CN109142196A - Three classification reagent for hemocyte analyzers of one kind - Google Patents
Three classification reagent for hemocyte analyzers of one kind Download PDFInfo
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- CN109142196A CN109142196A CN201810944015.1A CN201810944015A CN109142196A CN 109142196 A CN109142196 A CN 109142196A CN 201810944015 A CN201810944015 A CN 201810944015A CN 109142196 A CN109142196 A CN 109142196A
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- reagent
- dilution
- water
- filtering
- cleaning solution
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 35
- 210000003677 hemocyte Anatomy 0.000 title claims description 8
- 229940000351 hemocyte Drugs 0.000 title claims description 8
- 238000004140 cleaning Methods 0.000 claims abstract description 10
- 238000010790 dilution Methods 0.000 claims abstract description 10
- 239000012895 dilution Substances 0.000 claims abstract description 10
- 239000003219 hemolytic agent Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 239000000243 solution Substances 0.000 claims abstract description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract 10
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims abstract 6
- 239000000203 mixture Substances 0.000 claims abstract 5
- 239000011780 sodium chloride Substances 0.000 claims abstract 5
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims abstract 4
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims abstract 4
- 235000019796 monopotassium phosphate Nutrition 0.000 claims abstract 4
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims abstract 4
- 238000002360 preparation method Methods 0.000 claims abstract 4
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims abstract 4
- 239000003242 anti bacterial agent Substances 0.000 claims abstract 3
- 229910052938 sodium sulfate Inorganic materials 0.000 claims abstract 3
- 235000011152 sodium sulphate Nutrition 0.000 claims abstract 3
- 239000004094 surface-active agent Substances 0.000 claims abstract 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims abstract 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims abstract 2
- 239000013504 Triton X-100 Substances 0.000 claims abstract 2
- 229920004890 Triton X-100 Polymers 0.000 claims abstract 2
- 229960000800 cetrimonium bromide Drugs 0.000 claims abstract 2
- 239000003995 emulsifying agent Substances 0.000 claims abstract 2
- 239000001103 potassium chloride Substances 0.000 claims abstract 2
- 235000011164 potassium chloride Nutrition 0.000 claims abstract 2
- 235000010288 sodium nitrite Nutrition 0.000 claims abstract 2
- 239000000706 filtrate Substances 0.000 claims 3
- 238000002558 medical inspection Methods 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 abstract 1
- AEDZKIACDBYJLQ-UHFFFAOYSA-N ethane-1,2-diol;hydrate Chemical compound O.OCCO AEDZKIACDBYJLQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 description 10
- 238000001514 detection method Methods 0.000 description 8
- 102000001554 Hemoglobins Human genes 0.000 description 7
- 108010054147 Hemoglobins Proteins 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 238000003756 stirring Methods 0.000 description 6
- 210000000601 blood cell Anatomy 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 210000000265 leukocyte Anatomy 0.000 description 5
- 239000002872 contrast media Substances 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000003908 quality control method Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000002751 lymph Anatomy 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention relates to medical inspection instrument reagent, in particular to one kind three is classified the reagent and its preparation method and production technology that cellanalyzer uses.Reagent includes dilution, hemolytic agent, cleaning solution.This reagent is the universal reagent of multiple instruments, and Mai Rui, Uritest, Te Kang, Pu Kang, thunder Du Jun can be used, and with little WBC ± 7.5% of original-pack reagent relative deviation R, RBC ± 3%, HGB ± 3%, MCV ± 3%, PLT ± 12.5%, has preferable correlation.Dilution is by sodium chloride, disodium hydrogen phosphate, potassium dihydrogen phosphate, potassium chloride), EDTANa2, ethylene glycol phenyl ether and water composition, obtained through filtering.Hemolytic agent is made of disodium hydrogen phosphate, potassium dihydrogen phosphate, cetrimonium bromide, Triton X-100 (emulsifier 0p), sodium nitrite and water, is obtained through filtering.Cleaning solution is made of sodium chloride, sodium sulphate, antibacterial agent, surfactant.Raw material of the invention is cheap, is easy to get, simple to operate.
