CN109172522A - 银杏叶口服微乳及其制备方法 - Google Patents

银杏叶口服微乳及其制备方法 Download PDF

Info

Publication number
CN109172522A
CN109172522A CN201811291399.8A CN201811291399A CN109172522A CN 109172522 A CN109172522 A CN 109172522A CN 201811291399 A CN201811291399 A CN 201811291399A CN 109172522 A CN109172522 A CN 109172522A
Authority
CN
China
Prior art keywords
spare
microemulsion
taken
ginkgo biloba
stirred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201811291399.8A
Other languages
English (en)
Inventor
宋育刚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guizhou Four Seasons Fruitful Agricultural Development Co Ltd
Original Assignee
Guizhou Four Seasons Fruitful Agricultural Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guizhou Four Seasons Fruitful Agricultural Development Co Ltd filed Critical Guizhou Four Seasons Fruitful Agricultural Development Co Ltd
Priority to CN201811291399.8A priority Critical patent/CN109172522A/zh
Publication of CN109172522A publication Critical patent/CN109172522A/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

本发明公开了一种银杏叶口服微乳，其各组分的重量百分比为：银杏总黄酮醇苷：24％～60％，按银杏叶提取物干燥品计；萜类内酯：6％～15％，按银杏叶提取物干燥品计；总银杏酸：0～10ppm；吐温‑80：0％～5％；甘油：0％～5％；木糖醇：0％～5％；维生素C：0％～2％；海藻酸钠：0％～3％；制备方法：取乳化剂、助乳化剂，搅拌混合，制得(I)，备用；取银杏叶提取物，与(I)搅拌混合，使均匀，制得(II)，备用；取调味剂、抗氧化剂、增稠剂，用去离子水溶解，制得(III)，备用；将(III)缓慢加入(II)中，边加边搅拌混合微乳化，过滤制得微乳液(IV)，备用；微乳液(IV)经检查合格后，罐装，加塞，压盖；灭菌即得。

Description

银杏叶口服微乳及其制备方法
技术领域
本发明涉及一种微乳形式的银杏叶口服微乳及其制备方法。
背景技术
现代药理研究表明，银杏叶提取物具有抗血小板激活因子的作用，可降低血液粘稠度与红细胞聚集，改变血液的流动性；可增强心肌缺血预适应，改善冠脉循环；并具有抗自由基，提高机体免疫功能等作用。银杏叶提取物的剂型较多，有片剂、胶囊剂、软胶囊剂、注射剂、颗粒剂、口服液等。由于银杏叶提取物难溶于水，口味极苦，因此，口服液中含有15～20％乙醇和30％左右的蔗糖，但仍然存在口味极苦、辛辣、患者难于服用之不足。微乳化技术是指将油、水、乳化剂和助乳化剂按一定比例，在一定温度下，通过适当方法混合成外观透明的胶体分散系统的技术。微乳用作药物的胶体性载体，它的特点是增大水难溶性药物溶解性，提高易水解药物的稳定性，掩盖药物的不良口味，也可作为缓释或靶向给药的制剂。
发明内容
针对上述银杏叶口服液的缺陷，本发明的主要目的在于提供一种不含乙醇的微乳形式的银杏叶口服微乳，其不仅不含乙醇和蔗糖，口味较好，外观透明，性质稳定，制备方便，而且具有更好的疗效。
为了实现上述目的，本发明的技术方案如下：
一种银杏叶口服微乳，各组分含量是：银杏总黄酮醇苷：24％～60％，按银杏叶提取物干燥品计；萜类内酯：6％～15％，按银杏叶提取物干燥品计；总银杏酸：0～10ppm；吐温-80：0％～5％；甘油：0％～5％；木糖醇：0％～5％；维生素C：0％～2％；海藻酸钠：0％～3％；按如下步骤制备：
(1)取乳化剂、助乳化剂，搅拌混合，制得(I)，备用；
(2)取银杏叶提取物，与(I)搅拌混合，使均匀，制得(II)，备用；
(3)取调味剂、抗氧化剂、增稠剂，用去离子水溶解，制得(III)，备用；
(4)将(III)缓慢加入(II)中，边加边搅拌混合微乳化，过滤制得微乳液(IV)，备用；
(5)微乳液(IV)经检查合格后，罐装，加塞，压盖；
(6)100～121℃热压灭菌10～60分钟即得。
本发明不含乙醇和蔗糖，口味较好，外观透明，性质稳定，制备方便，而且具有更好的疗效。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1：各组分含量是：银杏总黄酮醇苷：24％～60％，按银杏叶提取物干燥品计；萜类内酯：6％～15％，按银杏叶提取物干燥品计；总银杏酸：0～10ppm；吐温-80：0％～5％；甘油：0％～5％；木糖醇：0％～5％；维生素C：0％～2％；海藻酸钠：0％～3％；按如下步骤制备：
(1)取乳化剂、助乳化剂，搅拌混合，制得(I)，备用；
(2)取银杏叶提取物，与(I)搅拌混合，使均匀，制得(II)，备用；
(3)取调味剂、抗氧化剂、增稠剂，用去离子水溶解，制得(III)，备用；
(4)将(III)缓慢加入(II)中，边加边搅拌混合微乳化，过滤制得微乳液(IV)，备用；
(5)微乳液(IV)经检查合格后，罐装，加塞，压盖；
(6)100～121℃热压灭菌10～60分钟即得。

