CN109170852A - Fluffy ferment oral solution of a kind of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy and preparation method thereof - Google Patents
Fluffy ferment oral solution of a kind of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy and preparation method thereof Download PDFInfo
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- CN109170852A CN109170852A CN201811026988.3A CN201811026988A CN109170852A CN 109170852 A CN109170852 A CN 109170852A CN 201811026988 A CN201811026988 A CN 201811026988A CN 109170852 A CN109170852 A CN 109170852A
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- alkali
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- 150000002212 flavone derivatives Chemical class 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- 150000002216 flavonol derivatives Chemical class 0.000 description 1
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- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
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- 230000002218 hypoglycaemic effect Effects 0.000 description 1
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- 230000006872 improvement Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
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- 235000008696 isoflavones Nutrition 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- DDELFAUOHDSZJL-UHFFFAOYSA-N kaempferol 3-O-rutinoside-7-O-rhamnoside Natural products OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(CO)OC1OC1=C(C=2C=CC(O)=CC=2)OC2=CC(OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C1=O DDELFAUOHDSZJL-UHFFFAOYSA-N 0.000 description 1
- PEFASEPMJYRQBW-UHFFFAOYSA-N kaempferol 7-O-alpha-L-rhamnopyradoside 3-O-beta-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(OC4C(C(O)C(O)C(C)O4)O)C=C3OC=2C=2C=CC(O)=CC=2)=O)O1 PEFASEPMJYRQBW-UHFFFAOYSA-N 0.000 description 1
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- 230000037356 lipid metabolism Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 239000002636 mycotoxin Substances 0.000 description 1
- 210000000066 myeloid cell Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- VNONINPVFQTJOC-UHFFFAOYSA-N polyphyllin III Natural products O1C2(OCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC(C(C1O)OC2C(C(O)C(O)C(C)O2)O)OC(CO)C1OC1OC(C)C(O)C(O)C1O VNONINPVFQTJOC-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- PEFASEPMJYRQBW-XMWKPCQISA-N robinin Natural products O(C[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](OC2=C(c3ccc(O)cc3)Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@@H](O)[C@@H](C)O4)c3)C2=O)O1)[C@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 PEFASEPMJYRQBW-XMWKPCQISA-N 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
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- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
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- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to ferment oral solution technical fields, nutritive validity to keep alkali fluffy is adequately developed, disclose a kind of fluffy ferment oral solution of the alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy and preparation method thereof, the fluffy ferment oral solution of the alkali is by with the fluffy grass of alkali, for major ingredient, pueraria lobata, Poria cocos, chrysanthemum, cassia seed, safflower, Siraitia grosvenorii, hawthorn, gynostemma pentaphylla, lotus leaf, lemon, dendrobium nobile, fructus lycii, west safflower, STEVIA REBAUDIANA, Chinese yam, fructus cannabis, black rice, pepper and shredded ginger are that auxiliary material is made through depth fermentation.For ferment oral solution of the invention with the fluffy grass of alkali for major ingredient, pueraria lobata etc. is auxiliary material, mixes each material effective component uniformly and mutually cooperates with, have reduce blood pressure, blood lipid, blood glucose and cholesterol, and have the effect of anti-oxidant, anti-aging.Sufficiently remove the alkali astringent taste of the fluffy grass of alkali and the parch taste of cassia seed, fructus cannabis, the basic alkali-free astringent taste of obtained ferment oral solution during the preparation process simultaneously, and antioxidant activity is high.
Description
Technical field
The present invention relates to ferment oral solution technical fields, and in particular to a kind of fluffy ferment of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy
Plain oral solution and preparation method thereof.
Background technique
The fluffy grass of alkali is annual herb salification plant, is mainly grown on the saline-alkali wasteland at beach, lakeside, desert etc., is
Typical salt-soda soil indicator plant not only has significant application value in improvement saline-alkali environment, but also the fluffy grass of alkali is full of nutrition,
Vitamin, minerals, carbohydrate and fat abundant containing needed by human body, protein etc. have important nutritive value.
But since the fluffy careless growing environment of alkali is special, and alkali astringent taste is had, therefore be not valued by people and rationally utilize.In recent years
Come going deep into wild plant resource developmental research, the development and utilization of people's grass fluffy to alkali are just gradually risen, but mostly with young stem and leaf
As green vegetables based on edible, the fluffy seed Linoleic acid of alkali extraction etc..Though having at present fluffy for raw material preparation solution with alkali on a small quantity
The research of body health drink, but it is not deep enough, and the fluffy possessed nutrition and health care effect of alkali fails adequately to be developed.
Chinese patent CN105029632B, a kind of Suaeda salsa fermented beverage of patent name and preparation method thereof, the applying date
December 8 2017 phase, disclose it is a kind of by from the stem and leaf of Suaeda salsa separation and Extraction chlorophyl liquid prepare the fluffy juice of alkali
The method that fermented by mixed bacterium obtains fermented beverage is added in liquid after then mixing with plain chocolate, sucrose, watermelon juice, this method
The fluffy utilization rate of alkali is low, and the fluffy fermented beverage of alkali has a single function, while the fermented beverage prepared inevitably has alkali astringent taste.
Summary of the invention
For the problem that the fluffy fermented beverage research of current alkali is less, the fluffy nutritive validity of alkali is not fully developed, this hair
Bright is designed to provide a kind of fluffy ferment oral solution of the alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, is mixed with plurality of raw materials by alkali is fluffy
Depth fermentation makes the effective component of each raw material act on mutual cooperative reinforcing, and the fluffy nutritive validity of alkali is fully played.
