CN109212234A - A kind of POCT glycolated hemoglobin analysis and POCT glycosylated hemoglobin analysis system - Google Patents
A kind of POCT glycolated hemoglobin analysis and POCT glycosylated hemoglobin analysis system Download PDFInfo
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- CN109212234A CN109212234A CN201811018418.XA CN201811018418A CN109212234A CN 109212234 A CN109212234 A CN 109212234A CN 201811018418 A CN201811018418 A CN 201811018418A CN 109212234 A CN109212234 A CN 109212234A
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- poct
- hemoglobin analysis
- kit
- detection device
- mounting plate
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/723—Glycosylated haemoglobin
Abstract
The present invention discloses a kind of POCT glycolated hemoglobin analysis and POCT glycosylated hemoglobin analysis system, the POCT glycolated hemoglobin analysis includes operating platform, locating piece, the first driving mechanism, piston briquetting and detection device, and the operating platform is equipped with the mounting plate upwardly extended；The locating piece is installed on the operating platform or the mounting plate along preceding rearwardly extending；First driving mechanism is installed on the mounting plate, and with one along preceding rearwardly extending drive shaft, the drive shaft is connected with revolving part, and the revolving part is equipped with along preceding rearwardly extending drive rod, and the axis of the drive rod is not overlapped with the axis of the drive shaft；The piston briquetting is located at the top of the revolving part, and the piston briquetting can be installed on up or down on the mounting plate；The detection device can be installed on up or down on the mounting plate.POCT glycolated hemoglobin analysis of the present invention has the advantages that easy to operate, test result is accurate.
Description
Technical field
The present invention relates to glycosylated hemoglobin detection technique field, in particular to a kind of POCT glycolated hemoglobin analysis
And POCT glycosylated hemoglobin analysis system.
Background technique
Glycosylated hemoglobin (HbA1c) is product of the hemoglobin in conjunction with blood glucose in red blood cell in blood.According to the world
Map the 8th edition report of global diabetes of 2017 of diabetes alliance (IDF) newest publication, there are 4.25 hundred million adults in the whole world in 2017
People is diabetic, and year-on-year upper one year increases by 2.41%.There are about 1.144 hundred million diabetics for China, separately there is more than 8,750 ten thousand sugar
Urinate " reserves " of patient's high risk.The diabetic for being estimated to be half does not obtain comprehensive diagnosis management.Glycosuria
The treatment key of disease is the control and stabilization of blood glucose level, mainly passes through detection patient empty stomach and meal to the diagnosis of diabetes at present
2 hours blood glucose values are judged afterwards, but influence vulnerable to the diet and held drug etc. of patient in the sampling observation period,
Patient's body blood glucose cannot be objectively responded is really situation.Studies have shown that the average life span of hemoglobin is up to 120 days, and
The formation speed of HbA1c is directly proportional to glucose concentration level in 8-12 weeks in the past, and therefore, HbA1c level can be more accurately anti-
Reflect 8-12 intracorporal blood glucose situation of all people in the past.And glycosylated hemoglobin not by blood drawing the time, whether on an empty stomach, whether use pancreas
Island is plain and other can be such that the factor of blood glucose level brief fluctuations influences.Glycosylated hemoglobin detect high specificity, it is reproducible,
High sensitivity is expressly stated and monitors " goldstandard " for internationally recognized diabetes.
However, the analyzer of currently used detection glycosylated hemoglobin concentration, the degree of automation are generally lower.It is using
In the process, manual operation step is more, for example, the addition of blood sample, the mixing of sample and reaction solution, sample and reaction solution
Addition and the addition of eluent of mixed liquor etc. require user's manual operations, complicated for operation, the precision of test result compared with
It is low.
Summary of the invention
The main object of the present invention is to propose a kind of POCT glycosylated hemoglobin easy to operate, test result precision is high
Analyzer.
To achieve the above object, a kind of POCT glycolated hemoglobin analysis proposed by the present invention, the POCT saccharification blood
Lactoferrin analyzer includes:
Operating platform, the operating platform are equipped with the mounting plate upwardly extended；
Locating piece, along preceding rearwardly extending, the locating piece is installed on the operating platform or the mounting plate；
First driving mechanism is installed on the mounting plate, and with one along preceding rearwardly extending drive shaft, the drive shaft
It is connected with revolving part, the revolving part is equipped with along preceding rearwardly extending drive rod, the axis of the drive rod and the driving
The axis of axis is not overlapped；
Piston briquetting, positioned at the top of the revolving part, the piston briquetting can be installed on the installation up or down
On plate；
Detection device, the detection device can be installed on up or down on the mounting plate.
Preferably, the piston briquetting is installed on the bottom of the detection device.
Preferably, it is provided through detection through-hole on the piston briquetting, so that the detection device sends and receives inspection
Survey signal.
Preferably, the POCT glycolated hemoglobin analysis further includes the second driving mechanism, second driving mechanism
The detection device is connected, to drive the detection device to move up and down.
Preferably, second driving mechanism includes the second motor, driving wheel, driven wheel and transmission belt, first electricity
Machine is installed on the mounting plate, and the driving wheel connects second motor, the transmission belt be sheathed on the driving wheel and
The driven wheel, the detection device connect the transmission belt.
