CN109276634A - A kind of Chinese medicine composition of relax bowel and defecation and preparation method thereof - Google Patents
A kind of Chinese medicine composition of relax bowel and defecation and preparation method thereof Download PDFInfo
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- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention discloses a kind of Chinese medicine composition and preparation method thereof of relax bowel and defecation, which is characterized in that includes following component: 10-50 parts of oligofructose, 5-30 parts of aloe full leaf dried powders, 10-50 parts of Semen Pruni extracts, 5-30 parts of American ginseng extracts by weight.And the effect of successively taking raw material, discharging after preparing completely, can reach relax bowel and defecation.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition of relax bowel and defecation and preparation method thereof.
Background technique
Constipation is a common clinical symptoms, and clinical manifestation is significantly reducing for defecation frequency.With economical quick
Development and the quickening of work and life rhythm are so that the stress of people increasingly increases, and the horizontal of material life is improved
So that dietary structure becomes finely, so that the disease incidence of constipation further increases.And constipation can the endotoxic storage of primosome
Product, to influence body normal physiological function.Large intestine receives remaining swill after small intestine is separated the useful from the waste, and absorbs more
Remaining moisture forms excrement, per anum and exclude external." the blue secret allusion quotation opinion of Plain Questions spirit " is said: " large intestine person, the palace of conduction, variation
Out here ".
This function of large intestine is the extension of the turbid function of stomach, while related with the respectful drop of lung.If large intestine conduction is not normal,
It may occur in which the anomalous variation of stool matter, amount and number, such as constipation.Traditional Chinese medicine thinks: large intestine, which loses, causes constipation etc. in conduction,
Can be by the bright real heat constipation of sun, stomach Qi decline, lung qi, which is stopped up, to be contained in down and loses respectful clearly cause；It can not also be transported by the deficiency of yang, the middle deficiency of vital energy is weak, intestines
The liquid factors such as dry up cause.If large intestine conduction is not smooth unfavorable, block the QI-blood circulation of large intestine passages through which vital energy circulates, then accumulates the stasis of blood long into hemorrhoid.If wet
For heat knot in large intestine, ying-qi is not all right, inverse to defend gas in meat and return and return, then can make the meromyarian natural fibre line of meat that swelling pain occur, so that
Meat degenerates purulence, and acute appendicitis occurs.
And treated at present for the traditional Chinese medicine of constipation, frequently with purgative drugs prescriptions such as rheum emodins, thus it is irritant and generate pair
Effect, child old man are difficult to be resistant to, and take for a long time and easily form dependence, will appear serious constipation after drug withdrawal, so that the state of an illness goes out
Now repeatedly and refractory feature.Therefore the treatment constipation drug for finding action temperature sum has important clinical meaning.And it is of the invention
Treatment constipation has action temperature and lasting, Small side effects, and the mechanism of action is often multiple target point, manifold effect, multi-functional comprehensive work
With.
Summary of the invention
The purpose of the invention is to overcome the shortcomings of in background technique, and a kind of good effect, the mild lasting, pair developed
Act on the small pharmaceutical composition with bowel relaxing functions.
Inventor treats patient and is up on the basis of more than ten thousand person-times, invented this in tcm clinical practice and drug research decades
Combination of oral medication.