Another object of the present invention is to provide a kind of fluffy ferment oral solutions of above-mentioned alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy
Preparation method, the fluffy alkali astringent taste of basic thoroughly removing alkali, and obtain each component in the fluffy ferment oral solution of alkali by depth fermentation
To sufficient reaction and cooperative reinforcing, the effect of alkali fluffy ferment oral solution, is higher.
The present invention provides the following technical solution:
A kind of fluffy ferment oral solution of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, the fluffy ferment oral solution of alkali is by based on the fluffy grass of alkali
Material, pueraria lobata, Poria cocos, chrysanthemum, cassia seed, safflower, Siraitia grosvenorii, hawthorn, gynostemma pentaphylla, lotus leaf, lemon, dendrobium nobile, fructus lycii, west safflower,
STEVIA REBAUDIANA, Chinese yam, fructus cannabis, black rice, pepper and shredded ginger, which are that auxiliary material is fermented, to be made.
As the preferred of the method for the present invention, each raw material mass mixture ratio for preparing the fluffy ferment oral solution of alkali is respectively parts by weight
Alkali is careless 45~60 parts fluffy, 10~15 parts of pueraria lobata, 8~13 parts of Poria cocos, 8~14 parts of chrysanthemum, 12~18 parts of cassia seed, safflower 8~12
Part, 12~16 parts of Siraitia grosvenorii, 8~12 parts of hawthorn, 8~12 parts of gynostemma pentaphylla, 12~16 parts of lotus leaf, 4~6 parts of lemon, dendrobium nobile 12~
14 parts, it is 10~15 parts of fructus lycii, 10~16 parts of west safflower, 12~16 parts of STEVIA REBAUDIANA, 6~10 parts of Chinese yam, 6~10 parts of fructus cannabis, black
10~15 parts of rice, 3~5 parts of pepper and 3~5 parts of shredded ginger.
The fluffy ferment oral solution of alkali of the invention is fluffy careless for major ingredient with alkali, pueraria lobata, Poria cocos, chrysanthemum, cassia seed, safflower, arhat
Fruit, hawthorn, gynostemma pentaphylla, lotus leaf, lemon, dendrobium nobile, fructus lycii, west safflower, STEVIA REBAUDIANA, Chinese yam, fructus cannabis, black rice, pepper and shredded ginger
Fermentation is made, and the nutriment of each component substantially completely enters in oral solution, and mutual cooperative reinforcing plays lower hyperlipidemia, hypertension, hyperglycemia and anti-aging
Effect, in which:
Alkali fluffy grass flavone compound rich in, including flavones, flavonols, flavanones and anthocyanidin etc., to unsaturated lipid
The oxidation of fat acid has stronger prevention effect, reaches anti-oxidant and delays senescence, and protects effect of cardiac muscle, while a large amount of in the fluffy grass of alkali
Human body necessary to the microelements, fatty linoleic acid such as amino acid, vitamin, carrotene and Ca, P, Fe, Cu, Zn, Mn, Se
With a- linolenic acid, helps to reduce blood pressure, blood lipid and cholesterol level, the master of anti-aging, blood pressure lowering, blood lipid and cholesterol is provided
Body effect.
Flavone compound rich in pueraria lobata, such as isoflavones Puerarin, peanut element, the work with reducing blood lipid
With Puerarin can also reduce blood glucose, enrich lower hyperlipidemia, hypertension, hyperglycemia effect of the fluffy grass of alkali；Lotus leaf is containing alkaloids, glycosides displayed, organic acid, energy
Serum cholesterol is reduced, and has effects that anti-oxidant and delays senescence, the antioxidation and reduction gallbladder of the fluffy grass of reinforced alkaline are solid
The effect of alcohol；Black rice contains the nutrients such as protein, B family vitamin, vitamin E and calcium, phosphorus, potassium, magnesium, iron, zinc, can be with
Free radical is removed, antioxidant effect is improved, the flavone compound contained simultaneously can maintain blood vessel normal osmotic pressure, mitigate blood vessel
Brittleness prevents angiorrhoxis and hemostasis, and improves myocardial nutrition, reduces myocardial oxygen consumption, reduces blood pressure, thus the fluffy grass of reinforced alkaline
Anti-oxidant and hypotensive activity；Chrysanthemum flavones ingredient rich in, such as Luteolin, apiolin and robinin and rich
Rich chrysanthemum glycosides, choline etc., can blood pressure lowering, coronary artery dilator and antibacterial, thus the hypotensive activity of the fluffy grass of reinforced alkaline.
Flavone compound, gynosaponin, gynostemma pentaphylla glucoside and water-soluble amino acids abundant, dimension life in gynostemma pentaphylla
Element, microelement play the role of anti-aging, anti-oxidant, promotion immunity, lowering blood pressure and blood fat and blood glucose；Contain in hawthorn
Flavone compound Vitex negundo var cannabifolia be known as the effect of anticancer, anti-aging, and flavone of hawthorn fruit can with reducing blood lipid, blood pressure and anti-oxidant,
And enhance the activity of red blood cell and Liver Superoxide Dismutase Activity (SOD)；The main body effect of the fluffy grass of reinforced alkaline.
