CN1091952A - Cosmetic composition - Google Patents
Cosmetic composition Download PDFInfo
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- CN1091952A CN1091952A CN93119716A CN93119716A CN1091952A CN 1091952 A CN1091952 A CN 1091952A CN 93119716 A CN93119716 A CN 93119716A CN 93119716 A CN93119716 A CN 93119716A CN 1091952 A CN1091952 A CN 1091952A
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- arginine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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Abstract
The part is used for mammal skin or hair, the particularly bald or cosmetic composition on bald people's scalp just, and it contains the metabolism intermediate of the ornithine cycle that can be used as trichogenous activating agent, or the derivant of described metabolism intermediate.
Description
The present invention relates to cosmetic composition, it can be used for mammalian skin or hair in the part, to increase or to keep hair growth at least, particularly can make terminal hair (terminal hair) growth on people's scalp.
In recent years, people are to promoting, increase or keeping the normal growth of people's hair to give very high attention at least, the male that those hairs are begun to come off particularly, and it is bald to resemble typical male, or resembling those with age, hair begins thinning thin masculinity and femininity.For this reason, the market of " hair restorer " or " controlling the alopecia medicine " enlarges day by day.
Confirm that fully in most of mammals, comprise the people, hair is not a continuous growth, but experienced an active circulation, the alternately phase of promptly growing and stopping.The hair growth circulation can be divided into three Main Stage, that is:
ⅰ) be called the operational phase of trophophase, hair follicle penetrates with corium during this, and glomus cell divides fast and is differentiated to form hair,
ⅱ) be called the catagen phase of catagen, indicating that mitosis stops, and folliculus upwards sees through corium and degenerates during this, and hair stops growing and
ⅲ) be called the rest stage of resting stage, during, the folliculus of degeneration comprises the little secondary embryo of the substrate ball that has the dermal papilla cell that closely enriches.
Metabolism during the hair follicle growth still fails to understand well.Hair follicle through microdissection is verified, and glucose is the required main nutriment of hair follicle normal growth, and the glucose major part is not oxidized, but is converted into lactate.[see, for example, Adachi K, the glucose metabolism of the Uno H. growth and the hair follicle that stops, Am J Physiol(1968) 215,1234-1239; With Philpott M P, kealey T, the metabolism research of the hair follicle that exsomatizes.J Envest Derm（1991）96，875-879]。
In nearest major part work, we have shockingly proved the lipid fuel seldom of hair follicle metabolism.And glutamine has become main nutriment, and it can produce and the as many energy of glucose hair follicle.This part is operated in EP 490 581(Unilever) in narration is arranged, our verified glutamine linear ratio of stimulating hair growth to a great extent wherein.This shows that glutamy aminolysis (glutaminolysis) is an important metabolic process of hair growth.
By the further research to the glutamy aminolysis, we find now, change into glutamic acid and deutero-amine moiety wherein 2/3rds can not be explained ammonification from glutamine.Therefore, we observe its possible outcome other metabolic process by checking human hair follicle, our hypothesis, and one of them is: superfluous 1/2nd amine or its part are eliminated in folliculus by functional ornithine cycle.
Ornithine cycle is that to the importance of hair growth it can be created on energy-producing important intermediate in the folliculus, and same, it can also increase the efficient of glutamy aminolysis.Illustrate and see Fig. 1.
From this chain circulation as can be seen: specific intermediate plays an important role during promoting the glutamy aminolysis.Therefore, citrulline can contract with aspartic acid and generate argininosuccinic acid, and simultaneously, citrulline also can be by its effectiveness, and it depends on oxaloacetic acid and tricarboxylic acid cycle intermediate, regulates the synthetic of arginine/carbamide.
Arginine is owing to be essential amino acids, and its effectiveness also is important for ribonucleic acid and proteinic biosynthesis.The importance of ornithine is that the generation to arginine rather than carbamide has played effect in folliculus.In this process, the fumaric acid of generation can enter tricarboxylic acid cycle and can promote anaplerotic reaction.Do not have ornithine and arginine, the ammonia that the unnecessary nitrogen that is generated by the glutamy aminolysis forms can cause poisoning, and has proved already, because it suppresses transaminase's reaction and high glutamine blood and the fatal influence of cellular function generation.
Now, we have been used for this hypothesis experiment and have found: local application contains the compositions of the metabolism intermediate of ornithine cycle, can cause that the increase of hair growth surpasses the previous glutamine of observing.
Therefore, the present invention relates to use these intermediate in hair follicle metabolism, to increase or the maintenance hair growth.
Briefly say, the invention provides a kind of compositions, it is fit to be locally applied on mammalian skin or the hair to increase, to increase or to keep hair growth.Described compositions comprises:
ⅰ) the metabolism intermediate of the ornithine cycle of effective dose, they are selected from arginine, ornithine, citrulline, argininosuccinic acid and their salt, protic acid salt (hydrosalts) and precursor and their mixture; With
ⅱ) acceptable excipient on the cosmetics for this intermediate.
On the other hand, the invention provides with such compositions and increase, increase or keep the method for hair growth.But local application during use is especially for bald or just on bald people's scalp.
The ornithine cycle intermediate
The metabolism intermediate of the ornithine cycle part that the present invention relates to or the application of this metabolism midbody derivant, and in order to increase or to keep the topical application of the growth of the hair on hair growth, particularly the people's scalp.
Fig. 1 has illustrated ornithine cycle and has participated in glutamy aminolysis (extremely important in hair growth) by tricarboxylic acid cycle (TCA).Thus, select four metabolism intermediate of ornithine cycle, i.e. arginine, ornithine, citrulline and argininosuccinic acid, they more can improve linear hair growth than glutamine itself to a certain extent.
Therefore, among these four metabolism intermediate each can be joined in the compositions, be used on skin or the hair, particularly scalp, increase or keep hair growth at least with the part.
Generally, use simple derivant, the suitable salt and the protic acid salt that resemble these metabolism intermediate may and be more convenient really also.Particularly preferred salt for example is sodium salt, and protic acid salt is hydrohalide preferably, particularly the hydrochlorinate derivant of these intermediate.
Other derivant of also available these metabolism intermediate comprises acyl group, ester and peptide derivant.These also can be used as salt and protic acid salt.
More particularly, can use as following structure (1) to the derivant shown in the structure (4).The sign an undertaking arginine derivative of structure (1):
The sign an undertaking ornithine derivative of structure (2):
The sign an undertaking citrulline derivant of structure (3):
The sign an undertaking argininosuccinic acid derivant of structure (4):
Wherein, R
1Be selected from:
（ⅰ）H-，
（ⅲ）CxHy，
(ⅳ) amino acid residue, or the amino acid residue that replaces, wherein arbitrary free-NH
2Base is modified-NHCOCxHy or-the NHCxHy group, and/or arbitrary free-the COOH base is replaced to COOR
2Base and
(ⅴ) comprise the peptide residue of the amino acid residue of 2-8 amino acid residue or replacement, its replace such as above (ⅳ) definition;
Here the amino acid residue of Ding Yi amino acid residue or replacement is amino acid whosely derived one or more from following:
The L-α-Bing Ansuan, L-Beta-alanine, L-arginine, L-γ-An Jidingsuan, altheine, L-aspartic acid, L-citrulline, L-cysteine, the L-cystine, L-3,4-dihydroxyphenylalanine (DOPA), L-glutaminate, L-glutamic acid, L-glycine, L-histidine, the L-homoserine, L-oxylysine, L-hydroxyproline, the L-isoleucine, L-leucine, L-lysine, the L-methionine, L-ornithine, L-phenylalanine, the L-proline, L-serine, L-threonine, L-N, N, N-trimethyl glycine (betanin), the L-tryptophan, L-tyrosine and L-valine;
Each R
2Be selected from:
（ⅰ）H
+;
(ⅱ) be selected from Na
+And K
+Alkali metal cation,
(ⅲ) NH
+ 4Or the alkanol ammonium ion and
（ⅳ）CxHy;
Wherein x be 1-22 integer and
Y is an integer of 3 to 45;
And wherein each=NH
+With-NH
+ 3Group and hydrogen halides associate, wherein halogenide Cl preferably
-Or Br
-
The preferred example of the hydrohalide derivant of ornithine cycle intermediate has:
Arginine monohydrochloride (10)
Dlornithine hydrochloride (11)
The preferred examples of the alkali metal salt derivant of ornithine cycle intermediate has:
Arginine sodium (12)
L-Arginine phosphate., sodium salt (13)
Argininosuccinic acid sodium (14)
Argininosuccinic acid potassium (15)
The preferred examples of the dipeptidase derivant of ornithine cycle intermediate has following dipeptides and corresponding suitable hydrohalide or salt:
L-α-alanyl arginine monohydrochloride (15)
L-cystyl ornithine (16)
L-methionyl citrulline (17)
L-arginyl arginine (18)
L-ornithyl citrulline (19)
L-glutaminate acyl arginine (20)
L-glutaminate acyl citrulline (21)
L-tyrosyl arginine (22)
L-arginyl methionine (23)
L-ornithyl methionine (24)
L-melon aminoacyl methionine (25)
L-arginyl aspartic acid (26)
L-arginyl glutamic acid (27)
L-arginyl leucine acetate (28)
L-arginyl lysine acetate (29)
L-arginyl phenylalanine acetate (30)
L-ornithyl aspartic acid (31)
The preferred examples of other derivant of ornithine cycle intermediate has:
Methylarginine dihydrochloride (32)
Arginine ethyl ester dihydrochloride (33)
Ethyl citrulline (34)
N-pro-pyl ornithine (35)
N-octyl arginine (36)
N-octyl citrulline (37)
N-octyl ornithine (38)
Compositions can comprise two or more ornithine cycle intermediate or derivatives thereofs thus defined.
