CN109675084A - Antiseptic dressing and its preparation method and application - Google Patents
Antiseptic dressing and its preparation method and application Download PDFInfo
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- CN109675084A CN109675084A CN201811545144.XA CN201811545144A CN109675084A CN 109675084 A CN109675084 A CN 109675084A CN 201811545144 A CN201811545144 A CN 201811545144A CN 109675084 A CN109675084 A CN 109675084A
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- dressing
- nanometer silver
- antiseptic dressing
- silver peroxide
- antiseptic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Abstract
The present invention provides a kind of antiseptic dressings and its preparation method and application, are related to medical dressing technical field.The antiseptic dressing includes dressing carrier and nanometer silver peroxide, dressing carrier is the micro/nano fiber structure that water soluble polymer is formed, nanometer silver peroxide is distributed in inside dressing carrier and/or surface, wherein, the nanometer silver peroxide of high-valence state is for soluble silver salt and nano silver, with more preferably antibacterial effect, and its insoluble guarantees that its is not soluble in water, will not enter human body with body fluid；In addition, the micro/nano fiber structure of dressing carrier makes it have higher specific surface area, therefore when contact body fluid, its nanometer silver peroxide loaded has more contact bacterium chances, to reach better antibacterial effect with lower dosage, cost is reduced, is further ensured that biological safety.The present invention also provides the preparation method of above-mentioned antiseptic dressing, simple process, stabilization are suitable for industrialized production.
Description
Technical field
The present invention relates to medical dressing technical fields, in particular to a kind of antiseptic dressing and preparation method thereof and answer
With.
Background technique
Common silver-series antibacterial agent is mostly soluble silver salt and nano silver in the market, is made with stronger broad-spectrum antiseptic
With, can be used as the preparation that antimicrobial component is widely used in function wound dressing, be cope with large area wound infection common treatment
Product.
But there are some defects in soluble silver salt and nano silver, for example, soluble silver salt property is unstable, exists and see
The problems such as photodegradation or discoloration；And nano silver higher operating costs；In addition, soluble silver salt and nano silver all have good water
Dissolubility exists and is dissolved in the risk that body fluid enters human body, has certain problems in terms of biological safety.Drawbacks described above is not
With degree hinder the large-scale application of soluble silver salt and nano silver.
In view of this, the present invention is specifically proposed at least one of to solve the above technical problems.
Summary of the invention
The first purpose of this invention is to provide a kind of antiseptic dressing, passes through nanometer silver peroxide and dressing carrier knot
It closes, so that the antiseptic dressing antibacterial characteristics are excellent, when being applied to skin ultrastructure, there is good anti-wound infection ability.
Second object of the present invention is to provide a kind of preparation method of antiseptic dressing, the preparation method simple process,
It operates conveniently, is suitble to industrial large-scale production.
Third object of the present invention is to provide the application of above-mentioned antiseptic dressing.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
The present invention provides a kind of antiseptic dressings, comprising:
Dressing carrier, the micro/nano fiber structure formed for water soluble polymer；With,
Nanometer silver peroxide is distributed in the dressing carrier inside and/or surface.
Further, on the basis of technical solution of the present invention, the nanometer silver peroxide is in the antiseptic dressing
Solid content be 0.05-12wt%, preferably 1-10wt%；
And/or the nanometer silver peroxide be laminated structure, it is preferable that the nanometer silver peroxide with a thickness of 1-
20nm, length or width independently are 500nm-2 μm.
Further, on the basis of technical solution of the present invention, the water soluble polymer includes polyvinyl alcohol, poly- second
Any one in vinyl pyrrolidone, poly- methylcellulose, polyacrylic acid, polyethylene glycol oxide, polylactic acid, chitosan or gelatin
Or at least two combination, preferably polyvinyl alcohol.
Further, on the basis of technical solution of the present invention, the micro/nano fiber structure of the dressing carrier formation
Diameter be 100nm-1 μm, preferably 150-900nm.
The present invention also provides the preparation methods of above-mentioned antiseptic dressing, comprising the following steps:
The mixed solution that nanometer silver peroxide and water soluble polymer are formed is subjected to electrostatic spinning, obtains antiseptic dressing.
Further, on the basis of technical solution of the present invention, nanometer silver peroxide is formed with water soluble polymer
Thickener soln is also added in mixed solution, the thickener of the thickener soln accounts for the quality volume of the thickener soln
Than for 0.5-2%, preferably 1-1.5%；
Preferably, the thickener includes sodium carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, alginic acid
In sodium, polyvinyl alcohol, polyacrylic acid or polyethylene glycol oxide any one or at least two combination.
Further, on the basis of technical solution of the present invention, the technological parameter of electrostatic spinning includes: that spinning voltage is
12-18kV；And/or mixed solution flow velocity is 0.5-1.5mL/min；And/or receiving distance is 5-15cm.
