CN109147042A - A kind of customization design method of elbow joint brace - Google Patents
A kind of customization design method of elbow joint brace Download PDFInfo
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- CN109147042A CN109147042A CN201811131281.9A CN201811131281A CN109147042A CN 109147042 A CN109147042 A CN 109147042A CN 201811131281 A CN201811131281 A CN 201811131281A CN 109147042 A CN109147042 A CN 109147042A
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- 210000002310 elbow joint Anatomy 0.000 title claims abstract description 90
- 238000000034 method Methods 0.000 title claims abstract description 35
- 210000000245 forearm Anatomy 0.000 claims abstract description 52
- 210000000623 ulna Anatomy 0.000 claims abstract description 26
- 210000002758 humerus Anatomy 0.000 claims abstract description 18
- 210000002320 radius Anatomy 0.000 claims abstract description 18
- 230000006378 damage Effects 0.000 claims abstract description 12
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 11
- 208000014674 injury Diseases 0.000 claims abstract description 10
- 210000000707 wrist Anatomy 0.000 claims abstract description 5
- 238000010146 3D printing Methods 0.000 claims description 12
- 238000010008 shearing Methods 0.000 claims description 8
- 241000135309 Processus Species 0.000 claims description 6
- 230000010354 integration Effects 0.000 claims description 4
- 238000005259 measurement Methods 0.000 claims description 4
- 230000000452 restraining effect Effects 0.000 claims description 4
- 238000002224 dissection Methods 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 229910000838 Al alloy Inorganic materials 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 206010017076 Fracture Diseases 0.000 description 1
- 206010060820 Joint injury Diseases 0.000 description 1
- 208000005137 Joint instability Diseases 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 208000031294 Upper limb fractures Diseases 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000012938 design process Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T17/00—Three dimensional [3D] modelling, e.g. data description of 3D objects
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T19/00—Manipulating 3D models or images for computer graphics
- G06T19/20—Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
Abstract
A kind of customization design method of elbow joint brace, comprising steps of elbow joint brace customizes: the CT image based on the not injured arm of patient obtains the forearm brace model and large arm brace model of patient injury's arm by three-dimensional reconstruction；Elbow joint brace hinge design: forearm brace model corresponding to the three-dimensional space based on determined by ulna, humerus and radius and the three-dimensional space and large arm brace model, the hinge of design bridging forearm brace model and large arm brace model, and the cental axial position and angle of hinge are determined by ulna, humerus and radius；The design for guiding elbow joint brace to wear: in conjunction with the anatomical features point of ulna distal end wrist position and proximal ulna elbow joint position, design the location model that axial and circumferential positioning is carried out during wearing to elbow joint brace, so that the rotary shaft of hinge is overlapped with elbow joint real motion axis after elbow joint brace is worn.It can solve existing elbow joint brace by the elbow joint brace of customization and blindly wear generated rotary shaft mismatch problem.
Description
Technical field
The present invention relates to medical treatment and nursing appliance technologies, and in particular to a kind of customization design side of elbow joint brace
Method.
Background technique
Elbow joint brace is mainly used in the fixed protection of elbow joint soft tissue injury, and elbow fracture is fixed, elbow ligament damage
Situations such as wound fixation or Elbow joint instability, dislocation.Traditional elbow joint brace is mainly made of three parts, control forearm rotation
The hinge turned and the brace for fixing arm and its fixed bandage.Traditional elbow joint brace is in specifically used process
In, it is the subjectivity by people by traditional elbow joint brace wearing to the arm of patient, therefore, conventional wrist brace is not
Foot place is that the true elbow joint rotation axis of patient can not be positioned, and that is to say, when patient uses the brace, hinge
The axis of chain movement is not overlapped with the true axis of elbow joint.In the two there are when larger difference, not only cannot effectively assist
Patients ' recovery, it is also possible to cause patient to postpone rehabilitation, or even further damage elbow joint.
