CN109199689A - The cornea therapy device of absorption plant is instilled based on tunable optical component group and solution - Google Patents
The cornea therapy device of absorption plant is instilled based on tunable optical component group and solution Download PDFInfo
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- CN109199689A CN109199689A CN201810988183.0A CN201810988183A CN109199689A CN 109199689 A CN109199689 A CN 109199689A CN 201810988183 A CN201810988183 A CN 201810988183A CN 109199689 A CN109199689 A CN 109199689A
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- 210000004087 cornea Anatomy 0.000 title claims abstract description 62
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 26
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 19
- 238000011282 treatment Methods 0.000 claims abstract description 48
- 238000012545 processing Methods 0.000 claims abstract description 47
- 239000001301 oxygen Substances 0.000 claims abstract description 42
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 42
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000003504 photosensitizing agent Substances 0.000 claims abstract description 35
- 239000003814 drug Substances 0.000 claims abstract description 17
- 229940079593 drug Drugs 0.000 claims abstract description 17
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 16
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 14
- 230000000694 effects Effects 0.000 claims abstract description 12
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960002477 riboflavin Drugs 0.000 claims abstract description 8
- 235000019192 riboflavin Nutrition 0.000 claims abstract description 8
- 239000002151 riboflavin Substances 0.000 claims abstract description 8
- 241000282376 Panthera tigris Species 0.000 claims abstract description 6
- 210000001508 eye Anatomy 0.000 claims description 30
- 239000000243 solution Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
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- 239000007788 liquid Substances 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 2
- 208000026062 Tissue disease Diseases 0.000 abstract description 5
- 241000196324 Embryophyta Species 0.000 description 16
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/10—Eye inspection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
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- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
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- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
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- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
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Abstract
A kind of cornea therapy device instilling absorption plant based on tunable optical component group and solution, comprising: central processing unit；Light-source system in pairs is arranged in laser group, including ultraviolet laser and green (light) laser, the two parallel；Tunable optical component group according to set patterns by the light source of laser group makes to irradiate the desired effect for reaching cross-linking reaction on surface；Closed chamber, inside are equipped with the suction ring that art eye is fixed for adsorbing ocular tissue's surrounding skin；Oxygen feedway, for conveying oxygen into closed chamber；Solution instills absorption plant, and for importing the drug containing photosensitizer to art eye surface, photosensitizer is using riboflavin and the red component mixed in proportion of tiger；Observed result for being observed in real time cornea therapy situation, and is transmitted to central processing unit and handled by measuring system.The device can greatly improve the effect for the treatment of cornea tissue disease and the efficiency for the treatment of.
Description
The application be application No. is 201610895446.4, it is entitled " a kind of for treating the device of cornea tissue disease "
Patent application divisional application.
Technical field
The present invention relates to the Medical Devices for the treatment of eye disease, especially a kind of cornea therapy devices.
Background technique
Keratoconus is one kind with kerectasis, a kind of central thinning ophthalmology disease for protruding forward, being characterized in cone
Disease.Can be unilateral side can also be high disease stage with bilateral, usual puberty, can generally stop developing between 30 years old to 40 years old.
Its disease incidence is 0.05% or so.It can patient's be ametropia to causing, the damage of serious person's eyesight.From the nineties in last century,
By ultraviolet light emulsion such as riboflavin, tissue can be promoted to be crosslinked this technology and be applied to the treatment of keratoconus and worked as
In, it has been extremely improved the effect for treating this disease.
But traditional therapeutic equipments and treatment method, which is all unable to system, comprehensively refines this therapeutic process, is primarily present
Following problem:
1, excessively single for the control of laser, unconverted irradiation cannot reach the desired effect of crosslinking for a long time.
2, the light source selection of laser is excessively single, cannot introduce other visible lights and treat, to reduce in treatment to trouble
The injury of person and doctor.
3, corneal thickness can not be treated directly less than 400 μm, direct irradiation can damage ocular tissue.
4, in terms of for the importing of drug, in such a way that traditional syringe instills, absorption of drugs effect is not
Very well, lack to ambient enviroment oxygen concentration, the control such as temperature.
5, there cannot be the real-time observation method an of simple possible for cornea therapy situation.
6, the system and data established are not complete enough, lack to design for different patients over the course for the treatment of and implement personalization
Therapeutic scheme.
Summary of the invention
It is a primary object of the present invention to overcome the deficiencies of the prior art and provide a kind of cornea therapy device, greatly mention
The effect of height treatment and the efficiency for the treatment of.
To achieve the above object, the invention adopts the following technical scheme:
A kind of cornea therapy device, comprising:
Central processing unit；
Laser group, including ultraviolet laser and green (light) laser, the two are arranged light-source system in pairs parallel, when work
The central processing unit, which first controls, opens the green (light) laser, controls unlatching again when the mechanics parameter of measurement does not change
The ultraviolet laser continues to irradiate；
Tunable optical component group, for the light source of laser group being sent to art eye surface according to the light pattern of setting and can be by
The central processing unit control, is adjusted the irradiation of laser, so as to reach the desired effect of cross-linking reaction on irradiation surface；
Closed chamber, inside are equipped with the suction ring that art eye is fixed for adsorbing ocular tissue's surrounding skin；
Oxygen feedway is supplied oxygen for conveying oxygen into the closed chamber for cross-linking reaction；
Solution instills absorption plant, and for importing the drug containing photosensitizer to art eye surface, photosensitizer uses riboflavin
With the red component mixed in proportion of tiger, to generate cross-linking reaction in oxygen under ultraviolet light and green light irradiation；
Observed result for being observed in real time cornea therapy situation, and is transmitted to the centre by measuring system
Reason device is handled.