The effect that the carboxymethyl pachymose that Poria cocos contains is improved immunity, reduces blood glucose；Safflower, west safflower can invigorate blood circulation
Cardiovascular system is protected in stagnation resolvation, anticoagulation, decompression；Dioscin in Chinese yam can blood pressure lowering, acceleration makes organism aging
The activity of enzyme significantly reduces, and delays senescence；Fructus cannabis contains linoleic acid, linolenic acid, can repair cardiac muscle, and blood pressure lowering reduces gallbladder
Sterol；Cassia seed can be depressured, reducing blood lipid, strengthen immunity；Polysaccharides in fructus lycii is able to ascend immune, removing freely
Base, antifatigue and anti-aging, glycine betaine then accelerate lipid-metabolism, and anti-fatty liver is formed；Vitamin C abundant and dimension in lemon
Raw element P can enhance blood vessel elasticity and toughness, can prevent and treat hypertension and myocardial infarction symptoms, reduce abnormal plasma glucose value, together
When lemon be high alka food, have very strong antioxidation, to promote skin metabolism, anti-aging and inhibition
Pigmentation etc. is largely effective；With the superoxide dismutase SOD of higher level in dendrobium nobile, lipid peroxide can be reduced
LPO, inhibit similar monoamine oxidase MAO, play the role of anti-aging, and immune work can be enhanced in contained dendrobium polysaccharide
Property and anti-aging, to cooperate with effect of flavone compound and amino acid, organic acid and vitamin etc. in ferment oral solution.
In the fluffy ferment oral solution of alkali of the invention in this way, the fluffy flavone compound rich in of alkali and mineral matter element,
Amino acid etc., the lowering blood pressure and blood fat and cholesterol of provider, anti-oxidant and function of delaying senility；Pueraria lobata, lotus leaf, black rice,
Chrysanthemum is because containing chromocor compound and a variety of glycoside compounds, effect of the fluffy grass of reinforced alkaline in terms of different, and it is abundant with it is complete
Kind the hypoglycemic of ferment oral solution, blood pressure lowering and effect for reducing blood fat；And the master of the fluffy grass of the more comprehensive reinforced alkaline of gynostemma pentaphylla, hawthorn
Body function；Poria cocos, safflower, west safflower, Chinese yam, fructus cannabis, cassia seed, fructus lycii, lemon and dendrobium nobile then cooperate in ferment oral solution
Chromocor compound abundant, further the effect of reinforcing ferment oral solution.But above-mentioned each component is based on cold, such as alkali
Fluffy, pueraria lobata, lotus leaf, chrysanthemum, gynostemma pentaphylla, cassia seed and dendrobium nobile etc., other be then it is mild-natured and, therefore make ferment take orally fluidity it is inclined
It is cool, it is not suitable for the cool crowd of stomach cold, stomach and drinks.And pepper can warm up stomach, be suitable for stomach cold crowd, shredded ginger can dispelling cold, clearing damp,
Warm stomach accelerates blood circulation, plays neutralization to the pharmacological property of each main component in ferment oral solution and ingredient.STEVIA REBAUDIANA, sieve
Sweet taste cellulose content is high in Chinese fruit, is suitable for hyperglycemia population, improves the mouthfeel of ferment oral solution.
A kind of preparation method of the fluffy ferment oral solution of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, comprising the following steps:
(1) select the fluffy grass of high-quality alkali, pueraria lobata, Poria cocos, chrysanthemum, cassia seed, safflower, Siraitia grosvenorii, hawthorn, gynostemma pentaphylla, lotus leaf,
Lemon, dendrobium nobile, fructus lycii, west safflower, STEVIA REBAUDIANA, Chinese yam, fructus cannabis, black rice, pepper and shredded ginger reject impurity, proportionally weigh
Sterile water wash is got well and used, is dried；
(2) each raw material is mashed into mixing, sterilizing respectively, is then charged into round, and microbe leaven mixing is added, then
It is sealed by fermentation after water is added；
(3) fermentor is placed in 30~35 DEG C primary fermentation 15~20 days in thermostatic chamber, uncapped daily stirring 2~3 times；
(4) round is transferred to Clean room after primary fermentation and obtains the fluffy ferment of alkali with the sterile sock filtration removing material residue of 150 purposes
Base-material；
(5) the fluffy ferment base-material of alkali is packed into clean round, sealing is placed in 6~12, old ferment in 25~30 DEG C of storage rooms
Month；
(6) fermented liquid for being finished old ferment with siphonage is sucked out, and filters off sediment, and filtrate sterilizes to obtain the fluffy ferment of alkali oral
Liquid.
Ferment oral liquor of the invention, will each raw material mix after first carry out primary fermentation, then old ferment again, makes
Such as esterification chemical reaction occurs between different application components, and makes the unfavorable ingredient volatilization in part, ferments to obtain by depth
Ferment oral solution in each component effect mutually cooperate with and close, and in good taste, uniform quality.
It is mashed again after following procedure is handled as the preferred of the method for the present invention, including by cassia seed, black rice and fructus cannabis
Mixing: the cassia seed, black rice and fructus cannabis of drying are mixed, and 3~5 times of total weight of water is added and dry yellow rice wine mixing is added, does
Yellow rice wine additional amount is 0.2~0.5L/L water, is kept for 20~25 DEG C, with 10~20min of ultrasonic treatment of 80~120W, then stirred
0.5~1.5h is impregnated, filtering is cleaned and the water boiling of 8~12 times of weight is added to 90~100 DEG C and keeps 1.5~2.5h, so
After be cooled to 28~38 DEG C of filterings, concentration filtrate volume to 30~40%, by filter residue drying grinding it is broken after merge with the filtrate being concentrated
For use.
Since the shell of cassia seed, black rice and fructus cannabis is harder, when fermentation is more difficult thoroughly to extract each effective component, therefore will
Its boiling comes out part effective component boiling, and direct fermentation is reacted, and is improved the utilizing status of effective component, is impregnated simultaneously
Boiling improves the hardness and permeability of shell, is utilized the residual component in cassia seed, black rice and fructus cannabis further.Certainly
Pine torch, fructus cannabis have unpleasant parch smell, this is the preparation process with cassia seed and fructus cannabis and generates, by it
It is placed in yellow rice wine-acetic acid and impregnates and apply ultrasonic wave added, enter this parch smell in solution and removed.Simultaneously in boiling
Cassia seed and the volatilization of the yellow rice wine on fructus cannabis surface in the process, and remaining parch smell are taken away, the filtered fluid that makes or
Concentrate removes this parch taste substantially.And contain a small amount of gill fungus toxin in fructus cannabis, enter in solvent in the case of ultrasonic wave added
It is hydrolyzed with acetic acidreaction, eliminates toxicity.