Preferably, the bottom of the detection device is additionally provided with the spacing lever extended downwardly.
Preferably, the POCT glycolated hemoglobin analysis further includes kit bracket, the kit bracket can before
It is movably installed on the operating platform afterwards.
Preferably, the POCT glycolated hemoglobin analysis further includes third driving motor, the third driving motor
The kit bracket is connected, to drive the kit bracket to be moved forward and backward.
Preferably, the operating platform is equipped with the support plate positioned at kit bracket side, the third driving
Mechanism includes third motor, gear and the rack gear engaged with the gear, and the third motor is installed on the support plate, described
Gear connects the third motor, and the rack gear is along the preceding rearwardly extending and connection kit bracket.
The present invention also proposes a kind of POCT glycosylated hemoglobin analysis system, including POCT glycolated hemoglobin analysis and
The kit being adapted to the POCT glycolated hemoglobin analysis, wherein the POCT glycolated hemoglobin analysis includes:
Operating platform, the operating platform are equipped with the mounting plate upwardly extended；
Locating piece, along preceding rearwardly extending, the locating piece is installed on the operating platform or the mounting plate；
First driving mechanism is installed on the mounting plate, and with one along preceding rearwardly extending drive shaft, the drive shaft
It is connected with revolving part, the revolving part is equipped with along preceding rearwardly extending drive rod, the axis of the drive rod and the driving
The axis of axis is not overlapped；
Piston briquetting, positioned at the top of the revolving part, the piston briquetting can be installed on the installation up or down
On plate；
Detection device, the detection device can be installed on up or down on the mounting plate.
Technical solution of the present invention by the way that the mounting plate upwardly extended is arranged on the operational platform, in the operating platform or
It is arranged on the mounting plate along preceding rearwardly extending locating piece, while the first driving mechanism is set on the mounting plate, it is described
First driving mechanism has one along preceding rearwardly extending drive shaft, and the drive shaft is connected with revolving part, sets on the revolving part
Have along preceding rearwardly extending drive rod, the axis of the drive rod is not overlapped with the axis of the drive shaft；On the mounting plate
It is additionally provided with piston briquetting moving up and down and detection device, in this way, working as using the analyzer to the blood sample in kit
When being detected, fixed body is fixed by locating piece, and kit rotary body is then connect with drive rod, so that the first driving mechanism is logical
Axis of overdriving drives revolving part rotation, and revolving part can drive the rotation of kit rotary body by drive rod again, so that blood can be realized
The automatic mixing of liquid sample and reaction solution can also realize automatic addition and the eluent of the mixed liquor of blood sample and reaction solution
Automatic addition, enormously simplifies the operating procedure of analyzer, improves the accuracy and precision of testing result.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
The structure shown according to these attached drawings obtains other attached drawings.
Fig. 1 is the structural schematic diagram of POCT glycolated hemoglobin analysis of the present invention；
Fig. 2 is the structure chart for the kit being adapted to POCT glycolated hemoglobin analysis of the present invention；
Fig. 3 is the sectional view of kit shown in Fig. 2；
Fig. 4 is the hemostix structure figure of kit described in Fig. 2；
Fig. 5 is the assembling detail figure of kit and hemostix described in Fig. 2；
Fig. 6 is the first usage state diagram of kit shown in Fig. 2；
Fig. 7 is the second usage state diagram of kit shown in Fig. 2；
Fig. 8 is the third usage state diagram of kit shown in Fig. 2；
Fig. 9 is the first use state of POCT glycolated hemoglobin analysis shown in FIG. 1 and kit shown in Fig. 2
Figure；
Figure 10 is the second use state of POCT glycolated hemoglobin analysis shown in FIG. 1 and kit shown in Fig. 2
Figure；
Figure 11 is the third use state of POCT glycolated hemoglobin analysis shown in FIG. 1 and kit shown in Fig. 2
Figure.
Drawing reference numeral explanation:
The embodiments will be further described with reference to the accompanying drawings for the realization, the function and the advantages of the object of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiment is only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts it is all its
His embodiment, shall fall within the protection scope of the present invention.
It is to be appreciated that if relating to directionality instruction (such as up, down, left, right, before and after ...) in the embodiment of the present invention,
Then directionality instruction be only used for explain under a certain particular pose (as shown in the picture) between each component relative positional relationship,
Motion conditions etc., if the particular pose changes, directionality instruction is also correspondingly changed correspondingly.
In addition, being somebody's turn to do " first ", " second " etc. if relating to the description of " first ", " second " etc. in the embodiment of the present invention
Description be used for description purposes only, be not understood to indicate or imply its relative importance or implicitly indicate indicated skill
The quantity of art feature." first " is defined as a result, the feature of " second " can explicitly or implicitly include at least one spy
Sign.It in addition, the technical solution between each embodiment can be combined with each other, but must be with those of ordinary skill in the art's energy
It is enough realize based on, will be understood that the knot of this technical solution when conflicting or cannot achieve when occurs in the combination of technical solution
Conjunction is not present, also not the present invention claims protection scope within.