Further:
Make the indoor suction of the closing chamber for carrying out forvacuum processing to the closed chamber including vacuum plant
Ring adsorbs the skin around ocular tissue, while also promoting the indoor air discharge of the closing chamber to improve in the closed chamber
Oxygen shared by ratio.
The wavelength for the green light that the green (light) laser issues irradiates the energy density model on surface within the scope of 532 ± 10nm
It encloses for 0-0.50W/cm2, the diaphragm diameter for irradiating surface is 8-15mm at a distance from 1-1.5cm, with irradiation surface；It is described ultraviolet
For the ultraviolet wavelength that light laser issues within the scope of 365 ± 10nm, the energy density range for irradiating surface is 0-100mW/
cm2, irradiation surface diaphragm diameter is in 7-13mm, with irradiation surface distance 8-15mm, it is preferable that the ultraviolet laser fortune
The row time reaches the predetermined time and automatically powers off, and when more preferable 10min automatically powers off.
Ultraviolet laser is corresponded in the tunable optical component group and green (light) laser respectively includes that driver can be passed through
The first optical element, the second optical element, laser amplitude device, the first beam-splitter, the second beam-splitter, reflecting plate, third adjusted
Beam-splitter, first optical element, second optical element, the reflecting plate, the third beam-splitter, the laser tune
Width device can be translated and be rotated in optical path by driver control；The light that the ultraviolet laser comes out is by the first optics member
Part, second optical element, to form the aperture that energy density and diameter are suitble to；By the first optics member
Part, second optical element light a part reflected by first beam-splitter, another part pass through first beam-splitter
Afterwards, the reflecting mirror is partially reflected by second beam-splitter, passes through the third beam-splitter again through reflecting mirror reflection
Reflection finally meets at main optical path with the light by first beam-splitter reflection, and two-way light is overlapped mutually, when the phase of two-way light
Strip interference fringe is formed on irradiation surface when the integral multiple of some fixed numbers of phase difference, by adjusting first light splitting
The movement and rotation of plate, second beam-splitter, the reflecting plate, the third beam-splitter, are formed by strip interference fringe
It can be mobile in irradiation area；The laser amplitude device makes the energy density for irradiating surface exist for regulating and controlling the energy on irradiation surface
It treats in required range.
The tunable optical component group further includes being placed in where first optical element and second optical element
Optical path on Darman raster element, with irradiation surface formed laser dot-matrix pattern, or using irradiation surface generate ring
The optical diffraction device of shape pattern.
The measuring system includes pressure sensor and oxygen atom detector, and the pressure sensor and the oxygen atom are visited
Device is surveyed to be used to send the numerical value of the indoor pressure value of the closing chamber and concentration of oxygen atoms to central processing unit, the centre
Reason device adjusts the oxygen output of the oxygen feedway by control solenoid valve.
The solution instills absorption plant and includes electro-ionic osmosis device, photosensitizer injection device, infrared heater and surpass
Sound drug introducing apparatus；The electro-ionic osmosis device includes the netted or spiral helicine electro-ionic osmosis electrode for being attached to eyeball surface
Piece；The photosensitizer injection device includes by the atomizer on liquid ultrasonic atomized spray to cornea, it is preferable that described photosensitive
The heating rod or resistance wire for heating photosensitizer are set in agent injection device, more preferably control temperature at 35 DEG C -40 DEG C；
The ultrasonic medicinal introducing apparatus applies ultrasonic wave effect to photosensitizer to increase absorption of the eyes to photosensitizer；The infrared ray adds
Hot device irradiates cornea over the course for the treatment of, to form the temperature field of anterior corneal surface.
The measuring system includes optical measurer, ultrasonic meter, charge coupled cell, temperature sensor；It is described
The light that optical measurer detection is returned from irradiation surface reflection, so that central processing unit calculates dress according to detection optical signal prosessing
Set the distance and angle and corneal thickness of anterior corneal surface, it is preferable that the optical measurer is furnished with independent illumination unit
Independently to measure the thickness of cornea；The ultrasonic meter issues ultrasonic wave to irradiation surface, receives the ultrasound of return
Signal is simultaneously transmitted to the central processing unit, to calculate the variation of the parameters such as anterior corneal surface regionality elasticity modulus；The electricity
Optical signal and processing in lotus coupling element light path are converted into electric signal and are transmitted to the central processing unit, to calculate light
According to intensity；The temperature sensor detects anterior corneal surface temperature and is transmitted to central processing unit.
The measuring system includes visual pursuit measuring instrument, and the visual pursuit measuring instrument observes non-art eye, to non-art eye
Surface carries out the capture of corneal center, and the central processing unit is according to the adjusting of the observed case of the visual pursuit measuring instrument
Tunable optical component group is to control treatment optical path for the irradiating angle and distance of art eye.
It further include the film that thickens with biocompatibility for being attached to anterior corneal surface, the film that thickens is the preferred sheep of natural membranes
Film or the preferred electrostatic spinning biofilm of artificial bio-membrane's film, drug, light, oxygen can thicken needed for film arrival through described
Surface to be treated.
