CN107303218A - The security control of angle/sclera crosslinking technological and efficiency optimization system - Google Patents
The security control of angle/sclera crosslinking technological and efficiency optimization system Download PDFInfo
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- CN107303218A CN107303218A CN201710295645.6A CN201710295645A CN107303218A CN 107303218 A CN107303218 A CN 107303218A CN 201710295645 A CN201710295645 A CN 201710295645A CN 107303218 A CN107303218 A CN 107303218A
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00865—Sclera
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- A—HUMAN NECESSITIES
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00872—Cornea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00885—Methods or devices for eye surgery using laser for treating a particular disease
- A61F2009/00893—Keratoconus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0645—Applicators worn by the patient
- A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
- A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
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Abstract
The invention provides a kind of security control of angle/sclera crosslinking technological and efficiency optimization system, including secure threshold control system, efficiency optimization system；Secure threshold control system carries out refrigeration regulation and control according to real-time, non-contacting tissue temperature measured value；Efficiency optimization system carries out humidity according to real-time humidity and/or oxygen concentration measurements and/or oxygen concentration regulates and controls.The present invention prevents treatment excessive in the case where ensureing reinforcing photochemical crosslinking reaction.Meanwhile, a kind of efficiency optimization method and automation control system are provided based on photochemical mechanism reinforcing reaction principle, by controlling the oxygen concentration and humidity for the treatment of space to strengthen photochemical reaction cross-link intensity, strengthens therapeutic effect.Therefore the present invention is can to strengthen corneal cross-linking effect while reducing the system of reaction side effect, is characterized in by controlling environmental oxygen concentration and humidity to strengthen cross-linking effect, while carrying out local organization cooling by the refrigerating plant of temperature monitoring automatic start humidifying.
Description
Technical field
The present invention relates to cornea and/or the safe handling control of sclera crosslinking technological and efficiency optimization, in particular it relates to
The security control of angle/sclera crosslinking technological and efficiency optimization system and method, more particularly, to based on photothermal injury and based on light
The automation control system and method for chemical mechanism reinforcing reaction principle, the system and method are particularly suitable for use in various based on photochemical
Learn the cornea of principle and/or the clinic and laboratory applications of sclera crosslinking technological.Angle/sclera refers to cornea and/or sclera.
Background technology
Photochemical crosslinking is that one kind produces photochemical reaction by photoactive substance under excitation source effect, causes collagen egg
The method that white molecule forms covalent cross-linking to connect between collagenous fibres, this method can be played in cornea or scleral tissue
Strengthen tissue rigidity, kill the effects, treatment keratoconus, quasi-molecule such as pathogenic microorganism in tissue, resistance microbial enzyme digestion
The disease such as corneal ectasia and ocular infection after refractive surgery.This photo chemistry technology also known as angle for strengthening corneal tension
Film crosslinking technological.
Mainly there are two kinds of mechanism in light-tissue reaction：A photothermies (Photothermal reaction), under light exposure,
It makes the tie point of tissue rapidly absorb energy, and temperature can be raised significantly, be denatured collagen tissue, caused fibrosis and scar
Change.B photochemical effects (Photochemical reaction), under light exposure, it causes photosensitive molecular to be changed into triplet state, enters
And ambient oxygen effect under produce radical ion, this process can kill pathogenic microorganism in tissue, collagenous fibres it
Between form covalent cross-linking and complete tissue adhesion (photochemical crosslinking process), this photochemical effect do not cause rise and the egg of temperature
The denaturation of white matter.
Cornea and/or sclera crosslinking technological are in diseases such as keratoconus, refractive surgery joint reinforcement, myopia, ocular infection
Treatment in mainly rely on photochemical effect.If during enhancing corneal cross-linking, photochemical reaction excessively causes part
Temperature rise, which is developed into, can then cause the muddy even scar of cornea tissue of otherwise transparent based on photochemical and thermal reaction, may result in
The natural translucency of eyeball, which lowers, there is complication, and more than normal body temperature, 10 DEG C can then cause comea fibrousization to cause scar
Influence corneal transparence is formed to affect one's power of vision.But require to need diagonal membrane tissue progress photochemical effect strong according to treatment
The regulation of degree, at present due to lacking safety control system and method, therefore, its practical application limited significantly.
