CN107761252A - A kind of bioactivity glass composite nano-fiber membrane and preparation method thereof - Google Patents
A kind of bioactivity glass composite nano-fiber membrane and preparation method thereof Download PDFInfo
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- CN107761252A CN107761252A CN201711239072.1A CN201711239072A CN107761252A CN 107761252 A CN107761252 A CN 107761252A CN 201711239072 A CN201711239072 A CN 201711239072A CN 107761252 A CN107761252 A CN 107761252A
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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- Animal Behavior & Ethology (AREA)
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Abstract
The invention discloses a kind of bioactivity glass composite nano-fiber membrane and preparation method thereof, belong to bio-medical composition field.This method chooses the main component in Skin Cell epimatrix and the bioactivity glass with good biocompatibility and bioactivity as material, using electrostatic spinning technique, by controlling different technical parameters, is rotated using high speed（The 3000rpm of rotating speed 500）Roller, horizontal positioned parallel-plate electrode be receiver, or using near field electrostatic spinning machine the methods of, prepare bioactivity glass composite nano-fiber membrane.The preparation method of the present invention is simple and easy, and the nano fibrous membrane prepared has good biocompatibility and biomechanical strength, can accelerate the Healing Rate of wound surface in refractory to treatment, has preferable application prospect in terms of skin wound dressing.
Description
Technical field
The present invention relates to method of electrostatic spinning to prepare inorganic-technical field of polymer composite materials, and in particular to a kind of biology
Activity glass composite nano-fiber membrane and preparation method thereof.
Background technology
As human living standard improves constantly, requirement of the people to skin wound treatment also more and more higher.Current full generation
Boundary is up to 40,000,000 people by the patient that skin acute and chronic wound perplexs.China is every year by burn and scald, traffic accident, diabetes etc.
Caused by skin trauma influence number surpass 10,000,000 people, its caused medical expense is more than 60,000,000,000 yuan.It is but domestic at present
Not yet develop the preferable skin ultrastructure material for meeting clinical demand outside.Due to pressure ulcer, varication, blood
Ulcer caused by Guan Yan, diabetes etc., in the presence of multifactor（Such as malnutrition, perfused tissue is bad and ischemia-reperfusion
Damage, bacterial load, infection and slough retain, and organize high glucose load, cell ageing etc.）, the surface of a wound is difficult to repair, to skin
Barrier function and outward appearance cause to have a strong impact on, and may cause disorderly general metabolism, infection or even the life for threatening patient.Tradition
The treatment of means to wound surface in refractory to treatment such as the treatment of debridement wrapping, wound depression and underlying pathology of Wound treating technology not
Enough ideals.
In recent years, preparing Wound dressing by electrostatic spinning technique becomes new one big focus of clinical research.Static Spinning
The principle of silk is to make solution powered on polymer solution high-voltage load, and taper drop is formed in electrospinning syringe needle end；Work as liquid
When the charge repulsion on drop surface exceedes its surface tension, drop sprays at a high speed in the presence of forceful electric power field force forms small jet,
And it is received by the receiver to form micro nanometer fiber in the presence of the conditions such as electric field force stretching, solvent volatilization.Pass through electrostatic spinning
The micro nanometer fiber of preparation has following feature：（1）Tunica fibrosa porosity is higher, can both keep the good permeability of the surface of a wound,
Promote the respiration of surface of a wound cell；（2）Micro/nano fiber structure has very high specific surface area, can be as good medicine
Carry carrier；（3）Electrospinning material can carry out surface-functionalized processing, realize more multi-functional.（4）It is thin that composite fibre can imitate skin
The composition and structure of extracellular matrix, are more beneficial for the reparation of the surface of a wound.
Polycaprolactone has good biocompatibility and mechanical property, added poly- as a kind of synthesis high polymer material
Caprolactone can improve the intensity of composite fibre, it is met clinical requirement when as Wound dressing.Collagenous fibres are as a kind of
The main component of extracellular matrix, three-dimensional microenvironment is provided for Skin Cell, and pass through the interaction with extracellular matrix
Regulate and control the behavior of Skin Cell.
An important branch of the bioactivity glass as lithotroph medical material, has good biocompatibility,
Have no toxic side effect, bone is fast into key speed, and the growth of bone tissue can be stimulated in bone-implantation body interface.Due to bioactivity glass
Glass clinically excellent therapeutic effect, the attention rate more and more higher that people are studied bioactivity glass, the conjunction of bio-vitric
It is also more and more into method.Recent studies indicate that bioactivity glass not only has good Bone Defect Repari performance while also can
And the good combination of soft tissue, promotes the regeneration of skin histology.