Description
Technical field
The present invention relates to medical inspection instrument reagents, and in particular to three classification reagent for hemocyte analyzers of one kind is fitted
For stepping auspicious, Uritest, Te Kang, Pu Kang, three classification cellanalyzer of thunder Du series.
Background technique
Blood cell analysis is commonly used one of the inspection project in medical laboratory, is not only examined the diagnosis of disease, identification
Disconnected, observation of curative effect and prognostic analysis have important clinical meaning, and also have certain values to the assessment of health status.
Hemolytic agent destroys the form that cell is analyzed needed for red blood cell, dissolution hemoglobin, maintenance before being used for blood cell analysis,
Consequently facilitating classified counting of leucocyte and hemoquant hemoglobin quantitative test.
Dilution is used for the dilution of sample before cell analysis.
Cleaning solution is used for the cleaning and flushing of blood cell analyzer sample injector, valve and pipe-line system.
Reagent price now in the market is expensive, and can only use matched reagent, causes multi-model troublesome in poeration and at high cost.
Summary of the invention
It is an object of the invention to invent generally applicable, reliable performance, alternative import on a kind of at low cost, multi-model to produce
Product, the one kind three to meet clinical needs classification reagent for hemocyte analyzers.
Basic principle
Dilution is a kind of diluting cells, the buffering liquid for preventing intercellular aggregation.There are osmotic pressure appropriate, ionic strength
Rate is arrived with point, the integrality and original volume of haemocyte can be maintained within a few hours.
The matched dilution of hemolytic agent is used cooperatively, and by hemoglobinometry, white blood cell count(WBC) and is divided based on group
Number, and the histogram that leucocyte divides group is provided.This hemolytic agent is a kind of New Blood analyzer hemolytic agent.With quick dissolution
Red blood cell makes it release hemoglobin, and the fragment of red blood cell can be made to be unlikely to interfere the counting of leucocyte；At the same time will
Red blood cell releases hemoglobin and is transformed into stable coloured haemoglobin complexes, so that the concentration of detection hemoglobin contains
Amount.Hemolytic agent will avoid damage to as far as possible the integrality of leucocyte core in lysed erythrocyte, only in this way could be convenient for white thin
The counting and classification of born of the same parents.Cleaning solution is used for the cleaning and flushing of blood cell analyzer sample injector, valve and pipe-line system.
Specific embodiment:
In order to preferably explain the present invention, it is described further now in conjunction with following specific embodiments, but the present invention is unlimited
In specific embodiment.
Embodiment 1
(1) formula of dilution of the present invention:
Required material is successively weighed by above-mentioned formula, is added in 1L deionized water, stirring and dissolving under room temperature, rear stirring is
Even, with after the filter membrane filtering of 0.8 aperture micron under clean environment, the pH value for measuring solution should be in 7 ± 0.20 ranges；Electricity
Conductance (ρ) should be within the scope of 18 ± 0.5mS/cm；Osmotic concentration should be in 290 ± 10mmol/L (mOsm/kg) range.
(2) haemolysis agent prescription of the invention are as follows:
Required material is successively weighed by above-mentioned formula, is added in 1L deionized water, stirring and dissolving under room temperature, rear stirring is
Even, with after the filter membrane filtering of 0.8 aperture micron under clean environment, pH value should be in 7.75 ± 0.30 ranges.
(3) cleaning formula of liquid of the invention is
Required material is successively weighed by above-mentioned formula, is added in 1L deionized water, stirring and dissolving under room temperature, rear stirring is
Even, with after the filter membrane filtering of 0.8 aperture micron under clean environment, pH value should be in 9 ± 0.50 ranges.
Stability test detection
With 1 gained reagent of embodiment and the reagent to circulate currently on the market is randomly selected (not cause to slander local
Side does not illustrate) experiment detection sample is compared, quality-control product used is to step auspicious quality-control product, lot number are as follows: DC20318N, detection
It the results are shown in Table 1.
