CN109223715A - A kind of compound fritillaria dissipates the health type preparation method of breaking-wall cell powder - Google Patents

A kind of compound fritillaria dissipates the health type preparation method of breaking-wall cell powder Download PDF

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CN109223715A
CN109223715A CN201811362839.4A CN201811362839A CN109223715A CN 109223715 A CN109223715 A CN 109223715A CN 201811362839 A CN201811362839 A CN 201811362839A CN 109223715 A CN109223715 A CN 109223715A
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breaking
fritillaria
compound
powder
wall cell
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杨连威
王瑞杰
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Northeastern University China
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting

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Abstract

The invention belongs to drug preparation technique fields, are related to a kind of health type preparation method of scattered breaking-wall cell powder of compound fritillaria.The preparation method is divided into dry, coarse crushing and breaking-wall cell crushes three key steps.Drying process appropriate is carried out to each medicinal material that compound fritillaria Bales Off contains first, according to the proportion, by semen armeniacae amarae, bulbus fritillariae cirrhosae and gypsum mix and carry out coarse crushing, then by compound fritillaria dissipate in other medicinal materials carry out coarse crushing, finally the medicinal material powder after above-mentioned all coarse crushings is sufficiently mixed, progress low temperature breaking-wall cell crushing in vibromill is added to after mixing, prepare the compound fritillaria loose powder body of 100% breaking-wall cell, the average particle size of the powder is 7-10 μm, heavy metal without the harm health such as chromium, also ensure that the active principle of preparation process Chinese medicine neither loses simultaneously, also it never degenerates.The compound fritillaria that the present invention prepares dissipates breaking-wall cell powder and is free of any additive, while preparation process is simple, pollution-free in preparation process, and cost is relatively low.