The inner surface for thickening film lays the microsensor of light transmission, for measure include ocular surface pressure,
One of photosensitizer concentration, oxygen concentration, cornea mechanical property or many kinds of parameters, and it is transmitted to central processing unit, it is preferable that institute
It states and thickens the inner surface of film and be also equipped with micro radio circuit, central processing unit is transferred data to by wireless transmission.
The beneficial effects of the present invention are as follows:
In the embodiment of the present invention, ultraviolet light and green light irradiation are penetrated into the anterior corneal surface of photosensitizer by laser group, produced
Biochemical cross-linking reaction, to enhance the mechanical property of cornea.The present invention is improved the radiation modality of light source and light, will be single
One replacing light source is ultraviolet light and green light, preferably adopts the radiation modality for gathering around the dot matrix of raster pattern.Using oxygen as protection gas, with
Enhance the concentration of the oxygen of chemical crosslinking.And using the method for chemical spray and ultrasonic delivery drug.Not for corneal thickness
Microsensor is preferably attached to preferably by film is thickened to assist in the treatment of and thickens film by the situation in direct therapeutic domain
On to measure the variations of the parameters such as cornea mechanical property.The embodiment of the present invention cornea can be carried out it is accurate, personalized, can
The treatment of adjustment.The device of embodiment can greatly improve the effect for the treatment of cornea tissue disease and the efficiency for the treatment of.
The advantages of specific embodiment of the invention, is embodied in:
1. using double light-source systems, green light (such as 532nm wavelength) is combined with ultraviolet light (such as 365nm wavelength) to be crosslinked,
Wherein green light is small to the damage of eyes, can suitably reduce the irradiation time of ultraviolet light, to reduce ultraviolet light to patient and doctor
Injury.
2. introducing dot matrix laser, the variable illuminating method of figure laser, grating can according to need the position tune of irradiation
The shape of whole laser optimizes cross-linking reaction.
3. having used oxygen as protection gas and providing vacuum plant auxiliary adjustment concentration.
4. using ultrasonic delivery drug, the infiltration capacity of drug is improved.
5. using the irradiation of infrared ray to the heating for the treatment of surface in therapeutic process, while with electrically heated rod or resistance wire pair
The drug for needing to inject is heated, and the progress for the treatment of is accelerated.
6. the patient for cornea patient especially thickness less than 400 μm uses a kind of good biology of biocompatibility
Film is fitted in eyeball surface adjuvant treatment, and has microsensor that can transfer data in server inside it and carry out directly
The data transmission connect.
7. the photosensitizer for the treatment of is using riboflavin and the red drug mixed in proportion of tiger, solution can be in lower progress of not sharing the same light
Cross-linking reaction.
8. being heated using infrared ray to treatment surface, the temperature field on control treatment surface.
9. the comparative analysis strategy of big data can be used, analogy, simulation are carried out to the patient data treated by this method
Corresponding treatment strategy out is treated, and over the course for the treatment of, constantly generates correlation data, right in the range of safety allows
The dosage for the treatment of is adjusted.And database can be constantly updated, the details that patient treats in archives will be transmitted to total clothes
It is analyzed in business device, keeps the information of successive treatment more comprehensive.
The embodiment of the present invention, which compares the prior art, has following clear superiority:
1. increasing green light can be enhanced therapeutic effect, and can be corresponding in such a way that double light-source systems combine
The irradiation time of ultraviolet light is reduced, reduces and patient and doctor is injured, reduces Operative risk.
2. the variable radiation modality of dot matrix laser, figure laser, grating can effectively comply with the mechanical periodicity of crosslinking, make
Time that each reactant concentration reacts is chemically reacted by chance in the best time.
3. oxygen can be adjusted as the amount of reactant by the way that purity oxygen is added, while use a small-sized pumping
Vacuum is to closed chamber progress forvacuum processing, on the skin for being adsorbed on the suction ring of closed chamber around ocular tissue, together
When the indoor air of chamber can be discharged, improve ratio shared by chamber indoor oxygen, oxygen forms work under the irradiation of ultraviolet light
Property oxygen atom, accelerates the progress of chemical crosslink reaction.
4. ultrasonic wave promotes drug to penetrate into cornea, it is rapidly achieved affected part.
5. a pair affected part is heated with mid-infrared light, this laser is comparatively safe to eyes, and therapentic part can be improved
Temperature accelerates the reaction for the treatment of to carry out.
6. the patient for cornea patient especially corneal thickness less than 400 μm is good using a kind of biocompatibility
Biomembrane be fitted in eyeball surface, the effective injury for controlling ultraviolet light to the other tissues of eye.Biomembrane can be naturally
Amnion, be also possible to the artificial electrostatic spinning biofilm of tailored thicknesses.The sensor on its surface can pass many kinds of parameters
It is sent to central processing unit, forms direct data transmission.
7. the indoor pressure of closing chamber can be adjusted by the supply amount of solenoid valve control oxygen, when needing to measure one
When the mechanics parameter of a little corneas, the indoor pressure of chamber can change, by obtaining ultrasonic wave to the feedback signal of ocular tissue, meter
Calculate the parameters such as the elasticity modulus of cornea.