Further, on the basis of technical solution of the present invention, the preparation method of the nanometer silver peroxide include with
Lower step:
Persulfate, highly basic, surfactant and inorganic soluble silver salt are mixed and carried out precipitation reaction, will be reacted
The sediment separation arrived, obtains a nanometer silver peroxide.
Further, on the basis of technical solution of the present invention, the persulfate includes potassium peroxydisulfate and/or over cure
Sour sodium；
And/or the inorganic soluble silver salt includes silver nitrate and/or silver acetate；
And/or the highly basic includes sodium hydroxide or potassium hydroxide；
And/or the surfactant is ionic surface active agent, it is preferable that the ionic surface active agent is alkyl
Sulfonate or alkyl sulfate, preferably lauryl sodium sulfate, myristyl sodium sulfonate, sodium cetanesulfonate or dodecane
In base benzene sulfonic acid sodium salt any one or at least two combination.
Antiseptic dressing made from preparation method the present invention also provides above-mentioned antiseptic dressing or using antiseptic dressing is in life
Application in object field of medicaments.
Compared with prior art, antiseptic dressing provided by the invention and preparation method thereof has the advantages that
(1) the present invention provides a kind of antiseptic dressing, including dressing carrier and nanometer silver peroxide, dressing carrier is water-soluble
Property the micro/nano fiber structure that is formed of macromolecule, nanometer silver peroxide is distributed in inside dressing carrier and/or surface, wherein high
The nanometer silver peroxide of valence state has more preferably antibacterial effect for soluble silver salt and nano silver, and its is insoluble
Property guarantees that its is not soluble in water, will not enter human body with body fluid；In addition, the micro/nano fiber structure of dressing carrier makes it have more
High specific surface area, therefore when contact body fluid, the nanometer silver peroxide of load has more contact bacterium chances, thus with
Lower dosage reaches better antibacterial effect, reduces cost.
(2) preparation method of antiseptic dressing provided by the invention, simple process, stabilization, is suitable for industrialized production.
(3) antibacterial made from the preparation method the present invention provides above-mentioned antiseptic dressing or using above-mentioned antiseptic dressing is applied
The application of material.In view of advantage possessed by above-mentioned antiseptic dressing, so that it, which repairs field in skin wound, has good application.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is the outside drawing for the nanometer silver peroxide that the embodiment of the present invention 3 provides；
Fig. 2 is the SEM electron microscope for the silver peroxide that comparative example 3 of the present invention provides；
Fig. 3 is the SEM electron microscope for the nanometer silver peroxide that the embodiment of the present invention 3 provides；
Fig. 4 is the SEM electron microscope for the dressing carrier that the embodiment of the present invention 3 provides；
Fig. 5 is the SEM electron microscope for the antiseptic dressing that the embodiment of the present invention 3 provides；
Fig. 6 is the bacterial growth situation map for the antiseptic dressing that blank control and embodiment 3 provide in the present invention.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to the first aspect of the invention, a kind of antiseptic dressing is provided, comprising:
Dressing carrier, the micro/nano fiber structure formed for water soluble polymer；With,
Nanometer silver peroxide is distributed in dressing carrier inside and/or surface.
Dressing carrier is mainly used to protect the exposed surface of a wound, and promotes the reparation of tissue.With the gauze dressing of traditional class
Carrier is different, and dressing carrier is mainly made of water soluble polymer in the present invention.Containing a large amount of in water soluble polymer
Hydroxyl can form a large amount of hydrogen bonds with hydrone, and therefore, obtained dressing carrier can absorb moisture, provide for wound healing
The environment of wetting, but the chance for also resulting in wound circumference bacterial infection simultaneously increases, therefore in order to enhance the antibacterial of dressing carrier
Property, it needs to load some antibacterial materials on dressing carrier.
In the present invention, antibacterial material is nanometer silver peroxide.Nanometer silver peroxide is not soluble in water, and antibacterial mechanisms are to connect
Touch sterilization, oxidation electric discharge, kills bacterium when the silver of high-valence state contacts bacterium.Relative to soluble silver salt and nano silver, high price
The nanometer silver peroxide of state has a more preferably antibacterial effect, and its it is insoluble guarantee that its is not soluble in water, will not with body fluid into
Enter human body.
It should be noted that heretofore described " micro/nano fiber structure " just refer to dressing carrier in micron and/or
Nanofibrous structures.Nanometer silver peroxide is supported on the surface and/or inside of micro/nano fiber structure, can effectively reduce a nanometer mistake
Silver oxide falls off and reunites.Meanwhile above-mentioned micro/nano fiber structure has higher specific surface area, therefore when contact body fluid,
Its nanometer silver peroxide loaded has more contact bacterium chances, to reach better antibacterial effect with lower dosage
Fruit can reduce cost.