Micro-nano bioactivity glass, polycaprolactone, collagen are used in mixed way electrostatic spinning technique and prepare composite cellulosic membrane,
The anti-inflammatory, antibacterial and good bioactivity of bioactivity glass are taken full advantage of, make use of the good biology of collagen
Compatibility, and by polycaprolactone improve composite mechanical property and too fast collagen degradation the problem of.Pass through electrostatic spinning
Nano-composite fiber film prepared by technology, has the characteristics that high-specific surface area, high porosity, so as to obtain the new of premium properties
Wound dressing.
The content of the invention
It is an object of the invention to the good mechanical property of the good biocompatibility of incorporating collagen, polycaprolactone and life
A kind of good bioactivity of thing activity glass, there is provided bioactivity glass composite nano-fiber membrane and preparation method thereof.
The present invention is achieved through the following technical solutions.
A kind of preparation method of bioactivity glass composite nano-fiber membrane, comprises the following steps：
（1）By polycaprolactone, collagenolysis in hexafluoroisopropanol, then nano-bioactive glass powder is added, stirring makes powder
Body is scattered to be suspended in solution, obtains electrostatic spinning solution；
（2）By step（1）The electrostatic spinning solution of gained is added in the injection device of electrospinning device, passes through electrostatic spinning
Method prepare composite cellulosic membrane；
（3）To step（2）The composite cellulosic membrane of gained obtains bioactivity glass composite Nano fibre after carrying out vacuum drying treatment
Tie up film, i.e. polycaprolactone-collagen-bioactivity glass composite micro-nano rice tunica fibrosa.
Preferably, step（1）The number-average molecular weight of described polycaprolactone is 50000-120000.
Preferably, step（1）The chemical composition of described nano-bioactive glass powder is with CaO-P2O5-SiO2Three
Based on metasystem, wherein, SiO2Mass percent be 40-80%, P2O5Mass percent be 1-20%, CaO quality percentage
Than for 10-40%.
Preferably, step（1）The mass volume ratio of the polycaprolactone and electrostatic spinning solution be 0.04-0.12 g/
ml；The mass volume ratio of the collagen and electrostatic spinning solution is 0.04-0.08 g/ml.
Preferably, step（1）Mass volume ratio of the nano-bioactive glass powder in electrostatic spinning solution be
0.02 - 0.04 g /ml。
Preferably, step（2）In, method of electrostatic spinning, refer to stretch in high voltage electric field by electropolymer drop, it is molten
Agent volatilizees to form fiber and using the method for flat receiver reception.
Preferably, step（2）Technological parameter is voltage 14-16kV, the μ of injection speed 15 used by the method for electrostatic spinning
L/min, the distance of needle point to receiver is 15-20cm；The receiver is roller or flat receiver, the rotating speed of the roller
For 5-15rpm.
Preferably, step（2）The electrospinning device includes injection device, voltage-operated device, the pin of flow-controllable
Head, reception device, temperature humidity control device and ventilation unit.
Preferably, step（2）Syringe needle internal diameter is 0.1-1mm used by the electrospinning device, is flat mouth at needle point.
Preferably, step（2）The temperature of described electrostatic spinning is 30-40 DEG C, relative humidity 20-80%.
Preferably, step（1）The time of the stirring is 12h.
Preferably, step（3）Described vacuum drying temperature is 40 DEG C.
A kind of bioactivity glass composite nano-fiber membrane as made from above-described preparation method.
Compared with current material, the invention has the advantages that and effect：
（1）The present invention takes full advantage of the height of bioactivity glass by composite collagen, polycaprolactone and bioactivity glass
Bioactivity, it is prepared for a kind of preferably skin wound dressing.
（2）It is fine as raw material, composite Nano of the present invention using the main component of natural skin extracellular matrix
Dimension film has good biocompatibility.
（3）The composite nano-fiber membrane that the present invention is prepared by electrostatic spinning technique make use of the anti-inflammatory of bioactivity glass
The characteristics such as disease, antibacterial, the problems such as effectively having completely cut off surgical procedure and the entrance of postoperative bacterium and infected.
（4）The preparation method is simple and easy, and raw material resources enriches, and easily realizes industrialized production.