Because photochemically induced tissue crosslinked action is the process of a different conditions oxygen conversion, therefore the oxygen in environment is dense
Degree can play a part of strengthening cross-linking effect.Experiment discovery gives high concentration oxygen environment and carries out photochemical therapy, can promote
The rush crosslinked action of sensitising agent+excite photoinduction, further enhances tissue rigidity.It is (attached according to the experimental data that we do not deliver
Fig. 1), compared with control group (Control groups), (O under high concentration oxygen environment2Group) cross-linking efficiency (cornea rigidity) can be improved
2.5 times and there is notable significant difference, and (Air groups) can strengthen 1.97 times of cornea rigidity and have system under normal air environment
Meter learns (N under difference, low-oxygen environment2Group) photochemical therapy do not have it is any enhancing cornea rigidity effect (without statistics it is poor
It is different).Crosslinking Curing circumstance conventional at present is air ambient (Air groups), and the present invention help to realize hyper-oxygen therapy environment with
Improve therapeutic effect or shorten treatment time.
The content of the invention
For defect of the prior art, it is an object of the invention to provide a kind of security control of angle/sclera crosslinking technological
And efficiency optimization system and method.
A kind of security control of angle/sclera crosslinking technological provided according to the present invention and efficiency optimization system, including safety
Threshold control system, efficiency optimization system；
Secure threshold control system carries out refrigeration regulation and control according to real-time, non-contacting tissue temperature measured value；
Efficiency optimization system carries out humidity according to real-time humidity and/or oxygen concentration measurements and/or oxygen concentration regulates and controls.
Preferably, secure threshold control system includes temperature-sensing system, refrigeration system, audio alert system, power supply control
System processed；
Pair that temperature-sensing system is contrasted according to tissue temperature measured value and default one or more temperature thresholds
Than result, control refrigeration system, audio alert system or power control system are started or closed.
Preferably, the temperature-sensing system is specially：
If tissue temperature measured value ＜ temperature thresholds 1, temperature-sensing system control refrigeration system, audio alert system,
Power control system is closed；
If temperature threshold 1≤tissue temperature measured value ＜ temperature thresholds 2, temperature-sensing system control refrigeration system, sound
Frequency warning system, power control system are closed；
If temperature threshold 2≤tissue temperature measured value ＜ temperature thresholds 3, temperature-sensing system starts refrigeration system and sound
Frequency warning system, closes power control system；
If temperature threshold 3≤tissue temperature measured value, temperature-sensing system starts refrigeration system and audio alert system,
And startup power supply control system is to cut off the power supply of light source light guide input system.
Preferably, temperature-sensing system includes temperature sensor, and temperature sensor launches light as signal using far infrared,
Measurement temperature under contact measured hoc scenario, does not obtain tissue temperature measured value；
Refrigeration system includes air blower and/or compression refrigerating machine, and with air blower, compression refrigerating machine enters alone or in combination
Row refrigeration.
Preferably, efficiency optimization system includes humidity input regulating system, oxygen concentration input regulating system, humidity detection system
System, oxygen concentration detection system；
Humidity inputs measurement humidity and the progress pair of default humidity value that regulating system is collected according to humidity detection system
Than, and humidity input regulation and control are carried out according to comparison result；
Oxygen concentration inputs the measurement oxygen concentration and default oxygen concentration that regulating system is collected according to oxygen concentration detection system
Contrasted, and humidity input carried out according to comparing result.
Preferably, humidity input regulating system is specially：
If measuring humidity ＜ presets humidity value, humidity input regulating system is regulated and controled to increase humidity to humidifier；
If measuring humidity >=default humidity value, humidity input regulating system closes humidifier to stop increasing humidity.
Preferably, oxygen concentration input regulating system is specially：
If measuring oxygen concentration ＜ presets oxygen concentration value, oxygen concentration input regulating system regulates and controls to oxygen input system
To improve oxygen concentration；
If measuring oxygen concentration >=default oxygen concentration value, oxygen concentration input regulating system regulates and controls to oxygen input system
To stop improving oxygen concentration.
