CN109303832A - A kind of Chinese medicine and preparation method thereof for treating ankylosing spondylitis - Google Patents

Abstract

The present invention relates to the field of Chinese medicines, in particular to a kind of Chinese medicine and preparation method thereof for treating ankylosing spondylitis.The drug is made of by weight following raw material: 5-15 parts of ramulus cinnamomi, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of Radix Paeoniae Alba, 10-15 parts of monkshood, 10-20 parts of rhizoma cibotii, 15-25 parts of radix dipsaci, 10-15 parts of Chinese violet, 10-15 parts of Radix Angelicae Sinensis, 10-15 parts of rice galingale herb, 10-15 parts of the root bark of Chinese wolf-berry, 10-15 parts of cortex acanthopanacis, 10-15 parts of lopseed；For the present invention according to traditional Chinese medical theory, preparation method is simple, and bulk pharmaceutical chemicals are carried out charcoal burning, so that drug effect is gentle, inducing diaphoresis is sensible, does not stimulate blood vessel, penetration is strong, opens channels and collaterals, saturating muscles and bones, safety is good, it is without side-effects, it can be relieved the pain of patient, promote microcirculation, short treating period has extraordinary therapeutic effect to ankylosing spondylitis.

Description

A kind of Chinese medicine and preparation method thereof for treating ankylosing spondylitis

Technical field

The present invention relates to the field of Chinese medicines, in particular to a kind of Chinese medicine and preparation method thereof for treating ankylosing spondylitis.

Background technique

Ankylosing spondylitis is to cause tetanic and fibrosis disease with articulatio sacroiliaca and backbone attachment point inflammation.It is common In 16~30 years old young people, male was common.This disease insidious onset, makes slow progress, and constitutional symptom is lighter.Early stage often have back pain and It is stiff from morning, mitigate after activity, and can be with the symptoms such as low-heat, out of strength, appetite stimulator, syntexis.Pain is intermittence when beginning, Development is duration after several years several months, and later inflammatory pain disappears, and backbone is from bottom to top partly or entirely tetanic, is occurred bow-backed abnormal Shape.Female patients periarticular is in progress slower, deformity of spine is lighter by invading more typically.

The clinical manifestation of ankylosing spondylitis are as follows:

(1) sacro-iliitis: about 90% ankylosing spondylitis patient shows as sacro-iliitis at first.Later uplink is developed to neck Vertebra shows as the pain in the loins of recurrent exerbation, lumbosacral region stiff sense, and intermittent or two sides are alternately present pain in the loins and two sides pain of buttock, Radiation to thigh, no positive sign, straight lift leg negative.But directly pressing or stretching, extension articulatio sacroiliaca can cause pain, So unlike sciatica.Some patients have abnormal change without sacro-iliitis symptom, only x-ray inspection discovery.About 3% is tetanic Property rachitis cervical vertebra be involved earliest, later downward progression to lumbosacral region, 7% ankylosing spondylitis be a few tool spinal column segments be involved simultaneously.

(2) lumbal vertebra: lumbar is by for a long time, and majority is shown as before lower back and waist limitation of activity.Waist is anteflexion, button Cobalt, lateral bending and rotation can be limited.Physical examination can find that lumbar vertebrae ridge is dashed forward tenderness, muscle cramp by lumbar vertebrae；Later period can have psoas muscle atrophy.

(3) thoracic vertebrae lesion: for thoracic vertebrae by backache, shirtfront and pleurobranch pain for a long time, is shown as, most commonly hunchback is lopsided.Such as rib By for a long time, being then in band shape pectoralgia, thoracic expansion is limited for vertebral articulations, breastbone shank body joint, articulatio sternoclavicularis and articulationes interchondrales, Pectoralgia aggravates when air-breathing cough or sneezing.Serious person's thorax is maintained at institute's state of exhaling, and thoracic expansion reduces by 50% compared with normal person More than, therefore can only be assisted by abdominal respiration.Since splanchnocoel capacity reduces, cardio-pulmonary function and digestive functional disturbance are caused.