By the load nanometer silver peroxide on dressing carrier, nanometer silver peroxide is combined together with dressing carrier,
While keeping original dressing carrier function, so that the nanometer silver peroxide in dressing carrier plays antibacterial and bacteriostasis,
Mitigate surface of a wound local infection, improves the microenvironment of surface of a wound part, promote the healing of wound.
It should be further noted that antiseptic dressing provided by the invention can further include drug ingedient, such as
Lidocaine with antiinflammation has quickly dispel pain, Chinese herbal medicine active constituent of hemostasis and anti-inflammation function etc..By drug ingedient
It is combined with dressing carrier, has the protection surface of a wound, analgesic, hemostasis, anti-inflammatory, promotes new granulation tissue and epithelial cell growth, add
The functions such as fast wound healing.
As a kind of optional embodiment of the invention, solid content of the nanometer silver peroxide in antiseptic dressing is 0.05-
12wt%, preferably 1-10wt%；
Nanometer silver peroxide typical but non-limiting solid content in antiseptic dressing be, for example, 0.05wt%, 0.1wt%,
1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt%, 11wt% or 12wt%.
By the restriction to nanometer silver peroxide content, so that the antiseptic dressing is guaranteeing excellent anti-microbial property premise
Under, there is less silver peroxide additive amount.
As a kind of optional embodiment of the invention, nanometer silver peroxide is laminated structure, it is preferable that nanometer peroxidating
Silver with a thickness of 1-20nm, length or width independently is 500nm-2 μm.
The nanometer silver peroxide specific surface area with higher of laminated structure, when application, can increase the contact machine with bacterium
Meeting, can also be more uniform be distributed in dressing carrier.Nanometer silver peroxide it is typical but non-limiting with a thickness of 1nm, 2nm,
5nm, 6nm, 8nm, 10nm, 12nm, 14nm, 15nm, 16nm, 18nm or 20nm, nanometer silver peroxide are typical but non-limiting
Length or width is 500nm, 600nm, 700nm, 800nm, 900nm, 1 μm, 1.5 μm or 2 μm.
The type for being used to form the water soluble polymer of dressing carrier has very much.As a kind of optional embodiment party of the invention
Formula, water soluble polymer include polyvinyl alcohol, polyvinylpyrrolidone, poly- methylcellulose, polyacrylic acid, polyoxyethylene
In alkene, polylactic acid, chitosan or gelatin any one or at least two combination, preferably polyvinyl alcohol.
Wherein, polyvinyl alcohol has good biocompatibility, makees to body and histocyte without any toxicity and stimulation
With, it is made into dressing carrier, film is formed on the skin surfaces such as wound and wound, is conducive to the protection to wound surface skin,
And the nanometer silver peroxide for being supported on dressing carrier surface and inside also has good antibiotic property, and wound musculus cutaneus can be effectively suppressed
The bacterium infection of skin.
The diameter for the micro/nano fiber structure that dressing carrier is formed is not particularly limited, as long as its diameter is in micron
Scale or nanoscale.The micro nanometer fiber knot formed as a kind of optional embodiment of the invention, dressing carrier
The diameter of structure is 100nm-1 μm, preferably 150-900nm.The typical but non-limiting diameter of dressing carrier be 100nm,
150nm, 200nm, 300nm, 500nm, 600nm, 800nm, 900nm or 1000nm.
According to the second aspect of the invention, the preparation method of above-mentioned antiseptic dressing is additionally provided, comprising the following steps:
The mixed solution that nanometer silver peroxide and water soluble polymer are formed is subjected to electrostatic spinning, obtains antiseptic dressing.
Electrostatic spinning typically refers to load high-pressure electrostatic in polymer solution or melt, fine to obtain nanometer or sub-micron
A kind of technology of dimension, the electrospinning fibre of acquisition has the diameter of nanometer or sub-micrometer scale, great surface area and porosity, non-
The growth of normal suitable cell and tissue, is conducive to the load of nanometer silver peroxide.
It in the present invention, is exactly to be mixed using nanometer silver peroxide as antibacterial agent with water-soluble polymer solution etc., will
The mixed solution arrived carries out electrostatic spinning, and nanometer silver peroxide is made and is supported on micro/nano fiber structure inside and/or table
On the dressing carrier in face, by the compound of nanometer silver peroxide and both dressing carriers, the antiseptic dressing of good anti-bacterial effect is obtained.
As a kind of optional embodiment of the invention, the mixed solution of nanometer silver peroxide and water soluble polymer formation
In also be added with thickener soln.It is molten that thickener is added in the mixed solution formed to nanometer silver peroxide with water soluble polymer
Liquid is conducive to nanometer silver peroxide and mixes with water soluble polymer more uniformly.