Brief description of the drawings
Fig. 1 is bioactivity glass/polycaprolactone/collagen composite nano tunica fibrosa that the embodiment of the present invention 1 obtains；
Fig. 2 is bioactivity glass/polycaprolactone/collagen composite nano tunica fibrosa that the embodiment of the present invention 2 obtains；
Fig. 3 is bioactivity glass/polycaprolactone/collagen composite nano tunica fibrosa that the embodiment of the present invention 3 obtains.
Embodiment
With reference to specific embodiment, the present invention is further explained, but specific embodiment is not to this hair
Bright to be limited in any way, the implementation of the present invention is not limited to this.
Embodiment 1
0.2gPCL is weighed with electronic balance（Number-average molecular weight is 50000）, 0.2gI Collagen Type VIs and 0.2g58s bioactivity glass
Glass, it is dissolved in 5ml hexafluoroisopropanols, obtains the solution that mass volume ratio concentration is 0.12 g/ml, by solution magnetic at normal temperatures
Power stirring 12h dissolvings are complete, start electrostatic spinning after standing 5min；The parameter of electrostatic spinning is：Electrostatic potential 14kV, needle point arrive
The distance 12cm of receiver, the μ L/min of spinning speed 5, relative humidity 50%, temperature are 35 DEG C, and used syringe needle internal diameter is 0.5
Mm, it is flat mouth at needle point.Received using flat receiver, obtained after 40 DEG C of vacuum drying treatments bioactivity glass/gather oneself in
Ester/collagen composite nano tunica fibrosa.The scanning electron microscope (SEM) photograph of the bioactivity glass/polycaprolactone composite nanometer fiber membrane such as Fig. 1
Shown, as shown in Figure 1, bioactivity glass uniform load obtains the nanofiber in nanofiber, and by mechanics characterization
The tensile strength of film is 1.74 ± 0.31Mpa, meets the mechanical property needed for Wound dressing；Experiment in vitro proves the nanofiber
The propagation of people's dermal fibroblasts can be promoted.
Embodiment 2
0.6gPCL is weighed with electronic balance（Number-average molecular weight is 80000）, 0.4gI Collagen Type VIs and 0.1g58s bioactivity glass
Glass, it is dissolved in 5ml hexafluoroisopropanols, obtains the solution that mass volume ratio concentration is 0.22 g/ml, by solution magnetic at normal temperatures
Power stirring 12h dissolvings are complete, start electrostatic spinning after standing 5min；The parameter of electrostatic spinning is：Electrostatic potential 15kV, needle point arrive
The distance 15cm of receiver, the μ L/min of spinning speed 10, relative humidity 20%, temperature are 30 DEG C, and used syringe needle internal diameter is
1mm, it is flat mouth at needle point.Received using flat receiver, obtained after 40 DEG C of vacuum drying treatments bioactivity glass/gather oneself in
Ester/collagen composite nano tunica fibrosa.The scanning electron microscope (SEM) photograph of the bioactivity glass/polycaprolactone/collagen composite nano tunica fibrosa
As shown in Fig. 2 as shown in Figure 2, bioactivity glass uniform load obtains the nanometer in nanofiber, and by mechanics characterization
The tensile strength of tunica fibrosa is 2.14 ± 0.39Mpa, meets the mechanical property needed for Wound dressing；Experiment in vitro proves the nanometer
Fiber can promote the propagation of people's dermal fibroblasts.
Embodiment 3
0.4gPCL is weighed with electronic balance（Number-average molecular weight is 120000）, 0.3gI Collagen Type VIs and 0.15g58s bioactivity glass
Glass, it is dissolved in 5ml hexafluoroisopropanols, obtains the solution that mass volume ratio concentration is 0.17 g/ml, by solution magnetic at normal temperatures
Power stirring 12h dissolvings are complete, start electrostatic spinning after standing 5min；The parameter of electrostatic spinning is：Electrostatic potential 16kV, needle point arrive
The distance 20cm of receiver, the μ L/min of spinning speed 20, relative humidity 80%, temperature are 40 DEG C, and used syringe needle internal diameter is
0.1mm, it is flat mouth at needle point.Received using roller receiver, obtained after 40 DEG C of vacuum drying treatments bioactivity glass/gather oneself
Lactone/collagen composite nano tunica fibrosa.The ESEM of the bioactivity glass/polycaprolactone/collagen composite nano tunica fibrosa
Figure is as shown in figure 3, bioactivity glass uniform load obtains the nano fibrous membrane in nanofiber, and by mechanics characterization
Tensile strength is 2.14 ± 0.39Mpa, meets the mechanical property needed for Wound dressing；Experiment in vitro proves that the nanofiber can promote
Enter the propagation of people's dermal fibroblasts.