As the preferred of the method for the present invention, the fluffy grass of alkali mashes mixing again after following procedure is taken away the puckery taste: to 5~10wt% of concentration
Acetic acid solution in be added charcoal, be added after the fluffy grass of alkali and impregnate 2~5h in 30~35 DEG C of stirrings, the dosage of charcoal is 3
~7g charcoal/fluffy the grass of 50g alkali, the high-voltage electrostatic field for then applying 5~10KV handle 10~20min, and electric current is 5~7A.
The fluffy grass of alkali is grown on saline and alkaline beach, has stronger alkali puckery and bitter taste, is not suitable for direct drug injection.Method of the invention
It is middle the fluffy grass of alkali is cleaned up to be placed in acetic acid solution cooperate with high voltage electric field to take away the puckery taste processing, the alkali after acetic acid solution impregnates is fluffy
The most alkali salt on careless surface is dissolved in acetic acid solution and is adsorbed by charcoal, while the fluffy grass appearance of alkali is a degree of molten
Swollen, epidermal cell hole is dredged, and applying high-voltage electrostatic field keeps the point of cell wall and cell membrane chaotic, changes the logical of cell
Permeability strengthens the swelling effect of acetic acid, while acetic acid solution forms Ionization field under high voltage electrostatic field, accelerates alkali salt
Dissolution makes to be enriched in the fluffy careless surface layer of alkali and internal alkali salt and a small amount of polysaccharide is dissolved in acetic acid solution, and flavonoids active matter
Matter shows acid because containing a large amount of carboxyl, and the presence of acetic acid then inhibits the dissolution of Flavonoid substances, thus de- as far as possible
Except the alkali salt of the fluffy grass load of alkali, and the relative amount of Flavonoid substances in the fluffy grass of alkali is improved relatively.It is quiet by acetic acid and high pressure
The cooperative reinforcing of electric field effectively removes most alkali salt, and the alkali astringent taste of the fluffy grass of alkali significantly reduces, the fluffy grass of alkali after processing
Only slight alkali astringent taste.And high-voltage electrostatic field also has sterilization sterilization functions, and the fluffy grassland of alkali is made to expect to obtain sterilization treatment.This
The preferred preparation process of charcoal used in inventive method is as follows: bamboo powder is mixed with phenolic resin 1:0.4~0.6 in mass ratio
Uniformly, 500~600 DEG C of 3~5h of calcining in the oxygen barrier atmosphere of nitrogen are subsequently placed in and crushing obtains modified bamboo powdered carbon；By humin
Be dissolved in 3~5wt% sodium hydroxide solution, then add and be ultrasonically treated 15~25min after modified bamboo powdered carbon, humin with change
Property bamboo charcoal powder mass ratio be 1:0.4~0.7, then filtering and ethyl alcohol cleaning, re-dry obtains charcoal.Charcoal is by bamboo powder
Laden epoxy forms modified bamboo powdered carbon back loading humin and is made, and epoxy resin and bamboo powder form the friendship of interpenetrating after calcining
Networking network, generates more adsorption site and hole, is strengthened to the adsorption effect of the fluffy surface impurity of alkali and alkali salt, humin
Because being rich in hydroxyl and carboxyl, can be mutually complexed with the alkali salt being adsorbed, absorption of the enhanced biological charcoal to alkali salt, and humin is insoluble
It in acetic acid solution, washes with water and reuses after being desorbed, the stability of charcoal is strong.
As the preferred of the method for the present invention, step (2) microorganism used therefor leavening is Bacillus acidi lactici, Bifidobacterium, meter Qu
Mould, saccharomycete mixing liquid strain, Bacillus acidi lactici, Bifidobacterium, aspergillus oryzae and saccharomycete the mass ratio of liquid spawn be
1:1~3:1~3:1~5, the inoculum concentration of mixing liquid strain and the mass ratio of raw material gross weight are 1:13~17.Used in the present invention
Compounding strain is obtained through many experiments with optimization is groped by inventor, the battalion of gained ferment oral solution thorough to each raw material decomposes
It supports abundant.
As the preferred of the method for the present invention, amount of water is 10~30 times of raw material weight, water temperature 50~60 in step (2)
℃。
As the preferred of the method for the present invention, it is 7.5~8.3 that the pH value in round is kept in step (3).Due to sending out
There are a large amount of flavone compound, its inoxidizability and multiple biological activities to rely on phenyl ring more during ferment
Phenolic hydroxyl group, and the reactivity of this phenolic hydroxyl group is high, it is easy to the effect of being oxidized and reducing ferment oral solution, therefore in the early stage
It is 7.5~8.3 alkalescent that pH value is kept in fermentation process, ionizes phenolic hydroxyl group, so that phenolic hydroxyl group be protected to avoid being oxidized.
As the preferred of the method for the present invention, step (6) further includes the oligoisomaltose that 4~7wt% of weight is added to filtrate
With the sophorae honey of 1~5wt%.Improve the mouthfeel of ferment oral solution.
As the preferred of the method for the present invention, step (6) further includes that the fluffy ferment oral solution of resulting alkali is placed in 50~60MPa
Homogenization in high pressure sterile homogenizer.Each component is sufficiently mixed uniformly by homogeneous, is improved ferment oral solution performance and is stablized
Property.