Summary of the invention
The application provides a kind of customization design method of elbow joint brace, comprising steps of
Elbow joint brace customizes: the CT image based on the not injured arm of patient obtains patient injury by three-dimensional reconstruction
The forearm brace model and large arm brace model of arm；
Elbow joint brace hinge design: the three-dimensional space based on determined by ulna, humerus and radius and three-dimensional space institute are right
The forearm brace model and large arm brace model answered, design bridge the hinge of the forearm brace model and large arm brace model,
And the cental axial position and angle of hinge are determined by the ulna, humerus and radius；
The design for guiding elbow joint brace to wear: in conjunction with ulna distal end wrist position and proximal ulna elbow joint position
Anatomical features point designs the location model that axial and circumferential positioning is carried out during wearing to elbow joint brace, so that elbow joint
After brace is worn, the rotary shaft of hinge is overlapped with elbow joint real motion axis.
In a kind of embodiment, specific steps that elbow joint brace customizes are as follows:
CT image mirrors are the CT image of patient injury's arm by the CT image for obtaining the not injured arm of patient；
The CT image of patient injury's arm is split and three-dimensional reconstruction algorithm is utilized to rebuild skin model, humerus mould
Type, ulna model and radius model；
Expansion process is carried out to skin model, obtains brace model；
Brace model is sheared using three-dimensional shearing function, obtains forearm brace model and large arm brace model.
In a kind of embodiment, the specific steps of elbow joint brace hinge design are as follows:
Under a certain revolution space state determined by humerus model, ulna model and radius model, to trochlea humeri into
Row cylinder fitting obtains fitting cylinder, and the central axis for being fitted cylinder is the true rotary shaft of elbow joint；
Hinge model is rebuild according to the measurement data of hinge under revolution space state, hinge model is connected across forearm brace
Between model and large arm brace model, and, the rotary shaft of hinge model and the center overlapping of axles of fitting cylinder.
In a kind of embodiment, the specific steps for the design that guidance elbow joint brace is worn are as follows:
The three-dimensional space based on determined by ulna, humerus and radius, design is according to processus styloideus ulnae on forearm brace model
The first location model positioned；
According to the determination position of the first location model and hinge under the three-dimensional space state, on forearm brace model
Design is advanced by leaps and bounds the second location model of row positioning according to olecroanon, and, processus styloideus ulnae and the are positioned to the first location model
Two location models be positioned at olecroanon it is prominent when, the rotary shaft of hinge model and the center overlapping of axles of fitting cylinder.
In a kind of embodiment, the first location model and the second location model are multi-stage telescopic model structure.
In a kind of embodiment, further includes the steps that shearing forearm brace model and large arm brace model, make forearm
Brace model and large arm brace model are cut into half opening formula.
In a kind of embodiment, further include the steps that designing air hole on forearm brace model and large arm brace model.
In a kind of embodiment, further include the steps that designing perforation on forearm brace model and large arm brace model, perforation
For wearing restraining.
In a kind of embodiment, the rotation angle adjustable of hinge.
It further include by the step of forearm brace model, large arm brace model and hinge integration 3D printing in a kind of embodiment
Suddenly.
Elbow joint brace according to above-described embodiment customizes design method, and the skin model based on patient creates personalized
Forearm brace model and large arm brace model, and design with the hinge of forearm brace model and large arm brace Model Matching, then
Axial and circumferential positioning is carried out to the process that elbow joint brace is worn by Design Orientation model, so that elbow joint brace used
Cheng Zhong, the rotary shaft and patient's elbow joint real motion overlapping of axles of hinge, to solve existing elbow joint brace, blindly wearing is produced
Raw rotary shaft mismatch problem.
Detailed description of the invention
Fig. 1 is that elbow joint brace customizes design flow diagram；
Fig. 2 is initial brace illustraton of model；
Fig. 3 is the brace illustraton of model after shearing；
Fig. 4 is that the brace after hinge and shearing cooperates schematic diagram；
Fig. 5 is the structural schematic diagram of elbow joint brace.
