CN109200332A - A kind of biodegradable hemostasis bone wax and preparation method thereof - Google Patents
A kind of biodegradable hemostasis bone wax and preparation method thereof Download PDFInfo
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- CN109200332A CN109200332A CN201811418783.XA CN201811418783A CN109200332A CN 109200332 A CN109200332 A CN 109200332A CN 201811418783 A CN201811418783 A CN 201811418783A CN 109200332 A CN109200332 A CN 109200332A
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- bone wax
- biodegradable
- hemostasis
- gelatin
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 57
- 230000023597 hemostasis Effects 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims abstract description 35
- 108010010803 Gelatin Proteins 0.000 claims abstract description 34
- 229920000159 gelatin Polymers 0.000 claims abstract description 34
- 239000008273 gelatin Substances 0.000 claims abstract description 34
- 235000019322 gelatine Nutrition 0.000 claims abstract description 34
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 34
- 229920001515 polyalkylene glycol Polymers 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims abstract description 19
- 230000000694 effects Effects 0.000 claims abstract description 14
- 239000007864 aqueous solution Substances 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 239000000243 solution Substances 0.000 claims abstract description 11
- 238000013019 agitation Methods 0.000 claims abstract description 8
- 238000006243 chemical reaction Methods 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 108010010779 glutamine-pyruvate aminotransferase Proteins 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 230000000025 haemostatic effect Effects 0.000 abstract description 6
- 238000007789 sealing Methods 0.000 abstract description 4
- 229940030225 antihemorrhagics Drugs 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000001993 wax Substances 0.000 description 42
- 239000000463 material Substances 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 238000004880 explosion Methods 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 235000013871 bee wax Nutrition 0.000 description 3
- 239000012166 beeswax Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- -1 ammonia Amide Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The present invention provides a kind of biodegradable hemostasis bone wax, prepared composition is made of C2-C3 polyalkylene glycol, glutamine transaminage and gelatin, preparation method is that C2-C3 polyalkylene glycol is first added in glutamine transaminage aqueous solution under magnetic agitation effect, add the aqueous gelatin solution sufficiently dissolved, it is reacted under water bath chader, then the middle reaction 5-10min under 80-100 DEG C of water bath condition, it is cooled to room temperature while stirring, hemostasis bone wax of the invention has degradability, excellent sealing characteristics and quick-acting haemostatic powder performance.
Description
Technical field
The present invention relates to hemostatic material technical fields, relate more specifically to a kind of hemostasis bone wax and its system that can give birth to solution degradation
Preparation Method.
Background technique
Bone wax is a kind of material that marrow portion capillary oozing of blood is blocked by physical method, can effectively block cancellous bone
Bleeding, the hemostasis that can be used for when various first-aid patients bone oozings of blood.The specific mechanism of action of bone wax is: one side bone wax is stopping blooding
There is very high absorption to liquid in the process, by absorbing the moisture in blood rapidly in the bleeding surface of a wound to promote blood platelet
Concentration, to enhance the agglutination speed and agglutinability of blood platelet；On the other hand, it is gluey that water-setting is formed after bone wax water suction, it can
It blocks in wound surface, increases the effect of hemostasis.In addition, can be formed to peripheral vessels has centainly after bone wax water swelling
The contention effect of pressure further promotes hemostasis.
Clinically present used bone wax, is mostly 70% beeswax and the mixture of 30% vaseline, has good
Softening performance, energy plastotype, nontoxic after rubbing softening with hand rubbing, but can not be degraded and absorb by body.Since beeswax and vaseline are mixed
The bone wax material for closing object preparation is unable to organism absorption, leaves the probability that will increase infection as foreign matter in vivo.Simultaneously as point
Sub- gap is too small, bone tissue can not by bone wax material, can hindering bone growth, it is postoperative will appear that wound do not recover for a long time ask
Topic, needs to carry out postoperative debridement when necessary.Treatment time is not only extended in this way, also increases the pain of patient.
Therefore it develops that a kind of haemostatic effect is good and the bone wax material of degradable absorption, while bone wax being made to can satisfy clinic
The mechanical property requirements used have great importance and are worth.
Summary of the invention
The purpose of the present invention is being absorbed for bone wax non-degradable in the prior art, leaves and be unfavorable for wound healing in vivo
The defects of, a kind of biodegradable hemostasis bone wax is provided.The present invention turns amine by C2-C3 polyalkylene glycol, glutamine
Not only there is excellent physics to block, clog performance for the effect of the coordinated of enzyme and gelatin three, the bone wax product being prepared
And haemostatic effect, and fully biodegradable absorbs, while product has excellent mechanical performance.
