CN109238571A - A kind of micro leakage blood monitoring device of blood purification system and method - Google Patents
A kind of micro leakage blood monitoring device of blood purification system and method Download PDFInfo
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- CN109238571A CN109238571A CN201811280460.9A CN201811280460A CN109238571A CN 109238571 A CN109238571 A CN 109238571A CN 201811280460 A CN201811280460 A CN 201811280460A CN 109238571 A CN109238571 A CN 109238571A
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- 239000008280 blood Substances 0.000 title claims abstract description 63
- 210000004369 blood Anatomy 0.000 title claims abstract description 63
- 238000012806 monitoring device Methods 0.000 title claims abstract description 16
- 238000000746 purification Methods 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims abstract description 10
- 239000002699 waste material Substances 0.000 claims abstract description 46
- 239000007788 liquid Substances 0.000 claims abstract description 38
- 239000000725 suspension Substances 0.000 claims abstract description 37
- 238000012360 testing method Methods 0.000 claims abstract description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 21
- 239000000741 silica gel Substances 0.000 claims description 21
- 229910002027 silica gel Inorganic materials 0.000 claims description 21
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 11
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims description 11
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims description 11
- 229920002079 Ellagic acid Polymers 0.000 claims description 11
- 229960002852 ellagic acid Drugs 0.000 claims description 11
- 235000004132 ellagic acid Nutrition 0.000 claims description 11
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims description 11
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 8
- 229910052710 silicon Inorganic materials 0.000 claims description 8
- 239000010703 silicon Substances 0.000 claims description 8
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 7
- 238000012544 monitoring process Methods 0.000 claims description 7
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 230000006870 function Effects 0.000 claims description 6
- 238000001631 haemodialysis Methods 0.000 claims description 6
- 239000012445 acidic reagent Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 230000003321 amplification Effects 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 238000011897 real-time detection Methods 0.000 claims description 3
- 230000009131 signaling function Effects 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims description 3
- 238000004544 sputter deposition Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 4
- 238000000502 dialysis Methods 0.000 description 5
- 239000004411 aluminium Substances 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 206010018873 Haemoconcentration Diseases 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 208000037157 Azotemia Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M3/00—Investigating fluid-tightness of structures
- G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M3/00—Investigating fluid-tightness of structures
- G01M3/40—Investigating fluid-tightness of structures by using electric means, e.g. by observing electric discharges
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
Abstract
The present invention provides a kind of micro leakage blood monitoring device of blood purification system and method, and monitoring device includes cavity, solenoid, temperature control hot plate, microcontroller and driving testing circuit, and wherein solenoid is placed in above cavity, and temperature control hot plate is placed in below cavity；Solenoid realizes driving by control driving testing circuit by microcontroller；Inside cavity is cavity body and sets there are three microchannel that three microchannels are separately connected waste sample feed liquor hose, the first syringe pump, the second syringe pump；Cavity side is equipped with card slot, places ∏ type suspension sensor in card slot, ∏ type suspension sensor output signal is connected to driving testing circuit.The phenomenon that present invention can overcome the problems, such as that the presence in extracorporeal blood purification system in waste liquid due to bubble leads to measurement inaccuracy, can avoid leakage blood false alarm.
Description
Technical field
The invention mainly relates to a kind of haemodialysis, wash mill, micro- more particularly to a kind of extracorporeal blood purification system
The device and method of amount leakage blood monitoring.
Background technique
Artificial kidney, haemodialysis wash mill are widely used in the Diseases such as renal failure, uremia, their principle
It is that will exclude harmful substance superfluous in vivo outside the blood lead body of patient using the principles such as dialysis, filtering, absorption, UF membrane,
Then the blood of purification is led back in vivo again.Artificial kidney, haemodialysis wash mill core be with high molecular material system
At dialysis membrane, this dialysis membrane can replace glomerulus realize the filtering function of its capillary wall, reach the mesh of blood purification
's.If dialysis membrane ruptures in dialysis, washing process, blood can penetrate into waste liquid end, cause blood leakage, to jeopardize
Patient vitals' safety.Therefore, such happen can be avoided by the leakage blood monitoring blood phenomenon of discovery leakage early in time.