To achieve the goals above, The technical solution adopted by the invention is as follows:
A kind of Chinese medicine composition of relax bowel and defecation includes by weight following component: 10-50 parts of oligofructose, 5-30 portions of reeds
Luxuriant growth full leaf dried powder, 10-50 part Semen Pruni extract, 5-30 parts of American ginseng extracts.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the aloe full leaf dried powder obtains as follows:
(1) fresh aloe leaf is cleaned, and drains surface moisture；
(2) Chinese aloe leaf is cut into segment, each segment length is no more than 5cm, puts baking oven into, under the conditions of 50-70 DEG C, be dried to
Moisture 3-5%, outlet；
(3) Chinese aloe leaf that will have been dried is sent to pulverizer pulverization process, and it is dry to get aloe full leaf to smash it through 50-100 mesh
Powder.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the Semen Pruni extract obtains as follows:
(1) net brush-cherry seed is taken, is placed in medicine cookeding pot, 80-120 DEG C of temperature, is stir-fried 10-20 minutes, is crushed, sieve with 100 mesh sieve；
(2) the brush-cherry seed powder crushed is placed in distillation still, the second of the mass fraction 60-80% of 3-5 times of weight of powder is added
Alcoholic solution, at a temperature of 60-80 DEG C, refluxing extraction 2-3 hours, filtering, filter residue repeated to extract primary, combined extract；
(3) extracting solution is concentrated into relative density 1.12-1.20, and drying, crushing sieves with 100 mesh sieve to get Semen Pruni extract.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the American Ginseng takes object to obtain as follows:
(1) American Ginseng is weighed, is cleaned in rinse bath, after cleaning, taking-up is dried；
(2) ginseng powder dried is broken to 50-200 mesh, adds 5-10 times of total mass of raw material of water mixing, stirs evenly,
Obtain American Ginseng paste；
(3) American Ginseng paste is put into decoction pot, is heated to 80-100 DEG C, decocted 40-60 minutes, filtering obtains filtered fluid；
(4) in aseptic room, filtered fluid is poured into stainless steel bacteria vat, is stirred, is cooled to 15-25 DEG C, raw material is added
It is small to stir 2 under conditions of 60 beats/min of revolving speed for the protease of gross weight 0.2-0.6% and the amylase of raw material gross weight 0.5-0.8%
When, and with second acid for adjusting pH value 5-7, it ferments 24 hours, filtering, filtrate obtains American ginseng extract by spray drying.
A kind of preparation method of the Chinese medicine composition of relax bowel and defecation: oligofructose, aloe full leaf dried powder, brush-cherry seed are extracted
Object, American ginseng extract put into three-dimensional mixed powder machine by weight ratio, mix 20-30 minutes, mouth is made through granulator or tablet press machine
Formulation.
Constipation is generally divided into real secret and empty secret two major classes by traditional Chinese medicine, wherein it is real secret and can be subdivided into heat secret gentle secret, it is empty
It is secret to be subdivided into the secret deficiency of vital energy, hematasthenic constipation, the deficiency of Yin are secret, the deficiency of yang is secret etc..Traditional Chinese medicine thinks that it occurs and age, diet, heredity, constitution
Etc. factors it is related, it is all in close relations with the heart, liver, spleen, lung, kidney the five internal organs.
For we according to the dialectical Cheng Fang of Traditional Chinese medical theory, aloe heat-clearing, defaecation, desinsection in side return liver, the heart, the spleen channel.It passes
System medicine think aloe have many advantages, such as catharsis action temperature with it is easy to use and acceptant.Aloe is main hydroxyl anthraquinone
Analog derivative, it was reported that aloe can release aloe-emodin in enteron aisle, play irritation discharge function, and mechanism is to promote
Enterocinesia and increase enteric cavity moisture, and main function position stimulates mucilage secretion in large intestine, plays catharsis effect.Brush-cherry seed taste
It is pungent, sweet, bitter, it is mild-natured.Main returns spleen, large intestine, small intestinl channel.The pungent energy of this product, which be manageed it, to be dissipated, and the family of the victim in a murder case will let out, and sliding benefit in sweet flavor is longer than leading large intestine
Knot gas, lubrication large intestine dry puckery and defaecation, and can manage it the aqueous vapor of whole body, so having the function of relax bowel and defecation, inducing diuresis for removing edema.
Clinically stagnation of the circulation of vital energy dry constipation of intestines are treated with it.American Ginseng: beneficial lung yin, promotes the production of body fluid to quench thirst at the clear fire of deficiency type, return heart, lung, kidney channel.It may participate in
Serum, marrow, internal organ, the synthesis of intracerebral protein and lipid-metabolism.It is aided in side and promotes the low of intestines peristalsis enhancing defecating feces excretion
Fructooligosaccharides, all medicine compatibilities, brings out the best in each other, and plays liver-regulating and kidney-nourishing, clearing away heat and moistening the bowels, antitoxic heart-soothing and sedative effect altogether, to reach improvement constipation
Purpose.
The present invention has the following advantages that pharmaceutical composition of the invention is without toxicity medicinal material compared with existing preparation
Pure Chinese medicinal preparation, have curative effect obvious, action temperature and continue, the characteristics of having no toxic side effect.