The dosage of thickener should not be excessive in thickener soln.As a kind of optional embodiment of the invention, thickener
The mass volume ratio for accounting for thickener soln is 0.5-2%, preferably 1-1.5%.Typical but non-limiting mass volume ratio is
0.5%, 0.8%, 1.0%, 1.2%, 1.4%, 1.5%, 1.6%, 1.8% or 2.0%.
As a kind of optional embodiment of the invention, thickener includes sodium carboxymethylcellulose, hydroxyethyl cellulose, hydroxyl
In propyl cellulose, sodium alginate, polyvinyl alcohol, polyacrylic acid or polyethylene glycol oxide any one or at least two group
It closes.
By the restriction of thickener type and dosage in the thickener soln to addition, so that nanometer silver peroxide is mixed
It is more uniform to close dispersion in solution.
The technological parameter of electrostatic spinning need to require to be configured according to mixed solution and actual product.As of the invention
A kind of optional embodiment, the technological parameter of electrostatic spinning include: that spinning voltage is 12-18kV；And/or mixed solution flow velocity
For 0.5-1.5mL/min；And/or receiving distance is 5-15cm.
Wherein, typical but non-limiting spinning voltage be 12kV, 14kV, 15V, 16V or 18V, it is typical but non-limiting
Mixed solution flow velocity be 0.5mL/min, 0.6mL/min, 0.7mL/min, 0.8mL/min, 1.0mL/min, 1.2mL/min,
1.4mL/min or 1.5mL/min.
Receiving distance refers to spinning head the distance between to receiver board.Typical but non-limiting reception distance be 5cm,
6cm, 8cm, 10cm, 12cm, 14cm or 15cm.
By the specific restriction to electrostatic spinning process parameter, so that obtained antiseptic dressing is with good micro-nano
Fiber membrane structure.
Nanometer silver peroxide is commercially available, can also voluntarily prepare.As a kind of optional embodiment of the invention, nanometer mistake
The preparation method of silver oxide the following steps are included:
Persulfate, highly basic, surfactant and inorganic soluble silver salt are mixed and carried out precipitation reaction, will be reacted
The sediment separation arrived, obtains a nanometer silver peroxide.
As a kind of optional embodiment of the invention, persulfate includes potassium peroxydisulfate and/or sodium peroxydisulfate；
And/or inorganic soluble silver salt includes silver nitrate and/or silver acetate；
And/or highly basic includes sodium hydroxide and/or potassium hydroxide；
And/or surfactant is ionic surface active agent, it is preferable that ionic surface active agent be alkylsulfonate or
Alkyl sulfate, preferably lauryl sodium sulfate, myristyl sodium sulfonate, sodium cetanesulfonate or dodecyl benzene sulfonic acid
In sodium any one or at least two combination.
By to persulfate, highly basic, surfactant and the specific kind of restriction of inorganic soluble silver salt, so that made
Nanometer silver peroxide is with good performance and pattern.
As a kind of optional embodiment of the invention, the preparation method of nanometer silver peroxide the following steps are included:
First persulfate and highly basic are mixed, surfactant is then added and is mixed, by persulfate, highly basic and
The mixed liquor of surfactant heats, and inorganic soluble silver salt is added to it and carries out precipitation reaction, cools down after reaction, will be anti-
The sediment separation that should be obtained, obtains a nanometer silver peroxide.
By the restriction to charging sequence, so that nanometer silver peroxide distribution of particles obtained is more uniform, and have good
Good pattern, obtained nanometer silver peroxide structure in the form of sheets.
Preferably, a kind of typical preparation method of nanometer silver peroxide, comprising the following steps:
By 0.1~0.3mol Na2S2O850 DEG C are heated to 0.4~0.8mol NaOH to be slowly stirred to abundant dissolution；
0.005~0.05mol dodecyl sodium sulfate (Sodium laurylsulfonate, SDS) is added to reaction
In liquid, stirring is then heated to 60~65 DEG C, obtains mixed solution A to abundant dissolution；
By 0.1mol AgNO3It is dissolved in 300mL deionized water, is added slowly in above-mentioned mixed solution A (10~60min drop
Add complete), continue to be stirred to react 10~60min, finally stops heating, be cooled to room temperature, collected by suction precipitates and uses deionization
Water cleans (50mL × 5 time), and 50 DEG C dry 24 hours, obtains a nanometer silver peroxide.
By the restriction to nanometer silver peroxide preparation method specific steps and parameter, the nanometer silver peroxide that makes
Size distribution is more uniform, and nanometer silver peroxide pattern is more regular, and laminated structure is presented.
According to the third aspect of the present invention, above-mentioned antiseptic dressing or the preparation using above-mentioned antiseptic dressing are additionally provided
Application of the antiseptic dressing made from method in biomedicine field.
