CN109248161A - It is a kind of to prepare anti-desensitizing paste formula and processing technology using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium - Google Patents
It is a kind of to prepare anti-desensitizing paste formula and processing technology using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium Download PDFInfo
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- CN109248161A CN109248161A CN201710568378.5A CN201710568378A CN109248161A CN 109248161 A CN109248161 A CN 109248161A CN 201710568378 A CN201710568378 A CN 201710568378A CN 109248161 A CN109248161 A CN 109248161A
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- Prior art keywords
- terpinene
- alcohol
- tea tree
- oil extract
- tree oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
Anti- desensitizing paste formula and processing technology is prepared using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium the invention discloses a kind of, it is characterized in that, each component including following quality point: terpinene-4-alcohol 10%-30%, phosphorus calcium silicates sodium 1%-10%, potassium nitrate 0.01%-0.5%, polyethylene glycol-800 2%-15%, medical glycerine 40%-65%, acetic acid chlorhexidine 0.01%-0.5%, chitosan 0.5%-2.5%, Acritamer 940 0.5%-1.5%, silica 2%-5%, titanium dioxide 0.5%-2%, precipitated calcium carbonate 1%-5%, foaming agent K12 0.5%-2% essence is appropriate, appropriate sweetener.Its preparation process is reacting by active mineral matter and terpinene-4-alcohol, and the prevention of stimulating activity minerals is desensitized effect, this products application is in oral bacteriostasis and prevention desensitization；And simple bioactive glass powder directly applies to canker sore sensitive part and be easy to cause stimulation excessive, and local pH rises too fast equal reaction, and by way of combining narrow leaved tea tree oil extract, it is excessive to solve the problems, such as that pulvis stimulates.
Description
Technical field
The present invention relates to anti-desensitizing paste technical fields, more particularly to a kind of to utilize tea tree oil extract pine tar
Alkene -4- alcohol and phosphoric acid silico-calcium sodium prepare anti-desensitizing paste formula and processing technology.
Background technique
Terpinene-4-alcohol is a monomeric substance isolated in titrol, is titrol
Main bactericidal and insecticidal activity ingredient.There are many floristics containing terpinene-4-alcohol, in titrol and siliceous, calcium work
In property minerals reaction test, the special efficacy of terpinene-4-alcohol is found.Terpinene-4-alcohol has antifungic action.Terpinene
4 alcohol are to be present in one of various plants essential oil monoterpenes compound (at present with dilute 4 alcohol of the pine tar of narrow leaved tea tree oil extract
It is active high, pure natural), it has now been found that 4 alcohol of terpinene has antibechic, antibacterial, anti-mite, anti-inflammatory, anti-oxidant isoreactivity, transported
For treating the diseases such as canalis radicis dentis inflammation, gingivitis, stomatocace, skin infection, tinea of feet and hands.
Phosphoric acid silico-calcium sodium, that is, bio-vitric is the amorphous form powder of Inorganic synthese, such as silicon of the native element containing human body
(Si), sodium (Na), calcium (Ca) phosphorus (P) etc. are living for bone defect healing and the inorganic inducing silicon substrate biology of wound tissue reparation
Property material, earliest originate from the U.S., the last century 60's, miserable Vietnam battlefield, due to U.S. army in war because being injured
The adverse circumstances of tropical rain forest cause soldier's exanthemv, bone damage and be unable to get and quickly and effectively treat, U.S. thus
Government take up to develop it is a kind of can be injured to skin soft tissue effectively again to the newtype drug of the impaired reparation of bone tissue, political affairs
A special huge sum of money is dialled for developing in mansion every year, and large quantities of scientific research personnel put into research and development ranks, but until the Vietnam War terminates, it is this new
Type drug is still in development.But American side scientist adheres to studying, and finally in 1971, it is general to be put forward for the first time bioactivity by Hench
It reads, develops " while having to soft tissue and bone tissue to repair and bonding action " bioactivity material unique in the world at present
Material --- bioactivity glass body.Since with good biocompatibility and bioactivity, bioactivity glass causes phase
The extensive concern of industry is closed, bioactive glass material is as medical instrument in dentistry, orthopaedics bone defect healing and soft tissue
Wound healing is clinically widely used in worldwide, and U.S. FDA, the European Community have been obtained in safety and Clinical efficacy
And the approval of China National Drug Surveillance Authority is as bone impairment renovation material, bioactivity glass through clinical usage ten
For many years.
