CN109142343B - Application of pyridine derivative in preparation of plasma sterilization indicator - Google Patents
Application of pyridine derivative in preparation of plasma sterilization indicator Download PDFInfo
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- CN109142343B CN109142343B CN201811005178.XA CN201811005178A CN109142343B CN 109142343 B CN109142343 B CN 109142343B CN 201811005178 A CN201811005178 A CN 201811005178A CN 109142343 B CN109142343 B CN 109142343B
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 80
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 80
- 150000003222 pyridines Chemical class 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 64
- 239000003795 chemical substances by application Substances 0.000 claims description 20
- 239000000839 emulsion Substances 0.000 claims description 20
- XNRNJIIJLOFJEK-UHFFFAOYSA-N sodium;1-oxidopyridine-2-thione Chemical compound [Na+].[O-]N1C=CC=CC1=S XNRNJIIJLOFJEK-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 10
- 239000002518 antifoaming agent Substances 0.000 claims description 10
- 239000012752 auxiliary agent Substances 0.000 claims description 10
- 239000011230 binding agent Substances 0.000 claims description 10
- 239000008367 deionised water Substances 0.000 claims description 10
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000002952 polymeric resin Substances 0.000 claims description 10
- 239000004814 polyurethane Substances 0.000 claims description 10
- 229920002635 polyurethane Polymers 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 229920003002 synthetic resin Polymers 0.000 claims description 10
- 239000002562 thickening agent Substances 0.000 claims description 10
- JBTHDAVBDKKSRW-UHFFFAOYSA-N chembl1552233 Chemical compound CC1=CC(C)=CC=C1N=NC1=C(O)C=CC2=CC=CC=C12 JBTHDAVBDKKSRW-UHFFFAOYSA-N 0.000 claims description 2
- 230000008859 change Effects 0.000 abstract description 16
- 238000000034 method Methods 0.000 abstract description 10
- 230000008569 process Effects 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 238000011160 research Methods 0.000 abstract description 3
- 239000000975 dye Substances 0.000 description 27
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 10
- 239000007789 gas Substances 0.000 description 9
- 230000009471 action Effects 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- 239000000984 vat dye Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- FGVVTMRZYROCTH-UHFFFAOYSA-N pyridine-2-thiol N-oxide Chemical compound [O-][N+]1=CC=CC=C1S FGVVTMRZYROCTH-UHFFFAOYSA-N 0.000 description 5
- -1 amino, hydroxyl Chemical group 0.000 description 4
- QHNCWVQDOPICKC-UHFFFAOYSA-N copper;1-hydroxypyridine-2-thione Chemical compound [Cu].ON1C=CC=CC1=S.ON1C=CC=CC1=S QHNCWVQDOPICKC-UHFFFAOYSA-N 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- 229940043810 zinc pyrithione Drugs 0.000 description 4
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 239000002696 acid base indicator Substances 0.000 description 3
- 229960002026 pyrithione Drugs 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- 241001052560 Thallis Species 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- YSWAWAYOPDDQJN-UHFFFAOYSA-N cadmium(2+);1-oxidopyridine-2-thione Chemical compound [Cd+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S YSWAWAYOPDDQJN-UHFFFAOYSA-N 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000005672 electromagnetic field Effects 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
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- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 108010077805 Bacterial Proteins Proteins 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000004234 Yellow 2G Substances 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000002479 acid--base titration Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- YRUKXDOALJRQDE-UHFFFAOYSA-N barium(2+) 1-oxidopyridine-2-thione Chemical compound [Ba++].[O-]n1ccccc1=S.[O-]n1ccccc1=S YRUKXDOALJRQDE-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- FTZLWXQKVFFWLY-UHFFFAOYSA-L disodium;2,5-dichloro-4-[3-methyl-5-oxo-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazol-1-yl]benzenesulfonate Chemical compound [Na+].[Na+].CC1=NN(C=2C(=CC(=C(Cl)C=2)S([O-])(=O)=O)Cl)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 FTZLWXQKVFFWLY-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical class I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002184 metal Chemical class 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 231100000606 suspected carcinogen Toxicity 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 235000019235 yellow 2G Nutrition 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
Abstract
The patent relates to the field of plasma sterilization indication and discloses application of a pyridine derivative in preparation of a plasma sterilization indicator. The research of the invention discovers the new application of the pyridine derivative for the first time, the pyridine derivative is helpful for promoting the dye to generate obvious color change before and after the hydrogen peroxide plasma sterilization, the color after the sterilization can not be recovered to the original color, the color stability is excellent, and whether the sterilization target object is subjected to the sterilization process or not can be reliably judged; the pyridine derivative can control the color change speed of the dye in hydrogen peroxide plasma, so that whether the sterilization condition of a sterilization target object is proper or not can be judged through the change of the color tone.