Description

A kind of compound fritillaria dissipates the health type preparation method of breaking-wall cell powder
Technical field
The invention belongs to drug preparation technique fields, are related to a kind of health type preparation of scattered breaking-wall cell powder of compound fritillaria Method.
Background technique
Compound fritillaria, which dissipates, has clearing heat and eliminating phlegm, and relieving cough and asthma effect is used for cough with lung heat, the improvement for the diseases such as wheeze. It has containing eight taste medicinal materials (fritillary bulb, semen armeniacae amarae (stir-fry), Chinese ephedra, borax, the tuber of stemona (honey toast), Radix Glycyrrhizae, Exocarpium Citri Grandis, gypsum) Certain ratio requirement (mass ratio 5:15:10:7:5:15:5:5).The scattered grain of the compound fritillaria of traditional breaking method preparation Degree is 75-150 μm (100-150 mesh), and the non-broken wall of cell due to being not carried out Chinese medicine, drug effect is poor, in order to improve Its curative effect and quick-acting, it is therefore desirable to which breaking-wall cell processing is carried out to the medicinal material that compound fritillaria dissipates.But the bitter apricot during compound fritillaria is scattered Benevolence belongs to oiliness medicinal material, is heated and reunites, it is difficult to realize breaking-wall cell.In addition, the fiber content in Chinese ephedra and Radix Glycyrrhizae is very high, break Wall low efficiency.Although liquid nitrogen frozen crushing can be used in above-mentioned medicinal material, higher cost limits its development and utilization.
Compound fritillaria, which dissipates, at present uses tradition machinery method pulverization process, not only low efficiency, but also the granularity of powder is big, and powder Body reaches far away breaking-wall cell, therefore not only affects curative effect, but also expends a large amount of raw material.In addition, common vibromill The harmful heavy metal contents such as chromium are exceeded in the powder that equipment is prepared, therefore are unfavorable for health.Therefore need to research and develop a kind of safety The compound fritillaria of health dissipates breaking-wall cell powder preparation method.
Summary of the invention
In order to overcome problems of the prior art, the present invention provides a kind of compound fritillarias to dissipate breaking-wall cell powder Health type preparation method.
The specific technical proposal is:
A kind of compound fritillaria dissipates the health type preparation method of breaking-wall cell powder, includes the following steps:
(1) dry: medicinal material needed for being dissipated compound fritillaria with microwave dryer, which is placed in microwave drying oven, is dried place Reason；
(2) semen armeniacae amarae, bulbus fritillariae cirrhosae and gypsum that compound fritillaria dissipates after middle drying are mixed according to ratio as defined in prescription first After conjunction, coarse crushing is carried out, granularity is 80~100 mesh；Secondly by compound fritillaria dissipate in other components compare according to as defined in prescription After example mixing, coarse crushing is carried out, granularity is 100~120 mesh；
(3) the mixed breaking-wall cell that is added in vibromill of all coarse powder broken materials that step (2) obtain is crushed 20 ~40min obtains compound fritillaria and dissipates cell powder, and average particle size is 7~10 μm.
Further, drying temperature described in above-mentioned steps (1) is 50~80 DEG C, and the dry time is 2~4h.
Further, the mechanical crushing equipment that coarse crushing uses in above-mentioned steps (2) is impact grinder, breaking method For dry method, grinding time is 2~6min.
Further, the pulverizing chamber material of vibromill is zirconium oxide in above-mentioned steps (3), and the material of grinding rod is zirconium oxide Or silicon carbide.
Further, breaking-wall cell breaking method is dry method in above-mentioned steps (3), and crushing temperature is -15 DEG C~-30 DEG C, Grinding time is 10~30min.
Beneficial effects of the present invention are that the preparation method can not only realize the breaking-wall cell of all Chinese medicines, Er Qie Do not draw the heavy metal harmful to health such as chromium during broken wall, while also ensuring that the active principle of medicinal material neither loses, it is also constant Matter.
Specific embodiment
Embodiment one:
(1) dry: above-mentioned medicinal material being placed in microwave drying oven dry 4h, drying temperature 50 with microwave dryer ℃。
(2) coarse crushing: the regulation ratio requirement of prescription is dissipated according to compound fritillaria first, accurately weighs dried hardship Almond 50g, bulbus fritillariae cirrhosae 150g and gypsum 100g, are put into impact grinder after mixing and carry out coarse crushing, make the powder of coarse crushing Body granularity is 50 mesh, and resulting mixed powder is labeled as powder A；
Then still according to compound fritillaria dissipate in each medicinal material regulation match, the dried Chinese ephedra 70g of precise, toast hundred Portion 50g, borax 150g, Exocarpium Citri Grandis 50g, Radix Glycyrrhizae 50g, are put into impact grinder after being sufficiently mixed and carry out coarse crushing, make thick The powder granularity of crushing is 80 mesh, and resulting mixed powder is labeled as powder B.
(3) it breaking-wall cell: after above-mentioned gained powder A and B are sufficiently mixed, are added in vibromill, reduce the temperature to zero It is ground after lower 20 DEG C to reach breaking-wall cell, it is broken can to obtain the scattered cell of compound fritillaria by grinding time 20min Wall powder, average particle size are about 9 μm.
Embodiment two:
(1) dry: above-mentioned medicinal material being placed in microwave drying oven dry 3h, drying temperature 60 with microwave dryer ℃。
(2) coarse crushing: the regulation ratio requirement of prescription is dissipated according to compound fritillaria first, accurately weighs dried hardship Almond 50g, bulbus fritillariae cirrhosae 150g and gypsum 100g, are put into impact grinder after mixing and carry out coarse crushing, after making coarse crushing Powder granularity is 60 mesh, and resulting mixed powder is labeled as powder A；
Then still according to compound fritillaria dissipate in each medicinal material regulation match, the dried Chinese ephedra 70g of precise, toast hundred Portion 50g, borax 150g, Exocarpium Citri Grandis 50g, Radix Glycyrrhizae 50g, are put into impact grinder after being sufficiently mixed and carry out coarse crushing, make thick The powder granularity of crushing is 90 mesh, and resulting mixed powder is labeled as powder B.
(3) it breaking-wall cell: after above-mentioned gained powder A and B are sufficiently mixed, are added in vibromill, reduce the temperature to zero It is ground after lower 15 DEG C to reach breaking-wall cell, it is broken can to obtain the scattered cell of compound fritillaria by grinding time 25min Wall powder, average particle size are about 10 μm.
Embodiment three:
(1) dry: above-mentioned medicinal material being placed in microwave drying oven dry 2h, drying temperature 80 with microwave dryer ℃。
(2) coarse crushing: the regulation ratio requirement of prescription is dissipated according to compound fritillaria first, accurately weighs dried hardship Almond 50g, bulbus fritillariae cirrhosae 150g and gypsum 100g, are put into impact grinder after mixing and carry out coarse crushing, make the powder of coarse crushing Body granularity is 80 mesh, and resulting mixed powder is labeled as powder A；
Then still according to compound fritillaria dissipate in each medicinal material regulation match, the dried Chinese ephedra 70g of precise, toast hundred Portion 50g, borax 150g, Exocarpium Citri Grandis 50g, Radix Glycyrrhizae 50g, are put into impact grinder after being sufficiently mixed and carry out coarse crushing, make thick The powder granularity of crushing is 100 mesh, and resulting mixed powder is labeled as powder B.
(3) it breaking-wall cell: after above-mentioned gained powder A and B are sufficiently mixed, are added in vibromill, reduce the temperature to zero It is ground after lower 30 DEG C to reach breaking-wall cell, it is broken can to obtain the scattered cell of compound fritillaria by grinding time 30min Wall powder, average particle size are 7 μm.
Example IV:
(1) dry: above-mentioned medicinal material being placed in microwave drying oven dry 2.5h, drying temperature 70 with microwave dryer ℃。
(2) coarse crushing: the regulation ratio requirement of prescription is dissipated according to compound fritillaria first, accurately weighs dried hardship Almond 50g, bulbus fritillariae cirrhosae 150g and gypsum 100g, are put into impact grinder after mixing and carry out coarse crushing, make the powder of coarse crushing Body granularity is 80 mesh, and resulting mixed powder is labeled as powder A；
Then still according to compound fritillaria dissipate in each medicinal material regulation match, the dried Chinese ephedra 70g of precise, toast hundred Portion 50g, borax 150g, Exocarpium Citri Grandis 50g, Radix Glycyrrhizae 50g, are put into impact grinder after being sufficiently mixed and carry out coarse crushing, make thick The powder granularity of crushing is 90 mesh, and resulting mixed powder is labeled as powder B.
(3) it breaking-wall cell: after above-mentioned gained powder A and B are sufficiently mixed, are added in vibromill, reduce the temperature to zero It is ground after lower 26 DEG C to reach breaking-wall cell, it is broken can to obtain the scattered cell of compound fritillaria by grinding time 20min Wall powder, average particle size are 8 μm.

