CN109260282A

CN109260282A - Cosmeceutical, plant extracts and its preparation method and application

Info

Publication number: CN109260282A
Application number: CN201811189030.6A
Authority: CN
Inventors: 田中哲郎
Original assignee: Sprout Co Ltd
Current assignee: Sprout Co Ltd
Priority date: 2018-03-19
Filing date: 2018-10-12
Publication date: 2019-01-25

Abstract

The present invention relates to cosmeceuticals, plant extraction liquid and its preparation method and application.The cosmetics are that the raw material of the loguat leaf after washing and drying and/or the ingredient containing amarogentin is impregnated in wine, the liquid of at least two moon removal loguat leaf derived above is impregnated under conditions of room temperature, sealing, being protected from light, the liquid is used directly as cosmeceutical, the as described cosmeceutical；The cosmetics cannot mix the hydrate in addition to wine during the preparation process.Cosmeceutical of the invention is pure natural preparation, normal temperature condition ensure that nonrefractory ingredient and volatile component are not destroyed in the raw material of loguat leaf and/or the ingredient containing amarogentin, purifies to greatest extent using ensure that close to natural method long period of soaking and extracts the effective component in raw material.

Description

Cosmeceutical, plant extracts and its preparation method and application

Technical field

The present invention relates to cosmetic field more particularly to a kind of cosmeceutical, a Plant Extracts and its for making Make the application of cosmetics, health care product and drug.

Background technique

Cosmeceutical currently on the market generally passes through addition arbutin, kojic acid, niacinamide, vitamin C derivatives etc. Chemical addition agent achievees the effect that whitening spot-removing, antiphlogistic antibacterial etc..These cosmetics usually contain a large amount of chemical addition agent, Expensive and most of safeties cause anxiety, and actual effect is not also significant.

The leaf of loquat leaf system rosaceous plant loquat, recklessly rich in amarogentin, volatile oil, saponin(e, flavones, three notes acid, β Radish element, water-soluble polysaccharide, enzyme, protein and organic acid isoreactivity ingredient have very high economic value and medical value.With Loguat leaf has been reported for the research that raw material extracted and prepared Related product.

Patent document 1 discloses a kind of preparation method of loquat-leaf extract and its application in pharmaceutical field.The document Using polar organic solvent, high temperature extracts the medicinal ingredient in loguat leaf powder in a short time.This method can be fast in a short time Speed carries out the extraction of medicinal ingredient, but due to the complex chemical composition of loguat leaf, operates at a higher temperature, can be to loquat The nonrefractory ingredient and volatile component contained in leaf causes irreversible destruction, it is difficult to play its effect to greatest extent.

Patent document 2 discloses a kind of loquat-leaf extract in ultraviolet injury repair and promotes the purposes in energetic supersession. The document decocts loguat leaf using first high-temperature water, high concentration ethanol extraction is added later, solids extraction object is made, and solid-state is mentioned Object is taken to be used as additive to prepare cosmetics.But high-temperature water decoct mode can destroy the nonrefractory ingredient in loguat leaf with And volatile component, it is equally difficult to play its effect to greatest extent.

For the problems in the relevant technologies, currently no effective solution has been proposed.

Existing technical literature

Patent document 1: Chinese patent CN1939443A

Patent document 2: Chinese patent CN104666145A

Summary of the invention

In view of the above problems, it is an object of the present invention to provide a kind of cosmeceuticals.

The cosmeceutical is pure natural preparation, and normal temperature condition ensure that the original of loguat leaf and/or the ingredient containing amarogentin Nonrefractory ingredient and volatile component are not destroyed in material, ensure that greatest extent using close to natural method long period of soaking Purifying and extract the effective component in loguat leaf.

Second object of the present invention is to provide a kind of preparation method of above-mentioned cosmeceutical.

Third object of the present invention is to provide a Plant Extracts.

Fourth object of the present invention is to provide a kind of preparation method of above-mentioned plant extraction liquid.

Of the invention the 5th is designed to provide the application that a kind of above-mentioned plant extraction liquid is used to prepare cosmeceutical.

Of the invention the 6th is designed to provide a kind of above-mentioned plant extraction liquid and is used to prepare health care product and/or drug Using.

Of the invention the 7th is designed to provide a kind of above-mentioned plant extraction liquid and is used to prepare answering for food and/or drink With.

Of the invention the 8th is designed to provide the application that a kind of above-mentioned plant extraction liquid is used to prepare daily necessities.

To realize that above-mentioned first purpose, the present invention provide a kind of cosmeceutical,

The raw material of loguat leaf after washing and drying and/or the ingredient containing amarogentin is impregnated in wine, in room temperature, close It is impregnated under conditions of sealing, being protected from light and obtains the liquid of the raw material of removal loguat leaf and/or the ingredient containing amarogentin, the liquid is made For cosmeceutical use；

The cosmeceutical does not mix the hydrate in addition to wine during the preparation process.

Preferably, the raw material of the ingredient containing amarogentin is selected from one of the following raw material or a variety of:

Loquat, Loquat Seeds, Loquat Seeds or the skin of fruit, almond, apricot, hawthorn, cherry, nectarine, peach, plum Son, flex seed, Apple Seeds, alfalfa, plum, bamboo shoots, brown rice, soybean, red bean, buckwheat, sesame, cassava and dried plum.

Preferably, the soaking time is at least two more than the moon.

