CN109199448A - Pulsed-Wave Doppler imaging method and device based on HPRF - Google Patents
Pulsed-Wave Doppler imaging method and device based on HPRF Download PDFInfo
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- CN109199448A CN109199448A CN201811023371.6A CN201811023371A CN109199448A CN 109199448 A CN109199448 A CN 109199448A CN 201811023371 A CN201811023371 A CN 201811023371A CN 109199448 A CN109199448 A CN 109199448A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/488—Diagnostic techniques involving Doppler signals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/58—Testing, adjusting or calibrating the diagnostic device
Abstract
The present invention relates to a kind of Pulsed-Wave Doppler imaging method and device based on HPRF, the Pulsed-Wave Doppler imaging method based on HPRF includes: to calculate multiple emission parameters according to the position of destination sample frame, and each emission parameter includes different launch times and tranmitting frequency；Multiple emission parameters are traversed, and emit ultrasonic wave to the virtual sample boxes of destination sample frame and at least one according to the launch time traversed in the emission parameter and tranmitting frequency, carry out echo wave signal acquisition；Signal processing is carried out to collected echo-signal, obtains signal to be imaged；Traversal is completed to multiple emission parameters, signal progress frequency spectrum processing imaging to be imaged, an emission parameter is corresponded to per the signal to be imaged described all the way described in multichannel.Solve the problems, such as that Doppler shift information measured by the Pulsed-Wave Doppler imaging method based on HPRF in the prior art is not accurate enough using the Pulsed-Wave Doppler imaging method provided by the present invention based on HPRF and device.
Description
Technical field
The present invention relates to Doppler mapping technology field more particularly to a kind of Pulsed-Wave Doppler imaging sides based on HPRF
Method and device.
Background technique
In compuscan, Doppler mapping technology is widely used in the measurement of human bloodstream.Specifically, pulse
Wave doppler imaging (Pulsed Wave Spectral Doppler Imaging) method repeats to send out by Fixed Time Interval
Ultrasonic wave is penetrated to human body target tissue, and acquires the echo-signal reflected via this human body destination organization, and then according to this echo
The Doppler shift information that this human body destination organization of signal measurement is generated by blood flow, to reflect the blood of human body target tissue
The dynamic variation of liquid stream.Wherein, the Fixed Time Interval of repeat its transmission ultrasonic wave is defined as pulse-recurrence time interval (Pulse
Repeat Interval, PRI), which determine the peak veloity,PV models that can recognize that by Doppler shift information
It encloses.
It should be appreciated that in some cases, for example human body target tissue is certain big arteries, blood flow velocity compared with
Height needs higher pulse recurrence frequency (Pulse Repeat Frequency, PRF), i.e., pulse-recurrence time interval fall
Number, but since such arteries is deeper in the intracorporal position of people, the two-way time of ultrasonic wave is longer, when pulse being caused to repeat
Between be spaced larger, and cannot achieve higher pulse recurrence frequency.
It is proposed to this end that a kind of Pulsed-Wave Doppler imaging method for being based on HPRF (High PRF), can reflect people
People's intracorporal blood flow variation when body targeted tissue site is deeper.Specifically, emitted using higher pulse recurrence frequency super
Sound wave can collect multiple echo-signals simultaneously, be equivalent to and reflect via different depth position in human body, this different depth position
The position being woven in human body including human body target group is set, how general thus can be completed for the echo-signal that the position is reflected
Strangle imaging.
However, collected echo-signal is substantially to be directed to multiple and different depth locations during echo wave signal acquisition
The stack result for reflecting obtained echo-signal, due to higher pulse recurrence frequency, the echo letter of different depth position reflection
Number centre frequency it is very close, human body target group be woven in the position (position of destination sample frame) in human body reflection echo letter
Number will by remaining position (positions of virtual sample boxes) reflect echo-signal interference, and cause measurement Doppler frequency
It is not accurate enough to move information, and then influences HPRF imaging performance.
Summary of the invention
In order to solve the above-mentioned technical problem, it is an object of the present invention to provide how general a kind of impulse wave based on HPRF is
Strangle imaging method and device.
Wherein, the technical scheme adopted by the invention is as follows:
In a first aspect, a kind of Pulsed-Wave Doppler imaging method based on HPRF, comprising: according to the position of destination sample frame
Multiple emission parameters are calculated, each emission parameter includes different launch times and tranmitting frequency；Traverse multiple transmitting ginsengs
Number, and according to the launch time traversed in the emission parameter and tranmitting frequency transmitting ultrasonic wave to destination sample frame and at least
One virtual sample boxes carry out echo wave signal acquisition；Signal processing is carried out to collected echo-signal, obtains signal to be imaged；
Complete traversal to multiple emission parameters, the signal to be imaged described in multichannel carries out frequency spectrum processing imaging, per all the way it is described to
Imaging signal corresponds to an emission parameter.
Second aspect, a kind of Pulsed-Wave Doppler imaging device based on HPRF, comprising: parameter calculating module is used for root
Multiple emission parameters are calculated according to the position of destination sample frame, each emission parameter includes different launch times and tranmitting frequency；
Ultrasonic wave transmitting module, for traversing multiple emission parameters, and according to the launch time traversed in the emission parameter
Emit ultrasonic wave to the virtual sample boxes of destination sample frame and at least one with tranmitting frequency, carries out echo wave signal acquisition；Signal processing
Module obtains signal to be imaged for carrying out signal processing to collected echo-signal；Spectral imaging module, for more
A emission parameter completes traversal, the signal progress frequency spectrum processing imaging to be imaged described in multichannel, per described to be imaged all the way
Signal corresponds to an emission parameter.
