CN109303774A - A kind of emplastrum with effect of weight reducing - Google Patents
A kind of emplastrum with effect of weight reducing Download PDFInfo
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- CN109303774A CN109303774A CN201810811843.8A CN201810811843A CN109303774A CN 109303774 A CN109303774 A CN 109303774A CN 201810811843 A CN201810811843 A CN 201810811843A CN 109303774 A CN109303774 A CN 109303774A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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Abstract
The invention discloses a kind of emplastrums with effect of weight reducing.Its active constituent is oil lamp element and naringenin.Emplastrum of the invention can be affixed on navel or other fat positions, and effect of weight reducing is obvious, has no toxic side effect.The fat reducing effect of active constituent oil lamp element and naringenin single dose is not obvious, when a combination thereof in use, the effect of considerably increasing weight-reducing.Emplastrum preparation method of the invention is simple, is easy to large-scale industrial production.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of emplastrum with effect of weight reducing.
Background technique
With the variation of people life style, obesity has become the epidemic disease in global range, because of sugar caused by obesity
Urine disease, hypertension, coronary heart disease, hyperlipidemia etc. drastically influence human health, and obesity is classified as and cancer by the World Health Organization
Disease 21 century arranged side by side threatens the disease of human health most serious.
Obesity is used as a kind of disease, has had been to be concerned by more and more people and has taken appropriate measures, has moved and diet
It is the method for the best preventive obesity, but needs to adhere to for a long time, for busy modern young man, is all difficult to long-term heavily fortified point
It holds；Oral slimming drugs such as L-carnitine etc. can be with quick weight-lossing, still, and taking for a long time has side effect, and is easy to occur anti-
Bullet, antiobesity action be not lasting.
Patent 201711125949.4 discloses a kind of weight-reducing emplastrum.By the light body of tuber of pinellia lotus leaf weight-reducing, brigand
Benevolence tuber of pinellia fertilizer pastes middle benefit gas, and the stagnant logical internal organs of bitter citrus immature flower Flos Magnoliae Officinalis stomach energy rushes down lower weight-reducing, and cortex cinnamomi ginseng is lost weight Umbilicus plaster for curing, and radix bupleuri Chinese ephedra is quick
Navel applying slimming plaster of losing weight forms.The component that the ointment includes is more, and raw material is expensive, it is not easy to it prepares, it is inconvenient to use.
Patent 200710056374.5 discloses a kind of slimming and removing fat Chinese medicinal plaster.It is made of following technique: presses
Parts by weight weigh rheum officinale 15-30, rhizoma alismatis 10-18, rhizoma cyperi 10-18, saltcake 5-9 and alum 5-9, after removing sundries, are ground into
100-200 mesh fine powder is practiced by traditional handicraft honey into emplastrum.The Chinese medicinal plaster fat-reducing effect is slow, and has hunger after taking, and promotees
Into people's appetite, to be unfavorable for people's weight-reducing indirectly.
Summary of the invention
The purpose of the present invention is to provide a kind of emplastrums with effect of weight reducing.
A kind of emplastrum with effect of weight reducing, active constituent are oil lamp element and naringenin.
The oil lamp element is oil lamp A prime and/or scutellarin.
The emplastrum by following parts by weight material composition: 1-3 parts of oil lamp element, 1-3 parts of naringenin, 1-5 parts of promotor,
10-30 parts of polyacrylate pressure-sensitive, 1-4 parts of glycerol.
The promotor is azone.
The active constituent of the emplastrum further includes avicularin.
The method of the above-mentioned emplastrum with effect of weight reducing is carried out according to following operating procedure:
(1) polyacrylate pressure-sensitive and glycerol are mixed, water is added, stirs to obtain A liquid；
(2) by oil lamp element in 50-65 DEG C of water-bath, naringenin is added in A liquid, is mixed and stirred for uniform B liquid；
(3) B liquid is cooled to room temperature, promotor is added, continue stirring until mixing substantially uniformity, moulding are in blocks.
The polyacrylate pressure-sensitive and glycerol and the mass ratio that water is added are 1:(0.5-3).
The promotor is azone.