Preferably, soaking time of the raw material of the loguat leaf and/or the ingredient containing amarogentin in wine is 6-12 months.

Preferably, the ethyl alcohol that the Spirit and/or concentration that the wine is 35 degree of alcoholic strength or more are 35% or more.

Preferably, mass ratio of the raw material and wine of the loguat leaf and/or the ingredient containing amarogentin when impregnating is 1:4- 20。

Preferably, the loguat leaf is selected from the loquat more than at least a year in growth period during 2 month of December to next year Leaf on tree.

Preferably, the loguat leaf is impregnated in pretreatment preceding in wine includes:

Cleaning treatment removes cotton wool, dirt on loguat leaf；

It is dried, by the loft dried under field conditions (factors) of the loguat leaf after cleaning；

Rubbing processing, cuts into bulk for the loguat leaf after drying, carries out rubbing processing；

Hydrate, grease impurities cannot be mixed into the drying, rubbing treatment process.

Preferably, it during the raw material of the loguat leaf and/or the ingredient containing amarogentin impregnates in wine, needs periodically Repeatedly vibration stimulation is carried out to the raw material of loguat leaf and/or the ingredient containing amarogentin.

Preferably, the cosmeceutical cannot be mixed into moisture or impurity when in use, using before the cosmetics and/or Using in the cosmetics, needing to carry out warm processing to skin.

To realize that above-mentioned second purpose, the present invention provide a kind of preparation method of cosmeceutical, which comprises

The hydrate in addition to wine is not mixed in the preparation process of the cosmeceutical.

Preferably, soaking time of the raw material of the loguat leaf and/or the ingredient containing amarogentin in wine is at least two moon More than.

Cleaning treatment removes cotton wool, dirt on loguat leaf；

To realize that above-mentioned third purpose, the present invention provide a Plant Extracts,

The extracting solution is that the raw material of the loguat leaf after washing and drying and/or the ingredient containing amarogentin is impregnated in wine In, it is impregnated under conditions of room temperature, sealing, being protected from light and obtains the liquid of removal loguat leaf；

The extracting solution cannot mix the hydrate in addition to wine during the preparation process.

Cleaning treatment removes cotton wool, dirt on loguat leaf；

To realize that above-mentioned 4th purpose, the present invention provide a kind of preparation method of above-mentioned plant extraction liquid, the method Include:

The raw material of loguat leaf after washing and drying and/or the ingredient containing amarogentin is impregnated in wine, in room temperature, close It is impregnated under conditions of sealing, being protected from light and obtains the liquid of the raw material of removal loguat leaf and/or the ingredient containing amarogentin, the as described plant Extracting solution；

The hydrate in addition to wine is not mixed in the preparation process of the plant extraction liquid.

Cleaning treatment removes cotton wool, dirt on loguat leaf；

To realize that above-mentioned 5th purpose, the present invention provide plant extraction liquid as described above and be used to prepare answering for cosmetics With.Preferably, the cosmetics are emulsion agent, cream ointment, gelling agent, pulvis, spray.

To realize above-mentioned 6th purpose, the present invention provide plant extraction liquid as described above be used to prepare health care product and/ Or the application in drug.

Preferably, the health care product and/or drug are for preventing and/or treating skin disease.

Preferably, the skin disease includes burn, scald, traumatic injury, scuffing, bite by mosquitos wound, sebaceous cyst, sebaceous glands Tumour, acne, tinea.

Preferably, the health care product and/or drug are for preventing and/or treating mouth disease.

Preferably, the mouth disease includes toothache, swelling and aching of gum, stomatitis, canker sore.

Preferably, the health care product and/or drug are for preventing and/or treating throat diseases.

Preferably, the throat diseases include cough, sphagitis, tonsillitis.

To realize above-mentioned 7th purpose, the present invention provide plant extraction liquid as described above be used to prepare food and/or The application of drink.

Preferably, the food includes cake, chocolate, steamed bun, jelly, candy, syrup, replenishers, ice cream, plane Ice, ice cream.

Preferably, the drink includes tea, fruit juice, coffee, milk shake, drinks.

To realize that above-mentioned 8th purpose, the present invention provide plant extraction liquid as described above and be used to prepare answering for daily necessities With.

Preferably, the daily necessities include toothpaste, mouthwash, perfumed soap, hand cleanser, shampoo, shower cream.

The invention has the advantages that:

Cosmetics of the invention use the extracting solution being made using pure natural method directly as cosmetics, at It is point pure natural, it is highly-safe.

Cosmetics of the invention, containing through a long time soak at room temperature, what is purified and mention to greatest extent takes loguat leaf effective Ingredient.Normal temperature condition will not destroy nonrefractory ingredient and volatile component in loguat leaf, such as amarogentin, volatile oil, Saponin(e, carrotene, protein, various enzymes etc.；Long period of soaking can guarantee that extraction is abundant again.

Cosmetics preparation method of the invention, without heating, easy to operate, process is pure natural, does not depend on large scale equipment, It is environmentally protective without using any additive.

Plant extraction liquid of the invention also has other than having effects that whitening spot-removing, antibacterial anti-inflammatory for cosmetics The effect of prevention and/or treatment skin disease, mouth disease, throat diseases.

Plant extract liquid and preparation method thereof of the invention, without heating, easy to operate, process is pure natural, does not depend on large size Equipment does not use any additive, and extracting solution and loguat leaf have economic value.