Temperature Field Control is carried out to treatment surface 8. using infrared ray, accelerates the progress of cross-linking reaction.
9. the related data of the initial data before patient's treatment, real-time measuring data and hospital in therapeutic process is one
The database of continuous renewal, the data such as the thickness of cornea, the mechanical property of cornea, ultraviolet irradiation amount, riboflavin usage amount
The Active treatment algorithm an of various dimensions is constituted, to automatically adjust dosage and intensity of illumination according to treatment stage, this can
Being completed under the control of doctor, provide it is a kind of based on the therapeutic scheme of real data for doctor select.This safety
Control can be established according to the clinical case of big data and improve medical data base, obtained with safest data multiplied by related coefficient
The most reasonable approach for the treatment of.
Detailed description of the invention
Fig. 1 is the system diagram that the embodiment of the present invention fits cornea therapy device.
Fig. 2 is the variation structure for the crosslinking apparatus illumination system that the embodiment of the present invention is suitable for personalized treatment cornea tissue
Figure.
Fig. 3 is the variation structure chart that the embodiment of the present invention calibrates irradiation system.
Fig. 4 is the variation structure chart of cornea of embodiment of the present invention heating device.
Fig. 5 is the schematic diagram of the double light source laser therapies of the embodiment of the present invention.
Fig. 6 is the schematic diagram that laser irradiation of the embodiment of the present invention forms grating.
Fig. 7 is the schematic diagram that laser of the embodiment of the present invention forms dot matrix.
Fig. 8 is the schematic diagram of ultrasonic wave of embodiment of the present invention drugs with function.
Fig. 9 is the schematic diagram that the embodiment of the present invention passes through voltage difference electro-ionic osmosis.
Figure 10 is the schematic diagram that the embodiment of the present invention passes through ultrasonic measurement cornea mechanical property under gas pressure.
Figure 11 is that cornea of the embodiment of the present invention thickens schematic diagram of the film in conjunction with microsensor.
Figure 12 is the flow chart of Individualized computer of embodiment of the present invention treatment.
Description of symbols:
0- eyes (art eye), 0 '-non-art eye, 1- central processing unit, 2- closed chamber, 3- optical measurer, 4- operation are flat
Platform, 5- ultraviolet laser, 6- vacuum plant, 7- ultrasonic meter, 8- electro-ionic osmosis device, 9- oxygen storage tank, 10- electricity
Lotus coupling element, the first optical element of 11-, the second optical element of 12-, 13- laser amplitude device, the first beam-splitter of 14-, 15-
Two beam-splitters, 16- reflecting plate, 17- third beam-splitter, 18- temperature sensor, 19- pressure sensor, 20- oxygen atom detector,
21- photosensitizer injection device, 22- normal saline flushing device, 23- Darman raster element, 24- driver, 25- visual pursuit are surveyed
Amount instrument, 26- infrared heater, 27- electro-ionic osmosis electrode slice, 28- thicken film, 29- microsensor, 30- green (light) laser,
31- ultrasound imports medicinal therapy instrument, 41- irradiation light, 42- strip interference fringe, 43- laser dot-matrix pattern, 44- ultrasonic signal, 45-
Oxygen.
Specific embodiment
It elaborates below to embodiments of the present invention.It is emphasized that following the description is only exemplary,
The range and its application being not intended to be limiting of the invention.
It is in one embodiment, a kind of for treating the device of the cornea tissue disease of eyes 0 refering to fig. 1 to Figure 10, it fits
For personalized treatment cornea tissue disease, the device mainly includes: laser group, tunable optical component group, central processing unit
1, closed chamber 2, oxygen feedway, solution instill absorption plant, measuring system, vacuum plant 6 etc..The device can pass through spy
Fixed closed-loop control system measures the real-time parameter of cornea, to be directed to different phase, cornea of different nature, imposes different
Photosensitizer doses, illumination type, intensity of illumination etc. are crosslinked purpose to reach expected.
Laser group preferably includes ultraviolet laser 5 and green (light) laser 30, can be adjusted by driver 24 adjustable
Ultraviolet laser is corresponded in optical element group and green (light) laser respectively includes the first optical element 11, the second optical element
12, laser amplitude device 13, the first beam-splitter 14, the second beam-splitter 15, reflecting plate 16, third beam-splitter 17, oxygen feedway
Including oxygen storage tank 9, it includes electro-ionic osmosis device 8, photosensitizer injection device 21, physiological saline punching that solution, which instills absorption plant,
Cleaning device 22, infrared heater 26 thicken film 28, ultrasonic medicinal introducing apparatus 31, and measuring system includes optical measurer 3, surpasses
Acoustic measurement instrument 7, charge coupled cell 10, temperature sensor 18, pressure sensor 19, oxygen atom detector 20, visual pursuit
Measuring instrument 25, microsensor 29.Vacuum plant 6, closed chamber 2.In one embodiment, ultraviolet laser and green light swash
The optical path of light device shares a laser amplitude device.
The ultraviolet wavelength that ultraviolet laser 5 issues irradiates the energy density range on surface within the scope of 365 ± 10nm
For 0-100mW/cm2, irradiation surface diaphragm diameter is in 7-13mm, with irradiation surface distance 8-15mm.It possesses independent current source,
Inside possesses independent counter, and runing time is automatically powered off more than 10min.