Existing leakage blood monitoring method generallys use optical principle to realize, i.e., light emitting diode issues light beam, passes through
Waste fluid container, by the photosensitive sensor or color sensor that are mounted on the waste fluid container other end, (" a kind of blood is net for patent of invention
Change and monitor system with leakage blood " (CN201210257765.4)) optical signal transmissive switched into electric signal, pass through and compares the big of electric signal
It is small to leak blood phenomenon to determine whether existing.
Deep mixed due to ultrafiltrate color, the light intensity signal that light sensor circuit receives different patients is different, adds
The influence of upper photosensitive sensing unit sensitivity response range itself needs the blood in waste liquid when detecting leakage blood with optical principle
Reaching a certain amount of can just be detected by a sensor, and micro, a small amount of leakage blood can not be detected effectively.In addition, traditional optical is former
Influence of the detection method vulnerable to bubble in waste liquid is managed, to influence accuracy of measurement, or even false alarm situation occurs.Discovery in time
The detection of micro, a small amount of leakage blood can judge leakage blood phenomenon in advance, take corresponding safety measure as early as possible.
Summary of the invention
For the deficiency for solving current technology, it is net to provide a kind of blood from practical application for the present invention combination prior art
The micro leakage blood monitoring device of change system and method, can overcome the presence in extracorporeal blood purification system in waste liquid due to bubble to lead
The phenomenon that causing the problem of measurement inaccuracy, can avoid leakage blood false alarm.
Technical scheme is as follows:
A kind of micro leakage blood monitoring device of blood purification system, including cavity, solenoid, temperature control hot plate, microcontroller with
And driving testing circuit, wherein
Solenoid is placed in above cavity, and temperature control hot plate is placed in below cavity；Solenoid passes through control driving by microcontroller
Detection circuit realizes driving；
Inside cavity is cavity body and sets there are three microchannel that three microchannels are separately connected waste sample feed liquor hose, first
Syringe pump, the second syringe pump；Cavity side is equipped with card slot, places ∏ type suspension sensor in card slot, ∏ type suspension sensor is defeated
Signal is connected to driving testing circuit out.
Further, first syringe pump and the second syringe pump are controlled by microcontroller realizes propulsion and post-tensioning function.
Further, the waste liquid sample introduction hose is three port of Y-shaped, two outlet end is separately connected waste fluid bag and chamber
Body is connected between cavity and waste liquid sample introduction hose by the first silica gel hose, passes through the second silicon between cavity and the first syringe pump
The connection of glue hose, is connected between cavity and the second syringe pump by third silica gel hose, the first silica gel hose and waste liquid sample introduction are soft
Pipe junction port is greater than and cavity junction port.
Further, the card slot is made of card slot pedestal and buckle, and ∏ type suspension sensor is fixed by snap in card
On slot bottom seat.
Further, ∏ type suspension sensor, including left cantilever, right cantilever, free vibration end and ∏ type suspension support end；
Left cantilever, right cantilever and free vibration end constitute ∏ type structure；
Two parallel P+ resistance are being carved in support end side, left cantilever, direction is identical as left cantilever longitudinal direction,
Two parallel P+ resistance are connected with highly doped resistance, and draw corresponding electrode；
Two parallel P+ resistance are being carved in support end side, right cantilever, direction is vertical with right cantilever longitudinal direction,
Two parallel P+ resistance are connected with highly doped resistance, and draw corresponding electrode；
Two parallel P+ resistance on left cantilever are mutually perpendicular to two parallel P+ resistance on right cantilever.
Further, substrate used in ∏ type suspension sensor is silicon base, and upper surface deposits silicon face.
Further, there is rectangular-shaped metallic nickel in free vibration end sputtering.
Further, ∏ type suspension sensor cantilever is long: 40~250 μm, wide: 10~50 μm, thick: 1~5 μm.