In one exemplary embodiment, described device further include: parameter adjustment module, if being used for the first demodulated signal institute
Aliasing occurs on frequency domain for frequency spectrum corresponding to corresponding spectrum and at least one second demodulated signal, then in multiple emission parameters
Tranmitting frequency be adjusted；Wherein, first demodulated signal is the echo-signal demodulation by destination sample frame reflection
It generates, at least 1 second demodulated signal is generated by the echo-signal demodulation of at least one virtual sample boxes reflection.
In one exemplary embodiment, the parameter calculating module includes: first time computing unit, for according to
The position of destination sample frame calculates the corresponding pulse-recurrence time interval of the destination sample frame；Second time calculating unit is used
Pulse interval is set in obtaining, and according to the setting pulse interval and the corresponding pulse weight of the destination sample frame
Multiple time interval, is calculated the corresponding pulse-recurrence time interval of virtual sample boxes and number；Position calculation unit is used for root
The position of virtual sample boxes is obtained according to the corresponding pulse-recurrence time interval calculation of virtual sample boxes；Parameter calculation unit is used for
Multiple emission parameters are calculated according to the number and position of virtual sample boxes.
In one exemplary embodiment, the signal processing module includes: demodulating unit, for believing collected echo
It number is demodulated, generates demodulated signal；Frequency offset correction unit, for estimating blood flow velocity to described according to human body target tissue
Demodulated signal carries out frequency offset correction, obtains the signal to be imaged.
In one exemplary embodiment, the demodulating unit includes: demodulation subelement, for according to effective frequency, demodulation frequency pair
Collected echo-signal is demodulated, and low-pass filter is called to be filtered, and generates the demodulated signal；Wherein, described
Effective frequency, demodulation frequency is related to the tranmitting frequency traversed in emission parameter.
In one exemplary embodiment, the frequency offset correction unit includes: Fourier transformation subelement, if for described
Human body target tissue estimates blood flow velocity within the scope of low velocity flow, then carries out at Fourier transformation to the demodulated signal
Reason；First calibration subelement is obtained for being calibrated according to calibration factor to the demodulated signal for completing Fourier transformation processing
The signal to be imaged.
In one exemplary embodiment, the frequency offset correction unit includes: set of frequency subelement, if being used for the people
Body destination organization estimates blood flow velocity within the scope of high speed blood flow, then is according to the tranmitting frequency in multiple emission parameters
Reference frequency is arranged in the frequency offset correction；Coordinate rotates computation subunit, for using CORDIC (Coordinate
Rotation Digital Computer, Coordinate Rotation Digital calculate) algorithm calculates the amplitude and phase of the demodulated signal
Angle, and the phase angle is converted according to the reference frequency；Third calibrate subelement, for according to calibration factor to turn
Phase angle after changing is calibrated, using the phase angle after the amplitude and calibration as the signal to be imaged.
The third aspect, a kind of Pulsed-Wave Doppler imaging device based on HPRF, including processor and memory, it is described to deposit
It is stored with computer-readable instruction on reservoir, is realized when the computer-readable instruction is executed by the processor as described above
Pulsed-Wave Doppler imaging method based on HPRF.
Fourth aspect, a kind of computer readable storage medium are stored thereon with computer program, the computer program quilt
The Pulsed-Wave Doppler imaging method based on HPRF as described above is realized when processor executes.
In the above-mentioned technical solutions, the transmitting that ultrasonic wave is carried out using different launch times and tranmitting frequency, is dropped with this
Influencing each other between low multiple transmitting, so that the echo-signal for effectively eliminating virtual sample boxes reflection is anti-to destination sample frame
The interference for the echo-signal penetrated solves Doppler shift information in the prior art and measures not accurate enough and influence HPRF imaging
The problem of energy.
It should be understood that above general description and following detailed description be only it is exemplary and explanatory, not
It can the limitation present invention.
Detailed description of the invention
The drawings herein are incorporated into the specification and forms part of this specification, and shows and meets implementation of the invention
Example, and in specification together principle for explaining the present invention.
Fig. 1 is the schematic diagram of related implementation environment according to the present invention.
Fig. 2 is a kind of hardware block diagram of medical ultrasound imaging equipment shown according to an exemplary embodiment.
Fig. 3 is a kind of process of Pulsed-Wave Doppler imaging method based on HPRF shown according to an exemplary embodiment
Figure.
Fig. 4 be in Fig. 3 corresponding embodiment step 310 in the flow chart of one embodiment.
Fig. 5 is the schematic diagram of destination sample frame and virtual sample boxes involved in Fig. 4 corresponding embodiment.
Fig. 6 be in Fig. 4 corresponding embodiment step 350 in the flow chart of one embodiment.
Fig. 7 be in Fig. 6 corresponding embodiment step 353 in the flow chart of one embodiment.
Fig. 8 be in Fig. 6 corresponding embodiment step 353 in the flow chart of another embodiment.
Fig. 9 is the stream of another Pulsed-Wave Doppler imaging method based on HPRF shown according to an exemplary embodiment
Cheng Tu.
Figure 10 is the schematic diagram of each sample boxes position involved in Fig. 9 corresponding embodiment.
Figure 11 is the schematic diagram of the transmitting timing of ultrasonic wave involved in Fig. 9 corresponding embodiment.