Beneficial effects of the present invention are as follows:
For ferment oral solution of the invention with the fluffy grass of alkali for major ingredient, pueraria lobata etc. is auxiliary material, and each material effective component is made after everfermentation
Uniformly mix and mutually cooperate with, have reduce blood pressure, blood lipid, blood glucose and cholesterol, and the effect of anti-oxidant anti-aging.Together
When during the preparation process sufficiently remove the fluffy grass of alkali alkali astringent taste and cassia seed, fructus cannabis parch taste, obtained ferment oral solution
Basic alkali-free astringent taste, and antioxidant activity is high.
Specific embodiment
A specific embodiment of the invention is described further below.
Unless otherwise instructed, raw material employed in the present invention is commercially available or commonly used in the art, such as
Without special instruction, the method in following embodiments is the conventional method of this field.
Embodiment 1
The fluffy ferment oral solution of a kind of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, by the fluffy grass 45Kg of alkali, pueraria lobata 15Kg, Poria cocos 8Kg, chrysanthemum
Flower 14Kg, cassia seed 12Kg, safflower 8Kg, Siraitia grosvenorii 12Kg, hawthorn 10Kg, gynostemma pentaphylla 10Kg, lotus leaf 16Kg, lemon 4Kg, stone
Dry measure used in former times 12Kg, fructus lycii 10Kg, west safflower 10Kg, STEVIA REBAUDIANA 12Kg, Chinese yam 6Kg, fructus cannabis 6Kg, black rice 15Kg, pepper 3Kg and ginger
3Kg is fermented is made for silk.
The preparation method of the fluffy ferment oral solution of the above-mentioned alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, comprising the following steps:
(1) select the fluffy grass of high-quality alkali, pueraria lobata, Poria cocos, chrysanthemum, cassia seed, safflower, Siraitia grosvenorii, hawthorn, gynostemma pentaphylla, lotus leaf,
Lemon, dendrobium nobile, fructus lycii, west safflower, STEVIA REBAUDIANA, Chinese yam, fructus cannabis, black rice, pepper and shredded ginger reject impurity, proportionally weigh
Sterile water wash is got well and used, is dried；
(2) each raw material is mashed into mixing, sterilizing respectively, is then charged into round, and microbe leaven mixing is added, it is micro-
Bio-fermentation agent be Bacillus acidi lactici, Bifidobacterium, aspergillus oryzae, saccharomycete mixing liquid strain, Bacillus acidi lactici, Bifidobacterium,
The mass ratio of the liquid spawn of aspergillus oryzae and saccharomycete is 1:1:1:1, the inoculum concentration of mixing liquid strain and the matter of raw material gross weight
Amount is sealed by fermentation after adding 50 DEG C of water of 10 times of raw material weight than being 1:13；
(3) fermentor is placed in 30 DEG C primary fermentation 15 days in thermostatic chamber, keeping the pH value in round is 7.5, is opened daily
Lid stirring 2 times；
(4) round is transferred to Clean room after primary fermentation and obtains the fluffy ferment of alkali with the sterile sock filtration removing material residue of 150 purposes
Base-material；
(5) the fluffy ferment base-material of alkali is packed into clean round, sealing is placed in 25 DEG C of storage rooms old ferment 6 months；
(6) it is sucked out with the fermented liquid that siphonage finishes old ferment, and filters off sediment, the oligomeric of weight 1wt% is added to filtrate
The sophorae honey of isomaltose and 4wt%, then filtrate sterilizes to obtain the fluffy ferment oral solution of alkali, then equal in the high pressure sterile of 50MPa
Homogenization in matter machine, then Brown Glass Brown glass bottles and jars only is filling, capping.The anti-oxidant energy that the fluffy ferment oral solution of gained alkali is measured through FRAP method
Force value is 1.04mmol/50mL.
Wherein cassia seed, black rice and fructus cannabis mash mixing again after following procedure is handled: by the cassia seed of drying, black rice
It is mixed with fructus cannabis, 3 times of total weight of water is added and dry yellow rice wine and light-coloured vinegar mixing is added, dry yellow rice wine, light-coloured vinegar additional amount are respectively
0.2L/L water and 0.1L/ water, 20 DEG C of ultrasonic treatment 10min with 80W, then 0.5h is impregnated in stirring, and filtering is cleaned and is added 8 times
The water boiling of weight is to 90 DEG C and keeps 1.5h, is then cooled to 28 DEG C of filterings, and filtrate volume is concentrated to 30%, filter residue is dried
The broken rear filtrate with concentration is ground to merge for use.
The fluffy grass of alkali mashes mixing again after following procedure is taken away the puckery taste: charcoal, institute being added into the acetic acid solution of concentration 5wt%
It is the common bamboo charcoal implemented with charcoal, is added after the fluffy grass of alkali and impregnates 2h in 30 DEG C of stirrings, the dosage of charcoal is raw for 3g
Object charcoal/fluffy the grass of 50g alkali, the high-voltage electrostatic field for then applying 5KV handle 10min, electric current 7A.The fluffy grass of alkali after taking away the puckery taste is only light
Micro- alkali astringent taste.
Embodiment 2
A kind of fluffy ferment oral solution of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, difference from example 1 is that, the fluffy grass of alkali is de-
Charcoal through following procedure used in the process of puckery by being made:
Bamboo powder is uniformly mixed with phenolic resin 1:0.4 in mass ratio, is subsequently placed in 500 DEG C of calcining 5h in the oxygen barrier atmosphere of nitrogen
And it crushes and obtains modified bamboo powdered carbon；Humin is dissolved in 3wt% sodium hydroxide solution, is surpassed after then adding modified bamboo powdered carbon
The mass ratio of sonication 15min, humin and modified bamboo powdered carbon is that 1:0.4, then filtering and ethyl alcohol are cleaned, and re-dry is given birth to
Object charcoal.The basic alkali-free astringent taste of the fluffy grass of alkali after taking away the puckery taste.