Description
Technical Field
The patent relates to the field of plasma sterilization indicators, and more particularly to the use of pyridine derivatives in the preparation of plasma sterilization indicators.
Background
With the rapid development of medical health and health care and the continuous improvement of medical technology, various precision instruments and equipment are gradually popularized and applied, and the equipment can not be sterilized at high temperature (mainly high-temperature high-pressure steam and high-temperature dry heat). In order to solve this problem, various low-temperature chemical sterilization methods have been developed, such as ethylene oxide low-temperature sterilization applied to hospital sterilization in the 50 th century, and ethylene oxide sterilizers are widely used by some large-city hospitals in the U.S. and china by the middle of the 90 th century. The epoxy ethane has the function of killing various microorganisms such as bacteria, spores, fungi, viruses and the like; the sterilization mechanism is combined with amino, hydroxyl, carboxyl or sulfydryl in bacterial protein molecules, enzymes and nucleic acid to damage the bacterial cells, thereby achieving the sterilization effect. However, ethylene oxide is toxic and is a suspected carcinogen, and besides extremely strict indoor air concentration control, complicated purification and emission treatment is also needed, so that the operation period is long; the other widely used method is low-temperature steam formaldehyde sterilization, the sterilization mechanism of the method is similar to that of ethylene oxide, and the method also has the defects of gas toxicity, strict concentration control and purification treatment, long sterilization operation period and the like.
In the 90 s of the 20 th century, plasma sterilization began to be a pilot test as a new low temperature sterilization technique. Plasma is generated by gas under the action of heating or strong electromagnetic field, and mainly comprises electrons, ions, atoms, molecules, active free radicals, rays and the like, namely the gas slurry is called as a material aggregation state. The existing plasma sterilization is mainly performed by exciting hydrogen peroxide (H2O2) into 'gas slurry' for sterilization, wherein the hydrogen peroxide (H2O2) is an active oxidant, and the decomposition products of the hydrogen peroxide are water and nascent oxygen. The sterilization mechanism of hydrogen peroxide plasma is mainly caused by the combined action of ultraviolet rays, high-energy particles and active free radicals, wherein active substances such as active free radicals, hydrogen peroxide radicals and hydroxyl radicals are combined with proteins and nucleic acids in bacteria to destroy the metabolism of the bacteria, so that the sterilization effect is achieved. The hydrogen peroxide low-temperature plasma sterilization system has the characteristics that: the sterilization speed is high, only about 55 minutes is needed, and the detoxification time is not needed; no toxic substance is left, and the final decomposition product is water and oxygen which are safe for the environment and medical staff. Therefore, the hydrogen peroxide low-temperature plasma sterilization system (particularly GB/T32309-2015) can be used for sterilizing medical instruments and also used in the industries and works requiring sterilization of sanitary materials, food, tableware and the like.
Important in the application of these sterilization methods are: whether the equipment to be sterilized is subjected to the sterilization process is judged, and whether the sterilization effect on the equipment is proper is checked. On the other hand, indicator compositions that change color tone during sterilization have become a means of determining whether sterilization has been performed or a means of inspecting whether the sterilization effect is appropriate.
Various indicator compositions exist for indicating the presence of hydrogen peroxide based on the principle of acid-base titration. The acid-base indicators each have a different pKa value and therefore a different acid-base indicating color. The method comprises the steps of compounding a suitable acid-base indicator with iodide, metal salt, transition metal salt and the like, and compounding a suitable aqueous polymer solution with hydrogen sulfide, sodium hypochlorite and the like to filter test paper to form the indicator test paper; the hydrogen peroxide forms plasma under the action of a high-frequency electromagnetic field in the sterilizer, active factors such as free radicals HO, perhydroxyl free radicals HO2, excited state H2O2, active oxygen atoms O, active hydrogen atoms H and the like in the plasma react with the acid-base indicator to generate color change, so the prepared test paper can detect the hydrogen peroxide. Also, some products in the form of printing ink are applied to a hydrogen peroxide low-temperature plasma sterilization system based on the chemical action, but the finished indicator product is unstable before and after use, such as the product is influenced by external air moisture and acid and alkali substances of contact products, the indicator changes are not obvious after being stored for a long time, or the indicator fades during the recording period after being processed by the sterilization system, and the like, which all affect the daily management of a hospital supply center.
