CN104840599A

CN104840599A - Medicine for treating ankylosing spondylitis

Info

Publication number: CN104840599A
Application number: CN201510286495.3A
Authority: CN
Inventors: 李小敬
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-05-30
Filing date: 2015-05-30
Publication date: 2015-08-19
Anticipated expiration: 2035-05-30
Also published as: CN104840599B

Abstract

The invention relates to a medicine for treating ankylosing spondylitis. The medicine mainly comprises medicines for oral administration and medicines for external use, wherein the medicines for oral administration include 15g of Chinese dodder seed, 15g of fried himalayan teasel root, 10g of fried eucommia bark, 10g of prepared rhizome of adhesive rehmannia, 10g of common macrocarpium fruit, 15g of east Asian tree fern rhizome, 15g of Chinese taxillus twig, 15g of medicinal cyathula root, 10g of malaytea scurfpea fruit, 15g of cassia twig, 8g of glossy privet fruit, 8g of yerbadetajo herb, 15g of Chinese angelica, 15g of peach seed, 30g of white paeony root and 6g of liquorice root; one dose is taken each day and is decocted in water; the medicines for external use include 15g of incised notopterygium, 15g of cassia twig, 15g of stem of sargentgloryvine, 15g of common clubmoss herb, 15g of garden balsam stem, 8g of sappan wood, 10g of Chinese starjasmine stem and 30g of coix seed; patients lie supine on a fumigating bed, and the medicines for external use are added to water to be decocted for fumigating the patients. The medicine combines the interior and the exterior and treats both symptoms and root causes when being used for treating ankylosing spondylitis, and has obvious efficiency especially when being used for treating ankylosing spondylitis caused by deficiency of the liver and kidneys.

Description

A kind of medicine for the treatment of ankylosing spondylitis

Technical field

The present invention relates to technical field of Chinese medicines, specifically a kind of medicine for the treatment of ankylosing spondylitis.

Background technology

Ankylosing spondylitis is clinical common chronic inflammation disease, mainly to invade spinal column apophysis, sacroiliac joint, the other soft tissue of spinal column and joint, periphery for feature, its incidence of occult, patient engenders that lower back or sacroiliac have an intense pain more, alleviate after activity, the sustainable several months, wrong treatment or mistake are controlled and can be caused deformity of spine and tetanic pathological changes, have a strong impact on the quality of life of patient.Modern medical therapy, based on Drug therapys such as non-steroid antiinflammatory drugs, is intended to relief of symptoms, symptom management, prevents joint deformity.But the untoward reaction that for a long time existence of use is certain, especially gastrointestinal upset serious symptom is heavy then cause ulcerative hemorrhage, perforation, marrow suppression, abnormal liver function etc. ^[1].Comparatively speaking, Enema compress opinion control and can learn from other's strong points to offset one's weaknesses, have rapid-action, untoward reaction is few, ask advantage and characteristics such as originally digging up the roots.

Summary of the invention

The object of the present invention is to provide a kind of medicine for the treatment of ankylosing spondylitis.Chinese medicine preparation of the present invention adopts for oral administration, stifling associating to treat patients with ankylosing spondylitis, effectively solves the impact of patient articular's pain, inflammatory factor.

Technical scheme of the present invention is: a kind of medicine for the treatment of ankylosing spondylitis, mainly comprises for oral administration, external two groups of medicines, wherein oral medicine composition: Semen Cuscutae 15g, fry Radix Dipsaci 15g, Cortex Eucommiae (parched) 10g, Radix Rehmanniae Preparata 10g, Fructus Corni 10g, Rhizoma Cibotii 15g, Herba Taxilli 15g, Radix Cyathulae 15g, Fructus Psoraleae 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 8g, Herba Ecliptae 8g, Radix Angelicae Sinensis 15g, Semen Persicae 15g, Radix Paeoniae Alba 30g, Radix Glycyrrhizae 6g.Every day 1 dose, be decocted in water for oral dose.External used medicine forms: Rhizoma Et Radix Notopterygii 15g, Ramulus Cinnamomi 15g, Caulis Sargentodoxae 15g, Herba Lycopodii 15g, Herba speranskiae tuberculatae 15g, Lignum Sappan 8g, Caulis Trachelospermi 10g, Semen Coicis 30g.Patient lies supine is on steaming bed, and get in top loading gauze medicated bag and put into full-automatic stifling dipping instrument, add water middle decoction, and by affected part just to stifling window, temperature keeps about 40 DEG C, every day 1 time, at every turn stifling half an hour.During treatment, for oral administration, stifling same use 1 month is 1 course for the treatment of, and two groups use 3 months all continuously.

