CN109182033A - A kind of Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity and preparation method thereof - Google Patents
A kind of Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wines of a kind of strengthen immunity and preparation method thereof, belong to field of health care wine, the present invention is with Notogineng Extract, Rhizoma Polygonati extract and Radix Codonopsis extract after certain proportion compatibility with 50 degree of white spirit mixings to form, and choose different extraction processes respectively according to the characteristic of each raw material, wherein Notogineng Extract and Radix Codonopsis extract are extracted using alcohol extraction process, Rhizoma Polygonati extract is extracted with extraction process by water, the proportion of each extract are as follows: Notogineng Extract 20~50%, Rhizoma Polygonati extract 25~43%, Radix Codonopsis extract 14~40%, inventive formulation is made of the raw material of integration of drinking and medicinal herbs with the raw material that can be used for health food, all meet the requirement of Ricipe for health care food on from the dosage of effective compatibility and safety, this formula is safe and effective；Health liquor prepared by the present invention has absorption fast, and effect is rapid, and quality is stablized, and convenient for taking, the high advantage of bioavilability has the efficacy of immunity that is significantly improved.
Description
Technical field
The invention belongs to field of health care wine, specifically, are related to a kind of Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity
And preparation method thereof.
Background technique
Traditional Chinese Medicine is of extensive knowledge and profound scholarship, is also a kind of common health-care method using health liquor is produced after Chinese herbal medicine soaking, at present
Health liquor on the market is all to be made after having Chinese medicine with white wine immersion for a long time, and only lean on soak at room temperature mostly, in Chinese medicine
Effective component leaching rate is lower.In addition, it is identical as the raw material of alcohol extracting to bubble out effective component in Chinese medicine with steeping in wine, but in having at
The suitable alcohol extracting that pharmaceutically active ingredient is suitble to water to mention, have, and the extraction of current health liquor effective component is substantially using alcohol extracting
Raw material, this causes the effective component of drug that cannot effectively be leached.
Summary of the invention
In view of the above-mentioned problems, the present invention provides a kind of Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity, directly with mentioning
It takes object to prepare health liquor, and chooses different extraction processes for the characteristic of different pharmaceutical and extract its effective component, recovery rate is more
Height, drug effect are also more preferable, and the health liquor prepared can significantly improve the immunity of people, have high health-care effect.
In consideration of it, one of the objects of the present invention is to provide a kind of Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wines of strengthen immunity:
The Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of the strengthen immunity is by Notogineng Extract, Rhizoma Polygonati extract and Radix Codonopsis extract
It is formed with certain compatibility with white spirit mixed.
Preferably, each extract is prepared as following weight percent: Notogineng Extract 20~50%, rhizoma polygonati extract
Object 25~43%, Radix Codonopsis extract 14~40%.
Another object of the present invention is to provide a kind of preparation method of the Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity,
It is characterised by comprising:
(1) Notogineng Extract is made using alcohol extraction process using Radix Notoginseng as raw material；
(2) Rhizoma Polygonati extract is made using extraction process by water using rhizoma polygonati as raw material；
(3) Radix Codonopsis extract is made using alcohol extraction process using Radix Codonopsis as raw material；
(4) by said extracted object and 50 degree of white spirit mixeds up to the Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity.
Preferably, the preparation of the Notogineng Extract includes the following steps:
(1) Radix Notoginseng powder prepares: will cross 10 meshes after Radix Notoginseng cleaning, dry, smashing；
(2) alcohol extracting three times: being that 85% ethyl alcohol is mixed with the mass ratio of 1:10 by Radix Notoginseng powder and concentration, 90 degree at a temperature of extract 2
Hour, obtain an extracting solution；85% ethyl alcohol will be added with the mass ratio of 1:10 by the Radix Notoginseng powder once extracted, in 90 degree of temperature
Degree is lower to be extracted 1.5 hours, and secondary raffinate is obtained；85% ethyl alcohol is added with the mass ratio of 1:10 in Radix Notoginseng powder Jing Guo second extraction,
90 degree at a temperature of extract 1.0 hours, obtain extracting solution three times；
(3) extracting solution filters: by an extracting solution, secondary raffinate and the extracting solution successively mistake in the same filter device three times
Filter respectively obtains primary extraction filtrate, second extraction filtrate and extracts filtrate three times；
(4) extracting solution is concentrated: it will once extract filtrate, second extraction filtrate and extraction filtrate is concentrated in vacuo respectively three times,
Obtain Notogineng Extract；
(5) extract mixes: by the extract obtained mixing of step (4) to get Notogineng Extract.