Further, in driving testing circuit, the corresponding resistance R of left cantilever pressure drags1, the corresponding resistance of right cantilever pressure drag
Rs2With resistance R1、R2、R3、R4, chip IC 2, chip IC 3 form electric bridge；
R in electric bridge1、R2、R3Series connection, and be connected with DC voltage VCC, IC2 chip uses AD835 chip, 1 He of pin
Pin 5 and R3It is connected, pin 8 is connected with D/A chip, and pin 2,4,7 is grounded；
R in electric bridges1、Rs2、R4Series connection, and be connected with DC voltage VCC, IC3 chip uses AD835 chip, 1 He of pin
Pin 5 and R4It is connected, pin 8 is connected with D/A chip, and pin 2,4,7 is grounded；
Bridge output voltage V1、V2Amplified by differential operational amplifier IC1, amplified output voltage is VIC1=A
(V1-V2), A is 1 amplification factor of chip IC；
Microcontroller acquires IC1 output signal V by A/D converterIC1, according to VIC1Value adjusts D/A value and draws to control IC2
The voltage V of foot 8c1With the voltage V of IC3 pin 8c2；
R3With circuit equivalent resistance R composed by chip IC 2ctl1It may be expressed as:
Rctl1=R3/(1-Vc1) (3)
R4With circuit equivalent resistance R composed by chip IC 2ctl2It may be expressed as:
Rctl2=R4/(1-Vc2) (4)
Work as VIC1When value is non-zero, the voltage V of IC2 pin 8 is adjustedc1With the voltage V of IC3 pin 8c2Change equivalent resistance Rctl1
And Rctl2, until VIC1It is 0, reaches bridge balance；
After bridge balance, specific amplitude, the sinusoidal signal of frequency are sent into exchange perseverance by microcontroller control signals generator
Stream source and locking phase amplifying circuit；
Solenoid excited target signal function generates alternating magnetic field, and the metallic nickel of ∏ type suspension sensor free vibration end is handed over
Varying magnetic field influences to generate the effect of power, to make the vibration deformation of left cantilever, right cantilever generating period, and then makes resistance Rs1With
Resistance Rs2It changes；
After the faint variable signal that electric bridge generates is amplified by difference amplifier IC1, measured by locking phase amplifying circuit
And it is sent into microcontroller.
10, the micro leakage blood monitoring method of a kind of blood purification system, includes the following steps,
Step 1. presses 1:1 proportions ellagic acid reagent+0.025mol/L calcium chloride solution, and in 37 DEG C of water-bath pre-temperatures,
Proportion solution is packed into the first ejection of syringe pump syringe；
Step 2. opens temperature control hot plate, and temperature is made to maintain 37 DEG C；
Step 3. opens the second syringe pump, and the second injection pump work makes waste liquid from the first silica gel hose stream in " drawing " mode
Enter in cavity and finally flow into the second syringe pump, syringe volume used in the second syringe pump is produced depending on a haemodialysis
Raw waste liquid amount determines；
First syringe pump of step 4. starts to inject ellagic acid+0.025mol/L calcium chloride solution proportion reagent, stream to cavity
The second syringe pump is flowed into after 1~5uL/s of speed, waste liquid and the proportion reagent mixing of ellagic acid+0.025mol/L calcium chloride solution；
After step 5. driving testing circuit adjusting automatic bridge reaches balance, pumping signal is issued to solenoid, drives ∏
Type suspension sensor work freely vibrates up and down, and the small-signal that real-time detection electric bridge generates,
Step 6. by measuring bridge export vibration signal amplitude, and according in waste liquid blood content and electric bridge export
The proportionate relationship of vibration signal amplitude can converse the blood content in waste liquid.
Beneficial effects of the present invention:
The present invention overcomes the presence in waste liquid due to bubble to lead to measurement inaccuracy, can avoid showing for leakage blood false alarm
As；The ∏ type suspension sensor structure of micro-nano-scale designs advantages of simple, micro blood and ellagic acid reagent+0.025mol/L
After calcium chloride solution mixing, blood clotting is generated, that is, the bridge signal output that may make ∏ type suspension sensor to constitute changes
Become, the detection of micro blood can be realized；∏ type suspension sensor is but also widely used for other than micro blood detection can be achieved
The small Molecular Detection in the fields such as biology, medicine, chemistry；Bridge electric balanced circuit can be widely applied to any other sensor
The bridge balance of composition is adjusted.