Preferably, the scope of temperature threshold 1：37±1℃；The scope of temperature threshold 2：42±2℃；The model of temperature threshold 3
Enclose：47±2℃.
Preferably, the scope of humidity value is preset：20%~100%；The scope of default oxygen concentration：20%~100%.
Preferably, in addition to transparent confinement cover；
Transparent confinement cover provides transparent confinement treatment space；
Secure threshold control system collection tissue temperature measured value in transparent confinement treatment space carries out refrigeration regulation and control；
Efficiency optimization system collection humidity measurements and/or oxygen concentration measurements in transparent confinement treatment space, go forward side by side
Row humidity and/or oxygen concentration regulation and control.
Compared with prior art, the present invention has following beneficial effect：
The present invention provides a kind of temperature control device based on photothermal injury's principle and the temperature of area for treatment is monitored and controlled
System, guard system or power-off system are started by the setting of safety threshold temperature, are ensureing that reinforcing photochemical crosslinking is anti-
Prevent treatment excessive in the case of answering.Meanwhile, based on photochemical mechanism reinforcing reaction principle provide a kind of efficiency optimization method and
Automation control system, by controlling the oxygen concentration and humidity for the treatment of space to strengthen photochemical reaction cross-link intensity, enhancing treatment
Effect.Therefore the present invention is can to strengthen corneal cross-linking reaction efficiency, while reducing the system of its side effect, is characterized in passing through
Control treatment space oxygen concentration and humidity optimization therapeutic efficacy, local group is carried out by the refrigerating plant of temperature monitoring automatic start
Knit environment temperature control.
Brief description of the drawings
By reading the detailed description made with reference to the following drawings to non-limiting example, further feature of the invention,
Objects and advantages will become more apparent upon：
Fig. 1 is the test data schematic diagram of cross-linking efficiency (corneal tension) under the varying environments such as high concentration oxygen.
Fig. 2 is the structure and control principle schematic diagram of secure threshold control system.
Fig. 3 is the structure and control principle schematic diagram of efficiency optimization system.
In Fig. 1 " * * " represent compared with control group (Control), oxygen environment group (O2) tissue rigidity enhancing have significantly
Significant difference (p ＜ 0.01), " * " is represented with control group (Control) compared with, and normal oxygen environment/air group (Air) tissue is firm
Degree enhancing has significant difference (p ＜ 0.05).
Power control system in Fig. 2, is the power supply that external light source input system module is cut off when temperature is too high.
Embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples will be helpful to the technology of this area
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that to the ordinary skill of this area
For personnel, without departing from the inventive concept of the premise, some changes and improvements can also be made.These belong to the present invention
Protection domain.
The present invention provides the secure threshold control of cornea and/or sclera crosslinking technological based on photo-thermal and photochemical reaction principle
The control method of system and the control system processed, with overcome existing cornea and/or sclera be crosslinked instrument can not intelligently, safely,
The defect of abundant effective utilization.
The security control of the angle that the present invention is provided/sclera crosslinking technological and efficiency optimization system, including secure threshold control
System and efficiency optimization system.Secure threshold control system and efficiency optimization system specifically include temperature-sensing system, refrigeration system
System, humidity input regulating system, oxygen concentration input regulating system, audio alarm system and power control system, secure threshold
These subsystems of control system and efficiency optimization system are associated.
The present invention carries out refrigeration system by secure threshold control system according to real-time, non-contacting tissue temperature monitor value
Automatic intelligent regulation and control so that the temperature parameter of test serum is all the time in constant scope.Secure threshold is controlled
System mainly includes temperature-sensing system and refrigeration system.Temperature-sensing system sets dual-temperature threshold value, the first heavy temperature threshold
For alert threshold, associated audio warning system, the second weight temperature threshold is rotection thresholds, and the power supply of association power control system is opened
Close loop apparatus.