Preferably, the preparation of the Rhizoma Polygonati extract includes the following steps:
(1) rhizoma polygonati prepares: rhizoma polygonati being cleaned up and is sliced after steaming；
(2) water mentions three times: rhizoma polygonati piece is mixed with distilled water with the mass ratio of 1:10,95 degree at a temperature of extract 1.5 hours,
Obtain an extracting solution；Distilled water will be added with the mass ratio of 1:8 by the rhizoma polygonati that once extracts, 95 degree at a temperature of extract
1.0 hours, obtain secondary raffinate；Distilled water is added with the mass ratio of 1:6 in rhizoma polygonati Jing Guo second extraction, in 95 degree of temperature
It is lower to extract 1.0 hours, obtain extracting solution three times；
(3) extracting solution filters: by an extracting solution, secondary raffinate and the extracting solution successively mistake in the same filter device three times
Filter respectively obtains primary extraction filtrate, second extraction filtrate and extracts filtrate three times；
(4) extracting solution is concentrated: by it is primary extract filtrate, second extraction filtrate and three times extract filtrate respectively 75 DEG C at a temperature of
It is concentrated in vacuo, obtains Rhizoma Polygonati extract；
(5) extract mixes: by the extract obtained mixing of step (4) to get Rhizoma Polygonati extract.
Preferably, the preparation of the Radix Codonopsis extract includes the following steps:
(1) codonopsis pilosula powder prepares: will cross 10 meshes after Radix Codonopsis cleaning, dry, smashing；
(2) alcohol extracting three times: codonopsis pilosula powder is mixed with 75% ethyl alcohol with the mass ratio of 1:10,60 degree at a temperature of extract 2 hours,
Obtain an extracting solution；75% ethyl alcohol will be added with the mass ratio of 1:8 by the codonopsis pilosula powder once extracted, 60 degree at a temperature of mention
It takes 1.5 hours, obtains secondary raffinate；75% ethyl alcohol is added with the mass ratio of 1:6 in codonopsis pilosula powder Jing Guo second extraction, at 60 degree
At a temperature of extract 1.0 hours, obtain extracting solution three times；
(3) extracting solution filters: by an extracting solution, secondary raffinate and the extracting solution successively mistake in the same filter device three times
Filter respectively obtains primary extraction filtrate, second extraction filtrate and extracts filtrate three times；
(4) extracting solution is concentrated: it will once extract filtrate, second extraction filtrate and extraction filtrate is concentrated in vacuo respectively three times,
Obtain Radix Codonopsis extract；
(5) extract mixes: by the extract obtained mixing of step (4) to get Notogineng Extract.
As preferred: tri- kinds of specification food-grade vial packing of 125ml, 250ml, 500ml can be selected in obtained health liquor.
Beneficial effects of the present invention:
The present invention breaks traditional health liquor preparation process, creatively directly prepares health liquor with extract and white spirit mixed,
The defect that white wine leaching rate is low, soaking time is long is overcome, and the effective component extraction rate of raw material is higher；The present invention is according to each medicine
The characteristic of object, different raw materials select different extraction processes, not only further increase effective component, and extraction process is also more
Rationally；The proportion of extract of the invention be obtained for the purpose of improving the immunity of the human body, by lot of experiment validation it is best
Compatibility generates good synergistic effect between each extract under the compatibility, and health-care effect becomes apparent from；Inventive formulation is eaten same by medicine
The raw material in source and the raw material composition that can be used for health food, all meet Ricipe for health care food from effective compatibility and safe dosage
Requirement, this formula is safe and effective；Health liquor prepared by the present invention has and absorbs fastly, and rapidly, quality is stablized for effect, convenient for taking
With the high advantage of bioavilability has the efficacy of immunity that is significantly improved.
Specific embodiment
It, below will be to preferred reality of the invention in order to keep the purpose of the present invention, technical scheme and beneficial effects clearer
It applies example to be described in detail, to facilitate the technical staff to understand.