Detailed description of the invention
Attached drawing 1 is ∏ type suspension sensor schematic.
Attached drawing 2 is ∏ type suspension sensors sides figure.
Attached drawing 3 is micro leakage blood monitoring device figure.
Attached drawing 4 is ∏ type suspension sensor fixed slot schematic diagram.
Attached drawing 5 is micro leakage blood monitoring driving detection circuit schematic diagram.
Specific embodiment
With reference to the drawings and specific embodiments, the invention will be further described.It should be understood that these embodiments are merely to illustrate
The present invention rather than limit the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, this field
Technical staff can make various changes or modifications the present invention, and such equivalent forms equally fall within range defined herein.
It based on the micro leakage blood monitoring device of ∏ type suspension sensor include: waste liquid sample introduction hose as shown in figure 3, of the invention
1, the first silica gel hose 2, waste fluid bag 3, the first syringe pump 4, the second silica gel hose 5, temperature control hot plate 6, cavity 7, solenoid 8, card
Slot 9, third silica gel hose 10, the second syringe pump 11, microcontroller 12, driving testing circuit 13.
Wherein waste liquid sample introduction hose 1 is three port of Y-shaped, and waste liquid separately flows into waste fluid bag 3 and the first silica gel hose 2, the
One silica gel hose 2 connects waste liquid sample introduction hose 1 and cavity 7 and 1 junction port of waste liquid sample introduction hose is larger and cavity 7 connects
It is smaller to locate port.
First syringe pump 4 is connect by the second silica gel hose 5 with cavity 7, and the second syringe pump 11 passes through third silica gel hose
10 connect with cavity 7.
Be cavity body inside cavity 7, and there are three microchannel, respectively with the first silica gel hose 2, the second silica gel hose 5, the
The connection of three silica gel hoses 10.Solenoid 8 is placed right above cavity 7, temperature control hot plate 6 is close in underface, and positive side has a rectangle to open
Mouthful, it is the insert port of card slot 9.
∏ type suspension sensor is placed in card slot 9, ∏ type suspension sensor output signal is connected to driving testing circuit 13.
Solenoid 8 realizes driving by control driving testing circuit 13 by microcontroller 12.
First syringe pump 4 and the second syringe pump 11 are controlled by microcontroller 12 realizes propulsion and post-tensioning function.
As shown in Figure 1, in the present invention, ∏ type suspension sensor includes left cantilever 25, right cantilever 27, free vibration end
26, ∏ type suspension support ends 22, substrate used are silicon base, and left cantilever 25, right cantilever 27 and free vibration end 26 constitute ∏ type
Structure, close to 22 side of support end, left cantilever is carved with two parallel P+ resistance 24, direction and left 25 longitudinal direction side of cantilever on 25
To identical, two parallel P+ resistance 24 are connected with highly doped resistance 23, and are connected with aluminium electrode 21,212.Close to support end
Two parallel P+ resistance 28 are carved on right cantilever 27 in 22 sides, and direction is vertical with right 27 longitudinal direction of cantilever, two parallel P+
Resistance 28 is connected with highly doped resistance 29, and is connected with aluminium electrode 210,211, the parallel P+ resistance of two on left cantilever 25, and 24
It is mutually perpendicular to two parallel P+ resistance 28 on right cantilever 27.
As shown in Fig. 2, having rectangular-shaped metallic nickel 214 in the sputtering of free vibration end 26.
Silicon face 213 is deposited on the type suspension surface ∏, silicon face 213 is used to prevent from occurring in a liquid short circuit existing
As.
∏ type suspension sensor, size range are as follows: its arm length: 40~250 μm, wide: 10~50 μm, thick: 1~5 μm.