Embodiment 3
A kind of fluffy ferment oral solution of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, by the fluffy grass 55Kg of alkali, pueraria lobata 13Kg, Poria cocos 11Kg,
Chrysanthemum 12Kg, cassia seed 15Kg, safflower 10Kg, Siraitia grosvenorii 13Kg, hawthorn 12Kg, gynostemma pentaphylla 12Kg, lotus leaf 14Kg, lemon 5Kg,
Dendrobium nobile 13Kg, fructus lycii 13Kg, west safflower 13Kg, STEVIA REBAUDIANA 14Kg, Chinese yam 8Kg, fructus cannabis 8Kg, black rice 13Kg, pepper 4Kg and
Shredded ginger 4Kg is fermented to be made.
The preparation method of the fluffy ferment oral solution of the above-mentioned alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, comprising the following steps:
(1) select the fluffy grass of high-quality alkali, pueraria lobata, Poria cocos, chrysanthemum, cassia seed, safflower, Siraitia grosvenorii, hawthorn, gynostemma pentaphylla, lotus leaf,
Lemon, dendrobium nobile, fructus lycii, west safflower, STEVIA REBAUDIANA, Chinese yam, fructus cannabis, black rice, pepper and shredded ginger reject impurity, proportionally weigh
Sterile water wash is got well and used, is dried；
(2) each raw material is mashed into mixing, sterilizing respectively, is then charged into round, and microbe leaven mixing is added, it is micro-
Bio-fermentation agent be Bacillus acidi lactici, Bifidobacterium, aspergillus oryzae, saccharomycete mixing liquid strain, Bacillus acidi lactici, Bifidobacterium,
The mass ratio of the liquid spawn of aspergillus oryzae and saccharomycete is 1:2:2:3, the inoculum concentration of mixing liquid strain and the matter of raw material gross weight
Amount is sealed by fermentation after adding 55 DEG C of water of 20 times of raw material weight than being 1:15；
(3) fermentor is placed in 33 DEG C primary fermentation 17 days in thermostatic chamber, keeping the pH value in round is 8.0, is opened daily
Lid stirring 2 times；
(4) round is transferred to Clean room after primary fermentation and obtains the fluffy ferment of alkali with the sterile sock filtration removing material residue of 150 purposes
Base-material；
(5) the fluffy ferment base-material of alkali is packed into clean round, sealing is placed in 28 DEG C of storage rooms old ferment 10 months；
(6) it is sucked out with the fermented liquid that siphonage finishes old ferment, and filters off sediment, the oligomeric of weight 4wt% is added to filtrate
The sophorae honey of isomaltose and 6wt%, then filtrate sterilizes to obtain the fluffy ferment oral solution of alkali, then equal in the high pressure sterile of 55MPa
Homogenization in matter machine, then Brown Glass Brown glass bottles and jars only is filling, capping.The anti-oxidant energy that the fluffy ferment oral solution of gained alkali is measured through FRAP method
Force value is 1.23mmol/50mL.
Wherein cassia seed, black rice and fructus cannabis mash mixing again after following procedure is handled: by the cassia seed of drying, black rice
It is mixed with fructus cannabis, 4 times of total weight of water is added and dry yellow rice wine and light-coloured vinegar mixing is added, dry yellow rice wine, light-coloured vinegar additional amount are respectively
0.4L/L water and 0.2L/ water, 23 DEG C of ultrasonic treatment 15min with 100W, then 1h is impregnated in stirring, and filtering is cleaned and is added 10 times
The water boiling of weight is to 95 DEG C and keeps 2h, is then cooled to 32 DEG C of filterings, and concentration filtrate volume to 35% grinds filter residue drying
It grinds and merges for use with the filtrate of concentration afterwards.
The fluffy grass of alkali mashes mixing again after following procedure is taken away the puckery taste: charcoal, institute being added into the acetic acid solution of concentration 7wt%
Be common commercially available bamboo charcoal with charcoal, be added after the fluffy grass of alkali and impregnate 4h in 32 DEG C of stirrings, charcoal dosage for 5g charcoal/
The fluffy grass of 50g alkali, the high-voltage electrostatic field for then applying 7KV handle 15min, electric current 6A.The fluffy grass of alkali after taking away the puckery taste is only slight
Alkali astringent taste.
Embodiment 4
A kind of fluffy ferment oral solution of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, the difference is that, the fluffy grass of alkali is de- with embodiment 3
Charcoal through following procedure used in the process of puckery by being made:
Bamboo powder is uniformly mixed with phenolic resin 1:0.5 in mass ratio, is subsequently placed in 550 DEG C of calcining 4h in the oxygen barrier atmosphere of nitrogen
And it crushes and obtains modified bamboo powdered carbon；Humin is dissolved in 4wt% sodium hydroxide solution, is surpassed after then adding modified bamboo powdered carbon
The mass ratio of sonication 20min, humin and modified bamboo powdered carbon is that 1:0.6, then filtering and ethyl alcohol are cleaned, and re-dry is given birth to
Object charcoal.The basic alkali-free astringent taste of the fluffy grass of alkali after taking away the puckery taste.
Embodiment 5
A kind of fluffy ferment oral solution of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, by the fluffy grass 60Kg of alkali, pueraria lobata 10Kg, Poria cocos 13Kg,
Chrysanthemum 8Kg, cassia seed 18Kg, safflower 12Kg, Siraitia grosvenorii 16Kg, hawthorn 8Kg, gynostemma pentaphylla 8Kg, lotus leaf 12Kg, lemon 6Kg, stone
Dry measure used in former times 14Kg, fructus lycii 15Kg, west safflower 16Kg, STEVIA REBAUDIANA 16Kg, Chinese yam 10Kg, fructus cannabis 10Kg, black rice 10Kg, pepper 5Kg and
Shredded ginger 5Kg is fermented to be made.
