CN109125782A - A kind of porous fibre/inorganic bio Particles dispersed type skin wound dressing and preparation method thereof - Google Patents
A kind of porous fibre/inorganic bio Particles dispersed type skin wound dressing and preparation method thereof Download PDFInfo
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- CN109125782A CN109125782A CN201810828630.6A CN201810828630A CN109125782A CN 109125782 A CN109125782 A CN 109125782A CN 201810828630 A CN201810828630 A CN 201810828630A CN 109125782 A CN109125782 A CN 109125782A
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- skin wound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
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- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Textile Engineering (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of porous fibre/inorganic bio Particles dispersed type skin wound dressing and preparation method thereof, belong to biomedical materials field.The material is main raw material(s) with the particle for promoting wound healing by adding in the high molecular polymer with biocompatibility, and by adding corresponding pore creating material, obtained using method of electrostatic spinning.The dressing being prepared has huge specific surface area and pore structure, porous structure in fiber, enable granular materials to collagen and various albumen relevant with Wound treating, growth factor are adsorbed in body fluid contact process, to build the microenvironment of a suitable cell adherence, migration and proliferation, accelerate collagen deposition and angiogenesis, thus wound healing process.Porous fibre of the invention/inorganic bio Particles dispersed type skin wound dressing preparation method is simple and easy, has good safety and preferable mechanical performance while guaranteeing skin repair performance, can be used for Wound treating.
Description
Technical field
The invention belongs to biomedical material technologies, and in particular to a kind of porous fibre/inorganic bio particle
Compound skin wound dressing and preparation method thereof.
Background technique
Wound dressing can play the protection surface of a wound, prevent body fluid and protein-loss, prevent bacterium from invading, while can be with
Support spatially and stimulation physiologically are provided to various cells relevant to reparation.Ideal material should have following spy
Point: good biocompatibility has certain mechanical strength without apparent rejection and inflammatory reaction, can resist certain
Structural stress to organize supporting role to part；Biological medical polymer material used can be non-degradable material
Or degradation material, the latter should have suitable degradation speed, and catabolite must be nontoxic, can be absorbed or is discharged in time
In vitro；It is good with histiocytic compatibility.But for example self skin heterodermic graft of current main skin repair product, artificial auxiliary material
And tissue engineering skin due to antigen-reactive, it is expensive the disadvantages of, can not be applied on a large scale in all kinds of skin injuries treat,
The especially serious patient's treatment of defect of skin.
Studies have shown that the particle with high bioactivity and biocompatibility, such as bio-vitric and calcium phosphate ceramic, energy
The microenvironment for being conducive to cell adherence, migration and proliferation is enough built, accelerates collagen deposition and angiogenesis, to promote skin
The regeneration of the soft tissues such as skin.Based on the above research, foreign countries develop in recent years repairs for acute and chronic skin wound and mucosal ulcer
Multiple product, for treating the diseases such as skin trauma, burn, canker sore and Diabetic Skin Ulcer in clinic.
Although traditional fibrous framework has good mechanical performance, can provide the environment of migration and proliferation to cell,
But lack the effect of wound healing.And bracket or powder made of particle completely, then lack dermal scaffold material
Expect the mechanical performances such as desired extension and stretching.In addition, if only simply adding the particles in fibrous framework, particle meeting
It is completely wrapped in fibrous inside, the formation of the final microenvironment for hindering to promote wound healing.Therefore, this patent passes through in Static Spinning
Pore creating material is introduced in silk solution, porous structure is formed in fiber surface, to prepare a kind of porous fibre/inorganic bio
Particles dispersed type skin wound dressing, not only can be to avoid the two the shortcomings that, moreover it is possible to the advantages of the two be combined, developed
A kind of existing good mechanical performance, but also with the novel skin dressing for promoting wound healing ability.
Summary of the invention
In order to solve the problems in the existing technology, the primary purpose of the present invention is that provide a kind of porous fibre/
The preparation method of inorganic bio Particles dispersed type skin wound dressing has on the fiber being prepared by this method more
Pore structure.
It is another object of the present invention to provide the porous fibre prepared by the above method/inorganic bio particles
Compound skin wound dressing, which has good mechanical performance and biocompatibility, while can promote the surface of a wound again
Quickly healing.