As shown in figure 4, card slot 9 is made of card slot pedestal 14 and buckle 15, ∏ type suspension sensor is fixed by buckle 15
On card slot pedestal 14, Fast Installation is realized.
Aluminium electrode 21,210,211,212 is connect by the extraction of conducting wire 16 with external circuitry.
As shown in figure 5, the resistance R between aluminium electrode 21 and 212s1, resistance R between 210 and 211s2With resistance R1、R2、
R3、R4, chip IC 2, chip IC 3 form electric bridge, chip IC 2, IC3 are AD835 or similar chip, R in electric bridge3、R4, chip IC 2
It is to realize the Automatic Balance Regulation of electric bridge with 3 major function of chip IC.
R in electric bridge1、R2、R3Series connection, and is connected with DC voltage VCC, IC2 pin 1 and pin 5 and R3Be connected, pin 8 with
D/A chip is connected, and pin 2,4,7 is grounded.
R in electric bridges1、Rs2、R4Series connection, and is connected with DC voltage VCC, IC3 pin 1 and pin 5 and R4It is connected, pin 8
It is connected with D/A chip, pin 2,4,7 is grounded.
Bridge output voltage V1、V2Amplified by differential operational amplifier IC1, amplified output voltage is VIC1=A
(V1-V2), A is 1 amplification factor of chip IC.
Microcontroller 12 acquires IC1 output signal V by A/D converterIC1, according to VIC1Value adjusts D/A value to control IC2
The voltage V of pin 8c1With the voltage V of IC3 pin 8c2。
R3With circuit equivalent resistance R composed by chip IC 2ctl1It may be expressed as:
Rctl1=R3/(1-Vc1) (5)
R4With circuit equivalent resistance R composed by chip IC 2ctl2It may be expressed as:
Rctl2=R4/(1-Vc2) (6)
Work as VIC1When value is non-zero, the voltage V of IC2 pin 8 is adjustedc1With the voltage V of IC3 pin 8c2Change equivalent resistance Rctl1
And Rctl2, until VIC1It is 0, reaches bridge balance.
After bridge balance, specific amplitude, the sinusoidal signal of frequency are sent into and are handed over by 12 control signal generator S1 of microcontroller
Flow constant-current source C1 and locking phase amplifying circuit 1.
8 excited target signal function of solenoid generates alternating magnetic field, the metallic nickel of ∏ type suspension sensor free vibration end 26
214 are influenced to generate the effect of power by alternating magnetic field, thus make the vibration deformation of left cantilever 25,27 generating period of right cantilever, electricity
Resistance Rs1 and resistance Rs2 changes.
After the faint variable signal that electric bridge generates is amplified by difference amplifier IC1, measured by locking phase amplifying circuit 1
And it is sent into microcontroller 12.
Monitoring method based on above-mentioned monitoring device of the invention, includes the following steps:
1. pressing 1:1 proportions ellagic acid reagent+0.025mol/L calcium chloride solution, and in 37 DEG C of water-bath pre-temperatures, will match
It is packed into 4 injection needle tube of the first syringe pump than solution；
2. opening temperature control hot plate 6, temperature is made to maintain 37 DEG C；
3. opening the second syringe pump 11, the second syringe pump 11 works in " drawing " mode, flows waste liquid from the first silica gel hose 2
Enter in cavity 7 and finally flow into the second syringe pump 11, the main function of the second syringe pump 11 is to prevent hemodialysis system from generating
Insufficient pressure so that waste liquid is by the first silica gel hose 2, syringe volume used in the second syringe pump 11 regards a blood
Waste liquid amount caused by dialysing determines；
4. the first syringe pump 4 starts to inject ellagic acid+0.025mol/L calcium chloride solution proportion reagent, flow velocity 1 to cavity 7
The second syringe pump 11 is flowed into after~5uL/s, waste liquid and the proportion reagent mixing of ellagic acid+0.025mol/L calcium chloride solution；
5. issuing pumping signal after the adjusting automatic bridge of driving testing circuit 13 reaches balance to solenoid 8, driving ∏ type
Suspension sensor work freely vibrates up and down, and the small-signal that real-time detection electric bridge generates；
When waste liquid is free of blood, the frequency and amplitude of electric bridge output vibration signal are basicly stable.When waste liquid when containing blood,
After micro blood and the mixing of ellagic acid reagent+0.025mol/L calcium chloride solution, blood clotting phenomenon is generated, to keep electric bridge defeated
The frequency of vibration signal shifts out, and amplitude also becomes smaller.Waste liquid is bigger containing haemoconcentration, and electric bridge exports the amplitude of vibration signal
It is smaller.The positive inverse ratio of amplitude of haemoconcentration and electric bridge output vibration signal i.e. in waste liquid.