Embodiment 1
Notogineng Extract preparation:
(1) Radix Notoginseng powder prepares: will cross 10 meshes after Radix Notoginseng cleaning, dry, smashing；
(2) alcohol extracting three times: being that 85% ethyl alcohol is mixed with the mass ratio of 1:10 by Radix Notoginseng powder and concentration, 90 degree at a temperature of extract 2
Hour, obtain an extracting solution；85% ethyl alcohol will be added with the mass ratio of 1:10 by the Radix Notoginseng powder once extracted, in 90 degree of temperature
Degree is lower to be extracted 1.5 hours, and secondary raffinate is obtained；85% ethyl alcohol is added with the mass ratio of 1:10 in Radix Notoginseng powder Jing Guo second extraction,
90 degree at a temperature of extract 1.0 hours, obtain extracting solution three times；
(3) extracting solution filters: by an extracting solution, secondary raffinate and the extracting solution successively mistake in the same filter device three times
Filter respectively obtains primary extraction filtrate, second extraction filtrate and extracts filtrate three times；
(4) extracting solution is concentrated: will once extract filtrate, second extraction filtrate and extraction filtrate is concentrated in vacuo to respectively three times
Extractive content >=99% obtains Notogineng Extract；
(5) extract mixes: by the extract obtained mixing of step (4) to get Notogineng Extract.
The preparation of Rhizoma Polygonati extract:
(1) rhizoma polygonati prepares: rhizoma polygonati being cleaned up and is sliced after steaming；
(2) water mentions three times: rhizoma polygonati piece is mixed with distilled water with the mass ratio of 1:10,95 degree at a temperature of extract 1.5 hours,
Obtain an extracting solution；Distilled water will be added with the mass ratio of 1:8 by the rhizoma polygonati that once extracts, 95 degree at a temperature of extract
1.0 hours, obtain secondary raffinate；Distilled water is added with the mass ratio of 1:6 in rhizoma polygonati Jing Guo second extraction, in 95 degree of temperature
It is lower to extract 1.0 hours, obtain extracting solution three times；
(3) extracting solution filters: by an extracting solution, secondary raffinate and the extracting solution successively mistake in the same filter device three times
Filter respectively obtains primary extraction filtrate, second extraction filtrate and extracts filtrate three times；
(4) extracting solution is concentrated: by it is primary extract filtrate, second extraction filtrate and three times extract filtrate respectively 75 DEG C at a temperature of
It carries out being concentrated in vacuo to extractive content >=99%, obtains Rhizoma Polygonati extract；
(5) extract mixes: by the extract obtained mixing of step (4) to get Rhizoma Polygonati extract.
The preparation of Radix Codonopsis extract:
(1) codonopsis pilosula powder prepares: will cross 10 meshes after Radix Codonopsis cleaning, dry, smashing；
(2) alcohol extracting three times: codonopsis pilosula powder is mixed with 75% ethyl alcohol with the mass ratio of 1:10,60 degree at a temperature of extract 2 hours,
Obtain an extracting solution；75% ethyl alcohol will be added with the mass ratio of 1:8 by the codonopsis pilosula powder once extracted, 60 degree at a temperature of mention
It takes 1.5 hours, obtains secondary raffinate；75% ethyl alcohol is added with the mass ratio of 1:6 in codonopsis pilosula powder Jing Guo second extraction, at 60 degree
At a temperature of extract 1.0 hours, obtain extracting solution three times；
(3) extracting solution filters: by an extracting solution, secondary raffinate and the extracting solution successively mistake in the same filter device three times
Filter respectively obtains primary extraction filtrate, second extraction filtrate and extracts filtrate three times；
(4) extracting solution is concentrated: will once extract filtrate, second extraction filtrate and extraction filtrate is concentrated in vacuo to respectively three times
Extractive content >=99% obtains Radix Codonopsis extract；
(5) extract mixes: by the extract obtained mixing of step (4) to get Notogineng Extract.
Health liquor is blent:
After Notogineng Extract, Rhizoma Polygonati extract, Radix Codonopsis extract are mixed with the ratio of 3:3:2, with 50 degree of white wine with 6 times of matter
Amount after mixing with 125m food-grade vial than being dispensed.
Embodiment 2
Radix Notoginseng, rhizoma polygonati and Radix Codonopsis extract are produced respectively for method same as Example 1, and Notogineng Extract, rhizoma polygonati are mentioned
After taking object, Radix Codonopsis extract to mix with the ratio of 3:3:1,125m food-grade is used after mixing with 50 degree of white wine with 6 times of mass ratio
Vial packing.
Embodiment 3:
Radix Notoginseng, rhizoma polygonati and Radix Codonopsis extract are produced respectively for method same as Example 1, and Notogineng Extract, rhizoma polygonati are mentioned
After taking object, Radix Codonopsis extract to mix with the ratio of 3:2:2,125m food-grade is used after mixing with 50 degree of white wine with 6 times of mass ratio
Vial packing.