Figure 12 is that frequency spectrum corresponding to the first, second demodulated signal involved in Fig. 9 corresponding embodiment does not occur on frequency domain
The schematic diagram of aliasing.
Figure 13 is a kind of frame of Pulsed-Wave Doppler imaging device based on HPRF shown according to an exemplary embodiment
Figure.
Figure 14 is a kind of the hard of Pulsed-Wave Doppler imaging device based on HPRF shown according to an exemplary embodiment
Part structural block diagram.
Through the above attached drawings, it has been shown that the specific embodiment of the present invention will be hereinafter described in more detail, these attached drawings
It is not intended to limit the scope of the inventive concept in any manner with verbal description, but is by referring to specific embodiments
Those skilled in the art illustrate idea of the invention.
Specific embodiment
Here will the description is performed on the exemplary embodiment in detail, the example is illustrated in the accompanying drawings.Following description is related to
When attached drawing, unless otherwise indicated, the same numbers in different drawings indicate the same or similar elements.Following exemplary embodiment
Described in embodiment do not represent all embodiments consistented with the present invention.On the contrary, they be only with it is such as appended
The example of device and method being described in detail in claims, some aspects of the invention are consistent.
Fig. 1 is a kind of schematic diagram of implementation environment involved in Pulsed-Wave Doppler imaging method based on HPRF.The reality
Applying environment includes user 110, medical ultrasound imaging equipment 130 and its ultrasonic Doppler transducer 150 carried.
Wherein, medical ultrasound imaging equipment 130 refers to the electronics for implementing Pulsed-Wave Doppler imaging by transmitting ultrasonic wave
Equipment, for example, B ultrasound machine, prison instrument instrument, doppler ultrasound etc., herein without limiting.
It first passes through wireless between medical ultrasound imaging equipment 130 and its doppler transducer 150 carried or wired builds in advance
Vertical communication connection, to realize signal transmission based on this communication connection.For example, the signal of transmission can be ultrasonic wave, echo-signal
Etc..
With the interaction between medical ultrasound imaging equipment 130 and ultrasonic Doppler transducer 130, when doppler transducer 130
Emit ultrasonic wave to user 110, the measurement of blood flow variation is carried out with the human body target tissue to this user 110, for doctor
For supersonic imaging apparatus 130, the echo-signal reflected via the human body target tissue of user 110 can be received, into
And Doppler shift information is measured according to echo-signal, thus complete Pulsed-Wave Doppler imaging process.
Fig. 2 is a kind of hardware block diagram of medical ultrasound imaging equipment shown according to an exemplary embodiment.This doctor
It is suitable for implementation environment shown in figure 1 with supersonic imaging apparatus, for realizing the Pulsed-Wave Doppler imaging side based on HPRF
Method.
It should be noted that this medical ultrasound imaging equipment, which is one, adapts to example of the invention, it is not construed as
Provide any restrictions to use scope of the invention.This medical ultrasound imaging equipment can not be construed to need to rely on or
Person must have one or more component in illustrative medical ultrasound imaging equipment 200 shown in Figure 2.
The hardware configuration of this medical ultrasound imaging equipment 200 can generate biggish difference due to the difference of configuration or performance
It is different, as shown in Fig. 2, medical ultrasound imaging equipment 200 includes: power supply 210, interface 230, an at least memory 250 and at least
One central processing unit (CPU, Central Processing Units) 270.
Wherein, power supply 210 is used to provide operating voltage for each hardware device in medical ultrasound imaging equipment 200.
Interface 230 includes an at least wired or wireless network interface 231, at least a string and translation interface 233, at least one defeated
Enter output interface 235 and at least USB interface 237 etc., is used for and external device communication.
The carrier that memory 250 is stored as resource, it is understood that be computer readable storage medium, including but not
It is limited to read-only memory, random access memory, disk or CD etc., the resource stored thereon includes operating system 251, calculates
Machine program 253 and data 255 etc., storage mode can be of short duration storage or permanently store.Wherein, operating system 251 is used for
Management and each hardware device and computer program 253 in control medical ultrasound imaging equipment 200, to realize central processing unit
The calculating and processing of 270 pairs of mass datas 255, can be Windows ServerTM, Mac OS XTM, UnixTM,
LinuxTM, FreeBSDTM etc..Computer program 253 is based at least one of completion particular job on operating system 251
Computer program, may include an at least instruction module (not showing that in Fig. 2), and each module can separately include pair
The series of computation machine readable instruction of medical ultrasound imaging equipment 200.Data 255 can be stored in photo, figure in disk
Piece etc..
Central processing unit 270 may include the processor of one or more or more, and be set as through bus and memory
250 communications, for the mass data 255 in operation and processing memory 250.
As described in detail above, being applicable in medical ultrasound imaging equipment 200 of the invention will be by central processing unit 270
The series of computation machine read in the computer program 253 stored in computer readable storage medium (i.e. memory 250) is readable
Instruction is to complete the Pulsed-Wave Doppler imaging method based on HPRF.
In addition, also can equally realize the present invention by hardware circuit or hardware circuit combination software, therefore, this hair is realized
The bright combination for being not limited to any specific hardware circuit, software and the two.
Referring to Fig. 3, in one exemplary embodiment, a kind of Pulsed-Wave Doppler imaging method based on HPRF is suitable for
The structure of the medical ultrasound imaging equipment of implementation environment shown in Fig. 1, the medical ultrasound imaging equipment can be as shown in Figure 2.
