CN109200445A - A kind of suck-back-prevention type chemical spraying device that cooperation endoscope uses - Google Patents
A kind of suck-back-prevention type chemical spraying device that cooperation endoscope uses Download PDFInfo
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- CN109200445A CN109200445A CN201810995523.2A CN201810995523A CN109200445A CN 109200445 A CN109200445 A CN 109200445A CN 201810995523 A CN201810995523 A CN 201810995523A CN 109200445 A CN109200445 A CN 109200445A
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- 238000005507 spraying Methods 0.000 title claims abstract description 19
- 239000000126 substance Substances 0.000 title claims abstract description 19
- 239000000843 powder Substances 0.000 claims abstract description 72
- 238000007906 compression Methods 0.000 claims abstract description 39
- 230000006835 compression Effects 0.000 claims abstract description 39
- 239000003814 drug Substances 0.000 claims abstract description 13
- 239000012528 membrane Substances 0.000 claims abstract description 8
- 239000002071 nanotube Substances 0.000 claims description 51
- HPTYUNKZVDYXLP-UHFFFAOYSA-N aluminum;trihydroxy(trihydroxysilyloxy)silane;hydrate Chemical compound O.[Al].[Al].O[Si](O)(O)O[Si](O)(O)O HPTYUNKZVDYXLP-UHFFFAOYSA-N 0.000 claims description 49
- 229910052621 halloysite Inorganic materials 0.000 claims description 42
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 30
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 30
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 23
- 239000004743 Polypropylene Substances 0.000 claims description 14
- -1 polypropylene Polymers 0.000 claims description 14
- 229920001155 polypropylene Polymers 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 10
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 9
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 9
- 235000012208 gluconic acid Nutrition 0.000 claims description 9
- 239000000174 gluconic acid Substances 0.000 claims description 9
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 8
- 229910052801 chlorine Inorganic materials 0.000 claims description 8
- 239000000460 chlorine Substances 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- 238000013019 agitation Methods 0.000 claims description 7
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 230000005855 radiation Effects 0.000 claims description 2
- 239000007921 spray Substances 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 5
- 238000001125 extrusion Methods 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 7
- 239000012047 saturated solution Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 229960003260 chlorhexidine Drugs 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 108010066057 cabin-1 Proteins 0.000 description 2
- 230000009881 electrostatic interaction Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000002324 minimally invasive surgery Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 2
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
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- 238000003825 pressing Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Abstract
The present invention relates to a kind of suck-back-prevention type chemical spraying devices that cooperation endoscope uses, including medicinal powder storehouse, flexible elongate tubular, compression bin, porous membrane, fixed plate, mobile bar, magnetic patch, closed plate.The phenomenon that inner space for squeezing compression bin allows the air in medicinal powder storehouse to spray from one end of flexible elongate tubular in turn, realizes the purpose of spray, and the setting of porous membrane can be avoided suck-back generation, so that medicinal powder be avoided to enter in compression bin.When flexible elongate tubular does not reach specified position, closed plate can play the role of saving medicinal powder, when flexible elongate tubular reaches medication position far from the one end in medicinal powder storehouse, squeeze compression bin, air extrusion closed plate is driven to overcome the attraction between two magnetic patch to allow closed plate no longer closing flexible long tube to allow medicinal powder to spray, after no longer squeezing compression bin, two magnetic patch will be mobile towards direction close to each other and then drive mobile bar and closed plate mobile, and closed plate is allowed to play the purpose of closing flexible long tube.
Description
Technical field
The present invention relates to the technical fields of medical instrument, more specifically, it be related to a kind of cooperation endoscope use it is anti-
Inverse inhalation type chemical spraying device.
Background technique
Minimally Invasive Surgery refers to the operation using the existing medical instrument such as laparoscope, thoracoscope and relevant device progress.It is minimally invasive
Operation is that wound is small, pain is light, restores fast compared to the advantages of traditional operative treatment.However, in some Minimally Invasive Surgeries, example
If organs resection is performed the operation, people needs to carry out the dispensing of drug, in order to reach hemostasis, anti-inflammatory, antibacterial and other effects.For the ease of throwing
Medicinal powder is put, people, which use, increases by one section of suction pipe in spray bottle front end, and guidance medicinal powder is launched to formulation part.However such equipment,
The phenomenon that often leading to a large amount of medicinal powder to remain in tubule, and then causing suck-back, therefore have much room for improvement.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to provide a kind of anti-suck that cooperation endoscope uses
Formula chemical spraying device has the advantages that anti-suck and avoids waste.