When selected ornithine cycle intermediate is citrulline or its derivant, preferably also comprise aspartic acid in the present composition, this is because citrulline and aspartic acid in conjunction with generating argininosuccinic acid, show as Fig. 1.
Equally, when selected ornithine cycle intermediate was ornithine or its derivant, the present composition comprised that carbamyl phosphate is favourable, generated citrulline because of carbamyl phosphate can promote ornithine, and this also can see from Fig. 1.
The ornithine cycle intermediate that contains in the present composition or the total amount of their derivant are for being enough to keep or increase the amount of hair growth.This content will depend on the effectiveness of intermediate.Some intermediate can be than other more effective, but general content is the 0.001-99% of said composition weight, is generally 0.01-30%, this content will be provided for the suitable concentration on skin, the particularly scalp.Repetitive administration as required is to promote hair growth.
Acceptable excipient on the cosmetics
The present composition comprises that also cosmetics and/or physiology go up acceptable solid, semisolid or liquid excipient, so that make ornithine cycle intermediate or their derivant be applied to skin with suitable dilution factor.The character of excipient depends on the method for selected compositions topical.Excipient itself can be inert or itself have physiology or the benefit of pharmacology aspect.
For this reason, the scope of the probability of the selection of excipient is very wide, and this depends on the product form of the compositions of needs.Suitable excipient will be classified in the narration afterwards.
Should be noted that excipient is the material that can be used as diluent, dispersant or the solvent of ornithine cycle intermediate or their derivant, therefore can guarantee that the concentration that they can be suitable is applied to equably or is distributed on hair and/or the scalp.The preferably the sort of ester that can help of excipient infiltrates the material of skin with the direct environment of arrival hair follicle.The present composition can comprise water as excipient, and/or acceptable non-water excipient at least a cosmetics.
Non-water excipient can comprise the liquid or solid lubricant, solvent, wetting agent, thickening agent or powder.The excipient of these types can use separately separately or use as the mixture of one or more excipient, and example separately is as follows:
Lubricant, as octadecanol, single ricinoleic acid glyceride, ermine oil, hexadecanol, isostearic acid isopropyl ester, stearic acid, Palmic acid isobutyl ester, stearic iso-16 alkyl esters, oleyl alcohol, isopropyl laurate, lauric acid hexyl ester, decyl oleate, octadecane-2-alcohol, different hexadecanol, eicosanol, docosanol, Palmic acid one or six esters, silicone oil such as dimethyl polysiloxane, n-butyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, butyl stearate, Polyethylene Glycol, 2,2'-ethylenedioxybis(ethanol)., lanoline, cocoa butter, Semen Maydis oil, Oleum Gossypii semen, olive oil, palm-kernel oil, rapeseed oil, safflower oil, Efamast (evening primrose oil) Oleum Glycines, Oleum Helianthi, American Avocado Tree oil, Oleum sesami, Oleum Cocois, Oleum Arachidis hypogaeae semen, Oleum Ricini, acetyl lanolin alcohol, vaseline, mineral oil, butyl myristate, isostearic acid, Palmic acid, linoleic acid isopropyl ester, Lauryl lactate, Tetradecyl lactate, decyl oleate, myristyl myristate;
Propellant, as propane, butane, iso-butane, dimethyl ether, carbon dioxide, nitrous oxide; Solvent, as ethanol, dichloromethane, isopropyl alcohol, acetone, ethylene glycol monoethyl ether, DEGMBE, carbitol, dimethyl sulfoxine, dimethyl formamide, oxolane; Powder, as Chalk, Talcum, bleaching earth, Kaolin, starch, natural gum, colloidal state sodium polyacrylate Silicon stone (colloidal silica sodium polyacrylate), tetraalkyl and/or trialkyl aryl terre verte, the Magnesiumaluminumsilicate of chemical modification, organically-modified montorillonite clay, aluminium hydrosilicate, fuming Silicon stone (fumed silica) carboxyl ethylene polymer, sodium carboxymethyl cellulose, ethylene glycol monostearate, glycol distearate.
Acceptable excipient is generally the 10-99.999% of Emulsion weight on the cosmetics, is good with 10-99%, is best with 50-99%, and is not having under other cosmetics additives situation, but its balanced combination thing.
Active reinforcing agent
The present composition also can contain active reinforcing agent.
Active reinforcing agent can be selected from the multiple molecule that can play a role aspect different, to strengthen the hair growth effectiveness of ornithine cycle intermediate.The specific kind of active reinforcing agent comprises (a) other hair growth stimulant, (b) penetration enhancers and (c) cationic polymer; Their existence can further improve ester and pass the transhipment that horny layer arrives the site of action of hair follicle direct environment.
Some active reinforcing agents also can play the effect of excipient to ester.
(a) other hair growth promoting stimulant
ⅰ. the example that itself can stimulate or strengthen other material of hair growth comprises, as Benasept, Benzene Chloride ethoxy ammonium, phenol, estradiol, hydrochloric acid biphenyl azanol, maleic acid chlorpheniramine, CHLOROPHYLLINE derivant, cholesterol, salicylic acid, cystine, methionine, capsicum tincture, benzyl nicotinate, dl-menthol, Oleum menthae, calcium pantothenate, panthenol, Oleum Ricini, hinokitiol, andrographolide, resorcinol;
Other material that itself can increase the terminal hair growth rate comprises:
The disaccharidase of ⅱ (a) α-1,4 esterification is seen EP-A0064012, Choay S.A. and
The oligosaccharide of ⅱ (b) esterification is seen EP-A 0211610, Uniever;
ⅲ. the Minoxidil glucuronide, see EF 0242967, Unilever;
ⅳ. Minoxidil sulfate, see WO 86/04231, Upjohn company;
ⅴ. Minoxidil and its other derivant, see US 4139619/Upjohn company;
ⅵ. ethylenediaminetetraacetic acid or its salt, see US 4814351, Redken Laboratories, Inc.;
ⅶ. direct proteoglycan enzyme inhibitor, as 1, the 10-phenanthroline, EP 0277428, Unilever;
ⅷ glycosaminoglycans enzyme (Glysaminoglycanase) inhibitor, as D-glucose-1, the 4-lactone is seen EP 0277428, Unilever;
ⅸ. the glycosaminoglycans enzyme inhibitor, as N-acetyl-glucosamine, see EP 0277428, Unilever;
ⅹ. glycosaminoglycans chain cell absorption inhibitor, as hexuronic acid and its ester, see EP 0277428, Unilever;
ⅹ ⅰ. the chemical inhibitor of glycosidase activity, be selected from lactams, as D-glucose-1, the 5-lactams is seen EP 0334586, Unilever;
ⅹ ⅱ. the chemical agonist of Protein kinase C enzyme, be selected from DG, as 1,2-two oleoyls-sn-glycerol are seen EP 0334585, Unilever;
ⅹ ⅲ. the glycosaminoglycans enzyme inhibitor, as 6-methyl-glucose-1, the 4-lactone is seen EP 0348184, Unilever;
ⅹ ⅳ. the glycosaminoglycans enzyme inhibitor, be selected from the monosaccharide of acidylate, as 2-propionamido--2-deoxyglucose, see EP 0348184, Unilever;
ⅹ ⅴ. the ester of pyroglutamic acid, as just own ester of pyroglutamic acid and pyroglutamic acid n-octyl, see US 4774255, lever brother company;
ⅹ ⅵ. the saccharinic acid of saccharinic acid or acidylate, or its salt or ester, as glucosaccharic acid and its disodium salt, see EP 378388, Unilever;
ⅹ ⅶ. the ethylene that aryl replaces, as 1,1-dicarboxyl-2-(4-hydroxy phenyl) ethylene, see EP 403238, Unilever.
(b) penetration enhancers
As previously mentioned, the existence of penetration enhancers improves ornithine cycle intermediate and its transhipment of derivant from horny layer to the hair follicle site of action, thereby can strengthen the effect of ornithine cycle intermediate and derivant thereof.
Therefore, penetration enhancers can work in many-side.For example, it can improve the ornithine cycle intermediate the distribution of skin surface or, when used the part, it can increase the distribution that is entered into skin by compositions, therefore, helped to make compositions to arrive site of action.Also has other mechanism that strengthens hair growth promoter usefulness.
The example of penetration enhancers comprises:
2-methyl propan-2-ol, propan-2-ol, 2 hydroxy propanoic acid ethyl ester, oneself-2,5-glycol, POE(2) ether, two (2-hydroxypropyl) ether, penta-2, the 4-glycol, acetone, POE(2) methyl ether, 2 hydroxy propanoic acid, the 2-Hydroxycaprylic acid, 1-propanol, 1, the 4-oxane, oxolane, fourth-1, the 4-glycol, propylene glycol ester in two ninth of the ten Heavenly Stems, polyoxypropylene 15 stearyl ether, capryl alcohol, the POE ester of oleyl alcohol, oleyl alcohol, lauryl alcohol, dioctyl adipate, didecyl adipate (Dicapryl adipate), diisopropyl adipate, Dermol DIPS, dibutyl sebacate, ethyl sebacate, dimethyl sebacate, di-n-octyl sebacate, the suberic acid dibutyl ester, dioctyl azelate, dibenzyl sebacate, dibutyl phthalate, dibutyl azelate, ethyl myristate, dimethyl azelate, butyl myristate, dibutyl succinate, didecyl phthalate, decyl oleate, ethyl hexanoate, ethyl salicylate, isopropyl palmitate, ethyl laurate, n-nonanoic acid 2-ethyl-own ester, isostearic acid isopropyl ester, butyl laurate, benzyl benzoate, butyl benzoate, lauric acid hexyl ester, ethyl caprate, ethyl caprilate, butyl stearate, benzyl salicylate, 2 hydroxy propanoic acid, the 2-Hydroxycaprylic acid, dimethyl sulfoxine, N,N-dimethylacetamide, N, dinethylformamide, 2-Pyrrolidone, 1-Methyl-2-Pyrrolidone, the 5-N-methyl-2-2-pyrrolidone N-, 1,5-dimethyl-2-Pyrrolidone, 1-ethyl-2-pyrrolidone, phosphine oxide, sugar ester, tetrahydrofurfuryl alcohol (Tetrahydrofufural alcohol), carbamide, toluamide and 1-dodecyl-aza-cycloheptane-2-ketone between diethyl.