The pyridine derivatives have unique biological activity, low toxicity and high systemic property, and are often used as structural building blocks of medicines and pesticides. However, there is currently no document disclosing the role of pyridine derivatives in plasma sterilization indications.
Disclosure of Invention
In view of the above, in order to overcome at least one of the deficiencies in the prior art, the present patent finds a substance that promotes the color change of the dye in the hydrogen peroxide plasma and promotes the color fixation of the dye after the color change, and researches find that the pyridine derivative has the characteristics of promoting the color change of the dye in the hydrogen peroxide plasma and effectively fixing the color after the color change, and is suitable for indicating plasma sterilization.
In order to solve the technical problems, the patent adopts the following technical scheme:
use of a pyridine derivative for the preparation of a plasma sterilisation indicator.
Further, the pyridine derivative is one or more of pyridone, pyrithione or a pyrithione salt.
Further, the pyrithione salt is one or more of copper pyrithione, zinc pyrithione, sodium pyrithione, magnesium pyrithione, cadmium pyrithione, and zirconium pyrithione.
Further, the plasma sterilization indicator is a hydrogen peroxide plasma sterilization indicator.
Further, the component which plays a role in changing color in the plasma sterilization indicator is a dye.
Further, the dye which plays a role in changing color in the plasma sterilization indicator is a vat dye or a sulfur vat dye.
The pyridine derivative and the dye generate other colors under the fading or matching action under the action of hydrogen peroxide with strong oxidation effect, and the action of the pyridine derivative is very critical and important, influences and controls the color development speed and the color development stability, and plays a role in controlling the color development speed and the color fixation stably.
The hydrogen peroxide plasma sterilization indicator is substantially the same as the dye used in the ethylene oxide gas sterilization indicator. However, because the sterilization mechanisms of the ethylene oxide gas and the dye are different, the ethylene oxide gas kills the thalli through alkylation, and the hydrogen peroxide plasma kills the thalli through stronger (radio frequency ion) oxidation, so the dye discoloration mechanisms of the ethylene oxide gas and the dye are different, and the ethylene oxide gas and the dye can be stably generated or degenerated into another color after the reaction; however, even if hydrogen peroxide having a strong oxidizing action reacts with a dye after the hydrogen peroxide plasma is generated in the sterilizer, the indicator may not change color, or may change color but may be unstable or may not change color after being left for a long time. It has been found that the incorporation of a pyridine derivative into an indicator for hydrogen peroxide plasma sterilization can more stably prevent discoloration of a dye which has been discolored during hydrogen peroxide plasma sterilization.
The pyridine derivative is preferably a pyridine derivative having an ionizing group, such as copper pyrithione, zinc pyrithione, sodium pyrithione, etc., and particularly, the pyridine derivative is used in the preparation of a plasma sterilization indicator in which the dye serving as a discoloration indicator is a vat dye or a sulfur vat dye. The vat dye and the sulfur vat dye are not dissolved in an aqueous system, although the leuco dye can be dissolved in the aqueous system, a non-aqueous solution can be generated along with the reduction of the pH value of the system, and the introduced copper pyrithione, sodium pyrithione and zinc pyrithione with ionized groups can stabilize the system and play a role in improving the plasma sensitivity.
This patent compares with prior art has following beneficial effect:
the research of the invention discovers the new application of the pyridine derivative for the first time, the pyridine derivative is helpful for promoting the dye to generate obvious color change before and after the hydrogen peroxide plasma sterilization, the color after the sterilization can not be recovered to the original color, the color stability is excellent, and whether the sterilization target object is subjected to the sterilization process or not can be reliably judged; the pyridine derivative can control the color change speed of the dye in hydrogen peroxide plasma, so that whether the sterilization condition of a sterilization target object is proper or not can be judged through the change of the color tone.
Detailed Description
This patent is described in further detail below with reference to specific examples.
Example 1
In this embodiment, the plasma sterilization indicator includes the following components in parts by weight:
dye: 5 parts of reactive red B and 0.5 part of OB dye blue;
pyridine derivatives: 2 parts of sodium pyrithione;
aqueous polymer resin binder: 30 parts of polyurethane emulsion and 30 parts of acrylic emulsion;
auxiliary agent: 2 parts of nano titanium dioxide, 0.5 part of rheological agent, 0.7 part of film forming agent, 0.1 part of defoaming agent and 10 parts of thickening agent;
solvent: deionized water/alcohol 19.2 parts.