(4) cervical spondylosis: a few patients first appear as cervical vertebra inflammation, first there is ceruical uertebra part pain, along neck to head arm Radiation.Spasm when musculi colli starts, later atrophy, lesion growth can be developed to neck thoracic kyphosis deformity.Head movement is obvious It is limited, it is often fixed on anteflexion position, cannot be faced upward, lateral bending or rotation.Serious person is only capable of seeing the fritter ground in front of oneself toe, Cannot come back head-up.

(5) periarticular lesion: about half ankylosing spondylitis patient has of short duration acute peripheral arthritis, and about 25% has Permanent periarticular damage.Large joint is generally mostly occurred in, lower limb are more than upper limb.Someone's statistics, periarticular involvement rate, hip It is 40% with shoulder, knee 15,5, ankle 10% seldom involves hand enough with wrist each 5%.Report 80 ankylosing spondylitis, hip joint involvement Rate is sign (100%)；Flexion contracture (38%), muscular atrophy (25%), arthrocleisis (37%) occurs for limitation of activity (64%), is The reason that mainly disables of ankylosing spondylitis patient；Hip symptom appear in after the onset of in 5 years person account for 94%, prompt tatanic ridge As do not involved hip joint, then a possibility that involvement later, is little within the morbidity of column inflammation head 5 years.

In addition, pubic symphysis can also be involved, pelvis upper limb, ischial tuberosity, femoral greater trochanter and heel portion can have inflammation of bone Shape shows as local soft tissue in early days and swells, bitterly, and advanced stage has bone coarse.General periarticular inflammation can occur before rachitis After or, local symptom is not easy to distinguish with rheumatoid arthritis, but it is less to leave lopsided person.

Currently, treatment ankylosing spondylitis needs long-term administration based on controlling disease progression, alleviate symptom.Doctor trained in Western medicine Duo Cai With anti-inflammatory and immunosuppressive therapy, key agents are non-steroidal anti-inflammatory drugs, sulfasalazine, methotrexate (MTX), glucocorticoid etc., The clinical manifestation of patient can be improved rapidly, but if take for a long time can cause gastrointestinal tract, hematology and other systematic complications with And the adverse reactions such as lesions of liver and kidney, patient compliance are poor.Although biological agent can alleviate the disease of painful swelling of joints to a certain extent Shape, but its erious adverse reaction, expensive, the course for the treatment of is long, general patient is difficult to receive.

Chinese medicine thinks ankylosing spondylitis and cold-dampness numbness, and the heat toxin stasis of blood is stagnant, phlegm-blood stasis and hand over resistance, and kidney qi virtual loss is related.It is basic The interpretation of the cause, onset and process of an illness is that the insufficiency of the kidney yang, governor vessel be hollow, cold-evil's invasion, is detained muscles and bones and causes.Chinese traditional treatment ankylosing spondylitis alleviate symptom, Delay disease progression, improvement patients ' life quality etc. curative for effect, Small side effects, safety good.The present invention is handed down from one's ancestors secret There is preferable effect in side to alleviating and treating ankylosing spondylitis.

Summary of the invention

The present invention aiming at the shortcomings in the prior art, provides a kind of Chinese medicine for treating ankylosing spondylitis and its preparation side Method.

The present invention is achieved through the following technical solutions:

A kind of Chinese medicine for treating ankylosing spondylitis, it is characterized in that: being made of by weight following raw material: 5-15 parts of ramulus cinnamomi, white 10-15 parts of art, 10-15 parts of Radix Paeoniae Alba, 10-15 parts of monkshood, 10-20 parts of rhizoma cibotii, 15-25 parts of radix dipsaci, 10-15 parts of Chinese violet, Radix Angelicae Sinensis 10- 15 parts, 10-15 parts of rice galingale herb, 10-15 parts of the root bark of Chinese wolf-berry, 10-15 parts of cortex acanthopanacis, 10-15 parts of lopseed.

Preferably, the Chinese medicine of the treatment ankylosing spondylitis, is made of: 10 parts of ramulus cinnamomi, white by weight following raw material 13 parts of art, 13 parts of Radix Paeoniae Alba, 12 parts of monkshood, 15 parts of rhizoma cibotii, 20 parts of radix dipsaci, 12 parts of Chinese violet, 12 parts of Radix Angelicae Sinensis, 12 parts of rice galingale herb, ground bone 12 parts of skin, 12 parts of cortex acanthopanacis, 12 parts of lopseed.