Pulsed-Wave Doppler imaging method of this kind based on HPRF can be executed by medical ultrasound imaging equipment, may include
Following steps:
Step 310, multiple emission parameters are calculated according to the position of destination sample frame.
Firstly, destination sample frame, refers to that human body target group is woven in the position in human body.Correspondingly, virtual sample boxes are then
Refer to other depth locations in human body, not human body target group is woven in the position in human body.
Secondly, each emission parameter includes different launch times and tranmitting frequency.
In an embodiment in the specific implementation, as shown in figure 4, step 310 may comprise steps of:
Step 311, the corresponding pulse-recurrence time interval of destination sample frame is calculated according to the position of destination sample frame.
Step 313, setting pulse interval is obtained, and corresponding according to setting pulse interval and destination sample frame
The corresponding pulse-recurrence time interval of virtual sample boxes and number is calculated in pulse-recurrence time interval.
It is appreciated that pulse-recurrence time interval, corresponds to destination sample frame or virtual sample boxes, refer to for same
The position of one sample boxes, the Fixed Time Interval of repeat its transmission ultrasonic wave.
Pulse interval (Pulse Repeat Time, PRT), is different from pulse-recurrence time interval, then refers to adjacent
Between the position of two sample boxes, the time interval of ultrasonic wave round trip.
In the present embodiment, pulse interval be it is pre-set, i.e., setting pulse interval.
In order to set the acquisition of pulse interval, medical ultrasound imaging equipment provides an inlet porting for user, if
User's expectation presets pulse interval, can be by triggering relevant operation in this inlet porting, and then passes through this phase
Operation is closed so that medical ultrasound imaging equipment knows the pre-set pulse interval of user.
Step 315, the position of virtual sample boxes is obtained according to the corresponding pulse-recurrence time interval calculation of virtual sample boxes.
Step 317, multiple emission parameters are calculated according to the number and position of virtual sample boxes.
Specifically, the calculating process of emission parameter is as follows:
BPRT=2*Depth/C (1).
Wherein, Depth indicates that human body target group is woven in the depth in human body, the i.e. position of destination sample frame, and C indicates super
Spread speed of the sound wave in human body target tissue, BPRT then indicate the corresponding pulse-recurrence time interval of destination sample frame.
Wherein, DPRT indicates that setting pulse interval, Nv indicate the number of virtual sample boxes.
VPRT=(Nv-1) * DPRT+BPRT-Nv*DPRT (3.1),
As shown in figure 5, VPRT indicates the corresponding pulse-recurrence time interval virtual sample boxes V0, DPRT indicates setting arteries and veins
Time interval is rushed, then VPRTNv-n+1Then indicate virtual sample boxes V1, V2, V3 ..., VNCorresponding pulse-recurrence time interval.
It further, can be according to calculation formula after knowing the corresponding pulse-recurrence time interval of virtual sample boxes
(4) the anti-position for pushing away virtual sample boxes:
VPRTn=2*Depthn/C (4)。
Wherein, VPRTnIndicate the corresponding pulse-recurrence time interval of n-th of virtual sample boxes, DepthnIndicate human body in its
His depth location, i.e., the position of virtual sample boxes, C indicate spread speed of the ultrasonic wave in human body target tissue.
After the number and position for obtaining virtual sample boxes, it can be arranged according to the number of virtual sample boxes and position super
The transmitting timing of sound wave.
Specifically, the number N of different tranmitting frequencies is setf>=Nv+1.Easy to calculate, in the present embodiment, setting is different
The number of tranmitting frequency is Nf=Nv+ 1, wherein Nv indicates the number of virtual sample boxes.
The setting of different tranmitting frequencies be on reduce as much as possible repeatedly transmitting between influence each other premised on.
For example, the centre frequency of setting transmitting ultrasonic wave, i.e. tranmitting frequency are fi, then need to meet fi-fi-1> 2PRF,
In, PRF indicates (i-1)-th pulse recurrence frequency, related with the position of virtual sample boxes.
Further, with the measurement of Doppler shift information, the centre frequency for emitting ultrasonic wave each time can be correspondingly
Adjustment guarantees that spectral aliasing will not occur on frequency domain for doppler imaging with this, guarantees the accurate of Doppler shift information measurement
Property, and then improve HPRF imaging performance.
Step 330, multiple emission parameters are traversed, and are sent out according to the launch time traversed in emission parameter and tranmitting frequency
Ultrasonic wave is penetrated to the virtual sample boxes of destination sample frame and at least one, carries out echo wave signal acquisition.
That is, for the emission parameter traversed, it is assumed that there are n-1 virtual sample boxes, then, it collects every time
Echo-signal substantially contain n reflection echo-signal stack result, i.e. 1 destination sample frame reflection echo
Signal and the echo-signal of n-1 virtual sample boxes reflections.
It is also understood that collected echo-signal is substantially to surpass according to what n kind difference tranmitting frequency emitted every time
The stack result for the echo-signal that sound wave is reflected via corresponding sample boxes.
Step 350, signal processing is carried out to collected echo-signal, obtains signal to be imaged.
Signal processing includes but is not limited to: demodulation, filtering and frequency offset correction etc..
In an embodiment in the specific implementation, as shown in fig. 6, step 350 may comprise steps of:
Step 351, collected echo-signal is demodulated, generates demodulated signal.
Specifically, collected echo-signal is demodulated according to effective frequency, demodulation frequency, and call low-pass filter into
Row filtering, generates demodulated signal.