The present invention proposes a kind of POCT glycosylated hemoglobin analysis system.The POCT glycosylated hemoglobin analysis system includes
POCT glycolated hemoglobin analysis and the kit being adapted to the POCT glycolated hemoglobin analysis.Wherein, the analysis system
System has the advantages that easy to operate, result is accurate.
The structure of the POCT glycolated hemoglobin analysis will be specifically introduced below.
Referring to Fig. 1, a kind of POCT glycolated hemoglobin analysis 200 proposed by the present invention, including operating platform 210,
Locating piece 220, the first driving mechanism 230, piston briquetting (not shown) and detection device 240.The operating platform 210 is equipped with
The mounting plate 211 upwardly extended；For the locating piece 220 along preceding rearwardly extending, the locating piece 220 is installed on the operating platform
210 or the mounting plate 211 on.First driving mechanism 230 is installed on the mounting plate 211, and have one along front and back to
The drive shaft (not shown) of extension, the drive shaft are connected with revolving part 232, and the revolving part 232 is equipped with along front and back to prolonging
The axis of the drive rod 233 stretched, the drive rod 233 is not overlapped with the axis of the drive shaft.The piston briquetting is located at institute
The top of revolving part 232 is stated, the piston briquetting can be installed on up or down on the mounting plate 211.The detection device
240 can be installed on up or down on the mounting plate 211, the HbAle egg to object to be detected in detection kit 100
White concentration.
Wherein, kit 100 includes rotary body 110 and fixed body 120 (as shown in Figure 2).The locating piece 220 is for solid
Determine the fixed body 120 of kit 100, the drive rod 233 is used to connect the rotary body 110 of kit 100, to drive the examination
The rotary body 110 of agent box 100 rotates.Specifically, the rotary body 110 is equipped with the limit for the drive rod 233 insertion
Hole 170, the fixed body 120 are equipped with the fixing groove 180 for the locating piece 220 insertion.Here, it is to be appreciated that in order to
So that rotary body 110 is rotated relative to fixed body 120, the axis of the drive rod 233 is not overlapped with the axis of the drive shaft,
That is, the axis of the axis of the drive rod 233 and the drive shaft is not point-blank.First driving mechanism 230 is wrapped
First motor is included, the first motor drives the rotary body 110 to revolve mainly to drive the swivel mount 232 to rotate
Turn.In addition, the structure of the revolving part 232 can there are many, for example, the revolving part 232 can be supporting structure, plate knot
Structure or rod-like structure etc., are not specifically limited herein.There are many structures of the locating piece 220, for example, the locating piece
220 can be positioning pin etc., also be not specifically limited herein.
The piston briquetting is mainly used for pushing the piston (first piston 140 and second piston 133) on kit 100,
The liquid in the reaction sap cavity 113 of kit 100 and cleaning sap cavity 114 is added drop-wise to filter membrane 122 (as shown in Figure 3) to realize
On.Wherein, the piston briquetting, which can be, is set in the detection device 240, is also possible to the detection device 240 solely
It erects and sets, i.e., the described piston briquetting is not located in detection device 240.In embodiments of the present invention, in order to enable operation is more square
Just, the piston briquetting can be arranged in the bottom of detection device 240, in this way can piston briquetting can be with detection device 240
It moves up and down and moves up and down.Specifically, the piston briquetting is formed by the downward projection in bottom of the detection device 240, institute
State piston briquetting can rounded, rectangular or other profiled shapes, be not specifically limited herein.
The detection device 240 include signal projector and signal processor, the signal projector be used for it is described to
Detectable substance transmitting detection signal, the signal processor are used to receive the detection signal through the object reflection to be detected and export
Testing result.Specifically, detection through-hole (not shown) is provided through on the piston briquetting, for the detection device 240
Send and receive detection signal.In addition, the detection device 240 further includes testing jig 242, the piston briquetting is set to the survey
Try the bottom of frame 242.
Technical solution of the present invention on operating platform 210 by being arranged the mounting plate upwardly extended 211, in the operation
Setting is arranged along preceding rearwardly extending locating piece 220, while on the mounting plate 211 on platform 210 or the mounting plate 211
First driving mechanism 230, first driving mechanism 230 is with one along preceding rearwardly extending drive shaft, the driving axis connection
Have a revolving part 232, the revolving part 232 is equipped with along preceding rearwardly extending drive rod 233, the axis of the drive rod 233 with
The axis of the drive shaft is not overlapped；Piston briquetting moving up and down and detection device are additionally provided on the mounting plate 211
240, in this way, kit fixed body passes through when being detected using the analyzer 200 to the blood sample in kit 100
Locating piece 220 is fixed, and kit rotary body is then connect with drive rod 233, so that the first driving mechanism 230 is driven by drive shaft
Revolving part 232 rotates, and revolving part 232 can drive the rotation of kit rotary body by drive rod 233 again, so, it can be achieved that blood
The automatic mixing of sample and reaction solution can also realize oneself of addition and eluent automatically of the mixed liquor of blood sample and reaction solution
Dynamic addition, enormously simplifies the operating procedure of analyzer 200, improves the accuracy and precision of testing result.