The wavelength for the green light that green (light) laser 30 issues irradiates the energy density range on surface within the scope of 532 ± 10nm
For 0-0.50W/cm2, the diaphragm diameter for irradiating surface is 8-15mm at a distance from 1-1.5cm, with irradiation surface.It possesses independence
Power supply.
In tunable optical component group, the first optical element 11, the second optical element 12 can be in optical paths by driver 24
Control moves freely, and the first beam-splitter 14, the second beam-splitter 15, third beam-splitter 17 and reflecting plate 16 are controlled simultaneously by driver 24
And can planar rotate, laser amplitude device 13 can be moved in optical path and can be revolved in the plane perpendicular to optical path
Turn.
Preferably, one is placed in the horizontal optical path of the first optical element 11 and the second optical element 12 horizontal to move
Dynamic Darman raster element 23 is a kind of optical diffraction device, can predetermined region be formed required for dot pattern with
And various patterns of different shapes.
Central processing unit 1 can carry out all data transmissions with operating platform 4, it can be achieved that closed-loop control.
Operating platform 4 possesses a complete operation interface, can be saved with real-time observed data and the book of final entry, in
Central processor 1 carries out mandatory control to each component, and possesses independent power supply.
Oxygen feedway is supplied oxygen by oxygen storage tank 9, and by oxygen atom detector 20 to the feedback of oxygen concentration, in
Central processor 1 can control the amount of oxygen and pressure in closed chamber 2 by the opening and closing of control solenoid valve.
The electro-ionic osmosis device 8 that solution instills in absorption plant includes electro-ionic osmosis electrode slice 27, and electro-ionic osmosis device 8 is gathered around
There is independent DC power supply, current control is led in 0.5-2.5mA, the cathode of electro-ionic osmosis electrode slice 27 using cricoid light-permeable
Electric material is attached to ocular surface or thickens 28 surface of film.
The film 28 that thickens that solution instills in absorption plant is a kind of good biofilm of biocompatibility, is attached to cornea
Surface avoids cornea by the excessive radiation in ultraviolet light.According to clinical different needs, the film of different-thickness, day are chosen
The preferred amnion of right film, the preferred electrostatic spinning biofilm of artificial bio-membrane's film of tailored thicknesses.Drug and light can be penetrated smoothly
Amnion or artificial bio-membrane's film reach required surface to be treated, and gas permeability, translucency are good, oxygen by it and it is extraneous into
Row exchange.
The multiple sensors such as the mountable lambda sensor of film inner surface, sensitizer concentration sensor, pressure sensor are being thickened,
The material requirements of these sensors is light-permeable, there is independent micro power and circuit.
Solution instills the photosensitizer injection device 21 of absorption plant, its drug use the principle that is atomized liquid ultrasonic into
Row spray, inside can install an electrically heated rod and temperature sensor additional, convenient for the absorption of photosensitizer, temperature can be controlled
At 35 DEG C -40 DEG C.Selected photosensitizer can generate cross-linking reaction with oxygen under the irradiation of ultraviolet light or green light, be
One kind transportable solion under the action of voltage.The preferred riboflavin solution of the photosensitizer of ultraviolet light, green light it is photosensitive
The preferred tiger of agent is red, both solution can also be mixed in proportion.
It can also include a kind of variation that solution, which instills device, be exactly to smear surface in drug, install an infrared heating additional
Device 26, infrared wave-length coverage (not damaged to ocular tissue), i.e., 1.5-3.0 μm in, spot diameter 5-15mm.
Solution instills the ultrasonic medicinal introducing apparatus 31 in device, its strength range is 0-1.5W/cm2, the frequency of ultrasonic wave
Rate is 10-30kHz.
Measuring system includes an optical measurer 3, measures the distance between anterior corneal surface and equipment and angle, and will count
According to being transported in central processing unit 1.
Measuring system may include an independent visual pursuit measuring instrument 25, it is the non-art eye 0 ' of observation, this equipment will
Related with treated eyes (art eye) 0 other equipment generate linkage, to control need to treat optical path irradiating angle and away from
From.
Ultrasonic meter 7 issues ultrasonic wave to irradiation surface, receives ultrasonic signal and is transmitted to central processing unit 1, with
Calculate the variation of the parameters such as anterior corneal surface regionality elasticity modulus.
Charge coupled cell 10 is converted into electric signal by processing to optical signal and is transmitted to central processing unit.
18 surface temperature of temperature sensor is detected and is transmitted to central processing unit 1.
Pressure sensor 19 detects the pressure value in closed chamber 2 and is transmitted to central processing unit 1.
Microsensor 29 in measuring system is fitted in the inner surface that auxiliary thickens film, can be taken with many places a little, surface
The material of circlewise light-permeable can be designed, and microcircuit can be installed, centre is transferred data to by electromagnetic wave
Manage device 1.
There are a suction ring in closed chamber 2 and eyes junction, form negative pressure in chamber when vacuum plant 6 works,
It is firmly adsorbed on the skin of ocular surface.
The working principle and the course of work of embodiment set forth further below.
