CN109249617A - A kind of 3D drop printer and its method for preparing hanging drop - Google Patents
A kind of 3D drop printer and its method for preparing hanging drop Download PDFInfo
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- CN109249617A CN109249617A CN201811168233.7A CN201811168233A CN109249617A CN 109249617 A CN109249617 A CN 109249617A CN 201811168233 A CN201811168233 A CN 201811168233A CN 109249617 A CN109249617 A CN 109249617A
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- drop
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
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Abstract
The invention discloses a kind of 3D drop printer and its methods for preparing hanging drop.The present invention uses a kind of hydrogel with shear shinning property for water phase, has supporting role to the oil phase drop being suspended in water phase.Using the 3D printing technique based on digital model file, the three-dimensional motion of printer head is accurately controlled by digital model file, simultaneously by syringe pump control oil phase three-dimensional space feeding, thus Precise Control of Oil phase drop position in three dimensions and droplet size.Specific spatial arrangement mode is used to oil phase drop, the ratio of oily phase and water phase can be optimized, while the threedimensional model with specific shape being made of oil phase drop can also be printed, is with a wide range of applications in every field.
Description
Technical field
The present invention relates to microemulsion fields, and in particular to a method of hanging drop is prepared using 3D drop printer.
Background technique
Hanging drop is the microemulsion that a kind of oiliness drop is suspended in steadily in the long term among water phase, wherein oil mutually may include each
Kind oil components, can be widely applied to new material processing, and exploitation new product is applied to the fields such as cosmetics, medicine, food.It passes
The hanging drop system that system is prepared by cutting method, there are multiple problems.The system prepared first by cutting method, can not
Dispersion process is accurately controlled, is easily formed and is mutually separated, causes the oily ratio mutually in water phase lower, it is difficult to improve.Secondly
By cutting method prepare system, size droplet diameter is different, dispersion is uneven, position is unordered, limit its develop new material with
Application in designing new product, the present invention use 3D drop printing technique, can be precisely controlled to droplet size and position,
The hanging drop system for preparing specific structure carries out Precise spraying to material and product, enhances function effect of visualization, expand it
Application range.
In the present invention using one kind based on digital model file, object is constructed by layer-by-layer printing
Fusion sediment formula 3D printing technique.3D printing technique can convert complicated threedimensional model to a series of simple two dimensions and make
It makes, thus arbitrarily complicated model can be generated in the case where not having to mold.
The present invention transform the consumptive material feed mechanism of conventional melt sedimentation type 3D printer as the pressure of control fluid flow
Liquid is printed the drop of uniform particle diameter such as syringe pump or peristaltic pump by control mechanism by printing head in hydrogel.
Compared with preparing hanging drop by cutting method, 3D printer prepares suspension microlayer model energy Precise Control of Oil drop in three-dimensional
In addition the position in space controls each drop in three-dimensional by the particular arrangement optimization oil of oiliness drop mutually with the ratio of water phase
Spatial position can print the threedimensional model of specific shape, expand application of the technology in every field.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of method for preparing hanging drop based on 3D printing technique, solution
Determined it is traditional the problem that hanging drop is difficult to improve oily phase accounting is prepared with microflow control technique, this method is simple and easy to do and can obtain
The drop that size is uniform, position is controllable is obtained, and the threedimensional model of specific shape composed of droplets can be prepared according to specific requirements,
The technology is with a wide range of applications in the fields such as cosmetics, craftwork.
To achieve the above object, the present invention provides following solution:
The present invention discloses a kind of 3D printer for preparing hanging drop, including three-dimensional mobile print system first, described
The mobile print system of three-dimensional include Z axis hoistable platform, X-axis mobile mechanism, Y-axis moving mechanism and printing head, X-axis moving machine
The movement that structure, Y-axis moving mechanism are used to that the printing head to be driven to realize in X/Y plane；The Z axis hoistable platform is for real
The adjusting of Z-direction distance between existing region to be printed and printing head；The 3D printer further includes pressure control mechanism
And conduit；The pressure control mechanism is connected by conduit with printing head.
The present invention is using horizontal plane as X/Y plane, and Z-direction is the vertically direction with the horizontal plane, and horizontally to the right for X
Axis positive direction is horizontally forward Y-axis positive direction, is straight up Z axis positive direction.
Preferably, the pressure control mechanism is syringe pump or peristaltic pump.
Preferably, the 3D printer further includes the cabinet for accommodating water phase；The cabinet setting is gone up and down in Z axis
Platform adjusts the cabinet in the height of Z-direction by Z axis hoistable platform；The cabinet is located at below printing head.