(c) cationic polymer
As previously mentioned, the existence of cationic polymer can improve the transhipment to hair and scalp of ornithine cycle intermediate or its derivant, thereby has strengthened their effectiveness.The example of preferred cation polymer has:
Guar Hydroxypropyltimonium chloride, quaternary salt (Quaternium)-19, quaternary salt-23, quaternary salt-40, quaternary salt-57, poly-(chlorination dipropyl diallyl ammonium), Poly(methyl-r-propaniodiallylammonium chloride), poly-(pyridine of chlorination diallyl base), poly-(ethlyene dichloride yl pyridines), quaternised poly-(vinyl alcohol), quaternised poly-(methacrylate dimethylamino ethyl ester); And composition thereof.
According to the present invention, the consumption of active reinforcing agent by the weight of compositions, generally is 0.1-50%, is good with 0.5-25%, and 0.5-10% can be better.
Optional material and cosmetics additive to skin beneficiating
The form of present composition most convenient is an Emulsion.In this case, generally can contain oil or oily matter, it can make water-in-oil type or oil-in-water emulsion together with emulsifying agent, and this depends primarily on the hydrophile-lipophile balance value (HLB) of used emulsifying agent.
Oil or oily matter
The present composition can contain one or more oil or butyrous other material is arranged.
The example of suitable oil has: mineral oil and vegetable oil, and oily matter, and as those materials of in lubricant, having listed.Other oil or oily matter comprise silicone oil, and volatility and nonvolatile is as polydimethylsiloxane.
Oil or oily matter, when being used to form Emulsion, by the stereometer of compositions, general consumption is at most 90%, preferably 10 to 80%.
Emulsifying agent
The present composition also can contain one or more emulsifying agents, and its selection depends on that generally the Emulsion of generation is water-in-oil type or oil-in-water type.
When the needs water-in-oil emulsion, selected a kind of emulsifying agent or numerous emulsifiers, its HLB meansigma methods generally is 1-6.When the needs oil-in-water emulsion, selected a kind of emulsifying agent or numerous emulsifiers, its HLB meansigma methods should be greater than 6.
The example of suitable emulsifying agent is listed in following table 1, has provided the chemical name of emulsifying agent and the trade name on the market simultaneously, and the HLB meansigma methods.
Table 1
The chemical name trade name HLB value of emulsifying agent
Sorbitan trioleate Arlacel 85 1.8
Arlacel-65 Span 65 2.1
Glyceryl monooleate Aldo MD 2.7
Glyceryl monostearate Atmul 84S 2.8
Glyceryl monolaurate Aldo MC 3.3
Arlacel-83 Arlacel 83 3.7
Arlacel-80 Arlacel 80 4.3
Arlacel-60 Span 60 4.7
Polyoxyethylene (2) stearyl ether Brij 72 4.9
Polyoxyethylene sorbitol Cera Flava derivant G-1702 5
Macrogol 200 dilaurate Emerest 2,622 6.3
Arlacel-40 Arlacel 40 6.7
Polyoxyethylene (3.5) nonyl phenol Emulgen 903 7.8
Macrogol 200 monostearate Tegester PEG 8.5
200 MS
Arlacel-20 Arlacel 200 8.6
PEG400 dioleate Tegester PEG
400-DO 8.8
Polyoxyethylene (5) monostearate Ethofat 60-16 9.0
Polyoxyethylene (4) anhydro sorbitol list Tween 61 9.6
Stearate
Polyoxyethylene (4) Laurel ether Brij 30 9.7
Polyoxyethylene (5) dehydration Pyrusussuriensis Tween 81 10.0
The alcohol monoleate
Liquid Macrogol monoleate Neutronyx 834 10.4
Polyoxyethylene (20) anhydro sorbitol Tween 65 10.5
Tristearate
Polyoxyethylene (20) anhydro sorbitol Tween 85 11.0
Trioleate
Polyoxyethylene (8) monostearate Myrj 45 11.1
PEG400 monoleate Emerest 2,646 11.7
PEG400 monostearate Tegester PEG 400 11.9
Polyoxyethylene (10) monoleate Ethofat 0,/20 12.2
Polyoxyethylene (10) stearyl ether Brij 76 12.4
Polyoxyethylene (10) margaron Brij 56 12.9
Polyoxyethylene (9.3) octyl phenol Triton X-100 13.0
Polyoxyethylene (4) anhydro sorbitol list Tween 21 13.3
Monolaurate
Macrogol 600 monoleate Emerest 2,660 13.7
Cetomacrogol 1000 dilaurate Kessco 13.9
Polyoxyethylene sorbitol lanolin derivative G-1441 14.0
Polyoxyethylene (12) Laurel ether Ethosperse LA-12 14.4
Polyethylene glycol 1500 dioleate Pegosperse 1,500 14.6
Polyoxyethylene (14) laurate Arosurf HFL-714 14.8
Polyoxyethylene (20) anhydro sorbitol list Tween 60 14.9
Stearate
Polyoxyethylene (20) anhydro sorbitol Tween 80 15.0
Monoleate
Polyoxyethylene (20) stearate Myrj 49 15.0
Polyoxyethylene (20) stearyl ether Brij 78 15.3
Polyoxyethylene (20) anhydro sorbitol Tween 40 15.6
Monopalmitate
Polyoxyethylene (20) margaron Brij 58 15.7
Polyoxyethylene (25) propylene oxide list G-2162 16.0
Stearate
Polyoxyethylene (20) sorbitol list Tween 20 16.7
Laurate
Polyoxyethylene (23) Laurel ether Brij 35 16.9
Polyoxyethylene (50) monostearate Myrj 53 17.9
Macrogol 4000 monostearate Pegosperse 4,000 18.7
MS
Above listed emulsifying agent is not in order to limit, and just enumerates the selectable emulsifying agent that some suitable the present invention use.
Be appreciated that if necessary, can use two or more emulsifying agents.
Adding the amount of emulsifying agent or its mixture in the present composition, by the weight of compositions, be advisable with 1-50%, is good with 2-20%, and is best with 2-10%.
Water
The present composition also can contain water, and is general maximum moisture 90% by volume, preferably 5-80%.Water can play the effect of acceptable excipient on the cosmetics.
Silicone surfactant
The present composition also can comprise high-molecular weight silicone surfactant, and it also can play emulsifying agent, can replace or join in above-mentioned any emulsifying agent.
Silicone surfactant is the dimethylpolysiloxanepolymer polymer that has polyoxyethylene and/or polyoxypropylene side chain of high molecular (10000 to 50000).
Dimethylpolysiloxanepolymer polymer easily with the dispersion form in volatile siloxane for using.Described dispersion contains: 1-20%(volume for example) this polymer and 80-99%(volume) volatile siloxane.In theory, this dispersion contains the 10%(volume) be dispersed in the polymer in the volatile siloxane.
Can disperse the example of the volatile siloxane of polysiloxane polymer that polydimethylsiloxane (pentamer and/or six aggressiveness) is arranged.
Particularly preferred silicone surfactant is SILIBIONE OIL 70047 V20 DC-21330 DC21330 (cyclomechicone) and dimethicone copolyol, as the DC 3225C Formulation Aid that obtains from DOW CORNING.Other has lauryl first polysiloxanes copolyol such as DC Q2-5200 also can obtain from Dow Corning.
The content of silicone surfactant in the compositions, general maximum by the weight of Emulsion to 25%, 0.5-15% preferably.
Surfactant
The compositions of Shi Yonging can be mixed with shampoo in the methods of the invention, and therefore, it comprises on one or more cosmetics acceptable and be suitable for being locally applied to surfactant on the hair.The example of suitable shampoo surfactant sees below.Contain 4%(by weight when compositions is mixed with) or when being higher than 4% surfactant, can prove that the ideal concentration of using the metabolism intermediate surpasses 5%(weight), may be greater than 8%(weight).Even can prove that surfactant concentrations is lower, as 1%(weight) or be higher than 1% o'clock the most desirable.
Cationic surfactant
The present composition can contain cationic surfactant, preferably is selected from alkyl sulfate, alkyl ether sulfate; alkylsulfonate, alkylaryl sulfonates, ethylenic sulfonate; acyl sarcosinates, acyl group taurine (acyl tauride), acyl isethinate; the non-alkyl ester salt of 2-Sulfosuccinic acid; dialkyl sulfosuccinate salt, acyl-lactate, the a-amino acid of acidylate; the alkyl carboxylate, phosphoric acid one Arrcostab and phosphate dialkyl ester.