6. by measuring bridge export vibration signal amplitude, and according in waste liquid blood content and electric bridge output vibration
The proportionate relationship of signal amplitude can converse the blood content in waste liquid.
Claims (10)
1. a kind of micro leakage blood monitoring device of blood purification system, it is characterised in that: including cavity, solenoid, temperature control hot plate, micro-
Controller and driving testing circuit, wherein
Solenoid is placed in above cavity, and temperature control hot plate is placed in below cavity；Solenoid passes through control driving detection by microcontroller
Circuit realizes driving；
Inside cavity is cavity body and sets there are three microchannel that three microchannels are separately connected waste sample feed liquor hose, the first injection
Pump, the second syringe pump；Cavity side is equipped with card slot, and ∏ type suspension sensor, ∏ type suspension sensor output letter are placed in card slot
Number it is connected to driving testing circuit.
2. a kind of micro leakage blood monitoring device of blood purification system as described in claim 1, it is characterised in that: first note
It penetrates pump and the second syringe pump and realization propulsion and post-tensioning function is controlled by microcontroller.
3. a kind of micro leakage blood monitoring device of blood purification system as described in claim 1, it is characterised in that: the waste liquid into
Sample hose is three port of Y-shaped, two outlet end is separately connected waste fluid bag and cavity, is led between cavity and waste liquid sample introduction hose
The connection of the first silica gel hose is crossed, is connected between cavity and the first syringe pump by the second silica gel hose, cavity and the second syringe pump
Between connected by third silica gel hose, the first silica gel hose and waste liquid sample introduction hose junction port are greater than and cavity junction
Port.
4. a kind of micro leakage blood monitoring device of blood purification system as described in claim 1, it is characterised in that: the card slot by
Card slot pedestal and buckle composition, ∏ type suspension sensor are fixed by snap on card slot pedestal.
5. a kind of micro leakage blood monitoring device of blood purification system as described in claim 1, it is characterised in that: the ∏ type is outstanding
Piece sensor includes left cantilever, right cantilever, free vibration end and ∏ type suspension support end；
Left cantilever, right cantilever and free vibration end constitute ∏ type structure；
Two parallel P+ resistance are being carved in support end side, left cantilever, direction is identical as left cantilever longitudinal direction, and two
Parallel P+ resistance is connected with highly doped resistance, and draws corresponding electrode；
Two parallel P+ resistance are being carved in support end side, right cantilever, direction is vertical with right cantilever longitudinal direction, and two
Parallel P+ resistance is connected with highly doped resistance, and draws corresponding electrode；
Two parallel P+ resistance on left cantilever are mutually perpendicular to two parallel P+ resistance on right cantilever.
6. ∏ type suspension sensor as claimed in claim 5, it is characterised in that: substrate used in ∏ type suspension sensor is silicon substrate
Bottom, upper surface deposit silicon face.
7. ∏ type suspension sensor as claimed in claim 5, it is characterised in that: have rectangular-shaped metal in free vibration end sputtering
Nickel.
8. ∏ type suspension sensor as claimed in claim 5, it is characterised in that: ∏ type suspension sensor cantilever is long: 40~250
μm, it is wide: 10~50 μm, thick: 1~5 μm.