The preparation method of the fluffy ferment oral solution of the above-mentioned alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, comprising the following steps:
(1) select the fluffy grass of high-quality alkali, pueraria lobata, Poria cocos, chrysanthemum, cassia seed, safflower, Siraitia grosvenorii, hawthorn, gynostemma pentaphylla, lotus leaf,
Lemon, dendrobium nobile, fructus lycii, west safflower, STEVIA REBAUDIANA, Chinese yam, fructus cannabis, black rice, pepper and shredded ginger reject impurity, proportionally weigh
Sterile water wash is got well and used, is dried；
(2) each raw material is mashed into mixing, sterilizing respectively, is then charged into round, and microbe leaven mixing is added, it is micro-
Bio-fermentation agent be Bacillus acidi lactici, Bifidobacterium, aspergillus oryzae, saccharomycete mixing liquid strain, Bacillus acidi lactici, Bifidobacterium,
The mass ratio of the liquid spawn of aspergillus oryzae and saccharomycete is 1:3:3:5, the inoculum concentration of mixing liquid strain and the matter of raw material gross weight
Amount is sealed by fermentation after adding 60 DEG C of water of 30 times of raw material weight than being 1:17；
(3) fermentor is placed in 35 DEG C primary fermentation 20 days in thermostatic chamber, keeping the pH value in round is 8.3, is opened daily
Lid stirring 3 times；
(4) round is transferred to Clean room after primary fermentation and obtains the fluffy ferment of alkali with the sterile sock filtration removing material residue of 150 purposes
Base-material；
(5) the fluffy ferment base-material of alkali is packed into clean round, sealing is placed in 30 DEG C of storage rooms old ferment 12 months；
(6) it is sucked out with the fermented liquid that siphonage finishes old ferment, and filters off sediment, the oligomeric of weight 5wt% is added to filtrate
The sophorae honey of isomaltose and 7wt%, then filtrate sterilizes to obtain the fluffy ferment oral solution of alkali, then equal in the high pressure sterile of 60MPa
Homogenization in matter machine, then Brown Glass Brown glass bottles and jars only is filling, capping.The anti-oxidant energy that the fluffy ferment oral solution of gained alkali is measured through FRAP method
Force value is 1.15mmol/50mL.
Wherein cassia seed, black rice and fructus cannabis mash mixing again after following procedure is handled: by the cassia seed of drying, black rice
It is mixed with fructus cannabis, 5 times of total weight of water is added and dry yellow rice wine and light-coloured vinegar mixing is added, dry yellow rice wine, light-coloured vinegar additional amount are respectively
0.5L/L water and 0.3L/ water, 25 DEG C of ultrasonic treatment 20min with 120W, then 1.5h is impregnated in stirring, and filtering is cleaned and is added 12
The water boiling of times weight to 100 DEG C and keeps 2.5h, is then cooled to 38 DEG C of filterings, and filtrate volume is concentrated to 40%, filter residue is dried
Merge for use after dry grinding is broken with the filtrate of concentration.
The fluffy grass of alkali mashes mixing again after following procedure is taken away the puckery taste: charcoal, institute being added into the acetic acid solution of concentration 10wt%
It is commercially available common bamboo charcoal with charcoal, is added after the fluffy grass of alkali and impregnates 5h in 35 DEG C of stirrings, the dosage of charcoal is raw for 7g
Object charcoal/fluffy the grass of 50g alkali, the high-voltage electrostatic field for then applying 10KV handle 20min, electric current 5A.The fluffy grass of alkali after taking away the puckery taste is only
Slight alkali astringent taste.
Embodiment 6
A kind of fluffy ferment oral solution of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, the difference is that, the fluffy grass of alkali is de- with embodiment 5
Charcoal through following procedure used in the process of puckery by being made:
Bamboo powder is uniformly mixed with phenolic resin 1:0.6 in mass ratio, is subsequently placed in 600 DEG C of calcining 5h in the oxygen barrier atmosphere of nitrogen
And it crushes and obtains modified bamboo powdered carbon；Humin is dissolved in 5wt% sodium hydroxide solution, is surpassed after then adding modified bamboo powdered carbon
The mass ratio of sonication 25min, humin and modified bamboo powdered carbon is that 1:0.7, then filtering and ethyl alcohol are cleaned, and re-dry is given birth to
Object charcoal.The basic alkali-free astringent taste of the fluffy grass of alkali after taking away the puckery taste.
The chmice acute Oral toxicity test result of the fluffy ferment oral solution of alkali of the invention including above-described embodiment
Show that this Oral Liquid On Mice acute oral maximum tolerated dose is greater than high dose group 70mg/kgbw；Genetic toxicity test is small
Murine myeloid cells micronucleus test result is feminine gender, shows the fluffy ferment oral solution of the alkali without mutagenesis；By 35 days nursing rats
Test is it is found that the behavior of rat sign is normal, blood and blood parameters also variation without exception, therefore the agent of 70mg/kgbw
Amount (140 times of human body recommended amounts) belongs to safe dose；Genetic toxicity test and 35 days nursing rat test results are feminine gender,
It is thus determined that this health drink belongs to nontoxic based food, people can be with safe and secure edible.
Claims (10)
1. a kind of fluffy ferment oral solution of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, which is characterized in that the fluffy ferment oral solution of alkali
By fluffy careless for major ingredient, pueraria lobata, Poria cocos, chrysanthemum, cassia seed, safflower, Siraitia grosvenorii, hawthorn, gynostemma pentaphylla, lotus leaf, lemon, stone with alkali
Dry measure used in former times, fructus lycii, west safflower, STEVIA REBAUDIANA, Chinese yam, fructus cannabis, black rice, pepper and shredded ginger, which are that auxiliary material is fermented, to be made.