The preparation method of the Chinese medicine of the treatment ankylosing spondylitis, includes the following steps:

Above-mentioned each raw material is put into pot and is stir-fried, is fried to there is burning, is then pressed into powder, is fitted into bag after mixing, is made At medicine bag.

Application method: being externally applied to affected part for medicine bag, such as sacrum hypozygal, knee joint, ankle-joint, thoracic vertebrae 1-3 joint, 24 Medicine bag is taken down after hour, interval is after 4 days, then medicine dressing change bag applies 24 hours in affected part, is repeated in circulation, and 3 weeks as a treatment course, and one treats Journey can fully recover, and fully recover after two course for the treatment of of weight patient.

Each bulk pharmaceutical chemicals medicinal function is as follows:

Ramulus cinnamomi: acrid, sweet, warm enter lung, the heart, bladder meridian, sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi.

Rhizoma Atractylodis Macrocephalae: bitter, it is sweet, it is warm-natured.Returns spleen, stomach meridian.Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention.For spleen eating less, Abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, threatened abortion.Rhizoma Atractylodis Macrocephalae invigorating the spleen, stomach function regulating, miscarriage prevention.For spleen eating less, diarrhea is just It is half congealed, threatened abortion.

Radix Paeoniae Alba: calming the liver and relieving pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For headache and dizziness, hypochondriac pain, abdominal pain, four limbs contraction pain, the deficiency of blood It is sallow, irregular menstruation, spontaneous perspiration, night sweat.

Monkshood: controlling irregular menstruation, controls urine gonorrhoea, controls urine void and closes, and controls ten finger pain.

Rhizoma cibotii: it is bitter, sweet, it is warm-natured;Return liver and kidney channel;Matter heavily fortified point row dissipates, and drops and can rise;With strong waist and knee, wind-damp dispelling reinforces the kidney The effect of gas;Lumbago due to the kidney deficiency ridge is strong, and sufficient knee is weak and feeble, rheumatic arthralgia, the enuresis, frequent micturition, spermatorrhea, leukorrhea

Radix dipsaci: nourishing liver and kidney, continuous muscles and bones adjust blood vessels.Control aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia and metrostaxis, leukorrhagia, spermatorrhea, bruise damage Wound, metal-inflicted wound, anal fistula, ulcer sore swells.

Chinese violet: cold in nature, bitter, mild toxicity；Enter the heart, the spleen channel, it is clearing heat and detoxicating.It is irritated to control warm disease high fever, influenza, infectiousness liver Inflammation, ephritis, scrofula, parotitis, furunculosis and other pyogenic infections.

Radix Angelicae Sinensis: it is sweet, pungent, warm, return liver, the heart, the spleen channel.It enriches blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturizing dryness and lubricating intestine.The main all cards of the deficiency of blood；Month Through uncomfortable；Menostasis；Dysmenorrhea；Abdominal mass knot is poly-；Metrorrhagia and metrostaxis；Asthenia cold abdominalgia；Flaccidity syndrome and arthralgia syndrome；Numbness；Intestines are dry and shit is difficult；Weight after dysentery with bloody stool；Ulcer Sore；Injury from falling down.

Rice galingale herb: mild-natured, acrid flavour, it is nontoxic, control rheumatalgia, the left right paralysis of paralysis.

The root bark of Chinese wolf-berry: it is cold in nature, it is sweet in flavor；Enter lung, liver and kidney channel.Heat-clearing, cool blood.Consumptive disease hectic fever night sweat is controlled, lung heat cough and asthma is spitted blood, Bleeding from five sense organs or subcutaneous tissue, blood strangury are quenched one's thirst, hypertension, carbuncle swells, malignant sore.

Cortex acanthopanacis: acrid flavour, hardship, it is warm-natured；Liver and kidney channel.There is wind-damp dispelling, tonify the liver and kidney, strengthens muscles and bones, the work of inducing diuresis for removing edema With；For Bi condition, muscles and bones impotence, children's retardation of walking, asthenia, oedema, tinea pedis.

Lopseed: sweet, acrid, warm；Enter lung, liver two passes through.Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, promoting blood circulation and stopping pain, solution poison rash.

