CN109172591A - A kind of preparation method for sterilizing fungicide in spray with oneself - Google Patents
A kind of preparation method for sterilizing fungicide in spray with oneself Download PDFInfo
- Publication number
- CN109172591A CN109172591A CN201811401289.2A CN201811401289A CN109172591A CN 109172591 A CN109172591 A CN 109172591A CN 201811401289 A CN201811401289 A CN 201811401289A CN 109172591 A CN109172591 A CN 109172591A
- Authority
- CN
- China
- Prior art keywords
- preparation
- fungicide
- parts
- oneself
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses the preparation methods of fungicide in a kind of sterilization spray with oneself, the following steps are included: S1: three kinds of antibiotic of preparation, S2: three obtained kind antibiotic in the extraction purification first step, and three kinds of antibiotic are uniformly mixed according to a certain percentage, obtain mixture one, S3: in parts by mass, including two parts of mixtures one, five parts of hydroxyl aluminium hydroxides, 15 parts of boric acid, 100 parts of water, obtain mixture two, S4: by mixture two obtained in S2 respectively with golden yellow staphylococcus, Escherichia coli, Candida albicans specifically binds and carries out antibacterial effect test, S5: toxotest, stomach-filling is carried out to mouse.Preparation method of the invention has good bactericidal effect, preparation method step of the invention is simple, reaction condition is easy to accomplish, and the fungicide produced through the invention can have preferable bactericidal effect, and the lesser advantage of toxicity is shown in Mice Body.
Description
Technical field
The present invention relates to bactericidal agent preparation field, the preparation method of fungicide in specially a kind of sterilization spray with oneself.
Background technique
Escherichia coli are a kind of parasitic pathogenic bacteria in animal body, contain endotoxin, endotoxin one on cell wall
Kind polysaccharide, has very strong toxicity to animal body, when serious, will lead to the death of host, seriously threatens the strong of animal
Health.
Staphylococcus aureus is a kind of Gram positive bacteria, is a kind of common bacteria for causing animal In vivo infection, perhaps
Multinational family is equipped with special mechanism to cope with the infection problems of golden staphylococci, it can be seen that it is endangered.
Candida albicans is a kind of fungi, and usually presence and human mouth, the upper respiratory tract, enteron aisle and vagina may cause
Pneumonia, enterogastritis etc., it is serious to cause septicemia.
The preparation method of existing fungicide is more toxic, and certain injury, and general sterilization can be brought to user
The preparation method of agent reacts more demanding, and reaction condition is not easy to realize.
Summary of the invention
The purpose of the present invention is to provide the preparation methods of fungicide in a kind of sterilization spray with oneself, to solve above-mentioned background skill
The problem of being proposed in art.
To achieve the above object, the invention provides the following technical scheme: a kind of preparation side for sterilizing fungicide in spray with oneself
Method, comprising the following steps:
S1: aminoglycoside antibiotics is prepared by oxygen bridge connection by amino sugar and aminocyclitol, is shifted using mutually catalysis
Technology is made Fluconazole antibiotic by difluorobenzene, produces antibiotic erythromycin by streptomysin；
S2: three obtained kind antibiotic in the extraction purification first step, and three kinds of antibiotic are mixed according to a certain percentage
Uniformly, mixture one is obtained；
S3: in parts by mass, including two parts of mixtures one, five parts of hydroxyl aluminium hydroxides, 15 parts of boric acid, 100 parts of water,
Obtain mixture two；
S4: mixture two obtained in S2 is carried out with golden yellow staphylococcus, Escherichia coli, Candida albicans respectively special
Property combines and carries out antibacterial effect test；
S5: oxicity analysis is carried out by the method to different intragastric administration on mice to mixture two obtained in step 3.
Preferably, the mixed proportion of the mixture is (1-2) part aminoglycoside antibiotics: (1-2) part Fluconazole is anti-
Raw element: (1-2) part antibiotic erythromycin.