In order to solve the above technical problems, the technical scheme adopted by the invention is that:
A kind of biodegradable hemostasis bone wax, prepared composition is by C2-C3 polyalkylene glycol, glutamine transaminage
It is formed with gelatin, the mass ratio of the C2-C3 polyalkylene glycol, glutamine transaminage and gelatin are as follows: 1:2-4:8-10.
In mentioned component, C2-C3 polyalkylene glycol, glutamine transaminage and gelatin mutual cooperation can generate it is excellent
Different closure haemostatic effect, three are indispensable.
In above-mentioned mass ratio, if glutamine transaminage, less than 2, gelatin cannot be fully modified, if paddy ammonia
Amide transaminase is greater than 4, then the sealing characteristics of bone wax is poor.
It is unfavorable if gelatin is greater than 10 if gelatin less than 8, cannot generate good plugging effect in above-mentioned mass ratio
In the growth of newborn bony structures.
Effective plugging material when bone wax is for cancellous bone bleeding, traditional material are the mixture of paraffin and beeswax, body
Interior non-degradable, therefore will limit the growth of newborn bony structures.Hemostasis bone wax of the invention is logical to use C2-C3 polyalkylene
Glycol, glutamine transaminage and gelatin are made, and block with excellent physics, clog performance and haemostatic effect, and can be complete
Complete biodegradable absorbs, and without limitation on the growth of newborn bony structures, while product has excellent mechanical performance.
The present invention also provides a kind of preparation methods of biodegradable hemostasis bone wax comprising following steps:
S1. glutamine transaminage aqueous solution is prepared；
S2. C2-C3 polyalkylene glycol is first added in glutamine transaminage aqueous solution under magnetic agitation effect, then
The aqueous gelatin solution sufficiently dissolved is added, reacts 20-30min under 30-50 DEG C of water bath chader；
S3. the middle reaction 5-10min under 80-100 DEG C of water bath condition, is cooled to room temperature while stirring.
Compared with prior art, the beneficial effects of the present invention are:
The present invention provides a kind of biodegradable hemostasis bone wax and preparation method thereof, the prepared composition of the bone wax that stops blooding by
C2-C3 polyalkylene glycol, glutamine transaminage and gelatin composition have the function of that degradability and excellent physical block and fastly
Fast anthemorrhagic performance.The preparation method of hemostasis bone wax provided by the invention is water-soluble in glutamine transaminage under magnetic agitation effect
C2-C3 polyalkylene glycol is first added in liquid, adds the aqueous gelatin solution sufficiently dissolved, is reacted under water bath chader,
Then the middle reaction 5-10min under 80-100 DEG C of water bath condition, is cooled to room temperature while stirring.Hemostasis bone wax of the invention
Ingredient is simple, and preparation process is simple, and the hemostasis bone wax of preparation has suitable volume sweell(ing) rate and saturated water absorption, bone wax
Degradation time is 5-10 weeks, and burst pressure is not less than 120mmHg, has good plugging effect, can be widely applied to orthopaedics and stop
Blood field.
Specific embodiment
The present invention is further illustrated With reference to embodiment, but embodiment the present invention is not done it is any
The restriction of form.
Embodiment 1
A kind of biodegradable hemostasis bone wax, prepared composition is by C2-C3 polyalkylene glycol, glutamine transaminage
It is formed with gelatin, the mass ratio of the C2-C3 polyalkylene glycol, glutamine transaminage and gelatin are as follows: 1:2:8.It is described to stop
The preparation method of blood bone wax the following steps are included:
S1. glutamine transaminage aqueous solution is prepared；
S2. C2-C3 polyalkylene glycol is first added in glutamine transaminage aqueous solution under magnetic agitation effect, then
The aqueous gelatin solution sufficiently dissolved is added, reacts 30min under 30 DEG C of water bath chader；
S3. the middle reaction 10min under 80 DEG C of water bath conditions, is cooled to room temperature while stirring.
Embodiment 2
A kind of biodegradable hemostasis bone wax, prepared composition is by C2-C3 polyalkylene glycol, glutamine transaminage
It is formed with gelatin, the mass ratio of the C2-C3 polyalkylene glycol, glutamine transaminage and gelatin are as follows: 1:4:8.It is described to stop
The preparation method of blood bone wax the following steps are included:
S1. glutamine transaminage aqueous solution is prepared；
S2. C2-C3 polyalkylene glycol is first added in glutamine transaminage aqueous solution under magnetic agitation effect, then
The aqueous gelatin solution sufficiently dissolved is added, reacts 20min under 50 DEG C of water bath chader；
S3. the middle reaction 8min under 90 DEG C of water bath conditions, is cooled to room temperature while stirring.