For the present invention according to traditional Chinese medical theory, preparation method is simple, and bulk pharmaceutical chemicals are carried out charcoal burning, so that drug effect is gentle, inducing diaphoresis It is sensible, blood vessel is not stimulated, penetration is strong, opens channels and collaterals, and saturating muscles and bones, safety is good, and it is without side-effects, the pain of patient can be relieved Bitterly, promote microcirculation, short treating period has extraordinary therapeutic effect to ankylosing spondylitis.

Specific embodiment

One, the present invention is further elaborated combined with specific embodiments below, it should be appreciated that, following the description is only In order to explain the present invention, its content is not defined.

Embodiment one:

Weigh ramulus cinnamomi 5g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 10g, monkshood 10g, rhizoma cibotii 10g, radix dipsaci 20g, 12g parts of Chinese violet, 10g parts of Radix Angelicae Sinensis, three Stupefied grass 10g, root bark of Chinese wolf-berry 10g, cortex acanthopanacis 10g, lopseed 10g are put into pot and stir-fry, and fry to there is burning, are then pressed into Powder is fitted into bag after mixing, and medicine bag is made, and medicine bag is externally applied to affected part, as sacrum hypozygal, knee joint, ankle close Section, thoracic vertebrae 1-3 joint take down medicine bag after 24 hours, interval is after 4 days, then medicine dressing change bag applies 24 hours in affected part, is repeated in Circulation, 3 weeks as a treatment course.

Embodiment two:

Weigh ramulus cinnamomi 7g, Rhizoma Atractylodis Macrocephalae 13g, Radix Paeoniae Alba 12g, monkshood 11g, rhizoma cibotii 14g, radix dipsaci 17g, 11g parts of Chinese violet, 12g parts of Radix Angelicae Sinensis, three Stupefied grass 13g, root bark of Chinese wolf-berry 14g, cortex acanthopanacis 13g, lopseed 14g are put into pot and stir-fry, and fry to there is burning, are then pressed into Powder is fitted into bag after mixing, and medicine bag is made, and medicine bag is externally applied to affected part, as sacrum hypozygal, knee joint, ankle close Section, thoracic vertebrae 1-3 joint take down medicine bag after 24 hours, interval is after 4 days, then medicine dressing change bag applies 24 hours in affected part, is repeated in Circulation, 3 weeks as a treatment course.

Embodiment three:

Weigh ramulus cinnamomi 10g, 13 g of Rhizoma Atractylodis Macrocephalae, 13 g of Radix Paeoniae Alba, 12 g of monkshood, 15 g of rhizoma cibotii, 20 g of radix dipsaci, 12 g of Chinese violet, Radix Angelicae Sinensis 12 G, 12 g of rice galingale herb, 12 g of the root bark of Chinese wolf-berry, 12 g of cortex acanthopanacis, 12 g of lopseed are put into pot and stir-fry, and fry to there is burning, then Be pressed into powder, be fitted into bag after mixing, medicine bag is made, medicine bag is externally applied to affected part, as sacrum hypozygal, knee joint, Ankle-joint, thoracic vertebrae 1-3 joint, take down medicine bag after 24 hours, interval is after 4 days, then medicine dressing change bag applies 24 hours in affected part, successively Repetitive cycling, 3 weeks as a treatment course.

Example IV:

Weigh ramulus cinnamomi 12g, 14 g of Rhizoma Atractylodis Macrocephalae, 15 g of Radix Paeoniae Alba, 10 g of monkshood, 17 g of rhizoma cibotii, 22 g of radix dipsaci, 15 g of Chinese violet, Radix Angelicae Sinensis 15 G, rice galingale herb 13 g, root bark of Chinese wolf-berry 15g, 13 g of cortex acanthopanacis, 14 g of lopseed are put into pot and stir-fry, and fry to there is burning, then Be pressed into powder, be fitted into bag after mixing, medicine bag is made, medicine bag is externally applied to affected part, as sacrum hypozygal, knee joint, Ankle-joint, thoracic vertebrae 1-3 joint, take down medicine bag after 24 hours, interval is after 4 days, then medicine dressing change bag applies 24 hours in affected part, successively Repetitive cycling, 3 weeks as a treatment course.