Avicularin is additionally added in the step (2).
Beneficial effects of the present invention: emplastrum of the invention can be affixed on navel or other fat positions, and effect of weight reducing is obvious,
It has no toxic side effect.The fat reducing effect of active constituent oil lamp element and naringenin single dose is not obvious, when a combination thereof in use, increasing greatly
The effect of having added weight-reducing.Emplastrum preparation method of the invention is simple, is easy to large-scale industrial production.
Specific embodiment
The present invention will be further described combined with specific embodiments below.
Embodiment 1
A kind of emplastrum with effect of weight reducing, by the material composition of following parts by weight: oil lamp A prime 2g, naringenin 2g,
Azone 3g, polyacrylate pressure-sensitive 20g, glycerol 3g.
The method of the above-mentioned emplastrum with effect of weight reducing is carried out according to following operating procedure:
(1) polyacrylate pressure-sensitive and glycerol are mixed, water is added, stirs to obtain A liquid；The polyacrylate pressure-sensitive
It is 1:1 with glycerol and the mass ratio that water is added；
(2) in 60 DEG C of water-baths by oil lamp A prime, naringenin is added in A liquid, is mixed and stirred for uniform B liquid；
(3) B liquid is cooled to room temperature, azone is added, continue stirring until mixing substantially uniformity, moulding are in blocks.
Embodiment 2
A kind of emplastrum with effect of weight reducing, by the material composition of following parts by weight: scutellarin 1g, naringenin 1g,
Azone 1g, polyacrylate pressure-sensitive 10g, glycerol 1g.
The method of the above-mentioned emplastrum with effect of weight reducing is carried out according to following operating procedure:
(1) polyacrylate pressure-sensitive and glycerol are mixed, water is added, stirs to obtain A liquid；The polyacrylate pressure-sensitive
It is 1:0.5 with glycerol and the mass ratio that water is added；
(2) in 50 DEG C of water-baths by scutellarin, naringenin is added in A liquid, is mixed and stirred for uniform B liquid；
(3) B liquid is cooled to room temperature, azone is added, continue stirring until mixing substantially uniformity, moulding are in blocks.
Embodiment 3
A kind of emplastrum with effect of weight reducing, by the material composition of following parts by weight: scutellarin 3g, naringenin 3g,
Azone 5g, polyacrylate pressure-sensitive 30g, glycerol 4g.
The method of the above-mentioned emplastrum with effect of weight reducing is carried out according to following operating procedure:
(1) polyacrylate pressure-sensitive and glycerol are mixed, water is added, stirs to obtain A liquid；The polyacrylate pressure-sensitive
It is 1:3 with glycerol and the mass ratio that water is added；
(2) in 65 DEG C of water-baths by scutellarin, naringenin is added in A liquid, is mixed and stirred for uniform B liquid；
(3) B liquid is cooled to room temperature, azone is added, continue stirring until mixing substantially uniformity, moulding are in blocks.
Embodiment 4
A kind of emplastrum with effect of weight reducing, by the material composition of following parts by weight: oil lamp A prime 2g, naringenin 2g,
Avicularin 2g, azone 3g, polyacrylate pressure-sensitive 20g, glycerol 3g.
The method of the above-mentioned emplastrum with effect of weight reducing is carried out according to following operating procedure:
(1) polyacrylate pressure-sensitive and glycerol are mixed, water is added, stirs to obtain A liquid；The polyacrylate pressure-sensitive
It is 1:1 with glycerol and the mass ratio that water is added；
(2) in 60 DEG C of water-baths by oil lamp A prime, naringenin, avicularin is added in A liquid, is mixed and stirred for uniform B liquid；
(3) B liquid is cooled to room temperature, azone is added, continue stirring until mixing substantially uniformity, moulding are in blocks.
Embodiment 5
A kind of emplastrum with effect of weight reducing, by the material composition of following parts by weight: oil lamp A prime 2g rolls up passionflower
(Passiflora cincinnata Mart.) extract 2g, azone 3g, polyacrylate pressure-sensitive 20g, glycerol 3g.