Wherein, effective frequency, demodulation frequency is related to the tranmitting frequency traversed in emission parameter.
It is appreciated that the position due to each sample boxes is different, for the ultrasonic wave of same tranmitting frequency transmitting, via each
The time that the echo-signal of sample boxes reflection reaches medical ultrasound imaging equipment is different.
For example, as shown in figure 5, for the ultrasonic wave when the transmitting of previous tranmitting frequency, medical ultrasound imaging equipment
Then the echo-signal for collecting virtual sample boxes V3 reflection first collects the echo-signal of virtual sample boxes V2 reflection, with
This analogizes, and finally collects the echo-signal of destination sample frame reflection.
The circulation transmitting that emission parameter carries out ultrasonic wave is traversed, it is medical for the ultrasonic wave of the latter tranmitting frequency transmitting
Supersonic imaging apparatus collects the echo-signal ... ... of virtual sample boxes V3 reflection first, and it is anti-finally to collect destination sample frame
The echo-signal penetrated.
In other words, for same acquisition time, collected echo-signal for different tranmitting frequencies.Cause
This, effective acquisition of signal each time will be using the echo-signal for collecting the reflection of destination sample frame as measurement standard.
It correspondingly, is that the centre frequency of the echo-signal reflected using destination sample frame is demodulated as effective in signal demodulation
Frequency, it is understood that be that, when the tranmitting frequency traversed in emission parameter transmits ultrasonic wave, this ultrasonic wave is adopted via target
When the echo-signal of sample frame reflection is collected, it is effective frequency, demodulation frequency that this, which traverses the tranmitting frequency in emission parameter,.
In other words, demodulating process, essence also experienced the traversal of emission parameter, i.e., basis traverses in emission parameter
Tranmitting frequency is arranged effective frequency, demodulation frequency.
Step 353, according to human body target tissue estimate blood flow velocity to demodulated signal carry out frequency offset correction, obtain at
As signal.
It should be appreciated that using ultrasonic measurement blood flow velocity, substantially measurement human body target tissue is due to blood flow
The Doppler shift information of generation, and then estimate blood flow velocity.
Specifically, ultrasonic wave is by occurring Doppler frequency shift phenomenon, frequency deviation f after human body target Tissue reflectancedCalculating
Formula (5) is as follows:
fd=2v/C*f0*cos a (5)。
Wherein, f0Indicate the centre frequency of transmitting ultrasonic wave, i.e. tranmitting frequency, a indicates ultrasonic wave in human body target tissue
In the direction of propagation and human body target tissue in angle between direction of flow of blood, v indicates blood flow velocity, and C indicates ultrasonic wave
Spread speed in human body target tissue.
By calculation formula (5) it is found that if tranmitting frequency f0Difference, though in human body target tissue the direction of blood flow and
Speed is identical, will also generate different frequency deviation fd。
For this reason, it may be necessary to eliminate the influence of different frequency deviations caused by it for different tranmitting frequencies, i.e., demodulated signal is carried out
Frequency offset correction.
Further, it as previously mentioned, when blood flow velocity is high in human body target tissue, generally requires higher pulse and repeats frequency
Rate, therefore, under the premise of meeting nyquist sampling law, requirement of the different blood flow velocity to pulse recurrence frequency is
Difference, then it is also different for the frequency offset correction mode of different pulse repetition.
Need to estimate the blood flow velocity in human body target tissue before carrying out frequency offset correction to demodulated signal based on this,
In order to select corresponding frequency offset correction mode.
In one embodiment, blood flow velocity estimation can be carried out according to human body target tissue set by user.For example, working as people
When body destination organization is heart aorta, estimating blood flow velocity is 18-22cm/s, when human body target tissue is vena cave, in advance
Estimating blood flow velocity is 7-8cm/s, and when human body target tissue is capillary, estimating blood flow velocity is 0.3-0.7mm/s.Another
In one embodiment, blood flow velocity estimation can also be distributed to estimate according to the Doppler frequency shift of echo-signal.
Step 370, it completes to traverse to multiple emission parameters, frequency spectrum processing imaging is carried out to multichannel signal to be imaged.
Wherein, an emission parameter is corresponded to per signal to be imaged all the way.
Frequency spectrum processing imaging, substantially according to the Doppler frequency shift of echo-signal be distributed measure human body target tissue because
Blood flow and the Doppler shift information generated, and then corresponding pulse wave spectrum is shown in medical ultrasound imaging equipment,
Reflect that the blood flow in human body target tissue changes with this.
By process as described above, the blood distribution at virtual sample boxes position has been effective filtered out to destination sample frame
The influence of blood distribution at position, to improve HPRF imaging performance.
Referring to Fig. 7, in one exemplary embodiment, step 353 may comprise steps of:
Step 3531, if human body target tissue estimates blood flow velocity within the scope of low velocity flow, to demodulated signal
Carry out Fourier transformation processing.
Step 3533, according to calibration factor to complete Fourier transformation processing demodulated signal calibrate, obtain at
As signal.
Specifically, if human body target tissue estimates blood flow velocity within the scope of low velocity flow, that is, it is considered as human body target
Blood flow velocity in tissue is lower, and correspondingly, pulse recurrence frequency can be slightly lower.Wherein, low velocity flow range, according to application scenarios
Actual demand can neatly adjust, herein without limit.
In order to meet nyquist sampling law, pulse recurrence frequency is at least 2fd.Wherein, fdIndicate frequency deviation.