Dental hypersensitiveness's disease is a kind of subjective symptom caused by the dentine of environmental stimuli exposure, shows as receiving outer
Boundary stimulates the caused aching and limp pain of tooth such as the effects of temperature (hot and cold), chemistry (acid, sweet tea), mechanical (rubbing or sting hard object)
Symptom seriously affects patients diet and physical and mental health.Dental hypersensitiveness belongs to a kind of common disease in cavity section disease, morbidity
Rate is high, clinically treats frequently with the drugs such as YAG Dental Laser Treatment of Dentin or fluoride, strontium chloride, ammonium fluoride silver, silver iodide, but
These drugs respectively have its advantage and disadvantage, and therapeutic effect is not satisfactory, and treated effect is low, maintain effective time short, high recurrence rate,
And these methods are palliative, can only treat, and cannot prevent.
Therefore, it is a kind of good with desensitization effect how to provide, and treated effect is high, maintains effective time long, and have
Antibacterial, bactericidal effect, can prevent the occurrence characteristic of hypersensitive dentin utilizes tea tree oil extract terpinene-4-alcohol and phosphoric acid
Silico-calcium sodium prepares the problem of anti-desensitizing paste formula and processing technology is those skilled in the art's urgent need to resolve.
Summary of the invention
In view of this, the present invention provides one kind to have desensitization effect good, treated effect is high, maintains effective time long,
And there is antibacterial, bactericidal effect, can prevent the occurrence characteristic of hypersensitive dentin utilizes tea tree oil extract terpinene-4-alcohol
And phosphoric acid silico-calcium sodium prepares anti-desensitizing paste formula and processing technology.
To achieve the above object, the invention provides the following technical scheme:
It is a kind of to prepare anti-desensitizing paste formula and production using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium
Technique, which is characterized in that each component including following quality point: terpinene-4-alcohol 10%-30%, phosphorus calcium silicates sodium 1%-
10%, potassium nitrate 0.01%-0.5%, polyethylene glycol-800 2%-15%, medical glycerine 40%-65%, acetic acid chlorhexidine
0.01%-0.5%, chitosan 0.5%-2.5%, Acritamer 940 0.5%-1.5%, silica 2%-5%, titanium dioxide
0.5%-2%, precipitated calcium carbonate 1%-5%, foaming agent K12 0.5%-2% essence is appropriate, appropriate sweetener.
Preferably, a kind of anti-desensitization is prepared using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium above-mentioned
In paste formula and processing technology, specific preparation process are as follows: (1) bioactivity glass is small with 220 DEG C of high-temperature process 2 in component
When, it is crushed to sieving for standby after 800 targets standard；(2) other each raw materials dissolve by heating stirring (temperature 80 in addition to terpinene-4-alcohol
DEG C ± 15 DEG C), the bioactivity glass after sieving is then added stirs evenly, and is cooled to 55-65 DEG C of addition terpinene -4-
Alcohol and activity glass, stir evenly；(3) the lotion paste for preparing step (2), which is added, is stirred under vacuum in filling, and stirring is equal
It is even at gel, be then allowed to stand 24 and as a child carry out sterile filling.