Specific embodiment
Below by specific embodiment combination attached drawing, invention is further described in detail.
In embodiments of the present invention, a kind of customization design method of elbow joint brace is provided, is designed by this method
Elbow joint brace not only has the characteristics that personalization, meanwhile, during the elbow joint brace of design is worn, elbow joint brace
The rotary shaft of hinge and elbow joint real motion axis are coaxial.
The flow chart of the customization design method of the elbow joint brace of this example is as shown in Figure 1, specifically comprise the following steps.
S1: elbow joint brace customizes.
In order to make the elbow joint brace of manufacture that there is personalization, needs to carry out CT tomoscan to patient, break to scanning
Layer image carries out skeleton character extraction, so that accurately personalized skeleton model is established, for elbow joint brace personalized designs
For, this example is that the forearm brace of patient injury's arm is obtained by three-dimensional reconstruction based on the CT image of the not injured arm of patient
Model and large arm brace model.
Specific step is:
1) CT image mirrors are the CT image of patient injury's arm by the CT image for obtaining the not injured arm of patient.
Because of situations such as the elbow joint injury of patient is broken in a organized way, bleeding, swelling even fracture, if directly utilization
The CT scan data of injured arm carries out three-dimensionalreconstruction, occurs very big dimensional discrepancy it will cause the threedimensional model of reconstruct.Cause
This, has the characteristics that symmetry, similitude, successional according to human body, passes through mirror-image fashion with injured complete side arm
Three-dimensional data replace the three-dimensional data at patient's hurt my arm position, can be avoided and directly reconstructed with the CT scan data in affected part
Threedimensional model and caused by deviation.
2) the CT image of patient injury's arm is split and three-dimensional reconstruction algorithm is utilized to rebuild skin model, humerus mould
Type, ulna model and radius model.
Such as, after carrying out Threshold segmentation to CT image, using Marching Cubes three-dimensional reconstruction algorithm, skin is obtained respectively
Threedimensional model, three dimensional model of humerus, ulna threedimensional model and radius threedimensional model.
3) expansion process is carried out to skin model, obtains brace model.
On the basis of the skin model that three-dimensional reconstruction obtains, by designing its outer encirclement skeleton pattern, initial branch is obtained
Has model, as shown in Figure 2.
It that is to say, on the skin image being partitioned by original CT image, expansion process, expansion are carried out based on pixel level
Value can be obtained according to CT image spacing and required outer profile THICKNESS CALCULATION, such as, it is assumed that the required thickness of outer profile be t, CT
Average headway be s, then swell value d=t/s.
4) brace model is sheared using three-dimensional shearing function, obtains forearm brace model and large arm brace model.
On initial brace model, using three-dimensional shearing function, continuous moulding is carried out to it, cuts off redundancy section,
The general shape for obtaining brace, provides basis for subsequent design, the brace model after shearing includes forearm brace model and large arm
Brace model, as shown in Figure 3.
Further, referring to the design of traditional brace, this step further include to forearm brace model and large arm brace model into
The step of finer trimming of row and adjustment, e.g., forearm brace model and large arm brace model are cut into half opening formula.
Further, in order to improve the overall air permeability of elbow joint brace, this step further includes in forearm brace model and big
The step of air hole is designed on arm brace model.
S2: elbow joint brace hinge design.
Hinge is the two-part component in large arm end and forearm end for connecting brace, and main function is auxiliary patient's forearm fortune
It is dynamic, guarantee that the axis of brace movement is hinge centerline, the main material of hinge is plastic material or aluminum alloy material, works as hinge
When for plastic material, the elbow joint brace of this example is made of 3D printing technique, that is to say, by forearm brace model, large arm branch
Have model and hinge integration 3D printing molding；When hinge is aluminum alloy material, then hinge is the conventional hinge of buying, and small
Arm brace model and large arm brace model are made up of 3D printing technique respectively, no matter hinge is made in which way, design hinge
When chain, forearm brace mould corresponding to three-dimensional space determined by ulna, humerus and radius and the three-dimensional space is comprehensively considered
Type and large arm brace model, in this case, the hinge of design and forearm brace model and large arm brace Model Matching, and should
The cental axial position and angle of hinge are determined by ulna, humerus and radius.