Preferably, the method for the extraction purification has chromatographic column method, chromatography and centrifugal process etc..
Preferably, the method for the extraction purification that described this method uses is chromatography.
Preferably, the test method in the S4 is succusion.
Preferably, the mouse be health, just grow up, be not used, it is female do not produce and without pregnant, the weight of mouse is
18-22g, and individual mesosome heavy phase difference is no more than the 20% of average weight.
Preferably, the quantity of the mouse is six, wherein female three, male three.
Preferably, water used in the S3 is distilled water.
Compared with prior art, practical the beneficial effects of the present invention are: preparation method of the invention is more scientific and reasonable
Property is more extensive, and preparation method step of the invention is simple, and raw material is cheap, reacts item when Fluconazole antibiotic is made by difluorobenzene
Part is more mild, is easier to realize, the fungicide produced through the invention has excellent bactericidal effect, and in mouse
When experiment in vivo, the lesser advantage of the toxicity shown.
Detailed description of the invention
Fig. 1 is flow chart of the invention.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
Embodiment one
The present invention provides a kind of technical solution: a kind of preparation method for sterilizing fungicide in spray with oneself, comprising the following steps:
S1: aminoglycoside antibiotics is prepared by oxygen bridge connection by amino sugar and aminocyclitol, is shifted using mutually catalysis
Technology is made Fluconazole antibiotic by difluorobenzene, produces antibiotic erythromycin by streptomysin；
S2: three obtained kind antibiotic in the extraction purification first step, and three kinds of antibiotic are mixed according to a certain percentage
Uniformly, mixture one is obtained；
S3: in parts by mass, including two parts of mixtures one, five parts of hydroxyl aluminium hydroxides, 15 parts of boric acid, 100 parts of water,
Obtain mixture two；
S4: specifically binding and carry out antibacterial effect test for mixture two obtained in S2 and golden yellow staphylococcus,
It the results are shown in Table 2；
S5: to mixture two obtained in step 3, the side that stomach-filling is passed through to three groups of female mices and three groups of male mices
Method carries out oxicity analysis, and the result is shown in tables 1.
Embodiment two
The present invention provides a kind of technical solution: a kind of preparation method for sterilizing fungicide in spray with oneself, comprising the following steps:
S1: aminoglycoside antibiotics is prepared by oxygen bridge connection by amino sugar and aminocyclitol, is shifted using mutually catalysis
Technology is made Fluconazole antibiotic by difluorobenzene, produces antibiotic erythromycin by streptomysin；
S2: three obtained kind antibiotic in the extraction purification first step, and three kinds of antibiotic are mixed according to a certain percentage
Uniformly, mixture one is obtained；
S3: in parts by mass, including two parts of mixtures one, five parts of hydroxyl aluminium hydroxides, 15 parts of boric acid, 100 parts of water,
Obtain mixture two；
S4: mixture two obtained in S2 and Escherichia coli are specifically bound and carry out antibacterial effect test, result
It is shown in Table 2；
Table 2
S5: carrying out oxicity analysis by the method to different intragastric administration on mice to mixture two obtained in step 3,
It the results are shown in Table 1.
Embodiment three
The present invention provides a kind of technical solution: a kind of preparation method for sterilizing fungicide in spray with oneself, comprising the following steps:
S1: aminoglycoside antibiotics is prepared by oxygen bridge connection by amino sugar and aminocyclitol, is shifted using mutually catalysis
Technology is made Fluconazole antibiotic by difluorobenzene, produces antibiotic erythromycin by streptomysin；
S2: three obtained kind antibiotic in the extraction purification first step, and three kinds of antibiotic are mixed according to a certain percentage
Uniformly, mixture one is obtained；
S3: in parts by mass, including two parts of mixtures one, five parts of hydroxyl aluminium hydroxides, 15 parts of boric acid, 100 parts of water,
Obtain mixture two；
S4: mixture two obtained in S2 and Candida albicans are specifically bound and is carried out antibacterial effect test, is tied
Fruit is shown in Table 2；
S5: carrying out oxicity analysis by the method to different intragastric administration on mice to mixture two obtained in step 3,
It the results are shown in Table 1.