It can be seen via above technical scheme that compared with prior art, the present disclosure provides a kind of related prevention teeth
Desensitization, the preparation of the antibacterial strong tooth product in hemostasis oral cavity are stirred by Multicomponent homogeneous, are then stirred under vacuum under given conditions
After gel, formed by techniques, sterile fillings such as high temperature sterilization disinfections；And it is domestic without a by the mutual leaf of bioactivity glass
Cajeput oil extract terpinene-4-alcohol, by reacting for active mineral matter and terpinene-4-alcohol, stimulating activity minerals
Prevention desensitization effect, this products application is in oral bacteriostasis and prevention desensitization.And simply bioactive glass powder is direct
It is easy to cause stimulation excessive applied to canker sore sensitive part, local pH rises too fast equal reaction, by combining mutual leaf white
It is excessive to solve the problems, such as that pulvis stimulates for the mode of thousand layers of oil extract, whole with good, the treated effect with desensitization effect
Height maintains effective time long, and has antibacterial, bactericidal effect, the characteristics of capable of preventing the generation of hypersensitive dentin.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
The embodiment of the invention discloses one kind to have desensitization effect good, and treated effect is high, maintains effective time long, and
With antibacterial, bactericidal effect, can prevent the occurrence characteristic of hypersensitive dentin using tea tree oil extract terpinene-4-alcohol and
Phosphoric acid silico-calcium sodium prepares anti-desensitizing paste formula and processing technology.
A kind of prepare using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium disclosed by the invention is please referred to prevent
Desensitizing paste formula and processing technology, specifically includes:
The each component of following quality point: terpinene-4-alcohol 10%-30%, phosphorus calcium silicates sodium 1%-10%, potassium nitrate
0.01%-0.5%, polyethylene glycol-800 2%-15%, medical glycerine 40%-65%, acetic acid chlorhexidine 0.01%-0.5%,
It is chitosan 0.5%-2.5%, Acritamer 940 0.5%-1.5%, silica 2%-5%, titanium dioxide 0.5%-2%, light
Matter calcium carbonate 1%-5%, foaming agent K12 0.5%-2% essence is appropriate, appropriate sweetener.
The present invention is a kind of to prepare anti-desensitizing paste formula using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium
And production technology, which is characterized in that each component including following quality point: terpinene-4-alcohol 10%-30%, phosphorus calcium silicates sodium
1%-10%, potassium nitrate 0.01%-0.5%, polyethylene glycol-800 2%-15%, medical glycerine 40%-65%, acetic acid chlorhexidine
0.01%-0.5%, chitosan 0.5%-2.5%, Acritamer 940 0.5%-1.5%, silica 2%-5%, titanium dioxide
0.5%-2%, precipitated calcium carbonate 1%-5%, foaming agent K12 0.5%-2% essence is appropriate, appropriate sweetener.Its preparation process
Reacting by active mineral matter and terpinene-4-alcohol, the prevention of stimulating activity minerals is desensitized effect, this products application in
Oral bacteriostasis and prevention desensitization；And simple bioactive glass powder directly applies to canker sore sensitive part and is easy
Cause to stimulate excessive, the too fast equal reaction of local pH rising, by way of combining narrow leaved tea tree oil extract, solution pulvis
Stimulate excessive problem.
In order to further optimize the above technical scheme, specific preparation process are as follows: (1) bioactivity glass is used in component
220 DEG C high-temperature process 2 hours, be crushed to 800 targets it is quasi- after sieving for standby；(2) other each raw material heating in addition to terpinene-4-alcohol
Dissolution stirring (80 DEG C ± 15 DEG C of temperature), the bioactivity glass after sieving is then added stir evenly, and are cooled to 55-65
DEG C terpinene-4-alcohol and activity glass is added, stirs evenly；(3) vacuum is added in the lotion paste for preparing step (2)
Stirring is stirred into gel, is then allowed to stand 24 and as a child carries out sterile filling in filling.
Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with other
The difference of embodiment, the same or similar parts in each embodiment may refer to each other.For device disclosed in embodiment
For, since it is corresponded to the methods disclosed in the examples, so being described relatively simple, related place is said referring to method part
It is bright.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (2)
1. a kind of prepare anti-desensitizing paste formula and production work using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium
Skill, which is characterized in that each component including following quality point: terpinene-4-alcohol 10%-30%, phosphorus calcium silicates sodium 1%-10%,
Potassium nitrate 0.01%-0.5%, polyethylene glycol-800 2%-15%, medical glycerine 40%-65%, chlorhexidine acetate 0.01%-
0.5%, chitosan 0.5%-2.5%, Acritamer 940 0.5%-1.5%, silica 2%-5%, titanium dioxide 0.5%-
2%, precipitated calcium carbonate 1%-5%, foaming agent K12 0.5%-2% essence is appropriate, appropriate sweetener.