Embodiment 4:
Radix Notoginseng, rhizoma polygonati and Radix Codonopsis extract are produced respectively for method same as Example 1, and Notogineng Extract, rhizoma polygonati are mentioned
After taking object, Radix Codonopsis extract to mix with the ratio of 3:2:1,125m food-grade is used after mixing with 50 degree of white wine with 6 times of mass ratio
Vial packing.
Embodiment 5:
Radix Notoginseng, rhizoma polygonati and Radix Codonopsis extract are produced respectively for method same as Example 1, and Notogineng Extract, rhizoma polygonati are mentioned
After taking object, Radix Codonopsis extract to mix with the ratio of 2:2:1,125m food-grade is used after mixing with 50 degree of white wine with 6 times of mass ratio
Vial packing.
Embodiment 6:
Radix Notoginseng, rhizoma polygonati and Radix Codonopsis extract are produced respectively for method same as Example 1, and Notogineng Extract, rhizoma polygonati are mentioned
After taking object, Radix Codonopsis extract to mix with the ratio of 2:1:1,125m food-grade is used after mixing with 50 degree of white wine with 6 times of mass ratio
Vial packing.
Embodiment 7:
Radix Notoginseng, rhizoma polygonati and Radix Codonopsis extract are produced respectively for method same as Example 1, and Notogineng Extract, rhizoma polygonati are mentioned
After taking object, Radix Codonopsis extract to mix with the ratio of 1:2:2,125m food-grade is used after mixing with 50 degree of white wine with 6 times of mass ratio
Vial packing.
Embodiment 8:
Radix Notoginseng, rhizoma polygonati and Radix Codonopsis extract are produced respectively for method same as Example 1, and Notogineng Extract, rhizoma polygonati are mentioned
After taking object, Radix Codonopsis extract to mix with the ratio of 1:2:1,125m food-grade is used after mixing with 50 degree of white wine with 6 times of mass ratio
Vial packing.
Embodiment 9:
Radix Notoginseng, rhizoma polygonati and Radix Codonopsis extract are produced respectively for method same as Example 1, and Notogineng Extract, rhizoma polygonati are mentioned
After taking object, Radix Codonopsis extract to mix with the ratio of 1:1:1,125m food-grade is used after mixing with 50 degree of white wine with 6 times of mass ratio
Vial packing.
Improve immunity test:
Selection healthy mice 100 takes orally cyclophosphamide 40mg/Kg/d weight, after continuously taking 7 days, is randomly divided into 10 groups,
Every group 10, wherein 1 group is without any processing, as blank control group, remaining 9 groups of 1~embodiment of difference feeding embodiment 9
Health liquor is continuously mixed into feeding 60 days in feed according to the amount feeding of 10mL/kg/d, stops feeding 1 day, 62d, it is small to put to death each group
Mouse weighs the weight of each group mouse, thymus gland and spleen weight, calculates thymus index and index and spleen index, compares the difference between each group.
Individual cells suspension is made to the spleen of laboratory mouse simultaneously, T cell subgroup content is detected with drain cell instrument, is predominantly detected
Helper lymphocyte T (CD4+) and cytotoxic T lymphocyte (CD8+).
The good index and spleen index calculation method of thymus index:
Thymus index (mg/10g weight)=thymic weight/weight
Index and spleen index (mg/10g weight)=spleen weight/weight
Table 1 influences comparison table to Thymus and Spleen index
As can be seen from the above table: compared with blank control group, eaten embodiment 1 to embodiment 9 small white mouse thymus index
Obviously rise with index and spleen index.
Table 2 influences comparison table to T cell
As can be seen from the above table: compared with blank control group, eaten embodiment 1 to embodiment 9 small white mouse T lymphocyte
(CD4+) obvious rising, cytotoxic T lymphocyte (CD8+) are decreased obviously.
To sum up, in terms of test result: health liquor of the invention can obviously offset destruction of the cyclophosphamide to immunity,
Health wine set of the invention is significantly improved the health-care effect of immunity.
Finally, it is stated that preferred embodiment above is only used to illustrate the technical scheme of the present invention rather than limits, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (6)
1. a kind of Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity, it is characterised in that: be by Notogineng Extract, Rhizoma Polygonati extract
It is formed with certain compatibility with white spirit mixed with Radix Codonopsis extract.
2. a kind of Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity according to claim 1, it is characterised in that: described each
Extract is prepared as following weight percent: Notogineng Extract 20~50%, Rhizoma Polygonati extract 25~43%, Radix Codonopsis extract 14~
40%。
3. a kind of preparation method of the Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity, it is characterised in that:
(1) Notogineng Extract is made using alcohol extraction process using Radix Notoginseng as raw material；
(2) Rhizoma Polygonati extract is made using extraction process by water using rhizoma polygonati as raw material；
(3) Radix Codonopsis extract is made using alcohol extraction process using Radix Codonopsis as raw material；
(4) by said extracted object and 50 degree of white spirit mixeds up to the Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity.