Ankylosing spondylitis is a kind of chronic inflammatory disease rheumatic disease, belongs to Chinese medicine " numbness is sick " category, has again the title of " rheumatism involving the bone ", " severe hunch-back ", " ring wind ".Patient clinical is chief complaint mainly with waist sacrum back pain, arthralgia, joint joint stuffiness etc., thus joint pain alleviation, function of joint improvement be the primary aspect of clinical appraisal curative effect.Modern medicine study is thought, ankylosing spondylitis is the chronic inflammation disease that one kind of multiple factors participate in jointly, and definite pathogenesis is still indefinite, but closely related with factors such as heredity, Non-adhesion inhibition index, immunity, bacteriological infection.In recent years, the biological characteristics of inflammatory cytokine, its role and the relation between its pathogenesis and disease activity in the inflammatory process of autoimmune disease become the important target spot of clinical concern ^[5].If TNF-α is one of cytokine produced the earliest in inflammatory process, body inflammatory reaction can cause its level in local joint and serum to raise, there is multiple inflammatory and immune response activity, the bone destruction in joint and the inflammatory damage of surrounding tissue can be participated in by approach such as inducible factor activation.IL-6 is the high expressing cell factor before a kind of fibrosis, falls ill closely related with inflammation, in recent years with its medicine being targeting to disease incidence mechanism illustrate and clinical treatment has most important theories meaning and using value.In treatment, combination of Chinese and Western medicine opinion tool has the advantage for the treatment of both the principal and secondary aspects of a disease, rapid-action, few side effects.The author's clinical findings patient is many with deficiency of the liver and kindey card, say in conjunction with " Plain Questions the most pure virginity will be discussed greatly " " sun in spring, cold multiple in more than, then lumbosacral pain, joint stuffiness, pain in stock shin foot knee joint " visible deficiency of both the liver and kidney for its morbidity originally.The traditional Chinese medical science has " waist is house of kidney ", " the kidney generating marrow and dominating bone ", " the main muscle of liver storing blood " theory, patient Duo Yin natural endowment is not enough, ferritic is weak, in addition take good care of oneself the day after tomorrow improper, cause body asthenia of essence and blood, causing bone becomes homeless foster, and liver body loses supports, so grain cervical carcinoma with cachexia, muscles and bones is delayed weak, and wind-cold damp pathogen is taken advantage of a weak point morbidity.Therefore the strong muscle of palpus kidney tonifying, expelling wind and removing dampness, the promoting blood circulation to remove obstruction in the collateral controlled.In conjunction with its pathogenic characteristic, the author selects external treatment in the traditional Chinese medical science to share and controls it.Chinese medicine for oral administration is authors'several years Empirical formula, focuses on kidney-boosting tonic.In side, Semen Cuscutae, stir-fry Radix Dipsaci, Cortex Eucommiae (parched) focus on kidney tonifying gas, have the merit of the strong muscle of kidney tonifying; Radix Rehmanniae Preparata, Fructus Corni, Fructus Ligustri Lucidi, Herba Ecliptae merit are filling up kidney essense, with bone marrow of supplementing nutrition; Rhizoma Cibotii is longer than the strong ridge of strong bone, the good medicine that main back is strong, wind is empty; Herba Taxilli is liver and kidney tonifying, dispel the wind, the good medicine of bone and muscle strengthening; Radix Cyathulae merit is at invigorating the liver and kidney, promoting blood circulation to restore menstrual flow, and invigorating middle warmer has row; Fructus Psoraleae focuses on the kidney warming sun, with Ramulus Cinnamomi match can expelling wind and removing dampness, nourishing kidney tonifying YANG, warming yang for activating qi-flowing; Chinese Angelica blood replonishing is invigorated blood circulation; Semen Persicae is longer than promoting blood circulation and breaking stagnation pain relieving; Radix Paeoniae Alba liver nourishing easing the affected liver, with Radix Glycyrrhizae compatibility relieving spasm to stop pain.Multiple medicines compatibility, to mend, be auxiliary to lead to, invigorating middle warmer has row, plays the effect of the strong muscle of kidney tonifying, promoting blood circulation and stopping pain altogether.In addition, herbal fumigation is the warm stimulation affected part skin opening of the pores utilizing medicine as external treatment, and drug effect is gone directly disease institute, has good absorbing, acts on the advantages such as direct, rapid-action.Moreover, medicament fumigating is beneficial to and promotes local affected part blood circulation, with easing joint movement, alleviates arthralgia, have " by table thoroughly in ", " inner disease outer treat ", " antiperspirant and do not hinder battalion defend " feature.Fumigation and wash method focuses on easing joint movement, promoting blood circulation to remove obstruction in the collateral, and medicine is based on nature and flavor bitter cold, and notopterygium wind dispelling dehumidifies, removing obstruction in the collateral to relieve pain; , there is the effect of supporing yang cold expelling, promoting the circulation of QI to relieve pain in Ramulus Cinnamomi energy promoting blood circulation joint; Caulis Sargentodoxae is longer than promoting blood circulation by removing wind, promoting the circulation of QI to relieve pain; Herba speranskiae tuberculatae, Herba Lycopodii merit can active relaxing muscles and tendons, damp-clearing pain-relievings; Lignum Sappan is longer than blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain; Caulis Trachelospermi is invigorated blood circulation with the meridian dredging and is good at, and is specially in the good medicine of relaxing muscles and tendons and activating QI and blood in the collateral; Semen Coicis merit can heat clearing away eliminating impediment after spleen invigorating.Multiple medicines compatibility, plays expelling wind and removing dampness, the effect of eliminating impediment of invigorating blood circulation altogether.