The structure of kit 100 will be described in detail below.Fig. 2 to Fig. 5 is please referred to, the rotary body 110 has
Mounting hole 111, the rotary body 110 be equipped with the detection mouth 112 being circumferentially arranged along the mounting hole 111, reaction sap cavity 113 and
Clean sap cavity 114, the detection mouth 112 be connected to the mounting hole 111, the reaction sap cavity 113 pass through first runner 117 and
The mounting hole 111 is connected to, and the cleaning sap cavity 114 is connected to by second flow channel 118 with the mounting hole 111.The fixation
Body 120 has an open accommodation groove 121, and filter membrane 122 is provided in the accommodation groove 121, and the fixed body 120 is rotatablely installed
In in the mounting hole 111, the fixed body 120 can be rotated relative to the rotary body 110, and optionally make the filter membrane
122 is corresponding with the first runner 117, the second flow channel 118 and the detection mouth 112.
In embodiments of the present invention, rotary body 110 is substantially arranged in semi-cylindrical, and certainly, the shape of rotary body 110 is not yet
It is limited to this, the setting for example, rotary body 110 can also be square.The rounded setting of the mounting hole 111, the fixed body
120 have the segmental arc sealed against with the inner wall of the mounting hole 111.In a preferred embodiment, the mounting hole 111 is
By opposite two surfaces (front surface and rear surface) perforative through-hole of the rotary body 110.It is to be appreciated that in other embodiments
In, the mounting hole 111 or blind hole.The detection mouth 112 is connected to the mounting hole 111, and can be by the fixation
Expose 120 part of body.In this way, when rotary body 110 rotates to the filter membrane 122 for making detection mouth 112 face the fixed body 120
When, can on filter membrane 122 hemoglobin and glycosylated hemoglobin respectively wavelength 625nm and 460nm light irradiation under it is anti-
The rate of penetrating is tested and analyzed, to obtain the concentration of HbA1c in blood sample.
The reaction sap cavity 113 is in be spaced apart along the circumferential direction of the rotary body 110 with the cleaning sap cavity 114.About
It is described reaction sap cavity 113 and it is described cleaning sap cavity 114 distribution mode there are many, for example, the reaction sap cavity 113 and it is described clearly
Washing lotion chamber 114 can be located at the side (left or right side) of the symmetry axis of the rotary body 110, and operation so can be effectively reduced
Step.Certainly, the reaction sap cavity 113 and the cleaning sap cavity 114 may be alternatively located at the two of the symmetry axis of the rotary body 110
Side is not specifically limited herein.Preferably, the reaction sap cavity 113 is arranged adjacent to the cleaning sap cavity 114, so convenient for
Reaction solution and cleaning solution are instilled on the filter membrane 122 of fixed body 120.
The kit 100 further includes hemostix 130.The hemostix 130 is volumetric hemostix 130, can when unused
Using independent packaging, and production meets third class medical devices call, meets the requirement of sterilization.The hemostix 130
It after acquiring blood sample, is directly mounted in the reaction sap cavity 113 of kit 100, then will have the examination of hemostix 130
Agent box 100 is installed in analyzer 200, carries out operation to kit 100 by analyzer 200, to blood sample and reaction solution into
Row mixes；Then the blood sample by reaction is tested again, finally obtains measurement result.Therefore, reduce artificial system
The step of standby test sample, to operate simpler, and test result is more accurate.
It should be noted that in embodiments of the present invention, be by by rotary body 110 alternately clockwise or counterclockwise
Predetermined angle is rotated, to make to react what the reaction solution in sap cavity 113 was uniformly mixed with the blood sample in hemostix 130, thus
The degree of automation for improving the kit 100 of the detection glycosylated hemoglobin concentration reduces artificial participation step.
In embodiments of the present invention, the substantially cylindrical setting of fixed body 120, certainly, the shape of fixed body 120 is also unlimited
In this.The top of the fixed body 120 is equipped with mounting plane, and the mounting plane, which is recessed downwards, forms the accommodation groove 121, institute
It states filter membrane 122 to be installed in the accommodation groove 121, will further drop to this by the 122 filtered liquid (waste liquid) of filter membrane
The bottom of accommodation groove 121.That is, 121 one side of accommodation groove can be used for installing filter membrane 122, on the other hand can also be used in
Collect waste liquid.
In addition, the kit 100 further includes filter membrane lid 123, the filter membrane lid 123 is covered on the accommodation groove 121
Open end, and the bottom of filter membrane lid 123 is connected to filter membrane 122.The filter membrane lid 123 is provided with the water conservancy diversion through its upper and lower surface
Slot, will be on liquid guide flow to filter membrane 122.In this embodiment, the diversion trench is in tapered setting from top to bottom；Preferably,
The diversion trench is funnel-shaped.
Referring to Fig. 3, being additionally provided with the pressure mouth 124 that loses heart on the fixed body 120, the fixed body 120 can the relatively described rotation
110 rotation of swivel, and make the discouraged pressure mouth 124 successively by the second flow channel 118 and the first runner 117.Here,
The effect of the discouraged pressure mouth 124 is to be used to carry out pressure release with the second flow channel 117 for the first runner 117, so as to
The liquid effectivelying prevent in reaction sap cavity 113 sprays when oozing from first runner 117, and effectively prevent cleaning sap cavity
Liquid in 114 sprays when oozing from second flow channel 118, in this way, being conducive to the liquid that quantitative control oozes, is also beneficial to
Control liquid oozes rate.