Table 1
By comparing experiment to above-mentioned three groups of embodiments, there is fungicide prepared by the present invention excellent sterilization to imitate
Fruit, wherein all having preferable bactericidal effect, preparation of the invention to staphylococcus aureus, Escherichia coli, Candida albicans
Method is more scientific and reasonable, can reduce production cost, and preparation method step of the invention is simple, produces fluorine health by difluorobenzene
Reaction condition is more mild when azoles antibiotic, more energy saving in process of production, the fungicide produced through the invention,
Show have the advantages that sterilization antibacterial effect is excellent in sterilization antibacterial test, when carrying out toxotest in Mice Body, performance
Toxicity out is smaller, and reaction condition is more mildly easier to realize.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (8)
1. the preparation method of fungicide in a kind of sterilization spray with oneself, which comprises the following steps:
S1: preparing aminoglycoside antibiotics by oxygen bridge connection by amino sugar and aminocyclitol, using being mutually catalyzed transfer techniques,
Fluconazole antibiotic is made by difluorobenzene, antibiotic erythromycin is produced by streptomysin；
S2: three obtained kind antibiotic in the extraction purification first step, and three kinds of antibiotic are uniformly mixed according to a certain percentage,
Obtain mixture one；
S3: in parts by mass, including two parts of mixtures one, five parts of hydroxyl aluminium hydroxides, 15 parts of boric acid, 100 parts of water obtain
Mixture two；
S4: mixture two obtained in S2 is specifically bound simultaneously with golden yellow staphylococcus, Escherichia coli, Candida albicans respectively
Carry out antibacterial effect test；
S5: oxicity analysis is carried out by the method to different intragastric administration on mice to mixture two obtained in step 3.
2. the preparation method of fungicide in a kind of sterilization as described in claim 1 spray with oneself, it is characterised in that: the mixture
Mixed proportion be (1-2) part aminoglycoside antibiotics: (1-2) part Fluconazole antibiotic: (1-2) part antibiotic erythromycin.
3. the preparation method of fungicide in one kind sterilization as described in claim 1 spray with oneself, it is characterised in that: the extraction is pure
The method of change has chromatographic column method, chromatography and centrifugal process etc..
4. the preparation method of fungicide in a kind of sterilization as described in claim 1 spray with oneself, it is characterised in that: described this method
The method of the extraction purification used is chromatography.
5. the preparation method of fungicide in a kind of sterilization as described in claim 1 spray with oneself, it is characterised in that: in the S5
Test method is succusion.
6. the preparation method of fungicide in a kind of sterilization as described in claim 1 spray with oneself, it is characterised in that: the mouse is equal
For health, just grow up, be not used, female does not produce and without pregnant, the weight of mouse is 18-22g, and individual mesosome heavy phase difference does not surpass
Cross the 20% of average weight.
7. the preparation method of fungicide in a kind of sterilization as described in claim 1 spray with oneself, it is characterised in that: the mouse
Quantity is six, wherein female three, male three.