The present invention is automated by efficiency optimization system according to the relative humidity and oxygen concentration in real-time closing space
Intelligent control so that oxygen concentration and relative humidity are all the time in the range of one presets in closing space.Efficiency optimization
System mainly includes humidity and inputs regulating system and oxygen concentration input regulating system, in addition to real-time display system and concentration setting
System.Photothermal injury and photochemical reaction principle, corneal and/or sclera crosslinking are utilized based on this secure threshold control system
Reaction carries out actual time safety and controlled and intelligent automatic protection setting, prevents because the excessively caused cornea tissue of photochemical reaction is damaged
The purpose of wound.
As shown in Fig. 2 temperature-sensing system monitors ocular tissue temperature in real time, tissue temperature measured value is obtained (referred to as warm
Spend measured value), by being associated with refrigeration system and power control system, refrigeration system is carried out according to default different temperatures threshold value
Automation reaction type regulation or power control system closing.Temperature-sensing system starts different system according to measured temperature
(refrigeration system, audio alert system, power control system), wherein, the ＜ temperature thresholds 3 of 1 ＜ temperature thresholds of temperature threshold 2.Tool
Body algorithm is as follows：
(1) measured temperature ＜ temperature thresholds 1, do not start any system
(2) 1≤measured temperature of temperature threshold ＜ temperature thresholds 2, close refrigeration system
(3) 2≤measured temperature of temperature threshold ＜ temperature thresholds 3, start refrigeration system and audio alert system
(4) 3≤measured temperature of temperature threshold, control power control system is stopped power supply, and is cut off the electricity supply
Temperature-sensing system includes temperature sensor, and temperature sensor is launched light as signal using far infrared, do not contacted
Measurement temperature in the case of test serum, obtains measured temperature；
Refrigeration system includes air blower, and with air blower, compression refrigerating machine is freezed alone or in combination；
Temperature threshold 1, temperature threshold 2, these three temperature thresholds of temperature threshold 3 are adjustable, wherein：
- temperature threshold 1：Preferred value：37 DEG C, optional scope：37±1℃
- temperature threshold 2：Preferred value：40 DEG C, optional scope：42±2℃
- temperature threshold 3：Preferred value：45 DEG C, optional scope：47±2℃
If higher than 1 DEG C of 2 upper limit of temperature threshold (45 DEG C), endothelial cell and/or angle in therapeutic process may be caused
Film limbal stem cell fire damage, causes in treatment corneal endothelial damage following cell decompensation and/or re-epithelilization obstacle, infringement cornea
Skin physiological function is likely to occur the change of cornea mist sample, or even irreversibility opacity of the cornea influence visual function.If higher than temperature threshold 3
1 DEG C of the upper limit (50 DEG C), it is likely that instant photothermal injury occur, cause ocular tissue ischemia anoxic, cornea base in therapeutic process
The denaturation of matter collagen, lose transparency, may directly occur intraoperative compliaction, induce postoperative ocular tissue inflammation reaction, it is new
, there is irreversible corneal degeneration and/or new vessels, cause eyesight to decline immediately in angiogenic, infection tendency etc..
Visited as shown in figure 3, efficiency optimization system includes humidity input regulating system, oxygen concentration input regulating system, humidity
Examining system, oxygen concentration detection system.Humidity detection system, oxygen concentration detection system, temperature-sensing system connection transparent confinement are controlled
Space is treated, transparent confinement treatment space is also connected with light source light guide input system (crosslinking machine treatment light source light-guiding system).Wherein
Humidity detection system is associated with humidity input regulating system, and oxygen concentration detection system is associated with oxygen concentration input regulating system.Tool
Body algorithm is as follows：
(1) in transparent confinement treatment space：Measure humidity ＜ and preset humidity value, start humidity input regulating system, to increase
Plus the humidity in transparent confinement treatment space；Humidity >=default humidity value is measured, humidity input regulating system is closed, stops increase
Humidity in transparent confinement treatment space.