It should be noted that hemostix 130 can be to reaction sap cavity when due to by 130 intercalation reaction sap cavity 113 of hemostix
Gas in 113 is compressed, and is higher than ambient pressure so as to cause the air pressure in reaction sap cavity 113.If losing heart without described
124 pressure release of mouth is pressed, and directly drops to the mixing liquid reacted in sap cavity 113 on filter membrane 122, then the mixing liquid is easy to happen
Injection, to be difficult to control the volume for the mixing liquid dripped, it is also difficult to the rate for controlling mixing liquid drippage, eventually to survey
The accuracy of test result affects.
Equally, in order to make the inner and outer air pressure for cleaning sap cavity 114 keep balance, prevent the liquid that will be cleaned in sap cavity 114 from dripping
It is sprayed when dropping down on filter membrane 122, it is also desirable to which the pressure mouth 124 that makes to lose heart is by second flow channel 118, so as to clean sap cavity 114
Inner and outer air pressure keeps balance.
Referring to Fig. 3, the kit 100 further includes first piston 140, the first piston 140 is slidably mounted on institute
It states in cleaning sap cavity 114.
Further, one end far from the second flow channel 118 of the cleaning sap cavity 114, be formed with it is clear described in this
The plunger shaft 116 that washing lotion chamber 114 is connected to, for the first piston 140 installation.Preferably, the internal diameter of the plunger shaft 116 is big
In the internal diameter of the cleaning sap cavity 114, the first piston 140 is slidably mounted in the plunger shaft 116.
In embodiments of the present invention, the kit 100 further includes reaction solution and cleaning solution, and the reaction solution is sealed in institute
It states in reaction sap cavity 113, the cleaning solution is sealed in the cleaning sap cavity 114.Wherein, red thin containing cleavable in reaction solution
The substance that born of the same parents, release hemoglobin precipitate and the blue boric acid conjugate that can be closed with the syn-diol base junction of glycosylated hemoglobin,
When blood sample instills in reaction solution, red blood cell is cleaved immediately, all hemoglobin precipitatings, boric acid conjugate then with saccharification blood
The syn-diol base junction of Lactoferrin is closed.Suitable reaction mixture is placed on filter membrane 122, all settled hemoglobins
It whether is it being combined by boric acid conjugate, will all remain on filter membrane 122, and then wash away extra dyeing with cleaning solution and sew
Close object.Respectively using 200 pairs of blues (glycosylated hemoglobin) of glycolated hemoglobin analysis and red (total hemoglobin) finally
Reflectivity under the light irradiation of wavelength 625nm and 460nm is analyzed, and the concentration of HbA1c in blood sample is obtained.
Specifically, the kit 100 further includes the first sealing film 150 and the second sealing film 160, the first sealing film
150 the reaction solution to be sealed in the reaction sap cavity 113, and the second sealing film 160 is to by the cleaning solution
It is sealed in the cleaning sap cavity 114.Wherein, the first sealing film 150 is equipped with mark line 151, to mark described adopt
The insertion position of blood device 130.It makes mistakes when in this way can be to avoid the insertion of hemostix 130, causes the loss of blood sample, thus
Significantly improve the utilization rate of blood sample.
Referring to Fig. 4, the hemostix 130 includes blood sampling cylinder 131, blood collection needles 132 and second piston 133, it is described to adopt
Blood cylinder 131 is removably installed in the hemostix chamber 113b.Described adopt is removably installed in about the blood sampling cylinder 131
There are many modes in blood device chamber 113b, is not specifically limited.The blood collection needles 132 are made of glass, for directly and people
Blood was collected for body contact.In this embodiment, the front outer of the blood sampling cylinder 131 is equipped with elastic sealing element 134, the blood sampling
The inner wall of the cylinder 131 and hemostix chamber 113b is tightly connected by the elastic sealing element 134.Specifically, the elasticity is close
Sealing 134 can be the front outer for being set in the blood sampling cylinder 131, be also possible to be shaped in the blood sampling cylinder 131
On front outer.Preferably, the elastic sealing element 134 is sealing ring.
First runner 117 is set to face fixed body when the first driving mechanism 230 drives rotary body 110 to be rotated clockwise to
Filter membrane 122 (as shown in Figure 6) in 120 makes piston briquetting driving a reaction sap cavity 113 at this point, driving piston briquetting moves downward
Interior piston (namely second piston 133) moves downward, so that the liquid in reaction sap cavity 113 is flowed through first runner 117
Out, it and drops on the filter membrane 122 of fixed body 120.
Second flow channel 118 is set to face fixed body when the first driving mechanism 230 drives rotary body 110 to be rotated clockwise to
Filter membrane 122 (as shown in Figure 7) in 120 makes piston briquetting push cleaning sap cavity 114 at this point, driving piston briquetting moves downward
Interior piston (first piston 140) moves downward, so that the liquid in cleaning sap cavity 114 is flowed out through second flow channel 118, and
It drops on the filter membrane 122 of fixed body 120.