2. a kind of prepared using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium according to claim 1 is prevented
Desensitizing paste formula and processing technology, which is characterized in that specific preparation process are as follows: (1) in component bioactivity glass with 220
DEG C high-temperature process 2 hours, be crushed to 800 targets it is quasi- after sieving for standby；(2) other each raw material heating are molten in addition to terpinene-4-alcohol
Solution stirring (80 DEG C ± 15 DEG C of temperature), the bioactivity glass after sieving is then added stir evenly, and are cooled to 55-65 DEG C
Terpinene-4-alcohol and activity glass is added, stirs evenly；(3) vacuum is added in the lotion paste that step (2) prepares to stir
It mixes in filling, is stirred into gel, be then allowed to stand 24 and as a child carry out sterile filling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710568378.5A CN109248161A (en) | 2017-07-13 | 2017-07-13 | It is a kind of to prepare anti-desensitizing paste formula and processing technology using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710568378.5A CN109248161A (en) | 2017-07-13 | 2017-07-13 | It is a kind of to prepare anti-desensitizing paste formula and processing technology using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109248161A true CN109248161A (en) | 2019-01-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710568378.5A Pending CN109248161A (en) | 2017-07-13 | 2017-07-13 | It is a kind of to prepare anti-desensitizing paste formula and processing technology using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755297A (en) * | 2019-11-26 | 2020-02-07 | 四川艾医生医疗科技有限公司 | High-molecular desensitizing paste and preparation method thereof |
| CN113456822A (en) * | 2021-07-16 | 2021-10-01 | 山东中医药大学附属医院 | Antibacterial and/or desensitizing paste for oral cavity |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070154414A1 (en) * | 2005-12-13 | 2007-07-05 | Bonfiglio Richard P | Antibacterial oral rinse formulation for preventing coronary artery disease |
| CN103449725A (en) * | 2013-08-23 | 2013-12-18 | 四川大学 | Bioactive glass ceramic material and preparation method and application thereof in oral care products |
| CN104983592A (en) * | 2009-04-01 | 2015-10-21 | 高露洁-棕榄公司 | Dual action dentifrice compositions to prevent hypersensitivity and promote remineralization |
| CN106039380A (en) * | 2016-06-28 | 2016-10-26 | 邯郸沃伦多科技开发有限公司 | Tissue wound repairing material and related product preparation method thereof |
-
2017
- 2017-07-13 CN CN201710568378.5A patent/CN109248161A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070154414A1 (en) * | 2005-12-13 | 2007-07-05 | Bonfiglio Richard P | Antibacterial oral rinse formulation for preventing coronary artery disease |
| CN104983592A (en) * | 2009-04-01 | 2015-10-21 | 高露洁-棕榄公司 | Dual action dentifrice compositions to prevent hypersensitivity and promote remineralization |
| CN103449725A (en) * | 2013-08-23 | 2013-12-18 | 四川大学 | Bioactive glass ceramic material and preparation method and application thereof in oral care products |
| CN106039380A (en) * | 2016-06-28 | 2016-10-26 | 邯郸沃伦多科技开发有限公司 | Tissue wound repairing material and related product preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755297A (en) * | 2019-11-26 | 2020-02-07 | 四川艾医生医疗科技有限公司 | High-molecular desensitizing paste and preparation method thereof |
| CN113456822A (en) * | 2021-07-16 | 2021-10-01 | 山东中医药大学附属医院 | Antibacterial and/or desensitizing paste for oral cavity |
| CN113456822B (en) * | 2021-07-16 | 2022-05-27 | 山东中医药大学附属医院 | Antibacterial and/or desensitizing paste for oral cavity |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190122 |
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| RJ01 | Rejection of invention patent application after publication |