To achieve the above object, the present invention provides the following technical scheme that a kind of suck-back-prevention type that cooperation endoscope uses
Chemical spraying device, the medicinal powder storehouse including being set as hollow form, the one end in the medicinal powder storehouse are connected with flexible elongate tubular, the medicinal powder storehouse
The other end is threaded with deformable compression bin, and one end of medicinal powder storehouse towards the compression bin is provided with porous membrane, described
Flexible elongate tubular is connected with the fixed plate with opening away from the direction in medicinal powder storehouse, and the fixed plate slidably connects movement
Bar, the mobile bar and fixed plate are respectively arranged with the magnetic patch to attract each other, and the mobile bar is connected with soft for closing
The closed plate of property long tube.
By using above-mentioned technical proposal, squeezes the inner space of compression bin and then allow air in medicinal powder storehouse towards medicinal powder storehouse
Interior movement realizes spray to drive the medicinal powder in medicinal powder storehouse towards transfer in flexible elongate tubular and then spray from one end of flexible elongate tubular
Purpose, the drive of air can be avoided medicinal powder and be accumulated in flexible elongate tubular, avoids wasting, and the setting of porous membrane can be kept away
The phenomenon that exempting from suck-back generation, so that medicinal powder be avoided to enter in compression bin.When flexible elongate tubular does not reach specified position, closed plate
It can play the role of saving medicinal powder, when flexible elongate tubular reaches medication position far from the one end in medicinal powder storehouse, squeeze compression bin, band
Dynamic air extrusion closed plate is to overcome the attraction between two magnetic patch to allow closed plate no longer closing flexible long tube to allow medicine
Powder sprays, and after no longer squeezing compression bin, two magnetic patch will be mobile towards direction close to each other and then drive mobile bar and envelope
Closing plate is mobile, and closed plate is allowed to play the purpose of closing flexible long tube.
The present invention is further arranged to: the side wall in the medicinal powder storehouse is connected with more of medicinal powder storehouse sidewall slope tiltedly
Bar, the one end in the flexible elongate tubular towards medicinal powder storehouse are connected with cricoid card adapter plate, and the card adapter plate is provided with for oblique
The clamping groove that bar passes through.
By using above-mentioned technical proposal, card adapter plate and brace can be easily clamped, facilitates detachably connecting for the two
It connects, after not needing using the two, can dispense, transport.
The present invention is further arranged to: the flexible elongate tubular is set as horn-like far from the one end in medicinal powder storehouse.
By using above-mentioned technical proposal, horn-like setting can spray more medicinal powder, be conducive to increase medicinal powder
Usage amount.
The present invention is further arranged to: the compression bin is provided with multiple recirculation holes, the pressure far from the one end in medicinal powder storehouse
Contracting is fixedly connected with returning spring in storehouse.
By using above-mentioned technical proposal, after compression bin restores deformation under the deformability of itself, air will be from circulation
It is flowed into compression bin in hole, and then compression bin is allowed to have the ability for squeezing air again, returning spring can allow compression bin to have
Stronger recovery capacity.
The present invention is further arranged to: the brace is set as two.
By using above-mentioned technical proposal, the company arranged symmetrically that can either increase flexible elongate tubular and medicinal powder storehouse of two braces
Connect intensity, additionally it is possible to save material because of two settings.
The present invention is further arranged to: the side of the closed plate towards flexible elongate tubular is connected with the first guide plate,
The side of the flexible elongate tubular towards closed plate is connected with the second guide plate being bonded with the first guide plate.
By using above-mentioned technical proposal, the first guide plate and the second guide plate are bonded to each other, and can constitute closing
The motion track of plate, avoids closed plate from arbitrarily moving.