The invention also discloses a kind of hanging drop preparation methods of 3D printer, comprising the following steps:
1) material with shear shinning is dissolved into water, obtains transparent water-setting colloidal liquid as water phase, chooses
One or more oily matter mixing are as oily phase；
2) water phase is placed on Z axis hoistable platform, pressure control mechanism is used to provide power oily mutually by printing spray
Head squeezes out；
3) movement of the printing head in X/Y plane is driven by X-axis mobile mechanism, Y-axis moving mechanism, is gone up and down by Z axis
Platform realizes the adjusting of Z-direction distance between region to be printed and printing head, to control the printing spray on 3D printer
The motion profile of head, controls the working condition of pressure control mechanism, so that shearing oil mutually obtains the drop being distributed in water phase.
Preferably, the shear shinning material can be carbomer or xanthan gum.
Preferably, the printing head is a leptosomatic hollow cylinder, and one end is connected with conduit, other end conduct
Nozzle.
Preferably, the printing head motion profile is that printing head first pauses when being moved to a position in water phase,
Then pressure control mechanism squeezes out quantitative oil phase volume, moves again to after waiting quantitative oil phase volume all to squeeze out next
Position.
Preferably, the oily matter can be one of silk oil, cashmere ester or vitamin E or several mixed
It closes.
The invention also discloses the motion tracks by controlling printing head to obtain the specific shape being made of microlayer model
Threedimensional model.
The invention also discloses according to the 3D drop printer and its preparing hanging drop, the drop can be by
Its particle size and spatial position are accurately controlled, uses specific drop spatial arrangement mode can be with largest optimization water phase and oily phase
Proportion.In addition it uses with digital model file as basic 3D printing technique, can prepare according to demand composed of droplets
The threedimensional model of specific shape.
Beneficial effects of the present invention are as follows:
(1) present invention proposes a kind of based on 3D drop printer preparation suspension microlayer model system that this method is simple and easy to do, micro-
Size droplet diameter is uniform controllable, can carry out Precise spraying and control to system.
(2) present invention uses 3D printing technique, can be prepared according to demand by liquid based on digital model file
Drip the suspension microlayer model system with specific three dimensional shape of composition.The system that tradition is prepared by cutting method, drop grain
Diameter is different, dispersion is uneven, position is unordered, easy formation mutually separates.3D drop printing technique can carry out droplet size and position
It is precisely controlled, prepares the hanging drop system of specific structure, be with a wide range of applications in actual production.
(3) system that tradition is prepared by cutting method, can not accurately control dispersion process, easily form phase point
From causing the oily ratio mutually in water phase lower, it is difficult to improve.The present invention proposes that 3D printing prepares suspension microlayer model system, leads to
It crosses and accurately controls the optimal alignment that each droplet position realizes drop, oily phase can be increased substantially in suspension microlayer model system
Ratio reaches as high as 74%.
(4) present invention can be precisely controlled microlayer model size using the printing of 3D drop, optimize oil mutually with the ratio of water phase, beat
Print off the threedimensional model with specific shape being made of oil phase drop.It can develop and design accordingly by choosing corresponding oil mutually
Material product can be developed and the visual cosmetics of design function for example, by using silk oil etc. to the oily phase of skin beneficiating.Example again
Such as oil phase monomer is polymerize to form particle, particle by 3D drop printed design close-packed structure using polymerizable oil phase monomer
Between be connected with each other, the available material model being made of particle.
Detailed description of the invention
Fig. 1 is to utilize the 3D printer preparation suspension microlayer model after repacking.
Fig. 2 is the drop model arranged with simple cubic that preparation is made of suspension microlayer model.
In figure: 1, syringe pump, 2, conduit, 3, printing head, 4, stepper motor, 5, container, 6, aqueous phase solution, 7 serial interfaces
Mouth line.
Fig. 3 is to be prepared with the spherical shape of suspension microlayer model composition and reflect the tapered drop model in quadrangle.
Specific embodiment
It is as follows using method preparation step of the invention referring to attached drawing 1:
With reference to the accompanying drawing 1 and embodiment the present invention will be further described.