Biomedicine field may include skin wound reparation or skin wound treatment etc.." surface of a wound " therein is normal
Skin (tissue) is caused injury the factor such as surgical operation, external force, heat, electric current, chemical substance, low temperature and body internal factor in the external world
Damage caused by under the effects of supplying obstacle such as local blood is often accompanied by the destruction of skin integrity and normal group a certain amount of
The loss knitted, meanwhile, the normal function of skin is impaired.
Antiseptic dressing provided by the invention can be used separately as medical dressing, can also be with the dressing knot of other function
It is combined use.
In view of advantage possessed by above-mentioned antiseptic dressing, so that it is in skin wound reparation or healing art with good
Using.
Combined with specific embodiments below and comparative example, the invention will be further described.
Embodiment 1
A kind of antiseptic dressing provided in this embodiment, including dressing carrier and nanometer silver peroxide, dressing carrier are gelatin
The micro/nano fiber structure of formation, nanometer silver peroxide is distributed in inside dressing carrier and surface；
Nanometer silver peroxide be laminated structure, nanometer silver peroxide with a thickness of 1-5nm, length or width independently is
500-800nm, solid content of the nanometer silver peroxide in antiseptic dressing are 10wt%；
Dressing carrier is gelatin, and the diameter for the micro/nano fiber structure that dressing carrier is formed is 900nm.
The preparation method of antiseptic dressing provided by the embodiment, comprising the following steps:
(a) the nanometer silver peroxide particle of formula ratio is added to the carboxymethylcellulose sodium solution that concentration is 1%w/v
In, by ultrasound and vortex concussion processing to fully dispersed, obtain a nanometer silver peroxide solution；
(b) under magnetic agitation effect, nanometer silver peroxide solution is slowly dropped in gelatin solution, a nanometer peroxide is made
It is evenly dispersed to change silver, obtains mixed solution；Wherein, the mass-volume concentration of gelatin is 8% in gelatin solution；
(c) to mixed solution carry out electrostatic spinning, wherein spinning voltage 12kV, flow velocity 1.5mL/min, receive away from
From for 8cm, antiseptic dressing is obtained.
Embodiment 2
A kind of antiseptic dressing provided in this embodiment, including dressing carrier and nanometer silver peroxide, dressing carrier are poly- second
The micro/nano fiber structure that vinyl pyrrolidone is formed, nanometer silver peroxide is distributed in inside dressing carrier and surface；
Nanometer silver peroxide be laminated structure, nanometer silver peroxide with a thickness of 8-10nm, length or width is independently
For 800-1000nm, solid content of the nanometer silver peroxide in antiseptic dressing is 1wt%；
Dressing carrier is gelatin, and the diameter for the micro/nano fiber structure that dressing carrier is formed is 1 μm.
The preparation method of antiseptic dressing provided by the embodiment, comprising the following steps:
(a) the nanometer silver peroxide particle of formula ratio is added to the carboxymethylcellulose sodium solution that concentration is 0.5%w/v
In, by ultrasound and vortex concussion processing to fully dispersed, obtain a nanometer silver peroxide solution；
(b) magnetic agitation effect under, by nanometer silver peroxide solution be slowly dropped to for polyvinylpyrrolidone it is molten
In liquid, keeps nanometer silver peroxide evenly dispersed, obtain mixed solution；Wherein, polyvinyl in polyvinylpyrrolidone solution
The mass-volume concentration of pyrrolidones is 9%；
(c) to mixed solution carry out electrostatic spinning, wherein spinning voltage 15kV, flow velocity 1.0mL/min, receive away from
From for 12cm, antiseptic dressing is obtained.
Embodiment 3
A kind of antiseptic dressing provided in this embodiment, including dressing carrier and nanometer silver peroxide, dressing carrier are poly- second
The micro/nano fiber structure that enol is formed, nanometer silver peroxide is distributed in inside dressing carrier and surface；
Nanometer silver peroxide be laminated structure, nanometer silver peroxide with a thickness of 10-11nm, length or width is independently
For 800-1000nm, solid content of the nanometer silver peroxide in antiseptic dressing is 0.1wt%；
Dressing carrier is polyvinyl alcohol, and the diameter for the micro/nano fiber structure that dressing carrier is formed is 1 μm.
The preparation method of antiseptic dressing provided by the embodiment, comprising the following steps:
(a) the nanometer silver peroxide particle of formula ratio is added to the carboxymethylcellulose sodium solution that concentration is 1%w/v
In, by ultrasound and vortex concussion processing to fully dispersed, obtain a nanometer silver peroxide solution；
(b) under magnetic agitation effect, nanometer silver peroxide solution is slowly dropped in poly-vinyl alcohol solution, to make to receive
Rice silver peroxide is evenly dispersed, obtains mixed solution；
(c) to mixed solution carry out electrostatic spinning, wherein spinning voltage 18kV, flow velocity 0.6mL/min, receive away from
From for 15cm, antiseptic dressing is obtained.