The reagent of the present invention of table 1 and contrast agents Detection of Stability result
Reagent of the present invention and contrast agents Detection of Stability result
Reagent of the present invention and contrast agents Detection of Stability result
Remarks: quality-control product DC20318N target value is
| Project | Target value |
| WBC | 9.1±1.0 |
| Lymph | 3.2±0.5 |
| Mid% | 8.1±8.1 |
| Gran% | 56.6±7.0 |
| Lymph% | 35.3±7.0 |
| Mid | 0.7±0.5 |
| Gran | 5.2±0.5 |
| HGB | 138±5 |
| RBC | 4.47±0.30 |
| HCT | 41.8±4.5 |
| MCV | 93.5±5.0 |
| MCH | 30.9±3.0 |
| MCHC | 330±40 |
| PLT | 245±30 |
In conjunction with table 1 as a result, 1 agent cell analysis ability of embodiment and stability are substantially better than contrast agents, therefore this hair
Bright reagent is greatly increased in terms of cell analysis ability and stability, with good development space, while because
Cost is relatively low, easy to operate, enhances present invention competitiveness in the market.
Correlation detection
With 1 gained reagent of embodiment as experimental group, chooses step auspicious 2900 cellanalyzer, Uritest 2981 respectively
Cellanalyzer, special 3500 cellanalyzer of health, 6100 cellanalyzer of general health, thunder are shut out 7600 cellanalyzers
Original-pack reagent as a control group, compares experiment respectively, measure the leucocytes of 60 identical samples, red blood cell, hemoglobin,
Mean corpuscular volume (MCV), platelet content, if little WBC ± 7.5% of relative deviation R, RBC ± 3%, HGB ± 3%, MCV ±
3%, PLT ± 12.5% indicates that two reagents have preferable correlation.Testing result is shown in Table 2-11.
Table 2 steps auspicious control group and 1 reagent relative deviation R of embodiment
3 relative deviation coincidence rate of table summarizes
4 Uritest control group of table and 1 reagent relative deviation R of embodiment
5 relative deviation coincidence rate of table summarizes
The special health control group of table 6 and 1 reagent relative deviation R of embodiment
7 relative deviation coincidence rate of table summarizes
The general health control group of table 8 and 1 reagent relative deviation R of embodiment
9 relative deviation coincidence rate of table summarizes
10 thunder of table Du's control group and 1 reagent relative deviation R of embodiment
11 relative deviation coincidence rate of table summarizes
By table 2-11 it is found that 1 reagent of embodiment and stepping auspicious 2900 cellanalyzer, 2981 blood cell analysis of Uritest
Instrument, special 3500 cellanalyzer of health, 6100 cellanalyzer of general health, thunder are shut out the original-pack reagents of 7600 cellanalyzers,
It carries out leucocyte, red blood cell, hemoglobin, mean corpuscular volume (MCV), platelet content measurement result to compare, relative deviation R is equal
No more than WBC ± 7.5%, RBC ± 3%, HGB ± 3%, MCV ± 3%, PLT ± 12.5%, it is preferable to indicate that two reagents have
Correlation.Correlation is good, as a result consistent credible.Reagent of the present invention can be general with the above instrument.
Claims (4)
- The reagent for hemocyte analyzers 1. one kind three is classified, which is characterized in that it includes dilution, hemolytic agent, cleaning solution；The dilution is by sodium chloride (8.2 g/L), disodium hydrogen phosphate (5.8g/L), potassium dihydrogen phosphate (0.27g/L), potassium chloride (0.2 g/L), EDTANa2(0.3 g/L), ethylene glycol phenyl ether (3ml/L) and water composition；The hemolytic agent is by disodium hydrogen phosphate (46.7g/L), potassium dihydrogen phosphate (6.3 g/L), cetrimonium bromide (50g/L), Triton X-100 (emulsifier 0p) (50ml/L), sodium nitrite (1.1g/L) and water composition；The cleaning solution is made of sodium chloride 12g/L, sodium sulphate 10g/L, antibacterial agent 2g/L, surfactant 2g/L and water.