The detection mouth 112 is set to be located just at fixation when the first driving mechanism 230 drives rotary body 110 to be rotated clockwise to
122 top (as shown in Figure 8 and Figure 11) of filter membrane of body 120 makes piston briquetting just at this point, driving piston briquetting moves downward
When touching filter membrane lid 123, the detection device 240 above piston briquetting can be tested, and obtain final result.
Fig. 1, Fig. 9, Figure 10 are please referred to, in order to improve the degree of automation of analyzer 200, reduces the operation manually participated in,
In this embodiment, the POCT glycolated hemoglobin analysis 200 further includes the second driving mechanism 250, second driving
Mechanism 250 connects the detection device 240, to drive the detection device 240 to move up and down.It should be noted that described
Second driving mechanism 250 can be moved up and down by driving detection device 240 to move up and down with piston briquetting.
Structure about the second driving mechanism 250 has very much, does not also do particular determination.In a preferred embodiment, described
Second driving mechanism 250 includes the second motor 251, driving wheel 252, driven wheel 253 and transmission belt 254, second motor 251
It is installed on the mounting plate 211, the driving wheel 252 connects second motor 251, and the transmission belt 254 is sheathed on institute
Driving wheel 252 and the driven wheel 253 are stated, the detection device 240 connects the transmission belt 254.
Further, in order to guarantee that detection device 240 moves along the vertical direction, edge can be set on the mounting plate 211
The first sliding rail 256 that upward and downward extends, in the detection device 240 setting with first sliding rail 256 is adapted to first connect
Sliding block 255.Specifically, first connection sliding block 255 connects the transmission belt 254.
In addition, the bottom of the detection device 240 is additionally provided with the spacing lever 244 extended downwardly.The spacing lever 244
The effect for primarily serving limit kit 100, prevents kit 100 to be moved forward and backward.
Fig. 9, Figure 10 are please referred to, on the basis of the above embodiments, the POCT glycolated hemoglobin analysis 200 also wraps
Kit bracket 270 is included, the kit bracket 270 can be installed on movably forward and backward on the operating platform 210.
For the ease of automatic operation, the POCT glycolated hemoglobin analysis 200 further includes third driving mechanism
260, the third driving mechanism 260 connects the kit bracket 270, to drive the kit bracket 270 to be moved forward and backward.
About third driving mechanism 260 structure can also there are many, be not specifically limited herein.In one embodiment,
The operating platform 210 is equipped with the support plate 212 positioned at 270 side of kit bracket, the third driving mechanism 260
Including third motor 261, gear 262 and the rack gear 263 engaged with the gear 262, the third motor 261 is installed on described
Support plate 212, the gear 262 connect the third motor 261, and the rack gear 263 is along the preceding rearwardly extending and connection examination
(illustrate: it includes being directly connected to and being indirectly connected with two kinds of sides that rack gear 263 connects kit bracket 270 here to agent box bracket 270
Formula, herein simply to illustrate that driving mechanism is that kit bracket is driven to be moved forward and backward by way of rack and pinion engagement).
It is to be appreciated that in order to guarantee that kit bracket 270 moves along the longitudinal direction, it can be on the operating platform 210
It is arranged along preceding the second rearwardly extending sliding rail 265, and setting is adapted to second sliding rail 265 on the kit bracket 270
The second connection sliding block 266.Specifically, the rack gear 263 is set to the upper surface of second connection sliding block 266.Wherein, institute
Stating rack gear 263 can be second connection sliding block 266 is arranged in upper surface with being integrally formed, be also possible to removably set
It sets in the upper surface of second connection sliding block 266, is not specifically limited herein.
Kit is installed on kit bracket 270 for convenience, it is fixed that the two sides of the kit bracket 270 are equipped with two
Position part 271, the two sides of the kit 100 are equipped with the location hole 190 (as shown in Figure 2) being adapted to two locating pieces 271.Its
In, the structure about the locating piece 271 is not specifically limited, in one embodiment, in order to facilitate kit 100 and kit
The fixation of bracket 270 with separate, the locating piece 271 can be bulb plunger.
In addition, being detected in order to which more accurately kit is installed on analyzer 200, the POCT HbAle
Protein analyzer 200 further includes position sensor, position of the position sensor to sense the kit bracket 270.
About position sensor structure can there are many, be also not specifically limited herein.In one embodiment, the position sensor
Including the 264 baffle (not shown) of optocoupler being arranged on the kit bracket 270, and it is arranged in the support plate 212
And the optocoupler 264 (as shown in Figure 9) with 264 baffle of optocoupler cooperation.
Wherein, the quantity about the optocoupler 264 is not specifically limited, for example, the quantity of the optocoupler 264 can be one
It is a, two or three etc..In a preferred embodiment, it is arranged in the support plate 212 along front and back in three be spaced apart
Optocoupler 264.For ease of description, be distributed from front to back three optocouplers 264 can be successively defined as the first optocoupler 264a, second
Optocoupler 264b and third optocoupler 264c.Referring to Fig. 9, when kit bracket 270 travels forward, until 264 baffle of optocoupler triggers
When the signal of the first optocoupler 264a, kit bracket 270 is moved to outside analyzer 200, at this point, kit is packed into analyzer
In 200.Later, kit bracket 270 moves backward, when the signal of 264 baffle of optocoupler triggering third optocoupler 264c, at this time
Fixing groove 180 entangles locating piece 220 completely on kit 100, and the limit hole 170 of kit 100 entangles drive rod 233 completely.