Embodiment 4
A kind of antiseptic dressing provided in this embodiment, in addition to solid content of the nanometer silver peroxide in antiseptic dressing is
1wt%, remaining is same as Example 3.
The preparation method of antiseptic dressing provided in this embodiment is same as Example 3.
Embodiment 5
A kind of antiseptic dressing provided in this embodiment, in addition to solid content of the nanometer silver peroxide in antiseptic dressing is
10wt%, remaining is same as Example 3.
The preparation method of antiseptic dressing provided in this embodiment is same as Example 3.
Embodiment 6
A kind of antiseptic dressing provided in this embodiment, in addition to solid content of the nanometer silver peroxide in antiseptic dressing is
0.05wt%, remaining is same as Example 3.
The preparation method of antiseptic dressing provided in this embodiment is same as Example 3.
Embodiment 7
A kind of antiseptic dressing provided in this embodiment, in addition to dressing carrier is chitosan, remaining is same as Example 3.
The preparation method of antiseptic dressing provided in this embodiment is same as Example 3.
Embodiment 8
A kind of antiseptic dressing provided in this embodiment, in addition to the diameter of the micro/nano fiber structure of dressing carrier formation is
200nm, remaining is same as Example 3.
The preparation method of antiseptic dressing provided in this embodiment is same as Example 3.
In above-described embodiment 1-7 in antiseptic dressing raw material nanometer silver peroxide preparation method, comprising the following steps:
(a) by 0.3mol Na2S2O8, 0.7mol NaOH and 0.0059mol SDS be added 1200mL deionized water in, add
Heat, which is slowly stirred to 50 DEG C to abundant, dissolves (clear), is then heated to 60~65 DEG C, obtains mixed solution A；
(b) by 0.1mol AgNO3It is dissolved in 300mL deionized water, is added slowly in above-mentioned mixed solution A (drip within 30 minutes
Add complete), continue to be stirred to react 30 minutes, finally stop heating, be cooled to room temperature, collected by suction precipitating is simultaneously clear with deionized water
It washes (50mL × 5), 50 DEG C dry 24 hours, obtain a nanometer silver peroxide.
Embodiment 9
A kind of antiseptic dressing provided in this embodiment, including dressing carrier and nanometer silver peroxide, dressing carrier are poly- second
The micro/nano fiber structure that enol is formed, nanometer silver peroxide is distributed in inside dressing carrier and surface；
Nanometer silver peroxide be laminated structure, nanometer silver peroxide with a thickness of 10-11nm, length or width is independently
For 800-1000nm, solid content of the nanometer silver peroxide in antiseptic dressing is 0.1wt%；
Dressing carrier is polyvinyl alcohol, and the diameter for the micro/nano fiber structure that dressing carrier is formed is 1.2 μm.
The preparation method of antiseptic dressing provided by the embodiment, comprising the following steps:
(a) the nanometer silver peroxide particle of formula ratio is added in the sodium alginate soln that concentration is 1%w/v, is passed through
Ultrasound and vortex concussion processing obtain a nanometer silver peroxide solution to fully dispersed；
(b) under magnetic agitation effect, nanometer silver peroxide solution is slowly dropped in poly-vinyl alcohol solution, to make to receive
Rice silver peroxide is evenly dispersed, obtains mixed solution；
(c) to mixed solution carry out electrostatic spinning, wherein spinning voltage 20kV, flow velocity 1.0mL/min, receive away from
From for 12cm, antiseptic dressing is obtained.
Embodiment 10
A kind of antiseptic dressing provided in this embodiment, in addition to nanometer silver peroxide is with a thickness of 10-11nm, length or width
It independently is 1.5-2 μm, remaining is same as Example 3.
The preparation method of antiseptic dressing provided in this embodiment is same as Example 3.
Wherein, the preparation method of nanometer silver peroxide, comprising the following steps:
(a) by 0.3mol K2S2O8, 0.7mol KOH and 0.0059mol SDS be added 1200mL deionized water in, heating
It is slowly stirred to 50 DEG C to abundant dissolution (clear), is then heated to 60~65 DEG C, obtains in mixed solution A；
(b) by 0.1mol C2H3AgO2It is dissolved in 300mL deionized water, is added slowly in above-mentioned mixed solution A (20 minutes
It is added dropwise), continue to be stirred to react 30 minutes, finally stops heating, be cooled to room temperature, collected by suction precipitates and uses deionized water
It cleans (50mL × 5), 50 DEG C dry 24 hours, obtain a nanometer silver peroxide.
Comparative example 1
This comparative example provides a kind of antiseptic dressing, in addition to nanometer silver peroxide is replaced with nano silver, remaining and implementation
Example 3 is identical.