The present invention treats the inside and outside associating of ankylosing spondylitis, treating both the principal and secondary aspects of a disease, especially treats deficiency of the liver and kindey card ankylosing spondylitis and has obvious efficiency.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described.

Embodiment: a kind of medicine for the treatment of ankylosing spondylitis, mainly comprises for oral administration, external two groups of medicines, wherein oral medicine composition: Semen Cuscutae 15g, fry Radix Dipsaci 15g, Cortex Eucommiae (parched) 10g, Radix Rehmanniae Preparata 10g, Fructus Corni 10g, Rhizoma Cibotii 15g, Herba Taxilli 15g, Radix Cyathulae 15g, Fructus Psoraleae 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 8g, Herba Ecliptae 8g, Radix Angelicae Sinensis 15g, Semen Persicae 15g, Radix Paeoniae Alba 30g, Radix Glycyrrhizae 6g.Every day 1 dose, be decocted in water for oral dose.External used medicine forms: Rhizoma Et Radix Notopterygii 15g, Ramulus Cinnamomi 15g, Caulis Sargentodoxae 15g, Herba Lycopodii 15g, Herba speranskiae tuberculatae 15g, Lignum Sappan 8g, Caulis Trachelospermi 10g, Semen Coicis 30g.Patient lies supine is on steaming bed, and get in top loading gauze medicated bag and put into full-automatic stifling dipping instrument, add water middle decoction, and by affected part just to stifling window, temperature keeps about 40 DEG C, every day 1 time, at every turn stifling half an hour.During treatment, for oral administration, stifling same use 1 month is 1 course for the treatment of, and two groups use 3 months all continuously.

Clinical data

1, basic document.

Year November in January, 2013 to 2014 is routine in the patients with ankylosing spondylitis 74 that my institute is medical, be divided into matched group and each 37 examples of observation group patient at random.Matched group man 27 example, female 10 example; 24 ~ 45 years old age, year mean age (29.7 ± 2.5); The course of disease 5 months-13 years, average course of disease (5.8 ± 1.3) year; Observation group man 31 example, female 6 example; 23 ~ 43 years old age, year mean age (28.5 ± 2.4); The course of disease 6 months-11 years, average course of disease (5.4 ± 1.7) year; The physical data such as sex, age, the course of disease of two groups of patients is through statistical procedures, and no statistical difference difference (P>0.05), illustrates to have comparability between two groups.

2, diagnostic criteria.

Tcm diagnosis is made a definite diagnosis with reference to the diagnostic criteria of deficiency of the liver and kindey card ankylosing spondylitis relevant in " new Chinese medicine guideline of clinical investigations ".Patient clinical draws the ridge buttocks back of the body with lumbago, stiff deformity, wasting and atrophy of muscle, joint stuffiness, and hand is not warm, aversion to cold and preference for warmth, or soreness of the waist and knees, spermatorrhea, sexual impotence etc., pale tongue, tongue Bai Shaojin, deep and weak pulse or count accurately.

