CN109248335A - It is a kind of to promote the antibacterial tissue surface of a wound, promoting healing gel formula and production technology using terpinene-4-alcohol induced activity minerals - Google Patents
It is a kind of to promote the antibacterial tissue surface of a wound, promoting healing gel formula and production technology using terpinene-4-alcohol induced activity minerals Download PDFInfo
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- CN109248335A CN109248335A CN201710568379.XA CN201710568379A CN109248335A CN 109248335 A CN109248335 A CN 109248335A CN 201710568379 A CN201710568379 A CN 201710568379A CN 109248335 A CN109248335 A CN 109248335A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- General Health & Medical Sciences (AREA)
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Abstract
Promote the antibacterial tissue surface of a wound, promoting healing gel formula and production technology using terpinene-4-alcohol induced activity minerals the invention discloses a kind of, by A, B component difference homogeneous stirring, then after being stirred under vacuum into gel under given conditions, by techniques such as high temperature sterilization disinfections, a kind of well-designed tissue surface of a wound drug delivery device (pre-encapsulated injector) forms gel progress sterile filling.The present invention be directed to organize the surface of a wound to design, formula uniqueness, drug delivery device is novel, and only the offer of the cavity surface of a wound is not good moistens closed healing environment, and anti-infective, promotion growth and reparation, healing time are short；The cavity surface of a wound is not glued after healing, secondary damage is not caused, does not damage cambium, effectively scar is inhibited to be formed；And having good biology performance, this unique formula is applicable to the various surface of a wound and the refractory conjunction surface of a wound of each disease, and the mode of operation of hommization, product softness moisten flexible, free from extraneous odour, and no foreign body sensation is easy to use.
Description
Technical field
The present invention relates to gel technique fields, more particularly to a kind of to utilize tea tree oil extract terpinene -4-
Alcohol-induced active mineral matter promotes the antibacterial tissue surface of a wound, promoting healing gel formula and production technology.
Background technique
Traditional dressing delayed union: it is not able to maintain the surface of a wound and moistens, postpones wound healing；Secondary insult: wound granulation tissue
It is easy in the mesh of long people's dressing, easily damages newborn granulation tissue with wound adhesion and cause pain when more change dressings；
Infection is high: barrier action is poor after dressing infiltration, easily causes exogenous infection；Hemostatic difference: haemostatic effect is poor, and physics compressing stops
Blood；Comfort level is poor: comfort level is undesirable after patient's wrapping；Large labor intensity: course of wound treatment is cumbersome, aggravates medical staff's labor
Fatigue resistance.
New pattern compress (hydrogel, active carbon, chitosan, simple activity material powder) is functional single: such as active carbon class
Dressing is not able to maintain the surface of a wound and moistens, and comfort is insufficient；Silver ion dressing has certain bactericidal effect, and aerogel dressing has certain
Comfort and wettability, but promote healing function insufficient.Chitosan series dressing has certain hemostatic function.It is at high cost: mostly
Concept is propagandized in number new pattern compress patient higher operating costs, market, and it is low that enterprise product Innovation Input lacks quality: market product thousand
Without exception, irregular, or even just can be carried out without clinic and declare registration.
Example (1): Shandong Feng Yuan skin is raw, silicon strong special skin in Shanghai produces product, simple bioactivity glass pulvis, directly
Sieving sterilizing dispenses.
Example (2): Jiangsu Yang Sheng Biotechnology Co., Ltd moral not forestry products, simply by active mineral matter powder (skin
Skin surface of a wound inorganic inducing material) combine medical ventolin packing sterilizing to form paste, hospital gauze is coated into conjunction with paste
Dressing.
Terpinene-4-alcohol is an isolated monomeric substance from narrow leaved tea tree essential oil, is tea tree ethereal oil
Major antibacterial, it is antiviral, hemostasis, wound healing promoting active skull cap components.There are many floristics of the alcohol of -4- containing terpinene,
In tea tree ethereal oil and siliceous, calcium active mineral matter reaction test, the special efficacy of terpinene-4-alcohol is found.Terpinene-4-alcohol
With antifungic action.