Example 2
In this embodiment, the plasma sterilization indicator includes the following components in parts by weight:
dye: active blue BF4R 2.4.4 parts, disperse pink R3L 2 parts;
pyridine derivatives: 2 parts of sodium pyrithione;
aqueous polymer resin binder: 40 parts of polyurethane emulsion and 20 parts of acrylic emulsion;
auxiliary agent: 3 parts of nano titanium dioxide, 0.3 part of rheological agent, 0.7 part of film forming agent, 0.4 part of defoaming agent and 10 parts of thickening agent; solvent: deionized water/alcohol 19.2 parts.
Example 3
In this embodiment, the plasma sterilization indicator includes the following components in parts by weight:
dye: active violet 5R 1 and vat yellow G0.5;
pyridine derivatives: 1 part of zinc pyrithione and 1 part of barium pyrithione;
aqueous polymer resin binder: 35 parts of polyurethane emulsion and 35 parts of acrylic emulsion;
auxiliary agent: 3 parts of nano titanium dioxide, 0.2 part of rheological agent, 1.0 part of film forming agent, 0.3 part of defoaming agent and 10 parts of thickening agent; solvent: deionized water/alcohol 12.5 parts.
Example 4
In this embodiment, the plasma sterilization indicator includes the following components in parts by weight:
dye: 0.4 part of vat black B, 1.0 part of active violet 5R, 0.1 part of disperse blue RRL and 0.2 part of vat yellow G; pyridine derivatives: 1 part of sodium pyrithione and 1 part of copper pyrithione;
aqueous polymer resin binder: 40 parts of polyurethane emulsion and 30 parts of acrylic emulsion;
auxiliary agent: 5 parts of nano titanium dioxide, 0.2 part of rheological agent, 0.8 part of film forming agent, 0.2 part of defoaming agent and 10 parts of thickening agent; solvent: 10.1 parts of deionized water/alcohol.
Example 5
In this embodiment, the plasma sterilization indicator includes the following components in parts by weight:
dye: 3.5 parts of vat blue RS;
pyridine derivatives: 2 parts of sodium pyrithione;
aqueous polymer resin binder: 30 parts of polyurethane emulsion and 30 parts of acrylic emulsion;
auxiliary agent: 4 parts of nano titanium dioxide, 0.5 part of rheological agent, 0.7 part of film forming agent, 0.1 part of defoaming agent and 10 parts of thickening agent; solvent: deionized water/alcohol 19.2 parts.
Example 6
In this embodiment, the plasma sterilization indicator includes the following components in parts by weight:
dye: 4.4 parts of vat yellow WG;
pyridine derivatives: 2 parts of sodium pyrithione;
aqueous polymer resin binder: 40 parts of polyurethane emulsion and 20 parts of acrylic emulsion;
auxiliary agent: 3 parts of nano titanium dioxide, 0.3 part of rheological agent, 0.7 part of film forming agent, 0.4 part of defoaming agent and 10 parts of thickening agent;
solvent: deionized water/alcohol 19.2 parts.
Example 7
In this embodiment, the plasma sterilization indicator includes the following components in parts by weight:
dye: 2 parts of vulcanized reduced indigo and 0.5 part of disperse pink;
pyridine derivatives: 1.5 parts of sodium pyrithione;
aqueous polymer resin binder: 35 parts of polyurethane emulsion and 35 parts of acrylic emulsion;
auxiliary agent: 2 parts of nano titanium dioxide, 0.2 part of rheological agent, 1.0 part of film forming agent, 0.3 part of defoaming agent and 10 parts of thickening agent;
solvent: 10.1 parts of deionized water/alcohol.
Example 8
In this embodiment, the plasma sterilization indicator includes the following components in parts by weight:
dye: 1.5 parts of vulcanized vat yellow 2G and 0.2 part of OB dye blue;
pyridine derivatives: 1.5 parts of sodium pyrithione and 0.5 part of cadmium pyrithione;
aqueous polymer resin binder: 40 parts of polyurethane emulsion and 30 parts of acrylic emulsion;
auxiliary agent: 5 parts of nano titanium dioxide, 0.2 part of rheological agent, 0.8 part of film forming agent, 0.2 part of defoaming agent and 10 parts of thickening agent;
solvent: 10.1 parts of deionized water/alcohol.