A kind of method that hanging drop is prepared the present invention provides 3D printer and its in hydrogel, passes through 3D printer
Control particle size and the spatial position of drop, as shown in Figure 1, the 3D printer by syringe pump 1, conduit 2, printing head 3,
Stepper motor 4, container 5 form.3D printing is a kind of technology based on digital model file, can by digital model file
To control the push-in stroke of printer three-dimensional motion system and syringe pump.Printing head is immersed into hydrogel.Printing head moves
It when moving some position, pauses several seconds, then syringe pump feeds quantitative oil phase volume, and oil mutually forms at printing head micro-
Ball, waiting quantitative oil, mutually all is squeezed out, then moves printing head again, under the action of shear force, obtains being suspended in water-setting
Drop in glue.
It names embodiment and illustrates the present invention, but the present invention is not limited to following embodiments.
Embodiment 1: cylindrical body composed of droplets is prepared.
Hanging drop is prepared using method of the invention, the specific steps are as follows:
(1) circuit that the control consumptive material of traditional fusion sediment formula 3D printer is fed is connected to note by serial line interface
It penetrates on pump control system.The syringe needle that selection internal diameter is 0.33mm, outer diameter 0.63mm, length are 15mm is as printing head, printing
Spray head connect conveying oil phase liquid by PE pipe with syringe pump.
(2) Acritamer 940 is dissolved into water, adjusts pH to 7.Clear hydrogel is obtained as water phase.Select different nonyl
The different nonyl ester of acid is as oily phase.
(3) water phase is held with seed bottle, then seed bottle is placed on Z axis platform.
(4) the 3D printer progress of work is controlled by writing digital model file, obtains the three-dimensional being made of oil phase drop
Cylinder model.
Embodiment 2: the suspension microlayer model system composed of droplets with specific three dimensional shape is prepared.
(1) as described in Example 1,3D drop printer is built, prepares oil phase and water-phase material, water phase is put into beaker
In, then beaker is placed on Z axis platform.
(2) the 3D printer progress of work is controlled by writing digital model file, obtains the three-dimensional being made of oil phase drop
Spherical model and reflect quadrangle Based On The Conic Model (as shown in Figure 3).
Claims (9)
1. a kind of 3D printer for preparing hanging drop, including three-dimensional mobile print system, the mobile print system of the three-dimensional
Including Z axis hoistable platform, X-axis mobile mechanism, Y-axis moving mechanism and printing head, X-axis mobile mechanism, Y-axis moving mechanism are used for
The printing head is driven to realize the movement in X/Y plane；The Z axis hoistable platform is for realizing region to be printed and printing
The adjusting of Z-direction distance between spray head；Characterized by further comprising pressure control mechanisms and conduit；The pressure controls machine
Structure is connected by conduit with printing head.
2. 3D printer according to claim 1, which is characterized in that the pressure control mechanism is syringe pump or wriggling
Pump.
3. 3D printer according to claim 1, it is characterised in that further include the cabinet for accommodating water phase；The case
Body is arranged in Z axis hoistable platform, adjusts the cabinet in the height of Z-direction by Z axis hoistable platform；The cabinet is located at printing
Below spray head.
4. a kind of hanging drop preparation method of 3D printer as described in claim 1, which comprises the following steps:
1) material with shear shinning is dissolved into water, obtains transparent water-setting colloidal liquid as water phase, chooses one kind
Or a variety of oily matter mixing are as oily phase；
2) water phase is placed on Z axis hoistable platform, pressure control mechanism is used to provide power mutually to be squeezed oily by printing head
Out；
3) movement of the printing head in X/Y plane is driven by X-axis mobile mechanism, Y-axis moving mechanism, passes through Z axis hoistable platform
The adjusting of Z-direction distance between region to be printed and printing head is realized, to control the printing head on 3D printer
Motion profile, controls the working condition of pressure control mechanism, so that shearing oil mutually obtains the drop being distributed in water phase.
5. the preparation method according to claim 4, which is characterized in that the shear shinning material can for carbomer or
Xanthan gum.
6. the preparation method according to claim 4, which is characterized in that the printing head is one leptosomatic hollow
Cylinder, one end are connected with conduit, and the other end is as nozzle.
7. the preparation method according to claim 4, which is characterized in that the printing head motion profile is printing head
It first pauses when being moved to a position in water phase, then pressure control mechanism squeezes out quantitative oil phase volume, waits quantitative oil
Phase volume moves again to next position after all squeezing out.
8. the preparation method according to claim 4, which is characterized in that the oily matter can be silk oil, cashmere
One of ester or vitamin E or several mixing.