Claims (8)

1. the health type preparation method that a kind of compound fritillaria dissipates breaking-wall cell powder, which comprises the steps of:
(1) dry: medicinal material needed for being dissipated compound fritillaria with microwave dryer, which is placed in microwave drying oven, to be dried；
(2) after compound fritillaria being dissipated semen armeniacae amarae, bulbus fritillariae cirrhosae and gypsum after middle drying according to the mixing of ratio as defined in prescription first, Coarse crushing is carried out, granularity is 80~100 mesh；Secondly by compound fritillaria dissipate in other components mixed according to ratio as defined in prescription Afterwards, coarse crushing is carried out, granularity is 100~120 mesh；
(3) by all coarse powder broken materials that step (2) obtain it is mixed be added in vibromill breaking-wall cell crush 20~ 40min obtains compound fritillaria and dissipates cell powder, and average particle size is 7~10 μm.
2. method according to claim 1, which is characterized in that drying temperature described in step (1) is 50~80 DEG C, dry Time be 2~4h.
3. method according to claim 1 or claim 2, which is characterized in that the mechanical crushing equipment that coarse crushing uses in step (2) is Impact grinder, breaking method are dry method, and grinding time is 2~6min.
4. method according to claim 1 or claim 2, which is characterized in that the pulverizing chamber material of vibromill is oxidation in step (3) Zirconium, the material of grinding rod are zirconium oxide or silicon carbide.
5. method according to claim 3, which is characterized in that the pulverizing chamber material of vibromill is zirconium oxide in step (3), is ground The material of frotton is zirconium oxide or silicon carbide.
6. according to claim 1 or 2 or 5 the methods, which is characterized in that breaking-wall cell breaking method is dry method in step (3), Crushing temperature is -15 DEG C~-30 DEG C, and grinding time is 10~30min.
7. method according to claim 3, which is characterized in that breaking-wall cell breaking method is dry method in step (3), crushes temperature Degree is -15 DEG C~-30 DEG C, and grinding time is 10~30min.
8. method according to claim 4, which is characterized in that breaking-wall cell breaking method is dry method in step (3), crushes temperature Degree is -15 DEG C~-30 DEG C, and grinding time is 10~30min.
CN201811362839.4A 2018-11-16 2018-11-16 A kind of compound fritillaria dissipates the health type preparation method of breaking-wall cell powder Pending CN109223715A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1541770A (en) * 2003-07-10 2004-11-03 中山大学 Low-temperature ultramicro disintegrating method of Chinese traditional medicinal materials
CN102526124A (en) * 2011-01-31 2012-07-04 成都科尔医药技术有限公司 Traditional Chinese medicinal powder and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1541770A (en) * 2003-07-10 2004-11-03 中山大学 Low-temperature ultramicro disintegrating method of Chinese traditional medicinal materials
CN102526124A (en) * 2011-01-31 2012-07-04 成都科尔医药技术有限公司 Traditional Chinese medicinal powder and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
中国硅酸盐学会陶瓷分会建筑卫生陶瓷专业委员会: "《现代建筑卫生陶瓷工程师手册》", 31 August 1998 *
乐大勇等: "复方贝母散超微粉体、细粉的化学性质与药效学对比", 《中国实验方剂学杂志》 *

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Application publication date: 20190118