Comparative example 1
This comparative example is different from example 1 in that the pyridine derivative is not included in the plasma sterilization indicator, and the other example is the same as example 1.
Comparative example 2
This comparative example is different from example 6 in that the pyridine derivative is not included in the plasma sterilization indicator, and the other example is the same as example 6.
The test method comprises the following steps:
1. the plasma sterilization indicators of the above-described examples and comparative examples were manually coated on a substrate of polypropylene-based synthetic paper (Yupo FGS-250, manufactured by Yupo corporation) using a loop-rod type wet film coater of 0.45m/m to prepare corresponding indicator paper, and the initial color of each indicator paper was recorded in Table 1.
2. The sterilization treatment (2-minute elimination treatment and short-cycle treatment) was performed with a plasma sterilizer (LK/DZK series) of the genu laken medical science and technology ltd, and the discoloration results were recorded in table 1. The 2-minute abatement treatment is a treatment in which the sterilization chamber is depressurized to about 0.5torr, high-frequency energy is applied to the sterilization chamber in this state to produce an air plasma state, the pressure is restored to a first pressure, the sterilization chamber is depressurized to about 0.4torr again, and hydrogen peroxide is injected and diffused for 2 minutes; the short cycle treatment is a treatment in which hydrogen peroxide is diffused for 6 minutes, then slightly decompressed, and then high-frequency energy is applied to produce a low-temperature plasma state of hydrogen peroxide, and then hydrogen peroxide is injected and diffused for 8 minutes to apply high-frequency energy, followed by "2-minute elimination treatment".
3. The color change was recorded in table 1 after placing each indicator paper subjected to hydrogen peroxide plasma sterilization treatment in a constant temperature and humidity chamber at 23 ℃ and 90% RH for 1 month.
TABLE 1
As can be seen from the test results in table 1, the above examples exhibited significant color transition before and after the plasma sterilization treatment, and the color after the transition could be stably present. From the test results of example 1 and comparative example 1, and example 6 and comparative example 2, it is understood that the pyridine derivative plays a key role in plasma sterilization indication, in example 1, the pyridine derivative is a key factor for indicating whether or not the indicator undergoes color transition before and after the plasma sterilization treatment, and in example 6, the pyridine derivative affects the color difference of the indicator undergoing color transition before and after the plasma sterilization treatment.
It should be understood that the above examples of the present patent are only examples for clearly illustrating the present patent, and are not intended to limit the embodiments of the present patent. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of this patent shall be included in the protection scope of the claims of this patent.
Claims (1)
1. The application of pyridine derivatives in the preparation of hydrogen peroxide plasma sterilization indicators,
the hydrogen peroxide plasma sterilization indicator comprises the following components in parts by weight: dye: 5 parts of reactive red B, 0.5 part of OB dye blue, and pyridine derivatives: 2 parts of sodium pyrithione, an aqueous polymer resin binder: 30 parts of polyurethane emulsion, 30 parts of acrylic emulsion, and an auxiliary agent: 2 parts of nano titanium dioxide, 0.5 part of rheological agent, 0.7 part of film forming agent, 0.1 part of defoaming agent, 10 parts of thickening agent and solvent: 19.2 parts of deionized water/alcohol; or
The hydrogen peroxide plasma sterilization indicator comprises the following components in parts by weight: dye: vat yellow WG 4.4 parts, pyridine derivative: 2 parts of sodium pyrithione, an aqueous polymer resin binder: 40 parts of polyurethane emulsion, 20 parts of acrylic emulsion, and an auxiliary agent: 3 parts of nano titanium dioxide, 0.3 part of rheological agent, 0.7 part of film forming agent, 0.4 part of defoaming agent, 10 parts of thickening agent and solvent: deionized water/alcohol 19.2 parts.
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| CN101618226A (en) * | 2009-08-12 | 2010-01-06 | 成都老肯科技有限公司 | Hydrogen peroxide plasma sterilizer and sterilizing method thereof |
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| CN201182775Y (en) * | 2007-12-28 | 2009-01-21 | 国家纳米技术与工程研究院 | Color-changing printing ink indicating card for indicating disinfection |
| CN101965203A (en) * | 2008-03-10 | 2011-02-02 | 保木医疗股份有限公司 | Plasma sterilization indicator |
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