It is considered as the sample frequency of echo-signal based on pulse recurrence frequency as a result, for the blood flow compared with low speed, when pulse weight
Complex frequency is the N of nyquist sampling ratefTimes or more when, then pass through NfThe searching loop of a emission parameter, can be obtained NfLu Xie
Signal is adjusted, is handled for per demodulated signal complete independently Fourier transformation all the way, then is multiplied with calibration factor to be imaged to get arriving
Signal.
Wherein, calibration factor f0/fi_demo, fi_demoEffective JieDuHuaYu II Decoction when for the road i-th _ demo+1 demodulation signal processing
Rate, effective frequency, demodulation frequency when f0 is the 1st tunnel demodulation signal processing.
Referring to Fig. 8, in a further exemplary embodiment, step 353 may comprise steps of:
Step 3532, if human body target tissue estimates blood flow velocity within the scope of high speed blood flow, according to multiple hairs
The tranmitting frequency penetrated in parameter is that reference frequency is arranged in frequency offset correction.
Step 3534, amplitude and the phase angle of demodulated signal are calculated using cordic algorithm, and according to reference frequency to phase
Parallactic angle is converted.
Step 3536, the phase angle after conversion is calibrated according to calibration factor, by the phase angle after amplitude and calibration
As signal to be imaged.
Specifically, if human body target tissue estimates blood flow velocity within the scope of high speed blood flow, that is, it is considered as human body target
Blood flow velocity in tissue is higher, and correspondingly, pulse recurrence frequency is higher.Wherein, high speed blood flow range, according to application scenarios
Actual demand can be adjusted neatly, herein without limiting.
In order to meet nyquist sampling law, pulse recurrence frequency is at least 2fd.Wherein, fdIndicate frequency deviation.
It is considered as the sample frequency of echo-signal based on pulse recurrence frequency as a result, for the blood flow of higher speed, pulse is repeated
Frequency is simultaneously unsatisfactory for as the N of nyquist sampling ratefTimes or more.
For this purpose, the demodulated signal under different effectively frequency, demodulation frequencies is calibrated to single effective frequency, demodulation frequency in the present embodiment
Under, i.e., an effective frequency, demodulation frequency is chosen from multiple effective frequency, demodulation frequencies as reference frequency.
Since effective frequency, demodulation frequency is substantially the tranmitting frequency in emission parameter, so, reference frequency is some transmitting
Tranmitting frequency in parameter.
Emit ultrasonic wave for periodic cycle is carried out according to different tranmitting frequencies, sent out in a cycle for the first time
The centre frequency for the ultrasonic wave penetrated, i.e. first tranmitting frequency f0As being illustrated for reference frequency.
Assuming that demodulated signal includes IQ two-way, then demodulated signal such as calculation formula (6.1), (6.2) are shown.
Coordinate rotation is carried out to demodulated signal using cordic algorithm, it is E that the corresponding amplitude of demodulated signal, which is calculated,
(t), phase angle is
According to the phase angle E (t) and calibration factor being calculatedIt is multiplied, so that it may the phase angle after being calibrated
2πfd00T, further according to the 2 π fd of phase angle after amplitude E (t) and calibration00T, which can be obtained, is transformed into reference frequency f0Letter to be imaged
Number:And
By the above process, different blood flow velocity are realized and correspond to different frequency offset correction modes, are meeting Nyquist
Under the premise of Sampling Theorem, the accuracy of frequency offset correction is effectively improved, and then is conducive to improve Doppler shift information
Accuracy fully ensures that the imaging performance of HPRF.
Referring to Fig. 9, in a further exemplary embodiment, a kind of Pulsed-Wave Doppler imaging method based on HPRF can be with
It is executed by medical ultrasound imaging equipment, this medical ultrasound imaging equipment is based on by executing step 610 to step 650 with realizing
The Pulsed-Wave Doppler imaging method of HPRF.
For ease of illustration, in the present embodiment, destination sample frame and virtual sample boxes are respectively 1, and the position of each sample boxes is such as
Shown in Figure 10.
Correspondingly, emission parameter is 2, and the tranmitting frequency separately included is f0 and f1 and ultrasonic wave according to upper
It is as shown in figure 11 to state the transmitting timing that 2 emission parameters are emitted.It is appreciated that between the time between ultrasonic wave transmitting twice
Every as PRT (pulse interval).
Wherein, f1With f0Between need to meet as shown in Figure 12, aliasing does not occur for two parts of signals frequency spectrum.
It should be noted that because the ultrasonic wave of transmitting just reaches destination sample frame for the first time after emitting for second
Position, that is to say, that just start effectively to receive the echo-signal reflected from destination sample frame after second of transmitting, therefore, hair
Radio frequency rate is f1Later, received echo-signal is with tranmitting frequency f0It is demodulated as effective frequency, demodulation frequency.Similarly, it sends out
Radio frequency rate is f0Later, received echo-signal is with tranmitting frequency f1It is demodulated as effective frequency, demodulation frequency.
In other words, after second of transmitting, the echo-signal reflected from destination sample frame is just contained in echo-signal, therefore
And start effectively to receive for the first time.