The process that hinge specifically designs is:
1) under a certain revolution space state determined by humerus model, ulna model and radius model, to trochlea humeri
It carries out cylinder fitting and obtains fitting cylinder, the central axis for being fitted cylinder is the true rotary shaft of elbow joint；
2) hinge model is rebuild according to the measurement data of hinge under revolution space state, hinge model is connected across forearm branch
Have between model and large arm brace model, and, the rotary shaft of hinge model and the center overlapping of axles of fitting cylinder.
Required hinge measurement data includes the diameter, thickness, hinge both ends of hinge when reconstructing hinge model in this step
Aluminum strip thickness, width and length and two strips between angle etc., hinge and forearm brace model and large arm
Brace model cooperates schematic diagram as shown in Figure 4.
Whether 3D printing hinge or conventional hinge is purchased, the hinge of this example has stable rotation center, and has
There is adjustable rotation angular interval.In specific design process, by adjusting the length and rotation angle of hinge strip, so that hinge
There is suitable size and Orientation after chain and forearm brace model and large arm brace Model Matching.
S3: the design that guidance elbow joint brace is worn.
This step is the committed step that the application elbow joint brace customizes design, by drawing to elbow joint brace wearing
It leads, realizes in elbow joint brace use process, the rotary shaft and patient's elbow joint real motion overlapping of axles of hinge, specifically, knot
The anatomical features point of ulna distal end wrist position and proximal ulna elbow joint position is closed, design wears process to elbow joint brace
The middle location model for carrying out axial and circumferential positioning, so that the rotary shaft and elbow joint of hinge are true after elbow joint brace is worn
Axis of movement is overlapped.
The step of this step specifically designs is:
1) three-dimensional space based on determined by ulna, humerus and radius, design is according to ulna stem on forearm brace model
The first location model that row of advancing by leaps and bounds positions.
2) the determination position according to the first location model and hinge under three-dimensional space state is set on forearm brace model
Meter according to olecroanon advance by leaps and bounds row positioning the second location model, and, be positioned at processus styloideus ulnae and second to the first location model
Location model be positioned at olecroanon it is prominent when, the rotary shaft of hinge model and the center overlapping of axles of fitting cylinder.
It should be noted that because of forearm, there are the movements of inward turning and outward turning, therefore there are many spatialities.Therefore, exist
Elbow joint brace is directed to a fixed position when designing, and the hinge axis of rotation only designed under this position is just revolved with dissection
Shaft alignment, so forearm a degree of can also exist circumferential when processus styloideus ulnae part to be aligned with the first location model
Rotation, wait rotate to the second location model and when olecroanon section aligned, the position of entire elbow joint brace just be can determine that
Get off, at this moment the rotary shaft of hinge and elbow joint real motion overlapping of axles, that is to say, the plane of hinge just can be with the rotation of dissection
Axis is mutually perpendicular to.
Overall beautiful for elbow joint brace, first location model and the second location model of this example are multi-stage expansion
Formula model structure, in other embodiments, the first location model and the second location model do not have Telescopic, but a certain solid
Measured length, therefore, those skilled in the art, can be according to the uniqueness of patient's arm feature, under design of the invention
One location model and the second location model are deformed, to achieve the purpose that guide the positioning of elbow joint brace to wear.
In the elbow joint brace use process of this example, in order to facilitate elbow joint brace and arm fixation, this example further include
The step of perforation is designed on forearm brace model and large arm brace model, which is used for lashing ligature, so that, elbow joint brace
It is fixed on arm by restraining.