The preparation method for the antiseptic dressing that this comparative example provides is same as Example 3.
Comparative example 2
This comparative example provides a kind of antiseptic dressing, in addition to nanometer silver peroxide is replaced with silver nitrate, remaining and implementation
Example 3 is identical.
The preparation method for the antiseptic dressing that this comparative example provides is same as Example 3.
Comparative example 3
This comparative example provides a kind of antiseptic dressing, in addition to nanometer silver peroxide is replaced with a micron silver peroxide, peroxide
The size for changing silver is 1~10 μm, remaining is same as Example 3.
The preparation method for the antiseptic dressing that this comparative example provides is same as Example 3.
Comparative example 4
This comparative example provides a kind of antiseptic dressing, in addition to dressing carrier is polyvinyl alcohol hydrogel, remaining and embodiment 3
It is identical.
The preparation method of polyvinyl alcohol hydrogel is prepared using conventional method in that art.
For the effect for further verifying above-described embodiment and comparative example, ad hoc following experimental example.
Experimental example 1
The anti-microbial property for the antiseptic dressing that embodiment 1-10 and comparative example 1-4 is provided is detected with the eradicative rate of bacterium.
The antibiotic property that method examines antiseptic dressing is resuspended using bacterium, method particularly includes: first by 10 μ L bacterial suspension (concentration
It is 1 × 109CFU it) is added drop-wise on the circular shaped bandages that diameter is 6.4mm, co-cultures 2 hours；Then with the phosphate-buffered salt of sterilizing
Remaining bacterium is resuspended in solution (PBS solution), is applied on agar bacteria culture media, cultivates 24 hours；Finally carry out
Plate is taken pictures, and bacterial growth situation is observed；Wherein, bacterium is Escherichia coli (E.coli) and staphylococcus aureus
(S.aureus), concrete outcome is as shown in table 1.
The anti-microbial property for the antiseptic dressing that each embodiment and comparative example of table 1 provides
| Serial number | Escherichia coli eradicative rate | Golden yellow grape eradicative rate |
| Embodiment 1 | 100% | 100% |
| Embodiment 2 | 99.8% | 99.8% |
| Embodiment 3 | 97.4% | 95.2% |
| Embodiment 4 | 99.8% | 99.8% |
| Embodiment 5 | 100% | 100% |
| Embodiment 6 | 95.1% | 94.7% |
| Embodiment 7 | 97.1% | 95.7% |
| Embodiment 8 | 98.6% | 96.9% |
| Embodiment 9 | 96.8% | 94.8% |
| Embodiment 10 | 96.2% | 94.1% |
| Comparative example 1 | 86.5% | 84.6% |
| Comparative example 2 | 78.9% | 77.2% |
| Comparative example 3 | 94.5% | 92.6% |
| Comparative example 4 | 93.7% | 91.8% |
From table 1 it follows that the anti-microbial property using 1-10 of the embodiment of the present invention antiseptic dressing provided is obvious excellent
In comparative example.
Wherein, embodiment 4-8 is the control experiment of embodiment 3.It is received in antiseptic dressing it can be seen from data in table 1
The solid content of rice silver peroxide has larger impact to the anti-microbial property of antiseptic dressing.When the solid content of nanometer silver peroxide is lower than one
When fixed number value, then good antibacterial effect is not achieved, therefore the solid content of nanometer silver peroxide should be in specific numberical range.
In addition, the composition and structure of dressing carrier have a certain impact to the antibiotic property of antiseptic dressing.
Embodiment 9 is also the control experiment of embodiment 3, and the two is the difference is that dressing carrier is formed by micro-nano fiber
The diameter of structure is different.Comparison it is found that antiseptic dressing provided by the invention antibacterial effect with micro-nano fiber structure diameter
Reduction and enhance.
Comparative example 1-4 is the comparative experiments of embodiment 3.As can be seen from the data in the table, anti-with identical solid content
In the case where microbial inoculum, the anti-microbial property of antiseptic dressing provided by the invention to be substantially better than use nano silver, soluble silver salt with
And anti-microbial property of the micron silver peroxide as the antiseptic dressing of antibacterial agent.Meanwhile antiseptic dressing provided by the invention is by receiving
Rice silver peroxide can increase the machine that nanometer silver peroxide is contacted with bacterium in conjunction with the dressing carrier with micro/nano fiber structure
Meeting, the relatively conventional antiseptic dressing (comparative example 4) using polyvinyl alcohol hydrogel as dressing carrier have better antibacterial effect.
Experimental example 2
For research dressing carrier provided by the invention, the shape appearance figure of nanometer silver peroxide and antiseptic dressing, it is with embodiment 3
Example, the dressing carrier provided embodiment 3, nanometer silver peroxide and antiseptic dressing carry out SEM electron-microscope scanning, it is specific such as Fig. 1 and
Shown in Fig. 3-5.