The instantiation of cationic surfactant comprises:
Alkyl sulfate, [EMPICOL CX for example can be from Albright ﹠amp as sodium lauryl sulfate; Wilson buys), and triethanolamine lauryl sulfate [EMPICOL TL40/T for example can be from Albright ﹠amp; Wilson buys];
Alkyl ether sulfate, [EMPICOL ESB70 for example can be from Albright ﹠amp as Sodium Lauryl Ether Sulphate; Wilson buys];
Alkylsulfonate is as alkyl (C
13-C
18) sodium sulfonate [for example HOSTAPUR SAS30 can buy from Hoechst];
Alkylaryl sulfonates is as sodium alkyl benzene sulfonate [for example TEEPOL CM44 can buy from Shell];
Ethylenic sulfonate is as olefinic sulfonic acid (C
5-18) sodium [for example HOSTAPUR OS can buy from Hoechst];
Acyl sarcosinates, the structure of signing an undertaking (51):
R wherein
3Be selected from C
6-14Alkyl and
M is an opposite ion, is selected from alkali metal, and the ammonium of ammonium and replacement such as alkanol ammonium, an example of the acyl sarcosinates of the structure of signing an undertaking (51) are sodium lauryl sarcosinate [for example HAMPOSYL L-95 can buy from Grace];
The acyl group taurine, the structure of signing an undertaking (52):
R wherein
4Be selected from C
8-18Alkyl,
The example of acyl group taurine of structure (52) of signing an undertaking is Cortex cocois radicis N-methyltaurine (coconutmethyl taurine) [for example FENOPEN TC 42, can buy from GAF];
Acyl isethinate, the structure of signing an undertaking (53):
R wherein
5Be selected from C
8-18Alkyl,
The example of acyl isethinate of structure (53) of signing an undertaking is hydroxyethyl acyl sodium sulfonate [for example JORDAPON Cl can buy from Jordon];
2-Sulfosuccinic acid: an alkyl ester salt, the structure of signing an undertaking (54):
R wherein
6Be selected from C
10-20Alkyl,
The example of 2-Sulfosuccinic acid-alkyl ester salt of structure (54) of signing an undertaking comprising:
[EMPICOL SLL for example can be from Albright ﹠amp for 2-Sulfosuccinic acid lauryl sodium; Wilson buys],
Sulfosuccinic acid alkyl ester magnesium [for example ELFANOL 616 Mg can buy from AKZO],
[EMPICOL SDD for example can be from Albright ﹠amp for ethyoxyl 2-Sulfosuccinic acid lauryl sodium; Wilson buys],
Cortex cocois radicis single ethanol amide ethoxy sulfosuccinate (coconut monoethanolamide ethoxysulphosuccinate) [for example EMPICOL SGG],
Polyglycol ether 2-Sulfosuccinic acid lauryl disodium [for example SURTAGENE S30 can buy from CHEM-Y],
Polyethylene Glycol sulfosuccinate ester salt [for example REWOPOL SBFA30 can buy from REWO];
Dialkyl sulfosuccinate salt, the structure of signing an undertaking (55):
R wherein
7And R
8Identical or different, be selected from C
6-14Alkyl,
The example of dialkyl sulfosuccinate salt of structure (55) of signing an undertaking is 2-Sulfosuccinic acid two lauryl sodium [for example EMCOL 4500, can buy from Witco];
Acyl-lactate, the structure of signing an undertaking (56):
R wherein
9Be selected from C
6-16Alkyl and
N is 1 or 2,
The example of acyl-lactate of structure (56) of signing an undertaking is capryl lactate [is PATIONIC 122a, can be from Patterson, CJ buys];
The acidylate a-amino acid is as sodium lauroyl glutamate [for example ACYLGLUTAMATE LS-11 can buy from Ajinomoto Co.Inc.];
The alkyl carboxylate is as alkyl C
12-14O(EO)
4OCH
2CO
2Na[is AKYPO RLM38 for example, can buy from AKzo];
Phosphoric acid-Arrcostab such as phosphoric acid-lauryl, and phosphate dialkyl ester are as dioctylphosphoric acid ester.
Amphoteric surfactant
Shampoo Compositions of the present invention also comprises amphoteric surfactant.Suitable amphoteric surfactant is the aliphatic quaternary ammonium derivant, phosphorus and sulfonium compound, and altogether middle fat group contains 8-18 carbon atom, and can be straight or branched, and also contain the water-soluble anionic group, as carboxylate radical, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.
Preferred amphoteric surfactant comprises:
Alkyl betaine, the structure of signing an undertaking (57):
R wherein
10Be C
1-16Alkyl, the example of the alkyl betaine of the structure of signing an undertaking (57) are that [EMPIGEN BB for example can be from Albright ﹠amp for the lauryl dimethyl betanin; Wilson buys];
The alkyl amido CAB, the structure of signing an undertaking (58):
The example of alkyl amido CAB of structure (58) of signing an undertaking is cocamidopropyl betanin [for example TEGOBETAIN L7 can buy from Goldschmidt];
The structure of alkyl both sexes glycinate or alkyl both sexes propionate is as (59):
R wherein
11Be selected from H, CH
2COO
-(CH
2)
2COO
-And
R
12Be selected from CH
2COO
-(CH
2)
2COO
-
The suitable example of chemical compound (59) is Cortex cocois radicis both sexes glycinate (cocoamphoglycinate) (buying from GAF) and Cortex cocois radicis both sexes propionate.
Sultaines, the structure of signing an undertaking (60):
R wherein
13Be selected from C
12-16Alkyl-alkyl acylamino-group,
The example of sultaine of structure (60) of signing an undertaking is for example CYCLOTERIC BET-CS of cocamidopropylhydroxysultaine[, can buy from Alcolac].
Best amphoteric surfactant is lauryl dimethyl betanin and cocamidopropyl betanin.
These amphoteric surfactantes help shampoo of the present invention to spume, and have improved the puckery firmly of anion surfactant simultaneously.
Non-ionic surface active agent
It is 8 or greater than 8 alkoxylate or glycosidic non-ionic surface active agent that shampoo Compositions of the present invention also can contain the HLB value, mix with other surfactant within the scope of above definition greater than the non-ionic surface active agent of this value, form clarifying isotropic solution usually.Preferred nonionic is polyxyethylated ester and polyoxyethylene alkyl ether and alkylpolyglycosides.
The example that polyxyethylated ester is suitable is the tween 80 of tool CTFA standard, and it is the oleate of sorbitol and sorbitol anhydride and the mixture that about 20 moles ethylene oxide condensation forms.Suitable in addition is tween 20, and it is the mixture that is formed by laurate or sorbitol and sorbitol anhydride and about 20 moles of ethylene oxide condensations.
Tween 80 and tween 20 can be buied from ICI Americas, and trade name is respectively TWEEN80 and TWEEN20.
That also be applicable to the present composition is C
9-11The polyglycol ether of alcohol, it on average has 8 ethoxy units, is commercially available, as NONIDET LE-8T or SYNPERONIC 91-8T, and C
12-15The polyglycol ether of alcohol, it on average has 9 ethoxy units, is commercially available, as DOBANOL 25-9.
The most useful alkylpolyglycosides comprises the glycosides of glucose or glucose oligomer, and its alkyl chain can be C
8-16, the average of glucose unit is 1 to 2.Suitable example is ORAMIX NS10, and it is C
10-12The aliphatic alcohol glycosides, 1.5 glucose units of on average having an appointment.
The content of surfactant in the present composition with composition weight meter, reaches 30% most, preferably 1-20%.
Other cosmetics additive
The example of disposable conventional additives comprises antioxidant, as butylated hydroxytoluene; Sunscreen such as octyl methoxycinnamate and butyl methoxydibenzoylmethise; Film former is as the poly-methyl isopropyl ether of perfluoro; Wetting agent, as glycerol, sorbitol, 2-Pyrrolidone-5-carboxylate, dibutyl phthalate, gelatin, Polyethylene Glycol is as PEG200-600; Buffer agent, the buffer agent that forms with alkali such as triethanolamine or sodium hydroxide as lactic acid; Wax, as Cera Flava, ceresine, paraffin; Plant extract, as Aloe, Centaurea cyanus, witch hazel, Fols sambuci williamsii, Fructus Cucumidis sativi; Thickening agent; Active reinforcing agent; The color element; And spice.But cosmetics additive balance said composition.
Compositions anticorrosion
The present composition can be anticorrosion by a kind of like this mode,, before making the production back and selling and use can be arranged a persistent storage period that is.In theory, compositions has indefinite storage period.
Therefore, be apparent that the ornithine cycle intermediate may be easy to be subjected to the influence of antibacterial, mycete and fungus and other microorganism, particularly when PH was near skin, this also was the characteristics of preferred compositions.Make compositions anticorrosion unless take measures, otherwise because the biodegradation of precursor, the storage period of compositions can unacceptable weak point.
In order to preserve, this compositions does not preferably have or does not have basically the microorgranic contaminant that can survive, these pollutant can make compositions be subjected to the destruction of microorganism and/or the biodegradation of the precursor before the compositions part is used for mammal skin or hair.Yet, be understandable that, the compositions that the present invention also relates to define here, it may contain the microorganism that can survive but hide, and as bacterial spore, but prerequisite is before using compositions, can not cause the breeding of microorganism basically under the antiseptical condition.
The example that can be used for compositions is carried out preserving method comprises as follows:
(ⅰ) sterilization
The present composition can come anticorrosion with the microbial impurities of removing or killing all survivals basically through sterilization.This can realize that for example the gamma-rays with lethal dose carries out irradiation, heat sterilization or UV filters by the technology of using pharmaceuticals industry to possess.
(ⅱ) chemical preservative
The present composition also can be anticorrosion by adding chemical preservative therein.The effect of antiseptic is can stop antibacterial, mycete or other growth of microorganism or kill them.
The example of chemical preservative comprises ethanol, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methyl ester, ethyl ester, propyl ester and the butyl ester of sodium propionate and right-hydroxy benzoic acid.The amount of the chemical preservative that can add in the present composition generally is 0.05-5%, preferably 0.1-2%(weight).Selected consumption will be enough to suppress the breeding of microorganism.