Then, referring to Fig. 10, the second driving mechanism 250 driving detection device 240 moves downward, make the lower end position of spacing lever 244
110 front side is fixed in kit 100, at this point, making kit bracket 270 travel forward, since the limit of spacing lever 244 is made
With kit 100 is detached from kit bracket 270, and is left in place under the supporting role of locating piece 220 and drive rod 233, directly
264 baffle of optocoupler on to kit bracket 270 triggers the signal of the second optocoupler 264b.
Fig. 1, Fig. 9 are please referred to again, and in the various embodiments described above of the invention, the locating piece 220 is installed on the operation
On platform 210.Specifically, the operating platform 210 is equipped with the support post upwardly extended, and the locating piece 220 connects institute
State support post.In this way, on the one hand the support post can play the role of supporting positioning member 220, and then play support examination
The effect of agent box 100；On the other hand the support post can also play the role of kit bracket 270 described in stop.
The application method that will be apparent from POCT glycolated hemoglobin analysis 200 of the present invention below, specifically includes as follows
Step:
(1) it first passes through hemostix 130 and directly acquires blood sample, then the hemostix 130 that blood sample will be housed from human body
It is inserted directly into reaction sap cavity 113 (hemostix chamber 113b)；
(2) kit 100 is packed on kit bracket 270, kit bracket is driven by third driving mechanism 260
270 move backward, and the fixing groove 180 on kit 100 is made to entangle locating piece 220 completely, make the limit hole on kit 100
170 entangle drive rod 233 completely, drive kit bracket 270 to travel forward finally by third driving mechanism 260, make reagent
Box 100 is detached from kit bracket 270；
(3) revolving part 232 and drive rod 233 is driven to rotate by the first driving mechanism 230, so that rotary body 110
Around the alternately predetermined angle clockwise or counterclockwise of fixed body 120, so that reaction solution and blood sampling in reaction sap cavity 113
Blood sample in device 130 is uniformly mixed；
(4) it after mixing, drives rotary body 110 to rotate counterclockwise by the first driving mechanism 230, makes second flow channel 118, the
One runner 117 is successively by the pressure mouth 124 that loses heart, so that cleaning sap cavity 114 keeps balance with the inner and outer air pressure for reacting sap cavity 113；
(5) driving rotary body 110 to be rotated clockwise to by the first driving mechanism 230 again faces first runner 117
Filter membrane 122 (as shown in Figure 6) in fixed body 120, at this point, driving detection device 240 to transport downwards by the second driving mechanism 250
It is dynamic, so that piston moves downward in piston briquetting driving a reaction sap cavity 113, so that the liquid warp in reaction sap cavity 113
First runner 117 flows out, and drops on the filter membrane 122 of fixed body 120；Piston briquetting is moved upwards, and is detached from kit
100；
(6) it waits for a period of time after (such as 10~30s), drives rotary body 110 clockwise by the first driving mechanism 230
Rotating to makes second flow channel 118 face the filter membrane 122 (as shown in Figure 7) in fixed body 120, at this point, passing through the second driving machine
Structure 250 drives detection device 240 to move downward again, so that piston briquetting moves downward again, and pushes in cleaning sap cavity 114
Piston moves downward, so that the liquid in cleaning sap cavity 114 is flowed out through second flow channel 118, and drops to fixed body 120
On filter membrane 122；Piston briquetting is moved upwards, and is detached from kit 100；
(7) it waits for a period of time after (such as 10~30s), drives rotary body 110 clockwise by the first driving mechanism 230
122 top (as shown in Figure 8) of filter membrane for making the detection mouth 112 be located just at fixed body 120 is rotated to, at this point, passing through second
Driving mechanism 250 drives detection device 240 to move downward again, when piston briquetting being made just to touch filter membrane lid 123, piston pressure
Detection device 240 above block can be tested, and obtain final result.
It should be noted that treated blood sample can also be acquired by hemostix 130 in above-mentioned steps (1)
Then the kit 100 with the hemostix 130 is attached in glycolated hemoglobin analysis 200 and detects by product.In this way
It may dispense with step (3), so as to be further simplified operating procedure.
The above description is only a preferred embodiment of the present invention, is not intended to limit the scope of the invention, all at this
Under the inventive concept of invention, using equivalent structure transformation made by description of the invention and accompanying drawing content, or directly/use indirectly
It is included in other related technical areas in scope of patent protection of the invention.
Claims (10)
1. a kind of POCT glycolated hemoglobin analysis, which is characterized in that the POCT glycolated hemoglobin analysis includes:
Operating platform, the operating platform are equipped with the mounting plate upwardly extended；
Locating piece, along preceding rearwardly extending, the locating piece is installed on the operating platform or the mounting plate；
First driving mechanism is installed on the mounting plate, and with one along preceding rearwardly extending drive shaft, the driving axis connection
There is revolving part, the revolving part is equipped with along preceding rearwardly extending drive rod, the axis of the drive rod and the drive shaft
Axis is not overlapped；
Piston briquetting, positioned at the top of the revolving part, the piston briquetting can be installed on up or down on the mounting plate；
Detection device, the detection device can be installed on up or down on the mounting plate.