8. the preparation method of fungicide in a kind of sterilization as described in claim 1 spray with oneself, it is characterised in that: institute in the S3
The water used is distilled water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811401289.2A CN109172591A (en) | 2018-11-22 | 2018-11-22 | A kind of preparation method for sterilizing fungicide in spray with oneself |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811401289.2A CN109172591A (en) | 2018-11-22 | 2018-11-22 | A kind of preparation method for sterilizing fungicide in spray with oneself |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109172591A true CN109172591A (en) | 2019-01-11 |
Family
ID=64938137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811401289.2A Pending CN109172591A (en) | 2018-11-22 | 2018-11-22 | A kind of preparation method for sterilizing fungicide in spray with oneself |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109172591A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040208842A1 (en) * | 2001-09-18 | 2004-10-21 | Ritchie Branson W. | Antimicrobial cleansing compositions and methods of use |
| CN101396363A (en) * | 2007-09-28 | 2009-04-01 | 重庆医药工业研究院有限责任公司 | Composite antibacterial drugs composition containing abafungin |
-
2018
- 2018-11-22 CN CN201811401289.2A patent/CN109172591A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040208842A1 (en) * | 2001-09-18 | 2004-10-21 | Ritchie Branson W. | Antimicrobial cleansing compositions and methods of use |
| CN101396363A (en) * | 2007-09-28 | 2009-04-01 | 重庆医药工业研究院有限责任公司 | Composite antibacterial drugs composition containing abafungin |
Non-Patent Citations (2)
| Title |
|---|
| SERVAIS, H等: "Stability and compatibility of ceftazidime administered by continuous infusion to intensive care patients", 《ANTIMICROBIAL AGENTS AND CHEMOTHERAPY》 * |
| 陈勇等主编: "《药：千错万错别吃错》", 31 May 2016, 中国协和医科大学出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103125779B (en) | A kind of broiler chicken biological Chinese herbal medicine feed addictive and preparation method thereof | |
| CN104000014B (en) | A kind of alternative antibiotic feed addictive and preparation method thereof and application | |
| CN101829082B (en) | Method for preparing veterinary injection of spectinomycin hydrochloride and lincomycin hydrochloride | |
| CN103127196A (en) | Preparation method and application of total extractive of artemisia rupestris L | |
| CN103555225B (en) | A kind of preparation method of Silver ion anti-bacterial glue | |
| CN109172591A (en) | A kind of preparation method for sterilizing fungicide in spray with oneself | |
| CN103083510A (en) | Chinese medicinal oral liquid for improving poultry immune function and its preparation method | |
| CN104147076A (en) | Lonicera japonica antibacterial agent for restraining micrococcus luteus | |
| CN102895378B (en) | Pharmaceutical compound preparation for treating livestock respiratory diseases and method for preparing pharmaceutical compound preparation for treating livestock respiratory diseases | |
| CN103550226B (en) | Compound sulfamonomethoxine sodium injection as well as preparation method thereof | |
| CN105566262A (en) | Benzofuran-7-alkylamine compounds and applications thereof | |
| CN1257715C (en) | Clindamycin metronidazole vagina effervescent tablet and its preparing method and use | |
| CN104546967A (en) | Composite venenum bufonis injection and preparation method thereof | |
| CN107875154B (en) | Composition containing piperacillin, pharmaceutical preparation and application thereof | |
| CN111658605A (en) | Saimiqili solution preparation and preparation method thereof | |
| CN106589076A (en) | Centrosymmetric alpha helix peptide, preparation method and application thereof | |
| CN102895377B (en) | Pharmaceutical composition for treating livestock respiratory diseases and method for preparing pharmaceutical composition for treating livestock respiratory diseases | |
| CN111511368B (en) | Composition containing piperacillin sodium and sulbactam sodium for treating drug-resistant acinetobacter baumanii infection | |
| CN102895379B (en) | Pharmaceutical preparation for treating livestock respiratory diseases and method for preparing pharmaceutical preparation for treating livestock respiratory diseases | |
| CN101780064B (en) | New application of p-hydroxyl cinnamic acid | |
| CN102091321A (en) | Medicament oral liquid for treating enteritis and diarrhea and preparation method thereof | |
| RU2396083C1 (en) | Method for making complex preparation for prevention and treatment of diseases in animals | |
| CN111053893A (en) | Antibacterial effervescent tablet and preparation method thereof | |
| CN104056595B (en) | A kind of algae and water toxin degradation element | |
| CN106667994A (en) | Application of oligomeric polyphenol compounds to preparation of gram-positive drug-resistant bacterium resistant products |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190111 |