2. the fluffy ferment oral solution of the alkali according to claim 1 with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, which is characterized in that preparation
Each raw material mass mixture ratio of the fluffy ferment oral solution of alkali is respectively that the alkali of parts by weight is careless 45~60 parts fluffy, 10~15 parts of pueraria lobata, Poria cocos 8
~13 parts, 8~14 parts of chrysanthemum, 12~18 parts of cassia seed, 8~12 parts of safflower, 12~16 parts of Siraitia grosvenorii, 8~12 parts of hawthorn, strand
Blue 8~12 parts, 12~16 parts of lotus leaf, 4~6 parts of lemon, 12~14 parts of dendrobium nobile, 10~15 parts of fructus lycii, 10~16 parts of west safflower, sweet tea
12~16 parts of leaf chrysanthemum, 6~10 parts of Chinese yam, 6~10 parts of fructus cannabis, 10~15 parts of black rice, 3~5 parts of pepper and 3~5 parts of shredded ginger.
3. a kind of preparation method of the fluffy ferment oral solution of alkali with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy as claimed in claim 1 or 2,
Characterized by comprising the following steps:
(1) select the fluffy grass of high-quality alkali, pueraria lobata, Poria cocos, chrysanthemum, cassia seed, safflower, Siraitia grosvenorii, hawthorn, gynostemma pentaphylla, lotus leaf,
Lemon, dendrobium nobile, fructus lycii, west safflower, STEVIA REBAUDIANA, Chinese yam, fructus cannabis, black rice, pepper and shredded ginger reject impurity, proportionally weigh
Sterile water wash is got well and used, is dried；
(2) each raw material is mashed into mixing, sterilizing respectively, is then charged into round, and microbe leaven mixing is added, then
It is sealed by fermentation after water is added；
(3) fermentor is placed in 30~35 DEG C primary fermentation 15~20 days in thermostatic chamber, uncapped daily stirring 2~3 times；
(4) round is transferred to Clean room after primary fermentation and obtains the fluffy ferment of alkali with the sterile sock filtration removing material residue of 150 purposes
Base-material；
(5) the fluffy ferment base-material of alkali is packed into clean round, sealing is placed in 6~12, old ferment in 25~30 DEG C of storage rooms
Month；
(6) fermented liquid for being finished old ferment with siphonage is sucked out, and filters off sediment, and filtrate sterilizes to obtain the fluffy ferment of alkali oral
Liquid.
4. the preparation method of the fluffy ferment oral solution of the alkali according to claim 3 with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, special
Sign is, further includes that cassia seed, black rice and fructus cannabis are mashed mixing again after following procedure is handled: by the cassia seed of drying,
Black rice and fructus cannabis mixing are added 3~5 times of total weight of water and dry yellow rice wine and light-coloured vinegar mixing, dry yellow rice wine, light-coloured vinegar additional amount are added
Respectively 0.2~0.5L/L water and 0.1~0.3L/ water, 20~25 DEG C of 10~20min of ultrasonic treatment with 80~120W, then
0.5~1.5h is impregnated in stirring, and filtering clean and the water boiling of 8~12 times of weight is added to 90~100 DEG C and keeps 1.5~
2.5h, is then cooled to 28~38 DEG C of filterings, and concentration filtrate volume to 30~40% is broken rear and concentration by filter residue drying grinding
Filtrate merges stand-by.
5. the preparation method of the fluffy ferment oral solution of the alkali according to claim 3 with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy, special
Sign is that the fluffy grass of alkali mashes mixing again after following procedure is taken away the puckery taste: charcoal is added into the acetic acid solution of 5~10wt% of concentration,
It is added after the fluffy grass of alkali and impregnates 2~5h in 30~35 DEG C of stirrings, the dosage of charcoal is 3~7g charcoal/fluffy grass of 50g alkali, so
The high-voltage electrostatic field for applying 5~10KV afterwards handles 10~20min, and electric current is 5~7A.
6. the preparation side of the fluffy ferment oral solution of alkali according to claim 3 or 4 or 5 with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy
Method, which is characterized in that step (2) microorganism used therefor leavening is the mixing of Bacillus acidi lactici, Bifidobacterium, aspergillus oryzae, saccharomycete
Liquid spawn, Bacillus acidi lactici, Bifidobacterium, aspergillus oryzae and saccharomycete liquid spawn mass ratio be 1:1~3:1~3:1~
5, the inoculum concentration of mixing liquid strain and the mass ratio of raw material gross weight are 1:13~17.
7. the preparation side of the fluffy ferment oral solution of alkali according to claim 3 or 4 or 5 with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy
Method, which is characterized in that amount of water is 10~30 times, 50~60 DEG C of water temperature of raw material weight in step (2).
8. the preparation side of the fluffy ferment oral solution of alkali according to claim 3 or 4 or 5 with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy
Method, which is characterized in that it is 7.5~8.3 that the pH value in round is kept in step (3).
9. the preparation side of the fluffy ferment oral solution of alkali according to claim 3 or 4 or 5 with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy
Method, which is characterized in that step (6) further includes the sophora flower that the oligoisomaltose and 4~7wt% of 1~5wt% of weight are added to filtrate
Honey.
10. the preparation side of the fluffy ferment oral solution of alkali according to claim 3 or 4 or 5 with lower hyperlipidemia, hypertension, hyperglycemia senile-resistant efficacy
Method, which is characterized in that step (6) further includes that the fluffy ferment oral solution of resulting alkali is placed in 50~60MPa high pressure sterile homogenizer
Middle homogenization.
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Application publication date: 20190111 |