2. POCT glycolated hemoglobin analysis as described in claim 1, which is characterized in that the piston briquetting is installed on institute
State the bottom of detection device.
3. POCT glycolated hemoglobin analysis as claimed in claim 2, which is characterized in that run through on the piston briquetting and set
It is equipped with detection through-hole, so that the detection device sends and receives detection signal.
4. POCT glycolated hemoglobin analysis as claimed in claim 2, which is characterized in that the POCT glycosylated hemoglobin
Analyzer further includes the second driving mechanism, and second driving mechanism connects the detection device, to drive the detection to fill
It sets and moves up and down.
5. POCT glycolated hemoglobin analysis as claimed in claim 4, which is characterized in that second driving mechanism includes
Second motor, driving wheel, driven wheel and transmission belt, second motor are installed on the mounting plate, the driving wheel connection
Second motor, the transmission belt are sheathed on the driving wheel and the driven wheel, and the detection device connects the transmission
Band.
6. POCT glycolated hemoglobin analysis as described in claim 1, which is characterized in that the bottom of the detection device is also
Equipped with the spacing lever extended downwardly.
7. POCT glycolated hemoglobin analysis as described in claim 1, which is characterized in that the POCT glycosylated hemoglobin
Analyzer further includes kit bracket, and the kit bracket can be installed on movably forward and backward on the operating platform.
8. POCT glycolated hemoglobin analysis as claimed in claim 7, which is characterized in that the POCT glycosylated hemoglobin
Analyzer further includes third driving motor, and the third driving motor connects the kit bracket, to drive the kit
Bracket is moved forward and backward.
9. POCT glycolated hemoglobin analysis as claimed in claim 8, which is characterized in that the operating platform is equipped with position
Support plate in kit bracket side, the third driving mechanism include third motor, gear and nibble with the gear
The rack gear of conjunction, the third motor are installed on the support plate, and the gear connects the third motor, and the rack gear is along front and back
To extending and connect the kit bracket.
10. a kind of POCT glycosylated hemoglobin analysis system, which is characterized in that including as described in claim 1 to 9 any one
POCT glycolated hemoglobin analysis, and the kit being adapted to the POCT glycolated hemoglobin analysis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811018418.XA CN109212234B (en) | 2018-08-31 | 2018-08-31 | POCT (Point of Care testing) glycosylated hemoglobin analyzer and POCT glycosylated hemoglobin analysis system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811018418.XA CN109212234B (en) | 2018-08-31 | 2018-08-31 | POCT (Point of Care testing) glycosylated hemoglobin analyzer and POCT glycosylated hemoglobin analysis system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109212234A true CN109212234A (en) | 2019-01-15 |
| CN109212234B CN109212234B (en) | 2021-07-20 |
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| CN201811018418.XA Active CN109212234B (en) | 2018-08-31 | 2018-08-31 | POCT (Point of Care testing) glycosylated hemoglobin analyzer and POCT glycosylated hemoglobin analysis system |
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| US20100229635A1 (en) * | 2009-03-13 | 2010-09-16 | Terrasep, Llc | Methods and apparatus for centrifugal liquid chromatography |
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| CN103499701A (en) * | 2013-09-04 | 2014-01-08 | 深圳市锦瑞电子有限公司 | Specific protein analyzer and analysis method thereof |
| CN104483499A (en) * | 2014-12-30 | 2015-04-01 | 深圳市汇松科技发展有限公司 | Full-automatic particular protein analyzer |
| US20160363604A1 (en) * | 2011-10-18 | 2016-12-15 | Hitachi High-Technologies Corporation | Automated analyzer |
| CN206975050U (en) * | 2017-06-20 | 2018-02-06 | 深圳市惠安生物科技有限公司 | Glycosylated hemoglobin reaction card from dynamic load card mechanism for testing |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100229635A1 (en) * | 2009-03-13 | 2010-09-16 | Terrasep, Llc | Methods and apparatus for centrifugal liquid chromatography |
| US20160363604A1 (en) * | 2011-10-18 | 2016-12-15 | Hitachi High-Technologies Corporation | Automated analyzer |
| CN103063856A (en) * | 2013-01-04 | 2013-04-24 | 长春迪瑞医疗科技股份有限公司 | Full-automatic fecal occult blood analyzer |
| CN103499701A (en) * | 2013-09-04 | 2014-01-08 | 深圳市锦瑞电子有限公司 | Specific protein analyzer and analysis method thereof |
| CN104483499A (en) * | 2014-12-30 | 2015-04-01 | 深圳市汇松科技发展有限公司 | Full-automatic particular protein analyzer |
| CN206975050U (en) * | 2017-06-20 | 2018-02-06 | 深圳市惠安生物科技有限公司 | Glycosylated hemoglobin reaction card from dynamic load card mechanism for testing |
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| Publication number | Publication date |
|---|---|
| CN109212234B (en) | 2021-07-20 |
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