The present invention is further arranged to: the flexible elongate tubular according to parts by weight, including following component: halloysite nanotubes
60-80 parts, 10-15 parts of chlorhexidine gluconate, 5-8 parts of nano silver, 100-150 parts of polypropylene.
By using above-mentioned technical proposal, the antibiotic property of long tube can greatly be enhanced by constituting flexible elongate tubular using said components
Can, and the hollow structure of halloysite nanotubes is very enough that chlorhexidine gluconate and nano silver is allowed to be attached to its surface well,
And it is be easy to cause chlorhexidine gluconate and nano silver conglomerate during this, gluconic acid chlorine under the action of polypropylene
Oneself is fixed and nano silver can be uniformly distributed in halloysite nanotubes, in conjunction with more closely and capable of allowing the delaying of halloysite nanotubes
The time released extends, and increases antibacterial and uses the time.
It is a further object to provide a kind of method of modifying of halloysite nanotubes, step 1: according to parts by weight
Number, weighs 10-15 parts of chlorhexidine gluconate, formation chlorhexidine gluconate saturated solution soluble in water；
Step 2: according to parts by weight, weighing 60-80 parts of halloysite nanotubes, and use vacuum suction mode by gluconic acid chlorine
Oneself sucks in halloysite nanotubes surely；
Step 3: using magnetic agitation under vacuum conditions, and maintain 30-60min, then restore the chamber pressure of 10pa；
Step 4: the process of step 3 is repeated 2-3 times；
Step 5: the suspension that step 4 obtains being centrifuged 10min under the conditions of 9000r/min, then cleans 2 with deionized water
It is secondary, and in 50 DEG C of drying in oven, obtain head product；
Step 6: nano silver 5-8 parts being added according to parts by weight, in the head product obtained in steps of 5 and continues under uv radiation
30-70min, and be added 100-150 parts of polypropylene and modified halloysite nanotubes can be obtained.
By using above-mentioned technical proposal, UV irradiation can allow nano silver and head product to solidify rapidly, and gluconic acid
Chlorhexidine is successfully encapsulated in halloysite nanotubes chamber under the condition of negative pressure that vacuum generates, due to electrostatic interaction, band
The chlorhexidine gluconate of positive electricity can also be adsorbed on the electronegative outer surface of halloysite nanotubes.Modification galapectite after preparation
Nanotube has external slow-release function, can function well as antibacterial effect.Step 4 is repeated as many times available higher negative
Load rate enhances the Percentage bound of halloysite nanotubes and chlorhexidine gluconate.
In conclusion the invention has the following advantages:
1, the present invention squeezes the inner space of compression bin and then the air that allows in medicinal powder storehouse is towards mobile to drive medicine in medicinal powder storehouse
Medicinal powder in powder cabin is sprayed towards transfer in flexible elongate tubular and then from one end of flexible elongate tubular, realizes the purpose of spray, the band of air
It is dynamic to can be avoided medicinal powder and be accumulated in flexible elongate tubular, it avoids wasting, and hair the phenomenon that the setting of porous membrane can be avoided suck-back
It is raw, so that medicinal powder be avoided to enter in compression bin.When flexible elongate tubular does not reach specified position, closed plate can play preservation medicine
The effect of powder squeezes compression bin when flexible elongate tubular reaches medication position far from the one end in medicinal powder storehouse, drives air extrusion closing
Plate is to overcome the attraction between two magnetic patch to allow closed plate no longer closing flexible long tube to allow medicinal powder to spray, when no longer crowded
After pressing compression bin, two magnetic patch will be mobile towards direction close to each other and then drive mobile bar and closed plate mobile, allow closing
Plate plays the purpose of closing flexible long tube.
2, the present invention, which constitutes flexible elongate tubular using said components, can greatly enhance the anti-microbial property of long tube, and galapectite
The hollow structure of nanotube is very enough to allow chlorhexidine gluconate and nano silver to be attached to its surface well, and holds during this
Chlorhexidine gluconate and nano silver conglomerate are easily caused, chlorhexidine gluconate and nano silver meeting under the action of polypropylene
Be uniformly distributed in halloysite nanotubes, in conjunction with more closely and can allow halloysite nanotubes sustained release time extend,
Increase antibacterial and uses the time.