Embodiment 3
A kind of biodegradable hemostasis bone wax, prepared composition is by C2-C3 polyalkylene glycol, glutamine transaminage
It is formed with gelatin, the mass ratio of the C2-C3 polyalkylene glycol, glutamine transaminage and gelatin are as follows: 1:2:10.It is described to stop
The preparation method of blood bone wax the following steps are included:
S1. glutamine transaminage aqueous solution is prepared；
S2. C2-C3 polyalkylene glycol is first added in glutamine transaminage aqueous solution under magnetic agitation effect, then
The aqueous gelatin solution sufficiently dissolved is added, reacts 30min under 30 DEG C of water bath chader；
S3. the middle reaction 5min under 100 DEG C of water bath conditions, is cooled to room temperature while stirring.
Embodiment 4
A kind of biodegradable hemostasis bone wax, prepared composition is by C2-C3 polyalkylene glycol, glutamine transaminage
It is formed with gelatin, the mass ratio of the C2-C3 polyalkylene glycol, glutamine transaminage and gelatin are as follows: 1:4:10.It is described to stop
The preparation method of blood bone wax the following steps are included:
S1. glutamine transaminage aqueous solution is prepared；
S2. C2-C3 polyalkylene glycol is first added in glutamine transaminage aqueous solution under magnetic agitation effect, then
The aqueous gelatin solution sufficiently dissolved is added, reacts 25min under 40 DEG C of water bath chader；
S3. the middle reaction 7min under 95 DEG C of water bath conditions, is cooled to room temperature while stirring.
Comparative example 1
A kind of biodegradable hemostasis bone wax, component are made of glutamine transaminage and gelatin, remaining is the same as implementation
Example 1.
Comparative example 2
A kind of biodegradable hemostasis bone wax, the matter of C2-C3 polyalkylene glycol, glutamine transaminage and gelatin
Measure ratio are as follows: 1:1:8, remaining is the same as embodiment 1.
Comparative example 3
A kind of biodegradable hemostasis bone wax, the matter of C2-C3 polyalkylene glycol, glutamine transaminage and gelatin
Measure ratio are as follows: 1:4:12, remaining is the same as embodiment 1.
Performance test
(1) resistance to compression explosion bulge test
External resistance to compression explosion bulge test experimental method: pressure test method is used, the thickness with multi-pore structure is specifically prepared
Degree is the acrylic plectane of 1cm, and plectane closed can be fixed on pressure tester port, and pressure tester is that there are plectane interfaces
Acrylic box, the opposite connection pressure-detecting device and device for exerting of plectane interface, after closed acrylic box connects plectane,
Hemostasis bone wax material of the invention is smeared in plectane aperture position, material will fill up entire hole, and plectane direction is downward, in box
Water is filled with, press and detects leakage numerical value.
External resistance to compression explosion bulge test, embodiment 1-4 are carried out to the hemostasis bone wax that embodiment 1-4 and comparative example 1-3 is obtained
The burst pressure of acquisition is not less than 120mmHg, and comparative example 1-3 is then lower than 120mmHg.
(2) cellulotoxic experiment
Culture cell is contacted by leaching liquor, using L929 as experimental cell, embodiment 1-4 is evaluated in cell proliferation observation
Toxic effect of the prepared bone wax to cell in vitro.The experimental results showed that hemostasis bone wax of the invention has good safety
Property, it has no toxic side effect to cell growth.
(3) validity experiment is blocked
By embodiment 1-4 resulting materials by external resistance to compression explosion bulge test experiments have shown that it blocks validity, specific experiment
Method is: preparing the acrylic plectane with a thickness of 1cm with multi-pore structure, plectane closed can be fixed on pressure tester end
Mouthful, pressure tester is that there are the acrylic box of plectane interface, the opposite connection pressure-detecting devices and pressure of plectane interface
Device smears this material in plectane aperture position after closed acrylic box connects plectane, and material will fill up entire hole, circle
Plate direction is downward, and water is filled in box, presses and detects leakage numerical value.The experimental results showed that the equal energy of embodiment 1-4 resulting materials
It is enough effectively blocked, the sealing characteristics of comparative example 2-3 is secondly, the sealing characteristics of comparative example 1 is worst.
(4) hemostasis validity experiment
After experimental dog is anaesthetized, using normal sterile surgical procedure, dog hind leg skin is cut, manufactures bone defect bleeding.It is real
It tests a group hemostasis bone wax of use embodiment 1-3 to stop blooding, as a result can effectively stop blooding in 15 seconds, and existing without oozing of blood
As haemostatic effect is significant.And comparative example 1 needs 40 seconds, comparative example 2 needs 30 seconds, and comparative example 3 needs 20 seconds.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (6)
1. a kind of biodegradable hemostasis bone wax, which is characterized in that its prepared composition includes C2-C3 polyalkylene glycol, paddy
Glutamine transaminase and gelatin.
