CN109172715A - 一种治疗烧伤的少疤痕中药制剂 - Google Patents

一种治疗烧伤的少疤痕中药制剂 Download PDF

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CN109172715A
CN109172715A CN201811469388.4A CN201811469388A CN109172715A CN 109172715 A CN109172715 A CN 109172715A CN 201811469388 A CN201811469388 A CN 201811469388A CN 109172715 A CN109172715 A CN 109172715A
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胡立发
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Abstract

一种治疗烧伤的中药制剂，该中药制剂由下列组分配比制成：虎杖、地榆、大黄、蜂胶、降龙草、见肿消、丁香油、蛋黄油、仙人掌、满江红、牛膝、三七、紫珠、血竭、蝉衣、冰片、百里香、土槿皮、蛇床子、凡士林，本发明具有止痛散淤快、活血止血快、排毒提浓快、缩水植皮快、皮肤结缘快、伤口愈合快、无毒无副作用等特点。本发明中大黄、蜂胶、仙人掌三者相互配合，可显著增强伤口处的愈合能力，治疗烧伤引起的系列症状，如局部出现红晕、起泡或腐烂等。降龙草、黄柏这两味药体外试验对金黄色葡萄球菌、肺炎球菌、白喉杆菌、草绿色链球菌、百日咳杆菌、破伤风杆菌、溶血性链球菌、脑膜炎球菌、霍乱弧菌、炭疽杆菌均有较强的抑制作用。

