CN109260391A - A kind of pharmaceutical composition and preparation method thereof for treating urinary calculus - Google Patents
A kind of pharmaceutical composition and preparation method thereof for treating urinary calculus Download PDFInfo
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- CN109260391A CN109260391A CN201811358732.2A CN201811358732A CN109260391A CN 109260391 A CN109260391 A CN 109260391A CN 201811358732 A CN201811358732 A CN 201811358732A CN 109260391 A CN109260391 A CN 109260391A
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- endothelium corneum
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 206010007027 Calculus urinary Diseases 0.000 title claims abstract description 11
- 208000009911 Urinary Calculi Diseases 0.000 title claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 91
- 239000004575 stone Substances 0.000 claims abstract description 37
- 235000014676 Phragmites communis Nutrition 0.000 claims abstract description 35
- 210000003038 endothelium Anatomy 0.000 claims abstract description 35
- 240000008042 Zea mays Species 0.000 claims abstract description 32
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims abstract description 32
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 32
- 235000005822 corn Nutrition 0.000 claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 13
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 10
- 235000019441 ethanol Nutrition 0.000 claims description 52
- 239000006228 supernatant Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 17
- 239000003085 diluting agent Substances 0.000 claims description 16
- 239000003937 drug carrier Substances 0.000 claims description 14
- 239000006071 cream Substances 0.000 claims description 13
- 239000000706 filtrate Substances 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 13
- 230000001376 precipitating effect Effects 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 3
- 235000007164 Oryza sativa Nutrition 0.000 claims 3
- 239000010977 jade Substances 0.000 claims 3
- 235000009566 rice Nutrition 0.000 claims 3
- 240000002853 Nelumbo nucifera Species 0.000 claims 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000013049 sediment Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000027939 micturition Effects 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract 1
- 210000003708 urethra Anatomy 0.000 description 9
- 206010007026 Calculus urethral Diseases 0.000 description 4
- 201000009160 urethral calculus Diseases 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 206010046555 Urinary retention Diseases 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010013554 Diverticulum Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000006568 Urinary Bladder Calculi Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 210000002640 perineum Anatomy 0.000 description 1
- 210000004706 scrotum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention relates to a kind of pharmaceutical composition and preparation method thereof for treating urinary calculus, which is made of the drug of following parts by weight: Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma, by alcohol extracting, water decoct etc. techniques be made.By Clinical observation, pharmaceutical composition of the present invention can be obviously improved frequent micturition patient episode's frequency, and prevention urinary calculus is significant in efficacy, and effective percentage has reached 90%.
Description
Technical field
The present invention relates to field of medicine invention, and in particular to a kind of pharmaceutical composition for treating urinary calculus and its preparation side
Method.
Background technique
Urethral calculus (urethral calculus) can also be divided into primary and secondary two class, primary urethral calculus
It is rare.The calculus of urethra is clinically betided mostly from urinary system thereon, especially bladder, may also occur at urethra rest
It is indoor.The main incarceration of calculus is in the urethra of prostatic part, navicular fossa of urethra or outer urethral orifice in male patient.It is apt to occur in 1~10
Year children, 90% is male.Clinical manifestation is superfine urine line, the retention of urine and urethra pain.Most of urethral calculus is kidney, urine output
Pipe, vesical calculus arrange downwards per urethra and caused by urethras.Also a small number of calculus are primary in ankylurethria, infection, retention
Tumour, mucosa injury, diverticulum and foreign matter etc..Incarcerated stone can cause dysuria, urine line to attenuate or sound of rain pattering shape in urethra, sometimes
There is urine flow interruption and the retention of urine.Acute urinary retention then occurs for obstruction completely.Urination has apparent pain sometimes, and is radiated to yin
Stem head.Hind urethra calculus has perineum and scrotum portion pain.Stone location has obvious pain pain and tenderness, the part if concurrent infection
The pain increased, and urethral orifice has purulent secretion, irritation sign of bladder aggravation.Currently, there is no good methods for treatment urinary calculus, originally
Inventor in order to solve this problem, has developed a kind of new drug.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical compositions of urinary calculus.
It is a further object of the present invention to provide a kind of preparation methods of the pharmaceutical composition of urinary calculus.
The present invention provides a kind of pharmaceutical composition of urinary calculus, which is made of the drug of following parts by weight:
10-50 parts of Sculellaria barbata, 15-60 parts of herba lysimachiae, 10-35 parts of endothelium corneum gigeriae galli, 10-30 parts of stone reed, 10-40 parts of Herba lygodii, corn stigma
15-55 parts.
Preferably, pharmaceutical composition of the present invention is made of the drug of following parts by weight: 15-45 parts of Sculellaria barbata, gold
20-55 parts of money grass, 12-32 parts of endothelium corneum gigeriae galli, 12-28 parts of stone reed, 13-37 parts of Herba lygodii, 20-50 parts of corn stigma.