Wherein, Fig. 1 is the nanometer silver peroxide outside drawing that embodiment 3 provides, and Fig. 3 is the SEM Electronic Speculum of nanometer silver peroxide
Figure, You Tuzhong is it will be evident that nanometer silver peroxide provided by the invention structure in the form of sheets, and size is more uniform.And
Fig. 2 is the SEM electron microscope of the silver peroxide (comparative example 3) prepared using conventional method, and as can be seen from Figure, silver peroxide is in
Block structure, and size is unevenly distributed.
Fig. 4 is the SEM electron microscope for the dressing carrier that embodiment 3 provides, and Fig. 5 is the SEM for the antiseptic dressing that embodiment 3 provides
Electron microscope.It can be seen from the figure that nanometer silver peroxide can be supported on dressing carrier, and closely tied with dressing carrier
It closes, the problem of being split away off from dressing carrier there is no nanometer silver peroxide in use.
In addition, carrying out antibacterial by taking embodiment 3 and blank control group as an example for the anti-microbial property of further verifying antiseptic dressing
Measuring (antibacterial experiment measuring method is with experimental example 1).Wherein blank control group is to be not added with antibacterial during the experiment to apply
Material.
Antiseptic dressing provided by the invention has Escherichia coli and staphylococcus aureus it can be seen from Fig. 6
There is apparent anti-microbial property.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of antiseptic dressing characterized by comprising
Dressing carrier, the micro/nano fiber structure formed for water soluble polymer；With,
Nanometer silver peroxide is distributed in the dressing carrier inside and/or surface.
2. antiseptic dressing according to claim 1, which is characterized in that the nanometer silver peroxide is in the antiseptic dressing
Solid content be 0.05-12wt%, preferably 1-10wt%；
And/or the nanometer silver peroxide is laminated structure, it is preferable that the nanometer silver peroxide with a thickness of 1-20nm, it is long
Degree or width independently are 500nm-2 μm.
3. antiseptic dressing according to claim 1 or 2, which is characterized in that the water soluble polymer include polyvinyl alcohol,
It is any in polyvinylpyrrolidone, poly- methylcellulose, polyacrylic acid, polyethylene glycol oxide, polylactic acid, chitosan or gelatin
It is a kind of or at least two combination, preferably polyvinyl alcohol.
4. antiseptic dressing according to claim 1 or 2, which is characterized in that the micro nanometer fiber that the dressing carrier is formed
The diameter of structure is 100nm-1 μm, preferably 150-900nm.
5. the preparation method of antiseptic dressing described in claim 1-4 any one, which comprises the following steps:
The mixed solution that nanometer silver peroxide and water soluble polymer are formed is subjected to electrostatic spinning, obtains antiseptic dressing.
6. the preparation method of antiseptic dressing according to claim 5, which is characterized in that nanometer silver peroxide and high water solubility
Thickener soln is also added in the mixed solution that molecule is formed, the thickener of the thickener soln accounts for the thickener soln
Mass volume ratio be 0.5-2%, preferably 1-1.5%；
Preferably, the thickener includes sodium carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium alginate, gathers
In vinyl alcohol, polyacrylic acid or polyethylene glycol oxide any one or at least two combination.
7. the preparation method of antiseptic dressing according to claim 5, which is characterized in that the technological parameter packet of electrostatic spinning
It includes: spinning voltage 12-18kV；And/or mixed solution flow velocity is 0.5-1.5mL/min；And/or receiving distance is 5-
15cm。
8. according to the preparation method of antiseptic dressing described in claim 5-7 any one, which is characterized in that the nanometer peroxide
Change silver preparation method the following steps are included:
Persulfate, highly basic, surfactant and inorganic soluble silver salt are mixed and carried out precipitation reaction, reaction is obtained
Sediment separation, obtains a nanometer silver peroxide.
9. the preparation method of antiseptic dressing according to claim 8, which is characterized in that the persulfate includes persulfuric acid
Potassium and/or sodium peroxydisulfate；
And/or the inorganic soluble silver salt includes silver nitrate and/or silver acetate；
And/or the highly basic includes sodium hydroxide and/or potassium hydroxide；
And/or the surfactant is ionic surface active agent, it is preferable that the ionic surface active agent is alkyl sulfonic acid
Salt or alkyl sulfate, preferably lauryl sodium sulfate, myristyl sodium sulfonate, sodium cetanesulfonate or detergent alkylate
In sodium sulfonate any one or at least two combination.
10. antiseptic dressing described in claim 1-4 any one is applied using antibacterial described in claim 5-9 any one
Application of the antiseptic dressing made from the preparation method of material in biomedicine field.
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