Active mineral material, that is, bio-vitric is the amorphous form powder of Inorganic synthese, the native element containing human body
Such as silicon (Si), sodium (Na), calcium (Ca) phosphorus (P) etc. is raw for bone defect healing and the inorganic inducing silicon substrate of wound tissue reparation
Object active material, earliest originate from the U.S., the last century 60's, miserable Vietnam battlefield, due to U.S. army in war because by
Injure tropical rain forest adverse circumstances cause soldier's exanthemv, bone damage and be unable to get and quickly and effectively treat, thus
U.S. government take up to develop it is a kind of can be injured to skin soft tissue effectively again to the novel medicine of the impaired reparation of bone tissue
A special huge sum of money is dialled for developing every year by object, government, and large quantities of scientific research personnel put into research and development ranks, but until the Vietnam War terminates,
This newtype drug is still in development.But American side scientist adheres to studying, and finally in 1971, is put forward for the first time biology by Hench
It is living to develop " while having to soft tissue and bone tissue to repair and bonding action " biology unique in the world at present for active concept
Property material --- bioactivity glass body.Since with good biocompatibility and bioactivity, bioactivity glass causes
The extensive concern of relevant industry, bioactive glass material is as medical instrument in dentistry, orthopaedics bone defect healing and soft
Tissue damage healing is clinically widely used in worldwide, and U.S. FDA, Europe have been obtained in safety and Clinical efficacy
The approval of coenosarc and China National Drug Surveillance Authority is as bone impairment renovation material, and clinic makes bioactivity glass
Use more than ten years.
Therefore, how to provide it is a kind of have specificity, promoting healing, suppression scar, have a wide range of application, operate it is convenient, at low cost
The characteristics of promote that the tissue surface of a wound is antibacterial, promoting healing gel using tea tree oil extract terpinene-4-alcohol induced activity minerals
The problem of formula and processing technology is those skilled in the art's urgent need to resolve.
Summary of the invention
In view of this, the present invention provides a kind of by bioactivity glass combination tea tree ethereal oil extract terpinene-4-alcohol,
By reacting for active mineral matter and terpinene-4-alcohol, promoting healing effect of stimulating activity minerals, this products application is in tissue
The surface of a wound is antibacterial, reduce histocyte diffusate and wound stops blooding and conglutinant utilization tea tree oil extract terpinene-
The alcohol-induced active mineral matter of 4- promotes the antibacterial tissue surface of a wound, promoting healing gel formula and production technology.
To achieve the above object, the invention provides the following technical scheme:
A kind of antibacterial, promoting healing using the tea tree oil extract terpinene-4-alcohol induced activity minerals promotion tissue surface of a wound
Gel formula and production technology, comprising: component A and B component；Wherein, it is 45% that the component A, which accounts for the percentage of gel total weight,
~70%；The percentage that the B component accounts for gel total weight is 30%~55%；It is characterized in that, the component A contains: pine
Oily alkene -4- alcohol 10%-30%, bioactivity glass 1%-10%, medical liquid paraffin 15%-20%, polyethylene glycol 400
2%-15%, albolene 30%-65%；The B component contains: medical glycerine 10%-15%, Sodium Hyaluronate 0.5%-
2.5%, purified water 60%-80%, polyvinyl alcohol 5%-15%, Acritamer 940 0.5%-1%.
Preferably, in a kind of above-mentioned utilization tea tree oil extract terpinene-4-alcohol induced activity minerals promotion tissue wound
Face is antibacterial, in promoting healing gel formula and production technology, specific manufacture craft are as follows: (1) by bioactivity glass in the component A
With 220 DEG C high-temperature process 2 hours, with ball mill grinding to 300 targets it is quasi- after sieving for standby；(2) pine tar will be removed in the component A
Other each raw materials of alkene -4- alcohol dissolve by heating stirring (120 DEG C ± 15 DEG C of temperature), and the bioactivity glass that sieving is then added stirs
It mixes uniformly, is cooled to 55-65 DEG C of addition terpinene-4-alcohol and activity glass, stirs evenly；(3) it will be removed in the B component
Other raw materials of Sodium Hyaluronate dissolve by heating stirring (temperature 95- ± 5 DEG C), are cooled to 45-55 degrees Celsius of addition hyaluronic acid
Sodium continues stirring to room temperature；(4) by component A B component gel according to different proportion together be added vacuum stirring fill in, stirring
It is filling that sterile gel is carried out after uniformly；(5) glass tube of special pre-encapsulated injector is filling at gel, aluminium is filled after push rod is added
Bag is moulded, then uses Co 60 or electron beam irradiation sterilization.