Elbow joint brace can be customized through the above steps, which can use two kinds in specific manufacture
Method manufacture:
A kind of manufacturing method is: using 3D printing technique by forearm brace model, large arm brace model and hinge integration
3D printing molding；Another manufacturing method is: carrying out only with 3D printing technique to forearm brace model and large arm brace model
3D printing, and hinge is the conventional hinge of buying, and the hinge of buying is cut, by the forearm brace model of 3D printing and greatly
Hinge assemblies after arm brace model and processing.
Though using the elbow joint brace of which kind of manufacture manufacture, by taking 3D printing as an example, the whole knot of elbow joint brace
Composition is as shown in Figure 5.It first skids off the positioning draw runner of the first location model and its front end and ruler during wearing
The alignment of bone belemnoid, then rotates brace, and the positioning draw runner of the second location model is skidded off and prominent pair of its front end and olecroanon
Together, position the axial and circumferential of elbow joint brace all by the first location model and the second location model, so that elbow
The axis of movement of joint brace is overlapped with patient's elbow joint actual motion axis, is finally fixed elbow joint brace using restraining
In arm.
Use above specific case is illustrated the present invention, is merely used to help understand the present invention, not to limit
The system present invention.For those skilled in the art, according to the thought of the present invention, can also make several simple
It deduces, deform or replaces.
Claims (10)
1. a kind of customization design method of elbow joint brace, which is characterized in that comprising steps of
Elbow joint brace customizes: the CT image based on the not injured arm of patient obtains patient injury's arm by three-dimensional reconstruction
Forearm brace model and large arm brace model；
Elbow joint brace hinge design: the three-dimensional space based on determined by ulna, humerus and radius and three-dimensional space institute are right
The forearm brace model and large arm brace model answered, design bridge the hinge of the forearm brace model and large arm brace model,
And the cental axial position and angle of the hinge are determined by the ulna, humerus and radius；
The design for guiding elbow joint brace to wear: in conjunction with the dissection of ulna distal end wrist position and proximal ulna elbow joint position
Characteristic point designs the location model that axial and circumferential positioning is carried out during wearing to elbow joint brace, so that elbow joint brace
After wearing, the rotary shaft of the hinge is overlapped with elbow joint real motion axis.
2. customizing design method as described in claim 1, which is characterized in that the specific step that the elbow joint brace customizes
Suddenly are as follows:
The CT image mirrors are the CT image of patient injury's arm by the CT image for obtaining the not injured arm of patient；
The CT image of patient injury's arm is split and three-dimensional reconstruction algorithm is utilized to rebuild skin model, humerus model, ruler
Bone model and radius model；
Expansion process is carried out to skin model, obtains brace model；
The brace model is sheared using three-dimensional shearing function, obtains forearm brace model and large arm brace model.
3. as claimed in claim 2 customize design method, which is characterized in that the elbow joint brace hinge design it is specific
Step are as follows:
Under a certain revolution space state determined by the humerus model, ulna model and radius model, to trochlea humeri into
Row cylinder fitting obtains fitting cylinder, and the central axis of the fitting cylinder is the true rotary shaft of elbow joint；
Hinge model is rebuild according to the measurement data of hinge under the revolution space state, the hinge model is connected across described
Between forearm brace model and large arm brace model, and, the central axis of the rotary shaft of the hinge model and the fitting cylinder
It is overlapped.
4. customizing design method as claimed in claim 3, which is characterized in that the design that the guidance elbow joint brace is worn
Specific steps are as follows:
The three-dimensional space based on determined by ulna, humerus and radius, design is according to processus styloideus ulnae on the forearm brace model
The first location model positioned；
According to the determination position of the first location model and hinge under the three-dimensional space state, on the forearm brace model
Design according to olecroanon advance by leaps and bounds row positioning the second location model, and, be positioned at processus styloideus ulnae to first location model
And second location model be positioned at olecroanon it is prominent when, the central axis weight of the rotary shaft of the hinge model and the fitting cylinder
It closes.