3, Therapeutic Method.

Matched group: give the match of Western medicine benefit general (the accurate word of traditional Chinese medicines: S20050058, enterprise: Shanghai CP Guojian Pharmaceutical Co., Ltd., specification: 12.5mg/ bottle) subcutaneous injection, each 25mg, 2 times weekly, every minor tick 3-4 days, dissolve with 1 milliliter of water for injection before injection, after dissolving, closed environment can in 2-8 DEG C of cold preservation 72 hours.

Observation group: to a kind of medicine therapeutic alliance for oral administration, stifling for the treatment of ankylosing spondylitis of the present invention.For oral administration: Semen Cuscutae 15g, fry Radix Dipsaci 15g, Cortex Eucommiae (parched) 10g, Radix Rehmanniae Preparata 10g, Fructus Corni 10g, Rhizoma Cibotii 15g, Herba Taxilli 15g, Radix Cyathulae 15g, Fructus Psoraleae 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 8g, Herba Ecliptae 8g, Radix Angelicae Sinensis 15g, Semen Persicae 15g, Radix Paeoniae Alba 30g, Radix Glycyrrhizae 6g.Every day 1 dose, be decocted in water for oral dose.2. stifling side is as follows: Rhizoma Et Radix Notopterygii 15g, Ramulus Cinnamomi 15g, Caulis Sargentodoxae 15g, Herba Lycopodii 15g, Herba speranskiae tuberculatae 15g, Lignum Sappan 8g, Caulis Trachelospermi 10g, Semen Coicis 30g.Patient lies supine is on steaming bed, and get in top loading gauze medicated bag and put into full-automatic stifling dipping instrument, add water middle decoction, and by affected part just to stifling window, temperature keeps about 40 DEG C, every day 1 time, at every turn stifling half an hour.

Within 1 month, be 1 course for the treatment of, treat observe the curative effect after 3 months all continuously for two groups.

4, therapeutic evaluation.

Recovery from illness: patients symptomatic disappears, joint, spinal function activity recover normal; Effective: symptom is obviously alleviated, joint, spinal function range of activity increase; Effective: symptom alleviates substantially, joint, spinal function range of activity have increased slightly; Invalid: symptom and joint, spinal function activity are unchanged.

5, comparison of therapeutic.

the symptoms such as patient's back after treatment is stiff, joint stuffiness are obviously alleviated, and the effective percentage 70.3% of matched group, comparatively observation group's effective percentage 91.9% obviously reduces, and difference has statistical significance (P < 0.05).In table 1.

table 1 liang group patients with ankylosing spondylitis clinical efficacy contrast (example)

Group	n	Cure	Effective	Effectively	Invalid	Effective percentage (%)
							Matched group	37	5	6	15	11	70.3
Observation group	37	13	11	10	3	91.9 ^a

Conclusion: a kind of Chinese medicine composition therapeutic alliance ankylosing spondylitis Be very effective for oral administration, stifling for the treatment of ankylosing spondylitis of the present invention, is better than prior art.

Claims

1. treat a medicine for ankylosing spondylitis, it is characterized in that, mainly comprise for oral administration, external two groups of medicines, wherein oral medicine composition: Semen Cuscutae 15g, fry Radix Dipsaci 15g, Cortex Eucommiae (parched) 10g, Radix Rehmanniae Preparata 10g, Fructus Corni 10g, Rhizoma Cibotii 15g, Herba Taxilli 15g, Radix Cyathulae 15g, Fructus Psoraleae 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 8g, Herba Ecliptae 8g, Radix Angelicae Sinensis 15g, Semen Persicae 15g, Radix Paeoniae Alba 30g, Radix Glycyrrhizae 6g; External used medicine forms: Rhizoma Et Radix Notopterygii 15g, Ramulus Cinnamomi 15g, Caulis Sargentodoxae 15g, Herba Lycopodii 15g, Herba speranskiae tuberculatae 15g, Lignum Sappan 8g, Caulis Trachelospermi 10g, Semen Coicis 30g; Patient lies supine is on steaming bed, and get in above-mentioned external used medicine loading gauze medicated bag and put into full-automatic stifling dipping instrument, add water middle decoction, and by affected part just to stifling window, temperature keeps about 40 DEG C, every day 1 time, at every turn stifling half an hour.