3, the present invention can allow nano silver and head product to solidify rapidly using UV irradiation, and chlorhexidine gluconate is true
It is successfully encapsulated in halloysite nanotubes chamber under the condition of negative pressure that sky generates, due to electrostatic interaction, positively charged grape
Saccharic acid Chlorhexidine can also be adsorbed on the electronegative outer surface of halloysite nanotubes.Modification halloysite nanotubes after preparation have
External slow-release function can function well as antibacterial effect.Step 4 is repeated as many times available higher load factor, enhancing
The Percentage bound of halloysite nanotubes and chlorhexidine gluconate.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of embodiment.
Appended drawing reference: 1, medicinal powder storehouse；2, flexible elongate tubular；3, compression bin；4, porous membrane；5, fixed plate；6, mobile bar；7,
Magnetic patch；8, closed plate；9, brace；10, card adapter plate；11, clamping groove；12, recirculation hole；13, returning spring；14, the first guide plate；
15, the second guide plate；16, jet tray；17, connecting rope.
Specific embodiment
Referring to attached drawing, the present invention will be further described.
A kind of suck-back-prevention type chemical spraying device that uses of cooperation endoscope includes the medicinal powder storehouse 1 for being set as hollow form, medicinal powder storehouse 1
One end be connected with flexible elongate tubular 2, the other end in medicinal powder storehouse 1 is threaded with deformable compression bin 3.Compression bin 3 is far from medicine
The side of powder cabin 1 is provided with multiple recirculation holes 12, increases and flows into the influx that air flows into compression bin 3.When compression bin 3 along
After the length direction deformation of itself, can squeeze internal air in turn will be in medicinal powder storehouse 1 to push air into medicinal powder storehouse 1
Medicinal powder is brought into flexible elongate tubular 2, and compression bin 3 will be restored because of the deformability of itself later, outside during this
Air will enter compression bin 3 in, so that compression bin 3 be allowed to have blowability again.There are two being fixedly connected in compression bin 3
The length direction of returning spring 13, each returning spring 13 is parallel with the length direction of compression bin 3, when compression bin 3 is along itself
Length direction deformation after, returning spring 13 can be squeezed, during compression bin 3 is returned to original state, 13 meeting of returning spring
Enhance the recovery capacity of compression bin 3.
One section of medicinal powder storehouse 1 towards compression bin 3 is provided with porous membrane 4, can be avoided the medicinal powder in medicinal powder storehouse 1 and enters pressure
In contracting storehouse 3, thus the phenomenon that avoiding suck-back generation.Away from the side integrally connected of compression bin 3, there are two relative to medicine in medicinal powder storehouse 1
The brace 9 of 1 sidewall slope of powder cabin, two braces 9 are symmetrical arranged about the axial line in medicinal powder storehouse 1.Flexible elongate tubular 2 is towards medicinal powder storehouse
1 one end is connected with cricoid card adapter plate 10, and card adapter plate 10 is provided with the clamping groove 11 passed through for brace 9, works as clamping
Plate 10 towards brace 9 trust it is mobile after, card adapter plate 10 will squeeze brace 9 until brace 9 is in the opening of clamping groove 11, with
Brace 9 will pass through clamping groove 11 and then flexible elongate tubular 2 and medicinal powder storehouse 1 is allowed to realize the purpose being clamped afterwards.Flexible elongate tubular 2 deviates from medicine
The direction integrally connected of powder cabin 1 slidably connects mobile bar 6 in each fixed plate 5 there are two having the fixed plate 5 being open, more
A mobile bar 6 is connected with the same closed plate 8 for closing flexible long tube 2 jointly.Mobile bar 6 and fixed plate 5 are respectively set
There is the magnetic patch 7 that can be attracted each other.The side of closed plate 8 towards flexible elongate tubular 2 is connected with the first guide plate 14, and flexibility is long
The side of pipe 2 towards closed plate 8 is connected with the second guide plate 15 with 14 can of the first guide plate.Flexible elongate tubular 2 is separate
The one end in medicinal powder storehouse 1 is fixedly connected with jet tray 16, and jet tray 16 is capable of the opening of closing flexible long tube 2, jet tray 16 just
Multiple spray-holes for implementing jet tray 16 are provided with, drug can be pierced by arrival agents area from spray-hole.Jet tray 16 with
Fixed plate 5 is fixedly connected by connecting rope 17.After length direction deformation of the compression bin 3 along itself, internal sky can be squeezed
Gas pushes closed plate 8 to push air into medicinal powder storehouse 1 and then bring the medicinal powder in medicinal powder storehouse 1 in flexible elongate tubular 2 into
The purpose for realizing that medicinal powder is projected from spray-hole is separated with flexible elongate tubular 2.