(ⅲ) water activity inhibitor
The present composition also can come anticorrosion by adding the entry activity inhibitor therein.Described water activity inhibitor comprises for example glycerol, propylene glycol, sorbitol, sugar and salt, for example alkali halide, sulfate and carboxylate.When the water activity inhibitor, to add q.s in the present composition to reduce water activity (a
w) to 1-＜0.9,＜0.85 is good, and＜0.8 better.When its minimum, yeast, mycete and fungus can not breed.
Product form and packing
When the present composition is used for the treatment of skin and/or hair when the part, can be mixed with shampoo or hair care agent, perhaps be liquid or gel form, or viscosity is the lotion of 4000-10000mPas, viscosity is liquid milk unguentum or the ointment of 10000-20000mPas, viscosity is 20000-100000mPas, or more than.
Compositions can be contained in the container with suitable it viscosity and be convenient to the consumer plan and use.For example, shampoo, the hair care agent, liquid, gel, lotion or liquid milk unguentum can be contained in bottle or sachet or the aerosol device of propellant actuated is arranged or be equipped with in the container that is suitable for the pump of finger manipulation.When compositions was emulsifiable paste, it can simply be contained in an on-deformable bottle or squeeze-type container such as flexible pipe or have in the wide mouthed bottle of lid.
The container that therefore the present invention also provides a sealing wherein is equipped with acceptable composition on the cosmetics as defined herein.
Preparation method
The present invention also provides the preparation method of hair growth composition, it comprise with the ornithine cycle intermediate (as herein defined) of effective dose with mix for acceptable carrier on the cosmetics of this intermediate.
The purposes of ornithine cycle intermediate in increase or maintenance hair growth
Therefore the present invention also provides ornithine cycle intermediate (as herein defined) to be locally applied on mammal skin or the hair to increase or to keep the purposes of hair growth.
The present composition mainly is the scalp that is locally applied to the people, particularly or bald head, so that make fine, soft fur that the long terminal hair that becomes take place, or increases the rate of growth of terminal hair.Said composition is being applied on hair and the scalp to reduce or to prevent baldly of preventability also, guarantees that hair grows under the state of health, reduces common alopecia simultaneously.
Consumption and frequency that compositions is applied on hair and/or the scalp can change in very wide scope, will be according to a human needs, but the example of suggestion is: the local consumption that contains the selected ornithine cycle intermediate of 0.00001-1 gram is 0.1-5 gram every day, administration time is at least six months, in most of the cases, can improve the growth of hair.
Test the effect of estimating the ornithine cycle intermediate with external hair follicle growth
Chemical compound is estimated the available experiment in vitro of the effect of hair growth, and it is to be undertaken by the rate of increase of measuring the people's hair follicle that exsomatizes in the culture fluid.
Hair follicle is from the separation of skin
This experiment comprises by micromanipulative technique will have the hair follicle that do not decrease ball top from application on human skin isolating important step on the skin of finishing for example.Method therefor is seen Philpott etc., J.Cell Sci 97,463, (1990).
Therefore, hair follicle isolating committed step from the subcutaneus adipose tissue at its place that will have intact ball top comprises: from the hair shaft that a bit cuts off folliculus below the epidermis, so that ball top is intact, and still have the part hair shaft.
The hair shaft of folliculus is preferably in skin-subcutaneous fat and cuts off at the interface.
When cutting apart hair shaft with this method, available any suitable cutting instrument, but the most handy keratome or dissecting knife.
Then by the ball top that is attached with the hair shaft nubbin being separated from skin from usually mechanically separating hair around the loose subcutaneous fat that adheres to of ball top.This normally on the corium of skin or upper strata separated and remove after carry out, it is damaged when avoiding dialling ball top.
Like this, ball top and the hair shaft nubbin that adheres to do not have damage, function fully, be transferred in the culture medium under the state of survival.
The cultivation of stripped hair follicle
To transfer in the proper culture medium by the isolating hair follicle of above-mentioned technology, carry out to influence the experiment of the material of these hair follicle future developments then.
The method of introducing provides a preferable methods that hair growth promoting is cultivated and tested now.
According to preferred cultural method, the stripped hair follicle that will obtain from the skin of finishing is kept at the 1ml Williams E culture medium, wherein add L-glutaminate (2mM), insulin (10 μ g/ml), hydrocortisone (10ng/ml) and antibiotic add or do not add experiment hair growth promoting material (ornithine cycle intermediate).To cultivate based on 37 ℃, 5% CO
2Under+95% air atmosphere, in each hole of 24 porous discs (Corning), cultivate, can measure the length of single hair follicle so meticulously.
Williams E culture medium can find under the breadboard catalogue of FLOW 12-502 item.The prescription of Williams E culture medium is seen Williams GM. etc., Experimental Cell Research, 69(1971) 106 pages.
Rate of growth every day of each folliculus is calculated by the length variations of measuring folliculus every day with the accumulation growth, and it has used the microscope of being furnished with eyepiece micrometer, calculates the meansigma methods of all folliculus thus.
Evaluation of result
Therefore, the hair follicle that exsomatizes can be estimated by the increase of measuring length the reaction of experiment material, if any, with the experiment material contrast is carried out.
In vitro method described herein be used to estimate three ornithine cycle intermediate, be arginine monohydrochloride, the effect of dlornithine hydrochloride and citrulline.Experiment is carried out in the presence of glutamine, compares with independent glutamine.Proof ornithine cycle intermediate is better than one glutamine.
The gained result summarizes and to be listed in the table below in 2.
Table 2 note:
1. contrast (not adding the ornithine cycle intermediate).
2. the result is based on modifying the observation of the hair follicle growth of skin to taking from three patient surface.For each treatment, each patient's folliculus all experimentizes by method as herein described.It is the sum of all 18 treatments.
3. the result is based on modifying the observation of the hair follicle growth of skin to taking from five patient surface.For each treatment, each patient's folliculus all experimentizes by method as herein described.Be 57 treatment and 54 sums that the culture medium of adding citrulline is treated to control medium (independent glutamine).
4. not remarkable.Get by seven experimental calculation according to the student.
The result who is summarised in table 2 shows: compare with single glutamine (contrast), in the presence of glutamine (as hair growth promoting rate promoter), each ornithine cycle intermediate all can make hair growth significantly increase.This confirms the middle physical ability promotion of ornithine cycle or can keep hair growth at least.
In similar experiment, compare and be added with the arginic WilliamsE culture medium of 1mM with the WiliamsE culture medium and make the experiment culture medium, can find: the percentage rate of taking from three different patients' folliculus hair growth increase has some variations.With comparing of same patient, the percentage rate that hair growth increases is 7%, 3.5% and 6%.Hair growth on average increases by 5.5%, obviously is significant statistically.
Carry out same experiment with the Williams E culture medium that is added with 1mM ornithine and 1mM citrulline.The result who is obtained by each patient's folliculus has significance,statistical, to citrulline average out to 7.4%, to ornithine average out to 6.4%.
Used the similar cultural method of stripped folliculus for the synthetic experimental technique of gross protein.Folliculus was cultivated two days in the Williams E culture medium that arginine lacks, need be added arginine so that contain 0.281mM, the arginine of 0.574mM or 1.435mM,
14The leucine of C labelling and exist with the arginine of preceding same concentrations and to continue down to cultivate three hours.
After the cultivation, from the culture medium of radioactivity, remove folliculus, wash with being added with the unmarked leucic PBS 3 * 1ml of 10mM, bonded to replace non-covalent bond
14The C-leucine.Then at the ice-cold 0.1M K of 1ml
2EDTA(PH12.3) in, in manual glass/glass homogenizer with its homogenize.Homogenate was placed 30 minutes at 4 ℃, to discharge and solubilising protein.The centrifugal cell debris of removing is separated the 110 μ l supernatant samples obtain are carried out gross protein with biology-radiometric analysis [according to Bradford, Anal.Biochem., 72,248(1976)] mensuration.For ease of preserving, add the ice-cold 15%TCA of 0.5ml in the supernatant, place 15 minutes to be settled out protein at 4 ℃.Collecting precipitation, with 15%TCA 4 * 5ml washing, vacuum filtration is to Whatman GF/C(2.4 centimetre) filter paper on, this filter paper washed with being added with the unmarked leucic PBS of 10mM in advance.Final drying filter paper, its radioactivity can be measured with liquid scintillation spectrometry.Cell debris is dissolved among the 0.5ml Soluene, and calculates its radioactivity, show: the bonded radioactivity less than 15% is discarded in the cell debris powder.
The result is:
The picked-up of arginine concentration leucine
(mM) (pmol/ hour/folliculus)
0.287 80
0.574 93
1.435 110
This shows: arginine increases protein synthesis in hair follicle.
Embodiment
The present invention illustrates with following embodiment.Each embodiment provides a compositions, and it contains the metabolism intermediate and the derivant thereof of one or more ornithine cycles of the present invention specifically.Xuan Ding metabolism intermediate is represented by the structure sequence number of listing in the past in this manual.
Embodiment 1
Present embodiment illustrates lotion of the present invention, and this lotion is fit to the part and is used for increasing on the skin hair growth.
Lotion formulation is as follows:
The % w/w
Intermediate (10) 1
Ethanol 99
Spice is an amount of
Embodiment 2
The explanation of this implementation example is suitable for being used in the hair tonic on hair or the scalp.
The hair tonic has following prescription:
The % w/w
Intermediate (11) 2
Ethanol 49
Water 49
Spice is an amount of
Embodiment 3
Present embodiment also illustrates and is fit to the part and is used for lotion on the scalp.
Lotion formulation is as follows:
The % w/w
Intermediate (12) 3
Propan-2-ol 10
Ethanol 87
Spice is an amount of
Embodiment 4
Present embodiment also illustrates the hair tonic that is suitable on hair or the scalp.