Specific embodiment
Below by specific embodiment, further description of the technical solution of the present invention, wherein the implementation enumerated
Example is only the description of the invention, without the protection scope limiting the invention in any way.
Embodiment 1
A kind of Chinese medicine composition of relax bowel and defecation includes by weight following component: 10 parts of oligofructose, 5 parts of aloe full leafs
Dry powder, 10 parts of Semen Pruni extracts, 5 parts of American ginseng extracts.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the aloe full leaf dried powder obtains as follows:
(1) fresh aloe leaf is cleaned, and drains surface moisture；
(2) Chinese aloe leaf is cut into segment, each segment length is no more than 5cm, puts baking oven into, under the conditions of 50-70 DEG C, be dried to
Moisture 3%, outlet；
(3) Chinese aloe leaf that will have been dried is sent to pulverizer pulverization process, smashes it through 50 meshes to get aloe full leaf dried powder.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the Semen Pruni extract obtains as follows:
(1) net brush-cherry seed is taken, is placed in medicine cookeding pot, 80-120 DEG C of temperature, is stir-fried 10-20 minutes, is crushed, sieve with 100 mesh sieve；
(2) the brush-cherry seed powder crushed is placed in distillation still, the ethyl alcohol that the mass fraction 60% of 3 times of weight of powder is added is molten
Liquid, at a temperature of 60-80 DEG C, refluxing extraction 2 hours, filtering, filter residue repeated to extract primary, combined extract；
(3) extracting solution is concentrated into relative density 1.12, and drying, crushing sieves with 100 mesh sieve to get Semen Pruni extract.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the American Ginseng takes object to obtain as follows:
(1) American Ginseng is weighed, is cleaned in rinse bath, after cleaning, taking-up is dried；
(2) ginseng powder dried is broken to 50 mesh, adds 5 times of total mass of raw material of water mixing, stirs evenly, obtain American Ginseng
Paste；
(3) American Ginseng paste is put into decoction pot, is heated to 80-100 DEG C, decocted 40-60 minutes, filtering obtains filtered fluid；
(4) in aseptic room, filtered fluid is poured into stainless steel bacteria vat, is stirred, is cooled to 15-25 DEG C, raw material is added
The protease of gross weight 0.2% and the amylase of raw material gross weight 0.5% are stirred 2 hours under conditions of 60 beats/min of revolving speed, are used in combination
Second acid for adjusting pH value 5 ferments 24 hours, and filtering, filtrate obtains American ginseng extract by spray drying.
A kind of preparation method of the Chinese medicine composition of relax bowel and defecation: oligofructose, aloe full leaf dried powder, brush-cherry seed are extracted
Object, American ginseng extract put into three-dimensional mixed powder machine by weight ratio, mix 20-30 minutes, mouth is made through granulator or tablet press machine
Formulation.
Embodiment 2
A kind of Chinese medicine composition of relax bowel and defecation, by weight, include following component: 30 parts of oligofructose, 20 portions of aloes are complete
Leaf dried powder, 30 parts of Semen Pruni extracts, 20 parts of American ginseng extracts.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the aloe full leaf dried powder obtains as follows:
(1) fresh aloe leaf is cleaned, and drains surface moisture；
(2) Chinese aloe leaf is cut into segment, each segment length is no more than 5cm, puts baking oven into, under the conditions of 50-70 DEG C, be dried to
Moisture 4%, outlet；
(3) Chinese aloe leaf that will have been dried is sent to pulverizer pulverization process, smashes it through 80 meshes to get aloe full leaf dried powder.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the Semen Pruni extract obtains as follows:
(1) net brush-cherry seed is taken, is placed in medicine cookeding pot, 80-120 DEG C of temperature, is stir-fried 10-20 minutes, is crushed, sieve with 100 mesh sieve；
(2) the brush-cherry seed powder crushed is placed in distillation still, the ethyl alcohol that the mass fraction 70% of 4 times of weight of powder is added is molten
Liquid, at a temperature of 60-80 DEG C, refluxing extraction 2.5 hours, filtering, filter residue repeated to extract primary, combined extract；
(3) extracting solution is concentrated into relative density 1.16, and drying, crushing sieves with 100 mesh sieve to get Semen Pruni extract.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the American Ginseng takes object to obtain as follows:
(1) American Ginseng is weighed, is cleaned in rinse bath, after cleaning, taking-up is dried；
(2) ginseng powder dried is broken to 100 mesh, adds 8 times of total mass of raw material of water mixing, stirs evenly, obtain Western
Join paste；
(3) American Ginseng paste is put into decoction pot, is heated to 80-100 DEG C, decocted 40-60 minutes, filtering obtains filtered fluid；
(4) in aseptic room, filtered fluid is poured into stainless steel bacteria vat, is stirred, is cooled to 15-25 DEG C, raw material is added
The protease of gross weight 0.4% and the amylase of raw material gross weight 0.6% are stirred 2 hours under conditions of 60 beats/min of revolving speed, are used in combination
Second acid for adjusting pH value 6 ferments 24 hours, and filtering, filtrate obtains American ginseng extract by spray drying.