The method of the above-mentioned emplastrum with effect of weight reducing is carried out according to following operating procedure:
(1) polyacrylate pressure-sensitive and glycerol are mixed, water is added, stirs to obtain A liquid；The polyacrylate pressure-sensitive
It is 1:1 with glycerol and the mass ratio that water is added；
(2) it in 60 DEG C of water-baths by oil lamp A prime, rolls up Passion flower P.E and is added in A liquid, be mixed and stirred for uniform B
Liquid；
The extracting method of the volume Passion flower P.E are as follows: take volume passionflower blade, cross 60 meshes, add 8 times of parts by weight
Water refluxing extraction 3 times, merging filtrate is evaporated and is made；
(3) B liquid is cooled to room temperature, azone is added, continue stirring until mixing substantially uniformity, moulding are in blocks.
Embodiment 6
A kind of emplastrum with effect of weight reducing, by the material composition of following parts by weight: oil lamp A prime 2g, bright red passionflower
(Passiflora coccinea Aublet) extract 2g, azone 3g, polyacrylate pressure-sensitive 20g, glycerol 3g.
The method of the above-mentioned emplastrum with effect of weight reducing is carried out according to following operating procedure:
(1) polyacrylate pressure-sensitive and glycerol are mixed, water is added, stirs to obtain A liquid；The polyacrylate pressure-sensitive
It is 1:1 with glycerol and the mass ratio that water is added；
(2) in 60 DEG C of water-baths by oil lamp A prime, bright red Passion flower P.E is added in A liquid, is mixed and stirred for uniform B
Liquid；
The extracting method of the bright red Passion flower P.E are as follows: take bright red passionflower blade, cross 60 meshes, add 8 times of weight
The water refluxing extraction of number 3 times, merging filtrate is evaporated and is made；
(3) B liquid is cooled to room temperature, azone is added, continue stirring until mixing substantially uniformity, moulding are in blocks.
Comparative example 1
A kind of emplastrum with effect of weight reducing, by the material composition of following parts by weight: oil lamp A prime 2g, azone 3g gather
Acrylate pressure-sensitive adhesive 20g, glycerol 3g.
The method of the above-mentioned emplastrum with effect of weight reducing is carried out according to following operating procedure:
(1) polyacrylate pressure-sensitive and glycerol are mixed, water is added, stirs to obtain A liquid；The polyacrylate pressure-sensitive
It is 1:1 with glycerol and the mass ratio that water is added；
(2) oil lamp A prime is added in A liquid in 60 DEG C of water-baths, is mixed and stirred for uniform B liquid；
(3) B liquid is cooled to room temperature, azone is added, continue stirring until mixing substantially uniformity, moulding are in blocks.
Comparative example 2
A kind of emplastrum with effect of weight reducing, by the material composition of following parts by weight: naringenin 2g, azone 3g, poly- third
Olefin(e) acid ester pressure-sensitive 20g, glycerol 3g.
The method of the above-mentioned emplastrum with effect of weight reducing is carried out according to following operating procedure:
(1) polyacrylate pressure-sensitive and glycerol are mixed, water is added, stirs to obtain A liquid；The polyacrylate pressure-sensitive
It is 1:1 with glycerol and the mass ratio that water is added；
(2) naringenin is added in A liquid in 60 DEG C of water-baths, is mixed and stirred for uniform B liquid；
(3) B liquid is cooled to room temperature, azone is added, continue stirring until mixing substantially uniformity, moulding are in blocks.
Experimental example 1:
SD rat 130, male, each experimental group original body mass range is weight 120-160g, and grade is cleaning grade.Experiment
It moves and is raised in 20-25 DEG C of temperature, the laboratory of relative humidity 50-70% ventilation.Modeling animal uses " state's food medicine prison guarantorization
[2012] No. 107 " specified in high heat model feed, formula: lard 15%, sucrose 15%, casein 5%, calcium monohydrogen phosphate
0.6%, mountain flour 0.4%, mouse maintain material 64%, adapt to 7 days in animal house environment before experimental animal experiment.
Test sample is prepared:
Oil lamp A prime adds distilled water to be made into the concentration of 20.0mg/ml respectively, and stomach-filling volume is 10ml/kg.