As shown in Figure 1, the light come out through ultraviolet laser 5 passes through the first optical element 11, the second optical element 12, it can be with
Using two parallel moveable lens groups, user issues signal to central processing unit 1 by operating platform and automatically adjusts,
It is also possible to mechanical hand adjustment, principle is identical as the flexible principle of camera lens, it is therefore an objective to form energy density and diameter is big
Small suitable aperture.As shown in figure 5, including also a green (light) laser 30, it is arranged in parallel with ultraviolet laser 5 and optical path, work
Green (light) laser 30 is first opened when making, and ultraviolet laser 5 is then turned on when the mechanics parameter of measurement does not change and continues to shine
It penetrates.The mixed solution that photosensitizer selects riboflavin red with tiger is configured.
As shown in Figure 1, by the first optical element 11, the second optical element 12 light via beam-splitter 14, a part warp
It crosses beam-splitter 15 and reaches charge coupled cell 10, be converted into electric signal by processing and be transmitted to central processing unit 1, pass through specific journey
Sequence calculates the intensity of illumination.
Reflecting mirror 16 is reflected into, by beam-splitter 17 by light a part of beam-splitter 15, main optical path is eventually passed back to, with warp
The light for crossing the reflection of beam-splitter 14 converges.Beam-splitter 14, beam-splitter 15, beam-splitter 17, reflecting mirror 16 can rotate freely, wherein
Beam-splitter 17, reflecting mirror 16 can be mobile in vertical direction, and all processes are controlled by central processing unit 1.The light of main optical path
Irradiation light 41 is converged into after being overlapped mutually with light through reflection, when the integral multiple of the phase phase difference of two-way light some fixed numbers,
Strip interference fringe 42 can be formed on irradiation surface.By adjusting beam-splitter 14, beam-splitter 15, beam-splitter 17, reflecting mirror 16
Movement and rotation, being formed by strip interference fringe can be mobile in irradiation area.
As shown in Fig. 2, a Darman raster element 23 is placed in where the first optical element 11, the second optical element 12
Optical path on, in this way irradiation surface just form laser dot-matrix pattern 43 as shown in FIG. 6, can also use other patterns light
Learn diffractive optical element, such as annular.This pattern forms periodic fluctuation on treatment surface.
As shown in Figure 1, laser amplitude device 13 can be mobile in vertical direction and be rotated, it can by adjusting laser amplitude device 13
With control irradiation surface energy, this process also by central processing unit 1 control, it is therefore an objective to allow irradiation surface energy density
Reach in the required range for the treatment of.
As shown in Figure 1, optical measurer 3 receives the light returned from irradiation surface reflection, pass through the signal of central processing unit
Processing calculates equipment to the distance of anterior corneal surface, can also calculate corneal thickness.Optical measurer 3 can install one additional solely
Vertical illumination unit, such as independent laser range finder can independently measure the thickness of cornea, without others at any time
Light source is supported.
As shown in figure 3, the capture of corneal center can be carried out to non-art eye surface by visual pursuit measuring instrument 25, then
The position that beam-splitter 14, beam-splitter 15, beam-splitter 17 and reflecting mirror 16 are adjusted by central processing unit 1, allows laser irradiation to exist
Treatment region.What visual pursuit measuring instrument 25 was in alignment with is non-art eye because the characteristics of motion of human eye be it is the same, pass through fixation
Equipment place and calibrate for error, the movement for allowing equipment to follow non-art eye can voluntarily adjust optical path, allow optical path according to wanting
Ask the surface for being radiated at art eye.
As shown in Figure 1, pressure sensor 19 and oxygen atom detector 20 by closed chamber 2 pressure value and oxygen atom it is dense
The numerical value of degree sends central processing unit 1 to, and central processing unit 1 adjusts oxygen by simulating the amount of oxygen control solenoid valve of needs
The oxygen output of gas storage tank 9.
As shown in Figure 1, vacuum plant 6 starts with to be responsible for forming the air discharge in closed chamber 2 negative in equipment
Pressure, such closed chamber 2 can be fixed on the skin around eyes by inhaling ring, after oxygen 45 is passed through, guarantee internal oxygen
Gas concentration can be improved.Vacuum plant 6 guarantees that initial pressure is negative value in closed chamber, when hypertonia in closed chamber 2 or
Person reduces the concentration of medium of heat transfer, can according to circumstances work at any time.Closed chamber 2 can also install one additional visually in side
The case where transparent window, doctor can observe the inside by the window.Complete equipment can pass through elastic band or similar cap
The device of shape is fixed on the head of people.
By adjusting pressure in closed chamber 2, elastic deformation can occur for cornea.Ultrasonic meter 7 is sent out to irradiation surface
It ultrasonic wave and is received out, received ultrasonic signal 44 can also change, in receiving ultrasonic signal and being transmitted to
Central processor 1 calculates the variation of the parameters such as anterior corneal surface regionality elasticity modulus, and cornea table can also be simulated by software
The case where face, the mechanical property comparison of different location on the cornea contours figure that operating platform 4 can observe simulation.
As shown in figure 11, thickening film 28 is that the patient according to particular patients ' such as corneal thickness less than 400 μm wears, and is selected
Natural biological film or the relatively good artificial bio-membrane's film of biocompatibility, natural biological film such as amnion, tailored thicknesses it is artificial
The preferred electrostatic spinning biofilm of biofilm.Microsensor 29, this sensing can be placed in the inner surface for thickening film 28
Device has good translucency, can place minicell, and the pressure of the ocular surface of measurement is transmitted to central processing unit 1.?
Different sensor measurement other parameters, such as the photosensitizer concentration on surface, oxygen concentration etc. can be installed.