It is further preferred that pharmaceutical composition of the present invention is made of the drug of following parts by weight: Sculellaria barbata 20-40
Part, 25-50 parts of herba lysimachiae, 15-30 parts of endothelium corneum gigeriae galli, 15-25 parts of stone reed, 18-32 parts of Herba lygodii, 25-45 parts of corn stigma.
Still more preferably, pharmaceutical composition of the present invention is made of the drug of following parts by weight: Sculellaria barbata 25-
35 parts, 30-45 parts of herba lysimachiae, 18-28 parts of endothelium corneum gigeriae galli, 18-23 parts of stone reed, 22-30 parts of Herba lygodii, 30-40 parts of corn stigma.
Still more preferably, pharmaceutical composition of the present invention is made of the drug of following parts by weight: Sculellaria barbata 30
Part, 38 parts of herba lysimachiae, 25 parts of endothelium corneum gigeriae galli, 21 parts of stone reed, 26 parts of Herba lygodii, 35 parts of corn stigma.
Pharmaceutical composition of the present invention also contains pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention be solid pharmaceutical preparation or liquid preparation, the solid pharmaceutical preparation be tablet, capsule,
Granula or pill；The liquid preparation is oral solution.
The preparation method of pharmaceutical composition of the present invention the following steps are included: by Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli,
Stone reed, Herba lygodii, corn stigma pulverize and sieve, and are uniformly mixed with pharmaceutically acceptable carrier or diluent, are prepared into preparation.
The preparation method of pharmaceutical composition of the present invention the following steps are included:
1) by herba lysimachiae, endothelium corneum gigeriae galli, stone reed, that Radix Salviae Miltiorrhizae is ground into fine powder is spare；
2) 3 times of amount water are added to decoct 2-4 times Sculellaria barbata, Herba lygodii, corn stigma, 1-2 hours each, collecting decoction is quiet
It sets, filters, filtrate is concentrated into clear cream, and to cold, adding 2-3 times to measure 75% ethyl alcohol makes to precipitate, and takes supernatant, and precipitating plus 2-4 times are measured
75% ethyl alcohol, stirring stand 12-16 hours, take supernatant, merge alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, by medicinal extract
It is dried, crushed into fine powder, pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
The preparation method of preferred pharmaceutical composition of the present invention the following steps are included:
1) by herba lysimachiae, endothelium corneum gigeriae galli, stone reed, that Radix Salviae Miltiorrhizae is ground into fine powder is spare；
2) 3 times of amount water are added to decoct 3 times Sculellaria barbata, Herba lygodii, corn stigma, 1 hour every time, collecting decoction was stood, filter
It crosses, filtrate is concentrated into clear cream, to cold, 2 times of 75% ethyl alcohol of amount is added to make to precipitate, and takes supernatant, precipitating plus 3 times of 75% ethyl alcohol of amount, stirs
It mixes, stands 15 hours, take supernatant, merge alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, extract dry is ground into thin
Powder, is added pharmaceutically acceptable carrier or diluent is uniformly mixed, and preparation is made.
The parts by weight can be unit of weight well known to the field of medicaments such as μ g, mg, g, kg.
The meaning of amount refers to the weight ratio of medicinal material again.
The invention has the following advantages:
By Clinical observation, pharmaceutical composition of the present invention can obviously treat urinary calculus patient episode frequency, effective percentage
Reach 90%.
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Embodiment 1
Prescription: Sculellaria barbata 10g, herba lysimachiae 15g, endothelium corneum gigeriae galli 10g, stone reed 10g, Herba lygodii 10g, corn stigma 15g.
Preparation method:
1) by herba lysimachiae, endothelium corneum gigeriae galli, stone reed, that Radix Salviae Miltiorrhizae is ground into fine powder is spare；
2) 3 times of amount water are added to decoct 2 times Sculellaria barbata, Herba lygodii, corn stigma, 1 hour every time, collecting decoction was stood, filter
It crosses, filtrate is concentrated into clear cream, to cold, 2 times of 75% ethyl alcohol of amount is added to make to precipitate, and takes supernatant, precipitating plus 2 times of 75% ethyl alcohol of amount, stirs
It mixes, stands 12 hours, take supernatant, merge alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, extract dry is ground into thin
Powder；The starch for accounting for uniformly mixed fine powder weight 1/5 is added, is packed into capsule, capsule is made.
Embodiment 2
Prescription: Sculellaria barbata 50g, herba lysimachiae 60g, endothelium corneum gigeriae galli 35g, stone reed 30g, Herba lygodii 40g, corn stigma 55g.