4. a kind of preparation method of the Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity according to claim 3, feature
It is that the preparation of Notogineng Extract includes the following steps:
(1) Radix Notoginseng powder prepares: will cross 10 meshes after Radix Notoginseng cleaning, dry, smashing；
(2) alcohol extracting three times: being that 85% ethyl alcohol is mixed with the mass ratio of 1:10 by Radix Notoginseng powder and concentration, 90 degree at a temperature of extract 2
Hour, obtain an extracting solution；85% ethyl alcohol will be added with the mass ratio of 1:10 by the Radix Notoginseng powder once extracted, in 90 degree of temperature
Degree is lower to be extracted 1.5 hours, and secondary raffinate is obtained；85% ethyl alcohol is added with the mass ratio of 1:10 in Radix Notoginseng powder Jing Guo second extraction,
90 degree at a temperature of extract 1.0 hours, obtain extracting solution three times；
(3) extracting solution filters: by an extracting solution, secondary raffinate and the extracting solution successively mistake in the same filter device three times
Filter respectively obtains primary extraction filtrate, second extraction filtrate and extracts filtrate three times；
(4) extracting solution is concentrated: it will once extract filtrate, second extraction filtrate and extraction filtrate is concentrated in vacuo respectively three times,
Obtain Notogineng Extract；
(5) extract mixes: by the extract obtained mixing of step (4) to get Notogineng Extract.
5. a kind of preparation method of the Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity according to claim 3, feature
It is that the preparation of Rhizoma Polygonati extract includes the following steps:
(1) rhizoma polygonati prepares: rhizoma polygonati being cleaned up and is sliced after steaming；
(2) water mentions three times: rhizoma polygonati piece is mixed with distilled water with the mass ratio of 1:10,95 degree at a temperature of extract 1.5 hours,
Obtain an extracting solution；Distilled water will be added with the mass ratio of 1:8 by the rhizoma polygonati that once extracts, 95 degree at a temperature of extract
1.0 hours, obtain secondary raffinate；Distilled water is added with the mass ratio of 1:6 in rhizoma polygonati Jing Guo second extraction, in 95 degree of temperature
It is lower to extract 1.0 hours, obtain extracting solution three times；
(3) extracting solution filters: by an extracting solution, secondary raffinate and the extracting solution successively mistake in the same filter device three times
Filter respectively obtains primary extraction filtrate, second extraction filtrate and extracts filtrate three times；
(4) extracting solution is concentrated: by it is primary extract filtrate, second extraction filtrate and three times extract filtrate respectively 75 DEG C at a temperature of
It is concentrated in vacuo, obtains Rhizoma Polygonati extract；
(5) extract mixes: by the extract obtained mixing of step (4) to get Rhizoma Polygonati extract.
6. a kind of preparation method of the Radix Notoginseng rhizoma polygonati Codonopsis pilosula health wine of strengthen immunity according to claim 3, feature
It is that the preparation of Radix Codonopsis extract includes the following steps:
(1) codonopsis pilosula powder prepares: will cross 10 meshes after Radix Codonopsis cleaning, dry, smashing；
(2) alcohol extracting three times: codonopsis pilosula powder is mixed with 75% ethyl alcohol with the mass ratio of 1:10,60 degree at a temperature of extract 2 hours,
Obtain an extracting solution；75% ethyl alcohol will be added with the mass ratio of 1:8 by the codonopsis pilosula powder once extracted, 60 degree at a temperature of mention
It takes 1.5 hours, obtains secondary raffinate；75% ethyl alcohol is added with the mass ratio of 1:6 in codonopsis pilosula powder Jing Guo second extraction, at 60 degree
At a temperature of extract 1.0 hours, obtain extracting solution three times；
(3) extracting solution filters: by an extracting solution, secondary raffinate and the extracting solution successively mistake in the same filter device three times
Filter respectively obtains primary extraction filtrate, second extraction filtrate and extracts filtrate three times；
(4) extracting solution is concentrated: it will once extract filtrate, second extraction filtrate and extraction filtrate is concentrated in vacuo respectively three times,
Obtain Radix Codonopsis extract；
(5) extract mixes: by the extract obtained mixing of step (4) to get Notogineng Extract.
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