Detailed description of the invention

Fig. 1 shows the preparation flow figure of the cosmeceutical in first embodiment.

Fig. 2A is shown in first embodiment using the face skin state diagram before cosmeceutical.

Fig. 2 B is shown in first embodiment using the face skin state diagram after cosmeceutical 2 months.

Fig. 2 C is shown in first embodiment using the face skin state diagram after cosmeceutical 4 months.

Fig. 3 A shows the right crus of diaphragm scald position skin state diagram that the same day occurs for scald in second embodiment.

Fig. 3 B shows the right crus of diaphragm scald position skin shape after treating 2 days in second embodiment using loquat leaf extract State figure.

Fig. 3 C shows the right crus of diaphragm scald position skin shape after treating 3 days in second embodiment using loquat leaf extract State figure.

Fig. 3 D shows the right crus of diaphragm scald position skin shape after treating 8 days in second embodiment using loquat leaf extract State figure.

Fig. 3 E shows the right crus of diaphragm scald position skin after treating 11 days in second embodiment using loquat leaf extract State diagram.

Fig. 3 F shows the right crus of diaphragm scald position skin after treating 14 days in second embodiment using loquat leaf extract State diagram.

Fig. 3 G shows the right crus of diaphragm scald position skin after treating 23 days in second embodiment using loquat leaf extract State diagram.

Fig. 3 H shows the right crus of diaphragm scald position skin after treating 51 days in second embodiment using loquat leaf extract State diagram.

Specific embodiment

Technical solution in order to enable those skilled in the art to better understand the present invention, with reference to the accompanying drawing and specific embodiment party The present invention will be described in detail for formula.In the drawings, for constituent element identically or comparably, identical label is marked. It is below only preferred forms of the invention, the present invention is not limited in following the description.

First embodiment

Present embodiment is related to a kind of cosmeceutical.

The cosmeceutical are as follows: the loguat leaf after washing and drying is impregnated in wine, in room temperature, the item for sealing, being protected from light The liquid that at least two moon removal loguat leaf derived above is impregnated under part, uses directly as cosmetics, that is, is directly packaged in makeup It is used in product packing container as cosmetics, the as described cosmeceutical.

It should be noted that the cosmetics are during the preparation process, especially impregnate in encapsulation process, cannot mix except wine Any hydrate in addition, this is to guarantee that cosmetics are capable of the key factor of long-term preservation.

The existing extractive technique to loguat leaf includes heating or high temperature processing step.Since the ingredient of loguat leaf is multiple It is miscellaneous, contain such as amarogentin, volatile oil, saponin(e, carrotene, protein, various enzymes, organic acid etc., high temperature can be to loquat The nonrefractory ingredient and volatile component contained in leaf causes irreversible destruction, can especially cause to amarogentin irreversible Destruction, it is difficult to play its effect to greatest extent.

At present about the application of loguat leaf, usually it is added to loquat-leaf extract as additive in commodity.Especially Cosmetic field cooperates as additive or with other Chinese herbal medicines to make facial mask etc..At this time for convenience addition and It saves, extract is generally fabricated to solid-state.It is extracted from liquid and solid is made, centre needs to be concentrated, be evaporated under reduced pressure, is dry etc. Multiple steps have been further exacerbated by the destruction to effective component in extract.

The cosmetics of present embodiment, effective component are through wine long-time room temperature, the loquat for sealing, being protected from light immersion and obtaining Leaf extract, and by the extracting solution directly as cosmetics use, i.e., be directly encapsulated as cosmetics finished product, do not need it is any after Processing step, the process for preparing and being packaged into cosmetics do not mix any auxiliary material, regulator or chemical addition agent, pure day So, highly-safe.

In loguat leaf containing the protectiving ultraviolets effective component such as flavone compound, terpenoid and it is anti-oxidant effectively Ingredient, since present embodiment is without heat treatment, and long period of soaking under conditions of sealing, being protected from light, to the greatest extent It purifies and is extracted the ingredients such as the amarogentin in loguat leaf, saponin(e, polyphenol, vitamin C, beta carotene, and be sufficiently reserved The activity of these effective components so that the obvious while contained amarogentin of the whitening spot-removing effect of the cosmetics, saponin(e, The ingredients such as tannic acid, tartaric acid also have effects that analgesia and antibacterial anti-inflammatory.Although and without containing the addition such as preservative Agent, which still is able to long-term preservation, or even saves after 10 years, and active constituent is still valid.

Fig. 1 shows the preparation flow figure of the whitening cosmetics in first embodiment.

As shown in fig. 1, firstly, in step S1, loguat leaf is carried out selected.

As one specific example of present embodiment, for this sentences the weather conditions in EMUs for Kyushu of Japan area, loguat leaf Use the leaf on the loquat more than at least a year in growth period during 2 month of December to next year.It is preferred that the 1 of cold period The loquat leaf fallen is cut before and after month, according to the weather conditions of Japan, is easier to harvest the leaf of bottle green plumpness at this time.When So, according to country variant, the Different climate in area, the exact date for acquiring the leaf of bottle green plumpness is not also identical.Such as China, since China is vast in territory, each province and city climate difference is big, as long as the leaf of bottle green plumpness can be collected, no matter Which kind of on date.Cutaway processing is carried out for the leaf of deformation according to the condition of the loguat leaf of use.Certainly, may be used The leaf is not handled and is directly used.