The purpose of the present invention is implemented with the following technical solutions.
A kind of preparation method of porous fibre/inorganic bio Particles dispersed type skin wound dressing, including following step
It is rapid:
(1) particle, high molecular polymer and pore creating material are successively added in organic solvent, after stirring becomes sticky to solution, are surpassed
The further discrete particles of sound, are stirred for, and obtain finely dispersed viscous solution；
(2) viscous solution that step (1) obtains is placed in the syringe pump connecting with high-pressure installation, the use of roller is to receive dress
It sets, is 8cm-20cm receiving distance, drum rotation speed 200-800rpm, injection pump rate is 0.5-2ml/h, voltage 8-
Spinning under 25kv obtains porous fibre/inorganic bio Particles dispersed type skin wound dressing；
(3) porous fibre/inorganic bio Particles dispersed type skin wound dressing is placed in draught cupboard, then packaging disappears
Poison.
Preferably, step (1) described particle include but is not limited to bio-vitric, calcium phosphate, calcium silicates, dicalcium silicate etc. can
For the inorganic particulate material of skin repair, the partial size of the particle is 100nm-10 μm.
Preferably, step (1) high molecular polymer is polylactic acid, polycaprolactone, poly lactic-co-glycolic acid copolymerization
The mixing of one or more of object, poly lactic-co-glycolic acid-caprolactone copolymer, type i collagen, gelatin and chitosan
Object.
Preferably, step (1) pore creating material is one or more of dimethyl sulfoxide and n,N-Dimethylformamide.
Preferably, it is 4h-24h that step (1) stirring to solution, which becomes the sticky time used,；The time of the ultrasound is
Half an hour.
Preferably, the time of step (2) described spinning is 0.5-24h.
Preferably, porous fibre/inorganic bio Particles dispersed type skin wound dressing obtained by step (2) with a thickness of
20-500μm。
Preferably, porous fibre/inorganic bio Particles dispersed type skin wound dressing obtained by step (2) has porous
Structure, fibre diameter are 500nm-20 μm, and the bore dia on fiber is 10nm-2 μm.
Preferably, the time of step (3) described placement is 2-7 days.
A kind of porous fibre/inorganic bio Particles dispersed type skin wound as made from above-described preparation method
Dressing, the dressing is using inorganic particle and high molecular polymer with good biological activity and bio-safety performance as matrix material
Material.
Above-described porous fibre/inorganic bio Particles dispersed type skin wound dressing is used for Wound treating.
Compared with prior art, the present invention has the following beneficial effects:
1. porous fibre provided by the invention/inorganic bio Particles dispersed type skin wound dressing has porous structure, energy
Enough in surface enrichment collagen and various albumen relevant to Wound treating and growth factor, it is convenient for cell adherence, migration and increasing
It grows, accelerates collagen deposition and angiogenesis, to promote wound healing；
2. the high molecular polymer that the present invention selects has good biocompatibility,；
3. the present invention prepares material using electrostatic spinning technique, easy to operate, it is conducive to mass production；
4. material produced by the present invention has good porosity and excellent mechanical performance, it can be applied to the large area surface of a wound and lack
The treatment of damage.
Detailed description of the invention
Fig. 1 is in embodiment 1 using porous fibre/inorganic bio Particles dispersed type skin of method of electrostatic spinning preparation
The scanning electron microscope (SEM) photograph of Wound dressing；
Fig. 2 is porous fibre in embodiment 1/inorganic bio Particles dispersed type skin wound dressing distribution of fiber diameters
Figure.
Fig. 3 is in embodiment 2 using porous fibre/inorganic bio Particles dispersed type skin of method of electrostatic spinning preparation
The scanning electron microscope (SEM) photograph of Wound dressing；
Fig. 4 is porous fibre in embodiment 2/inorganic bio Particles dispersed type skin wound dressing distribution of fiber diameters
Figure.
Fig. 5 is in embodiment 3 using porous fibre/inorganic bio Particles dispersed type skin of method of electrostatic spinning preparation
The scanning electron microscope (SEM) photograph of Wound dressing；
Fig. 6 is porous fibre in embodiment 3/inorganic bio Particles dispersed type skin wound dressing distribution of fiber diameters
Figure.
Specific embodiment
The present invention is further explained below with reference to examples and drawings, embodiments of the present invention are not limited thereto.
Embodiment 1
(1) by 0.2g bioglass particles (partial size is 100nm-10 μm), 0.625g polycaprolactone and 0.75mL dimethyl sulfoxide
It is successively added 4mL chloroform and 0.25mLN, in the mixed solution of dinethylformamide, 12h is stirred at room temperature, becomes viscous to solution
After thick, ultrasonic half an hour further disperses bioglass particles, is stirred for 4h, obtains finely dispersed viscous solution.
(2) viscous solution that step (1) obtains is placed in the syringe pump connecting with high-pressure installation, the use of roller is to receive
Device, receiving distance is 15cm, and drum rotation speed 200rpm, injection pump rate is 0.5ml/h, and voltage 12kv, spinning 2h are obtained
With a thickness of 100 μm of polycaprolactone porous compound skin wound dressing of fiber/bioglass particles, gained dressing has porous knot
Structure, fibre diameter are 500nm-2 μm, and the bore dia on fiber is 10nm-500nm.
(3) film is placed at room temperature for 2 days in draught cupboard, package sterilization.
It can be seen that average fibre diameter in 1372nm from Fig. 1 and Fig. 2, and fibre diameter is mainly distributed on 1200nm
To between 1600nm.Fiber size is more uniform.
Embodiment 2
(1) by 0.3g bioglass particles (partial size is 100nm-10 μm), 0.625g polycaprolactone and 0.75mL dimethyl sulfoxide
It is successively added 4mL chloroform and 0.25mLN, in the mixed solution of dinethylformamide, 12h is stirred at room temperature, becomes viscous to solution
After thick, ultrasonic half an hour further disperses bioglass particles, is stirred for 4h, obtains finely dispersed viscous solution.
(2) viscous solution that step (1) obtains is placed in the syringe pump connecting with high-pressure installation, the use of roller is to receive
Device, receiving distance is 15cm, and drum rotation speed 200rpm, injection pump rate is 0.5ml/h, and voltage 12kv, spinning 2h are obtained
With a thickness of 100 μm of polycaprolactone porous compound skin wound dressing of fiber/bioglass particles, gained dressing has porous knot
Structure, fibre diameter are 500nm-2 μm, and the bore dia on fiber is 10nm-500nm.
(3) film is placed at room temperature for 2 days in draught cupboard, package sterilization.
From figs. 3 and 4 it can be seen that average fibre diameter is in 1421nm, and fibre diameter is mainly distributed on 1200nm
To between 1600nm.Fiber size is more uniform.
Embodiment 3
(1) by 0.4g bioglass particles (partial size is 100nm-10 μm), 0.625g polycaprolactone and 0.75mL dimethyl sulfoxide
It is successively added 4mL chloroform and 0.25mLN, in the mixed solution of dinethylformamide, 12h is stirred at room temperature, becomes viscous to solution
After thick, ultrasonic half an hour further disperses bioglass particles, is stirred for 4h, obtains finely dispersed viscous solution.
(2) viscous solution that step (1) obtains is placed in the syringe pump connecting with high-pressure installation, the use of roller is to receive
Device, receiving distance is 15cm, and drum rotation speed 200rpm, injection pump rate is 0.5ml/h, and voltage 12kv, spinning 2h are obtained
With a thickness of 100 μm of polycaprolactone porous compound skin wound dressing of fiber/bioglass particles, gained dressing has porous knot
Structure, fibre diameter are 500nm-2 μm, and the bore dia on fiber is 10nm-500nm.
(3) film is placed at room temperature for 2 days in draught cupboard, package sterilization.
From figs. 5 and 6, it can be seen that average fibre diameter is in 1443nm, and fibre diameter is mainly distributed on 1200nm
To between 1600nm.Fiber size is more uniform.
Claims (10)
1. a kind of porous fibre/inorganic bio Particles dispersed type skin wound dressing preparation method, which is characterized in that packet
Include following steps:
(1) particle, high molecular polymer and pore creating material are successively added in organic solvent, after stirring becomes sticky to solution, are surpassed
The further discrete particles of sound, are stirred for, and obtain finely dispersed viscous solution；
(2) viscous solution that step (1) obtains is placed in the syringe pump connecting with high-pressure installation, the use of roller is to receive dress
It sets, is 8cm-20cm receiving distance, drum rotation speed 200-800rpm, injection pump rate is 0.5-2ml/h, voltage 8-
Spinning under 25kv obtains porous fibre/inorganic bio Particles dispersed type skin wound dressing；
(3) porous fibre/inorganic bio Particles dispersed type skin wound dressing is placed in draught cupboard, then packaging disappears
Poison.
2. inorganic bio particle according to claim 1, which is characterized in that step (1) particle is bio-vitric, phosphorus
One of sour calcium, calcium silicates and dicalcium silicate are a variety of；The partial size of the particle is 100nm-10 μm.
3. preparation method according to claim 1, which is characterized in that step (1) high molecular polymer is polylactic acid, gathers oneself
Lactone, poly lactide-glycolide acid, poly lactic-co-glycolic acid-caprolactone copolymer, type i collagen, gelatin and chitosan
One or more of mixture.
4. preparation method according to claim 1, which is characterized in that step (1) pore creating material is dimethyl sulfoxide and N, N-
One or more of dimethylformamide.
5. preparation method according to claim 1, which is characterized in that step (1) stirring to solution becomes sticky institute's used time
Between be 4h-24h；The time of the ultrasound is half an hour.
6. preparation method according to claim 1, which is characterized in that the time of step (2) described spinning is 0.5-24h.
7. preparation method according to claim 1, which is characterized in that porous fibre/inorganic bio particle obtained by step (2)
Compound skin wound dressing with a thickness of 20-500 μm.
8. preparation method according to claim 1, which is characterized in that porous fibre/inorganic bio particle obtained by step (2)
Compound skin wound dressing has porous structure, and fibre diameter is 500nm-20 μm, and the bore dia on fiber is 10nm-2 μm.
9. preparation method according to claim 1, which is characterized in that the time of step (3) described placement is 2-7 days.
10. a kind of porous fibre/inorganic bio particle as made from the described in any item preparation methods of claim 1-9 is answered
Mould assembly skin wound dressing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810828630.6A CN109125782A (en) | 2018-07-25 | 2018-07-25 | A kind of porous fibre/inorganic bio Particles dispersed type skin wound dressing and preparation method thereof |
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| CN201810828630.6A CN109125782A (en) | 2018-07-25 | 2018-07-25 | A kind of porous fibre/inorganic bio Particles dispersed type skin wound dressing and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110180013A (en) * | 2019-05-31 | 2019-08-30 | 上海纳米技术及应用国家工程研究中心有限公司 | Overlay film type medical burn prevents adhesion the preparation method and products thereof and application of type gauze bandage |
| CN111744049A (en) * | 2020-06-12 | 2020-10-09 | 广东工贸职业技术学院 | Preparation method of wound repair material with cell growth regulation function |
| CN114272443A (en) * | 2021-12-10 | 2022-04-05 | 中国科学院上海硅酸盐研究所 | Preparation method and application of zinc silicate nanoparticle composite fiber scaffold |
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| CN104096261A (en) * | 2013-04-09 | 2014-10-15 | 上海交通大学医学院附属第九人民医院 | Gelatin / mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof |
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2018
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| CN104096261A (en) * | 2013-04-09 | 2014-10-15 | 上海交通大学医学院附属第九人民医院 | Gelatin / mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110180013A (en) * | 2019-05-31 | 2019-08-30 | 上海纳米技术及应用国家工程研究中心有限公司 | Overlay film type medical burn prevents adhesion the preparation method and products thereof and application of type gauze bandage |
| CN111744049A (en) * | 2020-06-12 | 2020-10-09 | 广东工贸职业技术学院 | Preparation method of wound repair material with cell growth regulation function |
| CN111744049B (en) * | 2020-06-12 | 2021-11-05 | 广东工贸职业技术学院 | Preparation method of wound repair material with cell growth regulation function |
| CN114272443A (en) * | 2021-12-10 | 2022-04-05 | 中国科学院上海硅酸盐研究所 | Preparation method and application of zinc silicate nanoparticle composite fiber scaffold |
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Application publication date: 20190104 |