The prescription of hair tonic is as follows:
The % w/w
Intermediate (13) 3
Ethanol 40
Water 57
Spice is an amount of
Embodiment 5-8
The washing liquid that following prescription provides can local be used for the treatment of bald or just at bald sex head.
The % w/w
5 6 7 8
Hydroxyethyl-cellulose 0.4-0.4-
Dehydrated alcohol 25 25 25 25
The third-1,2-glycol--38.4 38.4
Fourth-1,3-glycol 38.4 38.8--
P-methylbenzoic acid ester 0.2 0.2 0.2 0.2
Intermediate (14) 5---
Intermediate (15)-4--
Intermediate (16)--3-
Citrulline---4
N-acetyl proline 0.6 0.6 0.6 0.6
Spice 1111
Water adds to 100 100 100 100
Embodiment 9-12
The ointment that following prescription is listed can be used for treating bald.
The % w/w
9 10 11 12
Hexadecanol polyoxyethylene (10) 4444
Hexadecanol 4444
Mineral oil 4 2--
Paraffin-2 4-
Intermediate (17)---4
Intermediate (18) 2---
Intermediate (19)-2--
Intermediate (20)--2-
Minoxidil 0.5 0.5 0.5 0.5
Triethanolamine 0.75 0.75 0.75 0.75
Fourth-1,3-glycol 3333
Synthesising biological polymeric gel 0.3 0.3 0.3 0.3
Antiseptic 0.4 0.4 0.4 0.4
Spice is an amount of
Water adds to 100 100 100 100
Embodiment 13
According to the present invention, present embodiment illustrates the high inner phase Emulsion of the Water-In-Oil that contains intermediate of the present invention.
This Emulsion is by the 10%(volume) oil phase and 90%(weight) water forms.
Oil phase and water are made up of following: %/w/w
Oil phase
Arlacel-80 20
Quaternary salt-18 hectorite 5
Liquid paraffin 75
Water
Intermediate (12) 1
Biosynthesis polymeric gel 1
Antiseptic 0.3
Spice is an amount of
Sodium chloride (1% w/w solution) adds to 100
This emulsifying agent prepares with following method: get 10 parts of (volume) oil phases and it is under agitation slowly added to 90 parts of (volume) aqueous phases.
The high inner phase water-in-oil emulsion of Sheng Chenging can be used on the scalp part like this, to improve hair growth and regrowth.
Following two embodiment 14 and 15 illustrate to can be used for washing hair and send out and scalp and promote the shampoo of natural on-off cycles of hair growth.
Embodiment 14
%/w/w
Sodium laureth sulfate (2 EO) [21% AD] 41.4
Lauryl dimethyl glycine betanin: [30%AD] 4
Coconut fatty acid diethanolamine 1.5
Oil base triethoxy phosphate ester (BRIPHOS 03D) 1
Polyethylene glycol-amine condensation resin (POLYQUART H) [50% activity] 1.5
Antiseptic, pigment, salt 0.58
Intermediate (22) 10
Spice is an amount of
Water adds to 100
Embodiment 15
%/w/w
Sodium laureth sulfate (2 EP) [100% AD] 12
Polymer JR400 2.5
BRIDHOS 03D 2.5
Intermediate (23) 15
Magnesium sulfate 5
Spice is an amount of
Water adds to 100
Embodiment 16
Present embodiment also illustrates and is fit to the part and is used in lotion on the scalp.
This lotion has following prescription:
The % w/w
Intermediate (24) 5
Minoxidil 1
Propan-2-ol 10
Ethanol 84
Embodiment 17
Present embodiment illustrates dust composition of the present invention, and it can be used for scalp in the part.
The % w/w
Converted starch 5
Chemically-modified cellulose-
Boric acid 10
Zinc oxide 5
Intermediate (25) 3
Minoxidil 5
Spice is an amount of
Chalk 10
Pulvis Talci adds to 100
Embodiment 18
Following embodiment illustrates lotion of the present invention, and it can be used on the scalp to prevent alopecia and to stimulate hair restoration the part.
The % w/w
Intermediate (26) 7
Glucose-1,4-lactone 2
Ethanol 16
Citric acid 1.05
Water adds to 100
Regulate PH to 4.2 with sodium hydroxide.
Embodiment 19 and 20
These embodiment illustrate the hair tonic that is suitable on hair and the scalp.
The hair tonic has following prescription:
The % w/w
19 20
Intermediate (27)-2
Intermediate (28) 2-
Glucose-1,5-lactams 33
Ethanol 50 50
Water 45 45
Embodiment 21
Present embodiment illustrates shampoo, and it is fit to the part and is used for hair to clean hair, and it can be discharged into the metabolism intermediate on the scalp to increase hair growth or regeneration simultaneously.
Shampoo has following prescription:
The % w/w
Triethanolamine lauryl sulfate 16.8
Coconut diethanolamide 3.0
Hydroxypropyl emthylcellulose (1) 0.25
Semen Maydis pulp (80% solid) (2) 20.5
Dimethyl polysiloxane (3) 1.0
Cationic cellulose (4) 0.5
Ethanol (SDA 40) 9.0
Vinyl carboxyl polymer (5) 0.75
Intermediate (29) 8
Spice, pigment, antiseptic is an amount of
Water adds to 100
Acid or alkali are regulated PH to 6.5
1.-Methocel E4M（Dow Chemical）
2.-be equivalent to dextrose 42(Staley 1300)
3.-60000 centistoke (Viscasil, GEC)
4.-polymer J R 400
5.-Carbopol 941（BF Goodrich）
Embodiment 22
Present embodiment illustrates shampoo according to the invention.
Shampoo has following prescription:
The % w/w
Sodium laureth sulfate (3 EO) 10
Pearling agent 4
Betanin 2
Cationic polymer 0.2
Intermediate (30) 6.5
Less important composition 4
Water adds to 100
PH value 6-7
Viscosity: 3500-4000cps(Brookfield Spindle No.3, at 10rpm25 ℃).
Embodiment 23
Present embodiment illustrates shampoo according to the invention.
Shampoo has following prescription:
The % w/w
Sodium laureth sulfate [3 EO] (70%AD) 20
Pearling agent 2
Betanin 6
Intermediate (31) 7
Glutamine 1
Siloxane emulsion 1
Cationic polymer 0.1
D-panthenol 0.4
Carbopol 0.4
Sodium chloride 2.5
Less important composition 8.5
Water adds to 100
PH value 6.5
Viscosity: 5000cps(Brookfield Spindle No.3, at 10rpm, 25 ℃)
Embodiment 24
Present embodiment illustrates shampoo according to the invention.
Shampoo has following prescription:
The % w/w
Sodium laureth sulfate [3 EO] (70%AD) 20
Pearling agent 2
Betanin 6
Intermediate (32) 7
Glutamine 1
Siloxane emulsion 1
Cationic polymer 0.1
D-panthenol 0.4
Carbopol 0.4
Sodium chloride 2.5
Less important composition 8.5
Water adds to 100
PH value 6.5
Viscosity: 5000cps(Brookfield Spindle No.3, at 10rpm, 25 ℃)
The following example 25 and 26 illustrates shampoo, and it is used to clean hair and scalp, and can promote the growth of hair.
Embodiment 25
The % w/w
Sodium laureth sulfate (2 EO) [21% AD] 41.4
Lauryl dimethyl glycine betanin: [30%AD] 4
Coconut fatty acid diethanolamine 1.5
Oil base triethoxy phosphate ester (BRIPHOS 03D) 1
Polyethylene glycol-amine condensation resin (POLYQUART H) [50% activity] 1.5
Antiseptic, pigment, salt 0.58
Intermediate (33) 10
Spice is an amount of
Water adds to 100
Embodiment 26
The % w/w
Sodium laureth sulfate (2 EP) [100%AD] 12
Polymer JR400 2.5
BRIPHOS 03D 2.5
Intermediate (34) 15
Magnesium sulfate 5
Spice is an amount of
Water adds to 100
Embodiment 27
Present embodiment also illustrates and is fit to the lotion that the part is used for scalp.
Lotion has following prescription:
The % w/w
Intermediate (35) 5
Minoxidil 1
Propan-2-ol 10
Ethanol 84
Embodiment 28
Present embodiment illustrates dust composition of the present invention, and it can be used for scalp in the part.
The % w/w
Converted starch 5
Chemically-modified cellulose-
Boric acid 10
Zinc oxide 5
Intermediate (36) 3
Minoxidil 5
Spice is an amount of
Chalk 10
Pulvis Talci adds to 100
Embodiment 29
Following examples illustrate lotion of the present invention, and it can be used on the scalp to prevent alopecia and to stimulate hair restoration the part.
The % w/w
Intermediate (37) 7
Glucose-1,4-lactone 2
Ethanol 16
Citric acid 1.05
Water adds to 100
Regulate PH to 4.2 with sodium hydroxide
Embodiment 30
Present embodiment illustrates shampoo, and its is fit to part and is used on the hair discharging the metabolism intermediate simultaneously to increase natural on-off cycles of hair growth and regeneration on scalp to clean hair.
Shampoo has following prescription:
The % w/w
Triethanolamine lauryl sulfate 16.8
Coconut diethanolamide 3.0
Hydroxypropyl emthylcellulose (1) 0.25
Semen Maydis pulp (80% solid) (2) 20.5
Dimethyl polysiloxane (3) 1.0
Cationic cellulose (4) 0.5
Ethanol (SDA 40) 9.0
Vinyl carboxyl polymer (5) 0.75
Intermediate (38) 8
Spice, pigment, antiseptic is an amount of
Water adds to 100
Acid or alkali are regulated PH to 6.5
1.-Methocel E4M（Dow Chemical）
2.-be equivalent to dextrose 42(Staley 1300)
3.-60000 centistoke (Viscasil, GEC)
4.-polymer J R 400
5.-Carbopol 941（BF Goodrich）
Embodiment 31
Present embodiment illustrates shampoo according to the invention.