9. the threedimensional model being prepared according to any one of the claim 4-8 preparation method, it is characterised in that pass through control
The motion track of printing head obtains the threedimensional model for the specific shape being made of microlayer model.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811168233.7A CN109249617B (en) | 2018-10-08 | 2018-10-08 | 3D droplet printer and method for preparing suspension droplets by using same |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811168233.7A CN109249617B (en) | 2018-10-08 | 2018-10-08 | 3D droplet printer and method for preparing suspension droplets by using same |
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| CN109249617A true CN109249617A (en) | 2019-01-22 |
| CN109249617B CN109249617B (en) | 2020-11-17 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111171341A (en) * | 2019-12-31 | 2020-05-19 | 浙江大学 | Janus liquid drop with structural color based on 3D liquid drop printing and preparation method thereof |
| CN113524660A (en) * | 2021-08-10 | 2021-10-22 | 烟台液秀生物科技有限公司 | High-throughput array type 3D liquid drop printing method |
| CN113524674A (en) * | 2021-07-07 | 2021-10-22 | 清华大学深圳国际研究生院 | Device and method for preparing three-dimensional patterned multi-material hydrogel heterostructure |
| CN115042427A (en) * | 2022-06-23 | 2022-09-13 | 浙江大学 | Method for preparing heavy metal isotope marker combination through 3D liquid printing in high flux |
| CN117464993A (en) * | 2023-10-18 | 2024-01-30 | 浙江大学 | Device and method for 3D printing gradient pore macroporous gelatin through multi-nozzle array |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103635252A (en) * | 2011-03-08 | 2014-03-12 | 卡普苏姆公司 | Method for forming drops of a first phase dispersed in a second phase substantially immiscible with the first phase |
| WO2017081040A1 (en) * | 2015-11-09 | 2017-05-18 | University College Dublin, National University Of Ireland, Dublin | A method, system and device for three dimensional additive manufacturing in a liquid phase |
| WO2017210298A1 (en) * | 2016-05-31 | 2017-12-07 | Northwestern University | Method for the fabrication of three-dimensional objects and apparatus for same |
| CN107803504A (en) * | 2016-09-09 | 2018-03-16 | 北京梦之墨科技有限公司 | A kind of suspension printing-forming method of liquid metal three-dimensional macro structure |
| CN108357101A (en) * | 2018-04-08 | 2018-08-03 | 浙江大学 | A kind of environment-friendly type powder 3D printer |
-
2018
- 2018-10-08 CN CN201811168233.7A patent/CN109249617B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103635252A (en) * | 2011-03-08 | 2014-03-12 | 卡普苏姆公司 | Method for forming drops of a first phase dispersed in a second phase substantially immiscible with the first phase |
| WO2017081040A1 (en) * | 2015-11-09 | 2017-05-18 | University College Dublin, National University Of Ireland, Dublin | A method, system and device for three dimensional additive manufacturing in a liquid phase |
| WO2017210298A1 (en) * | 2016-05-31 | 2017-12-07 | Northwestern University | Method for the fabrication of three-dimensional objects and apparatus for same |
| CN107803504A (en) * | 2016-09-09 | 2018-03-16 | 北京梦之墨科技有限公司 | A kind of suspension printing-forming method of liquid metal three-dimensional macro structure |
| CN108357101A (en) * | 2018-04-08 | 2018-08-03 | 浙江大学 | A kind of environment-friendly type powder 3D printer |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111171341A (en) * | 2019-12-31 | 2020-05-19 | 浙江大学 | Janus liquid drop with structural color based on 3D liquid drop printing and preparation method thereof |
| CN113524674A (en) * | 2021-07-07 | 2021-10-22 | 清华大学深圳国际研究生院 | Device and method for preparing three-dimensional patterned multi-material hydrogel heterostructure |
| CN113524674B (en) * | 2021-07-07 | 2022-12-13 | 清华大学深圳国际研究生院 | Device and method for preparing three-dimensional patterned multi-material hydrogel heterostructure |
| CN113524660A (en) * | 2021-08-10 | 2021-10-22 | 烟台液秀生物科技有限公司 | High-throughput array type 3D liquid drop printing method |
| CN113524660B (en) * | 2021-08-10 | 2022-12-13 | 烟台液秀生物科技有限公司 | High-throughput array type 3D liquid drop printing method |
| CN115042427A (en) * | 2022-06-23 | 2022-09-13 | 浙江大学 | Method for preparing heavy metal isotope marker combination through 3D liquid printing in high flux |
| CN117464993A (en) * | 2023-10-18 | 2024-01-30 | 浙江大学 | Device and method for 3D printing gradient pore macroporous gelatin through multi-nozzle array |
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