(2) in transparent confinement treatment space：Measure oxygen concentration ＜ and preset oxygen concentration value, start oxygen concentration input regulation system
System, to increase the oxygen concentration in transparent confinement treatment space；Oxygen concentration >=default oxygen concentration value is measured, oxygen concentration input is closed and adjusts
Section system, to stop increasing the oxygen concentration in transparent confinement treatment space.
Humidity detection system includes hygrosensor and humidification system, and hygrosensor is with lithium chloride or aluminum oxide hygrometer
For critical piece, humidification system is using supersonic atomizing humidifier as critical piece, and humidification system leads to humidity input regulating system
Oversampling circuit plate is attached, and intelligent switch is carried out as threshold value according to default humidity.
Oxygen concentration detection system includes oxygen probe and oxygen input system, and oxygen input system is using oxygenerator as main portion
Part, oxygenerator realizes that oxygen probe passes through circuit with oxygen concentration input regulating system by molecular sieve physical absorption and desorption technique
Plate is attached, and intelligent switch is carried out as threshold value according to default oxygen concentration value.
Default humidity value and default oxygen concentration preset value can adjust, wherein：
- preset humidity value (relative humidity)：Preferred value：85%, optional scope：20%~100%
- preset oxygen concentration：Preferred value：60%, optional scope：20%~100%, optionally, preset the optional model of oxygen concentration Enclosing can be 30%~100%
The presence that normal ocular is twinkled due to physiological, can keep the stabilization of ocular tear film (film layer of one layer of liquid) to deposit
Playing a part of moistening and protecting cornea tissue, maintain its physiological structure normal condition.But during photochemical crosslinking,
Need ocular exposure under light illumination, ocular environment is easily dried, if ocular microenvironment humidity is too low (being less than 20%), simultaneously
There is no the presence that physiological is twinkled, dry environment can cause corneal epithelium infringement, keratitis tendency, can be induced when serious postoperative
Xerophthalmia, corneal infection, therefore it is more important to ensure that the ocular microenvironment in therapeutic process is in an environment moistened.
Oxygen in tissue surrounding environment take part in the process of photochemical crosslinking, the participation without environment oxygen molecule, photosensitive point
Son can not be changed into the material of triplet state under laser action, follow-up photochemical crosslinking effect can not also be produced, if be less than
Normal air oxygen concentration (21%), then can not ensure the stability of therapeutic effect, therefore stable micro-loop is maintained in therapeutic process
Border oxygen concentration state is for ensureing that the effect (enhancing tissue rigidity) for being crosslinked treatment is particularly important.
The research that we do not deliver observes the effect that photochemical crosslinking is acted under different oxygen concentrations environment, as a result shows
(accompanying drawing 1)：Compared with control group (Control groups), (O2 groups) can improve cross-linking efficiency (cornea is firm under high concentration oxygen environment
Degree) 2.5 times and there is notable significant difference, and under normal air environment (Air groups) can strengthen 1.97 times of cornea rigidity and
There is under significant difference, low-oxygen environment (N2 groups) photochemical therapy there is no the effect of any enhancing cornea rigidity (without statistics
Difference).Cross-linking effect can be greatly enhanced by the oxygen concentration in exogenous control tissue surrounding microenvironment.
The specific embodiment of the present invention is described above.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, those skilled in the art can make a variety of changes or change within the scope of the claims, this not shadow
Ring the substantive content of the present invention.In the case where not conflicting, feature in embodiments herein and embodiment can any phase
Mutually combination.
Claims (10)
1. security control and the efficiency optimization system of a kind of angle/sclera crosslinking technological, it is characterised in that including secure threshold control
System, efficiency optimization system；
Secure threshold control system carries out refrigeration regulation and control according to real-time, non-contacting tissue temperature measured value；
Efficiency optimization system carries out humidity according to real-time humidity and/or oxygen concentration measurements and/or oxygen concentration regulates and controls.
2. security control and the efficiency optimization system of angle according to claim 1/sclera crosslinking technological, it is characterised in that
Secure threshold control system includes temperature-sensing system, refrigeration system, audio alert system, power control system；
The contrast knot that temperature-sensing system is contrasted according to tissue temperature measured value and default one or more temperature thresholds
Really, control refrigeration system, audio alert system or power control system are started or closed.