At first, in Winkworth pair-Z-blade blender (model MZ150), mix the preemulsion that following composition is made polyisobutylene under the room temperature.
The % w/w
The composition of preemulsion
Vistanex
（1）58
Alipal CO-433
（2）1.4
Water 40.6
(1) polyisobutylene, molecular weight is about 60000, available from Exxon.
(2) poly-ethoxy ethylene (polyethoxylene) sodium sulfate of alkyl phenyl.
Then pre-emulsion is stirred down and mix with the additional composition of shampoo.Obtain the following final composition of composition:
Composition % w/w
Pre-emulsion 1.6
Sodium laureth sulfate 2EO 14
Cocoamidopropylbetaine 2
Euperlan PK900
（3）10
Jaguar Cl3S
（4）0.1
Citrulline 4
Formalin 0.05
BY 22-026
（5）0.4
NaCl 5
Spice, pigment is an amount of
Water adds to 100
(3) mixture of 2,2'-ethylenedioxybis(ethanol). distearate and SLES 2EO is available from Henkel.
(4) Guar hydroxypropyl trimonium chloride is available from Meyhall.
(5) polydimethylsiloxane, 50% aqueous emulsion derives from Toray Silicone.
Embodiment 32
The % w/w
SLES 2EO 16
Cocoamidopropyl betaine 2
Silicone emulsion
(1)4
Jaguar Cl3s 0.1
Dlornithine hydrochloride 5.5
Glycol distearate 5.0
Octopirox
（2）0.5
Antiseptic, pigment, spice is an amount of
Water adds to 100
(1) BY22-026, available from Toray silicon company limited, contain:
The % w/w
Lauryl alcohol ethoxylate 2EO 2
Lauryl alcohol ethoxylate 21EO 2
Polydimethylsiloxane (60000cS) 50
Antiseptic is an amount of
Water adds to 100
(2) Piroctone olamine is available from Hoechst.
Shampoo is with simple heating method preparation, promptly with paddle agitator in the time of 70 ℃, mixes except that spice from all compositions, mixture is slowly cooled off, adding spice when being lower than 40 ℃.
Embodiment 33
The % w/w
Ammonium lauryl sulfate/Zetesol AP 8
cocodiethanolamide 3
Arginine monohydrochloride 5.5
Ionol butylated hydroxytoluene (BHT) 0.05
BRIPHOS 03D
（1）1.05
Hydrolyzed silk protein 0.1
CARBOPOL 1342
（2）0.4
Polyethoxy lanoline 0.3
JAGUAR C13s 0.3
TIMIRON MP-1005
（3）0.06
Triethanolamine 0.8
Silicone emulsion (50%)
(4)6
Spice, antiseptic is an amount of
Water adds to 100
(1) mixture of phosphate ester and Polyethylene Glycol oleyl alcohol ether.
(2) contain the copolymer of carboxylic acid monomer and acrylate, available from Goodrich.
(3) titanium dioxide of Muscovitum coating is available from Merck.
(4) silicone emulsion contains 50%(weight) silicone oil (60000cs), 4%(weight) cetostearylalcohol and 25%(weight) SLES 2EO.
Ammonium lauryl sulfate/Laurel ether ammonium sulfate and BHT constantly are heated to 75 ℃ under the stirring in primary tank, with fusing BHT.
CARBOPOL 1342 stirred be dispersed in down in 50% water and the dispersion liquid of gained is joined in the primary tank.
Claims (19)
1, be fit to be locally applied on the mammal skin to increase, to strengthen or keep the compositions of hair growth, it comprises:
(i) the metabolism intermediate of the ornithine cycle of effective dose; they are selected from one group of chemical compound being made up of aminoacid; described chemical compound is an arginine; ornithine; citrulline and argininosuccinic acid; and the salt of the derivant of described amino acid whose ester, alkyl, acyl group, phosphoryl and peptide and described aminoacid and derivant thereof and protic acid salt and
(ii) acceptable excipient on the cosmetics to described metabolism intermediate; But condition is: by the weight of compositions, if compositions comprises the detergent of (by weight) more than 4% or 4%, the content of then described metabolism intermediate or derivatives thereof is more than 5%.
2, according to the compositions of claim 1, wherein the metabolism intermediate is selected from arginine, described arginic derivant, and salt and protic acid salt.
3, according to the compositions of claim 1, wherein the metabolism intermediate is selected from arginine and L-arginine monohydrochloride.
4, according to the compositions of claim 1, wherein the metabolism intermediate is selected from the derivant of ornithine, described ornithine, and salt and protic acid salt.
5, according to the compositions of claim 1, wherein the metabolism intermediate is selected from the derivant of citrulline, described citrulline, and salt and protic acid salt.
6, according to the compositions of claim 1, wherein the metabolism intermediate is selected from the derivant of argininosuccinic acid, described argininosuccinic acid, and salt and protic acid salt.
7, according to the compositions of claim 1, wherein the metabolism intermediate is selected from:
Arginine monohydrochloride
Dlornithine hydrochloride
Arginine sodium
L-Arginine phosphate., sodium salt
Argininosuccinic acid sodium
Argininosuccinic acid potassium
L-α-alanyl arginine monohydrochloride
L-cystyl ornithine
L-methionyl citrulline
L-arginyl arginine
L-ornithyl citrulline
L-glutaminate acyl arginine
L-glutaminate acyl citrulline
L-tyrosyl arginine
L-arginyl methionine
L-ornithyl methionine
L-melon aminoacyl methionine
L-arginyl aspartic acid
L-arginyl glutamic acid
L-arginyl leucine acetate
L-arginyl lysine acetate
L-arginyl phenylalanine acetate
L-ornithyl aspartic acid
The methylarginine dihydrochloride
The arginine ethyl ester dihydrochloride
The ethyl citrulline
The n-pro-pyl ornithine
The n-octyl arginine
The n-octyl citrulline
The n-octyl ornithine
8, according to the compositions of aforementioned arbitrary claim, wherein by the weight of compositions, the content of intermediate is 0.01-30%.
9, according to the compositions of claim 1, the content of its surfactant no more than by weight 4%.
10, increase, increase or keep the method for hair growth, it comprises a kind of compositions is applied on people's scalp; Described compositions includes:
(ⅰ) the metabolism intermediate or derivatives thereof of effective dose; they are selected from following amino-acid compound: arginine; ornithine; citrulline and argininosuccinic acid; and the salt of the derivant of described amino acid whose ester, alkyl, acyl group, phosphoryl and peptide and described aminoacid and derivant thereof and protic acid salt and
(ⅱ) to acceptable excipient on the cosmetics of described metabolism intermediate or derivatives thereof.
11, according to the method for claim 10, wherein the metabolism intermediate is selected from arginine, described arginic derivant, and salt and protic acid salt.
12, according to the method for claim 10, wherein the metabolism intermediate is selected from L-arginine and L-arginine monohydrochloride.
13, according to the method for claim 10, wherein the metabolism intermediate is selected from the derivant of ornithine, described ornithine, and salt and protic acid salt.
14, according to the method for claim 10, wherein the metabolism intermediate is selected from the derivant of citrulline, described citrulline, and salt and protic acid salt.
15, according to the method for claim 10, wherein the metabolism intermediate is selected from the derivant of argininosuccinic acid, described argininosuccinic acid, and salt and protic acid salt.
16, according to the method for claim 10, wherein the metabolism intermediate is selected from:
Arginine monohydrochloride
Dlornithine hydrochloride
Arginine sodium
The smart ammonia of phosphoric acid, sodium salt
Argininosuccinic acid sodium
Argininosuccinic acid potassium
L-α-alanyl arginine monohydrochloride
L-cystyl ornithine
L-methionyl citrulline
L-arginyl arginine
L-ornithyl citrulline
L-glutaminate acyl arginine
L-glutaminate acyl citrulline
L-tyrosyl arginine
L-arginyl methionine
L-ornithyl methionine
L-melon aminoacyl methionine
L-arginyl aspartic acid
L-arginyl glutamic acid
L-arginyl leucine acetate
L-arginyl lysine acetate
L-arginyl phenylalanine acetate
L-ornithyl aspartic acid
The methylarginine dihydrochloride
The arginine ethyl ester dihydrochloride
The ethyl citrulline
The n-pro-pyl ornithine
The n-octyl arginine
The n-octyl citrulline
The n-octyl ornithine
17, according to the method for claim 10, wherein compositions contains 0.01-30%(weight) described metabolism intermediate or derivatives thereof.
18, according to the method for claim 10, wherein compositions contains no more than 4%(weight) surfactant.