It can be seen via above technical scheme that compared with prior art, the present disclosure provides in one by bioactivity
Glass combination tea tree ethereal oil extract terpinene-4-alcohol passes through reacting for active mineral matter and terpinene -4- alcohol, stimulating activity
Promoting healing effect of minerals, the present invention be applied to the tissue surface of a wound it is antibacterial, reduce histocyte diffusate and wound hemostasis and
Promote Wound healing.And simple bioactive glass powder directly applies to the surface of a wound and be easy to cause excessive, the local pH of stimulation
Rise too fast equal reaction, by way of attached gel, administration is mild, significant in efficacy, can preferable flap coverage, solve powder
Agent is administered in the surface of a wound and is difficult to and stimulates excessive clinical problem.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
The embodiment of the invention discloses one kind have specificity, promoting healing, suppression scar, have a wide range of application, operate it is convenient, at
The antibacterial, promoting healing using the tea tree oil extract terpinene-4-alcohol induced activity minerals promotion tissue surface of a wound of this low feature
Gel formula and production technology.
Please refer to a kind of utilization tea tree oil extract terpinene-4-alcohol induced activity minerals promotion group disclosed by the invention
The antibacterial surface of a wound, promoting healing gel formula and production technology are knitted, is specifically included:
Component A and B component；Wherein, it is 45%~70% that component A, which accounts for the percentage of gel total weight,；B component accounts for gel
The percentage of total weight is 30%~55%；It is characterized in that, component A contains: terpinene-4-alcohol 10%-30%, biology are living
Property glass 1%-10%, medical liquid paraffin 15%-20%, polyethylene glycol 400 2%-15%, albolene 30%-65%；
B component contains: medical glycerine 10%-15%, Sodium Hyaluronate 0.5%-2.5%, purified water 60%-80%, polyvinyl alcohol
5%-15%, Acritamer 940 0.5%-1%.
Promote the tissue surface of a wound using tea tree oil extract terpinene-4-alcohol induced activity minerals the invention discloses a kind of
Then antibacterial, promoting healing gel formula and production technology are stirred under vacuum under given conditions by A, B component difference homogeneous stirring
After gel, by techniques such as high temperature sterilization disinfections, a kind of well-designed tissue surface of a wound drug delivery device (pre-encapsulated injector) will
Gel carries out sterile filling and forms.The present invention be directed to organize the surface of a wound to design, formula is unique, and drug delivery device is novel, not only chamber
Surface of a wound offer in road is good to moisten closed healing environment, and anti-infective, promotion growth and reparation, healing time are short；It is not glued after healing
The cavity surface of a wound does not cause secondary damage, does not damage cambium, effectively scar is inhibited to be formed；And has good biology
Performance, this unique formula is applicable to the various surface of a wound and the refractory conjunction surface of a wound of each disease, and the mode of operation of hommization, product are soft
Soft to moisten flexible, free from extraneous odour, no foreign body sensation is easy to use.
In order to further optimize the above technical scheme, specific manufacture craft are as follows: (1) by bioactivity glass in the component A
Glass with 220 DEG C high-temperature process 2 hours, with ball mill grinding to 300 targets it is quasi- after sieving for standby；(2) pine will be removed in the component A
Other each raw materials of oily alkene -4- alcohol dissolve by heating stirring (120 DEG C ± 15 DEG C of temperature), and the bioactivity glass of sieving is then added
It stirs evenly, is cooled to 55-65 DEG C of addition terpinene-4-alcohol and activity glass, stirs evenly；(3) it will be removed in the B component
Other raw materials of Sodium Hyaluronate dissolve by heating stirring (temperature 95- ± 5 DEG C), are cooled to 45-55 degrees Celsius of addition hyaluronic acid
Sodium continues stirring to room temperature；(4) by component A B component gel according to different proportion together be added vacuum stirring fill in, stirring
It is filling that sterile gel is carried out after uniformly；(5) glass tube of special pre-encapsulated injector is filling at gel, aluminium is filled after push rod is added
Bag is moulded, then uses Co 60 or electron beam irradiation sterilization.
Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with other
The difference of embodiment, the same or similar parts in each embodiment may refer to each other.For device disclosed in embodiment
For, since it is corresponded to the methods disclosed in the examples, so being described relatively simple, related place is said referring to method part
It is bright.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (2)
1. a kind of antibacterial, promoting healing using the tea tree oil extract terpinene-4-alcohol induced activity minerals promotion tissue surface of a wound coagulates
Glue formula and production technology, comprising: component A and B component；Wherein, the component A account for gel total weight percentage be 45%~
70%；The percentage that the B component accounts for gel total weight is 30%~55%；It is characterized in that, the component A contains: pine tar
Alkene -4- alcohol 10%-30%, bioactivity glass 1%-10%, medical liquid paraffin 15%-20%, polyethylene glycol 400 2%-
15%, albolene 30%-65%；The B component contains: medical glycerine 10%-15%, Sodium Hyaluronate 0.5%-2.5%,
Purified water 60%-80%, polyvinyl alcohol 5%-15%, Acritamer 940 0.5%-1%.
2. a kind of utilization tea tree oil extract terpinene-4-alcohol induced activity minerals promotion group according to claim 1
Knit the antibacterial surface of a wound, promoting healing gel formula and production technology, which is characterized in that specific manufacture craft are as follows: (1) by the component A
Middle bioactivity glass with 220 DEG C high-temperature process 2 hours, with ball mill grinding to 300 targets it is quasi- after sieving for standby；(2) by the A
Other each raw materials in component except terpinene-4-alcohol dissolve by heating stirring (120 DEG C ± 15 DEG C of temperature), and the life of sieving is then added
Object activity glass stirs evenly, and is cooled to 55-65 DEG C of addition terpinene-4-alcohol and activity glass, stirs evenly；(3) by institute
It states in B component except other raw materials of Sodium Hyaluronate dissolve by heating stirring (temperature 95- ± 5 DEG C), is cooled to 45-55 degrees Celsius and adds
Sodium Hyaluronate is added to continue stirring to room temperature；(4) by component A the gel of B component vacuum stirring is added together according to different proportion
In filling, it is filling that sterile gel is carried out after mixing evenly；(5) glass tube of special pre-encapsulated injector is filling at gel, it is added
Aluminium plastic bag is filled after push rod, then uses Co 60 or electron beam irradiation sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710568379.XA CN109248335A (en) | 2017-07-13 | 2017-07-13 | It is a kind of to promote the antibacterial tissue surface of a wound, promoting healing gel formula and production technology using terpinene-4-alcohol induced activity minerals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710568379.XA CN109248335A (en) | 2017-07-13 | 2017-07-13 | It is a kind of to promote the antibacterial tissue surface of a wound, promoting healing gel formula and production technology using terpinene-4-alcohol induced activity minerals |
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| Publication Number | Publication Date |
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| CN109248335A true CN109248335A (en) | 2019-01-22 |
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| CN201710568379.XA Pending CN109248335A (en) | 2017-07-13 | 2017-07-13 | It is a kind of to promote the antibacterial tissue surface of a wound, promoting healing gel formula and production technology using terpinene-4-alcohol induced activity minerals |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150030708A1 (en) * | 2009-11-03 | 2015-01-29 | Nutriquine N.V. | Compositions comprising extracts of boswellia, tea tree, aloe and lavender oil and methods of treating wounds, burns and skin injuries therewith |
| CN106039380A (en) * | 2016-06-28 | 2016-10-26 | 邯郸沃伦多科技开发有限公司 | Tissue wound repairing material and related product preparation method thereof |
| CN106344956A (en) * | 2016-08-12 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Chitosan antibacterial gel with effect of promoting healing and method for preparing chitosan antibacterial gel |
| CN106924867A (en) * | 2017-03-29 | 2017-07-07 | 连光 | A kind of bio-vitric dressing and doser for uterine neck surface of a wound promoting healing |
-
2017
- 2017-07-13 CN CN201710568379.XA patent/CN109248335A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150030708A1 (en) * | 2009-11-03 | 2015-01-29 | Nutriquine N.V. | Compositions comprising extracts of boswellia, tea tree, aloe and lavender oil and methods of treating wounds, burns and skin injuries therewith |
| CN106039380A (en) * | 2016-06-28 | 2016-10-26 | 邯郸沃伦多科技开发有限公司 | Tissue wound repairing material and related product preparation method thereof |
| CN106344956A (en) * | 2016-08-12 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Chitosan antibacterial gel with effect of promoting healing and method for preparing chitosan antibacterial gel |
| CN106924867A (en) * | 2017-03-29 | 2017-07-07 | 连光 | A kind of bio-vitric dressing and doser for uterine neck surface of a wound promoting healing |
Non-Patent Citations (1)
| Title |
|---|
| 叶倩等: "奶牛乳房炎防治的研究进展", 《现代畜牧和兽医》 * |
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Application publication date: 20190122 |