In step S2, loguat leaf is started the cleaning processing, removes cotton wool, the dirt on loguat leaf.

As one specific example of present embodiment, loquat leaf is impregnated 15 points or so into the water, with brush, sea The mode that silk floss, felt etc. do not injure leaf is removed and is cleaned to the light brown wool of dirt, the leaf back side on leaf, and according to The situation of water changes new water into and persistently carries out operation.

Further, the removal of wool draws circle mode using from the root of leaf towards leaf top, alternatively, straight line side Formula wiping, can more easily remove.

Further, after cleaning treatment, the moisture on leaf is sufficiently wiped with the absorptive substances such as towel or cloth, paper It wipes, into the drying operation of loguat leaf.

In step S3, loguat leaf is dried, that is, hang the loguat leaf after cleaning under field conditions (factors) dry It is dry.

As one specific example of present embodiment, loguat leaf in a manner of closely not connecting, not be overlapped one is opened one Individually suspension, dry 1~5 of ventilation place, under sunlight or shady place was dry.

It should be noted that dry degree, should sufficiently dry, to remove the moisture that may cause corruption, and cannot mistake Drying is spent, to prevent from destroying effective component.As dry standard, the side of leaf becomes scroll-like towards leaf central axis and is It can.

Any foreign matter is prevented to be mixed into dry process.

In step S4, rubbing processing is carried out to loguat leaf, that is, the loguat leaf after drying is cut into bulk, is rubbed Processing.

As one specific example of present embodiment, the loguat leaf after drying is cut into 2~3 centimetres of four directions of standard, And rubbing massage is carried out to loguat leaf with hand.The dynamics of rubbing is adjusted according to the state of leaf.

Loguat leaf is sheared into frustillatum, the area of section of leaf can be increased, so as to from the surface of leaf, the back side, with And more ingredients are extracted at section, it is drawn to the maximum extent conducive to by the effective component of loguat leaf inherently.To Pi Rake leaf is rubbed, be not loguat leaf is rubbed it is broken, first is that in order to increase the folding line cross section of leaf, second is that at random in order to enable Associative perception is presented in loguat leaf.The shape of different sizes of loguat leaf every is also different.By drying, rubbing processing can make its size, Shape is unified as far as possible, so that extraction can be stablized when impregnating in wine by putting it into.

It should be noted that the impurity such as hydrate, grease cannot be mixed into rubbing treatment process, rubber can be used for example The appurtenances such as gloves advantageously ensure that cosmetics long-term preservation.

It, will treated that loguat leaf impregnates in wine under conditions of room temperature, sealing, being protected from light through rubbing in step S5 Processing.Soaking time is at least 2 months or more.

For example, soaking time of the loguat leaf in wine is 6-12 months.According to country, the difference of region, loquat leaf composition The time dissolved in wine is most short for two half a months of summer, 4 half a months of winter.Impregnate liquid when starting be it is transparent, with mentioning Dissolving in for object is taken to gradually become dark brown (amber Bose).When liquid becomes dark brown, it is meant that the end of immersion treatment.

It selects to extend soaking time to extract more multicomponent, to obtain the higher liquid of concentration；If but being The effect of being possible to during dipping up to 1 year or more loguat leaf can be corrupt, in turn results in contained in script loguat leaf (bitter apricot Benevolence glycosides etc.) it is destroyed.Therefore, most short dip time is preferably 6 months, and longest dip time is preferably 1 year.

For example, the ethyl alcohol that Spirit and/or concentration that used wine is 35 degree of alcoholic strength or more are 35% or more.

" Spirit " described in present embodiment refers to that manufacturing process is to first pass through brewing, after distilled after it is cooling Alcoholic solution drink, including white wine, liquor, brandy, whiskey, vodka, rum of height number for arriving etc..

The preferred white wine of Spirit or liquor in present embodiment.

It is soluble in the flavones, saponin(e, amarogentin of alcohol due to not only containing in loguat leaf, but also has albumen soluble easily in water Matter, enzyme, polysaccharide, amino acid etc., therefore the wine of high concentration or ethanol solution is selected to be impregnated, Pi can be extracted to the maximum extent Effective component in rake leaf, while the sterilization of alcohol in high concentration, and long-term soak at room temperature can be realized, it keeps away Exempt from the corruption of product, it being capable of long-term preservation.

For example, the mass ratio of loguat leaf and wine when impregnating is 1:4-20.

Specifically, for the leaf 150g-300g of the loquat after dry rubbing, the Alcohol degree of 1.8L or so room temperature is poured into In any in 35 degree or more of white wine or liquor class or ethyl alcohol.After the covering tightly and close of container, will be placed in will not direct projection arrive daylight Safe dark cold place.Blend compounds band winds container cover and body contacts portion, to improve tightness.

Container bottom is coated with the padded coaming of polyurethane, rubber etc., increases sense of stability.

Repeatedly vibration stimulation periodically can be carried out to loguat leaf.It is preferred that 1 week 2-3 times by the way of up and down to container Shaken several times to tens times.By being stimulated, the extraction of loguat leaf can promote.It is further preferred that two or three week 1 time benefit The leaf of loquat upper and lower in container is swapped with dedicated utensil, more promotes the extraction of loguat leaf.