Claims (10)
1. a kind of preparation method of bioactivity glass composite nano-fiber membrane, it is characterised in that comprise the following steps：
（1）By polycaprolactone, collagenolysis in hexafluoroisopropanol, then nano-bioactive glass powder is added, stirring makes powder
Body is scattered to be suspended in solution, obtains electrostatic spinning solution；
（2）By step（1）The electrostatic spinning solution of gained is added in the injection device of electrospinning device, passes through electrostatic spinning
Method prepare composite cellulosic membrane；
（3）To step（2）The composite cellulosic membrane of gained obtains bioactivity glass composite Nano fibre after carrying out vacuum drying treatment
Tie up film, i.e. polycaprolactone-collagen-bioactivity glass composite micro-nano rice tunica fibrosa.
2. preparation method according to claim 1, it is characterised in that step（1）The equal molecule of number of described polycaprolactone
Measure as 50000-120000.
3. preparation method according to claim 1, it is characterised in that step（1）Described nano-bioactive glass dust
The chemical composition of body is with CaO-P2O5-SiO2Based on ternary system, wherein, SiO2Mass percent be 40-80%, P2O5's
Mass percent is 1-20%, and CaO mass percent is 10-40%.
4. preparation method according to claim 1, it is characterised in that step（1）The polycaprolactone is molten in electrostatic spinning
Mass volume ratio in liquid is 0.04-0.12 g/ml.
5. preparation method according to claim 1, it is characterised in that step（1）The collagen is in electrostatic spinning solution
Mass volume ratio be 0.04-0.08 g/ml.
6. preparation method according to claim 1, it is characterised in that step（1）The nano-bioactive glass powder
Mass volume ratio in electrostatic spinning solution is 0.02-0.04 g/ml.
7. preparation method according to claim 1, it is characterised in that step（2）The method of the electrostatic spinning is used
Technological parameter be voltage 14-16kV, spinning speed 5-20 μ L/min, the distance of needle point to receiver is 12-20cm；It is described to connect
It is roller or flat receiver to receive device, and the rotating speed of the roller is 5-15rpm.
8. preparation method according to claim 1, it is characterised in that step（2）Used by the electrospinning device
Syringe needle internal diameter is 0.1-1mm, is flat mouth at needle point.
9. preparation method according to claim 1, it is characterised in that step（2）The temperature of described electrostatic spinning is 30-
40 DEG C, relative humidity 20-80%.
A kind of 10. bioactivity glass composite nano-fiber membrane as made from the preparation method described in claim any one of 1-9.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109125782A (en) * | 2018-07-25 | 2019-01-04 | 华南理工大学 | A kind of porous fibre/inorganic bio Particles dispersed type skin wound dressing and preparation method thereof |
| CN110327486A (en) * | 2019-07-02 | 2019-10-15 | 华南理工大学 | A kind of bioactivity glass composite multi-layer nano fiber scaffold and preparation method thereof |
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| JP2006123360A (en) * | 2004-10-29 | 2006-05-18 | Oji Paper Co Ltd | Laminate and its manufacturing method |
| CN102167843A (en) * | 2011-01-28 | 2011-08-31 | 华南理工大学 | Method for preparing collagen modified polycaprolactone/bioactive glass composite material |
| CN104562438A (en) * | 2013-10-17 | 2015-04-29 | 中国科学院理化技术研究所 | Gelatin-based micro-nano fiber membrane material and preparation method and application thereof |
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| JP2006123360A (en) * | 2004-10-29 | 2006-05-18 | Oji Paper Co Ltd | Laminate and its manufacturing method |
| CN102167843A (en) * | 2011-01-28 | 2011-08-31 | 华南理工大学 | Method for preparing collagen modified polycaprolactone/bioactive glass composite material |
| CN104562438A (en) * | 2013-10-17 | 2015-04-29 | 中国科学院理化技术研究所 | Gelatin-based micro-nano fiber membrane material and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125782A (en) * | 2018-07-25 | 2019-01-04 | 华南理工大学 | A kind of porous fibre/inorganic bio Particles dispersed type skin wound dressing and preparation method thereof |
| CN110327486A (en) * | 2019-07-02 | 2019-10-15 | 华南理工大学 | A kind of bioactivity glass composite multi-layer nano fiber scaffold and preparation method thereof |
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