9. a kind of micro leakage blood monitoring device of blood purification system as claimed in claim 5, it is characterised in that:
In driving testing circuit, the corresponding resistance R of left cantilever pressure drags1, the corresponding resistance R of right cantilever pressure drags2With resistance R1、R2、
R3、R4, chip IC 2, chip IC 3 form electric bridge；
R in electric bridge1、R2、R3Series connection, and be connected with DC voltage VCC, IC2 chip uses AD835 chip, pin 1 and pin 5
With R3It is connected, pin 8 is connected with D/A chip, and pin 2,4,7 is grounded；
R in electric bridges1、Rs2、R4Series connection, and be connected with DC voltage VCC, IC3 chip uses AD835 chip, pin 1 and pin
5 and R4It is connected, pin 8 is connected with D/A chip, and pin 2,4,7 is grounded；
Bridge output voltage V1、V2Amplified by differential operational amplifier IC1, amplified output voltage is VIC1=A (V1-V2),
A is 1 amplification factor of chip IC；
Microcontroller acquires IC1 output signal V by A/D converterIC1, according to VIC1Value adjusts D/A value to control IC2 pin 8
Voltage Vc1With the voltage V of IC3 pin 8c2；
R3With circuit equivalent resistance R composed by chip IC 2ctl1It may be expressed as:
Rctl1=R3/(1-Vc1) (1)
R4With circuit equivalent resistance R composed by chip IC 2ctl2It may be expressed as:
Rctl2=R4/(1-Vc2) (2)
Work as VIC1When value is non-zero, the voltage V of IC2 pin 8 is adjustedc1With the voltage V of IC3 pin 8c2Change equivalent resistance Rctl1With
Rctl2, until VIC1It is 0, reaches bridge balance；
After bridge balance, specific amplitude, the sinusoidal signal of frequency are sent into AC constant-current source by microcontroller control signals generator
With locking phase amplifying circuit；
Solenoid excited target signal function generates alternating magnetic field, and the metallic nickel of ∏ type suspension sensor free vibration end is by alternation magnetic
Field influences to generate the effect of power, to make the vibration deformation of left cantilever, right cantilever generating period, and then makes resistance Rs1And resistance
Rs2It changes；
After the faint variable signal that electric bridge generates is amplified by difference amplifier IC1, is measured and sent by locking phase amplifying circuit
Enter microcontroller.
10. a kind of monitoring method using any one of claim 1~9 monitoring device, it is characterised in that: including walking as follows
Suddenly,
Step 1. presses 1:1 proportions ellagic acid reagent+0.025mol/L calcium chloride solution, and in 37 DEG C of water-bath pre-temperatures, will match
It is packed into the first ejection of syringe pump syringe than solution；
Step 2. opens temperature control hot plate, and temperature is made to maintain 37 DEG C；
Step 3. opens the second syringe pump, and the second injection pump work makes waste liquid flow into chamber from the first silica gel hose in " drawing " mode
In vivo and the second syringe pump is finally flowed into, syringe volume used in the second syringe pump regards caused by a haemodialysis
Waste liquid amount determines；
First syringe pump of step 4. to cavity start inject ellagic acid+0.025mol/L calcium chloride solution proportion reagent, flow velocity 1~
The second syringe pump is flowed into after 5uL/s, waste liquid and the proportion reagent mixing of ellagic acid+0.025mol/L calcium chloride solution；
After step 5. driving testing circuit adjusting automatic bridge reaches balance, pumping signal is issued to solenoid, driving ∏ type is outstanding
Piece sensor work freely vibrates up and down, and the small-signal that real-time detection electric bridge generates,
Step 6. by measuring bridge export vibration signal amplitude, and according in waste liquid blood content and electric bridge output vibration
The proportionate relationship of signal amplitude can converse the blood content in waste liquid.
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Application publication date: 20190118 Assignee: Ningbo Maofeng Machinery Engineering Co.,Ltd. Assignor: ZHEJIANG NORMAL University Contract record no.: X2024980000663 Denomination of invention: A device and method for monitoring trace blood leakage in a blood purification system Granted publication date: 20200623 License type: Common License Record date: 20240115 |
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