Claims (1)

1.一种银杏叶口服微乳，其特征是各组分含量是：银杏总黄酮醇苷：24％～60％，按银杏叶提取物干燥品计；萜类内酯：6％～15％，按银杏叶提取物干燥品计；总银杏酸：0～10ppm；吐温-80：0％～5％；甘油：0％～5％；木糖醇：0％～5％；维生素C：0％～2％；海藻酸钠：0％～3％；按如下步骤制备：
(1)取乳化剂、助乳化剂，搅拌混合，制得(I)，备用；
(2)取银杏叶提取物，与(I)搅拌混合，使均匀，制得(II)，备用；
(3)取调味剂、抗氧化剂、增稠剂，用去离子水溶解，制得(III)，备用；
(4)将(III)缓慢加入(II)中，边加边搅拌混合微乳化，过滤制得微乳液(IV)，备用；
(5)微乳液(IV)经检查合格后，罐装，加塞，压盖；
(6)100～121℃热压灭菌10～60分钟即得。
CN201811291399.8A 2018-10-31 2018-10-31 银杏叶口服微乳及其制备方法 Withdrawn CN109172522A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811291399.8A CN109172522A (zh) 2018-10-31 2018-10-31 银杏叶口服微乳及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811291399.8A CN109172522A (zh) 2018-10-31 2018-10-31 银杏叶口服微乳及其制备方法

Publications (1)

Publication Number Publication Date
CN109172522A true CN109172522A (zh) 2019-01-11

Family

ID=64941311

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811291399.8A Withdrawn CN109172522A (zh) 2018-10-31 2018-10-31 银杏叶口服微乳及其制备方法

Country Status (1)

Country Link
CN (1) CN109172522A (zh)

Similar Documents

Publication Publication Date Title
Tandi et al. Effect of ethanol extract from purple eggplant skin (Solanum melongena L) on blood glucose levels and pancreatic Β cells regeneration on white rats male hypercholesterolemia-diabetic
CN109464418A (zh) 一种维生素c维生素e软胶囊及其制备方法
CN103156193A (zh) 一种辅酶q10软胶囊及其制备方法
CN102440928A (zh) 具有促进皮肤微循环功效的中药组合物、制剂及其制备方法
RU2516932C2 (ru) Биологически активная добавка к пище, обладающая гепатопротекторными и иммуностимулирующими свойствами
CN107307390A (zh) 功能营养强化剂组合物及制备方法
CN107412440B (zh) 一种复方红衣补血口服液及其质量检测方法
CN102293820B (zh) 一种中药组合物在制备减少心肌梗死后患者死亡事件的药物中的应用
CN108741080A (zh) 一种微藻dha-花青素双相纳米脂质体及其制备方法
CN107296278A (zh) 一种功能营养强化剂组合物及其制备方法
CN103816086B (zh) 一种中药美白组合物及制备方法及应用
CN109172522A (zh) 银杏叶口服微乳及其制备方法
CN105348375A (zh) 一种茶籽糖蛋白及其制备方法与应用
CN101492489B (zh) 银莲花素a的提取方法及其脂微球制剂的制备方法
CN104352427A (zh) 一种含有穿心莲内酯的药物组合物及其用途
CN100417389C (zh) 一种用于治疗微血管循环障碍疾病的药物组合物及其制备方法
CN1951404A (zh) 银杏叶口服微乳及其制备方法
Campuzano-Bublitz et al. Acute and chronic anti-hyperglycemic effect of Prosopis ruscifolia extract in normoglycemic and alloxan-induced hyperglycemic rats
WO2008069604A1 (en) Composition comprising the mixed herbal extract of aralia cordata thunb. and cimicifuga heracleifolia kom. for preventing and treating inflammatory disease and pain disease
JP2009143838A (ja) 筋肉活性化剤
CN104945525B (zh) 黄刺果实多糖及其制备方法和用途
CN103599337B (zh) 大蒜皂苷脂质体及其制备方法
CN103804392B (zh) 两种三联苯并二恶嗪衍生物及其应用
KR20210117961A (ko) 우장지의 숙취 해소 및 알코올 대사 증가 용도
CN1615971B (zh) 醒脑静注射乳剂及其制备方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20190111

WW01 Invention patent application withdrawn after publication