%
Embodiment 1 3.35 0 95.1
Embodiment 8 3.21 0 94.3
Embodiment 9 3.25 0 94.5
Comparative example 7 2.18 0.35 75.3
Comparative example 8 2.24 0.28 76.4

Claims (6)

1. upright polypropylene transfusion flexible bag production technology, which is characterized in that including following preparation step:
1) a bag mold tool is installed on injection molding machine, pharmaceutical grade pp material is put into injecting machine material tube, and starting barrel adds Heat, is heated to 180 DEG C -240 DEG C, pp material by it is solid state transformed be molten condition, by the plastic injection progressive die of molten condition Tool, point three sections of progress pressure maintainings: first segment pressure is 50-65kPa, and the dwell time is 0.5~1 second, and second segment pressure is 30- 45kPa, dwell time are 0.5~1 second, and third section pressure is 55-60kPa, and the dwell time is 1~2 second, become solid after cooling Bag base, demoulding, obtain a bag base;
2) it after bag base being put to the vacuum chamber 10-20s that vacuum degree is 60-80kPa into, then by bag base investment blow moulding machine, is heated to It 120 DEG C~125 DEG C, is passed through compressed air and is blow molded, in blow mold, the longitudinal stretching of drawn bar and laterally blow molding, Again through cooling, upright polypropylene transfusion flexible bag is obtained.
2. upright polypropylene transfusion flexible bag production technology according to claim 1, it is characterised in that: the step 1) In, point three sections of progresss pressure maintainings: first segment pressure is 60kPa, and the dwell time is 0.5 second, and second segment pressure is 40kPa, when pressure maintaining Between be 1 second, third section pressure be 58kPa, the dwell time be 1.5 seconds.
3. upright polypropylene transfusion flexible bag production technology according to claim 1, it is characterised in that: the step 1) In, 35~40 DEG C of cooling water temperature.
4. upright polypropylene transfusion flexible bag production technology according to claim 1, it is characterised in that: the step 2) In, put bag base into vacuum chamber 15s that vacuum degree is 70kPa.
5. upright polypropylene transfusion flexible bag production technology according to claim 1, it is characterised in that: the step 2) In, it is heated to 123 DEG C.
6. upright polypropylene transfusion flexible bag production technology according to claim 1, it is characterised in that: the step 2) In, using temperature at 25-30 DEG C, pressure is that the recirculated cooling water of 0.4-0.6MPa is cooled down.
CN201811474274.9A 2018-12-04 2018-12-04 Production process of vertical polypropylene transfusion soft bag Active CN109304854B (en)

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Publication number Priority date Publication date Assignee Title
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CN104419065A (en) * 2013-09-03 2015-03-18 辽宁九洲龙跃药业有限公司 Polypropylene-blended soft infusion bag and preparation method thereof
JP2016159589A (en) * 2015-03-04 2016-09-05 ファナック株式会社 Pressure control device for injection molding machine

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Publication number Priority date Publication date Assignee Title
CN101716124A (en) * 2009-12-17 2010-06-02 蚌埠丰原涂山制药有限公司 Jointless transfusion soft bag and preparation method thereof
CN101786335A (en) * 2010-01-26 2010-07-28 新疆华世丹药业股份有限公司 Upright flexible bag infusion bottle preparation method
CN104419065A (en) * 2013-09-03 2015-03-18 辽宁九洲龙跃药业有限公司 Polypropylene-blended soft infusion bag and preparation method thereof
JP2016159589A (en) * 2015-03-04 2016-09-05 ファナック株式会社 Pressure control device for injection molding machine

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