A kind of preparation method of the Chinese medicine composition of relax bowel and defecation: oligofructose, aloe full leaf dried powder, brush-cherry seed are extracted
Object, American ginseng extract put into three-dimensional mixed powder machine by weight ratio, mix 20-30 minutes, mouth is made through granulator or tablet press machine
Formulation.
Embodiment 3
A kind of Chinese medicine composition of relax bowel and defecation, by weight, include following component: 50 parts of oligofructose, 30 portions of aloes are complete
Leaf dried powder, 50 parts of Semen Pruni extracts, 30 parts of American ginseng extracts.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the aloe full leaf dried powder obtains as follows:
(1) fresh aloe leaf is cleaned, and drains surface moisture；
(2) Chinese aloe leaf is cut into segment, each segment length is no more than 5cm, puts baking oven into, under the conditions of 50-70 DEG C, be dried to
Moisture 5%, outlet；
(3) Chinese aloe leaf that will have been dried is sent to pulverizer pulverization process, smashes it through 100 meshes to get aloe full leaf dried powder.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the Semen Pruni extract obtains as follows:
(1) net brush-cherry seed is taken, is placed in medicine cookeding pot, 80-120 DEG C of temperature, is stir-fried 10-20 minutes, is crushed, sieve with 100 mesh sieve；
(2) the brush-cherry seed powder crushed is placed in distillation still, the ethyl alcohol that the mass fraction 80% of 5 times of weight of powder is added is molten
Liquid, at a temperature of 60-80 DEG C, refluxing extraction 3 hours, filtering, filter residue repeated to extract primary, combined extract；
(3) extracting solution is concentrated into relative density 1.20, and drying, crushing sieves with 100 mesh sieve to get Semen Pruni extract.
A kind of Chinese medicine composition of relax bowel and defecation, wherein the American Ginseng takes object to obtain as follows:
(1) American Ginseng is weighed, is cleaned in rinse bath, after cleaning, taking-up is dried；
(2) ginseng powder dried is broken to 200 mesh, adds 10 times of total mass of raw material of water mixing, stirs evenly, obtain Western
Join paste；
(3) American Ginseng paste is put into decoction pot, is heated to 80-100 DEG C, decocted 40-60 minutes, filtering obtains filtered fluid；
(4) in aseptic room, filtered fluid is poured into stainless steel bacteria vat, is stirred, is cooled to 15-25 DEG C, raw material is added
The protease of gross weight 0.6% and the amylase of raw material gross weight 0.8% are stirred 2 hours under conditions of 60 beats/min of revolving speed, are used in combination
Second acid for adjusting pH value 7 ferments 24 hours, and filtering, filtrate obtains American ginseng extract by spray drying.
A kind of preparation method of the Chinese medicine composition of relax bowel and defecation: oligofructose, aloe full leaf dried powder, brush-cherry seed are extracted
Object, American ginseng extract put into three-dimensional mixed powder machine by weight ratio, mix 20-30 minutes, mouth is made through granulator or tablet press machine
Formulation.
Embodiment 4
A kind of Chinese medicine composition of relax bowel and defecation, by weight, include following component: 30 parts of oligofructose, 10 portions of aloes are complete
Leaf dried powder, 10 parts of Semen Pruni extracts, 20 parts of American ginseng extracts.