Embodiment 1:
Including the suck-back-prevention type chemical spraying device that above-mentioned cooperation endoscope uses, wherein flexible hose according to parts by weight, including such as
Lower component: 60 parts of halloysite nanotubes, 10 parts of chlorhexidine gluconate, 5 parts of nano silver, 100 parts of polypropylene.
The preparation method of above-mentioned halloysite nanotubes is step 1: according to parts by weight, weighing chlorhexidine gluconate 10
Part, formation chlorhexidine gluconate saturated solution soluble in water；
Step 2: according to parts by weight, weigh 60 parts of halloysite nanotubes, and using vacuum suction mode by gluconic acid chlorine oneself
Surely it sucks in halloysite nanotubes；
Step 3: using magnetic agitation under vacuum conditions, and maintain 30-60min, then restore the chamber pressure of 10pa；
Step 4: the process of step 3 is repeated 2-3 times；
Step 5: the suspension that step 4 obtains being centrifuged 10min under the conditions of 9000r/min, then cleans 2 with deionized water
It is secondary, and in 50 DEG C of drying in oven, obtain head product；
Step 6: 5 parts of nano silver being added according to parts by weight, in the head product obtained in steps of 5 and radiates 30- in UV
Modified halloysite nanotubes can be obtained in 70min.
Embodiment 2: the suck-back-prevention type chemical spraying device used including above-mentioned cooperation endoscope, wherein flexible hose is according to weight
Number, including following component: 65 parts of halloysite nanotubes, 11 parts of chlorhexidine gluconate, 6 parts of nano silver, 110 parts of polypropylene.
The preparation method of above-mentioned halloysite nanotubes is step 1: according to parts by weight, weighing chlorhexidine gluconate 11
Part, formation chlorhexidine gluconate saturated solution soluble in water；
Step 2: according to parts by weight, weigh 65 parts of halloysite nanotubes, and using vacuum suction mode by gluconic acid chlorine oneself
Surely it sucks in halloysite nanotubes；
Step 3: using magnetic agitation under vacuum conditions, and maintain 30-60min, then restore the chamber pressure of 10pa；
Step 4: the process of step 3 is repeated 2-3 times；
Step 5: the suspension that step 4 obtains being centrifuged 10min under the conditions of 9000r/min, then cleans 2 with deionized water
It is secondary, and in 50 DEG C of drying in oven, obtain head product；
Step 6: 6 parts of nano silver being added according to parts by weight, in the head product obtained in steps of 5 and radiates 30- in UV
Modified halloysite nanotubes can be obtained in 70min.
Embodiment 3: the suck-back-prevention type chemical spraying device used including above-mentioned cooperation endoscope, wherein flexible hose is according to weight
Number, including following component: 70 parts of halloysite nanotubes, 12.5 parts of chlorhexidine gluconate, 6.5 parts of nano silver, polypropylene 125
Part.
The preparation method of above-mentioned halloysite nanotubes is step 1: according to parts by weight, weighing chlorhexidine gluconate 12.5
Part, formation chlorhexidine gluconate saturated solution soluble in water；
Step 2: according to parts by weight, weigh 70 parts of halloysite nanotubes, and using vacuum suction mode by gluconic acid chlorine oneself
Surely it sucks in halloysite nanotubes；
Step 3: using magnetic agitation under vacuum conditions, and maintain 30-60min, then restore the chamber pressure of 10pa；
Step 4: the process of step 3 is repeated 2-3 times；
Step 5: the suspension that step 4 obtains being centrifuged 10min under the conditions of 9000r/min, then cleans 2 with deionized water
It is secondary, and in 50 DEG C of drying in oven, obtain head product；
Step 6: 6.5 parts of nano silver being added according to parts by weight, in the head product obtained in steps of 5 and radiates 30- in UV
Modified halloysite nanotubes can be obtained in 70min.