Preparation method:
3 times of amount water are added to decoct 2 times Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma, 1 is small every time
When, collecting decoction is stood, and filtration, filtrate is concentrated into clear cream, and to cold, add 2 times of 75% ethyl alcohol of amount to make to precipitate, take supernatant, precipitating
Add 3 times of 75% ethyl alcohol of amount, stir, stand 14 hours, take supernatant, merges alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, it will
Extract dry is ground into fine powder；Pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
Embodiment 3
Prescription: Sculellaria barbata 15g, herba lysimachiae 20g, endothelium corneum gigeriae galli 12g, stone reed 12g, Herba lygodii 13g, corn stigma 20g.
Preparation method:
3 times of amount water are added to decoct 2 times Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma, 1 is small every time
When, collecting decoction is stood, and filtration, filtrate is concentrated into clear cream, and to cold, add 2 times of 75% ethyl alcohol of amount to make to precipitate, take supernatant, precipitating
Add 3 times of 75% ethyl alcohol of amount, stir, stand 14 hours, take supernatant, merges alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, it will
Extract dry is ground into fine powder；Pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
Embodiment 4
Prescription: Sculellaria barbata 45g, herba lysimachiae 55g, endothelium corneum gigeriae galli 32g, stone reed 28g, Herba lygodii 37g, corn stigma 50g.
Preparation method:
3 times of amount water are added to decoct 2 times Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma, 1 is small every time
When, collecting decoction is stood, and filtration, filtrate is concentrated into clear cream, and to cold, add 2 times of 75% ethyl alcohol of amount to make to precipitate, take supernatant, precipitating
Add 3 times of 75% ethyl alcohol of amount, stir, stand 14 hours, take supernatant, merges alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, it will
Extract dry is ground into fine powder；Pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
Embodiment 5
Prescription: Sculellaria barbata 20g, herba lysimachiae 25g, endothelium corneum gigeriae galli 15g, stone reed 15g, Herba lygodii 18g, corn stigma 25g.
Preparation method:
3 times of amount water are added to decoct 2 times Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma, 1 is small every time
When, collecting decoction is stood, and filtration, filtrate is concentrated into clear cream, and to cold, add 2 times of 75% ethyl alcohol of amount to make to precipitate, take supernatant, precipitating
Add 3 times of 75% ethyl alcohol of amount, stir, stand 14 hours, take supernatant, merges alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, it will
Extract dry is ground into fine powder；Pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
Embodiment 6
Prescription: Sculellaria barbata 40g, herba lysimachiae 50g, endothelium corneum gigeriae galli 30g, stone reed 25g, Herba lygodii 32g, corn stigma 45g.
Preparation method:
3 times of amount water are added to decoct 2 times Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma, 1 is small every time
When, collecting decoction is stood, and filtration, filtrate is concentrated into clear cream, and to cold, add 2 times of 75% ethyl alcohol of amount to make to precipitate, take supernatant, precipitating
Add 3 times of 75% ethyl alcohol of amount, stir, stand 14 hours, take supernatant, merges alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, it will
Extract dry is ground into fine powder；Pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
Embodiment 7
Prescription: Sculellaria barbata 25g, herba lysimachiae 30g, endothelium corneum gigeriae galli 18g, stone reed 18g, Herba lygodii 22g, corn stigma 30g.
Preparation method:
3 times of amount water are added to decoct 2 times Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma, 1 is small every time
When, collecting decoction is stood, and filtration, filtrate is concentrated into clear cream, and to cold, add 2 times of 75% ethyl alcohol of amount to make to precipitate, take supernatant, precipitating
Add 3 times of 75% ethyl alcohol of amount, stir, stand 14 hours, take supernatant, merges alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, it will
Extract dry is ground into fine powder；Pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
Embodiment 8
Prescription: Sculellaria barbata 35g, herba lysimachiae 45g, endothelium corneum gigeriae galli 28g, stone reed 23g, Herba lygodii 30g, corn stigma 40g.
Preparation method:
3 times of amount water are added to decoct 2 times Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma, 1 is small every time
When, collecting decoction is stood, and filtration, filtrate is concentrated into clear cream, and to cold, add 2 times of 75% ethyl alcohol of amount to make to precipitate, take supernatant, precipitating
Add 3 times of 75% ethyl alcohol of amount, stir, stand 14 hours, take supernatant, merges alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, it will
Extract dry is ground into fine powder；Pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
Embodiment 9
Prescription: Sculellaria barbata 30g, herba lysimachiae 38g, endothelium corneum gigeriae galli 25g, stone reed 21g, Herba lygodii 26g, corn stigma 35g.
