CN109152823A - 用于癌症治疗的酶原的组合物 - Google Patents
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- CN109152823A CN109152823A CN201780021479.9A CN201780021479A CN109152823A CN 109152823 A CN109152823 A CN 109152823A CN 201780021479 A CN201780021479 A CN 201780021479A CN 109152823 A CN109152823 A CN 109152823A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21001—Chymotrypsin (3.4.21.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201662321370P | 2016-04-12 | 2016-04-12 | |
| US62/321,370 | 2016-04-12 | ||
| PCT/AU2017/050323 WO2017177270A1 (en) | 2016-04-12 | 2017-04-12 | Composition of proenzymes for cancer treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109152823A true CN109152823A (zh) | 2019-01-04 |
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| EP (1) | EP3442564B1 (enExample) |
| JP (1) | JP7004665B2 (enExample) |
| CN (1) | CN109152823A (enExample) |
| AU (1) | AU2017250010A1 (enExample) |
| WO (1) | WO2017177270A1 (enExample) |
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| MY196737A (en) * | 2015-11-12 | 2023-05-03 | Propanc Pty Ltd | Proenzyme composition |
| US12419938B2 (en) | 2015-11-12 | 2025-09-23 | Propanc Pty Ltd | Proenzyme composition |
| IL260814B2 (en) | 2016-01-29 | 2023-04-01 | Propanc Pty Ltd | Cancer treatment |
| EP3641800B1 (en) * | 2017-06-22 | 2023-10-04 | CSL Behring Lengnau AG | Modulation of fviii immunogenicity by truncated vwf |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011047434A1 (en) * | 2009-10-22 | 2011-04-28 | Propanc Pty Ltd | A pharmaceutical composition for treating cancer comprising trypsinogen and/or chymotrypsinogen and an active agent selected from a selenium compound, a vanilloid compound and a cytoplasmic glycolysis reduction agent |
| WO2015070828A1 (en) * | 2013-11-18 | 2015-05-21 | Frantisek Trnka | Pharmaceutical composition containing a mixture of proenzymes and enzymes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4514388A (en) * | 1983-03-22 | 1985-04-30 | Psaledakis Nicholas G | Proteolytic enzymes in the zymogen form to treat sarcoma cells |
| CZ283972B6 (cs) * | 1995-05-17 | 1998-07-15 | František Mudr. Trnka | Farmaceutický prostředek s modulačním účinkem na zhoubné nádory a jeho použití |
| IL260814B2 (en) * | 2016-01-29 | 2023-04-01 | Propanc Pty Ltd | Cancer treatment |
-
2017
- 2017-04-12 AU AU2017250010A patent/AU2017250010A1/en not_active Abandoned
- 2017-04-12 JP JP2018553345A patent/JP7004665B2/ja active Active
- 2017-04-12 CN CN201780021479.9A patent/CN109152823A/zh active Pending
- 2017-04-12 WO PCT/AU2017/050323 patent/WO2017177270A1/en not_active Ceased
- 2017-04-12 EP EP17781637.8A patent/EP3442564B1/en active Active
- 2017-04-12 US US16/094,846 patent/US20190134166A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011047434A1 (en) * | 2009-10-22 | 2011-04-28 | Propanc Pty Ltd | A pharmaceutical composition for treating cancer comprising trypsinogen and/or chymotrypsinogen and an active agent selected from a selenium compound, a vanilloid compound and a cytoplasmic glycolysis reduction agent |
| CN102639145A (zh) * | 2009-10-22 | 2012-08-15 | 普罗潘克股份有限公司 | 包含胰蛋白酶原和/或糜蛋白酶原和选自硒化合物，类香兰素化合物和细胞质糖酵解减少剂的活性剂的用于治疗癌的药物组合物 |
| WO2015070828A1 (en) * | 2013-11-18 | 2015-05-21 | Frantisek Trnka | Pharmaceutical composition containing a mixture of proenzymes and enzymes |
Non-Patent Citations (3)
| Title |
|---|
| KAISEROVA P等: "Proenzyme therapy of sarcoma s-180 and melanoma b16-f10", 《JOURNAL OF APPLIED BIOMEDICINE》 * |
| NOVAK J等: "Proenzyme therapy of cancer", 《ANTICANCER RESEARCH》 * |
| PERAN等: "Treatment of carcinoma cell lines with pancreatic (pro)enzymes suppresses the emt programme and promotes cell differentiation", 《CELLULAR ONCOLOGY》 * |
Also Published As
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|---|---|
| EP3442564B1 (en) | 2023-12-06 |
| EP3442564A4 (en) | 2019-12-04 |
| WO2017177270A1 (en) | 2017-10-19 |
| JP7004665B2 (ja) | 2022-02-04 |
| US20190134166A1 (en) | 2019-05-09 |
| EP3442564A1 (en) | 2019-02-20 |
| JP2019511525A (ja) | 2019-04-25 |
| AU2017250010A1 (en) | 2018-10-11 |
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