3. security control and the efficiency optimization system of angle according to claim 2/sclera crosslinking technological, it is characterised in that
The temperature-sensing system is specially：
If tissue temperature measured value ＜ temperature thresholds 1, temperature-sensing system control refrigeration system, audio alert system, power supply
Control system is closed；
If temperature threshold 1≤tissue temperature measured value ＜ temperature thresholds 2, temperature-sensing system control refrigeration system, audio police
Reporting system, power control system are closed；
If temperature threshold 2≤tissue temperature measured value ＜ temperature thresholds 3, temperature-sensing system starts refrigeration system and audio police
Reporting system, closes power control system；
If temperature threshold 3≤tissue temperature measured value, temperature-sensing system starts refrigeration system and audio alert system, and opens
Power control system is moved to cut off the power supply of light source light guide input system.
4. security control and the efficiency optimization system of angle according to claim 2/sclera crosslinking technological, it is characterised in that
Temperature-sensing system includes temperature sensor, and temperature sensor launches light as signal using far infrared, in not contact measured tissue
In the case of measurement temperature, obtain tissue temperature measured value；
Refrigeration system includes air blower and/or compression refrigerating machine, with air blower compression refrigerating machine system alone or in combination
It is cold.
5. security control and the efficiency optimization system of angle according to claim 1/sclera crosslinking technological, it is characterised in that
Efficiency optimization system includes humidity input regulating system, oxygen concentration input regulating system, humidity detection system, oxygen concentration detection system
System；
The measurement humidity that humidity input regulating system is collected according to humidity detection system is contrasted with default humidity value, and
Humidity input regulation and control are carried out according to comparison result；
Oxygen concentration inputs measurement oxygen concentration and the progress of default oxygen concentration that regulating system is collected according to oxygen concentration detection system
Contrast, and humidity input regulation and control are carried out according to comparing result.
6. security control and the efficiency optimization system of angle according to claim 5/sclera crosslinking technological, it is characterised in that
Humidity inputs regulating system：
If measuring humidity ＜ presets humidity value, humidity input regulating system is regulated and controled to increase humidity to humidifier；
If measuring humidity >=default humidity value, humidity input regulating system closes humidifier to stop increasing humidity.
7. security control and the efficiency optimization system of angle according to claim 5/sclera crosslinking technological, it is characterised in that
Oxygen concentration inputs regulating system：
If measuring oxygen concentration ＜ presets oxygen concentration value, oxygen concentration input regulating system is regulated and controled to carry to oxygen input system
High oxygen concentration；
If measuring oxygen concentration >=default oxygen concentration value, oxygen concentration input regulating system is regulated and controled to stop to oxygen input system
Only improve oxygen concentration.
8. security control and the efficiency optimization system of angle according to claim 3/sclera crosslinking technological, it is characterised in that
The scope of temperature threshold 1：37±1℃；The scope of temperature threshold 2：42±2℃；The scope of temperature threshold 3：47±2℃.
9. security control and the efficiency optimization system of angle according to claim 5/sclera crosslinking technological, it is characterised in that
The scope of default humidity value：20%~100%；The scope of default oxygen concentration：20%~100%.
10. security control and the efficiency optimization system of angle according to claim 1/sclera crosslinking technological, it is characterised in that
Also include transparent confinement cover；
Transparent confinement cover provides transparent confinement treatment space；
Secure threshold control system collection tissue temperature measured value in transparent confinement treatment space carries out refrigeration regulation and control；
Efficiency optimization system collection humidity measurements and/or oxygen concentration measurements in transparent confinement treatment space, and carry out wet
Degree and/or oxygen concentration regulation and control.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710295645.6A CN107303218A (en) | 2017-04-28 | 2017-04-28 | The security control of angle/sclera crosslinking technological and efficiency optimization system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710295645.6A CN107303218A (en) | 2017-04-28 | 2017-04-28 | The security control of angle/sclera crosslinking technological and efficiency optimization system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107303218A true CN107303218A (en) | 2017-10-31 |
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Application publication date: 20171031 |