It is to allow loguat leaf to be in " resting state " by stabilization that container bottom, which spreads padded coaming and obtains sense of stability,. The meaning that loguat leaf in the resting state is rocked up and down, is to pierce loguat leaf equably more Swash, enables wine farthest effective component extracting.

In step S6, the liquid obtained after loguat leaf and immersion is separated.

Specifically, it can be separated, be carried out in two steps using sieve device.First divided using the biggish sieve device of mesh Liquid is purified from loguat leaf and liquid, then using mesh lesser sieve device, wool, tiny residue are separated Out.

In step S7, the dark brown liquid isolated is directly packaged in toiletry bag packaging container and obtains medicinal makeup Product.

That is, the liquid isolated requires no any post-processing, any chemical addition agent need not also be added, directly Cosmetics containers are encapsulated into be sold as cosmetics.The cosmetics are pure natural, the effect of in addition to whitening spot-removing, also have and control Treat the medicinal efficacy of acne, acne, dermatocyst etc..

Preferred package applies some make up container for low dose of container, to guarantee that the liquid in container has used in a short time Finish, prevents because cosmetic industry is lost caused by introducing dirt in use process.

It should be noted that the cosmetics are during the preparation process, in especially dry, rubbing, immersion and encapsulation process, no The impurity such as any hydrate and the grease in addition to wine can be mixed, such as needs to wear rubber gloves and is operated, this is to protect Card cosmetics are capable of the key factor of long-term preservation.

Above-mentioned cosmeceutical can also be using the raw material that will contain amarogentin ingredient other than dipping loguat leaf obtains It is obtained with the mode that loguat leaf impregnates jointly.Preparation method becomes loguat leaf and ingredient containing amarogentin in addition to the raw material of addition Raw material, other preparation process are same as above.

Further, the raw material containing amarogentin ingredient is one of following or a variety of:

Wherein, the addition of above-mentioned raw materials, can be according to the hobby and demand, consideration using effect, rejecting allergy of particular person The various factors such as former, safety and economy carry out the selection of type and quantity.It selects from above-mentioned raw materials and a variety of to generate liquid Body, whichever kind can be realized using amarogentin as main component.The former material that cooperation country variant is planted, survived Material, can be realized the effect of the amarogentin of main component.According to the raw material of cooperation, other than the effect of amarogentin, Also according to individual physique, " cosmeceutical " for there are individual differences is produced.

Above-mentioned cosmeceutical cannot be mixed into moisture or impurity when in use, using before the cosmetics and/or use the change In cosmetic, warm processing first preferably is carried out to skin.

Such as before directly coating, skin is cleaned with hot water or heat steams skin, to promote skin pore to expand, widening angle Matter lamellar spacing, more efficiently absorption cosmetic actives；Or liquid is dipped with the gauze of warm, absorbent cotton and is coated in flesh Skin, to promote percutaneous absorption.

When being coated, coated in the way of being close to and pressing skin by finger or coating with utensil.It is preferred that with The mode for drawing circle is coated or to press effect more preferable.

In addition to this it is possible to use coating method below by utensil:

The cosmetics are placed in spray apparatus, are sprayed in a manner of spray form；

Cosmetics are fabricated to rod type emulsifiable paste shape, effective component is coated on skin referring to the mode for applying lipstick；

Cosmetics are fabricated to ointment, emulsifiable paste shape, and is dipped and is coated on skin with finger；

Or liquid, emulsifiable paste, ointment shape cosmetics are encapsulated into cast utensil, each used time is expressed into finger, then applies (the similar mode squeezed toothpaste out of a tube) is layed on skin；

Or in the outlet end of cast utensil, similar gauze or spongiform applying head are set, liquid in cast utensil or After lotion soaks applying head, applying head is directly contacted to skin and is smeared；

Or the mode that applying head changes ball into is smeared and also may be used.

In addition, the loguat leaf through wine long period of soaking also has together in addition to dark brown liquid is used effectively as cosmetics The effect of sample, can be fabricated to medicine bag etc..It is put into when for cleaning face or brothers' immersion, it might even be possible to directly be attached to leaf It is used on skin, not will cause waste.

Specific application example:

Subject: the age 40 years old healthy male；

Test purpose: being coated on subject's face skin for above-mentioned cosmeceutical (only containing loguat leaf), tests its beauty White freckle effect；

Test condition: it is each primary daily morning and evening, after warm water cleans face and heat steams skin, cosmetics are dipped with absorbent cotton Skin is close to and is pressed to liquid, is coated in a manner of drawing circle.

As shown in Figure 2 A, subject's face skin is partially yellow, the colour of skin is obscure, and encircled portion is an obvious blackspot at cheek.

Fig. 2 B is shown using the face skin state diagram after cosmeceutical 2 months of first embodiment.

As shown in Figure 2 B, after cosmetics coating in 2 months, the skin state of subject has improvement, and the colour of skin highlights, black The blackspot color that color circle is irised out is obviously thin out.Also, in the use process of the cosmetics, the face of subject does not occur The adverse reactions such as allergy, erubescence swell and itch, clogging of pores.

Fig. 2 C is shown using the face skin state diagram after cosmeceutical 4 months of first embodiment.

As shown in Figure 2 C, after long-time service in 4 months, the skin state of subject has and clearly improves, dark yellow It disappears, the colour of skin bleaches, and more pleasantly surprised, the blackspot at cheek thoroughly disappears.In fact, subject is passing through 3 months left sides After right use, the blackspot at cheek has just been vanished from sight, while skin state has also significantly improved.