5. customizing design method as claimed in claim 4, which is characterized in that first location model and the second positioning mould
Type is multi-stage telescopic model structure.
6. customizing design method as described in claim 1, which is characterized in that further include to forearm brace model and large arm branch
The step of tool model is sheared, makes the forearm brace model and large arm brace model be cut into half opening formula.
7. customizing design method as described in claim 1, which is characterized in that further include in the forearm brace model and big
The step of air hole is designed on arm brace model.
8. customizing design method as described in claim 1, which is characterized in that further include in the forearm brace model and big
The step of perforation is designed on arm brace model, the perforation is for wearing restraining.
9. customizing design method as described in claim 1, which is characterized in that the rotation angle adjustable of the hinge.
10. customizing design method as described in claim 1, which is characterized in that further include by the forearm brace model, greatly
The step of arm brace model and hinge integration 3D printing.
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| CN201811131281.9A CN109147042A (en) | 2018-09-27 | 2018-09-27 | A kind of customization design method of elbow joint brace |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811131281.9A CN109147042A (en) | 2018-09-27 | 2018-09-27 | A kind of customization design method of elbow joint brace |
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| CN109147042A true CN109147042A (en) | 2019-01-04 |
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| CN201811131281.9A Pending CN109147042A (en) | 2018-09-27 | 2018-09-27 | A kind of customization design method of elbow joint brace |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113507890A (en) * | 2021-05-17 | 2021-10-15 | 哈尔滨工业大学 | Elbow joint flexion and extension three-dimensional motion analysis method and device based on CT image |
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| CN201535970U (en) * | 2009-11-05 | 2010-07-28 | 北京医模科技有限公司 | Multifunctional elbow knuckle model |
| US20120053697A1 (en) * | 2010-08-27 | 2012-03-01 | Palmer Andrew K | Elbow prosthesis and method for use |
| CN105434085A (en) * | 2016-01-11 | 2016-03-30 | 王金成 | 3D printed individualized customized full wrist joint and manufacturing method thereof |
| CN107174381A (en) * | 2017-05-11 | 2017-09-19 | 南方医科大学 | A kind of finger prosthesis articular prosthesis preparation method |
| CN108478317A (en) * | 2018-05-09 | 2018-09-04 | 影为医疗科技(上海)有限公司 | A kind of personalization elbow joint brace and its construction method |
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2018
- 2018-09-27 CN CN201811131281.9A patent/CN109147042A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201535970U (en) * | 2009-11-05 | 2010-07-28 | 北京医模科技有限公司 | Multifunctional elbow knuckle model |
| US20120053697A1 (en) * | 2010-08-27 | 2012-03-01 | Palmer Andrew K | Elbow prosthesis and method for use |
| CN105434085A (en) * | 2016-01-11 | 2016-03-30 | 王金成 | 3D printed individualized customized full wrist joint and manufacturing method thereof |
| CN107174381A (en) * | 2017-05-11 | 2017-09-19 | 南方医科大学 | A kind of finger prosthesis articular prosthesis preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113507890A (en) * | 2021-05-17 | 2021-10-15 | 哈尔滨工业大学 | Elbow joint flexion and extension three-dimensional motion analysis method and device based on CT image |
| WO2022241613A1 (en) * | 2021-05-17 | 2022-11-24 | 哈尔滨工业大学 | Elbow joint flexion and extension three-dimensional motion analysis method and apparatus based on ct images |
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Effective date of registration: 20231206 Address after: 200135 Room 101, 1st Floor, Building 1, No. 269 Lianchuang Road, Pudong New Area, Shanghai Applicant after: SHANGHAI TAOYING MEDICAL TECHNOLOGY CO.,LTD. Address before: 200240 No. 800, Dongchuan Road, Shanghai, Minhang District Applicant before: SHANGHAI JIAO TONG University |