Specifically, it effectively receives for the first time, echo-signal is as follows:
x0(t)=A (t) cos (2 π (f0+fd00)t)+B(t)cos(2π(f1+fd11)t) (7)。
Wherein, A (t) cos (2 π (f0+fd00) t) indicate the echo-signal reflected from destination sample frame,
B(t)cos(2π(f1+fd11) t) indicate the echo-signal reflected from virtual sample boxes,
Indicate that the ultrasonic wave that tranmitting frequency is f0 reflects generated frequency deviation through destination sample frame,Indicate that the ultrasonic wave that tranmitting frequency is f1 reflects generated frequency deviation through destination sample frame.
Second of effectively reception, echo-signal is as follows:
x1(t)=A (t) cos (2 π (f1+fd10)t)+B(t)cos(2π(f0+fd01)t)(8)。
Wherein,The ultrasonic wave that expression tranmitting frequency is f1 is through caused by the reflection of destination sample frame
Frequency deviation,Indicate that the ultrasonic wave that tranmitting frequency is f0 reflects generated frequency deviation through destination sample frame.
It effectively receives for the first time, using effective frequency, demodulation frequency f0It is demodulated, is obtained after demodulation:
After filtering by low-pass filter, the IQ two-way of demodulated signal is expressed as follows:
Second of effectively reception, using effective frequency, demodulation frequency f1It is demodulated, is obtained after demodulation:
After filtering by low-pass filter, the IQ two-way of demodulated signal is expressed as follows:
Because being periodic cycle transmitting ultrasonic wave, so, in the present embodiment, subsequent third time, the 5th time, the 7th
Secondary ... it effectively receives and uses for the first time effective frequency, demodulation frequency used in effectively reception；Subsequent 4th time, the 6th time,
8th time ... it effectively receives and uses effective frequency, demodulation frequency used in second of effective reception, herein not repeated description.
When two in above-mentioned calculation formula (9.1), (9.2), (10.1), (10.2) on the right of equation do not occur on frequency domain
When aliasing, so that it may effectively filter out blood flow signal at virtual sample boxes position and be done to blood flow signal at destination sample frame position
It disturbs, as shown in figure 12.
Conversely, being then adjusted to tranmitting frequency f0 and f1.
Further, if estimating the demodulated signal progress that can be formed for effective reception each time for the blood flow compared with low speed
Then FFT carries out frequency offset correction according to calibration factor.
If estimating the blood flow for higher speed, needing to calibrate to the demodulated signal under different effectively frequency, demodulation frequencies single has
It imitates under frequency, demodulation frequency, to carry out frequency offset correction according to calibration factor based on reference frequency.
Further, frequency spectrum processing imaging is carried out to by the signal to be imaged of frequency offset correction, is achieved in and is based on
The Pulsed-Wave Doppler of HPRF is imaged.
During the realization of the present embodiment, the blood distribution at virtual sample boxes position is effective filtered out and target has been adopted
The influence of blood distribution at sample frame position, to improve HPRF imaging performance.
Following is apparatus of the present invention embodiment, how general can be used for executing the impulse wave according to the present invention based on HPRF
Strangle imaging method.For undisclosed details in apparatus of the present invention embodiment, please refer to according to the present invention based on HPRF's
The embodiment of the method for Pulsed-Wave Doppler imaging method.
Figure 13 is please referred to, in one exemplary embodiment, a kind of packet of Pulsed-Wave Doppler imaging device 900 based on HPRF
It includes but is not limited to: parameter calculating module 910, ultrasonic wave transmitting module 930, signal processing module 950 and spectral imaging module
970。
Wherein, parameter calculating module 910 is used to calculate multiple emission parameters, each transmitting according to the position of destination sample frame
Parameter includes different launch times and tranmitting frequency.
Ultrasonic wave transmitting module 930 is for traversing multiple emission parameters, and when according to the transmitting traversed in emission parameter
Between and tranmitting frequency emit ultrasonic wave to the virtual sample boxes of destination sample frame and at least one, progress echo wave signal acquisition.
Signal processing module 950 is used to carry out signal processing to collected echo-signal, obtains signal to be imaged.
Spectral imaging module 970 is used to complete to traverse to multiple emission parameters, carries out at frequency spectrum to multichannel signal to be imaged
Reason imaging, an emission parameter is corresponded to per signal to be imaged all the way.
It should be noted that the Pulsed-Wave Doppler imaging device based on HPRF provided by above-described embodiment is carrying out base
When the Pulsed-Wave Doppler imaging of HPRF, only the example of the division of the above functional modules, practical application
In, it can according to need and be completed by different functional modules above-mentioned function distribution, i.e., based on the Pulsed-Wave Doppler of HPRF
The internal structure of imaging device will be divided into different functional modules, to complete all or part of the functions described above.
In addition, the Pulsed-Wave Doppler imaging device provided by above-described embodiment based on HPRF and the arteries and veins based on HPRF
The embodiment for rushing wave Doppler imaging method belongs to same design, and wherein modules execute the concrete mode of operation in side
It is described in detail in method embodiment, details are not described herein again.
Figure 14 is please referred to, in one exemplary embodiment, a kind of Pulsed-Wave Doppler imaging device 1000 based on HPRF,
Including an at least processor 1001, at least a memory 1002 and an at least communication bus 1003.
Wherein, computer-readable instruction is at least stored on a memory 1002, an at least processor 1001 is by least
One communication bus 1003 reads the computer-readable instruction of this memory 1002 storage.
The arteries and veins based on HPRF in the various embodiments described above is realized when the computer-readable instruction is executed by this processor 1001
Rush wave Doppler imaging method.