Preparation method:
3 times of amount water are added to decoct 2 times Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma, 1 is small every time
When, collecting decoction is stood, and filtration, filtrate is concentrated into clear cream, and to cold, add 2 times of 75% ethyl alcohol of amount to make to precipitate, take supernatant, precipitating
Add 3 times of 75% ethyl alcohol of amount, stir, stand 14 hours, take supernatant, merges alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, it will
Extract dry is ground into fine powder；Pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
Although above having used general explanation, specific embodiment and test, the present invention is made to retouch in detail
State, but on the basis of the present invention, it can be made it is some modify or improve, this is aobvious and easy to those skilled in the art
See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Range.
Claims (10)
1. a kind of pharmaceutical composition for treating urinary calculus, it is characterised in that the pharmaceutical composition by following parts by weight drug system
At: 10-50 parts of Sculellaria barbata, 15-60 parts of herba lysimachiae, 10-35 parts of endothelium corneum gigeriae galli, 10-30 parts of stone reed, 10-40 parts of Herba lygodii, corn
It must be 15-55 parts.
2. pharmaceutical composition according to claim 1, it is characterised in that the pharmaceutical composition by following parts by weight drug
It is made: 15-45 parts of Sculellaria barbata, 20-55 parts of herba lysimachiae, 12-32 parts of endothelium corneum gigeriae galli, 12-28 parts of stone reed, 13-37 parts of Herba lygodii, jade
Rice must be 20-50 parts.
3. pharmaceutical composition according to claim 2, it is characterised in that the pharmaceutical composition by following parts by weight drug
It is made: 20-40 parts of Sculellaria barbata, 25-50 parts of herba lysimachiae, 15-30 parts of endothelium corneum gigeriae galli, 15-25 parts of stone reed, 18-32 parts of Herba lygodii, jade
Rice must be 25-45 parts.
4. pharmaceutical composition according to claim 3, it is characterised in that the pharmaceutical composition by following parts by weight drug
It is made: 25-35 parts of Sculellaria barbata, 30-45 parts of herba lysimachiae, 18-28 parts of endothelium corneum gigeriae galli, 18-23 parts of stone reed, 22-30 parts of Herba lygodii, jade
Rice must be 30-40 parts.
5. pharmaceutical composition according to claim 4, it is characterised in that the pharmaceutical composition by following parts by weight drug
It is made: 30 parts of Sculellaria barbata, 38 parts of herba lysimachiae, 25 parts of endothelium corneum gigeriae galli, 21 parts of stone reed, 26 parts of Herba lygodii, 35 parts of corn stigma.
6. pharmaceutical composition according to claim 1-5, which is characterized in that the pharmaceutical composition also contains pharmacy
Upper acceptable carrier or diluent.
7. pharmaceutical composition according to claim 6, which is characterized in that described pharmaceutical composition is solid pharmaceutical preparation or liquid
Preparation, the solid pharmaceutical preparation are tablet, capsule, granule or pill；The liquid preparation is particle electuary.
8. a kind of method for preparing the described in any item pharmaceutical compositions of claim 1-5, which is characterized in that this method include with
Lower step: Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma are pulverized and sieved, with pharmaceutically acceptable load
Body or diluent are uniformly mixed, and are prepared into preparation.
9. a kind of method for preparing any one of claim 1-5 described pharmaceutical composition, which is characterized in that this method includes following
Step: 3 times of amount water are added to decoct 2-4 times Sculellaria barbata, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma, each 1-2 is small
When, collecting decoction is stood, and filtration, filtrate is concentrated into clear cream, and to cold, adding 2-3 times to measure 75% ethyl alcohol makes to precipitate, and takes supernatant, is sunk
It forms sediment plus 2-4 times is measured 75% ethyl alcohol, stir, stand 12-16 hours, take supernatant, merge alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into
Extract dry is ground into fine powder by medicinal extract；Pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
10. the method for pharmaceutical composition according to claim 9, which is characterized in that method includes the following steps: by half
Lotus, herba lysimachiae, endothelium corneum gigeriae galli, stone reed, Herba lygodii, corn stigma add 3 times of amount water to decoct 2 times, and 1 hour every time, collecting decoction was quiet
It sets, filters, filtrate is concentrated into clear cream, to cold, add 2 times of 75% ethyl alcohol of amount to make to precipitate, takes supernatant, precipitating adds 3 times of 75% second of amount
Alcohol, stirring stand 14 hours, take supernatant, merge alcohol liquid, ethyl alcohol is recovered under reduced pressure and is condensed into medicinal extract, and extract dry crushes
At fine powder；Pharmaceutically acceptable carrier is added or diluent is uniformly mixed, preparation is made.
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| CN201811358732.2A CN109260391A (en) | 2018-11-15 | 2018-11-15 | A kind of pharmaceutical composition and preparation method thereof for treating urinary calculus |
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| CN201811358732.2A CN109260391A (en) | 2018-11-15 | 2018-11-15 | A kind of pharmaceutical composition and preparation method thereof for treating urinary calculus |
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