19, according to the method for claim 10, wherein compositions contains 4%(weight at least) surfactant and more than 5%(weight) described metabolism intermediate or derivatives thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9222772.7 | 1992-10-30 | ||
| GB929222772A GB9222772D0 (en) | 1992-10-30 | 1992-10-30 | Cosmetic composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1091952A true CN1091952A (en) | 1994-09-14 |
Family
ID=10724275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93119716A Pending CN1091952A (en) | 1992-10-30 | 1993-10-29 | Cosmetic composition |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0666729A1 (en) |
| JP (1) | JPH08502509A (en) |
| KR (1) | KR950703926A (en) |
| CN (1) | CN1091952A (en) |
| AU (1) | AU5342694A (en) |
| CA (1) | CA2146348A1 (en) |
| GB (1) | GB9222772D0 (en) |
| TW (1) | TW262384B (en) |
| WO (1) | WO1994009750A1 (en) |
| ZA (1) | ZA938000B (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526250A (en) * | 2010-12-24 | 2012-07-04 | 漆又毛 | Application of composition of amino acids and extracts in preparation of drugs with function of improving memory |
| CN104736135A (en) * | 2012-10-17 | 2015-06-24 | 味之素株式会社 | Cosmetic composition |
| CN107573404A (en) * | 2017-09-22 | 2018-01-12 | 南京优科生物医药研究有限公司 | The active salt of the dipeptide compound of ornithine and L-aminobutanedioic acid and its application |
| CN109475483A (en) * | 2016-03-24 | 2019-03-15 | 凯塞尔德国有限公司 | Aspartyl dipeptide for skin nursing and cosmetic use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19520662A1 (en) * | 1995-06-07 | 1996-12-12 | Beiersdorf Ag | Treatment for dandruff and hair |
| JPH09278630A (en) * | 1996-02-15 | 1997-10-28 | Kao Corp | Hair cosmetic |
| DE69625620T2 (en) * | 1996-08-23 | 2003-08-21 | Sederma Sa | SYNTHETIC PEPTIDES AND THEIR USE IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS |
| TW505521B (en) * | 1997-06-25 | 2002-10-11 | Kao Corp | Hair cosmetics |
| US7914814B2 (en) | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
| US7629384B2 (en) * | 1997-09-17 | 2009-12-08 | Strategic Science & Technologies, Llc | Topical delivery of L-arginine to cause beneficial effects |
| JPH11279040A (en) * | 1998-03-27 | 1999-10-12 | Kao Corp | Composition for external use for skin |
| GB9811754D0 (en) * | 1998-06-01 | 1998-07-29 | Unilever Plc | Hair treatment compositions |
| FR2786693B1 (en) * | 1998-12-04 | 2003-01-17 | Dior Christian Parfums | COSMETIC AGENT TO OBTAIN A SLIMMING ACTION |
| AU2459100A (en) * | 1999-02-10 | 2000-08-29 | Taisho Pharmaceutical Co., Ltd. | Hair growth stimulants and method for screening substance having hair growth stimulating effect |
| DE29906038U1 (en) * | 1999-04-01 | 1999-07-15 | Maindok | Hair tonic |
| GB9917453D0 (en) | 1999-07-23 | 1999-09-29 | Unilever Plc | Method of hair treatment using organic amino compounds |
| GB9917452D0 (en) | 1999-07-23 | 1999-09-29 | Unilever Plc | Method of hair treatment using organic amino compounds |
| JP2007532697A (en) | 2004-04-19 | 2007-11-15 | ストラテジック サイエンス アンド テクノロジーズ， エルエルシー | The beneficial effects of increased local blood flow |
| US9226909B2 (en) | 2004-04-19 | 2016-01-05 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| US8858968B2 (en) | 2005-12-05 | 2014-10-14 | L'oreal | Use of tyrosine-arginine dipeptide and niacinamide as substance P antagonist |
| FR2894142B1 (en) * | 2005-12-05 | 2009-06-12 | Oreal | USE OF THE TYROSINE-ARGININE DIPEPTIDE AND NIACIMANIDE ASSOCIATION AS A P-SUBSTANCE ANAGONIST |
| WO2007142349A1 (en) * | 2006-06-08 | 2007-12-13 | Ajinomoto Co., Inc. | Hair growth composition |
| WO2009003808A1 (en) * | 2007-07-03 | 2009-01-08 | Unilever Plc | Hair styling composition |
| EP2033623A1 (en) * | 2007-09-07 | 2009-03-11 | Cutech S.R.L. | Compositions comprising ornithine ketoglutarate (OKG) |
| FR2929118B1 (en) * | 2008-03-28 | 2010-05-07 | Oreal | USE OF THE ASSOCIATION OF MADECASSOSIDE AND / OR TERMINOLOSIDE AND ARGININE TO INDUCE AND / OR STIMULATE THE GROWTH OF HUMAN KERATIN FIBERS AND / OR BRAKE THEIR FALL |
| FR2943253B1 (en) * | 2009-03-20 | 2011-04-22 | Oreal | COMPOSITION CONTAINING THE ASSOCIATION OF MADECASSOSIDE, ARGININE AND POLYSORBATE |
| EP2445493A1 (en) | 2009-06-24 | 2012-05-02 | Strategic Science & Technologies, LLC | Topical composition containing naproxen |
| US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| EP3045171A1 (en) | 2009-06-24 | 2016-07-20 | Strategic Science & Technologies, LLC | Topical composition |
| US9289495B2 (en) | 2010-12-29 | 2016-03-22 | Strategic Science & Technologies, Llc | Systems and methods for treatment of allergies and other indications |
| CN103429247A (en) | 2010-12-29 | 2013-12-04 | 战略科学与技术有限责任公司 | Treatment of erectile dysfunction and other indication |
| WO2013190567A2 (en) * | 2012-06-19 | 2013-12-27 | Shome Debraj | Composition and method for an intradermal hair growth solution |
| JP6115086B2 (en) * | 2012-11-13 | 2017-04-19 | 味の素株式会社 | Cosmetic composition containing acetate of amino acid compound |
| WO2015062629A1 (en) | 2013-10-29 | 2015-05-07 | Cutech Srl | Use of mono ornithine ketoglutarate (mokg) |
| FR3022778A1 (en) * | 2014-06-30 | 2016-01-01 | Oreal | USE OF A COMBINATION OF ORNITHINE AND CITRIC ACID TO LIMIT HAIR LOSS |
| JP7169623B2 (en) * | 2018-02-14 | 2022-11-11 | 株式会社 リトル・サイエンティスト | Cosmetic containing arginine ester |
| JPWO2021193820A1 (en) | 2020-03-26 | 2021-09-30 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL120093C (en) * | 1958-07-24 | |||
| DE3118882C2 (en) * | 1981-05-13 | 1985-11-14 | Rudolf V. Dr.rer.nat Dipl.-Chem. 5024 Pulheim Noronha | Hair loss and hair growth agents |
| JPS59196809A (en) * | 1983-04-22 | 1984-11-08 | Lion Corp | Hair cosmetic composition |
| JPS61151109A (en) * | 1984-12-26 | 1986-07-09 | Lion Corp | Hair treatment composition |
| JPS61246130A (en) * | 1985-04-24 | 1986-11-01 | Japan Fine Chem Kk | External agent for stimulation skin cell activity |
| JPH01242517A (en) * | 1988-03-25 | 1989-09-27 | Ajinomoto Co Inc | Hair cosmetic composition |
| FR2669224B1 (en) * | 1990-11-15 | 1995-04-28 | Marcel Contier | HAIR COMPOSITIONS, IN PARTICULAR FOR THE NEUTRALIZATION OF LACTIC ACID FROM SCALP AND METHOD OF COSMETIC TREATMENT OF SCALP. |
| JPH04308523A (en) * | 1991-04-04 | 1992-10-30 | Kanebo Ltd | Hair-tonic cosmetic |
| DE4205931A1 (en) * | 1992-02-20 | 1993-08-26 | Maindok Friedrich | Use of infusion soln. of electrolyte concentrate of arginine hydrochloride - prevents hair fallout and promotes hair growth |
| GB9210768D0 (en) * | 1992-05-20 | 1992-07-08 | Unilever Plc | Cosmetic composition |
-
1992
- 1992-10-30 GB GB929222772A patent/GB9222772D0/en active Pending
-
1993
- 1993-10-27 JP JP6510821A patent/JPH08502509A/en active Pending
- 1993-10-27 CA CA002146348A patent/CA2146348A1/en not_active Abandoned
- 1993-10-27 AU AU53426/94A patent/AU5342694A/en not_active Abandoned
- 1993-10-27 EP EP93923626A patent/EP0666729A1/en not_active Withdrawn
- 1993-10-27 WO PCT/GB1993/002210 patent/WO1994009750A1/en not_active Application Discontinuation
- 1993-10-27 ZA ZA938000A patent/ZA938000B/en unknown
- 1993-10-29 CN CN93119716A patent/CN1091952A/en active Pending
-
1994
- 1994-01-12 TW TW083100214A patent/TW262384B/zh active
-
1995
- 1995-04-29 KR KR1019950701705A patent/KR950703926A/en not_active Application Discontinuation
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526250A (en) * | 2010-12-24 | 2012-07-04 | 漆又毛 | Application of composition of amino acids and extracts in preparation of drugs with function of improving memory |
| CN104736135A (en) * | 2012-10-17 | 2015-06-24 | 味之素株式会社 | Cosmetic composition |
| CN104736135B (en) * | 2012-10-17 | 2019-07-09 | 味之素株式会社 | Cosmetic composition |
| US10463594B2 (en) | 2012-10-17 | 2019-11-05 | Ajinomoto Co., Inc. | Cosmetic composition |
| CN109475483A (en) * | 2016-03-24 | 2019-03-15 | 凯塞尔德国有限公司 | Aspartyl dipeptide for skin nursing and cosmetic use |
| CN107573404A (en) * | 2017-09-22 | 2018-01-12 | 南京优科生物医药研究有限公司 | The active salt of the dipeptide compound of ornithine and L-aminobutanedioic acid and its application |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9222772D0 (en) | 1992-12-09 |
| TW262384B (en) | 1995-11-11 |
| AU5342694A (en) | 1994-05-24 |
| KR950703926A (en) | 1995-11-17 |
| ZA938000B (en) | 1995-04-28 |
| EP0666729A1 (en) | 1995-08-16 |
| JPH08502509A (en) | 1996-03-19 |
| WO1994009750A1 (en) | 1994-05-11 |
| CA2146348A1 (en) | 1994-05-11 |
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