In one exemplary embodiment, a kind of computer readable storage medium 250, is stored thereon with computer program 253,
As shown in Fig. 2, realizing that the impulse wave based on HPRF in the various embodiments described above is more when the computer program is executed by processor 270
General Le imaging method.
Above content, preferable examples embodiment only of the invention, is not intended to limit embodiment of the present invention, this
Field those of ordinary skill central scope according to the present invention and spirit can be carried out very easily corresponding flexible or repaired
Change, therefore protection scope of the present invention should be subject to protection scope required by claims.
Claims (10)
1. a kind of Pulsed-Wave Doppler imaging method based on HPRF characterized by comprising
Multiple emission parameters are calculated according to the position of destination sample frame, each emission parameter includes different launch times and transmitting
Frequency；
Multiple emission parameters are traversed, and emits according to the launch time traversed in the emission parameter and tranmitting frequency and surpasses
Sound wave carries out echo wave signal acquisition to the virtual sample boxes of destination sample frame and at least one；
Signal processing is carried out to collected echo-signal, obtains signal to be imaged；
Traversal is completed to multiple emission parameters, the signal progress frequency spectrum processing imaging to be imaged described in multichannel, per institute all the way
Signal to be imaged is stated corresponding to an emission parameter.
2. the method as described in claim 1, which is characterized in that the method also includes:
If aliasing occurs on frequency domain for frequency spectrum corresponding to frequency spectrum corresponding to the first demodulated signal and at least one second demodulated signal,
Then the tranmitting frequency in multiple emission parameters is adjusted；
Wherein, first demodulated signal is generated by the echo-signal demodulation of destination sample frame reflection, at least described in one
Second demodulated signal is generated by the echo-signal demodulation of at least one virtual sample boxes reflection.
3. method according to claim 1 or 2, which is characterized in that described to calculate multiple hairs according to the position of destination sample frame
Penetrate parameter, comprising:
The corresponding pulse-recurrence time interval of the destination sample frame is calculated according to the position of the destination sample frame；
Setting pulse interval is obtained, and according to the setting pulse interval and the corresponding pulse of the destination sample frame
The corresponding pulse-recurrence time interval of virtual sample boxes and number is calculated in repetition interval；
The position of virtual sample boxes is obtained according to the corresponding pulse-recurrence time interval calculation of virtual sample boxes；
Multiple emission parameters are calculated according to the number and position of virtual sample boxes.
4. method according to claim 1 or 2, which is characterized in that it is described that signal processing is carried out to collected echo-signal,
Obtain signal to be imaged, comprising:
Collected echo-signal is demodulated, demodulated signal is generated；
Frequency offset correction is carried out to the demodulated signal according to the blood flow velocity of estimating of human body target tissue, obtains the letter to be imaged
Number.
5. method as claimed in claim 4, which is characterized in that it is described that collected echo-signal is demodulated, generate solution
Adjust signal, comprising:
Collected echo-signal is demodulated according to effective frequency, demodulation frequency, and low-pass filter is called to be filtered, is generated
The demodulated signal；
Wherein, effective frequency, demodulation frequency is related to the tranmitting frequency traversed in emission parameter.
6. method as claimed in claim 4, which is characterized in that described to estimate blood flow velocity to institute according to human body target tissue
It states demodulated signal and carries out frequency offset correction, obtain the signal to be imaged, comprising:
If the human body target tissue estimates blood flow velocity within the scope of low velocity flow, Fu is carried out to the demodulated signal
In leaf transformation handle；
The demodulated signal for completing Fourier transformation processing is calibrated according to calibration factor, obtains the signal to be imaged.
7. method as claimed in claim 4, which is characterized in that described to estimate blood flow velocity to institute according to human body target tissue
It states demodulated signal and carries out frequency offset correction, obtain the signal to be imaged, comprising:
If the human body target tissue estimates blood flow velocity within the scope of high speed blood flow, according to multiple emission parameters
In tranmitting frequency be the frequency offset correction be arranged reference frequency；
Amplitude and the phase angle of the demodulated signal are calculated using cordic algorithm, and according to the reference frequency to the phase
It is converted at angle；
The phase angle after conversion is calibrated according to calibration factor, using the amplitude and calibration after phase angle as described in
Imaging signal.
8. a kind of Pulsed-Wave Doppler imaging device based on HPRF characterized by comprising
Parameter calculating module, for calculating multiple emission parameters according to the position of destination sample frame, each emission parameter includes not
Same launch time and tranmitting frequency；
Ultrasonic wave transmitting module, for traversing multiple emission parameters, and according to the transmitting traversed in the emission parameter
Time and tranmitting frequency emit ultrasonic wave to the virtual sample boxes of destination sample frame and at least one, carry out echo wave signal acquisition；
Signal processing module obtains signal to be imaged for carrying out signal processing to collected echo-signal；
Spectral imaging module, for completing traversal to multiple emission parameters, the signal progress frequency spectrum to be imaged described in multichannel
Processing imaging, an emission parameter is corresponded to per the signal to be imaged described all the way.
9. a kind of Pulsed-Wave Doppler imaging device based on HPRF characterized by comprising
Processor；And
Memory is stored with computer-readable instruction on the memory, and the computer-readable instruction is held by the processor
The Pulsed-Wave Doppler imaging method based on HPRF as described in any one of claims 1 to 7 is realized when row.
10. a kind of computer readable storage medium, is stored thereon with computer program, which is characterized in that the computer program
The Pulsed-Wave Doppler imaging method based on HPRF as described in any one of claims 1 to 7 is realized when being executed by processor.
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