Embodiment 4: the suck-back-prevention type chemical spraying device used including above-mentioned cooperation endoscope, wherein flexible hose is according to weight
Number, including following component: 75 parts of halloysite nanotubes, 14 parts of chlorhexidine gluconate, 7 parts of nano silver, 140 parts of polypropylene.
The preparation method of above-mentioned halloysite nanotubes is step 1: according to parts by weight, weighing chlorhexidine gluconate 14
Part, formation chlorhexidine gluconate saturated solution soluble in water；
Step 2: according to parts by weight, weigh 75 parts of halloysite nanotubes, and using vacuum suction mode by gluconic acid chlorine oneself
Surely it sucks in halloysite nanotubes；
Step 3: using magnetic agitation under vacuum conditions, and maintain 30-60min, then restore the chamber pressure of 10pa；
Step 4: the process of step 3 is repeated 2-3 times；
Step 5: the suspension that step 4 obtains being centrifuged 10min under the conditions of 9000r/min, then cleans 2 with deionized water
It is secondary, and in 50 DEG C of drying in oven, obtain head product；
Step 6: nano silver 5-8 parts being added according to parts by weight, in the head product obtained in steps of 5 and radiates 30- in UV
Modified halloysite nanotubes can be obtained in 70min.
Embodiment 5: the suck-back-prevention type chemical spraying device used including above-mentioned cooperation endoscope, wherein flexible hose is according to weight
Number, including following component: 80 parts of halloysite nanotubes, 15 parts of chlorhexidine gluconate, 8 parts of nano silver, 150 parts of polypropylene.
The preparation method of above-mentioned halloysite nanotubes is step 1: according to parts by weight, weighing chlorhexidine gluconate 15
Part, formation chlorhexidine gluconate saturated solution soluble in water；
Step 2: according to parts by weight, weigh 80 parts of halloysite nanotubes, and using vacuum suction mode by gluconic acid chlorine oneself
Surely it sucks in halloysite nanotubes；
Step 3: using magnetic agitation under vacuum conditions, and maintain 30-60min, then restore the chamber pressure of 10pa；
Step 4: the process of step 3 is repeated 2-3 times；
Step 5: the suspension that step 4 obtains being centrifuged 10min under the conditions of 9000r/min, then cleans 2 with deionized water
It is secondary, and in 50 DEG C of drying in oven, obtain head product；
Step 6: 8 parts of nano silver being added according to parts by weight, in the head product obtained in steps of 5 and radiates 30- in UV
Modified halloysite nanotubes can be obtained in 70min.
Comparative example 1: the difference with embodiment 3 is removal polypropylene, remaining is same as Example 3.
Test experiments:
Inhibition zone test is carried out according to " disinfection technology standard " 2002No2.1.8.2.Test strain: Escherichia coli 8099.
It is that the high-temperature sterilization standby of 7mm filter paper dick is used as comparative example 2 by diameter, respectively impregnates the filter paper after sterilizing
Embodiment 1-5 is weighed according to identical weight number, is placed in the culture dish for being coated with 200 μ L bacterium solutions, is placed in 37 in incubator
DEG C culture 30d, then observes the condition of production of bacterium and tests the size of inhibition zone, and test result is as shown in table 1,
Table 1 is the performance table of embodiment 1-5, comparative example 1-2 bacterial concentration in different time periods and antibacterial circle diameter
The antibacterial time of the proportion of available embodiment 3 is optimum proportioning at most from table 1, and by comparative example 1 and is implemented
Example 3 is it can be found that after removal polypropylene, and the antibacterial time of comparative example 1 declines, this is because glucose under the action of polypropylene
Sour Chlorhexidine and nano silver can be uniformly distributed in halloysite nanotubes, in conjunction with more closely and capable of allowing halloysite nanotubes
Sustained release time extend, increase antibacterial use the time.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to restrict the invention, all in design structure of the invention
Within think of, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of suck-back-prevention type chemical spraying device that cooperation endoscope uses, the medicinal powder storehouse (1) including being set as hollow form, feature
Be: one end of the medicinal powder storehouse (1) is connected with flexible elongate tubular (2), and the other end of the medicinal powder storehouse (1) is threaded with can deformation
Compression bin (3), one end of medicinal powder storehouse (1) towards the compression bin (3) is provided with porous membrane (4), the flexible elongate tubular (2)
It is connected with the fixed plate (5) with opening away from the direction of medicinal powder storehouse (1), the fixed plate (5) slidably connects movement
Bar (6), the mobile bar (6) and fixed plate (5) are respectively arranged with the magnetic patch (7) to attract each other, and the mobile bar (6) integrally connects
It is connected to the closed plate (8) for closing flexible long tube (2).