As it can be seen that the cosmeceutical can be used for a long time, any adverse reaction of subject will not be caused, safety is good, And show surprising whitening spot-removing effect afterwards by long-term use.

In addition, the cosmetics for saving 10 years that subject prepares before also using applicant 10 years, find after use, With whitening effect identical with the cosmetics of existing preparation, and any discomfort sense of skin is not caused.Illustrate the change Cosmetic can long-term preservation, it is still valid to save the active constituent after 10 years.

Second embodiment

Present embodiment is related to a kind of loquat leaf extract.

The extracting solution is that the loguat leaf after washing and drying is impregnated in wine, room temperature, seal, be protected from light under conditions of soak Steep the dark brown liquid of at least two moon removal loguat leaf derived above；The extracting solution cannot mix during the preparation process except wine with Outer hydrate.

The loquat leaf extract also has pre- other than having effects that whitening spot-removing, antibacterial anti-inflammatory etc. for cosmetics The effect of anti-and/or treatment skin disease, mouth disease, throat diseases, can without any following process, directly smearing or Oral medication related disease.

The loquat leaf extract can be with long-term preservation, or even saves after 10 years, and active constituent is still valid.

As an example, soaking time of the loguat leaf in wine is 6-12 months.

As an example, the Spirit and/or concentration that wine used in impregnating is 35 degree of alcoholic strength or more are 35% or more Ethyl alcohol.

As an example, the mass ratio of loguat leaf and wine when impregnating is 1:4-20.

As an example, loguat leaf is selected from the Pi more than at least a year in growth period during 2 month of December to next year Leaf on rake tree.

As an example, the pretreatment before loguat leaf is impregnated in wine includes:

Cleaning treatment removes cotton wool, dirt on loguat leaf；

During loguat leaf impregnates in wine, repeatedly vibration stimulation periodically preferably is carried out to loguat leaf.

The description of step S1-S6 in the specific preparation method reference first embodiment of the loquat leaf extract, herein It is not repeated.

The loquat leaf extract due to containing the protectiving ultraviolets effective component such as flavone compound, terpenoid and Anti-oxidant effective component has apparent whitening spot-removing, antimicrobial and anti-inflammation efficacy, can be used in preparing cosmeceutical.

The case where according to actual use, in addition to being directly used as liquid make-up, it can also optionally be fabricated to emulsion agent, frost The different types of cosmetics such as paste, gelling agent, pulvis or spray.

Due in above-mentioned loquat leaf extract contain amarogentin, saponin(e, polyphenol, vitamin C, beta carotene, tannic acid, Tartaric acid, citric acid etc., therefore there are a variety of medicinal efficacies.Such as wherein most strikingly amarogentin, have anti- Cancer, antitumaous effect, analgesic activity, U.S. flesh effect, can promote hair growth, eliminate skin speckle wrinkle, to burn, scald or Person's throat inflammation has good curative effect.And the amarogentin content in extracting solution is moderate, will not cause hardship because of a large amount of uses The symptoms such as almond glycosides poisoning.

In addition, saponin(e have antimicrobial and anti-inflammation efficacy, polyphenol, vitamin C and beta carotene all have anticancer it is anti-oxidant, increase The effect of strong resistance, tannic acid have biocidal efficacies, and tartaric acid, citric acid, which have effects that relieve fatigue, improves immunity etc. Deng.The loquat leaf extract that the above method is prepared sufficiently is extracted these effective components, and completely remains these effectively The activity of ingredient.Therefore, above-mentioned loquat leaf extract can be used for preparing the health care product and/or drug with multiple efficacies, or Prepare varieties of food items, drink, daily necessities etc..

Further, present embodiment further relates to a Plant Extracts.The plant extraction liquid and above-mentioned loguat leaf Extracting solution the difference is that: the extracting solution is by the loguat leaf after washing and drying and/or containing amarogentin ingredient Raw material is impregnated in wine, remaining content is same as above.

Wherein, the raw material containing amarogentin ingredient is one of following or a variety of:

Amarogentin is present in mostly in the seed of fruit.In modern dietary structure, fruit and seed is eaten up together Eating habit has been abandoned, and causes people to be usually less able to absorb these natural amarogentin food, so that as prevention It gradually disappears from a menu with the laetrile (i.e. amarogentin) for the effective component for treating a variety of diseases.Present embodiment Plant extraction liquid, the environment that laetrile is arrived in intake can be easy in usual life by being just desirable to creation one.

As shown the effective component of above-mentioned various raw materials in the following table 1.

The effective component of raw material of the table 1 containing amarogentin ingredient

It as shown in table 1, is the effective component of the various raw materials containing amarogentin.It can be independent in above-mentioned plant extraction liquid Using one of above-mentioned raw materials or a variety of as main component；Addition above-mentioned raw materials can also be aided with using loguat leaf as main component One of or it is a variety of.The composition of plant extraction liquid can be deployed arbitrarily according to actual needs.

For example, making that " apricot " is added in " loguat leaf " as main component, to can get " bitter contained by loguat leaf Almond glycosides ingredient " additional " beta carotene ", " organic acid ", " food fiber " " potassium " these effective components.In addition, " apricot " is planted In the state Jia Lifoniya in the U.S. or China, therefore it can realize that scene is bought and generates liquid, to enlist the services of " semen armeniacae amarae Glycosides " ingredient.