Atomizer is installed on photosensitizer injection device 21 as shown in Figure 1, is injected in the center of cornea,
There is the heating rod or resistance wire that can be heated to photosensitizer in inside, heats before photosensitizer needs to inject to it.Lead to again
It crosses ultrasonic medicinal introducing apparatus 31 and ultrasonic wave effect is carried out to photosensitizer, increase absorption of the eyes to photosensitizer.As Fig. 4 can
The additional infrared heater 26 in the irradiation surface of cornea, this illuminator are directed at cornea over the course for the treatment of and are irradiated,
The temperature field gone into anterior corneal surface, 18 surface temperature of temperature sensor are fed back.
As shown in Fig. 1 and Fig. 9, the electro-ionic osmosis device 8 with independent DC power supply is installed additional in anterior corneal surface, it can be with
Design reticulates or spiral helicine electro-ionic osmosis electrode slice is attached to eyeball surface, and material has the property of light transmission.It can be with
Electro-ionic osmosis device 8 is installed to the inner surface for thickening film, it is integrated with microsensor.
Illumination and the drug for the treatment of can be adjusted according to measurement parameter using suitable software based on this set therapeutic equipment
Supply amount personalized therapeutic scheme is simulated according to the analysis of big data, accurate treatment is implemented to affected part.This is one
The control system of closed loop, measurement parameter include corneal tension, temperature, oxygen concentration etc., and the parameter of input includes age, gender, disease
History, corneal thickness, corneal topography etc..Related data and the process for the treatment of can be stored in electronic databank, form one completely
Electronic record, convenient for postoperative tracking.And analyze the process for the treatment of comprehensively according to big data, it is formed and constantly tends to be rationally perfect
Information bank is treated, is provided for the treatment of subsequent other patients based on clinical comparison information.
As shown in the process in Figure 12, the basic parameter of acquisition includes the age of patient, gender, medical history, corneal thickness, angle
The essential informations such as film topographic map.Data control group includes data of some basic parameters with reference to value, computer can according to
Past therapeutic process, therapeutic effect carry out analysis mode to treatment, and the parameter of real-time measurement includes the bullet of the temperature of cornea, cornea
The data such as property modulus, concentration of oxygen atoms.These real-time measured parameters can be compareed according to the safety value that a database generates,
If equipment can stop without in zone of reasonableness, doctor can be according to circumstances adjusted.Such as in the reasonable scope, these parameters
It can be carried out with the computer simulation desired amount generated to illumination group for being treated to cornea, the treatment intermittent phase will continue to survey
Amount, reaches effect, and treatment can stop, if not up to effect can also return to be compareed with safety value, repeatedly, until
Treatment stops.
The information that patient treats in archives can upload to other servers being connected with network, and server is by directly obtaining
It obtains relevant data to be analyzed and processed, improves existing database, more accurate guidance is provided therapeutic process.This is a set of
Method for updating system based on big data can gradually systematization, the treatment of other ophthalmology diseases can also be served data to.
The above content is combine it is specific/further detailed description of the invention for preferred embodiment, cannot recognize
Fixed specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs,
Without departing from the inventive concept of the premise, some replacements or modifications can also be made to the embodiment that these have been described,
And these substitutions or variant all shall be regarded as belonging to protection scope of the present invention.
Claims (10)
1. a kind of cornea therapy device for instilling absorption plant based on tunable optical component group and solution characterized by comprising
Central processing unit；
Laser group, including ultraviolet laser and green (light) laser, the two are arranged light-source system in pairs parallel, when work described in
Central processing unit, which first controls, opens the green (light) laser, is controlled described in unlatching again when the mechanics parameter of measurement does not change
Ultraviolet laser continues to irradiate；
Tunable optical component group, for the light source of laser group being sent to art eye surface according to the light pattern of setting and can be by described
Central processing unit control, is adjusted the irradiation of laser, so as to reach the desired effect of cross-linking reaction on irradiation surface；
Closed chamber, inside are equipped with the suction ring that art eye is fixed for adsorbing ocular tissue's surrounding skin；
Oxygen feedway is supplied oxygen for conveying oxygen into the closed chamber for cross-linking reaction；
Solution instills absorption plant, and for importing the drug containing photosensitizer to art eye surface, photosensitizer is using riboflavin and tiger
The red component mixed in proportion, to generate cross-linking reaction in oxygen under ultraviolet light and green light irradiation；The solution, which instills, to be inhaled
Receiving apparatus includes electro-ionic osmosis device, photosensitizer injection device, infrared heater and ultrasonic medicinal introducing apparatus；The ion is led
Entering device includes the netted or spiral helicine electro-ionic osmosis electrode slice for being attached to eyeball surface；The photosensitizer injection device packet
It includes the atomizer on liquid ultrasonic atomized spray to cornea；The ultrasonic medicinal introducing apparatus applies ultrasonic wave to photosensitizer and makees
To increase absorption of the eyes to photosensitizer；The infrared heater irradiates cornea over the course for the treatment of, to form cornea table
The temperature field in face；
Observed result for being observed in real time cornea therapy situation, and is transmitted to the central processing unit by measuring system
It is handled；
Vacuum plant makes the indoor suction ring absorption eye of the closing chamber for carrying out forvacuum processing to the closed chamber
Skin around organizing, while also promoting the indoor air discharge of the closing chamber to improve the indoor oxygen institute of the closing chamber
The ratio accounted for.