- 2. a kind of three classification reagent for hemocyte analyzers according to claim 1, which is characterized in that the preparation of dilution It is that at normal temperature, after each composition is dissolved completely in water, filtering is taken obtained by filtrate.
- 3. a kind of three classification reagent for hemocyte analyzers according to claim 1, which is characterized in that the preparation of hemolytic agent It is that at normal temperature, after each composition is dissolved completely in water, filtering is taken obtained by filtrate.
- 4. a kind of three classification reagent for hemocyte analyzers according to claim 1, which is characterized in that the preparation of cleaning solution It is filtering after being at normal temperature completely dissolved sodium chloride 12g/L, sodium sulphate 10g/L, antibacterial agent 2g/L, surfactant 2g/L, Take filtrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810944015.1A CN109142196A (en) | 2018-08-18 | 2018-08-18 | Three classification reagent for hemocyte analyzers of one kind |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810944015.1A CN109142196A (en) | 2018-08-18 | 2018-08-18 | Three classification reagent for hemocyte analyzers of one kind |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109142196A true CN109142196A (en) | 2019-01-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810944015.1A Pending CN109142196A (en) | 2018-08-18 | 2018-08-18 | Three classification reagent for hemocyte analyzers of one kind |
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110160941A (en) * | 2019-05-24 | 2019-08-23 | 山东省医学科学院基础医学研究所 | Three classification reagent for hemocyte analyzers of one kind |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4521518A (en) * | 1980-06-16 | 1985-06-04 | Coulter Electronics, Inc. | Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes |
| CN1037966A (en) * | 1988-01-29 | 1989-12-13 | 阿盖尔钻石销售有限公司 | Sorting and/or examine the method and apparatus of jewel homogeneity |
| CN1222677A (en) * | 1997-10-31 | 1999-07-14 | 中国人民武装警察部队江苏省总队医院 | Diluent and blood solvent cleaning liquid for blood cell counter and their preparation |
| CN1271861A (en) * | 2000-04-26 | 2000-11-01 | 李宽明 | Non-cyanogen hemolysin |
| CN101281193A (en) * | 2008-06-04 | 2008-10-08 | 南昌百特生物高新技术有限公司 | Blood cell analyzer dilution as well as hemolytic agent |
| CN101281194A (en) * | 2008-06-04 | 2008-10-08 | 南昌百特生物高新技术有限公司 | Blood cell analyzer cleaning fluid |
| US20170328924A1 (en) * | 2014-11-26 | 2017-11-16 | Ronald Jones | Automated microscopic cell analysis |
-
2018
- 2018-08-18 CN CN201810944015.1A patent/CN109142196A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4521518A (en) * | 1980-06-16 | 1985-06-04 | Coulter Electronics, Inc. | Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes |
| CN1037966A (en) * | 1988-01-29 | 1989-12-13 | 阿盖尔钻石销售有限公司 | Sorting and/or examine the method and apparatus of jewel homogeneity |
| CN1222677A (en) * | 1997-10-31 | 1999-07-14 | 中国人民武装警察部队江苏省总队医院 | Diluent and blood solvent cleaning liquid for blood cell counter and their preparation |
| CN1271861A (en) * | 2000-04-26 | 2000-11-01 | 李宽明 | Non-cyanogen hemolysin |
| CN101281193A (en) * | 2008-06-04 | 2008-10-08 | 南昌百特生物高新技术有限公司 | Blood cell analyzer dilution as well as hemolytic agent |
| CN101281194A (en) * | 2008-06-04 | 2008-10-08 | 南昌百特生物高新技术有限公司 | Blood cell analyzer cleaning fluid |
| US20170328924A1 (en) * | 2014-11-26 | 2017-11-16 | Ronald Jones | Automated microscopic cell analysis |
Non-Patent Citations (1)
| Title |
|---|
| 都永芳 等: "新型溶血素在临床检验中的应用价值", 《临床医学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110160941A (en) * | 2019-05-24 | 2019-08-23 | 山东省医学科学院基础医学研究所 | Three classification reagent for hemocyte analyzers of one kind |
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