As an example, said extracted liquid can be used for preparing prevention and/or treat skin disease health care product and/or Drug.

For example, above-mentioned skin disease includes burn, scald, traumatic injury, scuffing, bite by mosquitos wound, sebaceous cyst, sebum glandular sac Swollen, acne, tinea etc..

As an example, said extracted liquid can be used for preparing prevention and/or treat mouth disease health care product and/or In drug.

For example, above-mentioned mouth disease includes toothache, swelling and aching of gum, stomatitis, canker sore etc..

As an example, said extracted liquid can be used for preparing prevention and/or treat throat diseases health care product and/or Drug.

For example, above-mentioned throat diseases include cough, sphagitis, tonsillitis etc..

As an example, said extracted liquid can be used for preparing food and/or drink.

For example, above-mentioned food includes cake, chocolate, steamed bun, jelly, candy, syrup, dietary supplementation agent, ice cream, plane Ice, ice cream etc., the food of all kinds of forms that can add the loquat leaf extract.

For example, above-mentioned drink includes tea, fruit juice, coffee, milk shake, drinks etc., it is all to add the loguat leaf The drink of all kinds of forms of extracting solution.

As an example, said extracted liquid can be also used for preparing daily necessities.

For example, above-mentioned daily necessities include toothpaste, mouthwash, perfumed soap, hand cleanser, shampoo, shower cream etc., it is any can Add all kinds of daily necessities of the loquat leaf extract.

Have effects that above-mentioned drug, health care product or food, drink, daily necessities in addition to being used to prepare as raw material, this The extracting solution (including loquat leaf extract and plant extraction liquid) of embodiment, without can also directly make through any following process Smearing or oral medication related disease are carried out for drug.

For example, after cleaning affected part, dipping extracting solution for burning, scalding with finger and patting affected part skin or periphery It is smeared, or hot compress is carried out according to situation.For traumatic injury, strain etc., cold wet compress, Zhi Houwen first are carried out with extracting solution Soak.It can choose directly coating loquat leaf extract, gauze etc. can also be immersed and spread on affected part.Certainly, it also can be used directly Loguat leaf.As the number of coating, i.e. effectively, but as better effect, the coating of left and right five times a day is optionally carried out within 1 day 1, If it is possible that it is preferred that being coated after balneation.

For example, for treating the mouth disease mode that perhaps throat diseases can choose mouth containing, gargle or drink.Drink Used time optionally waters down extracting solution to 6 times or so, 1-3 times on the 1st.When sucking, gargling, optionally extracting solution is watered down to 6 times Left and right, it is i.e. effective once a day.

Certainly, said extracted liquid is as drug, health care product or daily necessities in use, can also be referring to first embodiment In the smearing ways and means of cosmetics enumerated, be administered by utensil, such as spray apparatus, cast utensil etc., also can Reach equally even preferably effect.

In addition, the extraction liquid and preparation method thereof of present embodiment, is not only made the liquid with multiple efficacies, after wine impregnates Loguat leaf or other raw materials also there is same effect, can be fabricated to medicine bag etc. use, will not waste.

Specific application example:

Subject: the patient through boiling water burn right crus of diaphragm, patient's right crus of diaphragm are deep II degree of scald through dermatology's diagnosis；

Test purpose: being directly coated on subject affected part skin for above-mentioned loquat leaf extract, tests its treatment burn Effect；

Test condition: it once a day, takes four drop loquat leaf extracts to be coated on subject's right crus of diaphragm and scalds position skin.

As shown in Figure 3A, by rats after severe scald burn at the right crus of diaphragm ankle of patient, scalding area is big, and there is purulence blood on surface, generates violent Pain, the same day are deep II degree of scald through dermatology's diagnosis, and doctor explicitly indicates that " convalescence at least needing 1 month ".

After loquat leaf extract treats couple of days, as shown in Fig. 3 B, 3C, the pain in affected part is relieved, and is scalded Hurt the skin that edge is festered and begin with and is improved.

After loquat leaf extract is treated 8 days, as shown in Figure 3D, the position purulence blood disappearance of festering of illing skin has been opened The incrustation of beginning large area.Dermatology is gone to check again, doctor is so astonished fastly to what affected part was restored, and diagnosis is corrected as " restoring after a week ".

After loquat leaf extract is treated 11 days and 14 days, as shown in Fig. 3 E, 3F, affected part pain is completely disappeared, and is die Skin incrustation after fall, expose fair and tender neoplastic skin.Go to dermatology to check for the third time after 14 days, diagnosis be " rehabilitation, It is complete only to need to wait for skin regeneration ".

After loquat leaf extract is treated 23 days, as illustrated in Figure 3 F, the skin of right crus of diaphragm scald position necrosis is completely fallen off, powder Tender new skin is all grown,

After loquat leaf extract is treated 51 days, as shown in figure 3h, right crus of diaphragm scalds area skin regeneration ending, regenerated skin Skin reaches unanimity with surrounding skin color, it is surprising that not leaving ugly scar or melanin deposition.These Beneficial effect will be attributed to the fact that anti-inflammatory possessed by the loquat leaf extract in present embodiment, analgesia, antibacterial, skin repair Effect.