2. a kind of suck-back-prevention type chemical spraying device that cooperation endoscope uses according to claim 1, it is characterized in that: the medicine
The side wall of powder cabin (1) is connected with the more braces (9) with medicinal powder storehouse (1) sidewall slope, and the flexible elongate tubular (2) is towards medicine
One end of powder cabin (1) is connected with cricoid card adapter plate (10), and the card adapter plate (10) is provided with to be passed through for brace (9)
Clamping groove (11).
3. a kind of suck-back-prevention type chemical spraying device that cooperation endoscope uses according to claim 1, it is characterized in that: described soft
Property long tube (2) far from the one end of medicinal powder storehouse (1) be set as horn-like.
4. a kind of suck-back-prevention type chemical spraying device that cooperation endoscope uses according to claim 1, it is characterized in that: the pressure
Contracting storehouse (3) is provided with multiple recirculation holes (12) far from the one end of medicinal powder storehouse (1), is fixedly connected with reply in the compression bin (3)
Spring (13).
5. a kind of suck-back-prevention type chemical spraying device that cooperation endoscope uses according to claim 2, it is characterized in that: described oblique
Bar (9) is set as two.
6. a kind of suck-back-prevention type chemical spraying device that cooperation endoscope uses according to claim 1, it is characterized in that: the envelope
The side of closing plate (8) towards flexible elongate tubular (2) is connected with the first guide plate (14), flexible elongate tubular (2) the direction closing
The side of plate (8) is connected with the second guide plate (15) being bonded with the first guide plate (14).
7. a kind of suck-back-prevention type chemical spraying device that cooperation endoscope uses according to claim 1, it is characterized in that: described soft
Property long tube (2) according to parts by weight, including following component: 60-80 parts of halloysite nanotubes, 10-15 parts of chlorhexidine gluconate,
5-8 parts of nano silver, 100-150 parts of polypropylene.
8. a kind of method of modifying of halloysite nanotubes as claimed in claim 7, it is characterized in that:
Step 1: according to parts by weight, weighing 10-15 parts of chlorhexidine gluconate, formation chlorhexidine gluconate soluble in water is full
And solution；
Step 2: according to parts by weight, weighing 60-80 parts of halloysite nanotubes, and use vacuum suction mode by gluconic acid chlorine
Oneself sucks in halloysite nanotubes surely；
Step 3: using magnetic agitation under vacuum conditions, and maintain 30-60min, then restore the chamber pressure of 10pa；
Step 4: the process of step 3 is repeated 2-3 times；
Step 5: the suspension that step 4 obtains being centrifuged 10min under the conditions of 9000r/min, then cleans 2 with deionized water
It is secondary, and in 50 DEG C of drying in oven, obtain head product；
Step 6: nano silver 5-8 parts being added according to parts by weight, in the head product obtained in steps of 5 and continues under uv radiation
30-70min, and be added 100-150 parts of polypropylene and modified halloysite nanotubes can be obtained.
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| CN201810995523.2A CN109200445A (en) | 2018-08-29 | 2018-08-29 | A kind of suck-back-prevention type chemical spraying device that cooperation endoscope uses |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI759076B (en) * | 2021-01-15 | 2022-03-21 | 陳映臻 | Medicine delivery device for healing body cavity wound and medicine delivery duct thereof |
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