2. cornea therapy device as described in claim 1, which is characterized in that the wavelength for the green light that the green (light) laser issues
Within the scope of 532 ± 10nm, the energy density range for irradiating surface is 0-0.50W/cm2, the diaphragm diameter on surface is irradiated in 1-
It is 8-15mm at a distance from 1.5cm, with irradiation surface；The ultraviolet wavelength that the ultraviolet laser issues is in 365 ± 10nm model
In enclosing, the energy density range for irradiating surface is 0-100mW/cm2, irradiation surface diaphragm diameter is in 7-13mm, with irradiation surface
Distance 8-15mm.
3. cornea therapy device as claimed in claim 2, which is characterized in that the ultraviolet laser runing time reaches pre-
It fixes time and automatically powers off.
4. cornea therapy device as claimed in claim 3, which is characterized in that the ultraviolet laser runing time reaches
It is automatically powered off when 10min.
5. cornea therapy device as described in claim 1, which is characterized in that correspond to ultraviolet light in the tunable optical component group
Laser and green (light) laser respectively include the first optical element, the second optical element, laser tune that can be adjusted by driver
Width device, the first beam-splitter, the second beam-splitter, reflecting plate, third beam-splitter, first optical element, second optics member
Part, the reflecting plate, the third beam-splitter, the laser amplitude device can be translated and be rotated in optical path by driver control；
The light that the ultraviolet laser comes out passes through first optical element, second optical element, to form energy density
And the aperture that diameter is suitable；By first optical element, second optical element light a part by described
The reflection of one beam-splitter, another part are partially reflected into the reflection by second beam-splitter after first beam-splitter
Mirror is reflected by the third beam-splitter again through reflecting mirror reflection, the light finally reflected with process first beam-splitter
Main optical path is met at, two-way light is overlapped mutually, when the integral multiple of the phase phase difference of two-way light some fixed numbers in irradiation table
Face forms strip interference fringe, by adjusting first beam-splitter, second beam-splitter, the reflecting plate, the third
The movement and rotation of beam-splitter, being formed by strip interference fringe can be mobile in irradiation area；The laser amplitude device is used for
The energy on regulation irradiation surface makes the energy density for irradiating surface in the required range for the treatment of.
6. cornea therapy device as claimed in claim 5, which is characterized in that
The tunable optical component group further includes the light being placed in where first optical element and second optical element
The Darman raster element of road to form laser dot-matrix pattern on irradiation surface, or generates circular chart using on irradiation surface
The optical diffraction device of case.
7. cornea therapy device as described in claim 1, which is characterized in that set in the photosensitizer injection device for heating
The heating rod or resistance wire of photosensitizer.
8. cornea therapy device as claimed in claim 7, which is characterized in that heating rod in the photosensitizer injection device or
Person's resistance wire controls temperature at 35 DEG C -40 DEG C.
9. cornea therapy device as claimed in any one of claims 1 to 8, which is characterized in that the measuring system includes optics
Measuring appliance, ultrasonic meter, charge coupled cell, temperature sensor；The optical measurer is detected from irradiation surface reflection
Light back, so as to central processing unit according to detection optical signal prosessing calculate device to the distance and angle of anterior corneal surface and
Corneal thickness；The ultrasonic meter issues ultrasonic wave to irradiation surface, receives the ultrasonic signal of return and is transmitted to described
Central processing unit, to calculate the variation of the parameters such as anterior corneal surface regionality elasticity modulus；The charge coupled cell detection light
The optical signal of road and processing is converted into electric signal and is transmitted to the central processing unit, to calculate the intensity of illumination；The temperature
Degree sensor detection anterior corneal surface temperature is simultaneously transmitted to central processing unit.
10. cornea therapy device as described in any one of claim 1 to 9, which is characterized in that the optical measurer is equipped with only
Vertical illumination unit is independently to measure the thickness of cornea.
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| CN201610895446.4A CN106264855B (en) | 2016-10-13 | 2016-10-13 | A kind of device for treating cornea tissue disease |
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| CN201810988183.0A Expired - Fee Related CN109199689B (en) | 2016-10-13 | 2016-10-13 | Cornea treatment device based on adjustable optical element group and solution dripping absorption device |
| CN201810988212.3A Expired - Fee Related CN108992243B (en) | 2016-10-13 | 2016-10-13 | Cornea treatment device based on improved solution dripping absorption device |
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| CN102387764A (en) * | 2009-04-01 | 2012-03-21 | 威孚莱有限公司 | Device for the laser radiation treatment of an eye |
| CN102824246A (en) * | 2011-06-15 | 2012-12-19 | 史文勇 | Intelligent laser emulsification cataract system using laser |
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| CN113034608A (en) * | 2021-03-11 | 2021-06-25 | 东北大学秦皇岛分校 | Corneal surface morphology measuring device and method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109248022A (en) | 2019-01-22 |
| CN109248022B (en) | 2020-06-02 |
| CN108992243B (en) | 2020-05-22 |
| CN108992243A (en) | 2018-12-14 |
| CN106264855A (en) | 2017-01-04 |
| CN109199689B (en) | 2020-05-22 |
| CN106264855B (en) | 2018-11-06 |
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