The application further includes following content:

One Plant Extracts,

The extracting solution is that the raw material of the loguat leaf after washing and drying and/or the ingredient containing amarogentin is impregnated in wine In, at least two moon removal loguat leaf derived above and/or ingredient containing amarogentin are impregnated under conditions of room temperature, sealing, being protected from light Raw material liquid；

Further, the raw material of the ingredient containing amarogentin is selected from one of the following raw material or a variety of:

Further, soaking time of the raw material of the loguat leaf and/or the ingredient containing amarogentin in wine is 6-12 Month.

Further, the ethyl alcohol that the Spirit and/or concentration that the wine is 35 degree of alcoholic strength or more are 35% or more.

Further, mass ratio of the raw material and wine of the loguat leaf and/or the ingredient containing amarogentin when impregnating is 1: 4-20。

Further, the loguat leaf is selected from the Pi more than at least a year in growth period during 2 month of December to next year Leaf on rake tree.

Further, the loguat leaf is impregnated in pretreatment preceding in wine includes:

Cleaning treatment removes cotton wool, dirt on loguat leaf；

Further, it is periodically right during the raw material of the loguat leaf and/or the ingredient containing amarogentin impregnates in wine The raw material of loguat leaf and/or the ingredient containing amarogentin carries out repeatedly vibration stimulation.

The preparation method of one Plant Extracts, which comprises

The raw material of loguat leaf after washing and drying and/or the ingredient containing amarogentin is impregnated in wine, in room temperature, close The liquid of the raw material of at least two moon removal loguat leaf derived above and/or the ingredient containing amarogentin is impregnated under conditions of sealing, being protected from light Body, the as described loquat leaf extract；

As above any plant extraction liquid is used to prepare the application of cosmetics.

Further, the cosmetics are emulsion agent, cream ointment, gelling agent, pulvis, spray.

As above any plant extraction liquid is used to prepare the application of health care product and/or drug.

Further, the health care product and/or drug are for preventing and/or treating skin disease.

Further, the skin disease includes burn, scald, traumatic injury, scuffing, bite by mosquitos wound, sebaceous cyst, sebum Adenocele, acne, tinea.

Further, the health care product and/or drug are for preventing and/or treating mouth disease.

Further, the mouth disease includes toothache, swelling and aching of gum, stomatitis, canker sore.

Further, the health care product and/or drug are for preventing and/or treating throat diseases.

Further, the throat diseases include cough, sphagitis, tonsillitis.

As above any plant extraction liquid is used to prepare the application of food and/or drink.

Further, the food include cake, chocolate, steamed bun, jelly, candy, syrup, dietary supplementation agent, ice swash Icepro, water ice, ice cream.

Further, the drink includes tea, fruit juice, coffee, milk shake, drinks.

As above any plant extraction liquid is used to prepare the application of daily necessities.

Further, the daily necessities include toothpaste, mouthwash, perfumed soap, hand cleanser, shampoo, shower cream.

Principle that embodiment of above is intended to be merely illustrative of the present and the illustrative embodiments used, however this hair It is bright to be not limited thereto.For those skilled in the art, in the feelings for not departing from spirit and substance of the present invention Under condition, various changes and modifications can be made therein.These variations and modifications are also considered as protection scope of the present invention.

Claims

1. a kind of cosmeceutical, it is characterised in that:

The raw material of loguat leaf after washing and drying and/or the ingredient containing amarogentin is impregnated in wine, in room temperature, seals, keep away The liquid that the raw material of at least two moon removal loguat leaf derived above and/or the ingredient containing amarogentin is impregnated under conditions of light, by institute Liquid is stated to use as the cosmeceutical；

2. cosmeceutical according to claim 1, it is characterised in that: the raw material of the ingredient containing amarogentin be selected from One of the following raw material is a variety of:

Loquat, Loquat Seeds, Loquat Seeds or the skin of fruit, almond, apricot, hawthorn, cherry, nectarine, peach, plum, Asia Numb seed, Apple Seeds, alfalfa, plum, bamboo shoots, brown rice, soybean, red bean, buckwheat, sesame, cassava and dried plum.

3. cosmeceutical according to claim 1, it is characterised in that: the loguat leaf and/or ingredient containing amarogentin Soaking time of the raw material in wine be 6-12 months.

4. cosmeceutical according to claim 1, it is characterised in that: the Spirit that the wine is 35 degree of alcoholic strength or more And/or the ethyl alcohol that concentration is 35% or more.

5. cosmeceutical according to claim 1, it is characterised in that: the loguat leaf and/or ingredient containing amarogentin Raw material and wine impregnate when mass ratio be 1:4-20.

6. cosmeceutical according to claim 1, it is characterised in that: the loguat leaf is selected from December to next year 2 months Leaf on loquat during part, more than at least a year in growth period.

7. cosmeceutical according to claim 1, it is characterised in that:

The loguat leaf, which is impregnated in pretreatment preceding in wine, includes:

Cleaning treatment removes cotton wool, dirt on loguat leaf；

8. cosmeceutical according to claim 1, it is characterised in that: the loguat leaf and/or ingredient containing amarogentin Raw material during impregnated in wine, repeatedly vibration thorn periodically is carried out to the raw material of loguat leaf and/or the ingredient containing amarogentin Swash.

9. cosmeceutical according to claim 1, it is characterised in that: the cosmeceutical cannot be mixed into when in use Moisture or impurity carry out warm processing to skin using before the cosmetics and/or using in the cosmetics.

10. a kind of preparation method of cosmeceutical, which is characterized in that the described method includes: