CN109125786A - A kind of preparation method of the antibacterial medical dressing of high intensity - Google Patents
A kind of preparation method of the antibacterial medical dressing of high intensity Download PDFInfo
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The present invention relates to a kind of preparation methods of antibacterial medical dressing of high intensity, belong to medical supplies preparation technical field.Reaction solid powder is made using Garlic Seeds and aloe as raw material in the present invention, then sodium alginate soln and high iron acid sodium reaction are generated into mixed dispersion liquid, potassium chloride is added into mixed dispersion liquid again and propylene glycol carries out dialysis treatment and oxidized solid powder is made, finally by carboxymethyl chitosan, react solid powder and the mixing of oxidized solid powder, high-intensitive antibacterial medical dressing is made after concentration, allicin ingredient in Garlic Seeds, with good bactericidal and bacteriostatic effect, there are anthraquinones in Chinese aloe leaf, help to repair wound while preventing from infecting, the present invention is adsorbed in iron ion in nutriment by ionic bond and chelation, it may advantageously facilitate the contraction and healing of wound, improve the air penetrability of medical dressing, help wound healing, it has broad application prospects.
Description
Technical field
The present invention relates to a kind of preparation methods of antibacterial medical dressing of high intensity, belong to medical supplies preparation technical field.
Background technique
Wound causes various various forms of wounds, such as lacerated wound, hurts, stabs, penetrating wound, for these wounds, passes
Doctor generally uses sterile gauze and topical antibiotic to handle on system.Gauze easily with skin wound tissue adhesion, usually break by when dressing
Bad newborn epithelium and granulation tissue, cause bleeding, this is not only unfavorable for the healing of wound, and makes Principle of Pain unbearably, together
When can also cause different types of infection.Wound infection is due to the inflammatory reaction that bacterium invades human skin and occurs, and is thin
Bacterium is prolific in human body as a result, its size, the depth, pollution level of degree and wound for infecting etc. are closely related.
Medical dressing is the articles of packet wound, to cover the medical material of sore, wound or other damages, in each doctor
It treats, shield treats place and suffers from very extensive application.Ideal dressing can keep the moist environment between wound and dressing, have
Water imbibition and penetrability appropriate prevent the surface of a wound dry, prevent surrounding normal skin from occurring rotten to the corn.In addition, need to have gas permeability,
The functions such as external bacterial invasion are prevented, and are not adhere to surface of a wound damage cambium in change dressings.In addition, being easy observation wound
Mouth cures state, nonirritant, is easy to use, and economy is high, then can become ideal dressing.
Medical dressing common at present includes natural gauze, the dressing of synthetic fibers class, the dressing of poly film class, foaming multi-cluster
Dressing, the dressing of hydrocolloid class, alginate dressing etc..Though natural gauze has certain a moisture absorption and protective effect, in agglutination
It easily is adhered wound, causes secondary damage, and permeability is poor, hemostatic capability deficiency etc..Aerogel dressing is by non-aqueous
Property polymer composition a kind of net high-polymer swelling body containing large quantity of moisture, be rich in moisture, wound moist can be kept, promote
Healing is a kind of current clinically used Medical dressing.But it is not easy to carry out moisture regulation, easily dipping surrounding tissue, and
Hydrogel intensity is poor, easy fracture.Alginate dressing and foam dressing, be suitble in arrive severe sepage wound nursing, respectively with algae
Silicate fiber and the preparation of polyurethane or polyurethane or polyvinyl alcohol foam, there are also antibacterial functions for addition silver ion.Alginates apply
Material water absorption can greatly, easily prevent adhesion at gel, discharge calcium ion or zinc ion promotion wound contraction and healing, be the excellent of silver ion
Good carrier, but inconvenient for use needs additionally to fix using secondary enclosed dressing, when removal, may have residual fiber left in wound side
Edge increases the workload of nursery work person；And foam dressing intensity is high, inside has hole bubble, and compressibility is good, and liquid absorption amount is big,
Ease for use is good, but is easy dipping surrounding skin, causes secondary injury, cell is possible to grow into hole, and adhesion wound is not easy to load
Silver-ion antibiotic.
Therefore, the medical of a kind of compatibility that can be improved the same surface of a wound, antibiotic property and biodegradable properties is developed
Dressing is highly desirable.
Summary of the invention
The technical problems to be solved by the invention, bad for current medical dressing bactericidal and bacteriostatic effect, air penetrability is poor, by force
Insufficient defect is spent, a kind of preparation method of antibacterial medical dressing of high intensity is provided.
In order to solve the above technical problems, the technical solution adopted by the present invention is that:
A kind of preparation method of the antibacterial medical dressing of high intensity, it is characterised in that specific preparation step are as follows:
(1) garlic clove is mixed with Chinese aloe leaf 5 ︰ 1 in mass ratio and is chopped into fritter investment beaker, impregnate garlic with sodium hydroxide solution
Valve and Chinese aloe leaf place the beaker isothermal reaction in water-bath, filtrate are obtained by filtration after reaction；
(2) according to parts by weight, by 28~30 parts of above-mentioned filtrates, 1.0~1.3 parts of sodium citrates, 2~4 parts of glycerol and 11~14
In part propylene glycol investment four-hole boiling flask, four-hole boiling flask is put into sonic oscillation instrument and vibrates obtained mixed liquor, into four-hole boiling flask
The iron chloride crystal powder of mixed liquor quality 3~5% is added, four-hole boiling flask is heated up, heated at constant temperature, heating is placed in baking oven
To constant weight, obtained reaction solid powder is spare for drying；
(3) it is put into after mixing sodium alginate and distilled water 1 ︰ 50 in mass ratio in beaker and is uniformly mixed obtained mixed solution, to
The Na2Fe04 crystal powder that mixed solution quality 3.0~3.5% is added in beaker uses blender by beaker under no light condition
It is mixed, mixed dispersion liquid is made；
(4) according to parts by weight, 80~85 parts of above-mentioned mixed dispersion liquids, 4~6 parts of propylene glycol and 1~2 part of potassium chloride investment are weighed
In reaction kettle, magnetic agitation is carried out, is poured into bag filter after stirring, mix products is made after dialysis 2~3 days, by mix products
It is placed in a vacuum drying oven dry until oxidized solid powder is made in product constant weight；
(5) according to parts by weight, 2.0~2.5 parts of carboxymethyl chitosans, 3~4 parts of spare reaction solid powders, 5~6 are weighed
It is uniformly mixed obtained mixed solution in the above-mentioned oxidized solid powder of part and 30~32 parts of distilled water investment three-necked flasks, will be mixed molten
Liquid is placed in a vacuum drying oven concentration, and high-intensitive antibacterial medical dressing is made.
The mass fraction of sodium hydroxide solution as described in step (1) is 3~5%, the bath temperature of water-bath is 95~
100 DEG C, the isothermal reaction time is 3~5h.
Frequency in sonic oscillation instrument described in step (2) is 30~33kHz, and duration of oscillation is 5~6h, four-hole boiling flask
For warming temperature to 80~90 DEG C, the heated at constant temperature time is 3~5h, and the temperature in baking oven is 110~120 DEG C.
The revolving speed of blender described in step (3) is 100~120r/min, and mixing time is 20~22h.
Magnetic agitation rotating speed described in step (4) is 300~400r/min, and the magnetic agitation time is 100~120min,
Vacuum degree in vacuum oven is 100~120Pa, temperature is 30~35 DEG C.
Vacuum degree in vacuum oven described in step (5) is 30~50Pa, temperature is 50~55 DEG C, concentration time
For 3~4h.
The method have the benefit that:
(1) garlic clove and Chinese aloe leaf chopping are placed on boiling in lye first by the present invention, and sodium citrate and glycerol are added after boiling
Hybrid reaction dries and reaction solid powder is made, sodium alginate soln and high iron acid sodium reaction are then generated mixed dispersion liquid,
Potassium chloride is added into mixed dispersion liquid again and propylene glycol carries out dialysis treatment and oxidized solid powder is made, finally by carboxymethyl shell
Glycan, reaction solid powder and the mixing of oxidized solid powder, are made high-intensitive antibacterial medical dressing after concentration, the present invention is by garlic clove
It is mixed in acid & alkali liquid high temperature boiling with Chinese aloe leaf, sodium citrate is added after boiling and glycerol is modified, is had in garlic clove big
Allicin ingredient has good bactericidal and bacteriostatic effect, has anthraquinones in Chinese aloe leaf, helps to repair wound while prevent
Infection, while sodium citrate and glycerol is added, allicin and Anthraquinones nutriment are modified, thus the substance that has additional nutrients
In the organo-functional groups quantity such as hydroxyl, carboxyl, carbonyl, covalent bond and intermolecular work can be formed with molecules other in dressing
It firmly adsorbs, makes to be more likely formed gel state between each ingredient, while can be improved the intensity of dressing, dressing is made to be difficult to be broken；
(2) iron ion is introduced into Aloe anthraquinones class and allicin nutritional ingredient in the present invention, passes through ionic bond and chelation
It is adsorbed in iron ion in nutriment, it is even closer that degree is bonded between each nutritional ingredient, while iron ion is released to wound
On mouth, may advantageously facilitate the contraction and healing of wound, and the plant fiber extracted from garlic clove and Chinese aloe leaf can with it is each
Microballoon state is formed between nutriment, makes to form a large amount of hole in medical dressing, is conducive to improve the ventilative of medical dressing
Rate helps wound healing, has broad application prospects.
Specific embodiment
Garlic clove is mixed with Chinese aloe leaf 5 ︰ 1 in mass ratio and is chopped into fritter investment beaker, is 3~5% with mass fraction
Sodium hydroxide solution impregnates garlic clove and Chinese aloe leaf, places the beaker in the water-bath that bath temperature is 95~100 DEG C, isothermal reaction
Filtrate is obtained by filtration after reaction in 3~5h；According to parts by weight, by 28~30 parts of above-mentioned filtrates, 1.0~1.3 parts of sodium citrates, 2
In~4 parts of glycerol and 11~14 parts of propylene glycol investment four-hole boiling flasks, four-hole boiling flask is put into sonic oscillation instrument, with 30~
Mixed liquor is made in 5~6h of hunting of frequency of 33kHz, and the iron chloride crystal powder of mixed liquor quality 3~5% is added into four-hole boiling flask
Four-hole boiling flask is warming up to 80~90 DEG C, 3~5h of heated at constant temperature by end, and heating is placed in baking oven, dry at 110~120 DEG C
To constant weight, reaction solid powder is made, it is spare；It puts into beaker and mixes after sodium alginate and distilled water 1 ︰ 50 in mass ratio are mixed
Uniformly obtained mixed solution is closed, the Na2Fe04 crystal powder of mixed solution quality 3.0~3.5% is added into beaker, by beaker
Under no light condition, 20~22h is mixed with the revolving speed of 100~120r/min with blender, mixed dispersion liquid is made；By weight
Number meter is measured, is weighed in 80~85 parts of above-mentioned mixed dispersion liquids, 4~6 parts of propylene glycol and 1~2 part of potassium chloride investment reaction kettle, with
Revolving speed 100~120min of magnetic agitation of 300~400r/min, is poured into bag filter after stirring, is made mixed after dialysis 2~3 days
Product is closed, mix products are placed in a vacuum drying oven, under conditions of vacuum degree is 100~120Pa, temperature is 30~35 DEG C
Drying is until oxidized solid powder is made in product constant weight；According to parts by weight, 2.0~2.5 parts of carboxymethyl chitosans, 3~4 are weighed
It is mixed in the spare reaction solid powder of part, 5~6 parts of above-mentioned oxidized solid powder and 30~32 parts of distilled water investment three-necked flasks
Mixed solution is placed in a vacuum drying oven vacuum degree is 30~50Pa, temperature is 50~55 DEG C by uniformly obtained mixed solution
Under conditions of 3~4h is concentrated, high-intensitive antibacterial medical dressing is made.
Example 1
Garlic clove is mixed with Chinese aloe leaf 5 ︰ 1 in mass ratio and is chopped into fritter investment beaker, the hydroxide for being 3% with mass fraction
Sodium solution impregnates garlic clove and Chinese aloe leaf, places the beaker in the water-bath that bath temperature is 95 DEG C, isothermal reaction 3h, mistake after reaction
Filter obtains filtrate；According to parts by weight, by 28 parts of above-mentioned filtrates, 1.0 parts of sodium citrates, 2 parts of glycerol and 11 parts of propylene glycol investments
In four-hole boiling flask, four-hole boiling flask is put into sonic oscillation instrument, mixed liquor is made with the hunting of frequency 5h of 30kHz, is burnt to four mouthfuls
The iron chloride crystal powder of mixed liquor quality 3% is added in bottle, four-hole boiling flask is warming up to 80 DEG C, heated at constant temperature 3h, heats postposition
It in baking oven, dries at 110 DEG C DEG C to constant weight, reaction solid powder is made, it is spare；Sodium alginate and distilled water are pressed into quality
It is uniformly mixed obtained mixed solution than putting into beaker after 1 ︰ 50 mixing, the high-speed rail of mixed solution quality 3.0% is added into beaker
Sour sodium crystal powder is mixed 20h with blender with the revolving speed of 100r/min, mixing is made by beaker under no light condition
Dispersion liquid；According to parts by weight, it weighs in 80 parts of above-mentioned mixed dispersion liquids, 4 parts of propylene glycol and 1 part of potassium chloride investment reaction kettle,
It with the revolving speed magnetic agitation 100min of 300r/min, is poured into bag filter after stirring, mix products is made after dialysis 2 days, will mix
Product is closed to be placed in a vacuum drying oven, it is dry under conditions of vacuum degree is 100Pa, temperature is 30 DEG C until product constant weight is made
Oxidized solid powder；According to parts by weight, weigh 2.0 parts of carboxymethyl chitosans, 3 parts of spare reaction solid powders, 5 parts it is above-mentioned
It is uniformly mixed obtained mixed solution in oxidized solid powder and 30 parts of distilled water investment three-necked flasks, mixed solution is placed in vacuum
3h is concentrated under conditions of vacuum degree is 30Pa, temperature is 50 DEG C in drying box, high-intensitive antibacterial medical dressing is made.
Example 2
Garlic clove is mixed with Chinese aloe leaf 5 ︰ 1 in mass ratio and is chopped into fritter investment beaker, the hydroxide for being 4% with mass fraction
Sodium solution impregnates garlic clove and Chinese aloe leaf, places the beaker in the water-bath that bath temperature is 97 DEG C, isothermal reaction 4h, mistake after reaction
Filter obtains filtrate；According to parts by weight, by 29 parts of above-mentioned filtrates, 1.3 parts of sodium citrates, 3 parts of glycerol and 13 parts of propylene glycol investments
In four-hole boiling flask, four-hole boiling flask is put into sonic oscillation instrument, mixed liquor is made with the hunting of frequency 5h of 31kHz, is burnt to four mouthfuls
The iron chloride crystal powder of mixed liquor quality 4% is added in bottle, four-hole boiling flask is warming up to 85 DEG C, heated at constant temperature 4h, heats postposition
It in baking oven, dries at 115 DEG C DEG C to constant weight, reaction solid powder is made, it is spare；Sodium alginate and distilled water are pressed into quality
It is uniformly mixed obtained mixed solution than putting into beaker after 1 ︰ 50 mixing, the high-speed rail of mixed solution quality 3.3% is added into beaker
Sour sodium crystal powder is mixed 21h with blender with the revolving speed of 110r/min, mixing is made by beaker under no light condition
Dispersion liquid；According to parts by weight, it weighs in 83 parts of above-mentioned mixed dispersion liquids, 5 parts of propylene glycol and 1 part of potassium chloride investment reaction kettle,
It with the revolving speed magnetic agitation 110min of 350r/min, is poured into bag filter after stirring, mix products is made after dialysis 2 days, will mix
Product is closed to be placed in a vacuum drying oven, it is dry under conditions of vacuum degree is 110Pa, temperature is 33 DEG C until product constant weight is made
Oxidized solid powder；According to parts by weight, weigh 2.3 parts of carboxymethyl chitosans, 3 parts of spare reaction solid powders, 5 parts it is above-mentioned
It is uniformly mixed obtained mixed solution in oxidized solid powder and 31 parts of distilled water investment three-necked flasks, mixed solution is placed in vacuum
3h is concentrated under conditions of vacuum degree is 40Pa, temperature is 53 DEG C in drying box, high-intensitive antibacterial medical dressing is made.
Example 3
Garlic clove is mixed with Chinese aloe leaf 5 ︰ 1 in mass ratio and is chopped into fritter investment beaker, the hydroxide for being 5% with mass fraction
Sodium solution impregnates garlic clove and Chinese aloe leaf, places the beaker in the water-bath that bath temperature is 100 DEG C, isothermal reaction 5h, after reaction
Filtrate is obtained by filtration；According to parts by weight, 30 parts of above-mentioned filtrates, 1.3 parts of sodium citrates, 4 parts of glycerol and 14 parts of propylene glycol are thrown
Enter in four-hole boiling flask, four-hole boiling flask is put into sonic oscillation instrument, mixed liquor, Xiang Sikou are made with the hunting of frequency 6h of 33kHz
The iron chloride crystal powder of mixed liquor quality 5% is added in flask, four-hole boiling flask is warming up to 90 DEG C, heated at constant temperature 5h, after heating
It is placed in baking oven, is dried at 120 DEG C DEG C to constant weight, reaction solid powder is made, it is spare；Sodium alginate and distilled water are pressed into matter
Amount is uniformly mixed obtained mixed solution than putting into beaker after 1 ︰ 50 mixing, and the height of mixed solution quality 3.5% is added into beaker
Sodium ferrite crystal powder is mixed 22h with blender with the revolving speed of 120r/min, is made mixed by beaker under no light condition
Close dispersion liquid；According to parts by weight, 85 parts of above-mentioned mixed dispersion liquids, 6 parts of propylene glycol and 2 parts of potassium chloride investment reaction kettles are weighed
In, it with the revolving speed magnetic agitation 120min of 400r/min, is poured into bag filter after stirring, mix products is made after dialysis 3 days, it will
Mix products are placed in a vacuum drying oven, dry until product constant weight system under conditions of vacuum degree is 120Pa, temperature is 35 DEG C
Obtain oxidized solid powder；According to parts by weight, 2.5 parts of carboxymethyl chitosans, 4 parts of spare reaction solid powders are weighed, on 6 parts
It states in oxidized solid powder and 32 parts of distilled water investment three-necked flasks and is uniformly mixed obtained mixed solution, mixed solution is placed in very
4h is concentrated under conditions of vacuum degree is 50Pa, temperature is 55 DEG C in empty drying box, high-intensitive antibacterial medical dressing is made.
Comparative example
With Shanghai City company production medical dressing as a comparison case to the antibacterial medical dressing of high intensity produced by the present invention with
Medical dressing in comparative example is detected, and testing result is as shown in table 1:
Water vapour permeability test
It is tested according to standard ASTME96-20106.
Anti-microbial property test
According to GB/T20944.3-2008 " the evaluation third portion of antibacterial textile performance: succusion ", Staphylococcus aureus is tested
Bacterium (ATCC6538), Candida albicans (ACTT10231), Escherichia coli (ATCC25922) three kinds of strains bacteriostasis rate.
1 performance measurement result of table
According to data in table 1 it is found that the antibacterial medical dressing of high intensity produced by the present invention, not only intensity is high, good permeability, moreover it is possible to
Enough long-acting bacteriostatics, isolation infection are a kind of highly-safe Novel nursing materials, have good market prospects.
Claims (6)
1. a kind of preparation method of the antibacterial medical dressing of high intensity, it is characterised in that specific preparation step are as follows:
(1) garlic clove is mixed with Chinese aloe leaf 5 ︰ 1 in mass ratio and is chopped into fritter investment beaker, impregnate garlic with sodium hydroxide solution
Valve and Chinese aloe leaf place the beaker isothermal reaction in water-bath, filtrate are obtained by filtration after reaction；
(2) according to parts by weight, by 28~30 parts of above-mentioned filtrates, 1.0~1.3 parts of sodium citrates, 2~4 parts of glycerol and 11~14
In part propylene glycol investment four-hole boiling flask, four-hole boiling flask is put into sonic oscillation instrument and vibrates obtained mixed liquor, into four-hole boiling flask
The iron chloride crystal powder of mixed liquor quality 3~5% is added, four-hole boiling flask is heated up, heated at constant temperature, heating is placed in baking oven
To constant weight, obtained reaction solid powder is spare for drying；
(3) it is put into after mixing sodium alginate and distilled water 1 ︰ 50 in mass ratio in beaker and is uniformly mixed obtained mixed solution, to
The Na2Fe04 crystal powder that mixed solution quality 3.0~3.5% is added in beaker uses blender by beaker under no light condition
It is mixed, mixed dispersion liquid is made；
(4) according to parts by weight, 80~85 parts of above-mentioned mixed dispersion liquids, 4~6 parts of propylene glycol and 1~2 part of potassium chloride investment are weighed
In reaction kettle, magnetic agitation is carried out, is poured into bag filter after stirring, mix products is made after dialysis 2~3 days, by mix products
It is placed in a vacuum drying oven dry until oxidized solid powder is made in product constant weight；
(5) according to parts by weight, 2.0~2.5 parts of carboxymethyl chitosans, 3~4 parts of spare reaction solid powders, 5~6 are weighed
It is uniformly mixed obtained mixed solution in the above-mentioned oxidized solid powder of part and 30~32 parts of distilled water investment three-necked flasks, will be mixed molten
Liquid is placed in a vacuum drying oven concentration, and high-intensitive antibacterial medical dressing is made.
2. a kind of preparation method of antibacterial medical dressing of high intensity according to claim 1, it is characterised in that: step (1)
Described in the mass fraction of sodium hydroxide solution be 3~5%, the bath temperature of water-bath is 95~100 DEG C, when isothermal reaction
Between be 3~5h.
3. a kind of preparation method of antibacterial medical dressing of high intensity according to claim 1, it is characterised in that: step (2)
Described in sonic oscillation instrument in frequency be 30~33kHz, duration of oscillation be 5~6h, four-hole boiling flask warming temperature to 80~
90 DEG C, the heated at constant temperature time is 3~5h, and the temperature in baking oven is 110~120 DEG C.
4. a kind of preparation method of antibacterial medical dressing of high intensity according to claim 1, it is characterised in that: step (3)
Described in blender revolving speed be 100~120r/min, mixing time be 20~22h.
5. a kind of preparation method of antibacterial medical dressing of high intensity according to claim 1, it is characterised in that: step (4)
Described in magnetic agitation rotating speed be 300~400r/min, the magnetic agitation time is 100~120min, in vacuum oven
Vacuum degree is 100~120Pa, temperature is 30~35 DEG C.
6. a kind of preparation method of antibacterial medical dressing of high intensity according to claim 1, it is characterised in that: step (5)
Described in vacuum oven in vacuum degree be 30~50Pa, temperature is 50~55 DEG C, concentration time be 3~4h.
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