2. the biodegradable hemostasis bone wax of one kind according to claim 1, which is characterized in that its prepared composition is by C2-
C3 polyalkylene glycol, glutamine transaminage and gelatin composition.
3. the biodegradable hemostasis bone wax of one kind according to claim 2, which is characterized in that the poly- alkylene of C2-C3
The mass ratio of base glycol, glutamine transaminage and gelatin are as follows: 1:2-4:8-10.
4. the preparation method of biodegradable hemostasis bone wax according to claim 1 to 3, which is characterized in that including as follows
Step:
S1. glutamine transaminage aqueous solution is prepared；
S2. C2-C3 polyalkylene glycol is first added in glutamine transaminage aqueous solution under magnetic agitation effect, adds
The aqueous gelatin solution sufficiently dissolved, reacts 20-30min under 30-50 DEG C of water bath chader；
S3. the middle reaction 5-10min under 80-100 DEG C of water bath condition, is cooled to room temperature while stirring.
5. the preparation method of biodegradable hemostasis bone wax according to claim 4, which is characterized in that further include step
S4 carries out irradiation sterilization to obtained hemostasis bone wax.
6. the preparation method of biodegradable hemostasis bone wax according to claim 4, which is characterized in that described sufficiently molten
The preparation method of the aqueous gelatin solution solved is crosslinking agent to be added in aqueous gelatin solution to carry out crosslinking Treatment, then be placed in water
Sufficiently it is swollen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811418783.XA CN109200332A (en) | 2018-11-26 | 2018-11-26 | A kind of biodegradable hemostasis bone wax and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811418783.XA CN109200332A (en) | 2018-11-26 | 2018-11-26 | A kind of biodegradable hemostasis bone wax and preparation method thereof |
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| CN109200332A true CN109200332A (en) | 2019-01-15 |
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| CN201811418783.XA Pending CN109200332A (en) | 2018-11-26 | 2018-11-26 | A kind of biodegradable hemostasis bone wax and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101816801A (en) * | 2003-01-09 | 2010-09-01 | 聚合物器官股份有限公司 | Biomedical foams |
| CN101854960A (en) * | 2006-12-15 | 2010-10-06 | 生命连结有限公司 | Gelatin-transglutaminase hemostatic dressings and sealants |
| US20120253298A1 (en) * | 2010-09-30 | 2012-10-04 | Ethicon Endo-Surgery, Inc. | Layered tissue thickness compensator |
| CN102719411A (en) * | 2012-06-18 | 2012-10-10 | 华东师范大学 | Microbial transglutaminase and application thereof |
| CN103816562A (en) * | 2013-12-02 | 2014-05-28 | 华东师范大学 | Rapid hemostatic product for war wounds and preparation method thereof |
| CN108187128A (en) * | 2018-02-07 | 2018-06-22 | 广州迈普再生医学科技有限公司 | A kind of absorbable hemostasis bone wax and preparation method thereof |
| CN108187129A (en) * | 2018-02-07 | 2018-06-22 | 广州迈普再生医学科技有限公司 | A kind of absorbable gelatin styptic powder and preparation method thereof |
-
2018
- 2018-11-26 CN CN201811418783.XA patent/CN109200332A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101816801A (en) * | 2003-01-09 | 2010-09-01 | 聚合物器官股份有限公司 | Biomedical foams |
| CN101854960A (en) * | 2006-12-15 | 2010-10-06 | 生命连结有限公司 | Gelatin-transglutaminase hemostatic dressings and sealants |
| US20120253298A1 (en) * | 2010-09-30 | 2012-10-04 | Ethicon Endo-Surgery, Inc. | Layered tissue thickness compensator |
| CN102719411A (en) * | 2012-06-18 | 2012-10-10 | 华东师范大学 | Microbial transglutaminase and application thereof |
| CN103816562A (en) * | 2013-12-02 | 2014-05-28 | 华东师范大学 | Rapid hemostatic product for war wounds and preparation method thereof |
| CN108187128A (en) * | 2018-02-07 | 2018-06-22 | 广州迈普再生医学科技有限公司 | A kind of absorbable hemostasis bone wax and preparation method thereof |
| CN108187129A (en) * | 2018-02-07 | 2018-06-22 | 广州迈普再生医学科技有限公司 | A kind of absorbable gelatin styptic powder and preparation method thereof |
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Application publication date: 20190115 |