Remaining is the same as embodiment 1.
Embodiment 5
A kind of Chinese medicine composition of relax bowel and defecation, by weight, include following component: 40 parts of oligofructose, 20 portions of aloes are complete
Leaf dried powder, 15 parts of Semen Pruni extracts, 10 parts of American ginseng extracts.
Remaining is the same as embodiment 1.
Embodiment 6
A kind of Chinese medicine composition of relax bowel and defecation, by weight, include following component: 25 parts of oligofructose, 30 portions of aloes are complete
Leaf dried powder, 30 parts of Semen Pruni extracts, 30 parts of American ginseng extracts.
Remaining is the same as embodiment 1.
Claims (5)
1. a kind of Chinese medicine composition of relax bowel and defecation, it is characterised in that: by weight, include following component: 10-50 parts oligomeric
Fructose, 5-30 part aloe full leaf dried powder, 10-50 parts of Semen Pruni extracts, 5-30 parts of American ginseng extracts.
2. a kind of Chinese medicine composition of relax bowel and defecation according to claim 1, it is characterised in that: the aloe full leaf is dry
Powder obtains as follows:
(1) fresh aloe leaf is cleaned, and drains surface moisture；
(2) Chinese aloe leaf is cut into segment, each segment length is no more than 5cm, puts baking oven into, under the conditions of 50-70 DEG C, be dried to
Moisture 3-5%, outlet；
(3) Chinese aloe leaf that will have been dried is sent to pulverizer pulverization process, and it is dry to get aloe full leaf to smash it through 50-100 mesh
Powder.
3. a kind of Chinese medicine composition of relax bowel and defecation according to claim 1, it is characterised in that: the brush-cherry seed extracts
Object obtains as follows:
(1) net brush-cherry seed is taken, is placed in medicine cookeding pot, 80-120 DEG C of temperature, is stir-fried 10-20 minutes, is crushed, sieve with 100 mesh sieve；
(2) the brush-cherry seed powder crushed is placed in distillation still, the second of the mass fraction 60-80% of 3-5 times of weight of powder is added
Alcoholic solution, at a temperature of 60-80 DEG C, refluxing extraction 2-3 hours, filtering, filter residue repeated to extract primary, combined extract；
(3) extracting solution is concentrated into relative density 1.12-1.20, and drying, crushing sieves with 100 mesh sieve to get Semen Pruni extract.
4. a kind of Chinese medicine composition of relax bowel and defecation according to claim 1, it is characterised in that: the American Ginseng takes object
It obtains as follows:
(1) American Ginseng is weighed, is cleaned in rinse bath, after cleaning, taking-up is dried；
(2) ginseng powder dried is broken to 50-200 mesh, adds 5-10 times of total mass of raw material of water mixing, stirs evenly,
Obtain American Ginseng paste；
(3) American Ginseng paste is put into decoction pot, is heated to 80-100 DEG C, decocted 40-60 minutes, filtering obtains filtered fluid；
(4) in aseptic room, filtered fluid is poured into stainless steel bacteria vat, is stirred, is cooled to 15-25 DEG C, raw material is added
It is small to stir 2 under conditions of 60 beats/min of revolving speed for the protease of gross weight 0.2-0.6% and the amylase of raw material gross weight 0.5-0.8%
When, and with second acid for adjusting pH value 5-7, it ferments 24 hours, filtering, filtrate obtains American ginseng extract by spray drying.
5. a kind of preparation method of the Chinese medicine composition of relax bowel and defecation according to claim 1, it is characterised in that: will be oligomeric
Fructose, aloe full leaf dried powder, Semen Pruni extract, American ginseng extract put into three-dimensional mixed powder machine by weight ratio, mix 20-30
Minute, oral preparation is made through granulator or tablet press machine.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109924501A (en) * | 2019-04-04 | 2019-06-25 | 武汉一元堂生物科技股份有限公司 | A kind of extraction process of brush-cherry seed for health care |
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2018
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109924501A (en) * | 2019-04-04 | 2019-06-25 | 武汉一元堂生物科技股份有限公司 | A kind of extraction process of brush-cherry seed for health care |
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| WD01 | Invention patent application deemed withdrawn after publication |