Description

一种治疗烧伤的少疤痕中药制剂
技术领域
本发明涉及中药制剂，尤其是一种治疗烧伤的中药制剂。
背景技术
皮肤烧伤、创伤、褥疮等是危害人类健康和生命安全的常见病症之一。其中皮肤烧伤是由热水、蒸汽、火焰、强酸、强碱、电流、放射线等原因所致的皮肤等组织的损伤。
烧伤的严重程度取决于受伤组织的范围和深度，目前烧伤深度可分为I°、II°和III°。其中，I°烧伤损伤最轻，烧伤皮肤呈现出发红、疼痛、有明显触痛、有渗出或水肿等症状，轻压受伤部位皮肤时局部变白。II°烧伤可以分为深II 度与浅II 度烧伤。其损伤较深，皮肤上一般产生水疱，水疱底部呈红色或白色，充满了清澈、粘稠的液体，触痛敏感，压迫受伤部位皮肤时变白。III°烧伤损伤最深，烧伤表面呈现出发白、变软或者呈黑色、炭化皮革状，压迫III°烧伤区域时一般没有痛觉，这是因为该处皮肤的神经末梢被破坏。
一般来说，深II°与III°烧伤的毛细血管的通透性高，伤面渗出增多。烧伤创面存在大量毁损及失活组织，是细菌繁殖的良好场所，可导致全身侵袭性感染。全身感染是目前严重烧伤患者主要的死亡原因之一。为了制止伤面渗出，维持患者血浆平衡，有效的防止创面感染、防止内脏的病理改变及多种并发症，当下迫切需要治疗效果显著、毒副作用小的抗烧伤中药制剂。
发明内容
本发明的目的在于提供一种治疗烧伤的中药制剂，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：一种治疗烧伤的中药制剂，该中药制剂由下列重量份的组分配比制成：虎杖160～180份、地榆200～250份、大黄100～200份、蜂胶200～250份、降龙草80～100份、见肿消100～150份、丁香油10～15份、蛋黄油100～150份、仙人掌70～100份、满江红50～80份、牛膝80～110份、三七50～70份、紫珠30～50份、血竭25～30份、蝉衣5～10份、冰片7～10份、百里香55～60份、土槿皮35～50份、蛇床子35～50份、凡士林1500份。
虎杖：具有利湿退黄、清热解毒、散瘀止痛、止咳化痰的功效。
地榆：具有止血凉血、清热解毒、收敛止泻及抑制多种致病微生物和肿瘤的作用。
大黄：具有攻积滞、清湿热、泻火、凉血、祛瘀、解毒的功效。
蜂胶：有润肤生肌、消炎止痛的功效。
降龙草：清热利湿、解毒、散瘀消肿的功效。
见肿消：通二便、泻水、散结。
丁香油：具有暖胃、降逆、温肾、止痛之功效。
蛋黄油：具有清热润肤、消炎止痛、收敛生肌和保护疮面的作用。
仙人掌：具有行气活血、清热解毒、消肿止痛、健脾止泻、安神利尿的功效。
满江红：可以祛风、解毒、胜湿。
牛膝：根入药、生用、活血通经。
三七：散瘀止血、消肿定痛。
紫珠：收敛止血、清热解毒。
血竭：具有活血定痛、化瘀止血、生肌敛疮的功效。
蝉衣：宣散风热、透疹利咽、退翳明目、祛风止痉。
冰片：具有开窍醒神、清热散毒、明目退翳的功效。
百里香：具有温中散寒，驱风止痛的功效。
土槿皮：具有止痒杀虫的功效。
蛇床子：具有温肾助阳，祛风，燥湿，杀虫。
凡士林：具有杀菌、抑菌、润滑、保护皮肤以防皲裂的功效。
本发明具有止痛散淤快、活血止血快、排毒提浓快、缩水植皮快、皮肤结缘快、伤口愈合快、无毒无副作用等特点。本发明中大黄、蜂胶、仙人掌三者相互配合，可显著增强伤口处的愈合能力，治疗烧伤引起的系列症状，如局部出现红晕、起泡或腐烂等。降龙草、黄柏这两味药体外试验对金黄色葡萄球菌、肺炎球菌、白喉杆菌、草绿色链球菌、百日咳杆菌、破伤风杆菌、溶血性链球菌、脑膜炎球菌、霍乱弧菌、炭疽杆菌均有较强的抑制作用。
具体实施方式
下面对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
一种治疗烧伤的中药制剂，该中药制剂由下列重量份的组分配比制成：虎杖180份、地榆200份、大黄100份、蜂胶200份、降龙草100份、见肿消150份、丁香油15份、蛋黄油150份、仙人掌70份、满江红50份、牛膝110份、三七70份、紫珠50份、血竭25份、蝉衣5份、冰片7份、百里香55份、土槿皮50份、蛇床子35份、凡士林1500份。将上述配比药剂用酒精泡制而成。
实施例2
一种治疗烧伤的中药制剂，该中药制剂由下列重量份的组分配比制成：虎杖170份、地榆230份、大黄150份、蜂胶220份、降龙草90份、见肿消130份、丁香油12份、蛋黄油120份、仙人掌90份、满江红70份、牛膝100份、三七60份、紫珠40份、血竭28份、蝉衣8份、冰片8份、百里香58份、土槿皮45份、蛇床子42份、凡士林1500份。
实施例3
一种治疗烧伤的中药制剂，该中药制剂由下列重量份的组分配比制成：虎杖160份、地榆250份、大黄200份、蜂胶250份、降龙草80份、见肿消100份、丁香油10份、蛋黄油100份、仙人掌100份、满江红80份、牛膝80份、三七50份、紫珠30份、血竭25份、蝉衣10份、冰片10份、百里香60份、土槿皮50份、蛇床子50份、凡士林1500份。
为了验证本发明的疗效，发明人对动物实验性烧烫伤进行药效试验。
一．实验材料：
1.实验动物：健康昆明种小鼠，体重18～24g，健康Wistar大鼠，体重180～200g，健康新西兰大白兔，体重1.7～2.3kg；
2.实验药物：本发明实施例1、实施例2、京万红软膏、凡士林。
二．实验方法与结果
1）对小鼠实验性烫伤的疗效试验：取健康昆明种小鼠40只，随机分为4组，即凡士林对照组、本发明实施例1组、实施例2组、采用CN201010132067专利制得的药物组，每组10只。用异戊巴比妥钠将小鼠麻醉后，背部脱毛，用熔化至120℃石蜡液滴至脱毛部位，造成深Ⅱ度烫伤，然后在烫伤部位涂抹给药，观察创面愈合时间并测取不同给药时间创面面积，其结果见表1。