Scutellarin adds distilled water to be made into the concentration of 20.0mg/ml respectively, and stomach-filling volume is 10ml/kg.
Naringenin adds distilled water to be made into the concentration of 20.0mg/ml respectively, and stomach-filling volume is 10ml/kg.
Avicularin adds distilled water to be made into the concentration of 20.0mg/ml respectively, and stomach-filling volume is 10ml/kg.
Volume Passion flower P.E adds distilled water to be made into the concentration of 20.0mg/ml respectively, and stomach-filling volume is 10ml/kg.
Bright red Passion flower P.E adds distilled water to be made into the concentration of 20.0mg/ml respectively, and stomach-filling volume is 10ml/kg.
Oil lamp A prime, naringenin add distilled water to be made into the concentration of 20.0mg/ml respectively, and stomach-filling volume is each 5ml/kg.
Scutellarin, naringenin add distilled water to be made into the concentration of 20.0mg/ml respectively, and stomach-filling volume is each 5ml/kg.
Oil lamp A prime, naringenin, avicularin add distilled water to be made into the concentration of 20.0mg/ml respectively, and stomach-filling volume is each
5ml/kg。
Control group stomach-filling distilled water 10ml/kg.
Experimental animal modeling: special diet induction takes SD rat (200 ± 20g), common that material raising is maintained to be fitted for 7 days
It answers, is randomly divided into 2 groups by weight after the laundering period, 10 rats give mouse and maintain feed as Normal group (Normal
Control, NC), 120 rats give high heat model feed.After feeding 2 weeks, 120 for giving high heat model feed are big
Mouse is sorted by weight gain, eliminates the lower Diet resistant rat of weight gain.By filter out 100 fat Sensitive Rats,
Weight Q1 is recorded, blank control group gives mouse simultaneously and maintains feed.
Experimental animal grouping and administration: after 8 weeks, above-mentioned rat is grouped at random by weight, model control group, normal control
Group, oil lamp A prime group, scutellarin group, naringenin group, avicularin group roll up Passion flower P.E group, bright red Passion flower P.E
Group, oil lamp A prime naringenin group, scutellarin naringenin group, oil lamp A prime naringenin avicularin group, totally 11 groups of entire experiment.
Except Normal group (gives mouse and maintains feed), other groups are given high-calorie feed and are raised 8 weeks, record weight Q2,
Calculate the weight gain Q2-Q1 of every group of mouse.
Experimental result is shown in Tables 1 and 2s:
1 each group rat Gain weight of table statistics
Note: * represents P < 0.05；* represents P < 0.01.
As can be seen from Table 1, compared with model group, the weight gain of Normal group is substantially less than model group (P < 0.01), card
Bright modeling success；Oil lamp A prime group, scutellarin group, naringenin group, avicularin group roll up Passion flower P.E group and model group phase
Than weight gain is substantially less than model group (P < 0.05), but is higher than Normal group, it was demonstrated that above-mentioned substance has the weight-reducing of rat
Certain effect still can not also make rat be restored to normal level；Bright red Passion flower P.E group is not shown with model control group
Write difference, it was demonstrated that bright red Passion flower P.E does not help the weight-reducing of rat.
2 each group rat Gain weight of table statistics
Note: * represents P < 0.05；* represents P < 0.01.
As can be seen from Table 2, compared with oil lamp A prime group, the weight gain of oil lamp A prime naringenin group is significantly lower than oil lamp A prime
Group, it was demonstrated that oil lamp A prime and naringenin, which are applied in combination, has effects that apparent synergy；Oil lamp A prime naringenin avicularin
Group is compared with oil lamp A prime group, and clearly (P < 0.01), loss of weight effect is suitable with Normal group, it was demonstrated that oil lamp first for difference
Element, naringenin, the group of avicularin are combined into effect optimal combination.
Experimental example 2:
Case 1: Mr. Wang, male, diet is unreasonable, likes carnivorous sweet food, takes in excessive power, overnutrition；Long-term alcohol
Caused hypertension, hyperlipidemia, fat, weight 100kg, 1.69 meters of height, having for the preparation of the navel paster embodiment of the present invention 1 subtracts
The emplastrum of fertile effect, every emplastrum 1g containing active constituent, exchanges cards containing all personal details and become sworn brothers daily, and after 5 months, loss of weight 18kg, blood pressure blood fat restores normal.