Embodiment five:

Weigh ramulus cinnamomi 15g, 15 g of Rhizoma Atractylodis Macrocephalae, 15 g of Radix Paeoniae Alba, 15 g of monkshood, 14 g of rhizoma cibotii, 25 g of radix dipsaci, 15 g of Chinese violet, Radix Angelicae Sinensis 14 G, 15 g of rice galingale herb, 14 g of the root bark of Chinese wolf-berry, 15 g of cortex acanthopanacis, 15 g of lopseed are put into pot and stir-fry, and fry to there is burning, then Be pressed into powder, be fitted into bag after mixing, medicine bag is made, medicine bag is externally applied to affected part, as sacrum hypozygal, knee joint, Ankle-joint, thoracic vertebrae 1-3 joint, take down medicine bag after 24 hours, interval is after 4 days, then medicine dressing change bag applies 24 hours in affected part, successively Repetitive cycling, 3 weeks as a treatment course.

Two, the clinical observation on the therapeutic effect of drug of the present invention

1, general information

For 376 patients with ankylosing spondylitis that selection inventor treated so far from 2015.

Treatment method

The made medicine bag of embodiment 3 is selected to treat patient, dressing is applied again after once applying 24 hours, 4 days, is recycled 30 days with this It is as a treatment course.

Treat curative effect determinate standard

Cure: symptom disappears, and activity is freely；

Effective: symptom is relieved, and can participate in daily routines；

Effective: symptom is eased, and life can take care of oneself, and movable function is restored；

Invalid: symptom is without improvement or aggravation.

Treatment results:

Above-mentioned patient, healing 314,83.5%；Effective 35,9.3%；Effective 23,6.1%；Total effective rate 98.9,；Invalid 4 Example.

5-15 parts of ramulus cinnamomi, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of Radix Paeoniae Alba, 10-15 parts of monkshood, 10-20 parts of rhizoma cibotii, radix dipsaci 15-25 Part, 10-15 parts of Chinese violet, 10-15 parts of Radix Angelicae Sinensis, 10-15 parts of rice galingale herb, 10-15 parts of the root bark of Chinese wolf-berry, 10-15 parts of cortex acanthopanacis, lopseed 10-15 parts

Inventor optimizes summary according to traditional Chinese medical theory, according to many years Couple herbs, and it is simple to provide a kind of preparation method, Only bulk pharmaceutical chemicals need to be subjected to charcoal burning, so that drug effect is gentle, inducing diaphoresis is sensible, does not stimulate blood vessel, and penetration is strong, open channels and collaterals, saturating muscles and bones, Safety is good, without side-effects, can be relieved the pain of patient, promotes microcirculation, and short treating period has very ankylosing spondylitis Good therapeutic effect.

Claims (3)

1. a kind of Chinese medicine for treating ankylosing spondylitis, it is characterized in that: being made of by weight following raw material: 5-15 parts of ramulus cinnamomi, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of Radix Paeoniae Alba, 10-15 parts of monkshood, 10-20 parts of rhizoma cibotii, 15-25 parts of radix dipsaci, 10-15 parts of Chinese violet, Radix Angelicae Sinensis 10-15 parts, 10-15 parts of rice galingale herb, 10-15 parts of the root bark of Chinese wolf-berry, 10-15 parts of cortex acanthopanacis, 10-15 parts of lopseed.

2. the Chinese medicine for the treatment of ankylosing spondylitis according to claim 1, it is characterized in that: by following raw material group by weight At: 10 parts of ramulus cinnamomi, 13 parts of Rhizoma Atractylodis Macrocephalae, 13 parts of Radix Paeoniae Alba, 12 parts of monkshood, 15 parts of rhizoma cibotii, 20 parts of radix dipsaci, 12 parts of Chinese violet, 12 parts of Radix Angelicae Sinensis, three Stupefied careless 12 parts, 12 parts of the root bark of Chinese wolf-berry, 12 parts of cortex acanthopanacis, 12 parts of lopseed.

3. the preparation method of the Chinese medicine for the treatment of ankylosing spondylitis according to claim 1 or 2, it is characterized in that: including such as Lower step:

Above-mentioned each raw material is put into pot and is stir-fried, is fried to there is burning, is then pressed into powder, is fitted into bag after mixing, is made At medicine bag.