表1：对小鼠实验性烫伤的疗效试验
由表1可见，本发明实施例1、2、3均可明显缩短烫伤后的创面愈合时间，与对照组凡士林相比、有非常显著差异，比CN201010132067专利制得的药物愈合速度更快，同时亦能使烫伤创面面积明显减小，说明药物能促进创面愈合，病理检查结果表明实施例1、2、3对皮肤损害基本修复，皮岛形成，皮脂腺和毛囊均增生。
2）对大鼠创面水肿的疗效试验：取健康Wistar大鼠40只，随机分为4组，即凡士林对照组、本发明实施例1组、实施例2组、京万红组，每组10只。大鼠用戊巴比妥钠麻醉，腹卧位固定，背部脱毛，用熔化至150℃石蜡液滴至脱毛部位，造成Ⅲ°烫伤，烫伤后各组立即涂抹所试药物，剂量同表一，3小时后每鼠颈静脉注射0.5%伊文思蓝0.5ml／100g，35分钟后擦净药物，剪下烫伤处蓝染皮片，并于对侧剪下等面积正常皮片，称出左右皮片重量差，即为水肿渗出增重值；然后将烫伤侧皮片剪碎，以丙酮生理盐水（丙酮∶生理盐水=7∶3）溶液5毫升浸泡24小时，将浸泡液按3000转/分钟的速度离心12分钟，静置，取上清液用722型分光光度计测定其透过率；结果见表1。
表2：对大鼠烫伤皮片增重值，浸出液透过率的试验
由表2可见，本发明（实施例1、2、3组）对创面皮片水肿增重值比凡士林对照组显著减轻，其浸出液透过率比凡士林对照组显著提高，表明本发明能显著降低毛细血管通透性，减少渗出、减轻水肿，其抗渗出作用非常显著。
3）对家兔实验性烫伤的疗效试验：取新西兰大白兔12 只，雌雄各半，随机分组，每组6只。家兔实验前24 小时脱毛，试验当天，用中间挖有3 cm×3 cm孔洞的石棉纸板置于各组家兔背上，用吸管取0.5 mL混合燃料涂在暴露处，点火燃烧20 s造成该处皮肤深Ⅱ度烧伤，然后各组按表2涂药，观察动物烧伤面积的愈合时间，结果见表2。
表3：对家兔实验性烫伤的影响
由表3可见，本发明（实施例1、2、3组）对创面愈合时间与对照组比较有显著差异。
为了进一步验证本发明对各种烧伤的治疗效果，发明人化了近8年的时间，先后对600例烧伤病患者进行试验性治疗和跟踪回访。试验时，随机选择500例烧伤病患者作为试验组，采用本发明进行治疗。随机选择100例烧伤病患者作为对照组，采用美宝湿润烧伤膏进行治疗。
试验组资料：本组病人共600例，男285例，女215例，患者年龄在1岁—62岁之间，烧伤总面积1%～60%，其中大面积23例。创面达到深II°的为53.6%,浅II°为32.5%，创面属深II°到Ⅲ°混合型烧伤为14.9%。致伤原因为热液、火焰、电、硫酸烧伤等。
治疗方法：对患者伤口进行常规清理消毒，将侵透本发明药剂的无菌纱布敷于伤口处，每日换药1～2次，深II°到Ⅲ°混合型烧伤加全身抗菌素治疗，至创面愈合。
对照组资料：本组病人共100例，其中男55例，女45例，年龄1岁半～60岁，烧伤总面积为3%～55%，其中大面积16例。创面达到深II°的为41%,浅II°为45%。创面属深II°到Ⅲ°混合型烧伤为14%。致伤原因为热液、火焰、电、硫酸烧伤等。
治疗方法：对患者伤口进行常规清理消毒，将美宝湿润烧伤膏涂于创面，每日换药2～3次，在保温条件下暴露创面，深II°到Ⅲ°混合型烧伤加全身抗菌素治疗，至创面愈合。
表4：临床试验统计结果
试验结果显示：本发明中药制剂对烧伤患者的确有着良好的治疗效果。其疤痕发生率较对照组明显降低。
以下是发明人近两年的试验性治疗中的部分病例：
1.张某某，男，家住湖北省天门市杨林中学附近，2016年3月由于不慎碰翻旁人手中开水碗将后颈部烫伤，经过连续使用本中药制剂7天后，伤口结瘤痊愈，十个月后伤口处无疤痕。
2.刘女士，女，家住湖北省天门市小板胡桥村一组，2016年6月夏天在家中不慎接触电网扇漏电线处，在猛力甩脱电线时，被电源线断头击中手臂，留下一个伤洞，伤口长期泌水不愈合，经过连续使用本中药制剂9天后，伤口愈合无疤痕。
3.李先生，男，家住湖北省天门市永合湾三组，2017年4月脚腕处因冻伤遗留症复发，在医院治疗6个月后无效并作出要截肢的处理时，经过他人介绍，经过使用本中药制剂18天后，伤处痊愈。
4.杨某某，5岁女孩，家住湖北省天门市横林镇小垸村，2017年5月背部不慎大面积烫伤后住进小板卫生院，后办理退院手续后，到本发明人处使用本中药制剂7天后痊愈，无任何疤痕。
对于本领域技术人员而言，显然本发明不限于上述示范性实施例的细节，而且在不背离本发明的精神或基本特征的情况下，能够以其他的具体形式实现本发明。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限制性的，本发明的范围由所附权利要求而不是上述说明限定，因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。
此外，应当理解，虽然本说明书按照实施方式加以描述，但并非每个实施方式仅包含一个独立的技术方案，说明书的这种叙述方式仅仅是为清楚起见，本领域技术人员应当将说明书作为一个整体，各实施例中的技术方案也可以经适当组合，形成本领域技术人员可以理解的其他实施方式。

Claims (1)

1.一种治疗烧伤的中药制剂，其特征在于该中药制剂由下列重量份的组分配比制成：虎杖160～180份、地榆200～250份、大黄100～200份、蜂胶200～250份、降龙草80～100份、见肿消100～150份、丁香油10～15份、蛋黄油100～150份、仙人掌70～100份、满江红50～80份、牛膝80～110份、三七50～70份、紫珠30～50份、血竭25～30份、蝉衣5～10份、冰片7～10份、凡士林1500份。
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