Case 2: Lee, female have a sweet tooth, and beverage love drinks Coca-Cola, overnutrition；With hypertension, hyperlipidemia, fertilizer
Fat, weight 85kg, 1.51 meters of height, the emplastrum with effect of weight reducing prepared by the navel paster embodiment of the present invention 4, every emplastrum is containing work
Property ingredient 1g, exchange cards containing all personal details and become sworn brothers daily, after 3 months, loss of weight 15kg, blood pressure blood fat restores normal.
Claims (9)
1. a kind of emplastrum with effect of weight reducing, which is characterized in that its active constituent is oil lamp element and naringenin.
2. according to claim 1 with effect of weight reducing emplastrum, which is characterized in that the oil lamp element be oil lamp A prime and/
Or scutellarin.
3. according to claim 1 with the emplastrum of effect of weight reducing, which is characterized in that the emplastrum is by following parts by weight
Material composition: 1-3 parts of oil lamp element, 1-3 parts of naringenin, 1-5 parts of promotor, 10-30 parts of polyacrylate pressure-sensitive, glycerol 1-4
Part.
4. according to claim 1 with the emplastrum of effect of weight reducing, which is characterized in that the promotor is azone.
5. according to claim 1 with the emplastrum of effect of weight reducing, which is characterized in that the active constituent of the emplastrum further includes
Avicularin.
6. a kind of method for preparing the emplastrum described in claim 1-5 with effect of weight reducing, which is characterized in that according to following operation
Step carries out:
(1) polyacrylate pressure-sensitive and glycerol are mixed, water is added, stirs to obtain A liquid；
(2) by oil lamp element in 50-65 DEG C of water-bath, naringenin is added in A liquid, is mixed and stirred for uniform B liquid；
(3) B liquid is cooled to room temperature, promotor is added, continue stirring until mixing substantially uniformity, moulding are in blocks.
7. the method for the emplastrum with effect of weight reducing according to claim 6, which is characterized in that the Polyacrylate Pressure Sensitive
Glue and glycerol and the mass ratio that water is added are 1:(0.5-3).
8. the method for the emplastrum with effect of weight reducing according to claim 6, which is characterized in that the promotor is azone.
9. the method for the emplastrum with effect of weight reducing according to claim 6, which is characterized in that also add in the step (2)
Enter avicularin.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810811843.8A CN109303774A (en) | 2018-07-23 | 2018-07-23 | A kind of emplastrum with effect of weight reducing |
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|---|---|---|---|
| CN201810811843.8A CN109303774A (en) | 2018-07-23 | 2018-07-23 | A kind of emplastrum with effect of weight reducing |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106857821A (en) * | 2015-12-10 | 2017-06-20 | 青岛宏致复合织造有限公司 | Diet yogurt powder |
| CN107837297A (en) * | 2017-09-25 | 2018-03-27 | 云南中医学院 | A kind of walnut shell chromocor extract is preparing the purposes in treating hyperlipidemia |
-
2018
- 2018-07-23 CN CN201810811843.8A patent/CN109303774A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106857821A (en) * | 2015-12-10 | 2017-06-20 | 青岛宏致复合织造有限公司 | Diet yogurt powder |
| CN107837297A (en) * | 2017-09-25 | 2018-03-27 | 云南中医学院 | A kind of walnut shell chromocor extract is preparing the purposes in treating hyperlipidemia |
Non-Patent Citations (3)
| Title |
|---|
| 无: "加拿大研究发现葡萄柚或有助治疗糖尿病", 《食品与发酵工业》 * |
| 蒲鹏: "野黄芩苷对代谢综合征的防治及作用机制", 《中国博士学位论文全文数据库（医药卫生科技辑）》 * |
| 黄红梅: "萹蓄的化学成分及抗氧化活性研究", 《中国优秀硕士学位论文全文数据库（医药卫生科技辑）》 * |
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